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  1. Content type: Research

    Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and...

    Authors: Esther P.W.A. Talboom-Kamp, Marije S. Holstege, Niels H. Chavannes and Marise J. Kasteleyn

    Citation: Respiratory Research 2019 20:146

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  2. Content type: Review

    The risk and prevalence of chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis (RA) is still obscure. The current study was aimed to systematically review and meta-analyse the risk ratio (RR) ...

    Authors: Yubo Ma, Hui Tong, Xu Zhang, Mengmeng Wang, Jiajia Yang, Meng Wu, Renfang Han, Mengya Chen, Xingxing Hu, Yaping Yuan, Guixia Pan, Yanfeng Zou, Shengqian Xu and Faming Pan

    Citation: Respiratory Research 2019 20:144

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  3. Content type: Research

    Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate t...

    Authors: Ying Duan, Gaowen Liu, Yao Sun, Jiamin Wu, Zichao Xiong, Tianbo Jin and Mingwei Chen

    Citation: Respiratory Research 2019 20:143

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  4. Content type: Review

    There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1...

    Authors: Dave Singh, Anthony D. D’Urzo, James F. Donohue and Edward M. Kerwin

    Citation: Respiratory Research 2019 20:141

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  5. Content type: Research

    Bronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenc...

    Authors: Juergen Hetzel, Ralf Eberhardt, Christoph Petermann, Wolfgang Gesierich, Kaid Darwiche, Lars Hagmeyer, Rainer Muche, Michael Kreuter, Richard Lewis, Ahmed Ehab, Michael Boeckeler and Maik Haentschel

    Citation: Respiratory Research 2019 20:140

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  6. Content type: Research

    Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The s...

    Authors: Kingsley Katleho Mokoena, Crystal Jane Ethan, Yan Yu, Karabo Shale and Feng Liu

    Citation: Respiratory Research 2019 20:139

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  7. Content type: Research

    Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized. Our investigation of 28,727 chest X-rays obtained from annual health...

    Authors: Akira Saito, Yukichika Hakamata, Yukiko Yamada, Mitsuhiro Sunohara, Megumi Tarui, Yoko Murano, Akihisa Mitani, Kimie Tanaka, Takahide Nagase and Shintaro Yanagimoto

    Citation: Respiratory Research 2019 20:138

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  8. Content type: Letter to the Editor

    The severity of Hereditary Hemorrhagic Telangiectasia (HHT) disease is generally related to vascular visceral involvement represented by arteriovenous malformations (AVMs). Pulmonary function tests (PFTs) rema...

    Authors: Carole de Picciotto, Mostafa El Hajjam, Carma Karam, Thierry Chinet and Marcel Bonay

    Citation: Respiratory Research 2019 20:137

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  9. Content type: Research

    The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors fo...

    Authors: Yunjoo Im, Hye Yun Park, Sumin Shin, Sun Hye Shin, Hyun Lee, Joong Hyun Ahn, Insuk Sohn, Jong Ho Cho, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Ho Yun Lee and Jhingook Kim

    Citation: Respiratory Research 2019 20:136

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  10. Content type: Research

    Smoking is a major risk factor for COPD and may impact the efficacy of COPD treatments; however, a large proportion of COPD patients continue to smoke following diagnosis.

    Authors: Donald P. Tashkin, Thomas Goodin, Alyssa Bowling, Barry Price, Ayca Ozol-Godfrey, Sanjay Sharma and Shahin Sanjar

    Citation: Respiratory Research 2019 20:135

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  11. Content type: Research

    Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical cha...

    Authors: F. Bianco, F. Ricci, C. Catozzi, X. Murgia, M. Schlun, A. Bucholski, U. Hetzer, S. Bonelli, M. Lombardini, E. Pasini, M. Nutini, M. Pertile, S. Minocchieri, M. Simonato, B. Rosa, G. Pieraccini…

    Citation: Respiratory Research 2019 20:134

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  12. Content type: Research

    Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung...

    Authors: Francesca Polverino, Bao Lu, Joselyn Rojas Quintero, Sara O. Vargas, Avignat S. Patel, Caroline A. Owen, Norma P. Gerard, Craig Gerard and Manuela Cernadas

    Citation: Respiratory Research 2019 20:133

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  13. Content type: Research

    Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who are unable to administer medications efficiently with conventional inhalers may benefit from the use of a n...

