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  1. Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a ...

    Authors: Michael J. McGeachie, Joanne E. Sordillo, Amber Dahlin, Alberta L. Wang, Sharon M. Lutz, Kelan G. Tantisira, Ronald Panganiban, Quan Lu, Satria Sajuthi, Cydney Urbanek, Rachel Kelly, Benjamin Saef, Celeste Eng, Sam S. Oh, Alvin T. Kho, Damien C. Croteau-Chonka…

    Citation: Respiratory Research 2020 21:31

    Content type: Research

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  2. Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molec...

    Authors: Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2020 21:30

    Content type: Research

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  3. Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction be...

    Authors: K. Kahnert, M. Föhrenbach, T. Lucke, P. Alter, F. T. Trudzinski, R. Bals, J. I. Lutter, H. Timmermann, S. Söhler, S. Förderreuther, D. Nowak, H. Watz, B. Waschki, J. Behr, T. Welte, C. F. Vogelmeier…

    Citation: Respiratory Research 2020 21:28

    Content type: Research

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  4. Reduced physical capacity (PC) and physical activity (PA) are common in COPD patients and associated with poor outcome. However, they represent different aspects of physical functioning and interventions do no...

    Authors: Noriane A. Sievi, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jörg D. Leuppi, Robert Thurnheer, Malcolm Kohler and Christian F. Clarenbach

    Citation: Respiratory Research 2020 21:27

    Content type: Research

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    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:112

  5. Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resti...

    Authors: Miguel J. Divo, Michael R. DePietro, John R. Horton, Cherie A. Maguire and Bartolome R. Celli

    Citation: Respiratory Research 2020 21:26

    Content type: Research

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  6. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy cells are well known and dru...

    Authors: Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser and Manuela Funke-Chambour

    Citation: Respiratory Research 2020 21:25

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2020 21:29

  7. Acute respiratory distress syndrome (ARDS), a complex response to various insults, has a high mortality rate. As pulmonary edema resulting from increased vascular permeability is a hallmark of ARDS, management...

    Authors: Yanfei Shen, Guolong Cai, Shangzhong Chen, Caibao Hu and Jing Yan

    Citation: Respiratory Research 2020 21:24

    Content type: Research

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  8. The aim of this study is investigating the benefits and harms of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS).

    Authors: Zhongjun Zheng, Libing Jiang, Song Zhang, Christophe Guervilly, Mao Zhang, Xia Feng and Jianbo Ding

    Citation: Respiratory Research 2020 21:23

    Content type: Research

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  9. Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of c...

    Authors: Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie and Xiao-feng Yan

    Citation: Respiratory Research 2020 21:22

    Content type: Research

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  10. For still unclear reasons, chronic airway infection often occurs in patients with Chronic Obstructive Pulmonary Disease (COPD), particularly in those with more severe airflow limitation. Fatty-acid binding pro...

    Authors: Lídia Perea, Ana Rodrigo-Troyano, Elisabet Cantó, Marisol Domínguez-Álvarez, Jordi Giner, Ferran Sanchez-Reus, Judit Villar-García, Sara Quero, Marian García-Núñez, Alicia Marín, Eduard Monsó, Rosa Faner, Alvar Agustí, Silvia Vidal and Oriol Sibila

    Citation: Respiratory Research 2020 21:21

    Content type: Research

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  11. The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of thi...

    Authors: Ryoung-Eun Ko, Jin Gu Lee, Song Yee Kim, Young Tae Kim, Sun Mi Choi, Do Hyung Kim, Woo Hyun Cho, Seung-Il Park, Kyung-Wook Jo, Hong Kwan Kim, Hyo Chae Paik and Kyeongman Jeon

    Citation: Respiratory Research 2020 21:20

    Content type: Research

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  12. Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment ...

    Authors: Christian Vogelberg, Stanley Goldstein, LeRoy Graham, Alan Kaplan, Alberto de la Hoz and Eckard Hamelmann

    Citation: Respiratory Research 2020 21:19

    Content type: Research

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  13. Recurrent bronchiectasis exacerbations are related to deterioration of lung function, progression of the disease, impairment of quality of life, and to an increased mortality. Improved detection of exacerbatio...

