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  1. There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put forward as promising biomarker for CO...

    Authors: Frank Klont, Peter Horvatovich, Russell P. Bowler, Eva van Rikxoort, Jean-Paul Charbonnier, Marcel Kwiatkowski, David A. Lynch, Stephen Humphries, Rainer Bischoff, Nick H. T. ten Hacken and Simon D. Pouwels

    Citation: Respiratory Research 2022 23:15

    Content type: Research

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  2. Heparan sulfate (HS) degradation mediates pulmonary endothelial hyper-permeability and acute pulmonary edema during acute respiratory distress syndrome (ARDS). The aim of this study was to examine whether hist...

    Authors: Yanlin Zhang, Fei Xu, Li Guan, Ming Chen, Yiran Zhao, Lixia Guo, Xiao Li, Yimu Zheng, Ai Gao and Shuqiang Li

    Citation: Respiratory Research 2022 23:14

    Content type: Research

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  3. Non-invasive ventilation (NIV) is a recommended treatment for COPD patients suffering from chronic hypercapnic respiratory failure. Prolonged dyspnea after mask removal in the morning, often referred to as dev...

    Authors: Mareike Lüthgen, Stephan Rüller and Christian Herzmann

    Citation: Respiratory Research 2022 23:13

    Content type: Research

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  4. Fibrotic Interstitial lung diseases (ILD) are a heterogeneous group of chronic lung diseases characterized by diverse degrees of lung inflammation and remodeling. They include idiopathic ILD such as idiopathic...

    Authors: L. Plantier, A. Smolinska, R. Fijten, M. Flamant, J. Dallinga, J. J. Mercadier, D. Pachen, M. P. d’Ortho, F. J. van Schooten, B. Crestani and A. W. Boots

    Citation: Respiratory Research 2022 23:12

    Content type: Research

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  5. Airway mucus hypersecretion is one of the important pathological features of chronic obstructive pulmonary disease (COPD). MUC5B is the main mucin expressed in the airways of COPD patients and has been indicat...

    Authors: Xuan Huang, Weijie Guan, Bin Xiang, Wei Wang, Yanqing Xie and Jinping Zheng

    Citation: Respiratory Research 2022 23:11

    Content type: Research

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  6. Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease characterized by a persistent limitation in airflow. Gut microbiota is closely correlated with lung inflammation. However, gu...

    Authors: Yu-Chi Chiu, Shih-Wei Lee, Chi-Wei Liu, Tzuo-Yun Lan and Lawrence Shih-Hsin Wu

    Citation: Respiratory Research 2022 23:10

    Content type: Research

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  7. Excess pulmonary iron has been implicated in the pathogenesis of lung disease, including asthma and COPD. An association between higher iron content in sputum macrophages and infective exacerbations of COPD ha...

    Authors: Terence Ho, Matthew Nichols, Gayatri Nair, Katherine Radford, Melanie Kjarsgaard, Chynna Huang, Anurag Bhalla, Nicola Lavigne, Manali Mukherjee, Michael Surette, Joseph Macri and Parameswaran Nair

    Citation: Respiratory Research 2022 23:8

    Content type: Research

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  8. The comparison of respiratory system compliance (Crs) between COVID and non-COVID ARDS patients has been the object of debate, but few studies have evaluated it when considering applied positive end expiratory pr...

    Authors: Federica Fusina, Filippo Albani, Serena Crisci, Alessandro Morandi, Francesca Tansini, Rasula Beschi, Antonio Rosano and Giuseppe Natalini

    Citation: Respiratory Research 2022 23:7

    Content type: Research

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  9. Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced disorder pathologically characterized by pulmonary vascular remodeling. Notch4 as a cell surface receptor is critical for vascular develop...

    Authors: Mingzhou Guo, Mengzhe Zhang, Xiaopei Cao, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Jianping Zhao, Yongjian Xu, Xiansheng Liu and Xiaochen Li

    Citation: Respiratory Research 2022 23:6

    Content type: Research

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  10. Chronic obstructive pulmonary disease (COPD) is a frequently encountered disease condition in clinical practice mainly caused by cigarette smoke (CS). The aim of this study was to investigate the protective ro...

