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  1. The PROOF registry is an observational study initiated in October 2013 with the aim to monitor disease progression in a real-world population of patients with idiopathic pulmonary fibrosis (IPF). Here, we pres...

    Authors: Wim A. Wuyts, Caroline Dahlqvist, Hans Slabbynck, Marc Schlesser, Natacha Gusbin, Christophe Compere, Sofie Maddens, Yuan-Chi Lee, Klaus-Uwe Kirchgaessler, Karen Bartley and Benjamin Bondue

    Citation: Respiratory Research 2019 20:231

    Content type: Research

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  2. In mammalian cells, Aurora serine/threonine kinases (Aurora A, B, and C) are expressed in a cell cycle-dependent fashion as key mitotic regulators required for the maintenance of chromosomal stability. Aurora-...

    Authors: Ningbo Liu, Yong Antican Wang, Yunguang Sun, Jeffrey Ecsedy, Jifeng Sun, Xue Li and Ping Wang

    Citation: Respiratory Research 2019 20:230

    Content type: Research

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  3. Asthma-COPD overlap (ACO) is a term that encompasses patients with features of both asthma and COPD. To date, the global prevalence of ACO in the general population remains unknown. The objective of this study...

    Authors: Mostafa Hosseini, Amir Almasi-Hashiani, Mahdi Sepidarkish and Saman Maroufizadeh

    Citation: Respiratory Research 2019 20:229

    Content type: Review

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  4. Antiviral drugs such as rupintrivir may have an immune-modulatory effect in experimentally induced allergic asthma with subsequent RV infection. We infected lung slices of house-dust mite (HDM)-sensitized asth...

    Authors: Olga Danov, Lisa Lasswitz, Helena Obernolte, Christina Hesse, Armin Braun, Sabine Wronski and Katherina Sewald

    Citation: Respiratory Research 2019 20:228

    Content type: Research

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  5. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development....

    Authors: Jamie L. Todd, Megan L. Neely, Robert Overton, Katey Durham, Mridu Gulati, Howard Huang, Jesse Roman, L. Kristin Newby, Kevin R. Flaherty, Richard Vinisko, Yi Liu, Janine Roy, Ramona Schmid, Benjamin Strobel, Christian Hesslinger, Thomas B. Leonard…

    Citation: Respiratory Research 2019 20:227

    Content type: Research

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  6. Muscle wasting is associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). The cross-sectional area of skeletal muscles on computed tomography (CT) could serve as a method to ev...

    Authors: So Hyeon Bak, Sung Ok Kwon, Seon-Sook Han and Woo Jin Kim

    Citation: Respiratory Research 2019 20:226

    Content type: Research

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  7. Significant evidence has shown that the miRNA pathway is an important component in the downstream signaling cascades of TGF-β1 pathway. Our previous study has indicated that miR-335-5p expression was significa...

    Authors: Wenwen Du, Haicheng Tang, Zhe Lei, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu and Jian-an Huang

    Citation: Respiratory Research 2019 20:225

    Content type: Research

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  8. The incidence of infectious disease caused by nontuberculous mycobacteria is increasing worldwide. Pulmonary Mycobacterium avium complex (MAC) disease is difficult to treat with chemotherapy, and its mechanism of...

    Authors: Tomofumi Kobayashi, Koji Kuronuma, Atsushi Saito, Kimiyuki Ikeda, Shigeru Ariki, Atsushi Saitou, Mitsuo Otsuka, Hirofumi Chiba, Satoshi Takahashi, Motoko Takahashi and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:224

    Content type: Research

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  9. Primary drug-resistant tuberculosis (DR-TB) has contributed to a significant health and economic burden on a global scale, especially in China. we sought to estimate epidemiological characteristics of primary ...

    Authors: Wan-mei Song, Yi-fan Li, Xiao-bin Ma, Jin-yue Liu, Ning-ning Tao, Yao Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Chun-Bao Yu, Lei Gao, Liang-liang Cui and Huai-chen Li

    Citation: Respiratory Research 2019 20:223

    Content type: Research

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  10. Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impa...

    Authors: Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills and Alaina J. Ammit

    Citation: Respiratory Research 2019 20:222

    Content type: Review

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  11. Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease resulting in severe respiratory derangements. As such, DMD patients are at a high risk of nocturnal hypoventilation, thereby requiring n...