    Authors: Amaia Artaraz, Megan L. Crichton, Simon Finch, Hani Abo-Leyah, Pieter Goeminne, Stefano Aliberti, Thomas Fardon and James D. Chalmers

    Citation: Respiratory Research 2020 21:18

    Content type: Research

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  14. Clinically Important Deterioration (CID) is a novel composite measure to assess treatment effect in chronic obstructive pulmonary disease (COPD). We examined the performance and utility of CID in assessing the...

    Authors: Mona Bafadhel, Dave Singh, Christine Jenkins, Stefan Peterson, Thomas Bengtsson, Peter Wessman and Malin Fagerås

    Citation: Respiratory Research 2020 21:17

    Content type: Research

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  15. Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains ...

    Authors: Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma and Yan Zhao

    Citation: Respiratory Research 2020 21:16

    Content type: Research

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  16. Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiati...

    Authors: Gabriella H. Long, Thomas Southworth, Umme Kolsum, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Citation: Respiratory Research 2020 21:15

    Content type: Letter to the Editor

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  17. Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is li...

    Authors: Yifang Liao, Ping Li, Yanxia Wang, Hong Chen, Shangwei Ning and Dongju Su

    Citation: Respiratory Research 2020 21:14

    Content type: Research

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  18. This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC...

    Authors: Sumin Shin, Yong Soo Choi, Jae Jun Jung, Yunjoo Im, Sun Hye Shin, Danbee Kang, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Keunchil Park, Myung-Ju Ahn, Yong Chan Ahn, Genehee Lee, Juhee Cho…

    Citation: Respiratory Research 2020 21:13

    Content type: Research

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  19. Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen. Prognostication in cHP remains challenging, and the relationsh...

    Authors: Julia Wälscher, Benjamin Gross, Julie Morisset, Kerri A. Johannson, Martina Vasakova, Jacques Bruhwyler and Michael Kreuter

    Citation: Respiratory Research 2020 21:12

    Content type: Research

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  20. Several registries of idiopathic pulmonary fibrosis (IPF) have been established to better understand its natural history, though their size and duration of follow-up are limited. Here, we describe the large Eu...

    Authors: Tanja Tran, Martina Šterclová, Nesrin Mogulkoc, Katarzyna Lewandowska, Veronika Müller, Marta Hájková, Mordechai R. Kramer, Dragana Jovanović, Jasna Tekavec-Trkanjec, Michael Studnicka, Natalia Stoeva, Karel Hejduk, Ladislav Dušek, Samy Suissa and Martina Vašáková

    Citation: Respiratory Research 2020 21:11

    Content type: Research

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  21. Although cavities are an important finding in Mycobacterium avium complex pulmonary disease (MAC-PD), there is little information regarding the types of cavities that indicate disease progression. This study was ...

    Authors: Yohei Oshitani, Seigo Kitada, Ryuya Edahiro, Kazuyuki Tsujino, Hiroyuki Kagawa, Kenji Yoshimura, Keisuke Miki, Mari Miki and Hiroshi Kida

    Citation: Respiratory Research 2020 21:10

    Content type: Research

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  22. High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mecha...

    Authors: Cuiping Fu, Shengyu Hao, Zilong Liu, Liang Xie, Xu Wu, Xiaodan Wu and Shanqun Li

    Citation: Respiratory Research 2020 21:9

    Content type: Research

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  23. While porcine seems to be superior to bovine surfactants in terms of respiratory outcomes, it is unclear if a surfactant can improve extra-pulmonary outcomes in preterm neonates with respiratory distress syndr...

    Authors: Silvia Foligno and Daniele De Luca

    Citation: Respiratory Research 2020 21:8

    Content type: Research

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  24. The approvals of nintedanib and pirfenidone changed the treatment paradigm in idiopathic pulmonary fibrosis (IPF), and increased our understanding of the underlying disease mechanisms. Nonetheless, many challe...

    Authors: Claudia Valenzuela, Sebastiano Emanuele Torrisi, Nicolas Kahn, Manuel Quaresma, Susanne Stowasser and Michael Kreuter

    Citation: Respiratory Research 2020 21:7

    Content type: Review

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  25. Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase,...

