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  1. Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar com...

    Authors: Miguel J. Divo, José M. Marin, Ciro Casanova, Carlos Cabrera Lopez, Victor M. Pinto-Plata, Marta Marin-Oto, Francesca Polverino, Juan P. de-Torres, Dean Billheimer and Bartolome R. Celli
    Citation: Respiratory Research 2022 23:267
  2. Quadriceps muscle weakness and reduced exercise tolerance are prevalent and associated with a worse prognosis in patients with cystic fibrosis (CF). The one-minute sit-to-stand test (1STST) has been proposed t...

    Authors: Sophie Hardy, Silvia Berardis, Anne-Sophie Aubriot, Gregory Reychler and Sophie Gohy
    Citation: Respiratory Research 2022 23:266
  3. Air pollutants can activate low-grade subclinical inflammation which further impairs respiratory health. We aimed to investigate the role of polygenic susceptibility to chronic air pollution-induced subclinica...

    Authors: Sara Kress, Claudia Wigmann, Qi Zhao, Christian Herder, Michael J. Abramson, Holger Schwender and Tamara Schikowski
    Citation: Respiratory Research 2022 23:265
  4. Severe acute respiratory infections (SARI) are the most common infectious causes of death. Previous work regarding mortality prediction models for SARI using machine learning (ML) algorithms that can be useful...

    Authors: Johannes Leiner, Vincent Pellissier, Sebastian König, Sven Hohenstein, Laura Ueberham, Irit Nachtigall, Andreas Meier-Hellmann, Ralf Kuhlen, Gerhard Hindricks and Andreas Bollmann
    Citation: Respiratory Research 2022 23:264
  5. Persistent symptoms after initial COVID-19 infection are common and are frequently referred to by the umbrella terms “post-COVID syndrome” and “long COVID”. The sheer number of affected patients pose an increa...

    Authors: Lucas M. Kimmig, Zvonimir A. Rako, Stefanie Ziegler, Manuel J. Richter, Ashkan Tolou G.S., Fritz Roller, Friedrich Grimminger, István Vadász, Werner Seeger, Susanne Herold, Khodr Tello and Ulrich Matt
    Citation: Respiratory Research 2022 23:263
  6. While optimizing spirometry is a challenge for lung function labs, long-term variability if any between IOS (impulse oscillometry) parameters and spirometry is not clearly known in stable COPD (chronic obstruc...

    Authors: Jianhua Xu, Xingxing Sun, Hanqing Zhu, Yuan Cao, Bigyan Pudasaini, Wenlan Yang, Jinming Liu and Jian Guo
    Citation: Respiratory Research 2022 23:262
  7. Respiratory diseases represent a global health burden. Because research on therapeutic strategies of airway diseases is essential, the technique of precision-cut lung slices (PCLS) has been developed and widel...

    Authors: Sarah Marie Nußbaum, Julia Krabbe, Svenja Böll, Aaron Babendreyer and Christian Martin
    Citation: Respiratory Research 2022 23:261
  8. It has been a long-held consensus that immune reactions primarily mediate the pathology of chronic obstructive pulmonary disease (COPD), and that exosomes may participate in immune regulation in COPD. However,...

    Authors: Yanli Pei, Yuxi Wei, Boshizhang Peng, Mengqi Wang, Wei Xu, Zhe Chen, Xindi Ke and Lei Rong
    Citation: Respiratory Research 2022 23:260
  9. Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung fu...

    Authors: Chun-Chun Gau, Hsin-Ju Lee, Hung-Yi Lu, Chao-Yi Wu, Hsin-Yi Huang, Hui-Ju Tsai and Tsung-Chieh Yao
    Citation: Respiratory Research 2022 23:259
  10. Fluticasone furoate/vilanterol trifenatate (FF/VI) is an inhaled therapy for the treatment of asthma, with a prolonged duration of anti-inflammatory and bronchodilatory action. This study investigated the glob...

    Authors: Peter Daley-Yates, Brian Keppler, Amanda Baines, George Bardsley and James Fingleton
    Citation: Respiratory Research 2022 23:258
  11. Bronchial artery embolisation (BAE) is an effective treatment option to control haemoptysis in primary lung cancer. However, no studies have investigated optimal embolisation material for BAE in lung cancer pa...