    Authors: Zhixing Zhu, Xihua Lian, Xiaoshan Su, Weijing Wu, Yiming Zeng and Xiaoyang Chen

    Citation: Respiratory Research 2022 23:5

    Content type: Research

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  11. The exact risk assessment is crucial for the management of connective tissue disease-associated interstitial lung disease (CTD-ILD) patients. In the present study, we develop a nomogram to predict 3‑ and 5-yea...

    Authors: Di Sun, Yu Wang, Qing Liu, Tingting Wang, Pengfei Li, Tianci Jiang, Lingling Dai, Liuqun Jia, Wenjing Zhao and Zhe Cheng

    Citation: Respiratory Research 2022 23:4

    Content type: Research

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  12. Performance benchmarks for the management of idiopathic pulmonary fibrosis (IPF) have not been established. We used data from the IPF-PRO Registry, an observational registry of patients with IPF managed at sit...

    Authors: Joao A. de Andrade, Tejaswini Kulkarni, Megan L. Neely, Anne S. Hellkamp, Amy Hajari Case, Daniel A. Culver, Kalpalatha Guntupalli, Shaun Bender, Craig S. Conoscenti and Laurie D. Snyder

    Citation: Respiratory Research 2022 23:3

    Content type: Research

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  13. Authors: Sevdalina Nikolova, Andreas Guenther, Rajkumar Savai, Norbert Weissmann, Hossein A. Ghofrani, Melanie Konigshoff, Oliver Eickelberg, Walter Klepetko, Robert Voswinckel, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly and Soni S. Pullamsetti

    Citation: Respiratory Research 2022 23:2

    Content type: Correction

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    The original article was published in Respiratory Research 2010 11:146

  14. Both allergen-specific IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to sys...

    Authors: Marek Lommatzsch, Timotheus Speer, Christian Herr, Rudolf A. Jörres, Henrik Watz, Achim Müller, Tobias Welte, Claus F. Vogelmeier and Robert Bals

    Citation: Respiratory Research 2022 23:1

    Content type: Research

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  15. Pulmonary fibrosis is thought to be driven by recurrent alveolar epithelial injury which leads to the differentiation of fibroblasts into α-smooth muscle actin (α-SMA)-expressing myofibroblasts and subsequent ...

    Authors: Joshua Trivlidis, Noof Aloufi, Fatmah Al-Habeeb, Parameswaran Nair, Ilan Azuelos, David H. Eidelman and Carolyn J. Baglole

    Citation: Respiratory Research 2021 22:323

    Content type: Research

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  16. Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, ...

    Authors: Hye Jin Jang, Ji Yeon Choi, Kangjoon Kim, Seung Hyun Yong, Yeon Wook Kim, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Young-Jae Cho and Sang Hoon Lee

    Citation: Respiratory Research 2021 22:322

    Content type: Research

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  17. Pulmonary hypertension (PH) is one of the common complications in chronic obstructive pulmonary disease (COPD). The study aimed to evaluate the predicting ability of N-terminal pro brain natriuretic peptide (N...

    Authors: Fengming Tian, Wen Song, Liang Wang, Qiang Zeng, Zhenyu Zhao, Ning Feng, Jiahui Fan, Yue Wang, Jing Wang and Xiumin Ma

    Citation: Respiratory Research 2021 22:321

    Content type: Research

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  18. Growing evidence suggests that cancer stem cells (CSCs) are responsible for cancer initiation in tumors. Bach1 has been identified to contribute to several tumor progression, including lung cancer. The role of...

    Authors: Pan Jiang, Fan Li, Zilong Liu, Shengyu Hao, Jian Gao and Shanqun Li

    Citation: Respiratory Research 2021 22:320

    Content type: Research

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  19. Tidal expiratory flow limitation (EFLT) is common among COPD patients. Whether EFLT changes during sleep and can be abolished during home ventilation is not known.

    Authors: J. McKenzie, P. Nisha, S. Cannon-Bailey, C. Cain, M. Kissel, J. Stachel, C. Proscyk, R. Romano, B. Hardy and P. M. A. Calverley

    Citation: Respiratory Research 2021 22:319

    Content type: Research

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  20. Sex and hormones influence immune responses to ischemia reperfusion (IR) and could, therefore, cause sex-related differences in lung transplantation (LTx) outcomes. We compared men’s and women’s clinical and m...

