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  1. Content type: Research

    Candidate gene and genome-wide association studies have identified hundreds of asthma risk loci. The majority of associated variants, however, are not known to have any biological function and are believed to ...

    Authors: Matthew D. C. Neville, Jihoon Choi, Jonathan Lieberman and Qing Ling Duan

    Citation: RESPIRATORY RESEARCH 2018 19:248

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  2. Content type: Research

    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity stage classifies Chronic Obstructive Pulmonary Disease (COPD) into groups based on symptoms, exacerbations and forced expiratory volum...

    Authors: Robert W. V. Flynn, Thomas M. MacDonald, James D. Chalmers and Stuart Schembri

    Citation: RESPIRATORY RESEARCH 2018 19:249

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  3. Content type: Research

    Few studies have investigated the associations between outdoor air pollution and outpatient visits for respiratory diseases (RDs) in general population.

    Authors: Shanshan Wang, Yifan Li, Aimin Niu, Yao Liu, Lili Su, Wanmei Song, Jinyue Liu, Yunxia Liu and Huaichen Li

    Citation: RESPIRATORY RESEARCH 2018 19:246

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  4. Content type: Research

    Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying ...

    Authors: Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell…

    Citation: RESPIRATORY RESEARCH 2018 19:245

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  5. Content type: Research

    Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in l...

    Authors: Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht and Annelie F. Behndig

    Citation: RESPIRATORY RESEARCH 2018 19:244

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  6. Content type: Research

    Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissu...

    Authors: Huaizheng Liu, Kefu Zhou, Liangkan Liao, Tianyi Zhang, Mingshi Yang and Chuanzheng Sun

    Citation: RESPIRATORY RESEARCH 2018 19:243

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  7. Content type: Research

    Cirrhosis always goes with profound immunity compromise, and makes those patients easily be the target of pneumonia. Cirrhotic patients with pneumonia have a dramatically increased mortality. To recognize the ...

    Authors: Lichen Xu, Shuangwei Ying, Jianhua Hu, Yunyun Wang, Meifang Yang, Tiantian Ge, Chunhong Huang, Qiaomai Xu, Haihong Zhu, Zhi Chen and Weihang Ma

    Citation: RESPIRATORY RESEARCH 2018 19:242

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  8. Content type: Research

    The main causes of COPD are tobacco smoking (COPD-TS) and biomass smoke exposure (COPD-BS). COPD-TS is known to induce changes in adipokines, incretins, and peptide hormones, frequent biomarkers of inflammatio...

    Authors: Oliver Pérez-Bautista, Martha Montaño, Rogelio Pérez-Padilla, Joaquín Zúñiga-Ramos, Mariana Camacho-Priego, Tonatiuh Barrientos-Gutiérrez, Ivette Buendía-Roldan, Yadira Velasco-Torres and Carlos Ramos

    Citation: RESPIRATORY RESEARCH 2018 19:239

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  9. Content type: Research

    Different histological subtypes of non-small cell lung cancer (NSCLC) show different molecular characteristics and responses to therapeutic strategy. Identification of specific gene, clarification of its speci...

    Authors: Fei Han, Ming-qian Zhang, Wen-bin Liu, Lei Sun, Xiang-lin Hao, Li Yin, Xiao Jiang, Jia Cao and Jin-yi Liu

    Citation: RESPIRATORY RESEARCH 2018 19:241

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  10. Content type: Research

    Ex vivo lung perfusion (EVLP) is used by an increasing number of transplant centres. It is still controversial whether an acellular or cellular (erythrocyte enriched) perfusate is preferable. The aim of this p...

    Authors: Jasmin Steinmeyer, Simon Becker, Murat Avsar, Jawad Salman, Klaus Höffler, Axel Haverich, Gregor Warnecke, Christian Mühlfeld, Matthias Ochs and Anke Schnapper-Isl

    Citation: RESPIRATORY RESEARCH 2018 19:238

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  11. Content type: Research

    Adrenal hormone metabolite levels are altered in acute illnesses such as community-acquired pneumonia (CAP). Our aim was to investigate associations of sex and mineralocorticoid hormone metabolites with short-...

    Authors: Seline Zurfluh, Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz

    Citation: RESPIRATORY RESEARCH 2018 19:240

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  12. Content type: Research

    Sarcoidosis is a systemic inflammatory multi-organ disease almost always affecting the lungs. The etiology remains unknown, but the hallmark of sarcoidosis is formation of non-caseating epithelioid cells granu...

