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  1. Content type: Research

    Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

    Authors: Xu Liu, Mei Mei, Xiang Chen, Yulan Lu, Xinran Dong, Liyuan Hu, Xiaojing Hu, Guoqiang Cheng, Yun Cao, Lin Yang and Wenhao Zhou

    Citation: Respiratory Research 2019 20:174

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  2. Content type: Commentary

    Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

    Authors: David A. Leather, Louisa Yates, Henrik Svedsater, Loretta Jacques, Susan Collier, Danielle Powell and Rupert Jones

    Citation: Respiratory Research 2019 20:173

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  3. Content type: Research

    Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

    Authors: Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall and Ian Sayers

    Citation: Respiratory Research 2019 20:172

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  4. Content type: Research

    Metabolic adaptation in immune cells is necessary to modulate immune cell function as it is intricately coupled with intracellular metabolism. We aimed to characterize the metabolic state of human peripheral b...

    Authors: Amit R Agarwal, Smita Kadam, Ankita Brahme, Manas Agrawal, Komalkirti Apte, Govinda Narke, Kushal Kekan, Sapna Madas and Sundeep Salvi

    Citation: Respiratory Research 2019 20:171

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  5. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

    Authors: Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro and Mona Bafadhel

    Citation: Respiratory Research 2019 20:170

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  6. Content type: Research

    We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

    Authors: Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey and Namhee Kwon

    Citation: Respiratory Research 2019 20:169

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  7. Content type: Research

    Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosi...

    Authors: Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert Guzy, Gökhan M. Mutlu and Nickolai O. Dulin

    Citation: Respiratory Research 2019 20:168

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  8. Content type: Research

    Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate...

    Authors: Edward M. Kerwin, Gary T. Ferguson, Mindy Mo, Kiernan DeAngelis and Paul Dorinsky

    Citation: Respiratory Research 2019 20:167

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  9. Content type: Research

    Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in card...

    Authors: Yousef S. Aldabayan, Heidi A. Ridsdale, Ahmed M. Alrajeh, Abdulelah M. Aldhahir, Arthur Lemson, Jaber S. Alqahtani, Jeremy S. Brown and John R. Hurst

    Citation: Respiratory Research 2019 20:166

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  10. Content type: Research

    Complement factor C5 can either aggravate or attenuate the T-helper type 2 (TH2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phas...

    Authors: Jack Yang, Ivan Ramirez Moral, Cornelis van ’t Veer, Alex F. de Vos, Regina de Beer, Joris J. T. H. Roelofs, B. Paul Morgan and Tom van der Poll

    Citation: Respiratory Research 2019 20:165

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  11. Content type: Research

    Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about t...

    Authors: Yang Zhang, Yuanyuan Zeng, Ting Liu, Wenwen Du, Jianjie Zhu, Zeyi Liu and Jian-an Huang

    Citation: Respiratory Research 2019 20:164

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  12. Content type: Research

    Pulmonary fibrosis is a progressive and irreversible disease for which therapeutic options are currently limited. A recent in vivo study showed that tenofovir, a nucleotide analogue reverse transcriptase inhib...

    Authors: Lingxia Li, Jing Zhao, Li Zhou, Jie Chen, Yuanyuan Ma, Yanyan Yu and Jun Cheng

    Citation: Respiratory Research 2019 20:163

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  13. Content type: Review

    Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessari...

    Authors: Guanghui Liu, Catherine Betts, Danen M. Cunoosamy, Per M. Åberg, Jorrit J. Hornberg, Kinga Balogh Sivars and Taylor S. Cohen

    Citation: Respiratory Research 2019 20:162

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  14. Content type: Research

    Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS)...

    Authors: Woori Kim, Michael H. Cho, Phuwanat Sakornsakolpat, David A. Lynch, Harvey O. Coxson, Ruth Tal-Singer, Edwin K. Silverman and Terri H. Beaty

    Citation: Respiratory Research 2019 20:160

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  15. Content type: Research

    The primary lung function endpoint in clinical trials in adolescent and adult patients with asthma is usually forced expiratory volume in one second (FEV1). The objective of our analysis was to assess whether pea...

    Authors: David M. G. Halpin, Eli O. Meltzer, Wendelgard Pisternick-Ruf, Petra Moroni-Zentgraf, Michael Engel, Liliana Zaremba-Pechmann, Thomas Casale and J. Mark FitzGerald

    Citation: Respiratory Research 2019 20:159

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  16. Content type: Research

    Respiratory Distress Syndrome (RDS) is a prematurity-related breathing disorder caused by a quantitative deficiency of pulmonary surfactant. Surfactant replacement therapy is effective for RDS newborns, althou...

