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  1. Electronic cigarettes (e-cigarettes) are used worldwide as a substitute for conventional cigarettes. Although they are primarily intended to support smoking cessation, e-cigarettes have been identified as a ga...

    Authors: Moegi Komura, Tadashi Sato, Hitomi Yoshikawa, Naoko Arano Nitta, Yohei Suzuki, Kengo Koike, Yuzo Kodama, Kuniaki Seyama and Kazuhisa Takahashi
    Citation: Respiratory Research 2022 23:216
  2. Sialic acid is often the distal sugar on glycoconjugates, and sialidases are enzymes that remove this sugar. In fibrotic lesions in human and mouse lungs, there is extensive desialylation of glycoconjugates, a...

    Authors: Darrell Pilling, Kyle Sahlberg, Tejas R. Karhadkar, Wensheng Chen and Richard H. Gomer
    Citation: Respiratory Research 2022 23:215
  3. While there seems to be a consensus that a decrease in gut microbiome diversity is related to a decline in health status, the associations between respiratory microbiome diversity and chronic lung disease rema...

    Authors: Marta Avalos-Fernandez, Thibaud Alin, Clémence Métayer, Rodolphe Thiébaut, Raphaël Enaud and Laurence Delhaes
    Citation: Respiratory Research 2022 23:214
  4. Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD exacerbations are associated with a worsening of lung function, increased disease burden, and mortalit...

    Authors: John R. Hurst, MeiLan K. Han, Barinder Singh, Sakshi Sharma, Gagandeep Kaur, Enrico de Nigris, Ulf Holmgren and Mohd Kashif Siddiqui
    Citation: Respiratory Research 2022 23:213
  5. Early identification of chronic obstructive pulmonary disease (COPD) in young individuals could be beneficial to attempt preventive interventions. The objective of this study was to investigate clinical featur...

    Authors: Yong Suk Jo, Kyung Joo Kim, Chin Kook Rhee, Kwang Ha Yoo, Ki-Suck Jung and Yong-Bum Park
    Citation: Respiratory Research 2022 23:212
  6. Elevated ACE expression in tissues (reflected by blood ACE levels) is associated with increased risk of cardiovascular diseases and is also a marker for granulomatous diseases. We developed a new approach for ...

    Authors: Sergei M. Danilov, Olga V. Kurilova, Valentin E. Sinitsyn, Armais A. Kamalov, Joe G. N. Garcia and Steven M. Dudek
    Citation: Respiratory Research 2022 23:211
  7. Diaphragmatic dysfunction is a major factor responsible for weaning failure in patients that underwent prolonged invasive mechanical ventilation for acute severe respiratory failure from COVID-19. This study h...

    Authors: Luigi Vetrugno, Daniele Orso, Francesco Corradi, Gianluca Zani, Savino Spadaro, Francesco Meroi, Natascia D’Andrea, Tiziana Bove, Gianmaria Cammarota, Edoardo De Robertis, Samuele Ferrari, Marcello Guarnieri, Margherita Ajuti, Maurizio Fusari, Domenico Luca Grieco, Cristian Deana…
    Citation: Respiratory Research 2022 23:210
  8. Pulmonary hypertension (PH) is a progressive and fatal cardiopulmonary disease characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance and artery pressure. Vascular remodelin...

    Authors: Haitao Liu, Sha Zhang, Yi Liu, Jing Ma, Wei Chen, Tao Yin, Tongbin Li, Bin Liang and Ling Tao
    Citation: Respiratory Research 2022 23:209
  9. Chronic obstructive pulmonary disease (COPD) and interstital lung disease (ILD) are incurable conditions characterised by airflow limitation, persisting respiratory symptoms, and progressive respiratory failur...

    Authors: Natasha Smallwood, Amy Pascoe, Sara Vogrin and Jennifer Philip
    Citation: Respiratory Research 2022 23:208
  10. Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atheroscler...

    Authors: Giuseppe De Luca, Matteo Nardin, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto di Uccio, Clemens von Birgelen…
    Citation: Respiratory Research 2022 23:207
  11. Variants of NHL repeat-containing protein 2 (NHLRC2) have been associated with severe fibrotic interstitial lung disease in early childhood and NHLRC2 has been listed as a differentially expressed gene between ra...