    Authors: Brian R. Leaker, Dave Singh, Grant C. Nicholson, Blanka Hezelova, Thomas Goodin, Ayca Ozol-Godfrey, Gerald Galluppi and Peter J. Barnes

    Citation: Respiratory Research 2019 20:132

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  14. Content type: Research

    Patients with acute lung injury (ALI) have increased levels of pro-inflammatory mediators, which impair endothelial progenitor cell (EPC) function. Increasing the number of EPC and alleviating EPC dysfunction ...

    Authors: Nana Yang, Hua Tian, Enxin Zhan, Lei Zhai, Peng Jiao, Shutong Yao, Guohua Lu, Qingjie Mu, Juan Wang, Aihua Zhao, Yadong Zhou and Shucun Qin

    Citation: Respiratory Research 2019 20:131

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  15. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce excessive extracellular matrix accumula...

    Authors: Arnoldo Aquino-Gálvez, Georgina González-Ávila, Laura Lorena Jiménez-Sánchez, Héctor Aquiles Maldonado-Martínez, José Cisneros, Fernanda Toscano-Marquez, Manuel Castillejos-López, Luz María Torres-Espíndola, Rafael Velázquez-Cruz, Víctor Hugo Olivera Rodríguez, Edgar Flores-Soto, Héctor Solís-Chagoyán, Carlos Cabello, Joaquín Zúñiga and Yair Romero

    Citation: Respiratory Research 2019 20:130

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  16. Content type: Research

    Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its ant...

    Authors: Ari Jon Arason, Jon Petur Joelsson, Bryndis Valdimarsdottir, Snaevar Sigurdsson, Alexander Gudjonsson, Skarphedinn Halldorsson, Freyr Johannsson, Ottar Rolfsson, Fredrik Lehmann, Saevar Ingthorsson, Paulina Cherek, Gudmundur H. Gudmundsson, Fridrik R. Gardarsson, Clive P. Page, Olafur Baldursson, Thorarinn Gudjonsson…

    Citation: Respiratory Research 2019 20:129

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  17. Content type: Research

    Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis...

    Authors: Michael E. O’Brien, Divay Chandra, Robert C. Wilson, Chad M. Karoleski, Carl R. Fuhrman, Joseph K. Leader, Jiantao Pu, Yingze Zhang, Alison Morris, Seyed Nouraie, Jessica Bon, Zsolt Urban and Frank C. Sciurba

    Citation: Respiratory Research 2019 20:128

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  18. Content type: Research

    Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF...

    Authors: Estrella Fernández-Fabrellas, María Molina-Molina, Joan B. Soriano, José Antonio Rodríguez Portal, Julio Ancochea, Claudia Valenzuela and Antoni Xaubet

    Citation: Respiratory Research 2019 20:127

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  19. Content type: Research

    Viral respiratory infection (VRI) is a common contraindication to elective surgery. Asymptomatic shedding among pediatric surgery patients (PSPs) could potentially lead to progression of symptomatic diseases a...

    Authors: Dan Zhang, Xiuyu Lou, Hao Yan, Junhang Pan, Haiyan Mao, Hongfeng Tang, Yan Shu, Yun Zhao, Lei Liu, Junping Li, Dong Chen, Yanjun Zhang and Xuejun Ma

    Citation: Respiratory Research 2019 20:126

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  20. Content type: Research

    Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possib...

    Authors: Marcell Szily, Adam D. Tarnoki, David L. Tarnoki, Daniel T. Kovacs, Bianka Forgo, Jooyeon Lee, Eunae Kim, Joohon Sung, Laszlo Kunos, Martina Meszaros, Veronika Muller and Andras Bikov

    Citation: Respiratory Research 2019 20:125

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  21. Content type: Research

    Allergic mechanisms related to environmental and occupational exposure have been suggested to contribute to the development of chronic obstructive pulmonary disease (COPD).

    Authors: Matthieu Veil-Picard, Thibaud Soumagne, Rechana Vongthilath, Isabella Annesi-Maesano, Alicia Guillien, Lucie Laurent, Pascal Andujar, Nicolas Roche, Stephane Jouneau, Benoit Cypriani, Jean-Jacques Laplante, Bruno Degano and Jean-Charles Dalphin

    Citation: Respiratory Research 2019 20:124

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  22. Content type: Research

    Right ventricular (RV) angiogenesis has been associated with adaptive myocardial remodeling in pulmonary hypertension (PH), though molecular regulators are poorly defined. Endothelial cell VEGFR-2 is considere...

    Authors: Grace L. Peloquin, Laura Johnston, Mahendra Damarla, Rachel L. Damico, Paul M. Hassoun and Todd M. Kolb

    Citation: Respiratory Research 2019 20:123

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  23. Content type: Research

    Previous studies have found associations between asthma morbidity and air pollution especially in young population, (PLoS One 12:e0180522, 2017; Can J Public Health 103:4-8, 2012; Environ Health Perspect 118:4...

