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  1. Content type: Research

    Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsibl...

    Authors: Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq and Philippe Gosset

    Citation: Respiratory Research 2017 18:191

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  2. Content type: Commentary

    Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more re...

    Authors: Ianthe Piscaer, Emiel F. M. Wouters, Cees Vermeer, Wim Janssens, Frits M. E. Franssen and Rob Janssen

    Citation: Respiratory Research 2017 18:189

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  3. Content type: Letter to the Editor

    The main symptoms of patients with idiopathic pulmonary fibrosis (IPF) are cough and dyspnea. IPF leads to a restrictive lung disorder impacting daytime and nocturnal breathing patterns. In this pilot study we...

    Authors: Anke Schertel, Manuela Funke-Chambour, Thomas Geiser and Anne-Kathrin Brill

    Citation: Respiratory Research 2017 18:190

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  4. Content type: Research

    The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and conse...

    Authors: Stephane Esnault, Ksenija Bernau, Elizabeth E. Torr, Yury A. Bochkov, Nizar N. Jarjour and Nathan Sandbo

    Citation: Respiratory Research 2017 18:188

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  5. Content type: Research

    Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to respond to standard vasodilator therapy tar...

    Authors: Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel and Robbert J. Rottier

    Citation: Respiratory Research 2017 18:187

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  6. Content type: Research

    Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of cope...

    Authors: Jacob A. Winther, Jon Brynildsen, Arne Didrik Høiseth, Heidi Strand, Ivar Følling, Geir Christensen, Ståle Nygård, Helge Røsjø and Torbjørn Omland

    Citation: Respiratory Research 2017 18:184

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  7. Content type: Research

    Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, wh...

    Authors: Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva and Patricia Rieken Macedo Rocco

    Citation: Respiratory Research 2017 18:185

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  8. Content type: Research

    Revefenacin is a once-daily long-acting muscarinic antagonist (LAMA) in clinical development for the treatment of patients with chronic obstructive pulmonary disease (COPD). In a dose-ranging study, nebulized ...

    Authors: Krishna K. Pudi, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Edward Kerwin

    Citation: Respiratory Research 2017 18:182

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  9. Content type: Letter to the Editor

    Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the ...

    Authors: Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp…

    Citation: Respiratory Research 2017 18:181

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  10. Content type: Research

    Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in...

    Authors: Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P. Comellas, Prescott Woodruff, Wanda O’Neal, Dawn L. DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J. Castaldi, Craig Hersh, Edwin K. Silverman, James D. Crapo, Katerina Kechris and Russell P. Bowler

    Citation: Respiratory Research 2017 18:180

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  11. Content type: Research

    Bilirubin is a potent anti-oxidant and higher serum concentrations of bilirubin have been associated with better lung function, slower lung function decline, and lower incidence of chronic obstructive pulmonar...

    Authors: Kirstin E. Brown, Don D. Sin, Helen Voelker, John E. Connett, Dennis E. Niewoehner and Ken M. Kunisaki

    Citation: Respiratory Research 2017 18:179

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  12. Content type: Research

    Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of th...

    Authors: Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang and Pau-Chung Chen

    Citation: Respiratory Research 2017 18:178

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  13. Content type: Research

    Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome (ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-induced vascular injury. Recently, endothelial...

    Authors: Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi and James West

    Citation: Respiratory Research 2017 18:177

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  14. Content type: Research

    Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate fact...

    Authors: Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, Tomás Posadas, Laia Fernández-Barat and Antoni Torres

    Citation: Respiratory Research 2017 18:176

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  15. Content type: Research

    Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for cardiovascular (CV) disease, one of the most frequent causes of death in COPD patients. The goal of the present study was to evalu...

    Authors: Jorge Zagaceta, Gorka Bastarrika, Javier J. Zulueta, Inmaculada Colina, Ana B. Alcaide, Arantza Campo, Miguel Divo, Ciro Casanova, José M. Marin, Victor M. Pinto-Plata, Bartolome R. Celli and Juan P. de-Torres

    Citation: Respiratory Research 2017 18:175

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  16. Content type: Research

    Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors N...

    Authors: Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma and Hong Ye

    Citation: Respiratory Research 2017 18:174

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  17. Content type: Research

    Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway...

    Authors: S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby and Steven M. Rowe

    Citation: Respiratory Research 2017 18:173

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  18. Content type: Research

    Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR...

    Authors: Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara and Yasuhiko Nishioka

    Citation: Respiratory Research 2017 18:172

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  19. Content type: Research

    Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients w...

    Authors: Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier and Robert Bals

    Citation: Respiratory Research 2017 18:171

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  20. Content type: Research

    Regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in idiopathic pulmonary fibrosis (IPF) is unclear. This study was designed to explore the role of T...

    Authors: Ziliang Hou, Qiao Ye, Meihua Qiu, Yu Hao, Junyan Han and Hui Zeng

    Citation: Respiratory Research 2017 18:170

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  21. Content type: Research

    Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at dete...

    Authors: Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal and Manal S. Fawzy

    Citation: Respiratory Research 2017 18:169

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  22. Content type: Review

    Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have demonstrated that deficiency of ITSN-1s is a cruci...

    Authors: Niranjan Jeganathan, Dan Predescu and Sanda Predescu

    Citation: Respiratory Research 2017 18:168

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  23. Content type: Review

    Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the va...

    Authors: Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei and Judit E. Pongracz

    Citation: Respiratory Research 2017 18:167

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