    Authors: Lourdes Chacon-Alberty, Shengbin Ye, Daoud Daoud, William C. Frankel, Hassan Virk, Jonathan Mase, Camila Hochman-Mendez, Meng Li, Luiz C. Sampaio, Doris A. Taylor and Gabriel Loor

    Citation: Respiratory Research 2021 22:318

    Content type: Research

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  21. Data on the safety and efficacy profile of tocilizumab in patients with severe COVID-19 needs to be enriched.

    Authors: Theodoros Karampitsakos, Elli Malakounidou, Ourania Papaioannou, Vasilina Dimakopoulou, Eirini Zarkadi, Matthaios Katsaras, Panagiota Tsiri, Georgios Tsirikos, Vasiliki Georgiopoulou, Ioanna Oikonomou, Christos Davoulos, Dimitrios Velissaris, Fotios Sampsonas, Markos Marangos, Karolina Akinosoglou and Argyris Tzouvelekis

    Citation: Respiratory Research 2021 22:317

    Content type: Research

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  22. Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In ...

    Authors: Ana I. Hernández Cordero, Chen Xi Yang, Xuan Li, Stephen Milne, Virginia Chen, Zsuzsanna Hollander, Raymond Ng, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, John E. Connett, MeiLan K. Han, Fernando J. Martinez, Robert M. Reed, S. F. Paul Man, Janice M. Leung…

    Citation: Respiratory Research 2021 22:316

    Content type: Research

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  23. Repetitive aeroallergen exposure is linked to sensitization and airway remodeling through incompletely understood mechanisms. In this study, we examine the dynamic mucosal response to cat dander extract (CDE),...

    Authors: Melissa E. Skibba, Xiaofang Xu, Kurt Weiss, Jan Huisken and Allan R. Brasier

    Citation: Respiratory Research 2021 22:315

    Content type: Research

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  24. Current criteria for surfactant administration assume that hypoxia is a direct marker of lung-volume de-recruitment. We first introduced an early, non-invasive assessment of lung mechanics by the Forced Oscill...

    Authors: Anna Lavizzari, Chiara Veneroni, Francesco Beretta, Valeria Ottaviani, Claudia Fumagalli, Marta Tossici, Mariarosa Colnaghi, Fabio Mosca and Raffaele L. Dellacà

    Citation: Respiratory Research 2021 22:314

    Content type: Research

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  25. Driving pressure (∆P) is an important factor that predicts mortality in acute respiratory distress syndrome (ARDS). We test the hypothesis that serial changes in daily ΔP rather than Day 1 ΔP would better pred...

    Authors: Hui-Chun Chang, Chung-Han Ho, Shu-Chen Kung, Wan-Lin Chen, Ching-Min Wang, Kuo-Chen Cheng, Wei-Lun Liu and Han-Shui Hsu

    Citation: Respiratory Research 2021 22:313

    Content type: Research

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  26. Hypoxic pulmonary hypertension (PH) is a refractory pulmonary vascular remodeling disease, and the efficiency of current PH treatment strategies is unsatisfactory. Tribbles homolog 3 (TRB3), a member of the ps...

    Authors: Xiaopei Cao, Xiaoyu Fang, Mingzhou Guo, Xiaochen Li, Yuanzhou He, Min Xie, Yongjian Xu and Xiansheng Liu

    Citation: Respiratory Research 2021 22:312

    Content type: Research

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  27. The prostaglandin D2 (PGD2) receptor 2 (DP2 receptor) pathway is an important regulator of the inflammatory cascade in asthma, which can be stimulated by allergic or non-allergic triggers. Fevipiprant is an oral,...

    Authors: Jorge Maspero, Ioana Octavia Agache, Tadashi Kamei, Makoto Yoshida, Bryan Boone, James M. Felser, Fernando Kawakami, Barbara Knorr, David Lawrence, Thomas Lehmann, Wei Wang and Andrew J. Pedinoff

    Citation: Respiratory Research 2021 22:311

    Content type: Research

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  28. Aetiology detection is crucial in the diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the detection method needs improvement. In this study, we used Nanopore sequencing to build a qu...

