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  1. Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may e...

    Authors: Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro and Chantal Donovan
    Citation: Respiratory Research 2023 24:32
    Content type: Research Published on:

  2. Chronic obstructive pulmonary disease (COPD) varies significantly in symptomatic and physiologic presentation. Identifying disease subtypes from molecular data, collected from easily accessible blood samples, ...

    Authors: Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor…
    Citation: Respiratory Research 2023 24:30
    Content type: Research Published on:

  3. Pulmonary Rehabilitation (PR) is one of the most cost-effective therapies for chronic obstructive pulmonary disease (COPD) management. There are, however, people who do not respond to PR and reasons for non-re...

    Authors: Sara Melo-Dias, Miguel Cabral, Andreia Furtado, Sara Souto-Miranda, Maria Aurora Mendes, João Cravo, Catarina Rodrigues Almeida, Alda Marques and Ana Sousa
    Citation: Respiratory Research 2023 24:29
    Content type: Original Paper Published on:

  4. The Mesenchymal epithelial transition factor (MET) gene encodes a receptor tyrosine kinase with pleiotropic functions in cancer. MET exon 14 skipping alterations and high-level MET amplification are oncogenic and...

    Authors: Yu Yao, Huaping Yang, Bo Zhu, Song Wang, Jiaohui Pang, Xiaoying Wu, Yang Xu, Junli Zhang, Jinfeng Zhang, Qiuxiang Ou, Hui Tian and Zheng Zhao
    Citation: Respiratory Research 2023 24:28
    Content type: Research Published on:

  6. Severe bronchiolitis is often associated with subsequent respiratory morbidity, mainly recurrent wheezing and asthma. However, the underlying immune mechanisms remain unclear. The main goal of this study was t...

    Authors: Maria Luz Garcia-Garcia, Beatriz Sastre, Maria Arroyas, Maite Beato, Patricia Alonso, José Manuel Rodrigo-Muñoz, Victoria Del Pozo, Inmaculada Casas and Cristina Calvo
    Citation: Respiratory Research 2023 24:26
    Content type: Research Published on:

  7. Radiation-induced lung injury (RILI) is the most common and serious complication of chest radiotherapy. However, reported radioprotective agents usually lead to radiation resistance in tumor cells. The key to ...

    Authors: Xinrui Rao, Dong Zhou, Huilin Deng, Yunshang Chen, Jian Wang, Xiaoshu Zhou, Xiaohua Jie, Yingzhuo Xu, Zilong Wu, Geng Wang, Xiaorong Dong, Sheng Zhang, Rui Meng, Chuangyan Wu, Shijie Xing, Kai Fan…
    Citation: Respiratory Research 2023 24:25
    Content type: Research Published on:

  8. Advanced glycation end product receptor (RAGE) acts as a receptor of pro-inflammatory ligands and is highly expressed in alveolar epithelial cells (AECs). Autophagy in AECs has received much attention recently...

    Authors: Xi Xiong, Jiaying Dou, Jingyi Shi, Yuqian Ren, Chunxia Wang, Yucai Zhang and Yun Cui
    Citation: Respiratory Research 2023 24:24
    Content type: Research Published on:

  9. Low-dose spiral computed tomography (LDCT) may not lead to a clear treatment path when small to intermediate-sized lung nodules are identified. We have combined flow cytometry and machine learning to develop a...

    Authors: Madeleine E. Lemieux, Xavier T. Reveles, Jennifer Rebeles, Lydia H. Bederka, Patricia R. Araujo, Jamila R. Sanchez, Marcia Grayson, Shao-Chiang Lai, Louis R. DePalo, Sheila A. Habib, David G. Hill, Kathleen Lopez, Lara Patriquin, Robert Sussman, Roby P. Joyce and Vivienne I. Rebel
    Citation: Respiratory Research 2023 24:23
    Content type: Research Published on:

  10. Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown p...

    Authors: Dennis Kruk, Anna C. Y. Yeung, Alen Faiz, Nick H. T. ten Hacken, Wim Timens, Toin H. van Kuppevelt, Willeke Daamen, Danique Hof, Martin C. Harmsen, Mauricio Rojas and Irene H. Heijink
    Citation: Respiratory Research 2023 24:22
    Content type: Research Published on:

  11. Receptor for Advanced Glycated Endproducts (RAGE) plays a major role in the inflammatory response to infectious and toxin induced acute lung injury. We tested the hypothesis that a RAGE blocking antibody when ...

