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  1. Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral ...

    Authors: Alexandra Arvanitaki, George Giannakoulas, Eva Triantafyllidou, Christos Feloukidis, Afroditi K. Boutou, Alexandros Garyfallos, Haralambos Karvounis and Theodoros Dimitroulas

    Citation: Respiratory Research 2021 22:27

    Content type: Research

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  2. When infected with Mycobacterium tuberculosis, only a small proportion of the population will develop active TB, and the role of host genetic factors in different TB infection status was not fully understood.

    Authors: Jing-Wen Ai, Hanyue Zhang, Zumo Zhou, Shanshan Weng, Heqing Huang, Sen Wang, Lingyun Shao, Yan Gao, Jing Wu, Qiaoling Ruan, Feifei Wang, Ning Jiang, Jiazhen Chen and Wenhong Zhang

    Citation: Respiratory Research 2021 22:23

    Content type: Research

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  3. Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary disease (COPD). Our previous studies have validated N...

    Authors: Dan-dan Zong, Xiang-ming Liu, Jin-hua Li, Ruo-yun Ouyang, Ying-jiao Long, Ping Chen and Yan Chen

    Citation: Respiratory Research 2021 22:22

    Content type: Research

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  4. COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVI...

    Authors: Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni, John C. Marshall and Michael A. Portman

    Citation: Respiratory Research 2021 22:20

    Content type: Research

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  5. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, ...

    Authors: Rachel Lam, Sophia Kwon, Jessica Riggs, Maria Sunseri, George Crowley, Theresa Schwartz, Rachel Zeig-Owens, Hilary Colbeth, Allison Halpren, Mengling Liu, David J. Prezant and Anna Nolan

    Citation: Respiratory Research 2021 22:19

    Content type: Research

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  6. Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship be...

    Authors: Toru Shirahata, Hideaki Sato, Sanehiro Yogi, Kaiji Inoue, Mamoru Niitsu, Tomoe Akagami, Machika Soma, Tomohiko Mio, Makoto Nagata, Satoshi Nakae, Yuki Nishida, Shigeho Tanaka, Fuminori Katsukawa and Hidetoshi Nakamura

    Citation: Respiratory Research 2021 22:18

    Content type: Research

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  7. For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the re...

    Authors: Marie-Caroline Rotty, Carey M. Suehs, Jean-Pierre Mallet, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Fanny Bertelli, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel

    Citation: Respiratory Research 2021 22:17

    Content type: Research

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  8. Some studies investigated epidemiological and clinical features of laboratory-confirmed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus causing coronavirus disease 2019 (CO...

    Authors: Giovanna E. Carpagnano, Giovanni Migliore, Salvatore Grasso, Vito Procacci, Emanuela Resta, Francesco Panza and Onofrio Resta

    Citation: Respiratory Research 2021 22:16

    Content type: Research

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  9. Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of asthmatics older than 70 years old as compared to younger pat...

    Authors: F. Schleich, S. Graff, F. Guissard, M. Henket, V. Paulus and R. Louis

    Citation: Respiratory Research 2021 22:15

    Content type: Research

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  10. In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, ...

    Authors: Flora Lemaire, Sandra Audonnet, Jeanne-Marie Perotin, Pierre Gaudry, Sandra Dury, Julien Ancel, François Lebargy, Frank Antonicelli, Gaëtan Deslée and Richard Le Naour

    Citation: Respiratory Research 2021 22:14

    Content type: Research

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  11. It is essential to avoid admission of patients with undetected corona virus disease 2019 (COVID-19) to hospitals’ general wards. Even repeated negative reverse transcription polymerase chain reaction (RT-PCR) ...

    Authors: Ulf Teichgräber, Amer Malouhi, Maja Ingwersen, Rotraud Neumann, Marina Reljic, Stefanie Deinhardt-Emmer, Bettina Löffler, Wilhelm Behringer, Jan-Christoph Lewejohann, Andreas Stallmach and Philipp Reuken

    Citation: Respiratory Research 2021 22:13

    Content type: Research

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  12. In their letter-to-the-editor entitled “Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19”, Tobin et al. (Respir Res 21:249, 2020) debated our views on happy hypo...

    Authors: Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt and Bart N. Lambrecht

    Citation: Respiratory Research 2021 22:12

    Content type: Letter to the Editor

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    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:249

    The Review to this article has been published in Respiratory Research 2020 21:198

  13. For antibiotic treatment of Acute exacerbations of COPD (AECOPD) the National guidelines in Denmark recommend either first choice amoxicillin 750 mg TID (AMX) or amoxicillin with clavulanic acid 500 mg/125 mg ...