    Authors: Marcus O. D. Sjödin, Antonio Checa, Mingxing Yang, Sven-Erik Dahlén, Åsa M. Wheelock, Anders Eklund, Johan Grunewald and Craig E. Wheelock

    Citation: RESPIRATORY RESEARCH 2018 19:236

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  13. Content type: Research

    The burden of asthma and COPD among patients is high and people affected are frequently hospitalized due to exacerbations. There are numerous reasons for the lack of disease control in asthma and COPD patients...

    Authors: Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Sabrina Maier, Isabelle Arnet, Kurt E. Hersberger and Jörg D. Leuppi

    Citation: RESPIRATORY RESEARCH 2018 19:237

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  14. Content type: Research

    Either chronic or acute exposure to dust particles may lead to pneumoconiosis and lung cancer, and lung cancer mortality among patients diagnosed with pneumoconiosis is increasing. Utilizing genome-wide sequen...

    Authors: Lin Zhang, Changfu Hao, Ruonan Zhai, Di Wang, Jianhui Zhang, Lei Bao, Yiping Li and Wu Yao

    Citation: Respiratory Research 2018 19:235

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  15. Content type: Research

    Individuals with respiratory disease are being increasingly exposed to wildfire smoke as populations encroach further into forested regions and climate change continues to bring higher temperatures with lower ...

    Authors: Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, Paul N. Reynolds and Sandra Hodge

    Citation: Respiratory Research 2018 19:234

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  16. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterized by progressive scarring of the lung parenchyma, leading to respiratory failure and death. High resolution computed tomography of the chest is often diagnost...

    Authors: Marc A. Sala, Yalbi Itzel Balderas-Martínez, Ivette Buendía-Roldan, Hiam Abdala-Valencia, Kiwon Nam, Manu Jain, Sangeeta Bhorade, Ankit Bharat, Paul A. Reyfman, Karen M. Ridge, Annie Pardo, Jacob I. Sznajder, G. R. Scott Budinger, Alexander V. Misharin and Moises Selman

    Citation: Respiratory Research 2018 19:233

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  17. Content type: Research

    Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other st...

    Authors: Feng Li, Mengmeng Xu, Muyun Wang, Lei Wang, Hanying Wang, Hai Zhang, Yuqing Chen, Jicheng Gong, Junfeng(Jim) Zhang, Ian M. Adcock, Kian Fan Chung and Xin Zhou

    Citation: Respiratory Research 2018 19:230

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  18. Content type: Research

    Sepsis is a multi-system syndrome that remains the leading cause of mortality and critical illness worldwide, with hemodynamic support being one of the cornerstones of the acute management of sepsis. We used a...

    Authors: Margaret R. Passmore, Liam Byrne, Nchafatso G. Obonyo, Louise E. See Hoe, Ai-Ching Boon, Sara D. Diab, Kimble R. Dunster, Kavita Bisht, John-Paul Tung, Mohd H. Fauzi, Monica Narula, Sanne E. Pedersen, Arlanna Esguerra-Lallen, Gabriela Simonova, Annette Sultana, Chris M. Anstey…

    Citation: Respiratory Research 2018 19:231

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  19. Content type: Research

    Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships.

    Authors: Toby C. Lewis, Ediri E. Metitiri, Graciela B. Mentz, Xiaodan Ren, Ashley R. Carpenter, Adam M. Goldsmith, Kyra E. Wicklund, Breanna N. Eder, Adam T. Comstock, Jeannette M. Ricci, Sean R. Brennan, Ginger L. Washington, Kendall B. Owens, Bhramar Mukherjee, Thomas G. Robins, Stuart A. Batterman…

    Citation: Respiratory Research 2018 19:228

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  20. Content type: Research

    Endobronchial administration of lidocaine is commonly used for cough suppression during diagnostic bronchoscopy. Recently, nebulization of lidocaine during bronchoscopies under deep sedation with fiberoptic in...

    Authors: Tobias Müller, Christian Cornelissen and Michael Dreher

    Citation: Respiratory Research 2018 19:227

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  21. Content type: Research

    Hyperoxia is a frequently employed therapy for prematurely born infants, induces lung injury and contributes to development of bronchopulmonary dysplasia (BPD). BPD is characterized by decreased cellular proli...

    Authors: Mehboob Ali, Kathryn Heyob, Trent E. Tipple, Gloria S. Pryhuber and Lynette K. Rogers

    Citation: Respiratory Research 2018 19:229

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  22. Content type: Research

    Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD a...

    Authors: Javier Milara, Lucía Díaz-Platas, Sonia Contreras, Pilar Ribera, Inés Roger, Beatriz Ballester, Paula Montero, Ángel Cogolludo, Esteban Morcillo and Julio Cortijo

    Citation: Respiratory Research 2018 19:226

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  23. Content type: Research

    The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity ...