    Authors: Jae Hwan Lee, Chang Jin Yoon, Yun Su Jung, Won Seok Choi, Chong-ho Lee and Guy Mok Lee
    Citation: Respiratory Research 2022 23:257
  12. During the COVID-19 pandemic in The Netherlands, critically ill ventilated COVID-19 patients were transferred not only between hospitals by ambulance but also by the Helicopter Emergency Medical Service (HEMS)...

    Authors: Cornelis Slagt, Eduard Johannes Spoelder, Marijn Cornelia Theresia Tacken, Maartje Frijlink, Sjoerd Servaas, Guus Leijte, Lucas Theodorus van Eijk and Geert Jan van Geffen
    Citation: Respiratory Research 2022 23:256
  13. The benefit of prompt vs delayed treatment initiation with inhaled long-acting bronchodilators in reducing exacerbations in chronic obstructive pulmonary disease (COPD) is unclear. This study aimed to investig...

    Authors: Hideyasu Yamada, Isao Matsumoto, Naoyuki Makita, Yoshifumi Arita, Nobuya Hayashi, Kurena Mitsuoka, Naoki Tashiro and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:255
  14. Asthma is the commonest chronic respiratory tract disease in children. In low-income countries, challenges exist in asthma diagnosis. In surveys done in children, the prevalence of ‘asthma’ defined by symptoms...

    Authors: P. Magwenzi, S. Rusakaniko, E. N. Sibanda and F. Z. Gumbo
    Citation: Respiratory Research 2022 23:254
  15. To tested the ability of N-myc and STAT interactor (NMI) levels in patients with community-acquired pneumonia (CAP) to predict the severity of the disease.

    Authors: Wanying Zhang, Hui Zhou, Mengyuan Cen, Wei Ouyang, Jie Chen, Lexin Xia, Xiuhui Lin, Jinliang Liu, Teng He and Feng Xu
    Citation: Respiratory Research 2022 23:253
  16. Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been...

    Authors: Mellissa Gaudet, Maria Plesa, Andrea Mogas, Nour Jalaleddine, Qutayba Hamid and Saba Al Heialy
    Citation: Respiratory Research 2022 23:252
  17. Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA d...

    Authors: Yahui Liu and Guochao Shi
    Citation: Respiratory Research 2022 23:251
  18. No personalized prediction model or standardized algorithm exists to identify those at high risk of death among severe community-acquired pneumonia (SCAP) patients with chronic obstructive pulmonary disease (C...

    Authors: Dong Huang, Dingxiu He, Linjing Gong, Rong Yao, Wen Wang, Lei Yang, Zhongwei Zhang, Qiao He, Zhenru Wu, Yujun Shi and Zongan Liang
    Citation: Respiratory Research 2022 23:250
  19. Acute respiratory distress syndrome (ARDS) is a life-threatening disease caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a dearth of drug applications that can be used t...

    Authors: Funda Terzi, Beste Demirci, İrfan Çınar, Mohammad Alhilal and Huseyin Serkan Erol
    Citation: Respiratory Research 2022 23:249
  20. Single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPAR-γ; gene: PPARG) and oxidative stress genes are associated with asthma risk. However, whether such variants modulate...

    Authors: Clarus Leung, Min Hyung Ryu, Anette Kocbach Bølling, Danay Maestre-Batlle, Christopher F. Rider, Anke Hüls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor and Chris Carlsten
    Citation: Respiratory Research 2022 23:248
  21. The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects, and low CC16 serum levels have been associated with both risk and progression of COPD, yet the interaction between smoking ...

    Authors: Kelli C. Gribben, Jill A. Poole, Amy J. Nelson, Paraskevi A. Farazi, Christopher S. Wichman, Art J. Heires, Debra J. Romberger and Tricia D. LeVan
    Citation: Respiratory Research 2022 23:247
  22. Hypoxic pulmonary hypertension (HPH) is a common complication of chronic lung disease, which severely affects the survival and prognosis of patients. Several recent reports have shown that DNA damage and repai...

    Authors: Ying-ying Liu, Wei-yun Zhang, Meng-lan Zhang, Yu-ji Wang, Xi-yan Ma, Jung-hong Jiang, Ran Wang and Da-xiong Zeng
    Citation: Respiratory Research 2022 23:246
  23. A feasible and economical bronchoscopic navigation method in guiding peripheral pulmonary nodule biopsy is lacking.