    Authors: Kristian Bagge, Pradeesh Sivapalan, Josefin Eklöf, Frederik Böetius Hertz, Christian Østergaard Andersen, Ejvind Frausing Hansen, Jens Otto Jarløv and Jens-Ulrik Stæhr Jensen

    Citation: Respiratory Research 2021 22:11

    Content type: Research

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  14. Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are nee...

    Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock and Kian Fan Chung

    Citation: Respiratory Research 2021 22:10

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2021 22:47

  15. It is important to identify deterioration in normotensive patients with acute pulmonary embolism (PE). This study aimed to develop a tool for predicting deterioration among normotensive patients with acute PE ...

    Authors: Yizhuo Gao, Chao Ji, Hongyu Zhao, Jun Han, Haitao Shen and Dong Jia

    Citation: Respiratory Research 2021 22:9

    Content type: Research

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  16. Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulat...

    Authors: Heshen Tian, Lei Liu, Ying Wu, Ruiwen Wang, Yongliang Jiang, Ruicheng Hu, Liming Zhu, Linwei Li, Yanyan Fang, Chulan Yang, Lianzhi Ji, Guoyu Liu and Aiguo Dai

    Citation: Respiratory Research 2021 22:8

    Content type: Research

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  17. Diabetes is a common comorbidity among patients with exacerbation of chronic obstructive pulmonary disease (AECOPD). Diabetes has been reported to be associated with length of stay (LOS), death, and cost among...

    Authors: Xihua Mao, Chen Liang, Hongtao Niu, Fen Dong, Ke Huang, Yahong Chen, Kewu Huang, Qingyuan Zhan, Yaowen Zhang, Yin Huang, Ting Yang and Chen Wang

    Citation: Respiratory Research 2021 22:7

    Content type: Research

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  18. Chronic sputum production in the general population is historically associated with clinical indices including male sex and smoking history. However, its relationship with gastroesophageal reflux disease (GERD...

    Authors: Chie Morimoto, Hisako Matsumoto, Tadao Nagasaki, Yoshihiro Kanemitsu, Yumi Ishiyama, Hironobu Sunadome, Tsuyoshi Oguma, Isao Ito, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Akio Niimi, Shigeo Muro, Fumihiko Matsuda, Kazuo Chin and Toyohiro Hirai

    Citation: Respiratory Research 2021 22:6

    Content type: Research

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  19. There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional ch...

    Authors: Jean Pastre, Scott Barnett, Inga Ksovreli, Jeannie Taylor, A. Whitney Brown, Oksana A. Shlobin, Kareem Ahmad, Vikramjit Khangoora, Shambhu Aryal, Christopher S. King and Steven D. Nathan

    Citation: Respiratory Research 2021 22:5

    Content type: Research

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  20. Happy hypoxemia is an unspecified definition that is used in COVID-19 patients to define hypoxemia without dyspnoea. Dyspnoea is a very complex symptom, and although hypoxemia can cause breathlessness, dyspnoe...

    Authors: Josuel Ora, Paola Rogliani, Mario Dauri and Denis O’Donnell

    Citation: Respiratory Research 2021 22:4

    Content type: Letter to the Editor

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  21. Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely be...

    Authors: Ya-Sian Chang, Siang-Jyun Tu, Yu-Chia Chen, Ting-Yuan Liu, Ya-Ting Lee, Ju-Chen Yen, Hsin-Yuan Fang and Jan-Gowth Chang

    Citation: Respiratory Research 2021 22:3

    Content type: Research

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  22. ALI/ARDS is a severe lung injury leading to refractory respiratory failure, accounting for high morbidity and mortality. However, therapeutic approaches are rather limited. Targeting long non-coding RNA MALAT1...

    Authors: Yaling Liu, Xiaodong Wang, Peiying Li, Yanhua Zhao, Liqun Yang, Weifeng Yu and Hong Xie

    Citation: Respiratory Research 2021 22:1

    Content type: Research

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  23. Thymosin β10 (TMSB10) has been reported to play a protumorigenic role in a majority of solid cancers. However, the existence of TMSB10 in immune microenvironment may contribute to the pathogenesis of lung aden...

    Authors: Jun Zeng, Xianggui Yang, Li Yang, Wancheng Li and Yaxin Zheng

    Citation: Respiratory Research 2020 21:328

    Content type: Research

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  24. Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.