    Authors: Cheryl S. Pirozzi, Tian Gu, Pedro M. Quibrera, Elizabeth E. Carretta, MeiLan K. Han, Susan Murray, Christopher B. Cooper, Donald P. Tashkin, Eric C. Kleerup, Igor Barjaktarevic, Eric A. Hoffman, Carlos H. Martinez, Stephanie A. Christenson, Nadia N. Hansel, R. Graham Barr, Eugene R. Bleecker…

    Citation: Respiratory Research 2018 19:223

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  24. Content type: Research

    Difference between combined inspiratory and expiratory muscle training in same respiratory cycle or different cycles remained unclarified. We explored the difference between both patterns of combined trainings...

    Authors: Wenhui Xu, Rui Li, Lili Guan, Kai Wang, Yuhe Hu, Limei Xu, Luqian Zhou, Rongchang Chen and Xin Chen

    Citation: Respiratory Research 2018 19:225

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  25. Content type: Research

    A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1 s (FEV1) versus once-daily tiotropium/olodaterol (TIO/...

    Authors: M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río and N. A. Risebrough

    Citation: Respiratory Research 2018 19:224

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  26. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by varying trajectories of decline. Information regarding the prognostic value of preventing short-term clinically important deterioration (CID) in...

    Authors: Ian P. Naya, Lee Tombs, Hana Muellerova, Christopher Compton and Paul W. Jones

    Citation: Respiratory Research 2018 19:222

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  27. Content type: Research

    Endothelial barrier dysfunction is central to the pathogenesis of sepsis-associated acute lung injury (ALI). Microtubule (MT) dynamics in vascular endothelium are crucial for the regulation of endothelial barr...

    Authors: Shengtian Mu, Yina Liu, Jing Jiang, Renyu Ding, Xu Li, Xin Li and Xiaochun Ma

    Citation: Respiratory Research 2018 19:220

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  28. Content type: Research

    Pulmonary complications are common in primary immunodeficiency diseases (PID) and contribute to morbidity and mortality in these patients. However, their varied presentation and a general lack of awareness of ...

    Authors: Pere Soler-Palacín, Javier de Gracia, Luis Ignacio González-Granado, Carlos Martín, Carlos Rodríguez-Gallego, Silvia Sánchez-Ramón and Lung ID-Signal Group

    Citation: Respiratory Research 2018 19:219

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  29. Content type: Review

    Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells. Their therapeutic potential appears promising as evide...

    Authors: Arezoo Mohammadipoor, Ben Antebi, Andriy I. Batchinsky and Leopoldo C. Cancio

    Citation: Respiratory Research 2018 19:218

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  30. Content type: Review

    Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists are novel agents for asthma but with controversial efficacies in clinical trials. Therefore, we conducted a meta-analysis...

    Authors: Jing Yang, Jian Luo, Ling Yang, Dan Yang, Dan Wang, Bicui Liu, Tingxuan Huang, Xiaohu Wang, Binmiao Liang and Chuntao Liu

    Citation: Respiratory Research 2018 19:217

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  31. Content type: Research

    The soluble receptor for advanced glycation end-products (sRAGE) has been suggested that it acts as a decoy for capturing advanced glycation end-products (AGEs) and inhibits the activation of the oxidative str...

    Authors: Carlos Machahua, Ana Montes-Worboys, Lurdes Planas-Cerezales, Raquel Buendia-Flores, Maria Molina-Molina and Vanesa Vicens-Zygmunt

    Citation: Respiratory Research 2018 19:215

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  32. Content type: Research

    The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH).

    Authors: Lukas Fischer, Nicola Benjamin, Norbert Blank, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Maria Koegler, Hanns-Martin Lorenz, Alberto M. Marra, Christian Nagel, Panagiota Xanthouli, Eduardo Bossone and Ekkehard Grünig

    Citation: Respiratory Research 2018 19:216

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  33. Content type: Research

    The potential effects of pulmonary dysfunction on cardiovascular diseases (CVD) are receiving attention. We aimed to investigate and quantify the cross-sectional and longitudinal associations between lung func...

    Authors: Bin Wang, Yun Zhou, Lili Xiao, Yanjun Guo, Jixuan Ma, Min Zhou, Tingming Shi, Aijun Tan, Jing Yuan and Weihong Chen

    Citation: Respiratory Research 2018 19:214

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  34. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim...

