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  1. Targeted lung cancer screening is effective in reducing mortality by upwards of twenty percent. However, screening is not universally available and uptake is variable and socially patterned. Understanding scre...

    Authors: Debbie Cavers, Mia Nelson, Jasmin Rostron, Kathryn A. Robb, Lynsey R. Brown, Christine Campbell, Ahsan R. Akram, Graeme Dickie, Melanie Mackean, Edwin J. R. van Beek, Frank Sullivan, Robert J. Steele, Aileen R. Neilson and David Weller
    Citation: Respiratory Research 2022 23:374
  2. To investigate the prognostic value of quantitative analysis of CT among patients with idiopathic pulmonary fibrosis (IPF) by quantifying the fibrosis extent and to attempt to provide precise medium-long term ...

    Authors: Kaifeng Du, Yichun Zhu, Ruolin Mao, Yubei Qu, Bo Cui, Yuan Ma, Xin Zhang and Zhihong Chen
    Citation: Respiratory Research 2022 23:372
  3. There is still insufficient knowledge with regard to the potential involvement of mast cells (MCs) and their mediators in the pathology of coronavirus disease-2019 (COVID-19). Therefore, our study aimed to inv...

    Authors: Andrey V. Budnevsky, Sergey N. Avdeev, Djuro Kosanovic, Victoria V. Shishkina, Andrey A. Filin, Dmitry I. Esaulenko, Evgeniy S. Ovsyannikov, Tatiana V. Samoylenko, Alexander N. Redkin, Olga A. Suvorova and Inna M. Perveeva
    Citation: Respiratory Research 2022 23:371
  4. Screening decreases mortality among lung cancer patients but is not widely implemented, thus there is an unmet need for an easily accessible non-invasive method to enable early diagnosis. Particles in exhaled ...

    Authors: Jesper Andreasson, Embla Bodén, Mohammed Fakhro, Camilla von Wachter, Franziska Olm, Malin Malmsjö, Oskar Hallgren and Sandra Lindstedt
    Citation: Respiratory Research 2022 23:369
  5. Hypersensitivity pneumonitis (HP) is a type of interstitial lung disease (ILD) with a variable disease course and prognosis ranging from inflammatory and self-limiting to irreversible and progressive pulmonary...

    Authors: Thomas Skovhus Prior, Julia Wälscher, Benjamin Gross, Elisabeth Bendstrup and Michael Kreuter
    Citation: Respiratory Research 2022 23:368
  6. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, whose pathogenetic complexity was strongly associated with aging/smoking and poorly understood.

    Authors: Qiqing Huang, Yuanyuan Wang, Lili Zhang, Wei Qian, Shaoran Shen, Jingshen Wang, Shuangshuang Wu, Wei Xu, Bo Chen, Mingyan Lin and Jianqing Wu
    Citation: Respiratory Research 2022 23:367
  7. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating respiratory disorder with high rates of mortality and morbidity, but the detailed underlying mechanisms of ALI/ARDS remain larg...

    Authors: Qi Jia, Yiyi Yang, Xiangdong Chen, Shanglong Yao and Zhiqiang Hu
    Citation: Respiratory Research 2022 23:366
  8. Bronchiectasis and bronchiolitis are differential diagnoses of asthma; moreover, they are factors associated with worse asthma control.

    Authors: Natsuko Nomura, Hisako Matsumoto, Akihito Yokoyama, Yoshihiro Nishimura, Koichiro Asano, Akio Niimi, Yuji Tohda, Norihiro Harada, Hiroyuki Nagase, Makoto Nagata, Hiromasa Inoue, Mitsuko Kondo, Takahiko Horiguchi, Nobuaki Miyahara, Nobuyuki Hizawa, Masayuki Hojo…
    Citation: Respiratory Research 2022 23:365
  9. β2-agonists provide necessary bronchodilatory action, are recommended by existing clinical practice guidelines and are widely prescribed for patients with these conditions. We examined the risk of all-cause mo...

    Authors: Joseph Emil Amegadzie, John-Michael Gamble, Jamie Farrell and Zhiwei Gao
    Citation: Respiratory Research 2022 23:364
  10. Bronchiectasis is characterized by neutrophilic inflammation and frequent exacerbations often associated with infections. Lipid mediators play critical roles in the inflammatory response, and the balance betwe...