    Authors: Mervi Kreus, Siri Lehtonen, Reetta Hinttala, Johanna Salonen, Katja Porvari and Riitta Kaarteenaho
    Citation: Respiratory Research 2022 23:206
  12. Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endotheli...

    Authors: Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery and Hongwei Yao
    Citation: Respiratory Research 2022 23:205
  13. Silicosis is a pulmonary fibrosis-associated disease caused by the inhalation of large amounts of free silicon dioxide (SiO2) that mainly manifests as early inflammation and late pulmonary fibrosis. As macrophage...

    Authors: Yaping Liu, Xinxin Zhang, Jing Wang, Fuhuang Yang, Wei Luo, Jie Huang, Mengling Chen, Sha Wang, Caolong Li, Wei Zhang and Jie Chao
    Citation: Respiratory Research 2022 23:204
  14. The National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails to take account of the detailed granularity or temporal trends in clinical observations. We used da...

    Authors: Sherif Gonem, Adam Taylor, Grazziela Figueredo, Sarah Forster, Philip Quinlan, Jonathan M. Garibaldi, Tricia M. McKeever and Dominick Shaw
    Citation: Respiratory Research 2022 23:203
  15. The efficacy and safety of complement inhibition in COVID-19 patients is unclear.

    Authors: Elisabeth De Leeuw, Karel F. A. Van Damme, Jozefien Declercq, Cedric Bosteels, Bastiaan Maes, Simon J. Tavernier, Laurent Detalle, Trevor Smart, Sophie Glatt, Nincy Debeuf, Julie Deckers, Sahine Lameire, Stefaan J. Vandecasteele, Nikolaas De Neve, Ingel K. Demedts, Elke Govaerts…
    Citation: Respiratory Research 2022 23:202
  16. Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissu...

    Authors: Christina Hesse, Valerie Beneke, Sebastian Konzok, Claudia Diefenbach, Jannie Marie Bülow Sand, Sarah Rank Rønnow, Morten Asser Karsdal, Danny Jonigk, Katherina Sewald, Armin Braun, Diana Julie Leeming and Lutz Wollin
    Citation: Respiratory Research 2022 23:201
  17. Identification of COPD patients with a rapid decline in FEV1 is of particular interest for prognostic and therapeutic reasons.

    Authors: Antonino Di Stefano, Francesca Dossena, Isabella Gnemmi, Silvestro Ennio D’Anna, Paola Brun, Bruno Balbi, Alessio Piraino, Antonio Spanevello, Francesco Nucera, Vitina Carriero, Francesca Bertolini, Mauro Maniscalco, Ian M. Adcock, Gaetano Caramori and Fabio L. M. Ricciardolo
    Citation: Respiratory Research 2022 23:200
  18. The mid-term respiratory sequelae in survivors of severe COVID-19 appear highly heterogeneous. In addition, factors associated with respiratory sequelae are not known. In this monocentric prospective study, we...

    Authors: Jeanne-Marie Perotin, Fabien Gierski, Lois Bolko, Sandra Dury, Sarah Barrière, Claire Launois, Maxime Dewolf, Stéphane Chouabe, Eric Bongrain, Davy Picard, Eric Tran, Yoann N’Guyen, Bruno Mourvillier, Amélie Servettaz, Amandine Rapin, Claude Marcus…
    Citation: Respiratory Research 2022 23:199
  19. Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV10) for children aged < 1 year in March 2015. Previous vaccine effectiveness (VE) studies for pneumonia have used invasive pneumococcal di...

    Authors: William Checkley, Shakir Hossen, Eric D. McCollum, Farhan Pervaiz, Catherine H. Miele, Miguel A. Chavez, Lawrence H. Moulton, Nicole Simmons, Arunangshu D. Roy, Nabidul H. Chowdhury, Salahuddin Ahmed, Nazma Begum, Abdul Quaiyum, Mathuram Santosham and Abdullah H. Baqui
    Citation: Respiratory Research 2022 23:198
  20. The characteristics of coal dust (CD) particles affect the inhalation of CD, which causes coal worker’s pneumoconiosis (CWP). CD nanoparticles (CD-NPs, < 500 nm) and micron particles (CD-MPs, < 5 μm) are compo...