    Authors: Eli F. Kelley, Troy J. Cross, Eric M. Snyder, Craig M. McDonald, Eric P. Hoffman and Luca Bello

    Citation: Respiratory Research 2019 20:221

    Content type: Research

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  12. Plasma metabolomics profile (PMP) in COPD has been associated with clinical characteristics, but PMP’s relationship to survival has not been reported. We determined PMP differences between patients with COPD w...

    Authors: Victor Pinto-Plata, Ciro Casanova, Miguel Divo, Yohannes Tesfaigzi, Vince Calhoun, Jing Sui, Francesca Polverino, Carmen Priolo, Hans Petersen, Juan Pablo de Torres, Jose Maria Marin, Caroline A. Owen, Rebeca Baz, Elizabeth Cordova and Bartolome Celli

    Citation: Respiratory Research 2019 20:219

    Content type: Research

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  13. Respiratory pathology is a major driver of mortality in the intensive care unit (ICU), even in the absence of a primary respiratory diagnosis. Prior work has demonstrated that a visual scoring system applied t...

    Authors: Stefanie E. Mason, Paul B. Dieffenbach, Joshua A. Englert, Angela A. Rogers, Anthony F. Massaro, Laura E. Fredenburgh, Angelica Higuera, Mayra Pinilla-Vera, Marta Vilas, Raul San Jose Estepar, George R. Washko, Rebecca M. Baron and Samuel Y. Ash

    Citation: Respiratory Research 2019 20:218

    Content type: Research

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  14. Icotinib has been widely used in patients with non-small cell lung cancer (NSCLC), and have significantly enhanced the overall survival rate of NSCLC patients. However, acquired drug resistance limits its clin...

    Authors: Yiming Yu, Maidinaimu Abudula, Chaofen Li, Zhongbo Chen, Yun Zhang and Yichen Chen

    Citation: Respiratory Research 2019 20:217

    Content type: Research

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  15. Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolu...

    Authors: Bora Sul, Lucia Flors, Joanne Cassani, Michael J. Morris, Jaques Reifman, Talissa Altes and Anders Wallqvist

    Citation: Respiratory Research 2019 20:216

    Content type: Research

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  16. Evidence on the economic impact of chronic obstructive pulmonary disease (COPD) for third-party payers and society based on large real world datasets are still scarce. Therefore, the aim of this study was to e...

    Authors: Florian Kirsch, Anja Schramm, Larissa Schwarzkopf, Johanna I. Lutter, Boglárka Szentes, Manuel Huber and Reiner Leidl

    Citation: Respiratory Research 2019 20:215

    Content type: Research

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  17. There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation be...

    Authors: Jian Liu, Yong-Quan Dong, Jie Yin, Jian Yao, Jie Shen, Guo-Jie Sheng, Kun Li, Hai-Feng Lv, Xing Fang and Wei-Fang Wu

    Citation: Respiratory Research 2019 20:161

    Content type: Research

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  18. At present, there are few methods available for monitoring respiratory diseases affecting distal airways. Bronchoscopy is the golden standard for sampling the lower airways. The recently developed method for c...

    Authors: Annelie F. Behndig, Ekaterina Mirgorodskaya, Anders Blomberg and Anna-Carin Olin

    Citation: Respiratory Research 2019 20:214

    Content type: Research

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  19. The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect...

    Authors: Ryoung-Eun Ko, Soo Jin Na, Kyungmin Huh, Gee Young Suh and Kyeongman Jeon

    Citation: Respiratory Research 2019 20:213

    Content type: Research

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  20. Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in ...

    Authors: Panayiotis Kouis, Myrofora Goutaki, Florian S. Halbeisen, Ifigeneia Gioti, Nicos Middleton, Israel Amirav, Angelo Barbato, Laura Behan, Mieke Boon, Nagehan Emiralioglu, Eric G. Haarman, Bulent Karadag, Cordula Koerner-Rettberg, Romain Lazor, Michael R. Loebinger, Bernard Maitre…

    Citation: Respiratory Research 2019 20:212

    Content type: Research

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  21. Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. Lung function measurement is a key step i...

    Authors: Eline Bonnardel, Renaud Prevel, Marilyne Campagnac, Marielle Dubreuil, Roger Marthan, Patrick Berger and Isabelle Dupin

    Citation: Respiratory Research 2019 20:211

    Content type: Research

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  22. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and asthma are associated with a variety of precipitating factors including infection. This study assessed the infective viral etiologies b...

