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  1. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic options. Curdione, a sesquiterpene ...

    Authors: Peng Liu, Kang Miao, Lei Zhang, Yong Mou, Yongjian Xu, Weining Xiong, Jun Yu and Yi Wang

    Citation: Respiratory Research 2020 21:58

    Content type: Research

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  2. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are characterized by uncontrolled activati...

    Authors: Gali Epstein Shochet, Elizabetha Brook, Becky Bardenstein-Wald and David Shitrit

    Citation: Respiratory Research 2020 21:56

    Content type: Research

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  3. Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients.

    Authors: Eleanor L. Axson, Kishan Ragutheeswaran, Varun Sundaram, Chloe I. Bloom, Alex Bottle, Martin R. Cowie and Jennifer K. Quint

    Citation: Respiratory Research 2020 21:54

    Content type: Review

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  4. Persistent pulmonary hypertension of the newborn (PPHN) is characterized by sustained high levels of pulmonary vascular resistance after birth with etiology unclear; Arterial blood oxygen saturation of Tibetan...

    Authors: Mingbang Wang, Deyi Zhuang, Mei Mei, Haiyan Ma, Zixiu Li, Fusheng He, Guoqiang Cheng, Guang Lin and Wenhao Zhou

    Citation: Respiratory Research 2020 21:53

    Content type: Research

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  5. Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT resp...

    Authors: Annika W. M. Goorsenberg, Julia N. S. d’Hooghe, Annelies M. Slats, Joost G. van den Aardweg, Jouke T. Annema and Peter I. Bonta

    Citation: Respiratory Research 2020 21:52

    Content type: Research

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  6. The risk of tuberculosis (TB) in patients with impaired kidney function remains unclear by different stages of renal function impairment.

    Authors: Chin-Chung Shu, Yu-Feng Wei, Yi-Chun Yeh, Hsien-Ho Lin, Chung-Yu Chen, Ping-Huai Wang, Shih-Lung Cheng, Jann-Yuan Wang and Chong-Jen Yu

    Citation: Respiratory Research 2020 21:51

    Content type: Research

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  7. Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clini...

    Authors: Sundeep S. Salvi, Bill B. Brashier, Jyoti Londhe, Kanchan Pyasi, Vandana Vincent, Shilpa S. Kajale, Sajid Tambe, Kuldeep Mandani, Arjun Nair, Sze Mun Mak, Sapna Madas, Sanjay Juvekar, Louise E. Donnelly and Peter J. Barnes

    Citation: Respiratory Research 2020 21:50

    Content type: Research

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  8. Pragmatic use of the anti-fibrotic medications pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF) in the United States (US) has not been studied and may be different from international settings...

    Authors: Colin H. Holtze, Elizabeth A. Freiheit, Susan L. Limb, John L. Stauffer, Karina Raimundo, Wayne T. Pan, Kevin R. Flaherty and Hyun J. Kim

    Citation: Respiratory Research 2020 21:48

    Content type: Research

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  9. Many patients with chronic obstructive pulmonary disease (COPD) still experience daily symptoms, exacerbations, and accelerated lung function decline, even when receiving maximal combined treatment with inhale...

    Authors: Dave Singh, Fernando J. Martinez, Henrik Watz, Thomas Bengtsson and Brian T. Maurer

    Citation: Respiratory Research 2020 21:47

    Content type: Research

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  10. Female smokers have increased risk for chronic obstructive pulmonary disease (COPD) compared with male smokers who have a similar history of cigarette smoke exposure. Tertiary lymphoid follicles are often foun...

    Authors: Anthony Tam, Naoya Tanabe, Andrew Churg, Joanne L. Wright, James C. Hogg and Don D. Sin

    Citation: Respiratory Research 2020 21:46

    Content type: Research

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  11. Ventilator-associated pneumonia (VAP) is a significant cause of mortality in the intensive care unit. Early diagnosis of VAP is important to provide appropriate treatment and reduce mortality. Developing a non...

    Authors: Chung-Yu Chen, Wei-Chi Lin and Hsiao-Yu Yang

    Citation: Respiratory Research 2020 21:45

    Content type: Research

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  12. To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and female...

    Authors: Xiaoyue Ge, Tiantian Zhu, Xinyi Zhang, Ye Liu, Yonglong Wang and Weifang Zhang

    Citation: Respiratory Research 2020 21:44

    Content type: Research

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  13. The pathophysiology of congenital cystic adenomatoid malformations (CCAM) of the lung remains poorly understood.

    Authors: Guillaume Lezmi, Shamila Vibhushan, Claudia Bevilaqua, Nicolas Crapart, Nicolas Cagnard, Naziha Khen-Dunlop, Christine Boyle-Freyssaut, Alice Hadchouel and Christophe Delacourt

    Citation: Respiratory Research 2020 21:43

    Content type: Research

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  14. Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role ...

