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  1. Content type: Research

    Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps ...

    Authors: Katerina D. Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V. Koutsopoulos, Eleni D. Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M. Siafakas, Nikolaos Tzanakis, Athol U. Wells and Katerina M. Antoniou

    Citation: Respiratory Research 2017 18:218

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  2. Content type: Research

    In vitro systems of primary cystic fibrosis (CF) airway epithelial cells are an important tool to study molecular and functional features of the native respiratory epithelium. However, undifferentiated CF airw...

    Authors: Aline Schögler, Fabian Blank, Melanie Brügger, Seraina Beyeler, Stefan A. Tschanz, Nicolas Regamey, Carmen Casaulta, Thomas Geiser and Marco P. Alves

    Citation: Respiratory Research 2017 18:215

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  3. Content type: Research

    Agriculture organic dust exposures induce lung disease with lymphoid aggregates comprised of both T and B cells. The precise role of B cells in mediating lung inflammation is unknown, yet might be relevant giv...

    Authors: Jill A. Poole, Ted R. Mikuls, Michael J. Duryee, Kristi J. Warren, Todd A. Wyatt, Amy J. Nelson, Debra J. Romberger, William W. West and Geoffrey M. Thiele

    Citation: Respiratory Research 2017 18:214

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  4. Content type: Research

    Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflam...

    Authors: Matthew L. Stone, Yunge Zhao, J. Robert Smith, Mark L. Weiss, Irving L. Kron, Victor E. Laubach and Ashish K. Sharma

    Citation: Respiratory Research 2017 18:212

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  5. Content type: Research

    Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigat...

    Authors: Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma…

    Citation: Respiratory Research 2017 18:213

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  6. Content type: Review

    The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data fro...

    Authors: Andrea Gramegna, Francesco Amati, Leonardo Terranova, Giovanni Sotgiu, Paolo Tarsia, Daniela Miglietta, Maria Adelaide Calderazzo, Stefano Aliberti and Francesco Blasi

    Citation: Respiratory Research 2017 18:211

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  7. Content type: Research

    Although the majority of solitary fibrous tumors of the pleura (SFTP) follow a benign course, 10–25% of patients suffer from recurrence or metastatic disease. Several scoring models have been proposed to predi...

    Authors: Matthias Diebold, Alex Soltermann, Selma Hottinger, Sarah R. Haile, Lukas Bubendorf, Paul Komminoth, Wolfram Jochum, Rainer Grobholz, Dirk Theegarten, Sabina Berezowska, Kaid Darwiche, Filiz Oezkan, Malcolm Kohler and Daniel P. Franzen

    Citation: Respiratory Research 2017 18:210

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  8. Content type: Research

    Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with large negative intrathoracic pressures, due to strenuous contractions of the inspiratory muscles. IRB is sho...

    Authors: Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis and Theodoros Vassilakopoulos

    Citation: Respiratory Research 2017 18:209

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  9. Content type: Research

    Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Ye...

    Authors: P.-J. Royer, K. Henrio, M. Pain, J. Loy, A. Roux, A. Tissot, P. Lacoste, C. Pison, S. Brouard and A. Magnan

    Citation: Respiratory Research 2017 18:208

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  10. Content type: Research

    Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammatio...

    Authors: Amandine Vargas, Roxane Boivin, Patricia Cano, Yoana Murcia, Isabelle Bazin and Jean-Pierre Lavoie

    Citation: Respiratory Research 2017 18:207

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  11. Content type: Research

    This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airf...

    Authors: Leif Bjermer, Job F. M. van Boven, Madlaina Costa-Scharplatz, Dorothy L. Keininger, Florian S. Gutzwiller, Karin Lisspers, Ronan Mahon, Petter Olsson and Nicolas Roche

    Citation: Respiratory Research 2017 18:206

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  12. Content type: Research

    Obesity is a risk factor for the development of asthma. In patients with obesity the diagnosis of asthma is often based on symptoms, but without objective measurements. Nevertheless, obesity-associated asthma ...

