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  1. Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there is an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) and glycolipid m...

    Authors: Chenyang Li, Yu Peng, Xiaoyue Zhu, Yupu Liu, Jianyin Zou, Huaming Zhu, Xinyi Li, Hongliang Yi, Jian Guan, Xu Zhang, Huajun Xu and Shankai Yin
    Citation: Respiratory Research 2024 25:214
  2. Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions. Statins and proprotein co...

    Authors: Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee and Jung-Won Park
    Citation: Respiratory Research 2024 25:213
  3. Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whe...

    Authors: Youjia Yu, Chunyan Chu, Kang Wang, Yan Li, Zhengsheng Mao, Li Hu, Jie Wang, Yanfang Yu, Hao Sun and Feng Chen
    Citation: Respiratory Research 2024 25:212
  4. Bronchiectasis is a condition characterized by abnormal and irreversible bronchial dilation resulting from lung tissue damage and can be categorized into two main groups: cystic fibrosis (CF) and non-CF bronch...

    Authors: Heryk Motta, Júlia Catarina Vieira Reuwsaat, Fernanda Cortez Lopes, Graciele Viezzer, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Paulo de Tarso Roth Dalcin, Charley Christian Staats, Marilene Henning Vainstein and Lívia Kmetzsch
    Citation: Respiratory Research 2024 25:211
  5. Mitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in the pathogenesis of group 3 pulmonary hypertension (PH). And G protei...

    Authors: Ting Hu, Chaohui Mu, Yanmiao Li, Wanming Hao, Xinjuan Yu, Yixuan Wang, Wei Han and Qinghai Li
    Citation: Respiratory Research 2024 25:210
  6. Limited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients with post-acute sequelae of COVID-19 (PASC) especially dyspnea and fat...

    Authors: Po-Chun Lo, Jia-Yih Feng, Yi-Han Hsiao, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hsin-Kuo Ko and Diahn-Warng Perng
    Citation: Respiratory Research 2024 25:209
  7. We estimated the prevalence and mortality risks of preserved ratio impaired spirometry (PRISm) and chronic obstructive pulmonary disease (COPD) in the US adult population.

    Authors: Christopher J. Cadham, Hayoung Oh, MeiLan K. Han, David Mannino, Steven Cook, Rafael Meza, David T. Levy and Luz María Sánchez-Romero
    Citation: Respiratory Research 2024 25:208
  8. The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD an...

    Authors: N. Frantzi, X. P. Nguyen, C. Herr, P. Alter, S. Söhler, D. Soriano, H. Watz, B. Waschki, F. Trinkmann, M. Eichenlaub, F. C. Trudzinski, J. D. Michels-Zetsche, A. Omlor, F. Seiler, I. Moneke, F. Biertz…
    Citation: Respiratory Research 2024 25:207
  9. Previous studies have largely neglected the role of sulfur metabolism in LUAD, and no study has combine iron, copper, and sulfur-metabolism associated genes together to create prognostic signatures.

    Authors: Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu and Fancai Lai
    Citation: Respiratory Research 2024 25:206
  10. Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role...

    Authors: Li Zhu, Zhuhua Wu, Yingli Liu, Yue Ming, Pei Xie, Miao Jiang and Yong Qi
    Citation: Respiratory Research 2024 25:205
  11. The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear.

    Authors: Vincent Laiman, Hsiao-Chi Chuang, Yu-Chun Lo, Tzu-Hsuen Yuan, You-Yin Chen, Didik Setyo Heriyanto, Fara Silvia Yuliani, Kian Fan Chung and Jer-Hwa Chang
    Citation: Respiratory Research 2024 25:204
  12. Although electronic nose (eNose) has been intensively investigated for diagnosing lung cancer, cross-site validation remains a major obstacle to be overcome and no studies have yet been performed.

    Authors: Meng-Rui Lee, Mu-Hsiang Kao, Ya-Chu Hsieh, Min Sun, Kea-Tiong Tang, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih and Chong-Jen Yu
    Citation: Respiratory Research 2024 25:203
  13. Extracellular mitochondrial DNA (mtDNA) is released from damaged cells and increases in the serum and bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. While increased levels...

