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  1. Content type: Review

    Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease of unknown etiology. Over the past decade, macrophage has been recognized to play a significant role...

    Authors: Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu and Cong-Yi Wang

    Citation: Respiratory Research 2018 19:170

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  2. Content type: Research

    Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in sta...

    Authors: Masato Watanabe, Keitaro Nakamoto, Toshiya Inui, Mitsuru Sada, Kojiro Honda, Masaki Tamura, Yukari Ogawa, Takuma Yokoyama, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii and Hajime Takizawa

    Citation: Respiratory Research 2018 19:169

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  3. Content type: Research

    The benefits and risks of anti-acid medication in patients with idiopathic pulmonary fibrosis (IPF) remain a topic of debate. We investigated whether use of anti-acid medication at baseline was associated with...

    Authors: Ulrich Costabel, Jürgen Behr, Bruno Crestani, Wibke Stansen, Rozsa Schlenker-Herceg, Susanne Stowasser and Ganesh Raghu

    Citation: Respiratory Research 2018 19:167

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  4. Content type: Research

    Agriculture workers are exposed to microbial component- and particulate matter-enriched organic dust aerosols. Whereas it is clear that exposure to these aerosols can lead to lung inflammation, it is not known...

    Authors: Tricia D. LeVan, Debra J. Romberger, Mohammad Siahpush, Brandon L. Grimm, Athena K. Ramos, Patrik L. Johansson, Tzeyu L. Michaud, Art J. Heires, Todd A. Wyatt and Jill A. Poole

    Citation: Respiratory Research 2018 19:166

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  5. Content type: Research

    Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish...

    Authors: Christer Janson, Karin Lisspers, Björn Ställberg, Gunnar Johansson, Gunilla Telg, Marcus Thuresson, Helene Nordahl Christensen and Kjell Larsson

    Citation: Respiratory Research 2018 19:168

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  6. Content type: Research

    Gastric contents aspiration is a high-risk condition for acute lung injury (ALI). Consequences range from subclinical pneumonitis to respiratory failure, depending on the volume of aspirate. A large increment ...

    Authors: Pedro Ayala, Raúl Vivar, Rebeca Montalva, Pablo Olmos, Manuel Meneses and Gisella R. Borzone

    Citation: Respiratory Research 2018 19:165

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  7. Content type: Research

    Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare pulmonary disease caused by functional deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF therapy in aPAP has been report...

    Authors: Gaohong Sheng, Peng Chen, Yanqiu Wei, Jiaojiao Chu, Xiaolei Cao and Hui-Lan Zhang

    Citation: Respiratory Research 2018 19:163

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  8. Content type: Letter to the Editor

    Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unli...

    Authors: Pasquale Caponnetto, Marilena Maglia, Gaetano Prosperini, Barbara Busà and Riccardo Polosa

    Citation: Respiratory Research 2018 19:164

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  9. Content type: Research

    Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluat...

    Authors: Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Toyofumi F. Chen-Yoshikawa, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Akihiko Yoshizawa, Yohei Oshima, Kohei Ikezoe, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Murase, Sonoko Nagai, Shigeo Muro, Toru Oga…

    Citation: Respiratory Research 2018 19:162

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  10. Content type: Research

    Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and impr...

    Authors: Sabrina Mueller, Fraence Gottschalk, Antje Groth, Wilhelmine Meeraus, Maurice Driessen, Thomas Kohlmann and Thomas Wilke

    Citation: Respiratory Research 2018 19:161

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  11. Content type: Research

    Sex differences in idiopathic pulmonary fibrosis (IPF) suggest a protective role for estrogen (E2); however, mechanistic studies in animal models have produced mixed results. Reports using cell lines have inve...

    Authors: L. Cody Smith, Santiago Moreno, Lauren Robertson, Sarah Robinson, Kristal Gant, Andrew J. Bryant and Tara Sabo-Attwood

    Citation: Respiratory Research 2018 19:160

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  12. Content type: Research

    Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significa...

