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  1. Content type: Research

    Endothelial barrier dysfunction is central to the pathogenesis of sepsis-associated acute lung injury (ALI). Microtubule (MT) dynamics in vascular endothelium are crucial for the regulation of endothelial barr...

    Authors: Shengtian Mu, Yina Liu, Jing Jiang, Renyu Ding, Xu Li, Xin Li and Xiaochun Ma

    Citation: Respiratory Research 2018 19:220

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  2. Content type: Research

    Pulmonary complications are common in primary immunodeficiency diseases (PID) and contribute to morbidity and mortality in these patients. However, their varied presentation and a general lack of awareness of ...

    Authors: Pere Soler-Palacín, Javier de Gracia, Luis Ignacio González-Granado, Carlos Martín, Carlos Rodríguez-Gallego, Silvia Sánchez-Ramón and Lung ID-Signal Group

    Citation: Respiratory Research 2018 19:219

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  3. Content type: Review

    Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells. Their therapeutic potential appears promising as evide...

    Authors: Arezoo Mohammadipoor, Ben Antebi, Andriy I. Batchinsky and Leopoldo C. Cancio

    Citation: Respiratory Research 2018 19:218

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  4. Content type: Review

    Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists are novel agents for asthma but with controversial efficacies in clinical trials. Therefore, we conducted a meta-analysis...

    Authors: Jing Yang, Jian Luo, Ling Yang, Dan Yang, Dan Wang, Bicui Liu, Tingxuan Huang, Xiaohu Wang, Binmiao Liang and Chuntao Liu

    Citation: Respiratory Research 2018 19:217

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  5. Content type: Research

    The soluble receptor for advanced glycation end-products (sRAGE) has been suggested that it acts as a decoy for capturing advanced glycation end-products (AGEs) and inhibits the activation of the oxidative str...

    Authors: Carlos Machahua, Ana Montes-Worboys, Lurdes Planas-Cerezales, Raquel Buendia-Flores, Maria Molina-Molina and Vanesa Vicens-Zygmunt

    Citation: Respiratory Research 2018 19:215

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  6. Content type: Research

    The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH).

    Authors: Lukas Fischer, Nicola Benjamin, Norbert Blank, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Maria Koegler, Hanns-Martin Lorenz, Alberto M. Marra, Christian Nagel, Panagiota Xanthouli, Eduardo Bossone and Ekkehard Grünig

    Citation: Respiratory Research 2018 19:216

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  7. Content type: Research

    The potential effects of pulmonary dysfunction on cardiovascular diseases (CVD) are receiving attention. We aimed to investigate and quantify the cross-sectional and longitudinal associations between lung func...

    Authors: Bin Wang, Yun Zhou, Lili Xiao, Yanjun Guo, Jixuan Ma, Min Zhou, Tingming Shi, Aijun Tan, Jing Yuan and Weihong Chen

    Citation: Respiratory Research 2018 19:214

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  8. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim...

    Authors: J. Clukers, M. Lanclus, B. Mignot, C. Van Holsbeke, J. Roseman, S. Porter, E. Gorina, E. Kouchakji, K. E. Lipson, W. De Backer and J. De Backer

    Citation: Respiratory Research 2018 19:213

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  9. Content type: Research

    The obesity paradox in COPD describes protective effects of obesity on lung pathology and inflammation. However, the underlying relationships between obesity, diet and disease outcomes in COPD are not fully un...

    Authors: Sandra Rutting, Michael Papanicolaou, Dia Xenaki, Lisa G. Wood, Alexander M. Mullin, Philip M. Hansbro and Brian G. Oliver

    Citation: Respiratory Research 2018 19:211

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  10. Content type: Research

    Genetic and environmental factors play a role in the development of COPD. The epigenome, and more specifically DNA methylation, is recognized as important link between these factors. We postulate that DNA meth...

    Authors: Maaike de Vries, Diana A van der Plaat, Ivana Nedeljkovic, Rikst Nynke Verkaik-Schakel, Wierd Kooistra, Najaf Amin, Cornelia M van Duijn, Corry-Anke Brandsma, Cleo C van Diemen, Judith M Vonk and H Marike Boezen

    Citation: Respiratory Research 2018 19:212

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  11. Content type: Research

    Aspirin-exacerbated respiratory disease (AERD) is a distinct eosinophilic phenotype of severe asthma with accompanying chronic rhinosinusitis, nasal polyposis, and hypersensitivity to aspirin. Urinary 3-bromot...