    Authors: Nan Wu, Piyush Ranjan, Changyu Tao, Chao Liu, Ence Yang, Bei He, John R. Erb-Downward, Shining Bo, Jiajia Zheng, Chenxia Guo, Beibei Liu, Lina Sun, Wei Yan, Meng Wang, Wenting Wang, Jianing Wen…

    Citation: Respiratory Research 2021 22:310

    Content type: Research

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  29. Preclinical studies implicate interleukin (IL)-1β as a key mediator of asthma and have shown the efficacy of IL-1 antagonism for treatment of allergic airway inflammation; human studies in this area are lacking.

    Authors: Allison J. Burbank, Stephen A. Schworer, Amika Sood, Martha Almond, Kelly Chason, Nathan Bean, Haibo Zhou and Michelle L. Hernandez

    Citation: Respiratory Research 2021 22:309

    Content type: Letter to the Editor

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  30. Tracheal injury is a common clinical condition that still lacks an effective therapy at present. Stimulation of epithelial sodium channel (ENaC) increases Na+ transport, which is a driving force to keep tracheal ...

    Authors: Xiaoyong Xie, Tong Yu, Yapeng Hou, Aixin Han, Yan Ding, Hongguang Nie and Yong Cui

    Citation: Respiratory Research 2021 22:308

    Content type: Research

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  31. As lung transplantation (LTx) is becoming a standard treatment for end-stage lung disease, the use of bridging with extracorporeal membrane oxygenation (ECMO) is increasing. We examined the clinical impact of ...

    Authors: Nam Eun Kim, Ala Woo, Song Yee Kim, Ah Young Leem, Youngmok Park, Se Hyun Kwak, Seung Hyun Yong, Kyungsoo Chung, Moo Suk Park, Young Sam Kim, Ha Eun Kim, Jin Gu Lee, Hyo Chae Paik and Su Hwan Lee

    Citation: Respiratory Research 2021 22:306

    Content type: Research

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  32. The intention of this short primer is to raise your appetite for proper quantitative assessment of lung micro-structure. The method of choice for obtaining such data is stereology. Rooted in stochastic geometr...

    Authors: Matthias Ochs and Julia Schipke

    Citation: Respiratory Research 2021 22:305

    Content type: Review

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  33. The mucociliary clearance system driven by beating cilia protects the airways from inhaled microbes and particles. Large particles are cleared by mucus bundles made in submucosal glands by parallel linear poly...

    Authors: Anna Ermund, Lauren N. Meiss, Brendan Dolan, Florian Jaudas, Lars Ewaldsson, Andrea Bähr, Nikolai Klymiuk and Gunnar C. Hansson

    Citation: Respiratory Research 2021 22:303

    Content type: Research

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  34. Lung cancer is the leading cause of cancer death worldwide. With the growing number of targeted therapies and the introduction of immuno-oncology (IO), personalized medicine has become standard of care in pati...

    Authors: Guus R. M. van den Heuvel, Leonie I. Kroeze, Marjolijn J. L. Ligtenberg, Katrien Grünberg, Erik A. M. Jansen, Daniel von Rhein, Richarda M. de Voer and Michel M. van den Heuvel

    Citation: Respiratory Research 2021 22:302

    Content type: Research

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  35. The clinical value of blood eosinophils and their stability in chronic obstructive pulmonary disease (COPD) remains controversial. There are limited studies on association between the stability of blood eosino...

    Authors: Yanan Cui, Wenye Zhang, Yiming Ma, Zijie Zhan and Yan Chen

    Citation: Respiratory Research 2021 22:301

    Content type: Research

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  36. Previous studies have determined the epigenetic association between DNA methylation and pulmonary function among various ethnics, whereas this association is largely unknown in Chinese adults. Thus, we aimed t...

    Authors: Tong Wang, Weijing Wang, Weilong Li, Haiping Duan, Chunsheng Xu, Xiaocao Tian and Dongfeng Zhang

    Citation: Respiratory Research 2021 22:300

    Content type: Research

    Published on:

  37. This study assessed the impact of the COVID-19 epidemic on overall hospitalizations for pulmonary embolism (PE) in France in comparison with previous years, and by COVID-19 and non-COVID-19 status.