    Authors: Ryota Dokuni, Tatsuya Nagano, Naoe Jimbo, Hiroki Sato, Tatsunori Kiriu, Yuichiro Yasuda, Masatsugu Yamamoto, Motoko Tachihara, Kazuyuki Kobayashi, Yoshimasa Maniwa and Yoshihiro Nishimura

    Citation: Respiratory Research 2020 21:331

    Content type: Research

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  25. Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway infl...

    Authors: Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht and Annelie F. Behndig

    Citation: Respiratory Research 2020 21:330

    Content type: Research

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  26. Acute lung injury (ALI) is a clinical syndrome with high morbidity and mortality, and severe pulmonary edema is one of the characteristics. Epithelial sodium channel (ENaC) located on the apical side of alveol...

    Authors: Honglei Zhang, Yan Ding, Yapeng Hou, Yanhong Liu, Zhiyu Zhou and Hongguang Nie

    Citation: Respiratory Research 2020 21:329

    Content type: Research

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  27. Since the coronavirus disease 2019 (COVID-19) identified in Wuhan, Hubei, China in December 2019, it has been characterized as a pandemic by World Health Organization (WHO). It was reported that asymptomatic p...

    Authors: Chaojie Wei, Yufeng Yuan and Zhenshun Cheng

    Citation: Respiratory Research 2020 21:327

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:21

  28. Pulmonary infections are associated with a brisk inflammatory reaction to bacterial surface components. Lipopolysaccharides (LPS) trigger macrophage activation and release of mitochondrial metabolites that con...

    Authors: Sebastián A. Riquelme and Alice Prince

    Citation: Respiratory Research 2020 21:326

    Content type: Review

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  29. Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of th...

    Authors: Longxiang Su, Zhongheng Zhang, Fanglan Zheng, Pan Pan, Na Hong, Chun Liu, Jie He, Weiguo Zhu, Yun Long and Dawei Liu

    Citation: Respiratory Research 2020 21:325

    Content type: Research

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  30. Noninvasive ventilation (NIV) represents an effective treatment for chronic respiratory failure. However, empirically determined NIV settings may not achieve optimal ventilatory support. Therefore, the efficac...

    Authors: Marjolaine Georges, Claudio Rabec, Elise Monin, Serge Aho, Guillaume Beltramo, Jean-Paul Janssens and Philippe Bonniaud

    Citation: Respiratory Research 2020 21:324

    Content type: Research

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  31. The effects of triple therapy on gas trapping in COPD are not fully understood. We evaluated the effects of the long acting bronchodilator components of the extrafine single inhaler triple therapy beclometason...

    Authors: James Dean, Catalina Panainte, Naimat Khan and Dave Singh

    Citation: Respiratory Research 2020 21:323

    Content type: Research

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  32. Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbiditi...

    Authors: Alyson W. Wong, Tae Yoon Lee, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Charlene D. Fell, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Gerard Cox, Andrew J. Halayko, Nathan Hambly, Helene Manganas, Mohsen Sadatsafavi, Pearce G. Wilcox, Teresa To…

    Citation: Respiratory Research 2020 21:322

    Content type: Research

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  33. Despite the availability of multi-“omics” strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity o...

    Authors: Nancy G. Casanova, Manuel L. Gonzalez-Garay, Belinda Sun, Christian Bime, Xiaoguang Sun, Kenneth S. Knox, Elliott D. Crouser, Nora Sammani, Taylor Gonzales, Bhupinder Natt, Sachin Chaudhary, Yves Lussier and Joe G. N. Garcia

    Citation: Respiratory Research 2020 21:321

    Content type: Research

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  34. The disposable bronchoscope is an excellent alternative to face the problem of SARS-CoV-2 and other cross infections, but the bronchoscopist's perception of its quality has not been evaluated.

    Authors: Javier Flandes, Luis Fernando Giraldo-Cadavid, Javier Alfayate, Iker Fernández-Navamuel, Carlos Agusti, Carmen M. Lucena, Antoni Rosell, Felipe Andreo, Carmen Centeno, Carmen Montero, Iria Vidal, Lucía García-Alfonso, Antonio Bango, Miguel Ariza, Rocío Gallego, Marta Orta…

    Citation: Respiratory Research 2020 21:320

    Content type: Research

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  35. Exacerbation of chronic obstructive pulmonary disease (COPD) severely impacts the quality of life and causes high mortality and morbidity. COPD is involved with systemic and pulmonary inflammation, which may b...

    Authors: Meng-Ting Wang, Jyun-Heng Lai, Ya-Ling Huang, Feng-Chih Kuo, Yun-Han Wang, Chen-Liang Tsai and Min-Yu Tu

    Citation: Respiratory Research 2020 21:319

    Content type: Research

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  36. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the group of Betacoronaviruses. The SARS-CoV-2 is closely related to SARS-CoV-1 and probably originated either from bats or pangolins. SA...

