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  1. Content type: Research

    Respiratory pathology is a major driver of mortality in the intensive care unit (ICU), even in the absence of a primary respiratory diagnosis. Prior work has demonstrated that a visual scoring system applied t...

    Authors: Stefanie E. Mason, Paul B. Dieffenbach, Joshua A. Englert, Angela A. Rogers, Anthony F. Massaro, Laura E. Fredenburgh, Angelica Higuera, Mayra Pinilla-Vera, Marta Vilas, Raul San Jose Estepar, George R. Washko, Rebecca M. Baron and Samuel Y. Ash

    Citation: Respiratory Research 2019 20:218

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  2. Content type: Research

    Icotinib has been widely used in patients with non-small cell lung cancer (NSCLC), and have significantly enhanced the overall survival rate of NSCLC patients. However, acquired drug resistance limits its clin...

    Authors: Yiming Yu, Maidinaimu Abudula, Chaofen Li, Zhongbo Chen, Yun Zhang and Yichen Chen

    Citation: Respiratory Research 2019 20:217

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  3. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolu...

    Authors: Bora Sul, Lucia Flors, Joanne Cassani, Michael J. Morris, Jaques Reifman, Talissa Altes and Anders Wallqvist

    Citation: Respiratory Research 2019 20:216

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  4. Content type: Research

    Evidence on the economic impact of chronic obstructive pulmonary disease (COPD) for third-party payers and society based on large real world datasets are still scarce. Therefore, the aim of this study was to e...

    Authors: Florian Kirsch, Anja Schramm, Larissa Schwarzkopf, Johanna I. Lutter, Boglárka Szentes, Manuel Huber and Reiner Leidl

    Citation: Respiratory Research 2019 20:215

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  5. Content type: Research

    There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation be...

    Authors: Jian Liu, Yong-Quan Dong, Jie Yin, Jian Yao, Jie Shen, Guo-Jie Sheng, Kun Li, Hai-Feng Lv, Xing Fang and Wei-Fang Wu

    Citation: Respiratory Research 2019 20:161

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  6. Content type: Research

    At present, there are few methods available for monitoring respiratory diseases affecting distal airways. Bronchoscopy is the golden standard for sampling the lower airways. The recently developed method for c...

    Authors: Annelie F. Behndig, Ekaterina Mirgorodskaya, Anders Blomberg and Anna-Carin Olin

    Citation: Respiratory Research 2019 20:214

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  7. Content type: Research

    The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect...

    Authors: Ryoung-Eun Ko, Soo Jin Na, Kyungmin Huh, Gee Young Suh and Kyeongman Jeon

    Citation: Respiratory Research 2019 20:213

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  8. Content type: Research

    Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in ...

    Authors: Panayiotis Kouis, Myrofora Goutaki, Florian S. Halbeisen, Ifigeneia Gioti, Nicos Middleton, Israel Amirav, Angelo Barbato, Laura Behan, Mieke Boon, Nagehan Emiralioglu, Eric G. Haarman, Bulent Karadag, Cordula Koerner-Rettberg, Romain Lazor, Michael R. Loebinger, Bernard Maitre…

    Citation: Respiratory Research 2019 20:212

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  9. Content type: Research

    Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. Lung function measurement is a key step i...

    Authors: Eline Bonnardel, Renaud Prevel, Marilyne Campagnac, Marielle Dubreuil, Roger Marthan, Patrick Berger and Isabelle Dupin

    Citation: Respiratory Research 2019 20:211

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  10. Content type: Research

    Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and asthma are associated with a variety of precipitating factors including infection. This study assessed the infective viral etiologies b...

    Authors: Fanny Wai-san Ko, Paul Kay-sheung Chan, Renee W. Y. Chan, Ka-Pang Chan, April Ip, Angela Kwok, Jenny Chun-li Ngai, So-Shan Ng, Chan Tat On and David Shu-cheong Hui

    Citation: Respiratory Research 2019 20:210

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  11. Content type: Letter to the Editor

    Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capaci...

    Authors: Marie-Caroline Rotty, Jean-Pierre Mallet, Carey M. Suehs, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel

    Citation: Respiratory Research 2019 20:209

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  12. Content type: Research

    Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Pr...

    Authors: R. James White, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Ronald J. Oudiz, Vallerie V. McLaughlin, Marius M. Hoeper, Ekkehard Grünig, Hossein-Ardeschir Ghofrani, Murali M. Chakinala, Joan A. Barberà, Christiana Blair, Jonathan Langley and Adaani E. Frost

    Citation: Respiratory Research 2019 20:208

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  13. Content type: Research

    The diagnostic yield of peripheral pulmonary lesions has significantly increased with the use of radial endobronchial ultrasound with guide sheath within the lesion. Here, we retrospectively evaluated factors ...

    Authors: Yoichi Nishii, Taro Yasuma, Kentaro Ito, Yuta Suzuki, Fumiaki Watanabe, Tetsu Kobayashi, Kota Nishihama, Corina N. D’Alessandro-Gabazza, Hajime Fujimoto, Esteban C. Gabazza, Fumihiro Asano, Osamu Taguchi and Osamu Hataji

    Citation: Respiratory Research 2019 20:207

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  14. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe and w...