    Authors: Yinci Zhang, Amin Li, Jiafeng Gao, Jiaojiao Liang, Niandie Cao, Shuping Zhou and Xiaolong Tang
    Citation: Respiratory Research 2022 23:197
  21. Mechanosensitive Piezo ion channels were first reported in 2010 in a mouse neuroblastoma cell line, opening up a new field for studying the composition and function of eukaryotic mechanically activated channel...

    Authors: Huaiyu Xiong, Jing Yang, Jun Guo, Aijia Ma, Bo Wang and Yan Kang
    Citation: Respiratory Research 2022 23:196
  22. Hemorrhage shock (HS) is characterized by decreased tissue oxygenation and organ damage due to severe blood loss. Protein tyrosine phosphatase receptor type O (PTPRO) is abnormally up-regulated in the rat lung...

    Authors: Zhirong Huan, Ying Tang, Ce Xu, Jimin Cai, Hao Yao, Yan Wang, Fanyu Bu and Xin Ge
    Citation: Respiratory Research 2022 23:195
  23. Body mass index (BMI) has been shown to be associated with lung function. Recent findings showed that DNA methylation (DNAm) variation is likely to be a consequence of changes in BMI. However, whether DNAm med...

    Authors: Rutu Rathod, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, Fawaz Mzayek, S. Hasan Arshad and John W. Holloway
    Citation: Respiratory Research 2022 23:194
  24. CCAAT/Enhancer Binding Protein D (CEBPD), a pleiotropic glucocorticoid-responsive transcription factor, modulates inflammatory responses. Of relevance to asthma, expression of CEBPD in airway smooth muscle (ASM) ...

    Authors: Mengyuan Kan, Maoyun Sun, Xiaofeng Jiang, Avantika R. Diwadkar, Vishal Parikh, Gaoyuan Cao, Eric Gebski, William Jester, Bo Lan, Reynold A. Panettieri Jr, Cynthia Koziol-White, Quan Lu and Blanca E. Himes
    Citation: Respiratory Research 2022 23:193
  25. Inhalation corticosteroids (ICS) are prescribed for treatment of asthma in approximately 3% of all children in Denmark. Despite limited evidence, case reports suggest that ICS-related behavioural adverse drug ...

    Authors: Karoline S. Bodum, Britta E. Hjerrild, Søren Dalsgaard and Sune L. M. Rubak
    Citation: Respiratory Research 2022 23:192
  26. Although still considered a safer alternative to classical cigarettes, growing body of work points to harmful effects of electronic cigarettes (e-cigarettes) affecting a range of cellular processes. The biolog...

    Authors: Sara Trifunovic, Katarina Smiljanić, Albert Sickmann, Fiorella A. Solari, Stoimir Kolarevic, Aleksandra Divac Rankov and Mila Ljujic
    Citation: Respiratory Research 2022 23:191
  27. As a DNA surveillance mechanism, cell cycle checkpoint has recently been discovered to be closely associated with lung adenocarcinoma (LUAD) prognosis. It is also an essential link in the process of DNA damage...

    Authors: Quan Li, Pan Zhang, Huixiao Hu, Hang Huang, Dong Pan, Guangyun Mao and Burong Hu
    Citation: Respiratory Research 2022 23:190
  28. PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the airway tone are almost unknown. We stud...

    Authors: Annette D. Rieg, Said Suleiman, Carolin Anker, Nina A. Bünting, Eva Verjans, Jan Spillner, Sebastian Kalverkamp, Saskia von Stillfried, Till Braunschweig, Stefan Uhlig and Christian Martin
    Citation: Respiratory Research 2022 23:189
  29. Assessing the humoral immunity of patients with underlying diseases after being infected with SARS-CoV-2 is essential for adopting effective prevention and control strategies. The purpose of this study is to a...