    Authors: Marise J. Kasteleyn, Tobias N. Bonten, Renée de Mutsert, Willemien Thijs, Pieter S. Hiemstra, Saskia le Cessie, Frits R. Rosendaal, Niels H. Chavannes and Christian Taube

    Citation: Respiratory Research 2017 18:205

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  13. Content type: Research

    The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate th...

    Authors: Sang Hoon Lee, Moo Suk Park, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Woo Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal…

    Citation: Respiratory Research 2017 18:204

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  14. Content type: Review

    Current guidelines recommend a single inhaler maintenance and reliever therapy (SMART) regimen for moderate to severe asthma. However, evidence for the inhaled corticosteroid plus fast-onset-acting β2-agonist (IC...

    Authors: Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J. Barnes and Gang Wang

    Citation: Respiratory Research 2017 18:203

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  15. Content type: Review

    Pulmonary arterial hypertension (PAH) is a chronic pulmonary vascular disease characterized by increased pulmonary vascular resistance (PVR) leading to right ventricular (RV) failure. Autonomic nervous system ...

    Authors: Mylène Vaillancourt, Pamela Chia, Shervin Sarji, Jason Nguyen, Nir Hoftman, Gregoire Ruffenach, Mansoureh Eghbali, Aman Mahajan and Soban Umar

    Citation: Respiratory Research 2017 18:201

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  16. Content type: Research

    Long-acting muscarinic antagonists (LAMAs) are recommended for the treatment of chronic obstructive pulmonary disease (COPD). Glycopyrrolate/eFlow® is an investigational drug–device combination of the LAMA gly...

    Authors: James F. Donohue, Thomas Goodin, Robert Tosiello and Alistair Wheeler

    Citation: Respiratory Research 2017 18:202

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  17. Content type: Research

    Clinical audits have reported considerable variability in COPD medical care and frequent inconsistencies with recommendations. The objectives of this study were to identify factors associated with a better adh...

    Authors: Myriam Calle Rubio, José Luis López-Campos, Juan J. Soler-Cataluña, Bernardino Alcázar Navarrete, Joan B. Soriano, José Miguel Rodríguez González-Moro, Manuel E. Fuentes Ferrer and Juan Luis Rodríguez Hermosa

    Citation: Respiratory Research 2017 18:200

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  18. Content type: Research

    Asthma is characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and airway remodeling. While exposure of house dust mites (HDM) is a common cause of asthma, the pathogenesis of the HD...

    Authors: Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu and Zhou Fu

    Citation: Respiratory Research 2017 18:199

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  19. Content type: Research

    Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive ...

    Authors: Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki and Péter Engelmann

    Citation: Respiratory Research 2017 18:197

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  20. Content type: Review

    According to the current clinical practice guidelines for chronic obstructive pulmonary disease (COPD), the addition of inhaled corticosteroids (ICS) to long-acting β2 agonist therapy is recommended in patients w...

    Authors: Marc Miravitlles, Borja G. Cosío, Aurelio Arnedillo, Myriam Calle, Bernardino Alcázar-Navarrete, Cruz González, Cristóbal Esteban, Juan Antonio Trigueros, José Miguel Rodríguez González-Moro, José Antonio Quintano Jiménez and Adolfo Baloira

    Citation: Respiratory Research 2017 18:198

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  21. Content type: Research

    Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodate...

    Authors: Marc Miravitlles, Gerard Urrutia, Alexander G. Mathioudakis and Julio Ancochea

    Citation: Respiratory Research 2017 18:196

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  22. Content type: Research

    The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling...

    Authors: Shinkichi Ishikawa, Kanae Ishimori and Shigeaki Ito

    Citation: Respiratory Research 2017 18:195

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  23. Content type: Research

    Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of cor...

    Authors: Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo and Kian Fan Chung

    Citation: Respiratory Research 2017 18:194

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  24. Content type: Research

    Despite their growing popularity, the potential respiratory toxicity of electronic cigarettes (e-cigarettes) remains largely unknown. One potential aspect of e-cigarette toxicity is the effect of e-cigarette v...

    Authors: Rebecca J. Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya and Amir M. Farnoud

    Citation: Respiratory Research 2017 18:193

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