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  1. Research

    24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD

    Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover stu...

    Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose and Ubaldo Martin

    Respiratory Research 2017 18:157

    Published on: 18 August 2017

  2. Review

    Regulation of human airway smooth muscle cell migration and relevance to asthma

    Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the ...

    Brittany Salter, Cara Pray, Katherine Radford, James G. Martin and Parameswaran Nair

    Respiratory Research 2017 18:156

    Published on: 16 August 2017

  3. Review

    Role and regulation of MKP-1 in airway inflammation

    Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over...

    Seyed M. Moosavi, Pavan Prabhala and Alaina J. Ammit

    Respiratory Research 2017 18:154

    Published on: 10 August 2017

  4. Research

    Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

    Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice...

    Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf and Koustav Ganguly

    Respiratory Research 2017 18:152

    Published on: 9 August 2017

  5. Research

    A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease

    Interleukin-1 receptor 1 (IL-1R1) inhibition is a potential strategy for treating patients with chronic obstructive pulmonary disease (COPD). MEDI8968, a fully human monoclonal antibody, binds selectively to I...

    Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold and René van der Merwe

    Respiratory Research 2017 18:153

    Published on: 9 August 2017

  6. Research

    Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation

    Alveolar type 2 (AT2) cells play important roles in maintaining adult lung homeostasis. AT2 cells isolated from the lung have revealed the cell-specific functions of AT2 cells. Comprehensive molecular and tran...

    Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro and Toyohiro Hirai

    Respiratory Research 2017 18:150

    Published on: 7 August 2017

  7. Review

    Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers

    The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after l...

    Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson and Lars C. Huber

    Respiratory Research 2017 18:151

    Published on: 7 August 2017

  8. Research

    Airway and parenchyma immune cells in influenza A(H1N1)pdm09 viral and non-viral diffuse alveolar damage

    Diffuse alveolar damage (DAD), which is the histological surrogate for acute respiratory distress syndrome (ARDS), has a multifactorial aetiology. Therefore it is possible that the immunopathology differs amon...

    Monique Buttignol, Ruy Camargo Pires-Neto, Renata Calciolari Rossi e Silva, Marina Ballarin Albino, Marisa Dolhnikoff and Thais Mauad

    Respiratory Research 2017 18:147

    Published on: 3 August 2017

  9. Review

    Using omics approaches to understand pulmonary diseases

    Omics approaches are high-throughput unbiased technologies that provide snapshots of various aspects of biological systems and include: 1) genomics, the measure of DNA variation; 2) transcriptomics, the measur...

    Mengyuan Kan, Maya Shumyatcher and Blanca E. Himes

    Respiratory Research 2017 18:149

    Published on: 3 August 2017

  10. Letter to the Editor

    Small airway bronchodilator response to different doses of salbutamol in 7-year-old children

    The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the osc...

    Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee and Man Yong Han

    Respiratory Research 2017 18:148

    Published on: 3 August 2017

  11. Research

    The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study

    Methacholine dose-response curves illustrate pharmacologic bronchoprotection against methacholine-induced airway hyperresponsiveness and can be used to quantitate changes in airway sensitivity (position), reac...

    Christianne M. Blais, Beth E. Davis and Donald W. Cockcroft

    Respiratory Research 2017 18:146

    Published on: 2 August 2017

  12. Research

    The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis

    Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respi...

    T. B. M. Tilanus, J. T. Groothuis, J. M. C. TenBroek-Pastoor, T. B. Feuth, Y. F. Heijdra, J. P. L. Slenders, J. Doorduin, B. G. Van Engelen, M. J. Kampelmacher and J. Raaphorst

    Respiratory Research 2017 18:144

    Published on: 25 July 2017

  13. Research

    Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure

    Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based on a-priori knowledg...

    K. de Jong, J.M. Vonk, M. Imboden, L. Lahousse, A. Hofman, G.G. Brusselle, N.M. Probst-Hensch, D.S. Postma and H.M. Boezen

    Respiratory Research 2017 18:142

    Published on: 24 July 2017

  14. Research

    Efficacy and safety of direct switch to indacaterol/glycopyrronium in patients with moderate COPD: the CRYSTAL open-label randomised trial

    Dual bronchodilation combining a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by the Global Initiative for Chronic Obstructive Lung...

    Claus F. Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M. Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens and Konstantinos Kostikas

    Respiratory Research 2017 18:140

    Published on: 18 July 2017

  15. Research

    Fibrocyte measurement in peripheral blood correlates with number of cultured mature fibrocytes in vitro and is a potential biomarker for interstitial lung disease in Rheumatoid Arthritis

    Interstitial lung disease (ILD) can be a severe extra-articular disease manifestation in Rheumatoid Arthritis (RA). A potential role of fibrocytes in RA associated ILD (RA-ILD) has not previously been describe...

    Søren Andreas Just, Hanne Lindegaard, Eva Kildall Hejbøl, Jesper Rømhild Davidsen, Niels Bjerring, Søren Werner Karlskov Hansen, Henrik Daa Schrøder, Inger Marie Jensen Hansen, Torben Barington and Christian Nielsen

    Respiratory Research 2017 18:141

    Published on: 18 July 2017

  16. Research

    Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

    The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary ...

    Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner…

    Respiratory Research 2017 18:139

    Published on: 14 July 2017

  17. Research

    Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

    Mesenchymal stem cells (MSCs) attenuate lung injury in experimental models of bronchopulmonary dysplasia (BPD). Stromal derived factor-1 (SDF-1), a chemokine secreted by MSCs, modulates angiogenesis and stem c...

    Joel Reiter, Shelley Drummond, Ibrahim Sammour, Jian Huang, Victoria Florea, Polliana Dornas, Joshua M. Hare, Claudia O. Rodrigues and Karen C. Young

    Respiratory Research 2017 18:137

    Published on: 12 July 2017

  18. Research

    Which early life events or current environmental and lifestyle factors influence lung function in adolescents? – results from the GINIplus & LISAplus studies

    Various factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current envi...

    Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak and Holger Schulz

    Respiratory Research 2017 18:138

    Published on: 12 July 2017

  19. Research

    Sirolimus alters lung pathology and viral load following influenza A virus infection

    Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lun...

    Ahmed R. Alsuwaidi, Junu A. George, Saeeda Almarzooqi, Stacey M. Hartwig, Steven M. Varga and Abdul-Kader Souid

    Respiratory Research 2017 18:136

    Published on: 11 July 2017

  20. Research

    Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects

    Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstr...

    Matthieu Hein, Jean-Pol Lanquart, Gwénolé Loas, Philippe Hubain and Paul Linkowski

    Respiratory Research 2017 18:135

    Published on: 6 July 2017

  21. Research

    Bronchial thermoplasty: activations predict response

    Bronchial thermoplasty (BT) is an emerging bronchoscopic intervention for the treatment of severe asthma. The predictive factors for clinical response to BT are unknown. We examined the relationship between th...

    David Langton, Joy Sha, Alvin Ing, David Fielding, Francis Thien and Virginia Plummer

    Respiratory Research 2017 18:134

    Published on: 4 July 2017

  22. Letter to the Editor

    Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?

    The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of inflammat...

    Sophie F. Demarche, Florence N. Schleich, Virginie A. Paulus, Monique A. Henket, Thierry J. Van Hees and Renaud E. Louis

    Respiratory Research 2017 18:133

    Published on: 3 July 2017

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