    Authors: Lynne L. Johnson, Yared Tekabe, Tina Zelonina, Xinran Ma, Geping Zhang, Monica Goldklang and Jeanine D’Armiento
    Citation: Respiratory Research 2023 24:21
    Content type: Research Published on:

  12. Parameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association between MEFVC shape and phenotypes like emphysema, small airways disease ...

    Authors: Kenneth Verstraete, Nilakash Das, Iwein Gyselinck, Marko Topalovic, Thierry Troosters, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Robert Jensen, Maarten De Vos and Wim Janssens
    Citation: Respiratory Research 2023 24:20
    Content type: Research Published on:

  13. The objective of the present study is to describe the characteristics of interstitial pneumonia with autoimmune features (IPAF) patients, to assess the incidence rate of functional respiratory impairment over ...

    Authors: Maria Asuncion Nieto, Olga Sanchez-Pernaute, Cristina Vadillo, Maria Jesus Rodriguez-Nieto, Fredeswinda Romero-Bueno, Belen López-Muñiz, Laura Cebrian, Maria Teresa Rio-Ramirez, Rosalia Laporta, Gema Bonilla, Tatiana Cobo, Leticia Leon and Lydia Abasolo
    Citation: Respiratory Research 2023 24:19
    Content type: Comment Published on:

  14. Epoprostenol AS (Veletri®), a thermostable epoprostenol formulation, provides better drug stability and improved clinical use compared to previous epoprostenol formulations. This study aims to expand clinical exp...

    Authors: Julia Degering, Benjamin Egenlauf, Satenik Harutyunova, Nicola Benjamin, Amina Salkić, Panagiota Xanthouli, Christina A. Eichstaedt, Rebekka Seeger, Olivier Sitbon and Ekkehard Grünig
    Citation: Respiratory Research 2023 24:18
    Content type: Research Published on:

  15. Molecular testing can detect actionable genomic alterations and tumor cell surface proteins in patients with non–small cell lung cancer (NSCLC). However, utilization remains suboptimal, representing missed tre...

    Authors: Florian J. Fintelmann, Nikki A. Martin, Ismail Tahir, Elissa M. Quinn, Timothy C. Allen, Lija Joseph, Boris Nikolic and Christopher Lee
    Citation: Respiratory Research 2023 24:17
    Content type: Research Published on:

  16. The level of linked N-acetylglucosamine (O-GlcNAc) has been proved to be a sensor of cell state, but its relationship with hyperoxia-induced alveolar type 2 epithelial cells injure and bronchopulmonary dysplas...

    Authors: Yu Xuefei, Liu Dongyan, Li Tianming, Zheng Hejuan and Fu Jianhua
    Citation: Respiratory Research 2023 24:16
    Content type: Research Published on:

  17. Chronic respiratory diseases are disorders of the airways and other structures of the lung, and include chronic obstructive pulmonary disease (COPD), lung cancer, asthma, bronchiectasis, interstitial lung dise...

    Authors: Gillian Sandra Gould, John R. Hurst, Antigona Trofor, Jennifer A. Alison, Gregory Fox, Muralidhar M. Kulkarni, Craig E. Wheelock, Marilyn Clarke and Ratika Kumar
    Citation: Respiratory Research 2023 24:15
    Content type: Comment Published on:

  18. The CaReQoL Asthma assesses the care-related quality of life outcomes of pulmonary rehabilitation retrospectively in patients with severe asthma. The questionnaire comprises five domains (physical functioning;...

    Authors: Linda Springvloet, Mattanja Triemstra, Bart Knottnerus, Marlon Rolink, Harry Heijerman and Dolf de Boer
    Citation: Respiratory Research 2023 24:14
    Content type: Research Published on:

  20. Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH) and causes adult pulmonary dysplasia. Systematic reviews have shown that some children with CH...

    Authors: Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye and Qi Sun
    Citation: Respiratory Research 2023 24:12
    Content type: Research Published on:

  21. Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity to Mycobacterium tuberculosis infection. However, th...