    Authors: Tamás Dolinay, Chanat Aonbangkhen, William Zacharias, Edward Cantu, Jennifer Pogoriler, Alec Stablow, Gladys G. Lawrence, Yoshikazu Suzuki, David M. Chenoweth, Edward Morrisey, Jason D. Christie, Michael F. Beers and Susan S. Margulies

    Citation: Respiratory Research 2018 19:157

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  13. Content type: Research

    The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants. A family based study of predominantly smoking adu...

    Authors: Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos…

    Citation: Respiratory Research 2018 19:156

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  14. Content type: Research

    Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely unknown. This study examines whether changes in versica...

    Authors: Annie R. A. McDougall, Amanda J. Fosang, Jessica Faggian, Megan J. Wallace, Kelly J. Crossley, Timothy J. Cole and Stuart B. Hooper

    Citation: Respiratory Research 2018 19:155

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  15. Content type: Research

    The Asthma Control Test (ACT) is widely used to assess asthma control, yet the validity and reliability of the test have not been specifically evaluated in adolescents or African-Americans. We conducted a pros...

    Authors: Allison J. Burbank, Krista Todoric, Pamela Steele, Jonathan Rosen, Haibo Zhou, Marcia Frye, Ceila E. Loughlin, Sally Ivins, Katherine Mills, Lauren Dembnicki Massey, Bryce B. Reeve and Michelle L. Hernandez

    Citation: Respiratory Research 2018 19:152

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  16. Content type: Research

    The clinical-radiographic distinction between idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) is challenging. We sought to investigate the gene expression profiles of IPF and...

    Authors: Matthew J. Cecchini, Karishma Hosein, Christopher J. Howlett, Mariamma Joseph and Marco Mura

    Citation: Respiratory Research 2018 19:153

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  17. Content type: Review

    Lung cancer ranks as the leading cause of cancer-related deaths worldwide and we performed this meta-analysis to investigate eligible studies and determine the prognostic effect of Ki-67.

    Authors: Dan-ming Wei, Wen-jie Chen, Rong-mei Meng, Na Zhao, Xiang-yu Zhang, Dan-yu Liao and Gang Chen

    Citation: Respiratory Research 2018 19:150

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  18. Content type: Research

    Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleoti...

    Authors: Timm Greulich, Francisco Rodríguez-Frias, Irene Belmonte, Andreas Klemmer, Claus F. Vogelmeier and Marc Miravitlles

    Citation: Respiratory Research 2018 19:151

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  19. Content type: Review

    Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions a...

    Authors: José Alberto Rodríguez-Castillo, David Bravo Pérez, Aglaia Ntokou, Werner Seeger, Rory E. Morty and Katrin Ahlbrecht

    Citation: Respiratory Research 2018 19:148

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  20. Content type: Letter to the Editor

    It is recommended that screening for COPD be restricted to symptomatic individuals, but supporting evidence is lacking. We determined the performance of wheeze, cough, phlegm, and dyspnea in discriminating COP...

    Authors: Kate M. Johnson, Wan C. Tan, Jean Bourbeau, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:147

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  21. Content type: Research

    Specific microRNAs (miRNAs) play essential roles in airway remodeling in asthma. Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. However, ...

    Authors: Fatemeh Moheimani, Jorinke Koops, Teresa Williams, Andrew T. Reid, Philip M. Hansbro, Peter A. Wark and Darryl A. Knight

    Citation: Respiratory Research 2018 19:145

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  22. Content type: Research

    Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells. Bronchial epithel...

    Authors: Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight and Jason S. Debley

    Citation: Respiratory Research 2018 19:146

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  23. Content type: Research

    Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluatio...

    Authors: Kentaro Nakashima, Takashi Sato, Suguru Shigemori, Takeshi Shimosato, Masaharu Shinkai and Takeshi Kaneko

    Citation: Respiratory Research 2018 19:144

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  24. Content type: Research

    COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies of pneum...

