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  1. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition in which an important extra-pulmonary manifestation is cardiovascular disease. We hypothesized that COPD patients would have inc...

    Authors: Marie Fisk, Joseph Cheriyan, Divya Mohan, Carmel M. McEniery, Julia Forman, John R. Cockcroft, James H. F. Rudd, Ruth Tal-Singer, Nicholas S. Hopkinson, Michael I. Polkey and Ian B. Wilkinson

    Citation: Respiratory Research 2018 19:100

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  2. Content type: Research

    Asthma is a chronic respiratory condition, with airway hyperresponsiveness (AHR) and inflammation as hallmarks. The hypothesis that the substantially increased expression of arginase 1 in activated macrophages...

    Authors: Roy H. E. Cloots, Matthew E. Poynter, Els Terwindt, Wouter H. Lamers and S. Eleonore Köhler

    Citation: Respiratory Research 2018 19:98

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  3. Content type: Research

    Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function declin...

    Authors: Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang and Ji Ye Jung

    Citation: Respiratory Research 2018 19:99

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  4. Content type: Research

    The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP...

    Authors: Nina S. Godtfredsen, Ditte V. Jørgensen, Kristoffer Marsaa, Charlotte S. Ulrik, Ove Andersen, Jesper Eugen-Olsen and Line J. H. Rasmussen

    Citation: Respiratory Research 2018 19:97

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  5. Content type: Research

    Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking o...

    Authors: Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He and Ping Yang

    Citation: Respiratory Research 2018 19:94

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  6. Content type: Research

    Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently,...

    Authors: Stephanie Everaerts, Elise J. Lammertyn, Dries S. Martens, Laurens J. De Sadeleer, Karen Maes, Aernoud A. van Batenburg, Roel Goldschmeding, Coline H. M. van Moorsel, Lieven J. Dupont, Wim A. Wuyts, Robin Vos, Ghislaine Gayan-Ramirez, Naftali Kaminski, James C. Hogg, Wim Janssens, Geert M. Verleden…

    Citation: Respiratory Research 2018 19:95

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  7. Content type: Research

    Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affe...

    Authors: P. Heukels, J. A. C. van Hulst, M. van Nimwegen, C. E. Boorsma, B. N. Melgert, L. M. van den Toorn, K. A. T. Boomars, M. S. Wijsenbeek, H. Hoogsteden, J. H. von der Thüsen, R. W. Hendriks, M. Kool and B. van den Blink

    Citation: Respiratory Research 2018 19:90

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  8. Content type: Research

    Intrauterine infection/inflammation plays an important role in the development of lung injury and bronchopulmonary dysplasia (BPD) in preterm infants, While a multifactorial genesis is likely, mechanisms invol...

    Authors: Jiarong Pan, Canyang Zhan, Tianming Yuan, Weiyan Wang, Ying Shen, Yi Sun, Tai Wu, Weizhong Gu, Lihua Chen and Huimin Yu

    Citation: Respiratory Research 2018 19:93

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  9. Content type: Research

    Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of huma...

    Authors: Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson and Jeffrey C. Horowitz

    Citation: Respiratory Research 2018 19:91

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  10. Content type: Research

    Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especi...

    Authors: Maria G. Belvisi, Katie Baker, Nicole Malloy, Kristof Raemdonck, Bilel Dekkak, Michael Pieper, Anthony T. Nials and Mark A. Birrell

    Citation: Respiratory Research 2018 19:89

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  11. Content type: Research

    Cardiovascular disease are common co-morbidities in bronchiectasis and contribute substantially to disease burden and mortality. Brachial-ankle pulse wave velocity (baPWV), a measure of arterial stiffness, has...

    Authors: Yong-hua Gao, Juan-juan Cui, Ling-yun Wang, Ke-qin Yin, Li Wang, Guo-jun Zhang and Shao-xia Liu

    Citation: Respiratory Research 2018 19:86

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  12. Content type: Research

    COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the ...

