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  1. Research

    Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease

    It has been observed that mice lacking the sulfatase modifying factor (Sumf1) developed an emphysema-like phenotype. However, it is unknown if SUMF1 may play a role in Chronic Obstructive Pulmonary Disease (COPD)...

    Julie Weidner, Linnea Jarenbäck, Kim de Jong, Judith M. Vonk, Maarten van den Berge, Corry-Anke Brandsma, H. Marike Boezen, Don Sin, Yohan Bossé, David Nickle, Jaro Ankerst, Leif Bjermer, Dirkje S. Postma, Alen Faiz and Ellen Tufvesson

    Respiratory Research 2017 18:77

    Published on: 2 May 2017

  2. Research

    Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study

    Although high-intensity non-invasive ventilation has been shown to improve outcomes in stable COPD, it may adversely affect cardiac performance. Therefore, the aims of the present pilot study were to compare c...

    Marieke Leontine Duiverman, Petra Maagh, Friederike Sophie Magnet, Claudia Schmoor, Maria Paola Arellano-Maric, Axel Meissner, Jan Hendrik Storre, Peter Jan Wijkstra, Wolfram Windisch and Jens Callegari

    Respiratory Research 2017 18:76

    Published on: 2 May 2017

  3. Research

    Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

    Exacerbations in COPD are often accompanied by pulmonary and systemic inflammation, and associated with increased susceptibility to and prevalence of weight loss and muscle wasting. Muscle mass loss during dis...

    Judith J. M. Ceelen, Annemie M. W. J. Schols, Stefan J. van Hoof, Chiel C. de Theije, Frank Verhaegen and Ramon C. J. Langen

    Respiratory Research 2017 18:75

    Published on: 2 May 2017

  4. Research

    Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts

    Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma....

    Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng and James Chung-Man Ho

    Respiratory Research 2017 18:80

    Published on: 2 May 2017

  5. Research

    Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers

    Identification of biomarkers of cigarette smoke –induced lung damage and early COPD is an area of intense interest. Glucose regulated protein of 78 kD (i.e., GRP78), a multi-functional protein which mediates c...

    Mark O. Aksoy, Victor Kim, William D. Cornwell, Thomas J. Rogers, Beata Kosmider, Karim Bahmed, Carlos Barrero, Salim Merali, Neena Shetty and Steven G. Kelsen

    Respiratory Research 2017 18:78

    Published on: 2 May 2017

  6. Research

    β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells

    Epithelial-mesenchymal transition is currently recognized as an important mechanism for the increased number of myofibroblasts in cancer and fibrotic diseases. We have already reported that epithelial-mesenchy...

    Keigo Kainuma, Tetsu Kobayashi, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Hajime Fujimoto, Yu Kuwabara, Koa Hosoki, Mizuho Nagao, Takao Fujisawa and Esteban C. Gabazza

    Respiratory Research 2017 18:79

    Published on: 2 May 2017

  7. Research

    [18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an unpredictable course. Prognostic markers and disease activity markers are needed. The purpose of this single-center retrospectiv...

    Aurélien Justet, Astrid Laurent-Bellue, Gabriel Thabut, Arnaud Dieudonné, Marie-Pierre Debray, Raphael Borie, Michel Aubier, Rachida Lebtahi and Bruno Crestani

    Respiratory Research 2017 18:74

    Published on: 27 April 2017

  8. Research

    Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease

    Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death and there is a huge unmet clinical need to identify disease biomarkers in peripheral blood. Compared to gene level dif...

    Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré and Don D. Sin

    Respiratory Research 2017 18:72

    Published on: 24 April 2017

  9. Research

    Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

    Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of the inflammatory process. NAMPT inhibition has a beneficial effect in the treatmen...

    Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang and Shi-Jye Chu

    Respiratory Research 2017 18:71

    Published on: 24 April 2017

  10. Research

    Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats

    Rab38 small GTPase regulates intracellular transport in melanocytes and alveolar type II epithelial cells. Ruby rats carrying Rab38 and other gene mutations exhibit oculocutaneous albinism, bleeding diathesis, an...

    Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno and Hirohisa Toga

    Respiratory Research 2017 18:70

    Published on: 24 April 2017

  11. Review

    Understanding the impact of symptoms on the burden of COPD

    Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightne...

    Marc Miravitlles and Anna Ribera

    Respiratory Research 2017 18:67

    Published on: 21 April 2017

  12. Research

    Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: a nationwide retrospective cohort study in Japan

    The effectiveness of early pulmonary rehabilitation (PR) for exacerbation of chronic obstructive pulmonary disease (COPD) remains controversial. The present study aimed to compare the outcomes between early an...

    Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi and Hideo Yasunaga

    Respiratory Research 2017 18:68

    Published on: 21 April 2017

  13. Research

    Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

    Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2...

    Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima…

    Respiratory Research 2017 18:69

    Published on: 21 April 2017

  14. Research

    Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

    Avian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related ...

    Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi and Naohiko Inase

    Respiratory Research 2017 18:65

    Published on: 20 April 2017

  15. Research

    Monitoring mandibular movements to detect Cheyne-Stokes Breathing

    The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (...

    Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E. Silkoff, David Gozal and Jean-Louis Pepin

    Respiratory Research 2017 18:66

    Published on: 20 April 2017

  16. Research

    Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

    Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects and role in lung injury have not been...

    Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap and Bernard Maitre

    Respiratory Research 2017 18:64

    Published on: 19 April 2017

  17. Research

    Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children

    Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μ...

    Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller

    Respiratory Research 2017 18:63

    Published on: 19 April 2017

  18. Research

    Computational modeling of airway instability and collapse in tracheomalacia

    Tracheomalacia (TM) is a condition of excessive tracheal collapse during exhalation. Both acquired and congenital forms of TM are believed to result from morphological changes in cartilaginous, fibrous and/or ...

    Scott J. Hollister, Maximilian P. Hollister and Sebastian K. Hollister

    Respiratory Research 2017 18:62

    Published on: 19 April 2017

  19. Research

    Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

    Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matc...

    Elizabeth Córdoba-Lanús, Sara Cazorla-Rivero, Adriana Espinoza-Jiménez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli and Ciro Casanova

    Respiratory Research 2017 18:59

    Published on: 13 April 2017

    The Erratum to this article has been published in Respiratory Research 2017 18:113

  20. Research

    Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate

    Researchers investigating lung diseases, such as asthma, have questioned whether certain compounds previously reported in exhaled breath condensate (EBC) originate from saliva contamination. Moreover, despite ...

    Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie and Nichole Reisdorph

    Respiratory Research 2017 18:57

    Published on: 12 April 2017

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