    Authors: Jun Fukihara, Koji Sakamoto, Yoshiki Ikeyama, Taiki Furukawa, Ryo Teramachi, Kensuke Kataoka, Yasuhiro Kondoh, Naozumi Hashimoto and Makoto Ishii
    Citation: Respiratory Research 2024 25:202
  14. Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and t...

    Authors: Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li and Mei Meng
    Citation: Respiratory Research 2024 25:201
  15. Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) remains a devastating clinical complication seriously affecting the therapeutic outcome of preterm infants. Hence, early prevention and tim...

    Authors: Dan Wang, Shuwei Huang, Jingke Cao, Zhichun Feng, Qiannan Jiang, Wanxian Zhang, Jia Chen, Shelby Kutty, Changgen Liu, Wenyu Liao, Le Zhang, Guli Zhu, Wenhao Guo, Jie Yang, Lin Liu, Jingwei Yang…
    Citation: Respiratory Research 2024 25:199
  16. The association between tuberculous fibrosis and lung cancer development has been reported by some epidemiological and experimental studies; however, its underlying mechanisms remain unclear, and the role of m...

    Authors: Seong Ji Woo, Youngmi Kim, Hyun-Jung Kang, Harry Jung, Dong Hyuk Youn, Yoonki Hong, Jae Jun Lee and Ji Young Hong
    Citation: Respiratory Research 2024 25:198
  17. OSA is a known medical condition that is associated with several comorbidities and affect patients’ quality of life. The association between OSA and lung cancer remains debated. Some studies reported increased...

    Authors: Mohamed H. Zidan, Hany M. Shaarawy, Heba S. Gharraf, Suzan F. Helal, Maged Hassan and Rana Rizk
    Citation: Respiratory Research 2024 25:197
  18. The treatment response to corticosteroids in patients with sarcoidosis is highly variable. CD4+ T cells are central in sarcoid pathogenesis and their phenotype in peripheral blood (PB) associates with disease cou...

    Authors: Jelle R. Miedema, Lieke J. de Jong, Vivienne Kahlmann, Ingrid M. Bergen, Caroline E. Broos, Marlies S. Wijsenbeek, Rudi W. Hendriks and Odilia B. J. Corneth
    Citation: Respiratory Research 2024 25:196
  19. Lipocalin-2 (LCN2) is a secretory glycoprotein upregulated by oxidative stress; moreover, patients with idiopathic pulmonary fibrosis (IPF) have shown increased LCN2 levels in bronchoalveolar lavage fluid (BAL...

    Authors: Hiroki Tanahashi, Hiroshi Iwamoto, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori
    Citation: Respiratory Research 2024 25:195
  20. Asthma is a common chronic disease amongst children. Epidemiological studies showed that the mortality rate of asthma in children is still high worldwide. Asthma control is therefore essential to minimize asth...

    Authors: Phillip L.W. Au-Doung, Jason C.H. Chan, Oliver Y.H. Kui, Marco K.Y. Ho, Yin Ting Cheung, Jenny K.W. Lam, Hak-Kim Chan, John Brannan, Kate C.C. Chan, Albert M. Li and Sharon S.Y. Leung
    Citation: Respiratory Research 2024 25:194
  21. Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) ...

    Authors: Niccolette Schaunaman, Diana Cervantes, Taylor Nichols, Mari Numata, Julie G. Ledford, Monica Kraft and Hong Wei Chu
    Citation: Respiratory Research 2024 25:193
  22. Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU)....

    Authors: David Drummond, Charlotte Roy, Matthieu Cornet, Julie Bucher, Véronique Boussaud, Françoise Le Pimpec-Barthes, Margaux Pontailler, Olivier Raisky, Vanessa Lopez, Claudio Barbanti, Romain Guillemain, Sylvain Renolleau, Marion Grimaud, Mehdi Oualha, Laure de Saint Blanquat and Isabelle Sermet-Gaudelus
    Citation: Respiratory Research 2024 25:190
  23. Idiopathic pulmonary fibrosis (IPF) is a debilitating and progressive lung disease of unknown aetiology, characterized by the relentless deposition of fibrotic tissue. Biomarkers may play a pivotal role as ind...

    Authors: Fabio Perrotta, Vito D’Agnano, Domenica Francesca Mariniello, Giuseppe Castaldo, Maria Vitale, Mario Cazzola, Andrea Bianco and Filippo Scialò
    Citation: Respiratory Research 2024 25:189
  24. Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by t...