    Authors: Chang-Hao Zhong, Zhu-Quan Su, Wei-Zhan Luo, Wan-Yuan Rao, Jia-Xin Feng, Chun-Li Tang, Yu Chen, Xiao-Bo Chen, Ming-Yue Fan and Shi-Yue Li
    Citation: Respiratory Research 2022 23:245
  24. Epithelial–mesenchymal transition (EMT) is one of the mechanisms of airway remodeling in chronic asthma. Interleukin (IL)-24 has been implicated in the promotion of tissue fibrosis, and increased IL-24 levels ...

    Authors: Kang-ni Feng, Ping Meng, Xiao-ling Zou, Min Zhang, Hai-ke Li, Hai-ling Yang, Hong-tao Li and Tian-tuo Zhang
    Citation: Respiratory Research 2022 23:244
  25. Asthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or without wheezing. We compared the clinical and pathophysiological character...

    Authors: Jianmeng Zhou, Fang Yi, Feng Wu, Pusheng Xu, Meihua Chen, Huahao Shen, Lin Lin, Yunhui Zhang, Suyun Li, Changgui Wu, Yadong Yuan, Gang Wang, Xianwei Ye, Ping Zhang, Huaping Tang, Qianli Ma…
    Citation: Respiratory Research 2022 23:243
  26. The coronavirus disease (COVID-19) pandemic has already affected more than 400 million people, with increasing numbers of survivors. These data indicate that a myriad of people may be affected by pulmonary seq...

    Authors: Julia Tarraso, Belen Safont, Juan A. Carbonell-Asins, Estrella Fernandez-Fabrellas, José N. Sancho-Chust, Elsa Naval, Beatriz Amat, Susana Herrera, José A. Ros, Juan J. Soler-Cataluña, Jose A. Rodriguez-Portal, Ada L. Andreu, Margarita Marín, Juan L. Rodriguez-Hermosa, Cruz Gonzalez-Villaescusa, Joan B. Soriano…
    Citation: Respiratory Research 2022 23:242
  27. Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and...

    Authors: Liza Pereverzeva, Natasja A. Otto, Joris J. T. H. Roelofs, Alex F. de Vos and Tom van der Poll
    Citation: Respiratory Research 2022 23:241
  28. To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to the Cartwright Classification (CC) and Amst...

    Authors: Weijun Huang, Xiaoting Wang, Chong Xu, Huajun Xu, Huaming Zhu, Suru Liu, Jianyin Zou, Jian Guan, Hongliang Yi and Shankai Yin
    Citation: Respiratory Research 2022 23:240
  29. Despite improvements in medical science and public health, mortality of community-acquired pneumonia (CAP) has barely changed throughout the last 15 years. The current SARS-CoV-2 pandemic has once again highli...

    Authors: Mathias W. Pletz, Andreas Vestergaard Jensen, Christina Bahrs, Claudia Davenport, Jan Rupp, Martin Witzenrath, Grit Barten-Neiner, Martin Kolditz, Sabine Dettmer, James D. Chalmers, Daiana Stolz, Norbert Suttorp, Stefano Aliberti, Wolfgang M. Kuebler and Gernot Rohde
    Citation: Respiratory Research 2022 23:239
  30. Foreign body aspiration (FBA) is a serious condition with high morbidity and mortality rates. Although chest radiography is generally the first radiologic modality used in diagnosis, a substantial percentage o...

    Authors: Xiaofan Liu, Fang Ni, Tao Guo, Fangfang Jiang, Yan Jiang, Cheng Song, Mingli Yuan, Zhaowu Tao, Mingxin Ye, Junjie Xu, Ying Wang, Qiong Qian, Yi Hu and Yihua Wang
    Citation: Respiratory Research 2022 23:238
  31. Transcriptomic analysis has been used to elucidate the complex pathogenesis of heterogeneous disease and may also contribute to identify potential therapeutic targets by delineating the hub genes. This study a...

    Authors: Hyun Woo Lee, Min-gyung Baek, Sungmi Choi, Yoon Hae Ahn, Ji-Young Bang, Kyoung-Hee Sohn, Min-Gyu Kang, Jae-Woo Jung, Jeong-Hee Choi, Sang-Heon Cho, Hana Yi and Hye-Ryun Kang
    Citation: Respiratory Research 2022 23:237
  32. The role of wood smoke (WS) exposure in the etiology of chronic obstructive pulmonary disease (COPD), lung cancer (LC), and mortality remains elusive in adults from countries with low ambient levels of combust...