    Authors: Hung-Ling Huang, Yong-Chun Luo, Po-Liang Lu, Cheng-Hsieh Huang, Kun-Der Lin, Meng-Rui Lee, Meng-Hsuan Cheng, Yao-Tsung Yeh, Cheng-Yuan Kao, Jann-Yuan Wang, Jinn-Moon Yang and Inn-Wen Chong
    Citation: Respiratory Research 2023 24:11
    Content type: Research Published on:

  22. Due to the high transmissibility of SARS-CoV-2, accurate diagnosis is essential for effective infection control, but the gold standard, real-time reverse transcriptase-polymerase chain reaction (RT-PCR), is co...

    Authors: Eman Quraishi, Chiamaka Jibuaku, Daniil Lisik, Göran Wennergren, Jan Lötvall, Fredrik Nyberg, Linda Ekerljung, Madeleine Rådinger, Hannu Kankaanranta and Bright I. Nwaru
    Citation: Respiratory Research 2023 24:10
    Content type: Research Published on:

  23. We investigated the effects of vegetable glycerin (VG), a main e-cigarette constituent, on endotoxin-induced acute lung injury (ALI). Mice received intratracheal administration of 30% VG in phosphate buffered ...

    Authors: Vincent Yi-Fong Su, Wei-Chih Chen, Wen-Kuang Yu, Huai-Hsuan Wu, Hao Chen and Kuang-Yao Yang
    Citation: Respiratory Research 2023 24:9
    Content type: Research Published on:

  24. Lung fibroblast activation is associated with airway remodeling during asthma progression. Stearoyl-CoA desaturase 1 (SCD1) plays an important role in the response of fibroblasts to growth factors. This study ...

    Authors: Zili Zhou, Shixiu Liang, Zicong Zhou, Jieyi Liu, Jinming Zhang, Xiaojing Meng, Fei Zou, Haijin Zhao, Changhui Yu and Shaoxi Cai
    Citation: Respiratory Research 2023 24:8
    Content type: Research Published on:

  25. Several observational studies have found that idiopathic pulmonary fibrosis (IPF) is often accompanied by elevated circulating C-reactive protein (CRP) levels. However, the causal relationship between them rem...

    Authors: Kun Zhang, Anqi Li, Jiejun Zhou, Chaoguo Zhang and Mingwei Chen
    Citation: Respiratory Research 2023 24:7
    Content type: Research Published on:

  26. Systemic sclerosis (SSc) is a rare, complex, connective tissue disorder. Interstitial lung disease (ILD) is common in SSc, occurring in 35–52% of patients and accounting for 20–40% of mortality. Evolution of t...

    Authors: Franck F. Rahaghi, Vivien M. Hsu, Robert J. Kaner, Maureen D. Mayes, Ivan O. Rosas, Rajan Saggar, Virginia D. Steen, Mary E. Strek, Elana J. Bernstein, Nitin Bhatt, Flavia V. Castelino, Lorinda Chung, Robyn T. Domsic, Kevin R. Flaherty, Nishant Gupta, Bashar Kahaleh…
    Citation: Respiratory Research 2023 24:6
    Content type: Research Published on:

  27. Previous studies have revealed that sodium-restricted diet intervention significantly decreased apnea frequency among patients with sleep apnea. However, the longitudinal association between the habit of addin...

    Authors: Tingting Li, Lin Song, Guang Li, Fengping Li, Xiaoge Wang, Liangkai Chen, Shuang Rong and Li Zhang
    Citation: Respiratory Research 2023 24:5
    Content type: Research Published on:

  28. Authors: Yuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu…
    Citation: Respiratory Research 2023 24:4
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2022 23:314

  29. Allergic asthma is associated with airflow obstruction and hyper-responsiveness that arises from airway inflammation and remodeling. Cell therapy with mesenchymal stem cells (MSC) has been shown to attenuate i...

    Authors: Elga Bandeira, Su Chul Jang, Cecilia Lässer, Kristina Johansson, Madeleine Rådinger and Kyong-Su Park
    Citation: Respiratory Research 2023 24:3
    Content type: Research Published on:

  30. There is an interest in the role of blood eosinophils for predicting inhaled corticosteroid (ICS) response in chronic obstructive pulmonary disease (COPD). Most data are from interventional clinical studies; d...