    Authors: Mark M. Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J. Halayko, Ian Adcock and Kian Fan Chung

    Citation: Respiratory Research 2018 19:85

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  13. Content type: Research

    Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder associated with high pulmonary artery pressure. Genetic testing enables early diagnosis and offers an opportunity for family screening....

    Authors: Hang Yang, Qixian Zeng, Yanyun Ma, Bingyang Liu, Qianlong Chen, Wenke Li, Changming Xiong and Zhou Zhou

    Citation: Respiratory Research 2018 19:87

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  14. Content type: Research

    The REVOLENS study compared lung volume reduction coil treatment to usual care in patients with severe emphysema at 1 year, resulting in improved quality-adjusted life-year (QALY) and higher costs. Durability ...

    Authors: Julie Bulsei, Sylvie Leroy, Jeanne-Marie Perotin, Hervé Mal, Charles-Hugo Marquette, Hervé Dutau, Arnaud Bourdin, Jean-Michel Vergnon, Christophe Pison, Romain Kessler, Vincent Jounieaux, Mathieu Salaün, Armelle Marceau, Sylvain Dukic, Coralie Barbe, Margaux Bonnaire…

    Citation: Respiratory Research 2018 19:84

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  15. Content type: Research

    Preclinical data suggest that oncogene (EGFR and KRAS) events regulate tumor procoagulant activity. However, few studies have prospectively investigated the clinical relevance between the presence of EGFR or K...

    Authors: Feifei Dou, Huiqiao Li, Min Zhu, Lirong Liang, Yuan Zhang, Jiawen Yi and Yuhui Zhang

    Citation: Respiratory Research 2018 19:88

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  16. Content type: Research

    Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm characterized by the pulmonary infiltration of smooth muscle-like cells (LAM cells) and cystic destruction. Patients usually present with airway obstructi...

    Authors: Ellen Caroline Toledo do Nascimento, Bruno Guedes Baldi, Alessandro Wasum Mariani, Raquel Annoni, Ronaldo Adib Kairalla, Suzana Pinheiro Pimenta, Luiz Fernando Ferraz da Silva, Carlos Roberto Ribeiro Carvalho and Marisa Dolhnikoff

    Citation: Respiratory Research 2018 19:83

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  17. Content type: Research

    Pneumonia is responsible for approximately 230,000 deaths in Europe, annually. Comprehensive and comparable reports on pneumonia mortality trends across the European Union (EU) are lacking.

    Authors: Dominic C. Marshall, Ross J. Goodson, Yiwang Xu, Matthieu Komorowski, Joseph Shalhoub, Mahiben Maruthappu and Justin D. Salciccioli

    Citation: Respiratory Research 2018 19:81

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  18. Content type: Research

    Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease a...

    Authors: Jannie M. B. Sand, Yoshinori Tanino, Morten A. Karsdal, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Xintao Wang, Diana J. Leeming and Mitsuru Munakata

    Citation: Respiratory Research 2018 19:82

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  19. Content type: Research

    Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implic...

    Authors: Judith J. M. Ceelen, Annemie M. W. J. Schols, Nathalie G. M. Thielen, Astrid Haegens, Douglas A. Gray, Marco C. J. M. Kelders, Chiel C. de Theije and Ramon C. J. Langen

    Citation: Respiratory Research 2018 19:80

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  20. Content type: Correction

    In the original publication [1] is an error in table 1. The correct version can be found in this Erratum:

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael O. Silva

    Citation: Respiratory Research 2018 19:77

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    The original article was published in Respiratory Research 2018 19:13

  21. Content type: Research

    In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify...

    Authors: Alison G. Lee, Blake Le Grand, Hsiao-Hsien Leon Hsu, Yueh-Hsiu Mathilda Chiu, Kasey J. Brennan, Sonali Bose, Maria José Rosa, Kelly J. Brunst, Itai Kloog, Ander Wilson, Joel Schwartz, Wayne Morgan, Brent A. Coull, Robert O. Wright, Andrea A. Baccarelli and Rosalind J. Wright

    Citation: Respiratory Research 2018 19:76

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