    Authors: Javier Lázaro, Paloma Clavería, Carmen Cabrejas, José Fernando, Berta Daga, Beatriz Ordoñez, Silvia Segura, David Sanz - Rubio and José M. Marín

    Citation: Respiratory Research 2020 21:42

    Content type: Study protocol

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  15. Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor perfor...

    Authors: Inken Padberg, Alice Schneider, Jessica Lee Rohmann, Sean Walter Kelley, Ulrike Grittner and Bob Siegerink

    Citation: Respiratory Research 2020 21:40

    Content type: Research

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  16. Recent studies have shown 6'-O-galloylpaeoniflorin (GPF), a nature product extracted from the roots of paeoniflorin exerts anti-oxidant and anti-inflammatory activities. However, the effects of GPF on the prol...

    Authors: Jinying Gao, Lei Song, Huan Xia, Liping Peng and Zhongmei Wen

    Citation: Respiratory Research 2020 21:39

    Content type: Research

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  17. Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a median survival of only three to 5 years. Fibroblast proliferation is a hallmark of IPF as is secretion of extracellular matrix proteins from...

    Authors: Tomohito Yoshihara, Yasuhiro Nanri, Satoshi Nunomura, Yukie Yamaguchi, Carol Feghali-Bostwick, Keiichi Ajito, Shoichi Murakami, Masaaki Mawatari and Kenji Izuhara

    Citation: Respiratory Research 2020 21:38

    Content type: Research

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  18. A persistent low inflammatory-oxidative status and the inadequacy of the antioxidant nuclear factor-E2-related factor 2 (Nrf2) have been implicated in chronic obstructive pulmonary disease (COPD) progression. ...

    Authors: A. M. Fratta Pasini, C. Stranieri, M. Ferrari, U. Garbin, L. Cazzoletti, C. Mozzini, F. Spelta, D. Peserico and L. Cominacini

    Citation: Respiratory Research 2020 21:37

    Content type: Research

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  19. In the Phase III INPULSIS® trials, treatment of patients with idiopathic pulmonary fibrosis (IPF) with nintedanib significantly reduced the annual rate of decline in forced vital capacity (FVC) versus placebo,...

    Authors: Michael Kreuter, Wim A. Wuyts, Marlies Wijsenbeek, Sabrina Bajwah, Toby M. Maher, Susanne Stowasser, Natalia Male, Wibke Stansen, Nils Schoof, Leticia Orsatti and Jeffrey Swigris

    Citation: Respiratory Research 2020 21:36

    Content type: Research

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  20. Obstructive sleep apnea syndrome (OSA) is currently recognized as an independent risk factor for hypertension, arrhythmia, coronary heart disease, stroke, and metabolic disorders (e.g. diabetes, dyslipidemia)....

    Authors: Stephanie André, Fabio Andreozzi, Chloé Van Overstraeten, Sidali Ben Youssef, Ionela Bold, Sarah Carlier, Alexia Gruwez, Anne-Violette Bruyneel and Marie Bruyneel

    Citation: Respiratory Research 2020 21:35

    Content type: Research

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  21. After publication of our article [1] the authors have notified us that one of the names has been incorrectly tagged.

    Authors: David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli and Paola Rottoli

    Citation: Respiratory Research 2020 21:34

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:6

  22. Interleukin 15 (IL-15) is a growth and modulating factor for B, T lymphocytes and natural killer cells (NK). Its action on innate and adaptive immunity is modulated by its alpha chain receptor (IL-15Rα). The I...

    Authors: Antoine Moui, Martin Klein, Dorian Hassoun, Eléonore Dijoux, Marie-Aude Cheminant, Antoine Magnan and Grégory Bouchaud

    Citation: Respiratory Research 2020 21:33

    Content type: Research

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  23. Fibrotic interstitial lung diseases (ILDs) are often challenging to diagnose and classify, but an accurate diagnosis has significant implications for both treatment and prognosis. A subset of patients with fib...

    Authors: Alyson W. Wong, Christopher J. Ryerson and Sabina A. Guler

    Citation: Respiratory Research 2020 21:32

    Content type: Review

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  24. Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a ...

    Authors: Michael J. McGeachie, Joanne E. Sordillo, Amber Dahlin, Alberta L. Wang, Sharon M. Lutz, Kelan G. Tantisira, Ronald Panganiban, Quan Lu, Satria Sajuthi, Cydney Urbanek, Rachel Kelly, Benjamin Saef, Celeste Eng, Sam S. Oh, Alvin T. Kho, Damien C. Croteau-Chonka…

    Citation: Respiratory Research 2020 21:31

    Content type: Research

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  25. Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molec...