    Authors: Sonia Giambelluca, Francesca Ricci, Manuela Simonato, Luca Vedovelli, Umberto Traldi, Alessio Correani, Costanza Casiraghi, Matteo Storti, Arianna Mersanne, Paola Cogo, Fabrizio Salomone and Virgilio P. Carnielli

    Citation: Respiratory Research 2019 20:158

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  17. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship betwe...

    Authors: Balázs Csoma, András Bikov, Lajos Nagy, Bence Tóth, Tamás Tábi, Gergő Szűcs, Zsolt István Komlósi, Veronika Müller, György Losonczy and Zsófia Lázár

    Citation: Respiratory Research 2019 20:156

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  18. Content type: Research

    Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung i...

    Authors: Renata de S. Mendes, Milena V. Oliveira, Gisele A. Padilha, Nazareth N. Rocha, Cintia L. Santos, Ligia A. Maia, Marcos V. de S. Fernandes, Fernanda F. Cruz, Priscilla C. Olsen, Vera L. Capelozzi, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R. M. Rocco and Pedro L. Silva

    Citation: Respiratory Research 2019 20:155

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  19. Content type: Research

    Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study ...

    Authors: Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Daisuke Okuno, Hirokazu Yura, Shota Nakashima, Hiroshi Ishimoto, Takashi Kido, Daisuke Taniguchi, Takuro Miyazaki, Tomoshi Tsuchiya, Shin Tsutsui, Hiroyuki Yamaguchi, Yasushi Obase, Yuji Ishimatsu, Kazuto Ashizawa…

    Citation: Respiratory Research 2019 20:154

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  20. Content type: Research

    Quantitative computed tomographic (QCT) imaging-based metrics enable to quantify smoking induced disease alterations and to identify imaging-based clusters for current smokers. We aimed to derive clinically me...

    Authors: Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, Chang Hyun Lee, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup…

    Citation: Respiratory Research 2019 20:153

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  21. Content type: Research

    Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells relate within and between these two biological co...

    Authors: Tamara Cruz, Alejandra López-Giraldo, Guillaume Noell, Sandra Casas-Recasens, Tamara Garcia, Laureano Molins, Manel Juan, Marco A. Fernandez, Alvar Agustí and Rosa Faner

    Citation: Respiratory Research 2019 20:152

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  22. Content type: Research

    The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function o...

    Authors: Franziska C. Trudzinski, Mohamad Alqudrah, Albert Omlor, Stephen Zewinger, Danilo Fliser, Timotheus Speer, Frederik Seiler, Frank Biertz, Armin Koch, Claus Vogelmeier, Tobias Welte, Henrik Watz, Benjamin Waschki, Sebastian Fähndrich, Rudolf Jörres and Robert Bals

    Citation: Respiratory Research 2019 20:151

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  23. Content type: Research

    Human rhinovirus (HRV) infections are the primary cause of the common cold and are a major trigger for exacerbations of lower airway diseases, such as asthma and chronic obstructive pulmonary diseases. Althoug...

    Authors: Stephanie M. Warner, Shahina Wiehler, Aubrey N. Michi and David Proud

    Citation: Respiratory Research 2019 20:150

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  24. Content type: Research

    Supplemental oxygen therapy is widely used in hospitals and in the home for chronic care. However, there are several fundamental problems with the application of this therapy such that patients are often expos...

    Authors: Ira Katz, John Chen, Kelvin Duong, Kaixian Zhu, Marine Pichelin, Georges Caillibotte and Andrew R. Martin

    Citation: Respiratory Research 2019 20:149

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  25. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying ...

    Authors: Louise A. Organ, Anne-Marie R. Duggan, Eunice Oballa, Sarah C. Taggart, Juliet K. Simpson, Arthur R. Kang’ombe, Rebecca Braybrooke, Philip L. Molyneaux, Bernard North, Yakshitha Karkera, Diana J. Leeming, Morten A. Karsdal, Carmel B. Nanthakumar, William A. Fahy, Richard P. Marshall, R. Gisli Jenkins…

    Citation: Respiratory Research 2019 20:148

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  26. Content type: Research

    Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and...

    Authors: Esther P.W.A. Talboom-Kamp, Marije S. Holstege, Niels H. Chavannes and Marise J. Kasteleyn

    Citation: Respiratory Research 2019 20:146

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  27. Content type: Research

    Airway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; howe...