    Authors: Heinrich Worth, Roland Buhl, Carl-Peter Criée, Peter Kardos, Eva Gückel and Claus F. Vogelmeier
    Citation: Respiratory Research 2023 24:2
    Content type: Correspondence Published on:

  31. Almitrine, a selective pulmonary vasoconstrictor in hypoxic area, improves oxygenation in mechanically ventilated patients with COVID-19 but its effects in spontaneously breathing patients with COVID-19 remain...

    Authors: Clément Saccheri, Lucas Morand, Marie Juston, Denis Doyen, Hervé Hyvernat, Romain Lombardi, Raphaël Devanlay, Émilie Panicucci, Jean Dellamonica and Mathieu Jozwiak
    Citation: Respiratory Research 2023 24:1
    Content type: Correspondence Published on:

  32. Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote epithelial-mesenchymal transition formation and to play a role in the p...

    Authors: Wun-Hao Cheng, Shih-Ya Kao, Chia-Ling Chen, Fara Silvia Yuliani, Lee-Yuan Lin, Chien-Huang Lin and Bing-Chang Chen
    Citation: Respiratory Research 2022 23:381
    Content type: Research Published on:

  33. Chronic obstructive pulmonary disease (COPD) is a progressive disorder that causes airway obstruction and lung inflammation. The first-line treatment of COPD is the bronchodilators of β2-agonists and antimusca...

    Authors: Di Liu, Wen Xu, Yuan Tang, Jingxue Cao, Ran Chen, Dingwei Wu, Hongpeng Chen, Bo Su and Jinfu Xu
    Citation: Respiratory Research 2022 23:380
    Content type: Research Published on:

  34. The interest in non-intubated video-assisted thoracic surgery (NIVATS) has risen over the last decade and numerous terms have been used to describe this technique. They all have in common, that the surgical pr...

    Authors: Matthias Grott, Martin Eichhorn, Florian Eichhorn, Werner Schmidt, Michael Kreuter and Hauke Winter
    Citation: Respiratory Research 2022 23:379
    Content type: Review Published on:

  36. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease that has no cure. Many current research efforts center on diagnostic and therapeutic modalities for IPF while other risk ...

    Authors: Aleksandr Kalininskiy, Ashley Rose Rackow, David Nagel, Daniel Croft, Heather McGrane-Minton and Robert Matthew Kottmann
    Citation: Respiratory Research 2022 23:377
    Content type: Research Published on:

  37. Non-tuberculous mycobacterial pulmonary disease (NTM-PD) poses a substantial patient, healthcare, and economic burden. Managing NTM-PD remains challenging, and factors contributing to this include morphologica...

    Authors: Roald van der Laan, Andy Snabilié and Marko Obradovic
    Citation: Respiratory Research 2022 23:376
    Content type: Review Published on:

  38. We recently reported in the phase 3 PANAMO trial that selectively blocking complement 5a (C5a) with vilobelimab led to improved survival in critically ill COVID-19 patients. C5a is an important contributor to ...

    Authors: Endry H. T. Lim, Alexander P. J. Vlaar, Lieuwe D. J. Bos, Lonneke A. van Vught, Anita M. Tuip-de Boer, Romein W. G. Dujardin, Maria Habel, Zhongli Xu, Matthijs C. Brouwer, Diederik van de Beek and Sanne de Bruin
    Citation: Respiratory Research 2022 23:375
    Content type: Correspondence Published on:

  39. Targeted lung cancer screening is effective in reducing mortality by upwards of twenty percent. However, screening is not universally available and uptake is variable and socially patterned. Understanding scre...

    Authors: Debbie Cavers, Mia Nelson, Jasmin Rostron, Kathryn A. Robb, Lynsey R. Brown, Christine Campbell, Ahsan R. Akram, Graeme Dickie, Melanie Mackean, Edwin J. R. van Beek, Frank Sullivan, Robert J. Steele, Aileen R. Neilson and David Weller
    Citation: Respiratory Research 2022 23:374
    Content type: Review Published on:

  41. To investigate the prognostic value of quantitative analysis of CT among patients with idiopathic pulmonary fibrosis (IPF) by quantifying the fibrosis extent and to attempt to provide precise medium-long term ...