    Authors: Shuguang Leng, Maria A. Picchi, Paula M. Meek, Menghui Jiang, Samuel H. Bayliss, Ting Zhai, Ruslan I. Bayliyev, Yohannes Tesfaigzi, Matthew J. Campen, Huining Kang, Yiliang Zhu, Qing Lan, Akshay Sood and Steven A. Belinsky
    Citation: Respiratory Research 2022 23:236
  33. Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with decline in lung function and poor prognosis entailing significant impairment in quality of life and high socioeconomic burden. The a...

    Authors: Esteban Cano-Jiménez, Ana Dolores Romero Ortiz, Ana Villar, María Jesús Rodríguez-Nieto, Alba Ramon and Silvia Armengol
    Citation: Respiratory Research 2022 23:235
  34. Authors: Lourdes Chacon-Alberty, Shengbin Ye, Daoud Daoud, William C. Frankel, Hassan Virk, Jonathan Mase, Camila Hochman-Mendez, Meng Li, Luiz C. Sampaio, Doris A. Taylor and Gabriel Loor
    Citation: Respiratory Research 2022 23:234

    The original article was published in Respiratory Research 2021 22:318

  35. Some coronavirus disease 2019 (COVID-19) survivors experience prolonged and varying symptoms, a condition termed post-acute COVID-19 syndrome (PACS). However, the prevalence of chronic pulmonary sequelae of PA...

    Authors: Jong Hyuk Lee, Jae-Joon Yim and Jimyung Park
    Citation: Respiratory Research 2022 23:233
  36. Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepa...

    Authors: Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi and Mark Brantly
    Citation: Respiratory Research 2022 23:232
  37. Multiple inhaler triple therapy (MITT), comprising inhaled corticosteroids (ICS), long-acting beta-agonists (LABA), and long-acting muscarinic antagonists (LAMA), has been used as an escalation treatment for p...

    Authors: Chang-Hoon Lee, Mi-Sook Kim, See-Hwee Yeo, Chin-Kook Rhee, Heung-Woo Park, Bo-Ram Yang, Joongyub Lee, Eun-Yeong Cho, Xiaomeng Xu, Aldo Amador Navarro Rojas, Sumitra Shantakumar, Dominique Milea and Nam-Kyong Choi
    Citation: Respiratory Research 2022 23:231
  38. Imbalance in l-arginine and nitric oxide (NO) metabolism has been implicated in the pathophysiology of asthma and obstructive sleep apnea (OSA), and both diseases impact the other’s morbidity. We sought to determ...

    Authors: Meghan D. Althoff, Guillermo Jimenez, Ryan Peterson, Ying Jin, Hartmut Grasemann, Sunita Sharma, Alex D. Federman, Juan P. Wisnivesky and Fernando Holguin
    Citation: Respiratory Research 2022 23:230
  39. Aging has been evidenced to bring about some structural and functional lung changes, especially in COPD. However, whether aging affects SAD, a possible precursor of COPD, has not been well characterized.

    Authors: Cuiqiong Dai, Fan Wu, Zihui Wang, Jieqi Peng, Huajing Yang, Youlan Zheng, Lifei Lu, Ningning Zhao, Zhishan Deng, Shan Xiao, Xiang Wen, Jianwu Xu, Peiyu Huang, Kunning Zhou, Xiaohui Wu, Yumin Zhou…
    Citation: Respiratory Research 2022 23:229
  40. Sarcopenia gained importance in the evaluation of patients with chronic respiratory diseases, including idiopathic pulmonary fibrosis (IPF), since it may impact negatively on clinical outcomes.

    Authors: Paola Faverio, Alessia Fumagalli, Sara Conti, Fabiana Madotto, Francesco Bini, Sergio Harari, Michele Mondoni, Tiberio Oggionni, Emanuela Barisione, Paolo Ceruti, Maria Chiara Papetti, Bruno Dino Bodini, Antonella Caminati, Angela Valentino, Stefano Centanni, Paola Lanzi…
    Citation: Respiratory Research 2022 23:228
  41. Despite the well-known detrimental effects of cigarette smoke (CS), little is known about the complex gene expression dynamics in the early stages after exposure. This study aims to investigate early transcrip...