    Authors: Fanny Wai-san Ko, Paul Kay-sheung Chan, Renee W. Y. Chan, Ka-Pang Chan, April Ip, Angela Kwok, Jenny Chun-li Ngai, So-Shan Ng, Chan Tat On and David Shu-cheong Hui

    Citation: Respiratory Research 2019 20:210

    Content type: Research

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  23. Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capaci...

    Authors: Marie-Caroline Rotty, Jean-Pierre Mallet, Carey M. Suehs, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel

    Citation: Respiratory Research 2019 20:209

    Content type: Letter to the Editor

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  24. Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Pr...

    Authors: R. James White, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Ronald J. Oudiz, Vallerie V. McLaughlin, Marius M. Hoeper, Ekkehard Grünig, Hossein-Ardeschir Ghofrani, Murali M. Chakinala, Joan A. Barberà, Christiana Blair, Jonathan Langley and Adaani E. Frost

    Citation: Respiratory Research 2019 20:208

    Content type: Research

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  25. The diagnostic yield of peripheral pulmonary lesions has significantly increased with the use of radial endobronchial ultrasound with guide sheath within the lesion. Here, we retrospectively evaluated factors ...

    Authors: Yoichi Nishii, Taro Yasuma, Kentaro Ito, Yuta Suzuki, Fumiaki Watanabe, Tetsu Kobayashi, Kota Nishihama, Corina N. D’Alessandro-Gabazza, Hajime Fujimoto, Esteban C. Gabazza, Fumihiro Asano, Osamu Taguchi and Osamu Hataji

    Citation: Respiratory Research 2019 20:207

    Content type: Research

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  26. Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe and w...

    Authors: Tuong N. Vu, Xuesong Chen, Hussein D. Foda, Gerald C. Smaldone and Nadia A. Hasaneen

    Citation: Respiratory Research 2019 20:206

    Content type: Research

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  27. Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into Type 1 alveolar epithelial cells (AT1s). In the prese...

    Authors: Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Diana Feller, Veronika Csongei, Szilard Pal, Domokos Bartis, David R. Thickett and Judit Erzsebet Pongracz

    Citation: Respiratory Research 2019 20:204

    Content type: Research

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  28. High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has nev...

    Authors: Zeina Akiki, Miora Andrianjafimasy, Farid Zerimech, Nicole Le Moual, Valérie Siroux, Orianne Dumas, Régis Matran and Rachel Nadif

    Citation: Respiratory Research 2019 20:203

    Content type: Letter to the Editor

    Published on:

  29. Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death in the world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate cancer pr...

    Authors: Shengjie Chen, Tianyi Gu, Ziwen Lu, Lipeng Qiu, Guoliang Xiao, Xiaozhong Zhu, Feng Li, Hui Yu, Gang Li and Hanqing Liu

    Citation: Respiratory Research 2019 20:202

    Content type: Research

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  30. Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for CO...

    Authors: Xiaobo Liang, Xiang He, Yin Li, Junyi Wang, Dehong Wu, Xiefang Yuan, Xiaoyun Wang and Guoping Li

    Citation: Respiratory Research 2019 20:201

    Content type: Research

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  31. Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronc...

    Authors: Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers and Estelle Cormet-Boyaka

    Citation: Respiratory Research 2019 20:200

    Content type: Letter to the Editor

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  32. Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was develo...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Saher Burhan Shaker, Jesper Rømhild Davidsen, Janelle Yorke, Ole Hilberg and Elisabeth Bendstrup

    Citation: Respiratory Research 2019 20:199

    Content type: Research

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  33. There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations ...

    Authors: Cecilia Mouronte-Roibás, Virginia Leiro-Fernández, Alberto Ruano-Raviña, Cristina Ramos-Hernández, Pedro Casado-Rey, Maribel Botana-Rial, Esmeralda García-Rodríguez and Alberto Fernández-Villar

    Citation: Respiratory Research 2019 20:198

    Content type: Research

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  34. Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness i...