    Authors: Leonardo Terranova, Patrizia Risé, Andrea Gramegna, Christian Pinna, Carlo Agostoni, Marie-Louise Syrén, Stefano Turolo, Paola Marchisio, Francesco Amati, Stefano Aliberti, Angelo Sala and Francesco Blasi
    Citation: Respiratory Research 2022 23:363
  11. Little is known about the relationship between N6-methyladenosine (m6A)-related genes and tumor immune microenvironment (TIME) in non-small cell lung cancer (NSCLC). It is unclear which m6A regulators are esse...

    Authors: Zhuoyu Gu, Yang Yang, Qian Ma, Hui Wang, Song Zhao, Yu Qi and Yixin Li
    Citation: Respiratory Research 2022 23:362
  12. Respiratory self-care places considerable demands on patients with chronic airways disease (AD), as they must obtain, understand and apply information required to follow their complex treatment plans. If clini...

    Authors: Iraj Poureslami, J. Mark FitzGerald, Noah Tregobov, Roger S. Goldstein, M. Diane Lougheed and Samir Gupta
    Citation: Respiratory Research 2022 23:361
  13. Lung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between L...

    Authors: Daniele Guerino Biasucci, Barbara Loi, Roberta Centorrino, Roberto Raschetti, Marco Piastra, Luca Pisapia, Ludovica Maria Consalvo, Anselmo Caricato, Domenico Luca Grieco, Giorgio Conti, Massimo Antonelli and Daniele De Luca
    Citation: Respiratory Research 2022 23:360
  14. Primary ciliary dyskinesia (PCD) is a genetic disorder characterized by recurrent airway infection and inflammation. There is no cure for PCD and to date there are no specific treatments available. Neutrophils...

    Authors: Marfa Blanter, Maaike Cockx, Liesel Wittebols, Sara Abouelasrar Salama, Mirre De Bondt, Nele Berghmans, Noëmie Pörtner, Lotte Vanbrabant, Natalie Lorent, Mieke Gouwy, Mieke Boon and Sofie Struyf
    Citation: Respiratory Research 2022 23:359
  15. Rapid magnetic stimulation (RMS) of the phrenic nerves may serve to attenuate diaphragm atrophy during mechanical ventilation. With different coil shapes and stimulation location, inspiratory responses and sid...

    Authors: Kyle G. P. J. M. Boyle, Philipp A. Eichenberger, Patrick Schön and Christina M. Spengler
    Citation: Respiratory Research 2022 23:357
  16. To study the regulatory effect of Long non-coding RNA (LncRNA) HOX transcript antisense RNA (HOTAIR) on pulmonary vascular endothelial cell (HPVEC) apoptosis and determine whether the HOTAIR facilitate HPVEC a...

    Authors: Zhongshang Dai, Xiangming Liu, Huihui Zeng and Yan Chen
    Citation: Respiratory Research 2022 23:356
  17. Pulmonary arterial hypertension (PAH) is a progressive disease characterized by high mean pulmonary arterial pressure (≥ 20 mmHg) and remodeling of the vascular arteries. Approved therapies improve symptoms an...

    Authors: Raymond L. Benza, Veronica Franco, Mandar A. Aras, Leslie Spikes, Daniel Grinnan and Carol Satler
    Citation: Respiratory Research 2022 23:355
  18. Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto...

    Authors: Rajani Ghale, Natasha Spottiswoode, Mark S. Anderson, Anthea Mitchell, Grace Wang, Carolyn S. Calfee, Joseph L. DeRisi and Charles R. Langelier
    Citation: Respiratory Research 2022 23:354
  19. Pulmonary hypertension (PH) is characterized by progressive pulmonary arterial remodelling, associated with different severities of inflammation and altered immune processes. Disulfiram eliminates the formatio...

    Authors: Shunlian Hu, Lu Wang, Yahan Xu, Fajiu Li and Tao Wang
    Citation: Respiratory Research 2022 23:353
  20. Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded wit...