    Authors: David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli and Paola Rottoli

    Citation: Respiratory Research 2020 21:6

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2020 21:34

  26. Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or the use of asthma medication for ALRTI in patients wit...

    Authors: Rachel Denholm, Esther T. van der Werf and Alastair D. Hay

    Citation: Respiratory Research 2020 21:4

    Content type: Research

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  27. Blood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescrib...

    Authors: Timothy H. Harries, Victoria Rowland, Christopher J. Corrigan, Iain J. Marshall, Lucy McDonnell, Vibhore Prasad, Peter Schofield, David Armstrong and Patrick White

    Citation: Respiratory Research 2020 21:3

    Content type: Research

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  28. Idiopathic pulmonary fibrosis (IPF) is a fatal disease that results in poor quality of life due to progressive respiratory symptoms, anxiety, and depression. Palliative care improves quality of life and surviv...

    Authors: Katherine Janssen, Drew Rosielle, Qi Wang and Hyun Joo Kim

    Citation: Respiratory Research 2020 21:2

    Content type: Research

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  29. To observe the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for pulmonary alveolar proteinosis (PAP).

    Authors: Fen Zhang, Dong Weng, Yiliang Su, Chengsheng Yin, Li Shen, Yuan Zhang, Ying Zhou, Qiuhong Li, Yang Hu and Huiping Li

    Citation: Respiratory Research 2020 21:1

    Content type: Research

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  30. Ventilator-induced diaphragmatic dysfunction is a serious complication associated with higher ICU mortality, prolonged mechanical ventilation, and unsuccessful withdrawal from mechanical ventilation. Although ...

    Authors: Tatsutoshi Shimatani, Nobuaki Shime, Tomohiko Nakamura, Shinichiro Ohshimo, Justin Hotz and Robinder G. Khemani

    Citation: Respiratory Research 2019 20:293

    Content type: Research

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  31. In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell type...

    Authors: Irina Wojahn, Timo H. Lüdtke, Vincent M. Christoffels, Mark-Oliver Trowe and Andreas Kispert

    Citation: Respiratory Research 2019 20:292

    Content type: Research

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  32. Low-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, data on the socioeconomic impact of respiratory dise...

    Authors: Evelyn A. Brakema, Aizhamal Tabyshova, Rianne M. J. J. van der Kleij, Talant Sooronbaev, Christos Lionis, Marilena Anastasaki, Pham Le An, Luan Than Nguyen, Bruce Kirenga, Simon Walusimbi, Maarten J. Postma, Niels H. Chavannes and Job F. M. van Boven

    Citation: Respiratory Research 2019 20:291

    Content type: Research

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  33. Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated...

    Authors: Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard and B. S. Pollard

    Citation: Respiratory Research 2019 20:290

    Content type: Research

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  34. Increased numbers of blood and sputum eosinophils are associated with higher exacerbation frequency and increased asthma severity. In clinical trials, targeting Interleukin-5 has been shown to be a useful ther...

    Authors: H. Ibrahim, R. O’Sullivan, D. Casey, J. Murphy, J. MacSharry, B. J. Plant and D. M. Murphy

    Citation: Respiratory Research 2019 20:289

    Content type: Letter to the Editor

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  35. Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection during childhood may polarise the immune system towards...

    Authors: Brian R. Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson, Barbara Young and Brian O’Connor

    Citation: Respiratory Research 2019 20:288

    Content type: Research

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  36. Acute exacerbation of chronic fibrosing idiopathic interstitial pneumonias (AE-IIPs) is associated with a high mortality rate. In 2016, an international working group proposed a revised diagnostic criteria for...

    Authors: Motoyasu Kato, Tomoko Yamada, Shunichi Kataoka, Yuta Arai, Keita Miura, Yusuke Ochi, Hiroaki Ihara, Ryo Koyama, Shinichi Sasaki and Kazuhisa Takahashi

    Citation: Respiratory Research 2019 20:287

    Content type: Research

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  37. Macrolide is a key drug in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Macrolide-resistant MAC is gaining importance, but there are little data in clinical characteristics and treatme...