    Authors: Patrizia Pignatti, Dina Visca, Francesca Cherubino, Elisabetta Zampogna, Etienne Lucini, Laura Saderi, Giovanni Sotgiu and Antonio Spanevello

    Citation: Respiratory Research 2019 20:145

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  28. Content type: Review

    The risk and prevalence of chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis (RA) is still obscure. The current study was aimed to systematically review and meta-analyse the risk ratio (RR) ...

    Authors: Yubo Ma, Hui Tong, Xu Zhang, Mengmeng Wang, Jiajia Yang, Meng Wu, Renfang Han, Mengya Chen, Xingxing Hu, Yaping Yuan, Guixia Pan, Yanfeng Zou, Shengqian Xu and Faming Pan

    Citation: Respiratory Research 2019 20:144

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  29. Content type: Research

    Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate t...

    Authors: Ying Duan, Gaowen Liu, Yao Sun, Jiamin Wu, Zichao Xiong, Tianbo Jin and Mingwei Chen

    Citation: Respiratory Research 2019 20:143

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  30. Content type: Review

    There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1...

    Authors: Dave Singh, Anthony D. D’Urzo, James F. Donohue and Edward M. Kerwin

    Citation: Respiratory Research 2019 20:141

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  31. Content type: Research

    Bronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenc...

    Authors: Juergen Hetzel, Ralf Eberhardt, Christoph Petermann, Wolfgang Gesierich, Kaid Darwiche, Lars Hagmeyer, Rainer Muche, Michael Kreuter, Richard Lewis, Ahmed Ehab, Michael Boeckeler and Maik Haentschel

    Citation: Respiratory Research 2019 20:140

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  32. Content type: Research

    Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The s...

    Authors: Kingsley Katleho Mokoena, Crystal Jane Ethan, Yan Yu, Karabo Shale and Feng Liu

    Citation: Respiratory Research 2019 20:139

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  33. Content type: Research

    Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized. Our investigation of 28,727 chest X-rays obtained from annual health...

    Authors: Akira Saito, Yukichika Hakamata, Yukiko Yamada, Mitsuhiro Sunohara, Megumi Tarui, Yoko Murano, Akihisa Mitani, Kimie Tanaka, Takahide Nagase and Shintaro Yanagimoto

    Citation: Respiratory Research 2019 20:138

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  34. Content type: Letter to the Editor

    The severity of Hereditary Hemorrhagic Telangiectasia (HHT) disease is generally related to vascular visceral involvement represented by arteriovenous malformations (AVMs). Pulmonary function tests (PFTs) rema...

    Authors: Carole de Picciotto, Mostafa El Hajjam, Carma Karam, Thierry Chinet and Marcel Bonay

    Citation: Respiratory Research 2019 20:137

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  35. Content type: Research

    The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors fo...

    Authors: Yunjoo Im, Hye Yun Park, Sumin Shin, Sun Hye Shin, Hyun Lee, Joong Hyun Ahn, Insuk Sohn, Jong Ho Cho, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Ho Yun Lee and Jhingook Kim

    Citation: Respiratory Research 2019 20:136

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  36. Content type: Research

    Smoking is a major risk factor for COPD and may impact the efficacy of COPD treatments; however, a large proportion of COPD patients continue to smoke following diagnosis.

    Authors: Donald P. Tashkin, Thomas Goodin, Alyssa Bowling, Barry Price, Ayca Ozol-Godfrey, Sanjay Sharma and Shahin Sanjar

    Citation: Respiratory Research 2019 20:135

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  37. Content type: Research

    Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical cha...

    Authors: F. Bianco, F. Ricci, C. Catozzi, X. Murgia, M. Schlun, A. Bucholski, U. Hetzer, S. Bonelli, M. Lombardini, E. Pasini, M. Nutini, M. Pertile, S. Minocchieri, M. Simonato, B. Rosa, G. Pieraccini…

    Citation: Respiratory Research 2019 20:134

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  38. Content type: Research

    Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung...

    Authors: Francesca Polverino, Bao Lu, Joselyn Rojas Quintero, Sara O. Vargas, Avignat S. Patel, Caroline A. Owen, Norma P. Gerard, Craig Gerard and Manuela Cernadas

    Citation: Respiratory Research 2019 20:133

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  39. Content type: Research

    Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who are unable to administer medications efficiently with conventional inhalers may benefit from the use of a n...