    Authors: Marc Miravitlles, Alice M. Turner, María Torres-Duran, Hanan Tanash, Carlota Rodríguez-García, José Luis López-Campos, Jan Chlumsky, Catarina Guimaraes, Juan Luis Rodríguez-Hermosa, Angelo Corsico, Cristina Martinez-González, José María Hernández-Pérez, Ana Bustamante, David G. Parr, Francisco Casas-Maldonado, Ana Hecimovic…
    Citation: Respiratory Research 2022 23:352
  21. Ischaemia–reperfusion injury (IRI) encompasses the deleterious effects on cellular function and survival that result from the restoration of organ perfusion. Despite their unique tolerance to ischaemia and hyp...

    Authors: Dimitrios Vlastos, Mohamed Zeinah, George Ninkovic-Hall, Stefanos Vlachos, Agni Salem, Athanasios Asonitis, Hemangi Chavan, Lazaros Kalampalikis, Abdullah Al Shammari, José María Alvarez Gallesio, Aina Pons, Ioanna Andreadou and Ignatios Ikonomidis
    Citation: Respiratory Research 2022 23:351
  22. Authors: K. C. Gribben, A. B. Wyss, J. A. Poole, P. A. Farazi, C. Wichman, M. Richards-Barber, L. E. Beane Freeman, P. K. Henneberger, D. M. Umbach, S. J. London and T. D. LeVan
    Citation: Respiratory Research 2022 23:350

    The original article was published in Respiratory Research 2022 23:305

  23. Despite causing increased morbidity and mortality, pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) patients (COPD-PH) lacks treatment, due to incomplete understanding of its pathoge...

    Authors: Khushboo Goel, Nicholas Egersdorf, Amar Gill, Danting Cao, Scott D. Collum, Soma S. Jyothula, Howard J. Huang, Maor Sauler, Patty J. Lee, Susan Majka, Harry Karmouty-Quintana and Irina Petrache
    Citation: Respiratory Research 2022 23:349
  24. Associations between birth weight (BW) and adult lung function have been inconsistent and limited to early adulthood. We aimed to study this association in two population-based cohorts and explore if BW, adjus...

    Authors: Aleksandra Sakic, Magnus Ekström, Shantanu Sharma and Peter M. Nilsson
    Citation: Respiratory Research 2022 23:348
  25. Persistent airflow limitation and dyspnoea may reduce chronic obstructive pulmonary disease (COPD) patients exercise capacity and physical activity, undermining their physical status and quality of life. Long-...

    Authors: Marc Miravitlles, Juan Luís García-Rivero, Xavier Ribera, Jordi Galera, Alejandra García, Rosa Palomino and Xavier Pomares
    Citation: Respiratory Research 2022 23:347
  26. A lack of clear trial evidence often hampers clinical decision-making during support of the preterm lung at birth. Protein biomarkers have been used to define acute lung injury phenotypes and improve patient s...

    Authors: Prue M. Pereira-Fantini, Kristin Ferguson, Karen McCall, Regina Oakley, Elizabeth Perkins, Sean Byars, Nicholas Williamson, Shuai Nie and David G. Tingay
    Citation: Respiratory Research 2022 23:346
  27. The application of clinical mNGS for diagnosing respiratory infections improves etiology diagnosis, however at the same time, it brings new challenges as an unbiased sequencing method informing all identified ...

    Authors: Qing Miao, Tianzhu Liang, Na Pei, Chunjiao Liu, Jue Pan, Na Li, Qingqing Wang, Yanqiong Chen, Yu Chen, Yuyan Ma, Wenting Jin, Yao Zhang, Yi Su, Yumeng Yao, Yingnan Huang, Chunmei Zhou…
    Citation: Respiratory Research 2022 23:345
  28. Trimethylamine N-oxide (TMAO), the gut microbiota-dependent metabolite, is a potential biomarker in several cardiovascular diseases. However, no study has investigated its value in pulmonary hypertension (PH)....

    Authors: Yicheng Yang, Beilan Yang, Xin Li, Lin Xue, Bingyang Liu, Yanru Liang, Zhihui Zhao, Qin Luo, Zhihong Liu, Qixian Zeng and Changming Xiong
    Citation: Respiratory Research 2022 23:344
  29. SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently, various markers reflect this wide spectrum of disease pr...