    Authors: Jin Yang, Libing Ma, Li Guo, Ting Zhang, Zhiwei Leng, Mengmeng Jia, Fangyuan Chen, Weiran Qi, Xingxing Zhang, Qing Wang, Yuan Yang, Luzhao Feng, Lili Ren, Weizhong Yang and Chen Wang
    Citation: Respiratory Research 2022 23:188

    The Correction to this article has been published in Respiratory Research 2022 23:218

  30. Some COVID-19 patients experience dyspnea without objective impairment of pulmonary or cardiac function. This study determined diaphragm function and its central voluntary activation as a potential correlate w...

    Authors: Jens Spiesshoefer, Janina Friedrich, Binaya Regmi, Jonathan Geppert, Benedikt Jörn, Alexander Kersten, Alberto Giannoni, Matthias Boentert, Gernot Marx, Nikolaus Marx, Ayham Daher and Michael Dreher
    Citation: Respiratory Research 2022 23:187
  31. Some evidences have shown the association between air pollution exposure and the development of interstitial lung diseases. However, the effect of air pollution on the progression of restrictive ventilatory im...

    Authors: Chi-Hsien Chen, Chih-Da Wu, Ya Ling Lee, Kang-Yun Lee, Wen-Yi Lin, Jih-I Yeh, Hsing-Chun Chen and Yue-Liang Leon Guo
    Citation: Respiratory Research 2022 23:186
  32. Sarcopenia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD), but its relationship with chronic obstructive pulmonary disease (COPD) has not been fully determined. This study...

    Authors: Ah Young Leem, Young Sam Kim, Kung Soo Chung, Moo Suk Park, Young Ae Kang, Young-Mok Park and Ji Ye Jung
    Citation: Respiratory Research 2022 23:185
  33. Ventilator liberation is one of the most challenging aspects in patients with respiratory failure. Most patients are weaned through a transition from full to partial respiratory support, whereas some advocate ...

    Authors: Jefta van Dijk, Alette A. Koopman, Limme B. de Langen, Sandra Dijkstra, Johannes G. M. Burgerhof, Robert G. T. Blokpoel and Martin C. J. Kneyber
    Citation: Respiratory Research 2022 23:184
  34. Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequen...

    Authors: Rebecca Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms and Jill R. Johnson
    Citation: Respiratory Research 2022 23:183
  35. To establish the predicted value of pulmonary function determined by impulse oscillometry (IOS) in children (4–17 years old) in China.

    Authors: Jinhong Wu, Hao Zhang, Yongsheng Shi, Jinrong Wang, Yuling Han, Qiaoling Zhang, Ning Wang, Sha Liu, Yuehua Zhang, Huifen Zi, Fei Wang, Aihong Liu, Yuxin Song, ChunMei Jia, Yong Feng, Quanhua Liu…
    Citation: Respiratory Research 2022 23:182
  36. While nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric acute respiratory distress syndrome (PARDS).

    Authors: James G. Williams, Rashika Joshi, David Haslam, Nadir Yehya, Rhonda L. Jones, Aditi Paranjpe, Mario Pujato, Krishna M. Roskin, Patrick M. Lahni, Hector R. Wong and Brian M. Varisco
    Citation: Respiratory Research 2022 23:181
  37. Idiopathic pulmonary fibrosis (IPF) is a diffuse parenchymal lung disease characterized by exuberant deposition of extracellular matrix (ECM) proteins in the lung interstitium, which contributes to substantial...

    Authors: Tina Bormann, Regina Maus, Jennifer Stolper, Meritxell Tort Tarrés, Christina Brandenberger, Dirk Wedekind, Danny Jonigk, Tobias Welte, Jack Gauldie, Martin Kolb and Ulrich A. Maus
    Citation: Respiratory Research 2022 23:180
  38. The forced vital capacity (FVC) of healthy individuals depends on their age, sex, ethnicity and height. Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is characterised by loss of FVC. We com...

    Authors: Toby M. Maher, Arnaud Bourdin, Elizabeth R. Volkmann, Serena Vettori, Jörg H. W. Distler, Margarida Alves, Christian Stock and Oliver Distler
    Citation: Respiratory Research 2022 23:178
  39. Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insights regarding the deve...