    Authors: Meghana Rastogi, Neha Pandey, Astha Shukla and Sunit K. Singh

    Citation: Respiratory Research 2020 21:318

    Content type: Review

    Published on:

  37. Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airwa...

    Authors: Shengjie Xu, Anthony Schwab, Nikhil Karmacharya, Gaoyuan Cao, Joanna Woo, Nicholas Kim, Steven S. An, Reynold A. Panettieri Jr and Joseph A. Jude

    Citation: Respiratory Research 2020 21:317

    Content type: Research

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  38. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. ...

    Authors: Kimiyuki Ikeda, Hirofumi Chiba, Hirotaka Nishikiori, Arata Azuma, Yasuhiro Kondoh, Takashi Ogura, Yoshio Taguchi, Masahito Ebina, Hiroki Sakaguchi, Shogo Miyazawa, Moritaka Suga, Yukihiko Sugiyama, Toshihiro Nukiwa, Shoji Kudoh and Hiroki Takahashi

    Citation: Respiratory Research 2020 21:316

    Content type: Research

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  39. We would like to comment on the article entitled “Association between cytokine profiles and lung injury in COVID-19 pneumonia” by Li-Da Chen and colleagues, with respect to emerging data regarding the immunopa...

    Authors: Jaya Ponnampalam, George Seligmann, Tanaya Gandhi and Dilen Parmar

    Citation: Respiratory Research 2020 21:315

    Content type: Letter to the Editor

    Published on:

    The original article was published in Respiratory Research 2020 21:201

  40. Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed...

    Authors: Siqin Zhang, Lin Liu, Bin Yang, Rou Li, Jianhua Luo, Jing Huang, Yanjun Long, Ying Huang, Jianping Zhou, Yan Zha and Xiangyan Zhang

    Citation: Respiratory Research 2020 21:314

    Content type: Research

    Published on:

  41. The clinical characteristics and outcomes of the 2019 novel coronavirus (COVID-19) pneumonia are different in Hubei compared to other regions in China. But there are few comparative studies on the differences ...

    Authors: Chang Wang, Lizhi Zhou, Juan Chen, Yong Yang, Tianlong Huang, Min Fu, Ya Li, Daniel M. George and Xiangyu Chen

    Citation: Respiratory Research 2020 21:313

    Content type: Research

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  42. Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are ass...

    Authors: Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma and Vincent Cottin

    Citation: Respiratory Research 2020 21:312

    Content type: Research

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  43. Sexual function is often affected in patients suffering from chronic diseases especially chronic obstructive pulmonary disease (COPD). However, the effect of COPD on sexual satisfaction is underappreciated in ...

    Authors: M. Zysman, J. Rubenstein, F. Le Guillou, R. M. H. Colson, C. Pochulu, L. Grassion, R. Escamilla, D. Piperno, J. Pon, S. Khan and C. Raherison-Semjen

    Citation: Respiratory Research 2020 21:311

    Content type: Research

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  44. Only few randomized controlled trials (RCTs) for head-to-head comparison have been conducted between various combinations of long-acting muscarinic antagonists (LAMAs) and long-acting beta-agonists (LABAs). Ou...

    Authors: Hyun Woo Lee, Jimyung Park, Eun Jin Jang and Chang-Hoon Lee

    Citation: Respiratory Research 2020 21:310

    Content type: Research

    Published on:

  45. Coronavirus disease COVID-19 has become a public health emergency of international concern. Together with the quest for an effective treatment, the question of the post-infectious evolution of affected patient...

    Authors: AN Frix, L. Schoneveld, A. Ladang, M. Henket, B. Duysinx, F. Vaillant, B. Misset, M. Moutschen, R. Louis, E. Cavalier and J. Guiot

    Citation: Respiratory Research 2020 21:309

    Content type: Letter to the Editor

    Published on:

  46. Despite demonstrated symptomatic benefit from bronchial thermoplasty (BT), the underlying pathophysiological benefits have been uncertain. The purpose of the present study was to relate clinical benefit after ...

    Authors: David Langton, Kim Bennetts, Francis Thien, Virginia Plummer and Peter B. Noble

    Citation: Respiratory Research 2020 21:308

    Content type: Research

    Published on:

  47. The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS...

    Authors: Fengyun Wang, Bin Fang, Xinhua Qiang, Jingsong Shao and Lixin Zhou

    Citation: Respiratory Research 2020 21:307

    Content type: Research

    Published on:

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