    Authors: Feifei Liu, Fangfang Qu, Huiran Zhang, Lingshan Chao, Rongqin Li, Fengxue Yu, Jitao Guan and Xixin Yan

    Citation: Respiratory Research 2019 20:122

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  24. Content type: Research

    Abnormal sympathetic hyperactivity has been shown to lead to pulmonary arterial hypertension (PAH) deterioration. The purpose of this study was to examine whether the transection of the cervical sympathetic tr...

    Authors: Yongpeng Zhao, Rui Xiang, Xin Peng, Qian Dong, Dan Li, Guiquan Yu, Lei Xiao, Shu Qin and Wei Huang

    Citation: Respiratory Research 2019 20:121

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  25. Content type: Research

    A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease ...

    Authors: Junling Zhao, Miao Li, Zhihua Wang, Jinkun Chen, Jianping Zhao, Yongjian Xu, Xiang Wei, Jianmao Wang and Jungang Xie

    Citation: Respiratory Research 2019 20:120

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  26. Content type: Research

    Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1...

    Authors: Jin Jin, Shinsaku Togo, Kotaro Kadoya, Miniwan Tulafu, Yukiko Namba, Moe Iwai, Junko Watanabe, Kumi Nagahama, Takahiro Okabe, Moulid Hidayat, Yuzo Kodama, Hideya Kitamura, Takashi Ogura, Norikazu Kitamura, Kazuho Ikeo, Shinichi Sasaki…

    Citation: Respiratory Research 2019 20:119

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  27. Content type: Research

    The mechanisms of lung injury in acute respiratory distress syndrome (ARDS) are not well understood.Piezo1 was recently identified as a mechanotransduction protein. The present study found the expression of Pi...

    Authors: Guo-Peng Liang, Jing Xu, Li-li Cao, Yi-Hua Zeng, Bai-Xu Chen, Jing Yang, Zhong-Wei Zhang and Yan Kang

    Citation: Respiratory Research 2019 20:118

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  28. Content type: Research

    Connective tissue disease associated with interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD) alone have same pathological and imaging backgrounds. However, the differences between lung can...

    Authors: Won-Il Choi, Dong Yoon Lee, Hyun-Gi Choi and Choong Won Lee

    Citation: Respiratory Research 2019 20:117

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  29. Content type: Research

    Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung up...

    Authors: Monica P. Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M. D’Armiento and Lynne L. Johnson

    Citation: Respiratory Research 2019 20:116

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  30. Content type: Study protocol

    Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...

    Authors: James E. Gern, Daniel J. Jackson, Robert F. Lemanske Jr, Christine M. Seroogy, Umberto Tachinardi, Mark Craven, Stephen Y. Hwang, Carol M. Hamilton, Wayne Huggins, George T. O’Connor, Diane R. Gold, Rachel Miller, Meyer Kattan, Christine C. Johnson, Dennis Ownby, Edward M. Zoratti…

    Citation: Respiratory Research 2019 20:115

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  31. Content type: Research

    Chronic obstructive pulmonary disease (COPD) frequent exacerbators (FE) suffer increased morbidity and mortality compared to infrequent exacerbators (IE). The association between the oral and sputum microbiota...

    Authors: Alexa A. Pragman, Katherine A. Knutson, Trevor J. Gould, Richard E. Isaacson, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2019 20:114

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  32. Content type: Research

    The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly und...

    Authors: Li Long, Hongmei Yao, Jing Tian, Wei Luo, Xinxin Yu, Fang Yi, Qiaoli Chen, Jiaxing Xie, Nanshan Zhong, Kian Fan Chung and Kefang Lai

    Citation: Respiratory Research 2019 20:112

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  33. Content type: Research

    Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PA...

    Authors: Annette D. Rieg, Nina A. Bünting, Christian Cranen, Said Suleiman, Jan W. Spillner, Heike Schnöring, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Paul W. Manley, Gereon Schälte, Rolf Rossaint, Stefan Uhlig and Christian Martin

    Citation: Respiratory Research 2019 20:111

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  34. Content type: Research

    Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model ...

    Authors: Fajer Al-Shamlan and Ahmed Z. El-Hashim

    Citation: Respiratory Research 2019 20:110

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  35. Content type: Research

    The differential diagnosis of paediatric respiratory conditions is difficult and suboptimal. Existing diagnostic algorithms are associated with significant error rates, resulting in misdiagnoses, inappropriate...