    Authors: Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner and Tobias Welte
    Citation: Respiratory Research 2022 23:343
  30. At the time of the SARS-CoV-2 emergence, asthma patients were initially considered vulnerable because respiratory viruses, especially influenza, are associated with asthma exacerbations, increased risk of hosp...

    Authors: Axelle Dupont, Camille Couffignal, Camila Arias, Kankoe Salah, Mathilde Phillips-Houlbraq, Mathilde Le Brun and Camille Taillé
    Citation: Respiratory Research 2022 23:342
  31. Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood. The study objective is to det...

    Authors: Michelle A. Stubbs, Vanessa L. Clark, Peter G. Gibson, Janelle Yorke and Vanessa M. McDonald
    Citation: Respiratory Research 2022 23:341
  32. Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. ...

    Authors: Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. Huntington, Monique E. De Paepe and Phyllis A. Dennery
    Citation: Respiratory Research 2022 23:340
  33. Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver and lung disease. The characterization at structural level of novel pathogenic SERPINA...

    Authors: Angel Gonzalez, Irene Belmonte, Alexa Nuñez, Georgina Farago, Miriam Barrecheguren, Mònica Pons, Gerard Orriols, Pablo Gabriel-Medina, Francisco Rodríguez-Frías, Marc Miravitlles and Cristina Esquinas
    Citation: Respiratory Research 2022 23:339
  34. PM2.5 exposure is associated with lung adenocarcinoma (LUAD), but the mechanism is unclear. The lack of understanding impedes our effort on prevention. This study examined a possible mechanism of lung cancer caus...

    Authors: Tengteng Zhu, Yangyang Li, Tienan Feng, Yuqing Yang, Kai Zhang, Jing Gao, Xiaowei Quan, Ying Qian, Herbert Yu and Biyun Qian
    Citation: Respiratory Research 2022 23:338
  35. Airway instillation of bleomycin (BLM) in mice is a widely used, yet challenging, model for acute lung injury (ALI) with high variability in treatment scheme and animal outcomes among investigators. Whether th...

    Authors: Young me Yoon, Cara L. Hrusch, Na Fei, Gabriel M. Barrón, Kathleen A. M. Mills, Maile K. Hollinger, Tania E. Velez, Vanessa A. Leone, Eugene B. Chang and Anne I. Sperling
    Citation: Respiratory Research 2022 23:337
  36. The global initiative for chronic obstructive lung disease (GOLD) 2020 emphasizes that there is only a weak correlation between FEV1, symptoms and impairment of the health status of patients with chronic obstruct...

    Authors: Cathelijne M. van Zelst, Lucas M. A. Goossens, Jan A. Witte, Gert-Jan Braunstahl, Rudi W. Hendriks, Maureen P. M. H. Rutten-van Molken and Johannes C. C. M. in’t Veen
    Citation: Respiratory Research 2022 23:336
  37. Studies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age group are still scarce, and few include bronchial tissue analysis.

    Authors: Miriam Cardoso Neves Eller, Karina Pierantozzi Vergani, Beatriz Mangueira Saraiva-Romanholo, Natália de Souza Xavier Costa, Jôse Mára de Brito, Leila Antonangelo, Caroline Silvério Faria, Joaquim Carlos Rodrigues and Thais Mauad
    Citation: Respiratory Research 2022 23:335
  38. Antifibrotic therapy can slow disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, the prognostic biomarkers for DP in patients with IPF receiving antifibrotic therapy have n...

    Authors: Myeong Geun Choi, Sun Mi Choi, Jae Ha Lee, Joong-Yub Kim and Jin Woo Song
    Citation: Respiratory Research 2022 23:334
  39. The nasal cannula is considered a trusted and effective means of administering low-flow oxygen and is widely used for neonates and infants requiring oxygen therapy, despite an understanding that oxygen concent...

    Authors: Mozhgan Sabz, Scott Tavernini, Kineshta Pillay, Cole Christianson, Michelle Noga, Warren H. Finlay, Hossein Rouhani and Andrew R. Martin
    Citation: Respiratory Research 2022 23:333
  40. Diffuse interstitial lung diseases (ILD) constitute a heterogeneous group of conditions with complex etiological diagnoses requiring a multidisciplinary approach. Much is still unknown about them, particularly...