    Authors: Pierre Tankere, Jonathan Cottenet, Pascale Tubert-Bitter, Anne-Sophie Mariet, Guillaume Beltramo, Jacques Cadranel, Lionel Piroth, Philippe Bonniaud and Catherine Quantin

    Citation: Respiratory Research 2021 22:298

    Content type: Research

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  38. Despite the high disease burden of chronic obstructive pulmonary disease (COPD) and risk of acute COPD exacerbation, few COPD biomarkers are available. As developmental endothelial locus-1 (DEL-1) has been pro...

    Authors: Dong-Hyun Joo, Kyoung-Hee Lee, Chang-Hoon Lee, Jisu Woo, Jiyeon Kim, Seoung Ju Park, Chin Kook Rhee, Won-Yeon Lee, Dongil Park, Jae Seung Lee, Ki-Suck Jung, Kwang Ha Yoo and Chul-Gyu Yoo

    Citation: Respiratory Research 2021 22:297

    Content type: Research

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  39. Cough hypersensitivity is a major characteristic feature associated with several types of cough, including chronic cough, but its underlying mechanisms remain to be fully understood. Inflammatory mediators, su...

    Authors: Al-Shaimaa A. Al-Kandery, Muddanna S. Rao and Ahmed Z. El-Hashim

    Citation: Respiratory Research 2021 22:296

    Content type: Research

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  40. α1-Antitrypsin (AAT) is an acute phase glycoprotein, a multifunctional protein with proteinase inhibitory, anti-inflammatory and cytoprotective properties. Both preclinical and clinical experiences show that t...

    Authors: Tomoyuki Nakagiri, Sabine Wrenger, Kokilavani Sivaraman, Fabio Ius, Tobias Goecke, Patrick Zardo, Veronika Grau, Tobias Welte, Axel Haverich, Ann-Kathrin Knöfel and Sabina Janciauskiene

    Citation: Respiratory Research 2021 22:295

    Content type: Research

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  41. Little attention has been paid to chest high resolution computed tomography (HRCT) findings in idiopathic pulmonary arterial hypertension (IPAH) patients so far, while a couple of small studies suggested that ...

    Authors: Aneta Kacprzak, Barbara Burakowska, Marcin Kurzyna, Anna Fijałkowska, Michał Florczyk, Maria Wieteska-Miłek, Szymon Darocha, Adam Torbicki and Monika Szturmowicz

    Citation: Respiratory Research 2021 22:293

    Content type: Research

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  42. Pursed-lips breathing (PLB) is a technique to attenuate small airway collapse by regulating the expiratory flow. During mandatory ventilation, flow-controlled expiration (FLEX), which mimics the expiratory flo...

    Authors: Johannes Schmidt, Anna Martin, Christin Wenzel, Jonas Weber, Steffen Wirth and Stefan Schumann

    Citation: Respiratory Research 2021 22:292

    Content type: Research

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  43. Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardi...

    Authors: Yun Ding, Pengjie Tu, Yiyong Chen, Yangyun Huang, Xiaojie Pan and Wenshu Chen

    Citation: Respiratory Research 2021 22:291

    Content type: Research

    Published on:

  44. Pleuroparenchymal fibroelastosis (PPFE) is characterised by predominant upper lobe pleural and subpleural lung parenchymal fibrosis. Radiological PPFE-like lesion has been associated with various types of inte...

    Authors: Tomoyuki Fujisawa, Yasuoki Horiike, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Kensuke Kataoka, Mikiko Hashisako, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura…

    Citation: Respiratory Research 2021 22:290

    Content type: Research

    Published on:

  45. For children and adults, the standard treatment for obstructive sleep apnea is the delivery of continuous positive airway pressure (CPAP). Though effective, CPAP masks can be uncomfortable to patients, contrib...

    Authors: Kelvin Duong, Michelle Noga, Joanna E. MacLean, Warren H. Finlay and Andrew R. Martin

    Citation: Respiratory Research 2021 22:289

    Content type: Research

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