Skip to main content

Articles

Page 6 of 67

  1. Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.

    Authors: Ryota Dokuni, Tatsuya Nagano, Naoe Jimbo, Hiroki Sato, Tatsunori Kiriu, Yuichiro Yasuda, Masatsugu Yamamoto, Motoko Tachihara, Kazuyuki Kobayashi, Yoshimasa Maniwa and Yoshihiro Nishimura

    Citation: Respiratory Research 2020 21:331

    Content type: Research

    Published on:

  2. Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway infl...

    Authors: Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht and Annelie F. Behndig

    Citation: Respiratory Research 2020 21:330

    Content type: Research

    Published on:

  3. Acute lung injury (ALI) is a clinical syndrome with high morbidity and mortality, and severe pulmonary edema is one of the characteristics. Epithelial sodium channel (ENaC) located on the apical side of alveol...

    Authors: Honglei Zhang, Yan Ding, Yapeng Hou, Yanhong Liu, Zhiyu Zhou and Hongguang Nie

    Citation: Respiratory Research 2020 21:329

    Content type: Research

    Published on:

  4. Since the coronavirus disease 2019 (COVID-19) identified in Wuhan, Hubei, China in December 2019, it has been characterized as a pandemic by World Health Organization (WHO). It was reported that asymptomatic p...

    Authors: Chaojie Wei, Yufeng Yuan and Zhenshun Cheng

    Citation: Respiratory Research 2020 21:327

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:21

  5. Pulmonary infections are associated with a brisk inflammatory reaction to bacterial surface components. Lipopolysaccharides (LPS) trigger macrophage activation and release of mitochondrial metabolites that con...

    Authors: Sebastián A. Riquelme and Alice Prince

    Citation: Respiratory Research 2020 21:326

    Content type: Review

    Published on:

  6. Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of th...

    Authors: Longxiang Su, Zhongheng Zhang, Fanglan Zheng, Pan Pan, Na Hong, Chun Liu, Jie He, Weiguo Zhu, Yun Long and Dawei Liu

    Citation: Respiratory Research 2020 21:325

    Content type: Research

    Published on:

  7. Noninvasive ventilation (NIV) represents an effective treatment for chronic respiratory failure. However, empirically determined NIV settings may not achieve optimal ventilatory support. Therefore, the efficac...

    Authors: Marjolaine Georges, Claudio Rabec, Elise Monin, Serge Aho, Guillaume Beltramo, Jean-Paul Janssens and Philippe Bonniaud

    Citation: Respiratory Research 2020 21:324

    Content type: Research

    Published on:

  8. The effects of triple therapy on gas trapping in COPD are not fully understood. We evaluated the effects of the long acting bronchodilator components of the extrafine single inhaler triple therapy beclometason...

    Authors: James Dean, Catalina Panainte, Naimat Khan and Dave Singh

    Citation: Respiratory Research 2020 21:323

    Content type: Research

    Published on:

  9. Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbiditi...

    Authors: Alyson W. Wong, Tae Yoon Lee, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Charlene D. Fell, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Gerard Cox, Andrew J. Halayko, Nathan Hambly, Helene Manganas, Mohsen Sadatsafavi, Pearce G. Wilcox, Teresa To…

    Citation: Respiratory Research 2020 21:322

    Content type: Research

    Published on:

  10. Despite the availability of multi-“omics” strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity o...

    Authors: Nancy G. Casanova, Manuel L. Gonzalez-Garay, Belinda Sun, Christian Bime, Xiaoguang Sun, Kenneth S. Knox, Elliott D. Crouser, Nora Sammani, Taylor Gonzales, Bhupinder Natt, Sachin Chaudhary, Yves Lussier and Joe G. N. Garcia

    Citation: Respiratory Research 2020 21:321

    Content type: Research

    Published on:

  11. The disposable bronchoscope is an excellent alternative to face the problem of SARS-CoV-2 and other cross infections, but the bronchoscopist's perception of its quality has not been evaluated.