    Authors: Ségolene Carlier, Mouhamad Nasser, Emmanuel Fort, Céline Lamouroux, Salim Si-Mohamed, Lara Chalabreysse, Jean-Michel Maury, Rémi Diesler, Vincent Cottin and Barbara Charbotel
    Citation: Respiratory Research 2022 23:332
  41. Pulmonary hypertension (PH) is a frequent complication in COPD and it is associated with decreased exercise capacity and poor prognosis. We hypothesized that even in COPD patients without significant PH at res...

    Authors: Teresa Sassmann, Philipp Douschan, Vasile Foris, Natascha Tröster, Katarina Zeder, Luka Brcic, Adrienn Tornyos, Gerhard Bachmaier, Michael Fuchsjäger, Horst Olschewski and Gabor Kovacs
    Citation: Respiratory Research 2022 23:331
  42. Use of long-term tobramycin inhalation solution (TIS) has been shown beneficial in cystic fibrosis (CF) and earlier findings also suggest a benefit in non-CF bronchiectasis. We investigated the efficacy and sa...

    Authors: Lotte C. Terpstra, Josje Altenburg, Inez Bronsveld, Martijn D. de Kruif, Yvonne Berk, Dominic Snijders, Wouter Rozemeijer, Harry G. M. Heijerman and Wim G. Boersma
    Citation: Respiratory Research 2022 23:330
  43. High-flow nasal oxygen therapy (HFNC) may be an attractive first-line ventilatory support in COVID-19 patients. However, HNFC use for the management of COVID-19 patients and risk factors for HFNC failure remai...

    Authors: Zakaria Ait Hamou, Nathan Levy, Julien Charpentier, Jean-Paul Mira, Matthieu Jamme and Mathieu Jozwiak
    Citation: Respiratory Research 2022 23:329
  44. Bronchiectasis is a highly heterogeneous chronic airway disease with marked geographic and ethnic variations. Most influential cohort studies to date have been performed in Europe and USA, which serve as the e...

    Authors: Yong-Hua Gao, Hai-Wen Lu, Bei Mao, Wei-Jie Guan, Yuan-Lin Song, Yuan-Yuan Li, Dao-Xin Wang, Bin Wang, Hong-Yan Gu, Wen Li, Hong Luo, Ling-Wei Wang, Fan Li, Feng-Xia Guo, Min Zhang, Zhi-Jun Jie…
    Citation: Respiratory Research 2022 23:328
  45. Acute respiratory distress syndrome (ARDS) is one of the most severe complications of SARS-CoV-2 infection. Non-Invasive Respiratory Support (NRS) as Continuous Positive Airway Pressure (CPAP) and/or Non-Invas...

    Authors: Riccardo Nevola, Antonio Russo, Samuel Scuotto, Simona Imbriani, Concetta Aprea, Marianna Abitabile, Domenico Beccia, Chiara Brin, Caterina Carusone, Francesca Cinone, Giovanna Cirigliano, Sara Colantuoni, Domenico Cozzolino, Giovanna Cuomo, Micol Del Core, Klodian Gjeloshi…
    Citation: Respiratory Research 2022 23:327
  46. Bacterial pneumonia is a major risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Pseudomonas aeruginosa (PA), an opportunistic pathogen with an increasing resistance acquired...

    Authors: Nagaraja Nagre, Gregory Nicholson, Xiaofei Cong, Janette Lockett, Andrew C. Pearson, Vincent Chan, Woong-Ki Kim, K. Yaragudri Vinod and John D. Catravas
    Citation: Respiratory Research 2022 23:326
  47. Without aggressive treatment, pulmonary arterial hypertension (PAH) has a 5-year mortality of approximately 40%. A patient’s response to vasodilators at diagnosis impacts the therapeutic options and prognosis....

    Authors: Tilo Winkler, Puja Kohli, Vanessa J. Kelly, Ekaterina G. Kehl, Alison S. Witkin, Josanna M. Rodriguez-Lopez, Kathryn A. Hibbert, Mamary T. Kone, David M. Systrom, Aaron B. Waxman, Jose G. Venegas, Richard N. Channick and R. Scott Harris
    Citation: Respiratory Research 2022 23:325

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