    Authors: Anne M. van der Does, Rashad M. Mahbub, Dennis K. Ninaber, Senani N. H. Rathnayake, Wim Timens, Maarten van den Berge, Hananeh Aliee, Fabian J. Theis, Martijn C. Nawijn, Pieter S. Hiemstra and Alen Faiz
    Citation: Respiratory Research 2022 23:227
  42. Patients with interstitial lung disease (ILD) are at high risk of severe COVID-19 infection. Additionally, their anti-inflammatory and antifibrotic treatment may cause immunosuppression. Nevertheless, their ab...

    Authors: Barak Pertzov, Einat Shmueli, Haim Ben Zvi, Amir Massarweh, Tamar Barkan, Asaf Ness, Yael Shostak, Lev Freidkin, Osnat Shtraichman and Mordechai R. Kramer
    Citation: Respiratory Research 2022 23:226
  43. Cigarette smoke is a complex aerosol containing a large number of compounds with a variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly increases the risk of a variety o...

    Authors: Xiaoshan Su, Weijing Wu, Zhixing Zhu, Xiaoping Lin and Yiming Zeng
    Citation: Respiratory Research 2022 23:225
  44. Surgery is the mainstay of treatment for non-small cell lung cancer, but the decline in pulmonary function after surgery is noticeable and requires attention. This study aimed to evaluate longitudinal changes ...

    Authors: Sumin Shin, Sunga Kong, Danbee Kang, Genehee Lee, Jong Ho Cho, Young Mog Shim, Juhee Cho, Hong Kwan Kim and Hye Yun Park
    Citation: Respiratory Research 2022 23:224
  45. Pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) is recognized as a cancer-like disease with a proliferative and pro-migratory phenotype in pulmonary artery smooth muscle cell...

    Authors: Jingjing Zhou, FuRong Li and Yicheng Yang
    Citation: Respiratory Research 2022 23:223
  46. Although asthma is more prevalent in women and the prevalence of COPD is increasing in women, the current international recommendations for the management and prevention of asthma and COPD provide no sex-relat...

    Authors: Paola Rogliani, Francesco Cavalli, Beatrice Ludovica Ritondo, Mario Cazzola and Luigino Calzetta
    Citation: Respiratory Research 2022 23:222
  47. Mid-Regional pro-Adrenomedullin (MR-proADM) is an inflammatory biomarker that improves the prognostic assessment of patients with sepsis, septic shock and organ failure. Previous studies of MR-proADM have prim...

    Authors: Emanuela Sozio, Nathan A. Moore, Martina Fabris, Andrea Ripoli, Francesca Rumbolo, Marilena Minieri, Riccardo Boverio, María Dolores Rodríguez Mulero, Sara Lainez-Martinez, Mónica Martínez Martínez, Dolores Calvo, Claudia Gregoriano, Rebecca Williams, Luca Brazzi, Alessandro Terrinoni, Tiziana Callegari…
    Citation: Respiratory Research 2022 23:221
  48. Early appropriate diagnosis and treatment of interstitial lung diseases (ILD) is crucial to slow disease progression and improve survival. Yet it is unknown whether initial management in an expert centre is as...

    Authors: Pavo Marijic, Larissa Schwarzkopf, Werner Maier, Franziska Trudzinski, Michael Kreuter and Lars Schwettmann
    Citation: Respiratory Research 2022 23:220
  49. Bronchoalveolar lavage (BAL) is a key tool in respiratory medicine for sampling the distal airways. BAL bile acids are putative biomarkers of pulmonary microaspiration, which is associated with poor outcomes a...

    Authors: Chen Yang Kevin Zhang, Musawir Ahmed, Ella Huszti, Liran Levy, Sarah E. Hunter, Kristen M. Boonstra, Sajad Moshkelgosha, Andrew T. Sage, Sassan Azad, Rasheed Ghany, Jonathan C. Yeung, Oscar M. Crespin, Lianne G. Singer, Shaf Keshavjee and Tereza Martinu
    Citation: Respiratory Research 2022 23:219
  50. Authors: Jin Yang, Libing Ma, Li Guo, Ting Zhang, Zhiwei Leng, Mengmeng Jia, Fangyuan Chen, Weiran Qi, Xingxing Zhang, Qing Wang, Yuan Yang, Luzhao Feng, Lili Ren, Weizhong Yang and Chen Wang
    Citation: Respiratory Research 2022 23:218

    The original article was published in Respiratory Research 2022 23:188

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