    Authors: Suzy A. A. Comhair, Grazyna Bochenek, Sara Baicker-McKee, Zeneng Wang, Tomasz Stachura, Marek Sanak, Jeffrey P. Hammel, Stanley L. Hazen, Serpil C. Erzurum and Ewa Nizankowska-Mogilnicka

    Citation: Respiratory Research 2018 19:210

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  12. Content type: Review

    Rhinovirus (RV) exposure has been implicated in childhood development of wheeze evoking asthma and exacerbations of underlying airways disease. Studies such as the Copenhagen Prospective Studies on Asthma in C...

    Authors: Dennis Lo, Joshua L. Kennedy, Richard C. Kurten, Reynold A. Panettieri Jr and Cynthia J. Koziol-White

    Citation: Respiratory Research 2018 19:208

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  13. Content type: Research

    Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood as...

    Authors: Lystra P. Hayden, Michael H. Cho, Benjamin A. Raby, Terri H. Beaty, Edwin K. Silverman and Craig P. Hersh

    Citation: Respiratory Research 2018 19:209

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  14. Content type: Research

    The microenvironment (ME) of neuroepithelial bodies (NEBs) harbors densely innervated groups of pulmonary neuroendocrine cells that are covered by Clara-like cells (CLCs) and is believed to be important during...

    Authors: Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns and Dirk Adriaensen

    Citation: Respiratory Research 2018 19:207

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  15. Content type: Research

    The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration. FBXO17 was recently identified as...

    Authors: Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli and Yutong Zhao

    Citation: Respiratory Research 2018 19:206

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  16. Content type: Research

    Pneumonia is a relevant clinical and public health issue worldwide frequently associated with infections caused by Multi-Drug Resistant (MDR) pathogens. Ceftaroline fosamil is a promising new antibiotics with ...

    Authors: Giovanni Sotgiu, Stefano Aliberti, Andrea Gramegna, Marco Mantero, Marta Di Pasquale, Federica Trogu, Laura Saderi and Francesco Blasi

    Citation: Respiratory Research 2018 19:205

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  17. Content type: Letter to the editor

    Type II alveolar epithelial cells (AT2) play a pivotal role in maintaining the integrity and function of the alveoli. Only recently, the role of impaired epithelial repair mechanisms after injury in the pathog...

    Authors: Petra Khan, Kleanthis Fytianos, Luca Tamò, Michael Roth, Michael Tamm, Thomas Geiser, Amiq Gazdhar and Katrin E Hostettler

    Citation: Respiratory Research 2018 19:204

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  18. Content type: Review

    High-flow nasal cannula (HFNC) can be used as an initial support strategy for patients with acute respiratory failure (ARF) and after extubation. However, no clear evidence exists to support or oppose HFNC use...

    Authors: Zhiheng Xu, Yimin Li, Jianmeng Zhou, Xi Li, Yongbo Huang, Xiaoqing Liu, Karen E. A. Burns, Nanshan Zhong and Haibo Zhang

    Citation: Respiratory Research 2018 19:202

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  19. Content type: Research

    The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact...

    Authors: Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai and Fei Xiao

    Citation: Respiratory Research 2018 19:201

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  20. Content type: Research

    Pulmonary arterial smooth muscle cell (PASMC) proliferation in response to hypoxia plays an important role in the vascular remodelling that occurs in hypoxic pulmonary hypertension. MicroRNAs (miRs) are emergi...

    Authors: Guangjie Liu, Peng Hao, Jie Xu, Liming Wang, Yuchuan Wang, Ruifang Han, Ming Ying, Shuangshuang Sui, Jinghua Liu and Xuan Li

    Citation: Respiratory Research 2018 19:200

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  21. Content type: Research

    Although pharmacological treatment has increased the average life expectancy of patients with cystic fibrosis, the median survival of females is shorter than that of males. In vitro and in vivo studies have sh...

    Authors: Roberto Imberti, Maria Lisa Garavaglia, Ivan Verduci, Gaetano Cannavale, Giorgio Balduzzi, Sara Papetti and Michele Mazzanti

    Citation: Respiratory Research 2018 19:198

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  22. Content type: Research

    Use of inhaled corticosteroids (ICS) increases the risk of pneumonia in chronic obstructive pulmonary disease (COPD), but the magnitude of risk with different ICS remains unclear.

    Authors: Donald P. Tashkin, Marc Miravitlles, Bartolomé R. Celli, Norbert Metzdorf, Achim Mueller, David M. G. Halpin and Antonio Anzueto

    Citation: Respiratory Research 2018 19:196

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  23. Content type: Research

    Potential relationship between serum soluble programmed cell death ligand 1 and prognosis of small cell lung cancer is not well explored. The aim of the study was to reveal the prognostic significance of serum...