    Authors: Brian R. Leaker, Dave Singh, Grant C. Nicholson, Blanka Hezelova, Thomas Goodin, Ayca Ozol-Godfrey, Gerald Galluppi and Peter J. Barnes

    Citation: Respiratory Research 2019 20:132

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  40. Content type: Research

    Patients with acute lung injury (ALI) have increased levels of pro-inflammatory mediators, which impair endothelial progenitor cell (EPC) function. Increasing the number of EPC and alleviating EPC dysfunction ...

    Authors: Nana Yang, Hua Tian, Enxin Zhan, Lei Zhai, Peng Jiao, Shutong Yao, Guohua Lu, Qingjie Mu, Juan Wang, Aihua Zhao, Yadong Zhou and Shucun Qin

    Citation: Respiratory Research 2019 20:131

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  41. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce excessive extracellular matrix accumula...

    Authors: Arnoldo Aquino-Gálvez, Georgina González-Ávila, Laura Lorena Jiménez-Sánchez, Héctor Aquiles Maldonado-Martínez, José Cisneros, Fernanda Toscano-Marquez, Manuel Castillejos-López, Luz María Torres-Espíndola, Rafael Velázquez-Cruz, Víctor Hugo Olivera Rodríguez, Edgar Flores-Soto, Héctor Solís-Chagoyán, Carlos Cabello, Joaquín Zúñiga and Yair Romero

    Citation: Respiratory Research 2019 20:130

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  42. Content type: Research

    Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its ant...

    Authors: Ari Jon Arason, Jon Petur Joelsson, Bryndis Valdimarsdottir, Snaevar Sigurdsson, Alexander Gudjonsson, Skarphedinn Halldorsson, Freyr Johannsson, Ottar Rolfsson, Fredrik Lehmann, Saevar Ingthorsson, Paulina Cherek, Gudmundur H. Gudmundsson, Fridrik R. Gardarsson, Clive P. Page, Olafur Baldursson, Thorarinn Gudjonsson…

    Citation: Respiratory Research 2019 20:129

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  43. Content type: Research

    Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis...

    Authors: Michael E. O’Brien, Divay Chandra, Robert C. Wilson, Chad M. Karoleski, Carl R. Fuhrman, Joseph K. Leader, Jiantao Pu, Yingze Zhang, Alison Morris, Seyed Nouraie, Jessica Bon, Zsolt Urban and Frank C. Sciurba

    Citation: Respiratory Research 2019 20:128

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  44. Content type: Research

    Viral respiratory infection (VRI) is a common contraindication to elective surgery. Asymptomatic shedding among pediatric surgery patients (PSPs) could potentially lead to progression of symptomatic diseases a...

    Authors: Dan Zhang, Xiuyu Lou, Hao Yan, Junhang Pan, Haiyan Mao, Hongfeng Tang, Yan Shu, Yun Zhao, Lei Liu, Junping Li, Dong Chen, Yanjun Zhang and Xuejun Ma

    Citation: Respiratory Research 2019 20:126

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  45. Content type: Research

    Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possib...

    Authors: Marcell Szily, Adam D. Tarnoki, David L. Tarnoki, Daniel T. Kovacs, Bianka Forgo, Jooyeon Lee, Eunae Kim, Joohon Sung, Laszlo Kunos, Martina Meszaros, Veronika Muller and Andras Bikov

    Citation: Respiratory Research 2019 20:125

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  46. Content type: Research

    Allergic mechanisms related to environmental and occupational exposure have been suggested to contribute to the development of chronic obstructive pulmonary disease (COPD).

    Authors: Matthieu Veil-Picard, Thibaud Soumagne, Rechana Vongthilath, Isabella Annesi-Maesano, Alicia Guillien, Lucie Laurent, Pascal Andujar, Nicolas Roche, Stephane Jouneau, Benoit Cypriani, Jean-Jacques Laplante, Bruno Degano and Jean-Charles Dalphin

    Citation: Respiratory Research 2019 20:124

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  47. Content type: Research

    Right ventricular (RV) angiogenesis has been associated with adaptive myocardial remodeling in pulmonary hypertension (PH), though molecular regulators are poorly defined. Endothelial cell VEGFR-2 is considere...

    Authors: Grace L. Peloquin, Laura Johnston, Mahendra Damarla, Rachel L. Damico, Paul M. Hassoun and Todd M. Kolb

    Citation: Respiratory Research 2019 20:123

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