    Authors: Sara T. Humes, Nicole Iovine, Cindy Prins, Timothy J. Garrett, John A. Lednicky, Eric S. Coker and Tara Sabo-Attwood
    Citation: Respiratory Research 2022 23:177
  40. Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, in...

    Authors: Jia Hou, Xia Wang, Chunxia Su, Weirong Ma, Xiwei Zheng, Xiahui Ge and Xiangguo Duan
    Citation: Respiratory Research 2022 23:176
  41. Sputum biopsies offer unique advantages such as non-invasiveness and convenient collection. The one investigation so far on sputum for genome profiling in advanced non-small cell lung cancer (aNSCLC) suggested...

    Authors: Xiaohong Xie, Jianhui Wu, Bingpeng Guo, Liqiang Wang, Haiyi Deng, Xinqing Lin, Ming Liu, Yinyin Qin, Wei Luo, Yilin Yang, Xiao Zou, Ting Hou, Jianxing Xiang, Zhange Chen and Chengzhi Zhou
    Citation: Respiratory Research 2022 23:175
  42. Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we exami...

    Authors: Houman Goudarzi, Hirokazu Kimura, Hiroki Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Kaoruko Shimizu, Masaru Suzuki, Taku Watanabe, Eiki Kikuchi, Hiroshi Ohira, Ichizo Tsujino, Jun Sakakibara-Konishi, Naofumi Shinagawa, Noriharu Shijubo, Hirokazu Sato…
    Citation: Respiratory Research 2022 23:174
  43. Chronic obstructive pulmonary disease (COPD) is a health problem that results in death, commonly due to the development of pulmonary hypertension (PH). Here, by utilizing a mouse model of intratracheal elastas...

    Authors: Ratoe Suraya, Tatsuya Nagano, Gusty Rizky Teguh Ryanto, Wiwin Is Effendi, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Noriaki Emoto, Yoshihiro Nishimura and Kazuyuki Kobayashi
    Citation: Respiratory Research 2022 23:173
  44. Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. Discovering the potential metabolic alterations underlying the ARDS is important to identify novel therapeutic target and improve t...

    Authors: Yongqin Yan, Jianuo Chen, Qian Liang, Hong Zheng, Yiru Ye, Wengang Nan, Xi Zhang, Hongchang Gao and Yuping Li
    Citation: Respiratory Research 2022 23:172
  45. Few data exist on high flow nasal cannula (HFNC) use in patients with acute respiratory failure (ARF) admitted to general wards.

    Authors: Sebastiano Maria Colombo, Vittorio Scaravilli, Andrea Cortegiani, Nadia Corcione, Amedeo Guzzardella, Luca Baldini, Elisa Cassinotti, Ciro Canetta, Stefano Carugo, Cinzia Hu, Anna Ludovica Fracanzani, Ludovico Furlan, Maria Chiara Paleari, Alessandro Galazzi, Paola Tagliabue, Flora Peyvandi…
    Citation: Respiratory Research 2022 23:171
  46. Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD)...

    Authors: M. C. Schimmelpennink, D. B. Meek, A. D. M. Vorselaars, L. C. M. Langezaal, C. H. M. van Moorsel, J. J. van der Vis, M. Veltkamp and J. C. Grutters
    Citation: Respiratory Research 2022 23:169
  47. Studies of the respiratory tract microbiome primarily focus on airway and lung microbial diversity, but it is still unclear how these microbial communities may be affected by intubation and long periods in int...

    Authors: Erika Alejandra Cifuentes, Maria A. Sierra, Andrés Felipe Yepes, Ana Margarita Baldión, José Antonio Rojas, Carlos Arturo Álvarez-Moreno, Juan Manuel Anzola, María Mercedes Zambrano and Monica G. Huertas
    Citation: Respiratory Research 2022 23:168
  48. Cough strength is associated with short-term outcome in patients with scheduled extubation who successfully complete a spontaneous breathing trial (SBT). However, the long-term outcome is unclear.

    Authors: Yueling Hong, Min Deng, Wenhui Hu, Rui Zhang, Lei Jiang, Linfu Bai and Jun Duan
    Citation: Respiratory Research 2022 23:166

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