    Authors: Jianjun Jin, Jiming Si, Yuanhua Liu, Huanqin Wang, Ran Ni and Jing Wang

    Citation: Respiratory Research 2018 19:197

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  24. Content type: Research

    Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other in...

    Authors: Joo Heung Yoon, Mehdi Nouraie, Xiaoping Chen, Richard H Zou, Jacobo Sellares, Kristen L Veraldi, Jared Chiarchiaro, Kathleen Lindell, David O Wilson, Naftali Kaminski, Timothy Burns, Humberto Trejo Bittar, Samuel Yousem, Kevin Gibson and Daniel J Kass

    Citation: Respiratory Research 2018 19:195

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  25. Content type: Research

    Obstructive sleep apnea-hypopnea syndrome (OSAHS) is prone to being complicated with various cardiovascular, cerebrovascular and metabolic conditions. OSAHS, due to its multifactorial nature, entails individua...

    Authors: Xiuping Yang, Xun Niu, Ying Xiao, Kun Lin and Xiong Chen

    Citation: Respiratory Research 2018 19:194

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  26. Content type: Research

    Cough pressure, an expression of expiratory muscle strength, is usually measured with esophageal or gastric balloons, but these invasive catheters can be uncomfortable for the patient or their placement imprac...

    Authors: Lluís G. Aguilera, Lluís Gallart, Juan C. Álvarez, Jordi Vallès and Joaquim Gea

    Citation: Respiratory Research 2018 19:191

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  27. Content type: Review

    Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, ...

    Authors: Christian Domingo, Oscar Palomares, David A. Sandham, Veit J. Erpenbeck and Pablo Altman

    Citation: Respiratory Research 2018 19:189

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  28. Content type: Research

    Pneumonia is a major cause of high morbidity and mortality in critically illness, and frequently requires support with mechanical ventilation. The latter can lead to ventilator-induced lung injury characterize...

    Authors: Junbo Zheng, Yongbo Huang, Diana Islam, Xiao-Yan Wen, Sulong Wu, Catherine Streutker, Alice Luo, Manshu Li, Julie Khang, Bing Han, Nanshan Zhong, Yimin Li, Kaijiang Yu and Haibo Zhang

    Citation: Respiratory Research 2018 19:190

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  29. Content type: Research

    Fibrosis in severe asthma often leads to irreversible organ dysfunction. However, the mechanism that regulates fibrosis remains poorly understood. Interleukin (IL)-32 plays a role in several chronic inflammato...

    Authors: Gyong Hwa Hong, So-Young Park, Hyouk-Soo Kwon, Bo-Ram Bang, Jaechun Lee, Sang-Yeob Kim, Chan-Gi Pack, Soohyun Kim, Keun-Ai Moon, Tae-Bum Kim, Hee-Bom Moon and You Sook Cho

    Citation: Respiratory Research 2018 19:188

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  30. Content type: Research

    Streptococcus pneumoniae is a respiratory pathogen causing severe lung infection that may lead to complications such as bacteremia. Current polysaccharide vaccines have limited serotype coverage and therefore can...

    Authors: Chen-Fang Hsu, Chen-Hao Hsiao, Shun-Fu Tseng, Jian-Ru Chen, Yu-Jou Liao, Sy-Jou Chen, Chin-Sheng Lin, Huey-Kang Sytwu and Yi-Ping Chuang

    Citation: Respiratory Research 2018 19:187

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  31. Content type: Research

    Systemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a common and early complication, being the l...

    Authors: Amelia Chiara Trombetta, Stefano Soldano, Paola Contini, Veronica Tomatis, Barbara Ruaro, Sabrina Paolino, Renata Brizzolara, Paola Montagna, Alberto Sulli, Carmen Pizzorni, Vanessa Smith and Maurizio Cutolo

    Citation: Respiratory Research 2018 19:186

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  32. Content type: Research

    Preserved ratio impaired spirometry (PRISm) is an incompletely understood respiratory condition. We investigated the incidence and significant predictive factors of chronic obstructive pulmonary disease (COPD)...

    Authors: Hye Jung Park, Min Kwang Byun, Chin Kook Rhee, Kyungjoo Kim, Hyung Jung Kim and Kwang-Ha Yoo

    Citation: Respiratory Research 2018 19:185

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  33. Content type: Research

    HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of HIV on asthma prevalence in high HIV burden settings. The objective of this analysis was to compare the preval...