    Authors: Tuong N. Vu, Xuesong Chen, Hussein D. Foda, Gerald C. Smaldone and Nadia A. Hasaneen

    Citation: Respiratory Research 2019 20:206

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  15. Content type: Research

    Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into Type 1 alveolar epithelial cells (AT1s). In the prese...

    Authors: Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Diana Feller, Veronika Csongei, Szilard Pal, Domokos Bartis, David R. Thickett and Judit Erzsebet Pongracz

    Citation: Respiratory Research 2019 20:204

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  16. Content type: Letter to the Editor

    High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has nev...

    Authors: Zeina Akiki, Miora Andrianjafimasy, Farid Zerimech, Nicole Le Moual, Valérie Siroux, Orianne Dumas, Régis Matran and Rachel Nadif

    Citation: Respiratory Research 2019 20:203

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  17. Content type: Research

    Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death in the world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate cancer pr...

    Authors: Shengjie Chen, Tianyi Gu, Ziwen Lu, Lipeng Qiu, Guoliang Xiao, Xiaozhong Zhu, Feng Li, Hui Yu, Gang Li and Hanqing Liu

    Citation: Respiratory Research 2019 20:202

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  18. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for CO...

    Authors: Xiaobo Liang, Xiang He, Yin Li, Junyi Wang, Dehong Wu, Xiefang Yuan, Xiaoyun Wang and Guoping Li

    Citation: Respiratory Research 2019 20:201

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  19. Content type: Letter to the Editor

    Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronc...

    Authors: Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers and Estelle Cormet-Boyaka

    Citation: Respiratory Research 2019 20:200

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  20. Content type: Research

    Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was develo...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Saher Burhan Shaker, Jesper Rømhild Davidsen, Janelle Yorke, Ole Hilberg and Elisabeth Bendstrup

    Citation: Respiratory Research 2019 20:199

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  21. Content type: Research

    There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations ...

    Authors: Cecilia Mouronte-Roibás, Virginia Leiro-Fernández, Alberto Ruano-Raviña, Cristina Ramos-Hernández, Pedro Casado-Rey, Maribel Botana-Rial, Esmeralda García-Rodríguez and Alberto Fernández-Villar

    Citation: Respiratory Research 2019 20:198

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  22. Content type: Research

    Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness i...

    Authors: David I. Kasahara, Jeremy E. Wilkinson, Youngji Cho, Aline P. Cardoso, Curtis Huttenhower and Stephanie A. Shore

    Citation: Respiratory Research 2019 20:197

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  23. Content type: Research

    The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

    Authors: Guoqing Wang, Howard H. Lou, Jacqueline Salit, Philip L. Leopold, Sharon Driscoll, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:196

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  24. Content type: Research

    Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

    Authors: Steven J. Pascoe, Alberto Papi, Dawn Midwinter, Sally Lettis and Neil Barnes

    Citation: Respiratory Research 2019 20:195

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  25. Content type: Research

    The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

    Authors: Zhongwei Wen, Rongfang Jiang, Ying Huang, Zhineng Wen, Dong Rui, Xiaoxiao Liao and Zhougui Ling

    Citation: Respiratory Research 2019 20:194

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  26. Content type: Research

    It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...

    Authors: Young-Jin Choi, Ju-Hee Jeon and Jae-Won Oh

    Citation: Respiratory Research 2019 20:193

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  27. Content type: Research

    Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual an...

    Authors: Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin and Sheng-xing Zheng

    Citation: Respiratory Research 2019 20:192

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  28. Content type: Letter to the Editor

    Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this...

    Authors: Maeva Zysman, Pierre-Régis Burgel, Isabelle Court-Fortune, Graziella Brinchault-Rabin, Pascale Nesme-Meyer, Pascale Surpas, Gaetan Deslée, Thierry Perez, Olivier Le Rouzic, Gilles Jebrak, Pascal Chanez, Jean-Louis Paillasseur, Denis Caillaud and Nicolas Roche

    Citation: Respiratory Research 2019 20:191

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  29. Content type: Research

    Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response pl...

    Authors: Venkataramana K. Sidhaye, Janet T. Holbrook, Alyce Burke, Kuladeep R. Sudini, Sanjay Sethi, Gerard J. Criner, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Rajesh Thimmulappa, Robert A. Wise and Shyam Biswal

    Citation: Respiratory Research 2019 20:190

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  30. Content type: Research

    The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be info...

    Authors: Nicolas Roche, Anestis Antoniadis, David Hess, Pei Zhi Li, Eric Kelkel, Sylvie Leroy, Christophe Pison, Pierre-Régis Burgel and Bernard Aguilaniu

    Citation: Respiratory Research 2019 20:189

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  31. Content type: Research

    Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial d...