    Authors: Paul Porter, Udantha Abeyratne, Vinayak Swarnkar, Jamie Tan, Ti-wan Ng, Joanna M. Brisbane, Deirdre Speldewinde, Jennifer Choveaux, Roneel Sharan, Keegan Kosasih and Phillip Della

    Citation: Respiratory Research 2019 20:81

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  36. Content type: Research

    Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously ...

    Authors: Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch and Fumito Ichinose

    Citation: Respiratory Research 2019 20:109

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  37. Content type: Research

    Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and ...

    Authors: Xiao-feng Xiong, Min Zhu, Hong-xia Wu, Li-li Fan and De-yun Cheng

    Citation: Respiratory Research 2019 20:108

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  38. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships...

    Authors: Laurie Snyder, Megan L. Neely, Anne S. Hellkamp, Emily O’Brien, Joao de Andrade, Craig S. Conoscenti, Thomas Leonard, Shaun Bender, Mridu Gulati, Daniel A. Culver, Robert J. Kaner, Scott Palmer and Hyun Joo Kim

    Citation: Respiratory Research 2019 20:105

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  39. Content type: Research

    Tumor chemo-resistance is a hallmark of malignant tumors as well as the major cause of poor survival rates in lung cancer. Transmembrane-4 L-six family member-1 (TM4SF1), an antigen that serves as an oncogene, ma...

    Authors: Lin Ye, Chunyun Pu, Jun Tang, Yan Wang, Can Wang, Zhu Qiu, Tingxiu Xiang, Yunmei Zhang and Weiyan Peng

    Citation: Respiratory Research 2019 20:106

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  40. Content type: Research

    To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in ch...

    Authors: Paola Rogliani, Maria Gabriella Matera, Clive Page, Ermanno Puxeddu, Mario Cazzola and Luigino Calzetta

    Citation: Respiratory Research 2019 20:104

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  41. Content type: Research

    Surveys and retrospective studies of patients with idiopathic pulmonary fibrosis (IPF) have shown a significant diagnostic delay. However, the causes and risk factors for this delay are not known.

    Authors: Nils Hoyer, Thomas Skovhus Prior, Elisabeth Bendstrup, Torgny Wilcke and Saher Burhan Shaker

    Citation: Respiratory Research 2019 20:103

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  42. Content type: Research

    Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypot...

    Authors: Petra Um-Bergström, Jenny Hallberg, Melvin Pourbazargan, Eva Berggren-Broström, Giovanni Ferrara, Maria J. Eriksson, Sven Nyrén, Jing Gao, Gunnar Lilja, Anders Lindén, Åsa M. Wheelock, Erik Melén and C. Magnus Sköld

    Citation: Respiratory Research 2019 20:102

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  43. Content type: Research

    The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry,...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, Ronald A. Karwoski, Cosimo Nardi, Riccardo Inchingolo, Anna R. Larici, Gianna Camiciottoli, Federico Lavorini, Stefano Colagrande, Vito Brusasco and Massimo Pistolesi

    Citation: Respiratory Research 2019 20:101

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  44. Content type: Research

    Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin serum levels. Interestingly, patients with Chronic Obstr...

    Authors: Cédric Vonarburg, Marius Loetscher, Martin O. Spycher, Alain Kropf, Marlies Illi, Sharon Salmon, Sean Roberts, Karin Steinfuehrer, Ian Campbell, Sandra Koernig, Joseph Bain, Monika Edler, Ulrich Baumann, Sylvia Miescher, Dennis W. Metzger, Alexander Schaub…

    Citation: Respiratory Research 2019 20:99

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  45. Content type: Research

    Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and ...

    Authors: Wilfried Karmaus, Nandini Mukherjee, Vimala Devi Janjanam, Su Chen, Hongmei Zhang, Graham Roberts, Ramesh J. Kurukulaaratchy and Hasan Arshad

    Citation: Respiratory Research 2019 20:98

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  46. Content type: Research

    We recently showed that intravenous sodium nitroprusside treatment (SNP) could relieve the pulmonary vasospasm of pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions in a rabbit massive pulmona...

    Authors: Yuting Wang, Delong Yu, Yijun Yu, Wusong Zou, Xiaohui Zeng, Liqun Hu and Ye Gu

    Citation: Respiratory Research 2019 20:97

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  47. Content type: Research

    Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflam...

    Authors: Lei Liu, Xin Zhang, Ying Liu, Li Zhang, Jing Zheng, Ji Wang, Philip M. Hansbro, Lei Wang, Gang Wang and Alan Chen-Yu Hsu

    Citation: Respiratory Research 2019 20:95

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