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  1. Content type: Research

    Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vit...

    Authors: Lu Wang, Nannan Zhang, Yi Zhang, Jingen Xia, Qingyuan Zhan and Chen Wang

    Citation: Respiratory Research 2018 19:122

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  2. Content type: Review

    The Human Viral Challenge (HVC) model has, for many decades, helped in the understanding of respiratory viruses and their role in disease pathogenesis. In a controlled setting using small numbers of volunteers...

    Authors: Rob Lambkin-Williams, Nicolas Noulin, Alex Mann, Andrew Catchpole and Anthony S. Gilbert

    Citation: Respiratory Research 2018 19:123

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  3. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a progressive disease and a composite endpoint could be an indicator of treatment effect on disease worsening. This post-hoc analysis assessed whether indacatero...

    Authors: Antonio R. Anzueto, Konstantinos Kostikas, Karen Mezzi, Steven Shen, Michael Larbig, Francesco Patalano, Robert Fogel, Donald Banerji and Jadwiga A. Wedzicha

    Citation: Respiratory Research 2018 19:121

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  4. Content type: Research

    Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed that PDGF-BB contracts pulmonary veins (PVs) a...

    Authors: Annette D. Rieg, Said Suleiman, Carolin Anker, Eva Verjans, Rolf Rossaint, Stefan Uhlig and Christian Martin

    Citation: Respiratory Research 2018 19:120

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  5. Content type: Research

    Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Ye...

    Authors: Nuria Toledo-Pons, Guillaume Noell, Andreas Jahn, Amanda Iglesias, Maria Antonia Duran, Julio Iglesias, Angel Rios, Sergio Scrimini, Rosa Faner, Orlando Gigirey, Alvar Agustí and Borja G. Cosío

    Citation: Respiratory Research 2018 19:118

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  6. Content type: Research

    Antimicrobial treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains controversial. In some cases AECOPD are caused by microorganisms that are resistant to treatments recom...

    Authors: Cristina Estirado, Adrian Ceccato, Monica Guerrero, Arturo Huerta, Catia Cilloniz, Olivia Vilaró, Albert Gabarrús, Joaquim Gea, Ernesto Crisafulli, Nestor Soler and Antoni Torres

    Citation: Respiratory Research 2018 19:119

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  7. Content type: Letter to the Editor

    Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated tha...

    Authors: Stella Xu, Emily A. Vucic, Tawimas Shaipanich, Stephen Lam, Wan Lam, Julio S. Montaner, Don D. Sin, S. F. Paul Man and Janice M. Leung

    Citation: Respiratory Research 2018 19:117

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  8. Content type: Correction

    Figure 2 of this original publication was incorrectly formatted. The updated Fig. 2 is published in this correction article [1].

    Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2018 19:116

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    The original article was published in Respiratory Research 2018 19:52

  9. Content type: Review

    Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology. The heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergi...

    Authors: Andrea Matucci, Alessandra Vultaggio, Enrico Maggi and Ismail Kasujee

    Citation: Respiratory Research 2018 19:113

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  10. Content type: Research

    Exposure to high levels of oxygen (hyperoxia) after birth leads to lung injury. Our aims were to investigate the modulation of myeloid cell sub-populations and the reduction of fibrosis in the lungs following ...

    Authors: Ali Al-Rubaie, Andrea F. Wise, Foula Sozo, Robert De Matteo, Chrishan S. Samuel, Richard Harding and Sharon D. Ricardo

    Citation: Respiratory Research 2018 19:114

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  11. Content type: Letter to the Editor

    Although Th2 driven inflammation is present in COPD, it is not clearly elucidated which COPD patients are affected. Since periostin is associated with Th2 driven inflammation and inhaled corticosteroid (ICS)-r...

    Authors: O. A. Carpaij, F. O. W. Muntinghe, M. B. Wagenaar, J. W. Habing, W. Timens, H. A. M. Kerstjens, M. C. Nawijn, L. I. Z. Kunz, P. S. Hiemstra, G. W. Tew, C. T. J. Holweg, C. A. Brandsma and M. van den Berge

    Citation: Respiratory Research 2018 19:112

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  12. Content type: Research

    Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between...

    Authors: Sangeetha Vishweswaraiah, Leema George, Natarajan Purushothaman and Koustav Ganguly

    Citation: Respiratory Research 2018 19:92

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  13. Content type: Research

    Parthenolide (PTL) is a natural molecule isolated from Tanacetum parthenium that exhibits excellent anti-inflammatory and antitumor activities. Pulmonary fibrosis (PF), especially idiopathic pulmonary fibrosis (I...

    Authors: Xiao-he Li, Ting Xiao, Jia-huan Yang, Yuan Qin, Jing-jing Gao, Hui-juan Liu and Hong-gang Zhou

    Citation: Respiratory Research 2018 19:111

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  14. Content type: Research

    Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid withi...