    Authors: Youngmok Park, Eun Hye Lee, Inkyung Jung, Goeun Park and Young Ae Kang

    Citation: Respiratory Research 2019 20:286

    Content type: Research

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  38. β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (....

    Authors: Yi-fei Chen, Ge Huang, Yi-min Wang, Ming Cheng, Fang-fang Zhu, Jin-nan Zhong and Ya-dong Gao

    Citation: Respiratory Research 2019 20:285

    Content type: Research

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  39. Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated ...

    Authors: Deirdre F. Gilpin, Katie-Ann McGown, Kevin Gallagher, Jose Bengoechea, Amy Dumigan, Gisli Einarsson, J. Stuart Elborn and Michael M. Tunney

    Citation: Respiratory Research 2019 20:267

    Content type: Research

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  40. Recent advances in the functional analyses of endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs), have provided a new perspective on the crucial roles of RNA in gene regulati...

    Authors: Parameet Kumar, Chaitali Sen, Kathryn Peters, Raymond A. Frizzell and Roopa Biswas

    Citation: Respiratory Research 2019 20:284

    Content type: Research

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  41. There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of...

    Authors: Jin Hwa Song, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung and Jung-Kyu Lee

    Citation: Respiratory Research 2019 20:283

    Content type: Research

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  42. Airway mucus hypersecretion is an important pathophysiological feature in asthma. Mucins are glycoproteins that are mainly responsible for the viscoelastic property of mucus, and MUC5AC is a major mucin glycop...

    Authors: Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Juan Liu, Rong-Fei Sun, Xue-Jiao Qian and Jiang-Bo Liu

    Citation: Respiratory Research 2019 20:282

    Content type: Research

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  43. Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has bee...

    Authors: Wei Liu, Jeffrey A. Meridew, Aja Aravamudhan, Giovanni Ligresti, Daniel J. Tschumperlin and Qi Tan

    Citation: Respiratory Research 2019 20:281

    Content type: Research

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  44. There is currently no method that can predict whether or under what condition hypopnea, even obstructive sleep apnea (OSA), will occur during sleep for individuals based on credible parameters measured under w...

    Authors: Hongyi Lin, Cunting Wang, Han Zhang, Huahui Xiong, Zheng Li, Xiaoqing Huang, Changjin Ji, Junfang Xian and Yaqi Huang

    Citation: Respiratory Research 2019 20:280

    Content type: Research

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  45. Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical paramet...

    Authors: Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee and Ji Ye Jung

    Citation: Respiratory Research 2019 20:279

    Content type: Research

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  46. Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). T...

    Authors: Léo Blervaque, Emilie Passerieux, Pascal Pomiès, Matthias Catteau, Nelly Héraud, Marine Blaquière, François Bughin, Bronia Ayoub, Nicolas Molinari, Jean-Paul Cristol, Antonia Perez-Martin, Jacques Mercier, Maurice Hayot and Fares Gouzi

    Citation: Respiratory Research 2019 20:278

    Content type: Research

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  47. Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and no...

    Authors: Hannah R. Whittaker, Debbie Jarvis, Mohamed R. Sheikh, Steven J. Kiddle and Jennifer K. Quint

    Citation: Respiratory Research 2019 20:277

    Content type: Review

    Published on:

  48. Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scal...

    Authors: Xinyi Li, Hengye Huang, Huajun Xu, Yue Shi, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan and Shankai Yin

    Citation: Respiratory Research 2019 20:276

    Content type: Research

    Published on:

  49. Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasi...

    Authors: Hélène Goussault, Hélène Salvator, Emilie Catherinot, Marie-Laure Chabi, Colas Tcherakian, Alexandre Chabrol, Morgane Didier, Elisabeth Rivaud, Alain Fischer, Felipe Suarez, Olivier Hermine, Fanny Lanternier, Olivier Lortholary, Nizar Mahlaoui, Philippe Devillier and Louis-Jean Couderc

    Citation: Respiratory Research 2019 20:275

    Content type: Research

    Published on:

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