    Authors: Javier Flandes, Luis Fernando Giraldo-Cadavid, Javier Alfayate, Iker Fernández-Navamuel, Carlos Agusti, Carmen M. Lucena, Antoni Rosell, Felipe Andreo, Carmen Centeno, Carmen Montero, Iria Vidal, Lucía García-Alfonso, Antonio Bango, Miguel Ariza, Rocío Gallego, Marta Orta…

    Citation: Respiratory Research 2020 21:320

    Content type: Research

    Published on:

  12. Exacerbation of chronic obstructive pulmonary disease (COPD) severely impacts the quality of life and causes high mortality and morbidity. COPD is involved with systemic and pulmonary inflammation, which may b...

    Authors: Meng-Ting Wang, Jyun-Heng Lai, Ya-Ling Huang, Feng-Chih Kuo, Yun-Han Wang, Chen-Liang Tsai and Min-Yu Tu

    Citation: Respiratory Research 2020 21:319

    Content type: Research

    Published on:

  13. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the group of Betacoronaviruses. The SARS-CoV-2 is closely related to SARS-CoV-1 and probably originated either from bats or pangolins. SA...

    Authors: Meghana Rastogi, Neha Pandey, Astha Shukla and Sunit K. Singh

    Citation: Respiratory Research 2020 21:318

    Content type: Review

    Published on:

  14. Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airwa...

    Authors: Shengjie Xu, Anthony Schwab, Nikhil Karmacharya, Gaoyuan Cao, Joanna Woo, Nicholas Kim, Steven S. An, Reynold A. Panettieri Jr and Joseph A. Jude

    Citation: Respiratory Research 2020 21:317

    Content type: Research

    Published on:

  15. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. ...

    Authors: Kimiyuki Ikeda, Hirofumi Chiba, Hirotaka Nishikiori, Arata Azuma, Yasuhiro Kondoh, Takashi Ogura, Yoshio Taguchi, Masahito Ebina, Hiroki Sakaguchi, Shogo Miyazawa, Moritaka Suga, Yukihiko Sugiyama, Toshihiro Nukiwa, Shoji Kudoh and Hiroki Takahashi

    Citation: Respiratory Research 2020 21:316

    Content type: Research

    Published on:

  16. We would like to comment on the article entitled “Association between cytokine profiles and lung injury in COVID-19 pneumonia” by Li-Da Chen and colleagues, with respect to emerging data regarding the immunopa...

    Authors: Jaya Ponnampalam, George Seligmann, Tanaya Gandhi and Dilen Parmar

    Citation: Respiratory Research 2020 21:315

    Content type: Letter to the Editor

    Published on:

    The original article was published in Respiratory Research 2020 21:201

  17. Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed...

    Authors: Siqin Zhang, Lin Liu, Bin Yang, Rou Li, Jianhua Luo, Jing Huang, Yanjun Long, Ying Huang, Jianping Zhou, Yan Zha and Xiangyan Zhang

    Citation: Respiratory Research 2020 21:314

    Content type: Research

    Published on:

  18. The clinical characteristics and outcomes of the 2019 novel coronavirus (COVID-19) pneumonia are different in Hubei compared to other regions in China. But there are few comparative studies on the differences ...

    Authors: Chang Wang, Lizhi Zhou, Juan Chen, Yong Yang, Tianlong Huang, Min Fu, Ya Li, Daniel M. George and Xiangyu Chen

    Citation: Respiratory Research 2020 21:313

    Content type: Research

    Published on:

  19. Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are ass...

    Authors: Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma and Vincent Cottin

    Citation: Respiratory Research 2020 21:312

    Content type: Research

    Published on:

  20. Sexual function is often affected in patients suffering from chronic diseases especially chronic obstructive pulmonary disease (COPD). However, the effect of COPD on sexual satisfaction is underappreciated in ...

    Authors: M. Zysman, J. Rubenstein, F. Le Guillou, R. M. H. Colson, C. Pochulu, L. Grassion, R. Escamilla, D. Piperno, J. Pon, S. Khan and C. Raherison-Semjen

    Citation: Respiratory Research 2020 21:311

    Content type: Research

    Published on:

  21. Only few randomized controlled trials (RCTs) for head-to-head comparison have been conducted between various combinations of long-acting muscarinic antagonists (LAMAs) and long-acting beta-agonists (LABAs). Ou...