    Authors: Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O’Kane, Brian Button, Lorcan P. McGarvey and Fionnuala T. Lundy
    Citation: Respiratory Research 2024 25:188
  25. Modulator therapies that seek to correct the underlying defect in cystic fibrosis (CF) have revolutionized the clinical landscape. Given the heterogeneous nature of lung disease progression in the post-modulat...

    Authors: Grace C. Zhou, Ziyun Wang, Anushka K. Palipana, Eleni-Rosalina Andrinopoulou, Pedro Miranda Afonso, Gary L. McPhail, Christopher M. Siracusa, Emrah Gecili and Rhonda D. Szczesniak
    Citation: Respiratory Research 2024 25:187
  26. Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol...

    Authors: Meng-Meng Xu, Jia-Ying Kang, Qiu-Yan Wang, Xing Zuo, Yuan-Yuan Tan, Yuan-Yuan Wei, Da-Wei Zhang, Ling Zhang, Hui-Mei Wu and Guang-He Fei
    Citation: Respiratory Research 2024 25:186
  27. The mechanisms by which cigarette smoking increases the risk of respiratory disease have been studied. However, less is known about risks of respiratory symptoms and outcomes associated with smoking cigars, an...

    Authors: Eva Sharma, Kristin Lauten, Katarzyna A. Zebrak, Kathryn C. Edwards, Samantha VanEtten, Adam F. Benson, Cristine D. Delnevo, Daniela Marshall, Heather L. Kimmel, Kristie A. Taylor, Maansi Bansal-Travers, Andrew Hyland and K. Michael Cummings
    Citation: Respiratory Research 2024 25:185
  28. In conventional practice, the left double lumen tube (DLT) is rotated 90° counterclockwise when the endobronchial cuff passes glottis. Success rate upon the first attempt is < 80%, likely owing to varying morp...

    Authors: Huiying Zhou, Yuda Fei, Yuelun Zhang, Xiang Quan and Jie Yi
    Citation: Respiratory Research 2024 25:184
  29. Previous studies have indicated that neutrophil extracellular traps (NETs) play a pivotal role in pathogenesis of pulmonary arterial hypertension (PAH). However, the specific mechanism underlying the impact of...

    Authors: Hongxiao Sun, Zhanhui Du, Xu Zhang, Shuai Gao, Zhixian Ji, Gang Luo and Silin Pan
    Citation: Respiratory Research 2024 25:183
  30. Asthma stands as one of the most prevalent chronic respiratory conditions in children, with its pathogenesis tied to the actived antigen presentation by dendritic cells (DCs) and the imbalance within T cell su...

    Authors: JinYing Xiang, Bo Liu, Yan Li, Yinying Ren, Yuehan Li, Mi Zhou, Jinyue Yu, Zhengxiu Luo, Enmei Liu, Zhou Fu and Fengxia Ding
    Citation: Respiratory Research 2024 25:182
  31. Extrachromosomal circular DNAs (eccDNAs) have been reported to play a key role in the occurrence and development of various diseases. However, the characterization and role of eccDNAs in pulmonary arterial hyp...

    Authors: Chun Zhang, Qiang Du, Xiao Zhou, Tianyu Qu, Yingying Liu, Kai Ma, Ziling Shen, Qun Wang, Zaikui Zhang and Ruifeng Zhang
    Citation: Respiratory Research 2024 25:181
  32. Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mut...

    Authors: Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto…
    Citation: Respiratory Research 2024 25:180
  33. Prolonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning and extubation is essential. Electrical Impedance Tomography (EIT) is a ...

    Authors: Jantine J. Wisse, Tom G. Goos, Annemijn H. Jonkman, Peter Somhorst, Irwin K. M. Reiss, Henrik Endeman and Diederik Gommers
    Citation: Respiratory Research 2024 25:179
  34. Severe asthma is associated with an increased risk for exacerbations, reduced lung function, fixed airflow obstruction, and substantial morbidity and mortality. The concept of remission in severe asthma as a n...

    Authors: Inês Farinha and Liam G Heaney
    Citation: Respiratory Research 2024 25:178
  35. Computer Aided Lung Sound Analysis (CALSA) aims to overcome limitations associated with standard lung auscultation by removing the subjective component and allowing quantification of sound characteristics. In ...