    Authors: Nicholas P. Williams, Kristoffer Ostridge, Jeanne-Marie Devaster, Viktoriya Kim, Ngaire A. Coombs, Simon Bourne, Stuart C. Clarke, Stephen Harden, Ausami Abbas, Emmanuel Aris, Christophe Lambert, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson

    Citation: Respiratory Research 2018 19:143

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  25. Content type: Research

    Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research.

    Authors: Andreas Guenther, Ekaterina Krauss, Silke Tello, Jasmin Wagner, Bettina Paul, Stefan Kuhn, Olga Maurer, Sabine Heinemann, Ulrich Costabel, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol Wells, Martina Vasakova, Alberto Pesci…

    Citation: Respiratory Research 2018 19:141

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  26. Content type: Research

    Probiotics could prevent Pseudomonas aeruginosa colonization in lower respiratory tract (LRT) and reduced P. aeruginosa ventilator-associated pneumonia (VAP) rate. Recent studies also suggested that probiotics co...

    Authors: Xiaoling Qi, Hongping Qu, Dandan Yang, Lian Zhou, Ya-Wen He, Yuetian Yu, Jieming Qu and Jialin Liu

    Citation: Respiratory Research 2018 19:139

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  27. Content type: Research

    Persons living with human immunodeficiency virus (PLWH) face an increased burden of chronic obstructive pulmonary disease (COPD). Repeated pulmonary infections, antibiotic exposures, and immunosuppression may ...

    Authors: Stella Xu, Amy Tsai, Marc A. Sze, Emily A. Vucic, Tawimas Shaipanich, Marianne Harris, Silvia Guillemi, Julia Yang, Sunita Sinha, Corey Nislow, Julio Montaner, Wan Lam, Stephen Lam, Don D. Sin, S. F. Paul Man and Janice M. Leung

    Citation: Respiratory Research 2018 19:140

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  28. Content type: Research

    The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. ...

    Authors: Torsten Goldmann, Gernot Zissel, Henrik Watz, Daniel Drömann, Martin Reck, Christian Kugler, Klaus F. Rabe and Sebastian Marwitz

    Citation: Respiratory Research 2018 19:138

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  29. Content type: Research

    Trials of disease modifying therapies in Chronic Obstructive Pulmonary Disease (COPD) provide challenges for detecting physiological and patient centred outcomes. The purpose of the current study was to monito...

    Authors: Robert A. Stockley, Ross G. Edgar, Sian Starkey and Alice M. Turner

    Citation: Respiratory Research 2018 19:137

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  30. Content type: Review

    Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene, which encodes for a protein responsible for ion transport out of epithel...

    Authors: Nathan Rout-Pitt, Nigel Farrow, David Parsons and Martin Donnelley

    Citation: Respiratory Research 2018 19:136

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  31. Content type: Research

    Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onse...

    Authors: George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley and James Fingleton

    Citation: Respiratory Research 2018 19:133

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  32. Content type: Research

    Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association be...

    Authors: Sun Hye Shin, Hye Yun Park, Danbee Kang, Juhee Cho, Sung Ok Kwon, Joo Hun Park, Jae Seung Lee, Yeon-Mok Oh, Don D. Sin, Woo Jin Kim and Sang-Do Lee

    Citation: Respiratory Research 2018 19:134

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  33. Content type: Research

    Idiopathic pulmonary fibroelastosis (iPPFE) is a rare lung lesion characterized by pleural and subpleural parenchymal thickening due to accumulation of fibroelastotic tissue. Only recently, a few cases with a ...

    Authors: Sissel Kronborg-White, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Sara Tomassetti, Elisabeth Bendstrup and Venerino Poletti

    Citation: Respiratory Research 2018 19:135

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  34. Content type: Research

    Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the ex...