    Authors: Hyun Woo Lee, Jimyung Park, Eun Jin Jang and Chang-Hoon Lee

    Citation: Respiratory Research 2020 21:310

    Content type: Research

    Published on:

  22. Coronavirus disease COVID-19 has become a public health emergency of international concern. Together with the quest for an effective treatment, the question of the post-infectious evolution of affected patient...

    Authors: AN Frix, L. Schoneveld, A. Ladang, M. Henket, B. Duysinx, F. Vaillant, B. Misset, M. Moutschen, R. Louis, E. Cavalier and J. Guiot

    Citation: Respiratory Research 2020 21:309

    Content type: Letter to the Editor

    Published on:

  23. Despite demonstrated symptomatic benefit from bronchial thermoplasty (BT), the underlying pathophysiological benefits have been uncertain. The purpose of the present study was to relate clinical benefit after ...

    Authors: David Langton, Kim Bennetts, Francis Thien, Virginia Plummer and Peter B. Noble

    Citation: Respiratory Research 2020 21:308

    Content type: Research

    Published on:

  24. The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS...

    Authors: Fengyun Wang, Bin Fang, Xinhua Qiang, Jingsong Shao and Lixin Zhou

    Citation: Respiratory Research 2020 21:307

    Content type: Research

    Published on:

  25. Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete or partial obstruction of the upper airways during sleep. Conscious sedation for flexible bronchoscopy (FB) places patients in ...

    Authors: Andrei M. Darie, Desiree M. Schumann, Marco Laures, Werner Strobel, Kathleen Jahn, Eric Pflimlin, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2020 21:306

    Content type: Research

    Published on:

  26. Exposure to electronic-cigarette (e-cig) aerosols induces potentially fatal e-cig or vaping-associated lung injury (EVALI). The cellular and molecular mechanisms underlying these effects, however, are unknown....

    Authors: Alexandra Noël, Ekhtear Hossain, Zakia Perveen, Hasan Zaman and Arthur L. Penn

    Citation: Respiratory Research 2020 21:305

    Content type: Research

    Published on:

  27. Multiple classes of oral therapy are available for the treatment of pulmonary arterial hypertension (PAH), but there is little to guide clinicians in choosing a specific regimen or therapeutic class. We aimed ...

    Authors: Aparna C. Swaminathan, Hongmei Zhu, Victor Tapson, Yuliya Lokhnygina, Abby Poms, Zach Kelleher, Elijah Gaspard, Karla Kennedy, Brian E. Fee, Terry Fortin, S. Nicholas Mason, Kishan Parikh and Tim J. McMahon

    Citation: Respiratory Research 2020 21:304

    Content type: Research

    Published on:

  28. Pulmonary hypertension (PH) developing secondarily in pulmonary fibrosis (PF) patients (PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very concerning since the presence of PH i...

    Authors: Grégoire Ruffenach, Jason Hong, Mylène Vaillancourt, Lejla Medzikovic and Mansoureh Eghbali

    Citation: Respiratory Research 2020 21:303

    Content type: Review

    Published on:

  29. Characterized by abnormal lung growth or maturation, congenital diaphragmatic hernia (CDH) affects 1:3000 live births. Cellular studies report proximal (SOX2+) and distal (SOX9+) progenitor cells as key modulator...

    Authors: Ana N. Gonçalves, Jorge Correia-Pinto and Cristina Nogueira-Silva

    Citation: Respiratory Research 2020 21:302

    Content type: Research

    Published on:

  30. Tidal expiratory flow limitation (EFLT) promotes intrinsic PEEP (PEEPi) in patients with chronic obstructive pulmonary disease (COPD). Applying non-invasive ventilation (NIV) with an expiratory positive airway pr...