    Authors: Eline Lauwers, Toon Stas, Ian McLane, Annemiek Snoeckx, Kim Van Hoorenbeeck, Wilfried De Backer, Kris Ides, Jan Steckel and Stijn Verhulst
    Citation: Respiratory Research 2024 25:177
  36. Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased...

    Authors: Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang and Guoying Yu
    Citation: Respiratory Research 2024 25:176
  37. Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was...

    Authors: James W. Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S. Freeman, Tobias Hofving, Emil Ivarsson, Sara J. Bonvini, Wayne Brailsford, Linda Yrlid, Maria G. Belvisi and Mark A. Birrell
    Citation: Respiratory Research 2024 25:175
  38. Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. Howeve...

    Authors: Rongjun Wan, Prakhyath Srikaram, Shaobing Xie, Qiong Chen, Chengping Hu, Mei Wan, Yuanyuan Li and Peisong Gao
    Citation: Respiratory Research 2024 25:174
  39. Our understanding of airway dysbiosis in chronic obstructive pulmonary disease (COPD) remains incomplete, which may be improved by unraveling the complexity in microbial interactome.

    Authors: Wei Xiao, Yi-long Chen, Long-yi Du, Jiqiu Wu, Zhang Wang, Bing Mao, Fu-qiang Wen, Peter Gerard Gibson, Vanessa M. McDonald, Haopeng Yu and Juan-juan Fu
    Citation: Respiratory Research 2024 25:173
  40. The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung dysfunct...

    Authors: Huy Q. Ta, Maniselvan Kuppusamy, Swapnil K. Sonkusare, Mark E. Roeser and Victor E. Laubach
    Citation: Respiratory Research 2024 25:172
  41. Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopt...

    Authors: Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen and Xiaoyu Zhang
    Citation: Respiratory Research 2024 25:171
  42. While the COVID-19 outbreak and its complications are still under investigation, post-inflammatory pulmonary fibrosis (PF) has already been described as a long-term sequela of acute respiratory distress syndro...

    Authors: Giulia Gazzaniga, Marta Voltini, Alessandro Carletti, Elisa Lenta, Federica Meloni, Domenica Federica Briganti, Maria Antonietta Avanzini, Patrizia Comoli and Mirko Belliato
    Citation: Respiratory Research 2024 25:170
  43. To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC).

    Authors: Shanshan Niu, Tongyangzi Zhang, Wanzhen Li, Siwan Wen, Lei Dong, Shengyuan Wang, Wenbo Shi, Cuiqin Shi, Yuqin Shen, Qianchun Huang, Yaling Tan, Xianghuai Xu and Li Yu
    Citation: Respiratory Research 2024 25:169
  44. The COVID-19 pandemic has increased the incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, a comparison of VAP incidence in COVID-19 and non-COVID-19 cohorts, particular...

    Authors: Giorgia Montrucchio, Eleonora Balzani, Gabriele Sales, Anna Vaninetti, Francesca Grillo, Anna Chiara Trompeo, Marinella Zanierato, Vito Fanelli, Silvia Corcione, Francesco Giuseppe De Rosa, Antonio Curtoni, Cristina Costa and Luca Brazzi
    Citation: Respiratory Research 2024 25:168
  45. Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it is identified early and managed effectively. This study aims to develop an advanced COPD diagnostic m...

    Authors: Zecheng Zhu, Shunjin Zhao, Jiahui Li, Yuting Wang, Luopiao Xu, Yubing Jia, Zihan Li, Wenyuan Li, Gang Chen and Xifeng Wu
    Citation: Respiratory Research 2024 25:167
  46. Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, pr...

    Authors: Raisa Kraaijvanger, Montse Janssen Bonás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn and Coline H. M. van Moorsel
    Citation: Respiratory Research 2024 25:166
  47. Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a uniq...

    Authors: Jingyuan Gao, Yuqiong Yang, Xiaopeng Xiang, Huimin Zheng, Xinzhu Yi, Fengyan Wang, Zhenyu Liang, Dandan Chen, Weijuan Shi, Lingwei Wang, Di Wu, Shengchuan Feng, Qiaoyun Huang, Xueping Li, Wensheng Shu, Rongchang Chen…
    Citation: Respiratory Research 2024 25:165

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  • 2022 Citation Impact
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