    Authors: Kathrin Kahnert, Peter Alter, Tobias Welte, Rudolf M. Huber, Jürgen Behr, Frank Biertz, Henrik Watz, Robert Bals, Claus F. Vogelmeier and Rudolf A. Jörres

    Citation: Respiratory Research 2018 19:110

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  15. Content type: Research

    Increasing evidence suggests that human antigen R (HuR) is involved in the epithelial-mesenchymal transition (EMT) process of several diseases. However, the role of HuR in EMT in the airway epithelial cells of...

    Authors: Jian Sun, Xianmin Gu, Nan Wu, Pengju Zhang, Yi Liu and Shujuan Jiang

    Citation: Respiratory Research 2018 19:109

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  16. Content type: Research

    Interleukin(IL)-33 is an epithelial alarmin important for eosinophil maturation, activation and survival. The aim of this study was to examine the association between IL-33, its receptor expression and airway ...

    Authors: Damian Tworek, Sebastian Majewski, Karolina Szewczyk, Justyna Kiszałkiewicz, Zofia Kurmanowska, Paweł Górski, Ewa Brzeziańska-Lasota, Piotr Kuna and Adam Antczak

    Citation: Respiratory Research 2018 19:108

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  17. Content type: Research

    Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification ...

    Authors: Kevin Ni, Amar Gill, Victor Tseng, Andrew M. Mikosz, Kengo Koike, Erica L. Beatman, Cassie Y. Xu, Danting Cao, Fabienne Gally, Kara J. Mould, Karina A. Serban, Kelly S. Schweitzer, Keith L. March, William J. Janssen, Eva Nozik-Grayck, Stavros Garantziotis…

    Citation: Respiratory Research 2018 19:107

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  18. Content type: Research

    As a way to determine markers of infection or disease informing disease management, and to reveal disease-associated immune mechanisms, this study sought to measure antibody and T cell responses against key lu...

    Authors: Fathia G. Jaat, Sajidah F. Hasan, Audrey Perry, Sharon Cookson, Santosh Murali, John D. Perry, Clare V. Lanyon, Anthony De Soyza and Stephen M. Todryk

    Citation: Respiratory Research 2018 19:106

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  19. Content type: Research

    Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been ...

    Authors: Elga Bandeira, Helena Oliveira, Johnatas D. Silva, Rubem F. S. Menna-Barreto, Christina M. Takyia, Jung S. Suk, Kenneth W. Witwer, Michael E. Paulaitis, Justin Hanes, Patricia R. M. Rocco and Marcelo M. Morales

    Citation: Respiratory Research 2018 19:104

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  20. Content type: Letter to the Editor

    In idiopathic pulmonary fibrosis (IPF), home monitoring experiences are limited, not yet real-time available nor implemented in daily care. We evaluated feasibility and potential barriers of a new home monitor...

    Authors: C. C. Moor, M. Wapenaar, J. R. Miedema, J. J. M. Geelhoed, P. P. Chandoesing and M. S. Wijsenbeek

    Citation: Respiratory Research 2018 19:105

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  21. Content type: Research

    Extracellular adenosine triphosphate (ATP) is up-regulated in the airways of patients with chronic obstructive pulmonary disease (COPD), resulting in increased inflammation, bronchoconstriction, and cough. Alt...

    Authors: Elisabet Aliagas, Mariana Muñoz-Esquerre, Ester Cuevas, Oriol Careta, Daniel Huertas, Marta López-Sánchez, Ignacio Escobar, Jordi Dorca and Salud Santos

    Citation: Respiratory Research 2018 19:103

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  22. Content type: Research

    Patients with interstitial lung diseases (ILD) have impaired health-related quality of life (HRQL). Little is known about the applicability of the disease-specific King’s Brief Interstitial Lung Disease questi...

    Authors: Boglárka Lilla Szentes, Michael Kreuter, Thomas Bahmer, Surinder S. Birring, Martin Claussen, Julia Waelscher, Reiner Leidl and Larissa Schwarzkopf

    Citation: Respiratory Research 2018 19:101

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  23. Content type: Research

    Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as poten...

    Authors: Liran Levy, Stephen C. Juvet, Kristen Boonstra, Lianne G. Singer, Sassan Azad, Betty Joe, Marcelo Cypel, Shaf Keshavjee and Tereza Martinu

    Citation: Respiratory Research 2018 19:102

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  24. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition in which an important extra-pulmonary manifestation is cardiovascular disease. We hypothesized that COPD patients would have inc...

    Authors: Marie Fisk, Joseph Cheriyan, Divya Mohan, Carmel M. McEniery, Julia Forman, John R. Cockcroft, James H. F. Rudd, Ruth Tal-Singer, Nicholas S. Hopkinson, Michael I. Polkey and Ian B. Wilkinson

    Citation: Respiratory Research 2018 19:100

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