    Authors: Emanuela Zannin, Ilaria Milesi, Roberto Porta, Simona Cacciatore, Luca Barbano, R. Trentin, Francesco Fanfulla, Michele Vitacca and Raffaele L. Dellacà

    Citation: Respiratory Research 2020 21:301

    Content type: Research

    Published on:

  31. Globally, a surge in electronic cigarette (e-cigarette) use has been observed in recent years, with youth being the most susceptible group. Given their recent emergence, studies assessing the health consequenc...

    Authors: Abdullah Alnajem, Abdullah Redha, Dalal Alroumi, Ahmed Alshammasi, Mohamad Ali, Maram Alhussaini, Waad Almutairi, Ali Esmaeil and Ali H. Ziyab

    Citation: Respiratory Research 2020 21:300

    Content type: Research

    Published on:

  32. Epidemiological studies have found strong associations between air pollution and respiratory effects including development and/or exacerbation of asthma and chronic obstructive pulmonary disease (COPD) as well...

    Authors: Marit Låg, Johan Øvrevik, Magne Refsnes and Jørn A. Holme

    Citation: Respiratory Research 2020 21:299

    Content type: Review

    Published on:

  33. Calcium is an important coagulation factor and hypocalcemia is related to progression and poor prognosis of many cardiopulmonary diseases. However, influence of hypocalcemia on pulmonary thromboembolism (PTE) ...

    Authors: Xin Wang, Yongbo Xiang, Ting Zhang, Yuqing Yang, Xuefeng Sun and Juhong Shi

    Citation: Respiratory Research 2020 21:298

    Content type: Research

    Published on:

  34. As it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the characteristics of the pain in the patients with ILD.

    Authors: Qinxue Shen, Ting Guo, Min Song, Wei Guo, Yi Zhang, Wang Duan, Yating Peng, Shanshan Ni, Xiaoli Ouyang and Hong Peng

    Citation: Respiratory Research 2020 21:297

    Content type: Research

    Published on:

  35. Patient–ventilator asynchrony is associated with increased morbidity and mortality. A direct causative relationship between Patient–ventilator asynchrony and adverse clinical outcome have yet to be demonstrate...

    Authors: Robert G. T. Blokpoel, Alette A. Koopman, Jefta van Dijk and Martin C. J. Kneyber

    Citation: Respiratory Research 2020 21:296

    Content type: Research

    Published on:

  36. A new clinical guideline for idiopathic pulmonary fibrosis (IPF) uses high-resolution computed tomography (HRCT) patterns for diagnostic purposes. However, it is unknown how they relate to the IPF clinical cou...

    Authors: Byoung Soo Kwon, Jooae Choe, Kyung Hyun Do, Hee Sang Hwang, Eun Jin Chae and Jin Woo Song

    Citation: Respiratory Research 2020 21:295

    Content type: Research

    Published on:

  37. Septic-acute respiratory distress syndrome (ARDS), characterized by the acute lung injury (ALI) secondary to aberrant systemic inflammatory response, has high morbidity and mortality. Despite increased underst...

    Authors: Liu Yang, Sijie Liu, Silu Han, Yuhan Hu, Zhipeng Wu, Xiaoqian Shi, Baosen Pang, Yingmin Ma and Jiawei Jin

    Citation: Respiratory Research 2020 21:293

    Content type: Research

    Published on:

  38. There is increasing evidence that the lung is a target organ of diabetes. This study aimed to examine in detail the association between diabetes mellitus and pulmonary function using a national cohort. We also...

    Authors: Rui-Heng Zhang, Jian-Bo Zhou, Yao-Hua Cai, Lin-Ping Shu, Rafael Simó and Albert Lecube

    Citation: Respiratory Research 2020 21:292

    Content type: Research

    Published on:

  39. Body mass index (BMI) is an important parameter associated with mortality and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD). However, informed guidance on stratified we...

    Authors: Manuel B. Huber, Christoph Kurz, Florian Kirsch, Larissa Schwarzkopf, Anja Schramm and Reiner Leidl

    Citation: Respiratory Research 2020 21:291

    Content type: Research

    Published on:

  40. The poor understanding of pathogenesis in idiopathic pulmonary fibrosis (IPF) impaired development of effective therapeutic strategies. The aim of the current study is to investigate the roles of long non-codi...