    Authors: Bruce J. Kirenga, Levicatus Mugenyi, Corina de Jong, J. Lucian Davis, Winceslaus Katagira, Thys van der Molen, Moses R. Kamya and Marike Boezen

    Citation: Respiratory Research 2018 19:184

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  34. Content type: Research

    Few data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD).

    Authors: Silvia Perez-Bogerd, Wim Wuyts, Veronica Barbier, Heleen Demeyer, Alain Van Muylem, Wim Janssens and Thierry Troosters

    Citation: Respiratory Research 2018 19:182

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  35. Content type: Review

    Chronic Obstructive Pulmonary Disease (COPD) is a common, multifactorial lung disease which results in significant impairment of patients’ health and a large impact on society and health care burden. It is bel...

    Authors: Helena Crisford, Elizabeth Sapey and Robert A. Stockley

    Citation: Respiratory Research 2018 19:180

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  36. Content type: Research

    Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural...

    Authors: Joanna C. Grogono, Clare Butler, Hooshang Izadi and Shakeeb H. Moosavi

    Citation: Respiratory Research 2018 19:181

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  37. Content type: Research

    Fibroblast growth factor 23 (FGF23) regulates phosphate metabolism by increasing renal phosphate excretion and decreasing 1.25-dihydroxyvitamin D synthesis. Reports about hypophosphatemia in patients with chro...

    Authors: Alexandra Stroda, Vincent Brandenburg, Ayham Daher, Christian Cornelissen, Claudia Goettsch, András Keszei and Michael Dreher

    Citation: Respiratory Research 2018 19:183

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  38. Content type: Research

    Epidemiologic studies have demonstrated associations between acetaminophen use and asthma. This investigation sought to determine whether sex modifies the acetaminophen-asthma association and whether leptin (LEP)...

    Authors: Ali H. Ziyab, Nandini Mukherjee, Ramesh J. Kurukulaaratchy, Hongmei Zhang, Susan Ewart, Hasan Arshad and Wilfried Karmaus

    Citation: Respiratory Research 2018 19:179

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  39. Content type: Research

    Classification of COPD is usually based on the severity of airflow, which may not sensitively differentiate subpopulations. Using a multiscale imaging-based cluster analysis (MICA), we aim to identify subpopul...

    Authors: Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup, Fernando J. Martinez…

    Citation: Respiratory Research 2018 19:178

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  40. Content type: Letter to the Editor

    There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled cortico...

    Authors: K. O. Tonga, G. G. King, C. S. Farah, C. Thamrin, F. S. Tang, J. Santos, P. Sharma, D. G. Chapman and B. G. Oliver

    Citation: Respiratory Research 2018 19:176

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  41. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to f...

    Authors: Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner and Melanie Königshoff

    Citation: Respiratory Research 2018 19:175

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  42. Content type: Research

    Berardinelli-Seip Congenital Generalized Lipodystrophy (BSCL) is an ultra-rare metabolic disease characterized by hypertriglyceridemia, hyperinsulinemia, hyperglycemia, hypoleptinemia, and diabetes mellitus. A...

    Authors: Jorge Luiz Dantas de Medeiros, Bruno Carneiro Bezerra, Thiago Anderson Brito de Araújo, Aquiles Sales Craveiro Sarmento, Lázaro Batista de Azevedo Medeiros, Lucien Peroni Gualdi, Maria do Socorro Luna Cruz, Thaiza Teixeira Xavier Nobre, Josivan Gomes Lima and Julliane Tamara Araújo de Melo Campos

    Citation: Respiratory Research 2018 19:173

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  43. Content type: Research

    Inhaled corticosteroids (ICS) are associated with an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD). Other factors such as severity of airflow limitation and concurre...

    Authors: Christer Janson, Gunnar Johansson, Björn Ställberg, Karin Lisspers, Petter Olsson, Dorothy L. Keininger, Milica Uhde, Florian S. Gutzwiller, Leif Jörgensen and Kjell Larsson

    Citation: Respiratory Research 2018 19:172

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  44. Content type: Research

    There is a need for non-invasive parameters that are sensitive to the development of the bronchiolitis obliterans syndrome (BOS) in lung transplantation (LTx) patients. We studied whether the pulmonary diffusi...

    Authors: Anna Winkler, Kathrin Kahnert, Jürgen Behr, Claus Neurohr, Nikolaus Kneidinger, Rudolf Hatz, Holger Dressel, Thomas Radtke and Rudolf A. Jörres

    Citation: Respiratory Research 2018 19:171

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