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  1. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory ...

    Authors: Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe…

    Citation: Respiratory Research 2018 19:71

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  2. Content type: Research

    Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death...

    Authors: L. Torre-Bouscoulet, W. R. Muñoz-Montaño, D. Martínez-Briseño, F. J. Lozano-Ruiz, R. Fernández-Plata, J. A. Beck-Magaña, C. García-Sancho, A. Guzmán-Barragán, E. Vergara, M. Blake-Cerda, L. Gochicoa-Rangel, F. Maldonado, M. Arroyo-Hernández and O. Arrieta

    Citation: Respiratory Research 2018 19:72

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  3. Content type: Research

    Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possibl...

    Authors: Olga Rafikova, Anup Srivastava, Ankit A. Desai, Ruslan Rafikov and Stevan P. Tofovic

    Citation: Respiratory Research 2018 19:69

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  4. Content type: Research

    Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and...

    Authors: Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord and Lena Gustavsson

    Citation: Respiratory Research 2018 19:68

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  5. Content type: Research

    In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we...

    Authors: Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg and Claudia A. Staab-Weijnitz

    Citation: Respiratory Research 2018 19:67

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  6. Content type: Letter to the Editor

    Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternativ...

    Authors: Elena Mitsi, Raphael Kamng’ona, Jamie Rylance, Carla Solórzano, J. Jesus Reiné, Henry C. Mwandumba, Daniela M. Ferreira and Kondwani C. Jambo

    Citation: Respiratory Research 2018 19:66

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  7. Content type: Research

    Corticosteroids increase the expression of β2-adrenoceptors (β2-ARs) and protect them against down-regulation. Conversely, β2-AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it ...

    Authors: Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola and Paola Rogliani

    Citation: Respiratory Research 2018 19:65

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  8. Content type: Research

    The imbalance between proteases and anti-proteases is considered to contribute to the development of COPD. Our aim was to evaluate the protease MMP-9, the antiprotease TIMP-1 and the MMP-9/TIMP-1-ratio as biom...

    Authors: Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie F. Behndig, Anders Blomberg and Anne Lindberg

    Citation: Respiratory Research 2018 19:64

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  9. Content type: Research

    Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencin...

    Authors: James D. Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson and Alicia Gayle

    Citation: Respiratory Research 2018 19:63

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  10. Content type: Research

    Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypo...

    Authors: Alejandro A. Diaz, Carlos H. Martinez, Rola Harmouche, Thomas P. Young, Merry-Lynn McDonald, James C. Ross, Mei Lan Han, Russell Bowler, Barry Make, Elizabeth A. Regan, Edwin K. Silverman, James Crapo, Aladin M. Boriek, Gregory L. Kinney, John E. Hokanson, Raul San Jose Estepar…

    Citation: Respiratory Research 2018 19:62

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  11. Content type: Research

    Chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in world. Cigarette smoke is known to cause oxidative stress and deplete glutathione (GSH) levels. Nuclear erythroid-rel...

    Authors: Mahin Dianat, Maryam Radan, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati and Masoumeh Ahmadizadeh

    Citation: Respiratory Research 2018 19:58

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  12. Content type: Research

    Gastric contents aspiration in humans has variable consequences depending on the volume of aspirate, ranging from subclinical pneumonitis to respiratory failure with up to 70% mortality. Several experimental a...

    Authors: Pedro Ayala, Jorge Torres, Raúl Vivar, Manuel Meneses, Pablo Olmos, Tamara San Martin and Gisella R. Borzone

    Citation: Respiratory Research 2018 19:57

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  13. Content type: Research

    Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the gene...

    Authors: Ma’en Obeidat, Guohai Zhou, Xuan Li, Nadia N. Hansel, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré and Don D. Sin

    Citation: Respiratory Research 2018 19:59

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  14. Content type: Research

    Obstructive sleep apnea (OSA) is highly prevalent in patients with coronary artery disease (CAD) and is associated with recurrent cardiovascular risk. However, whether treatment with continuous positive airway...

    Authors: Xiao Wang, Ying Zhang, Zhimin Dong, Jingyao Fan, Shaoping Nie and Yongxiang Wei

    Citation: Respiratory Research 2018 19:61

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  15. Content type: Research

    It is unknown if the plasma lipidome is a useful tool for improving our understanding of the acute respiratory distress syndrome (ARDS). Therefore, we measured the plasma lipidome of individuals with ARDS at t...

    Authors: Michael D. Maile, Theodore J. Standiford, Milo C. Engoren, Kathleen A. Stringer, Elizabeth S. Jewell, Thekkelnaycke M. Rajendiran, Tanu Soni and Charles F. Burant

    Citation: Respiratory Research 2018 19:60

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  16. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to e...

    Authors: Maxine J. Roberts, Rebecca E. Broome, Toby C. Kent, Steven J. Charlton and Elizabeth M. Rosethorne

    Citation: Respiratory Research 2018 19:56

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  17. Content type: Research

    A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, th...

    Authors: Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier and Henrik Watz

    Citation: Respiratory Research 2018 19:55

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  18. Content type: Research

    Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway sm...

    Authors: Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala and Kentaro Mizuta

    Citation: Respiratory Research 2018 19:53

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  19. Content type: Review

    In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered i...

    Authors: Alexandra McCarron, Martin Donnelley and David Parsons

    Citation: Respiratory Research 2018 19:54

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  20. Content type: Research

    Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the ...

    Authors: Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He and Depeng Jiang

    Citation: Respiratory Research 2018 19:47

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  21. Content type: Research

    Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be ...

    Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2018 19:52

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  22. Content type: Review

    Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative st...

    Authors: Alessandro G. Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A. Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru and Angelo Zinellu

    Citation: Respiratory Research 2018 19:51

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  23. Content type: Research

    Patients with chronic obstructive pulmonary disease (COPD) experience symptoms that vary over the day. Symptoms at the start of the day might influence physical activity during the rest of the day. Therefore, ...

    Authors: Amanda R. van Buul, Marise J. Kasteleyn, Niels H. Chavannes and Christian Taube

    Citation: Respiratory Research 2018 19:49

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