    Authors: Xiaoyu Wan, Xinbei Tian, Jun Du, Ying Lu and Yongtao Xiao

    Citation: Respiratory Research 2020 21:290

    Content type: Research

    Published on:

  41. There is evidence that bacterial colonisation in chronic obstructive pulmonary disease (COPD) is associated with increased neutrophilic airway inflammation. This study tested the hypothesis that different bact...

    Authors: Augusta S. Beech, Simon Lea, Umme Kolsum, Zhang Wang, Bruce E. Miller, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Citation: Respiratory Research 2020 21:289

    Content type: Research

    Published on:

  42. Benefits of variable mechanical ventilation based on the physiological breathing pattern have been observed both in healthy and injured lungs. These benefits have not been characterized in pediatric models and...

    Authors: Andre Dos Santos Rocha, Gergely H. Fodor, Miklos Kassai, Loic Degrugilliers, Sam Bayat, Ferenc Petak and Walid Habre

    Citation: Respiratory Research 2020 21:288

    Content type: Research

    Published on:

  43. Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expresse...

    Authors: Huan Liu, Qian Cheng, Dong-sheng Xu, Wen Wang, Zheng Fang, Dong-dong Xue, Ya Zheng, Alex H. Chang and Yan-jun Lei

    Citation: Respiratory Research 2020 21:287

    Content type: Research

    Published on:

  44. It has been recently hypothesized that infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to fibrotic sequelae in patients recovering from coronavirus disease 2019 (COVID-19). I...

    Authors: Paola Rogliani, Luigino Calzetta, Angelo Coppola, Ermanno Puxeddu, Gianluigi Sergiacomi, Dejanira D’Amato and Antonio Orlacchio

    Citation: Respiratory Research 2020 21:286

    Content type: Letter to the Editor

    Published on:

  45. A number of single-inhaler triple therapies are being developed for asthma, including the extrafine formulation of beclometasone dipropionate (BDP), formoterol fumarate (FF), and glycopyrronium (G). Given asth...

    Authors: Dave Singh, Johann Christian Virchow, Giorgio Walter Canonica, Andrea Vele, Maxim Kots, George Georges and Alberto Papi

    Citation: Respiratory Research 2020 21:285

    Content type: Research

    Published on:

  46. Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off...

    Authors: Hai Zhang, Changhui Li, Fang Hu, Xueyan Zhang, Yinchen Shen, Yuqing Chen and Feng Li

    Citation: Respiratory Research 2020 21:284

    Content type: Research

    Published on:

  47. COPD has increased in prevalence worldwide over several decades until the first decade after the millennium shift. Evidence from a few recent population studies indicate that the prevalence may be levelling or...

    Authors: Helena Backman, Lowie Vanfleteren, Anne Lindberg, Linda Ekerljung, Caroline Stridsman, Malin Axelsson, Ulf Nilsson, Bright I. Nwaru, Sami Sawalha, Berne Eriksson, Linnea Hedman, Madeleine Rådinger, Sven-Arne Jansson, Anders Ullman, Hannu Kankaanranta, Jan Lötvall…

    Citation: Respiratory Research 2020 21:283

    Content type: Research

    Published on:

  48. Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are removed from the respiratory tract are indispensabl...

    Authors: Yosuke Kamiya, Tomoyuki Fujisawa, Mineo Katsumata, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Mitsutoshi Setou, Masahiko Ito, Tetsuro Suzuki, Koji Ikegami and Takafumi Suda

    Citation: Respiratory Research 2020 21:282

    Content type: Research

    Published on:

  49. Thoracentesis is a low-risk procedure for bleeding (approx. 2%). Data regarding safety of thoracentesis under treatment with clopidogrel is scarce, and current guidelines are not evidence based. We performed a...

    Authors: Sivan Perl, Marina Bondarenco, Noam Natif, Yitschak Shpirer, Sharon Enghelberg and Benjamin Fox

    Citation: Respiratory Research 2020 21:281

    Content type: Research

    Published on:

Annual Journal Metrics