    Authors: David I. Kasahara, Jeremy E. Wilkinson, Youngji Cho, Aline P. Cardoso, Curtis Huttenhower and Stephanie A. Shore

    Citation: Respiratory Research 2019 20:197

    Content type: Research

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  35. The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

    Authors: Guoqing Wang, Howard H. Lou, Jacqueline Salit, Philip L. Leopold, Sharon Driscoll, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:196

    Content type: Research

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  36. Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

    Authors: Steven J. Pascoe, Alberto Papi, Dawn Midwinter, Sally Lettis and Neil Barnes

    Citation: Respiratory Research 2019 20:195

    Content type: Research

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  37. The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

    Authors: Zhongwei Wen, Rongfang Jiang, Ying Huang, Zhineng Wen, Dong Rui, Xiaoxiao Liao and Zhougui Ling

    Citation: Respiratory Research 2019 20:194

    Content type: Research

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  38. It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...

    Authors: Young-Jin Choi, Ju-Hee Jeon and Jae-Won Oh

    Citation: Respiratory Research 2019 20:193

    Content type: Research

    Published on:

  39. Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual an...

    Authors: Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin and Sheng-xing Zheng

    Citation: Respiratory Research 2019 20:192

    Content type: Research

    Published on:

  40. Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this...

    Authors: Maeva Zysman, Pierre-Régis Burgel, Isabelle Court-Fortune, Graziella Brinchault-Rabin, Pascale Nesme-Meyer, Pascale Surpas, Gaetan Deslée, Thierry Perez, Olivier Le Rouzic, Gilles Jebrak, Pascal Chanez, Jean-Louis Paillasseur, Denis Caillaud and Nicolas Roche

    Citation: Respiratory Research 2019 20:191

    Content type: Letter to the Editor

    Published on:

  41. Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response pl...

    Authors: Venkataramana K. Sidhaye, Janet T. Holbrook, Alyce Burke, Kuladeep R. Sudini, Sanjay Sethi, Gerard J. Criner, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Rajesh Thimmulappa, Robert A. Wise and Shyam Biswal

    Citation: Respiratory Research 2019 20:190

    Content type: Research

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  42. The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be info...

    Authors: Nicolas Roche, Anestis Antoniadis, David Hess, Pei Zhi Li, Eric Kelkel, Sylvie Leroy, Christophe Pison, Pierre-Régis Burgel and Bernard Aguilaniu

    Citation: Respiratory Research 2019 20:189

    Content type: Research

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  43. Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial d...

    Authors: Haili Sun, Fang Fang, Kun Li, Huina Zhang, Ming Zhang, Lichuan Zhang, Juan Li, Yanwen Qin and Yongxiang Wei

    Citation: Respiratory Research 2019 20:188

    Content type: Research

    Published on:

  44. Acute pulmonary embolism (APE) is one of the leading causes of death in cardiovascular disease. The 30-day mortality can still be 1.7–15% in non-high-risk APE patients. Some non-high-risk patients can progress...

    Authors: Dong Jia, Xue-lian Li, Qin Zhang, Gang Hou, Xiao-ming Zhou and Jian Kang

    Citation: Respiratory Research 2019 20:187

    Content type: Research

    Published on:

  45. An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...

    Authors: Stefan Andreas, Christian Röver, Judith Heinz, Sebastian Straube, Henrik Watz and Tim Friede

    Citation: Respiratory Research 2019 20:186

    Content type: Research

    Published on:

  46. We previously reported cryobiopsy (Cryo) with endobronchial ultrasonography-guide sheath (EBUS-GS) for peripheral pulmonary lesions (PPLs) provides significantly larger tissues than transbronchial biopsy (TBB)...

    Authors: Ken Arimura, Mitsuko Kondo, Yoji Nagashima, Masato Kanzaki, Fumi Kobayashi, Kiyoshi Takeyama, Jun Tamaoki and Etsuko Tagaya

    Citation: Respiratory Research 2019 20:185

    Content type: Research

    Published on:

  47. Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for seve...

    Authors: K. D. Hebert, N. Mclaughlin, Zhe Zhang, A. Cipriani, J. F. Alcorn and D. A. Pociask

    Citation: Respiratory Research 2019 20:184

    Content type: Research

    Published on:

  48. Asthma is a heterogeneous lung disease, usually characterised by chronic airway inflammation. Although evidence-based treatments are available in most countries, asthma control remains suboptimal, and asthma-r...

    Authors: Jaya Muneswarao, Mohamed Azmi Hassali, Baharudin Ibrahim, Bandana Saini, Irfhan Ali Hyder Ali and Ashutosh Kumar Verma

    Citation: Respiratory Research 2019 20:183

    Content type: Commentary

    Published on:

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