    Authors: Kaifeng Du, Yichun Zhu, Ruolin Mao, Yubei Qu, Bo Cui, Yuan Ma, Xin Zhang and Zhihong Chen
    Citation: Respiratory Research 2022 23:372
    Content type: Research Published on:

  42. There is still insufficient knowledge with regard to the potential involvement of mast cells (MCs) and their mediators in the pathology of coronavirus disease-2019 (COVID-19). Therefore, our study aimed to inv...

    Authors: Andrey V. Budnevsky, Sergey N. Avdeev, Djuro Kosanovic, Victoria V. Shishkina, Andrey A. Filin, Dmitry I. Esaulenko, Evgeniy S. Ovsyannikov, Tatiana V. Samoylenko, Alexander N. Redkin, Olga A. Suvorova and Inna M. Perveeva
    Citation: Respiratory Research 2022 23:371
    Content type: Research Published on:

  44. Screening decreases mortality among lung cancer patients but is not widely implemented, thus there is an unmet need for an easily accessible non-invasive method to enable early diagnosis. Particles in exhaled ...

    Authors: Jesper Andreasson, Embla Bodén, Mohammed Fakhro, Camilla von Wachter, Franziska Olm, Malin Malmsjö, Oskar Hallgren and Sandra Lindstedt
    Citation: Respiratory Research 2022 23:369
    Content type: Research Published on:

  45. Hypersensitivity pneumonitis (HP) is a type of interstitial lung disease (ILD) with a variable disease course and prognosis ranging from inflammatory and self-limiting to irreversible and progressive pulmonary...

    Authors: Thomas Skovhus Prior, Julia Wälscher, Benjamin Gross, Elisabeth Bendstrup and Michael Kreuter
    Citation: Respiratory Research 2022 23:368
    Content type: Research Published on:

  46. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, whose pathogenetic complexity was strongly associated with aging/smoking and poorly understood.

    Authors: Qiqing Huang, Yuanyuan Wang, Lili Zhang, Wei Qian, Shaoran Shen, Jingshen Wang, Shuangshuang Wu, Wei Xu, Bo Chen, Mingyan Lin and Jianqing Wu
    Citation: Respiratory Research 2022 23:367
    Content type: Research Published on:

  47. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating respiratory disorder with high rates of mortality and morbidity, but the detailed underlying mechanisms of ALI/ARDS remain larg...

    Authors: Qi Jia, Yiyi Yang, Xiangdong Chen, Shanglong Yao and Zhiqiang Hu
    Citation: Respiratory Research 2022 23:366
    Content type: Review Published on:

  48. Bronchiectasis and bronchiolitis are differential diagnoses of asthma; moreover, they are factors associated with worse asthma control.

    Authors: Natsuko Nomura, Hisako Matsumoto, Akihito Yokoyama, Yoshihiro Nishimura, Koichiro Asano, Akio Niimi, Yuji Tohda, Norihiro Harada, Hiroyuki Nagase, Makoto Nagata, Hiromasa Inoue, Mitsuko Kondo, Takahiko Horiguchi, Nobuaki Miyahara, Nobuyuki Hizawa, Masayuki Hojo…
    Citation: Respiratory Research 2022 23:365
    Content type: Research Published on:

  49. β2-agonists provide necessary bronchodilatory action, are recommended by existing clinical practice guidelines and are widely prescribed for patients with these conditions. We examined the risk of all-cause mo...

    Authors: Joseph Emil Amegadzie, John-Michael Gamble, Jamie Farrell and Zhiwei Gao
    Citation: Respiratory Research 2022 23:364
    Content type: Correspondence Published on:

  50. Bronchiectasis is characterized by neutrophilic inflammation and frequent exacerbations often associated with infections. Lipid mediators play critical roles in the inflammatory response, and the balance betwe...

    Authors: Leonardo Terranova, Patrizia Risé, Andrea Gramegna, Christian Pinna, Carlo Agostoni, Marie-Louise Syrén, Stefano Turolo, Paola Marchisio, Francesco Amati, Stefano Aliberti, Angelo Sala and Francesco Blasi
    Citation: Respiratory Research 2022 23:363
    Content type: Research Published on:
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Respiratory Research

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