    Authors: J. Clukers, M. Lanclus, B. Mignot, C. Van Holsbeke, J. Roseman, S. Porter, E. Gorina, E. Kouchakji, K. E. Lipson, W. De Backer and J. De Backer

    Citation: Respiratory Research 2018 19:213

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  35. Content type: Research

    The obesity paradox in COPD describes protective effects of obesity on lung pathology and inflammation. However, the underlying relationships between obesity, diet and disease outcomes in COPD are not fully un...

    Authors: Sandra Rutting, Michael Papanicolaou, Dia Xenaki, Lisa G. Wood, Alexander M. Mullin, Philip M. Hansbro and Brian G. Oliver

    Citation: Respiratory Research 2018 19:211

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  36. Content type: Research

    Genetic and environmental factors play a role in the development of COPD. The epigenome, and more specifically DNA methylation, is recognized as important link between these factors. We postulate that DNA meth...

    Authors: Maaike de Vries, Diana A van der Plaat, Ivana Nedeljkovic, Rikst Nynke Verkaik-Schakel, Wierd Kooistra, Najaf Amin, Cornelia M van Duijn, Corry-Anke Brandsma, Cleo C van Diemen, Judith M Vonk and H Marike Boezen

    Citation: Respiratory Research 2018 19:212

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  37. Content type: Research

    Aspirin-exacerbated respiratory disease (AERD) is a distinct eosinophilic phenotype of severe asthma with accompanying chronic rhinosinusitis, nasal polyposis, and hypersensitivity to aspirin. Urinary 3-bromot...

    Authors: Suzy A. A. Comhair, Grazyna Bochenek, Sara Baicker-McKee, Zeneng Wang, Tomasz Stachura, Marek Sanak, Jeffrey P. Hammel, Stanley L. Hazen, Serpil C. Erzurum and Ewa Nizankowska-Mogilnicka

    Citation: Respiratory Research 2018 19:210

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  38. Content type: Review

    Rhinovirus (RV) exposure has been implicated in childhood development of wheeze evoking asthma and exacerbations of underlying airways disease. Studies such as the Copenhagen Prospective Studies on Asthma in C...

    Authors: Dennis Lo, Joshua L. Kennedy, Richard C. Kurten, Reynold A. Panettieri Jr and Cynthia J. Koziol-White

    Citation: Respiratory Research 2018 19:208

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  39. Content type: Research

    Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood as...

    Authors: Lystra P. Hayden, Michael H. Cho, Benjamin A. Raby, Terri H. Beaty, Edwin K. Silverman and Craig P. Hersh

    Citation: Respiratory Research 2018 19:209

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  40. Content type: Research

    The microenvironment (ME) of neuroepithelial bodies (NEBs) harbors densely innervated groups of pulmonary neuroendocrine cells that are covered by Clara-like cells (CLCs) and is believed to be important during...

    Authors: Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns and Dirk Adriaensen

    Citation: Respiratory Research 2018 19:207

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  41. Content type: Research

    The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration. FBXO17 was recently identified as...

    Authors: Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli and Yutong Zhao

    Citation: Respiratory Research 2018 19:206

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  42. Content type: Research

    Pneumonia is a relevant clinical and public health issue worldwide frequently associated with infections caused by Multi-Drug Resistant (MDR) pathogens. Ceftaroline fosamil is a promising new antibiotics with ...

    Authors: Giovanni Sotgiu, Stefano Aliberti, Andrea Gramegna, Marco Mantero, Marta Di Pasquale, Federica Trogu, Laura Saderi and Francesco Blasi

    Citation: Respiratory Research 2018 19:205

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  43. Content type: Letter to the editor

    Type II alveolar epithelial cells (AT2) play a pivotal role in maintaining the integrity and function of the alveoli. Only recently, the role of impaired epithelial repair mechanisms after injury in the pathog...

    Authors: Petra Khan, Kleanthis Fytianos, Luca Tamò, Michael Roth, Michael Tamm, Thomas Geiser, Amiq Gazdhar and Katrin E Hostettler

    Citation: Respiratory Research 2018 19:204

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  44. Content type: Review

    High-flow nasal cannula (HFNC) can be used as an initial support strategy for patients with acute respiratory failure (ARF) and after extubation. However, no clear evidence exists to support or oppose HFNC use...

    Authors: Zhiheng Xu, Yimin Li, Jianmeng Zhou, Xi Li, Yongbo Huang, Xiaoqing Liu, Karen E. A. Burns, Nanshan Zhong and Haibo Zhang

    Citation: Respiratory Research 2018 19:202

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  45. Content type: Research

    The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact...

    Authors: Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai and Fei Xiao

    Citation: Respiratory Research 2018 19:201

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