    Authors: Haili Sun, Fang Fang, Kun Li, Huina Zhang, Ming Zhang, Lichuan Zhang, Juan Li, Yanwen Qin and Yongxiang Wei

    Citation: Respiratory Research 2019 20:188

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  32. Content type: Research

    Acute pulmonary embolism (APE) is one of the leading causes of death in cardiovascular disease. The 30-day mortality can still be 1.7–15% in non-high-risk APE patients. Some non-high-risk patients can progress...

    Authors: Dong Jia, Xue-lian Li, Qin Zhang, Gang Hou, Xiao-ming Zhou and Jian Kang

    Citation: Respiratory Research 2019 20:187

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  33. Content type: Research

    An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...

    Authors: Stefan Andreas, Christian Röver, Judith Heinz, Sebastian Straube, Henrik Watz and Tim Friede

    Citation: Respiratory Research 2019 20:186

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  34. Content type: Research

    We previously reported cryobiopsy (Cryo) with endobronchial ultrasonography-guide sheath (EBUS-GS) for peripheral pulmonary lesions (PPLs) provides significantly larger tissues than transbronchial biopsy (TBB)...

    Authors: Ken Arimura, Mitsuko Kondo, Yoji Nagashima, Masato Kanzaki, Fumi Kobayashi, Kiyoshi Takeyama, Jun Tamaoki and Etsuko Tagaya

    Citation: Respiratory Research 2019 20:185

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  35. Content type: Research

    Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for seve...

    Authors: K. D. Hebert, N. Mclaughlin, Zhe Zhang, A. Cipriani, J. F. Alcorn and D. A. Pociask

    Citation: Respiratory Research 2019 20:184

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  36. Content type: Commentary

    Asthma is a heterogeneous lung disease, usually characterised by chronic airway inflammation. Although evidence-based treatments are available in most countries, asthma control remains suboptimal, and asthma-r...

    Authors: Jaya Muneswarao, Mohamed Azmi Hassali, Baharudin Ibrahim, Bandana Saini, Irfhan Ali Hyder Ali and Ashutosh Kumar Verma

    Citation: Respiratory Research 2019 20:183

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  37. Content type: Letter to the Editor

    Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study p...

    Authors: Spyros A. Papiris, Panagiotis Tsirigotis, Caroline Kannengiesser, Lykourgos Kolilekas, Konstantinos Gkirkas, Andriana I. Papaioannou, Patrick Revy, Paschalina Giouleka, Georgia Papadaki, Konstantinos Kagouridis, Vassiliki Pappa, Raphael Borie, Catherine Boileau, Demosthenes Bouros, Bruno Crestani and Effrosyni D. Manali

    Citation: Respiratory Research 2019 20:182

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  38. Content type: Research

    KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

    Authors: Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat, Sarah L. O’Beirne, Robert J. Kaner, Jason G. Mezey, Haijun Zhang, Philip L. Leopold and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:181

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  39. Content type: Research

    CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmon...

    Authors: Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni and Marie Anna Nandeuil

    Citation: Respiratory Research 2019 20:180

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  40. Content type: Research

    Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, ...

    Authors: Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller and Hui Cao

    Citation: Respiratory Research 2019 20:178

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  41. Content type: Research

    Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesio...

    Authors: Kyu Min Lee, Geewon Lee, Ahreum Kim, Jeongha Mok, Ji Won Lee, Yeon Joo Jeong, Eun-Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee and Jung Seop Eom

    Citation: Respiratory Research 2019 20:177

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  42. Content type: Research

    Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obs...

    Authors: Hiroto Takiguchi, Virginia Chen, Ma’en Obeidat, Zsuzsanna Hollander, J. Mark FitzGerald, Bruce M. McManus, Raymond T. Ng and Don D. Sin

    Citation: Respiratory Research 2019 20:176

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  43. Content type: Research

    The amount of surfactant deposited in the lungs and its overall pulmonary distribution determine the therapeutic outcome of surfactant replacement therapy. Most of the currently available methods to determine ...

    Authors: Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Francesca Ricci, Francesca Boscaro, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Federico Bianco, Fabrizio Salomone, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp and Alan H. Jobe

    Citation: Respiratory Research 2019 20:175

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  44. Content type: Research

    Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

    Authors: Xu Liu, Mei Mei, Xiang Chen, Yulan Lu, Xinran Dong, Liyuan Hu, Xiaojing Hu, Guoqiang Cheng, Yun Cao, Lin Yang and Wenhao Zhou

    Citation: Respiratory Research 2019 20:174

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  45. Content type: Commentary

    Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

    Authors: David A. Leather, Louisa Yates, Henrik Svedsater, Loretta Jacques, Susan Collier, Danielle Powell and Rupert Jones

    Citation: Respiratory Research 2019 20:173

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  46. Content type: Research

    Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

    Authors: Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall and Ian Sayers

    Citation: Respiratory Research 2019 20:172

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  47. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

    Authors: Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro and Mona Bafadhel

    Citation: Respiratory Research 2019 20:170

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  48. Content type: Research

    We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

    Authors: Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey and Namhee Kwon

    Citation: Respiratory Research 2019 20:169

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