    Authors: John E. McDonough, Dries S. Martens, Naoya Tanabe, Farida Ahangari, Stijn E. Verleden, Karen Maes, Geert M. Verleden, Naftali Kaminski, James C. Hogg, Tim S. Nawrot, Wim A. Wuyts and Bart M. Vanaudenaerde

    Citation: Respiratory Research 2018 19:132

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  35. Content type: Research

    Cigarette smoke exposure can affect pulmonary lipid homeostasis and cause a progressive increase in pulmonary antibodies against oxidized low-density lipoproteins (OxLDL). Similarly, increased anti-OxLDL antib...

    Authors: Maude Talbot, Mélanie Hamel-Auger, Marie-Josée Beaulieu, Morgan Gazzola, Ariane Lechasseur, Sophie Aubin, Marie-Ève Paré, David Marsolais, Ynuk Bossé and Mathieu C. Morissette

    Citation: Respiratory Research 2018 19:131

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  36. Content type: Research

    Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in th...

    Authors: Carl M. Philpott, Sally Erskine, Claire Hopkins, Nirmal Kumar, Shahram Anari, Naveed Kara, Sankalp Sunkaraneni, Jaydip Ray, Allan Clark, Andrew Wilson, Sally Erskine, Carl Philpott, Allan Clark, Claire Hopkins, Alasdair Robertson, Shahzada Ahmed…

    Citation: Respiratory Research 2018 19:129

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  37. Content type: Research

    Circulating microRNAs have shown promise as non-invasive biomarkers and predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic data have not shown excellent prediction of ...

    Authors: Alvin T. Kho, Michael J. McGeachie, Kip G. Moore, Jody M. Sylvia, Scott T. Weiss and Kelan G. Tantisira

    Citation: Respiratory Research 2018 19:128

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  38. Content type: Research

    Pulmonary fibrosis is a progressive and lethal disease characterized by damage to the lung parenchyma with excess extracellular matrix deposition. The involvement of endothelial cells in fibrosis development i...

    Authors: Shinpei Kato, Naoki Inui, Akio Hakamata, Yuzo Suzuki, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe and Takafumi Suda

    Citation: Respiratory Research 2018 19:127

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  39. Content type: Research

    Airway epithelial cells and alveolar macrophages (AMs) are the first line of defense in the lung during infection. Toll-like receptor (TLR) agonists have been extensively used to define the regulation of infla...

    Authors: Reem Al Mubarak, Nicole Roberts, Robert J. Mason, Scott Alper and Hong Wei Chu

    Citation: Respiratory Research 2018 19:126

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  40. Content type: Research

    Primary ciliary dyskinesia can result from a number of different ciliary defects that adversely affect ciliary function resulting markedly reduced or absent mucociliary clearance. Improvement in diagnostic tes...

    Authors: Chris O’Callaghan, Andrew Rutman, Gwyneth Williams, Neeta Kulkarni, Joseph Hayes and Robert A. Hirst

    Citation: Respiratory Research 2018 19:125

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  41. Content type: Research

    Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vit...

    Authors: Lu Wang, Nannan Zhang, Yi Zhang, Jingen Xia, Qingyuan Zhan and Chen Wang

    Citation: Respiratory Research 2018 19:122

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  42. Content type: Review

    The Human Viral Challenge (HVC) model has, for many decades, helped in the understanding of respiratory viruses and their role in disease pathogenesis. In a controlled setting using small numbers of volunteers...

    Authors: Rob Lambkin-Williams, Nicolas Noulin, Alex Mann, Andrew Catchpole and Anthony S. Gilbert

    Citation: Respiratory Research 2018 19:123

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  43. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a progressive disease and a composite endpoint could be an indicator of treatment effect on disease worsening. This post-hoc analysis assessed whether indacatero...

    Authors: Antonio R. Anzueto, Konstantinos Kostikas, Karen Mezzi, Steven Shen, Michael Larbig, Francesco Patalano, Robert Fogel, Donald Banerji and Jadwiga A. Wedzicha

    Citation: Respiratory Research 2018 19:121

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