    Authors: Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2020 21:30

    Content type: Research

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  26. After publication of our article [1], we have been notified that an extra alpha symbol (α) was mistakenly added at the beginning of the title.

    Authors: Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser and Manuela Funke-Chambour

    Citation: Respiratory Research 2020 21:29

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:25

  27. Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction be...

    Authors: K. Kahnert, M. Föhrenbach, T. Lucke, P. Alter, F. T. Trudzinski, R. Bals, J. I. Lutter, H. Timmermann, S. Söhler, S. Förderreuther, D. Nowak, H. Watz, B. Waschki, J. Behr, T. Welte, C. F. Vogelmeier…

    Citation: Respiratory Research 2020 21:28

    Content type: Research

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  28. Reduced physical capacity (PC) and physical activity (PA) are common in COPD patients and associated with poor outcome. However, they represent different aspects of physical functioning and interventions do no...

    Authors: Noriane A. Sievi, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jörg D. Leuppi, Robert Thurnheer, Malcolm Kohler and Christian F. Clarenbach

    Citation: Respiratory Research 2020 21:27

    Content type: Research

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  29. Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resti...

    Authors: Miguel J. Divo, Michael R. DePietro, John R. Horton, Cherie A. Maguire and Bartolome R. Celli

    Citation: Respiratory Research 2020 21:26

    Content type: Research

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  30. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy cells are well known and dru...

    Authors: Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser and Manuela Funke-Chambour

    Citation: Respiratory Research 2020 21:25

    Content type: Research

    Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:29

  31. Acute respiratory distress syndrome (ARDS), a complex response to various insults, has a high mortality rate. As pulmonary edema resulting from increased vascular permeability is a hallmark of ARDS, management...

    Authors: Yanfei Shen, Guolong Cai, Shangzhong Chen, Caibao Hu and Jing Yan

    Citation: Respiratory Research 2020 21:24

    Content type: Research

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  32. The aim of this study is investigating the benefits and harms of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS).

    Authors: Zhongjun Zheng, Libing Jiang, Song Zhang, Christophe Guervilly, Mao Zhang, Xia Feng and Jianbo Ding

    Citation: Respiratory Research 2020 21:23

    Content type: Research

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  33. Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of c...

    Authors: Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie and Xiao-feng Yan

    Citation: Respiratory Research 2020 21:22

    Content type: Research

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  34. For still unclear reasons, chronic airway infection often occurs in patients with Chronic Obstructive Pulmonary Disease (COPD), particularly in those with more severe airflow limitation. Fatty-acid binding pro...

    Authors: Lídia Perea, Ana Rodrigo-Troyano, Elisabet Cantó, Marisol Domínguez-Álvarez, Jordi Giner, Ferran Sanchez-Reus, Judit Villar-García, Sara Quero, Marian García-Núñez, Alicia Marín, Eduard Monsó, Rosa Faner, Alvar Agustí, Silvia Vidal and Oriol Sibila

    Citation: Respiratory Research 2020 21:21

    Content type: Research

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  35. The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of thi...

    Authors: Ryoung-Eun Ko, Jin Gu Lee, Song Yee Kim, Young Tae Kim, Sun Mi Choi, Do Hyung Kim, Woo Hyun Cho, Seung-Il Park, Kyung-Wook Jo, Hong Kwan Kim, Hyo Chae Paik and Kyeongman Jeon

    Citation: Respiratory Research 2020 21:20

    Content type: Research

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  36. Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment ...

    Authors: Christian Vogelberg, Stanley Goldstein, LeRoy Graham, Alan Kaplan, Alberto de la Hoz and Eckard Hamelmann

    Citation: Respiratory Research 2020 21:19

    Content type: Research

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  37. Recurrent bronchiectasis exacerbations are related to deterioration of lung function, progression of the disease, impairment of quality of life, and to an increased mortality. Improved detection of exacerbatio...

    Authors: Amaia Artaraz, Megan L. Crichton, Simon Finch, Hani Abo-Leyah, Pieter Goeminne, Stefano Aliberti, Thomas Fardon and James D. Chalmers

    Citation: Respiratory Research 2020 21:18

    Content type: Research

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  38. Clinically Important Deterioration (CID) is a novel composite measure to assess treatment effect in chronic obstructive pulmonary disease (COPD). We examined the performance and utility of CID in assessing the...

    Authors: Mona Bafadhel, Dave Singh, Christine Jenkins, Stefan Peterson, Thomas Bengtsson, Peter Wessman and Malin Fagerås

    Citation: Respiratory Research 2020 21:17

    Content type: Research

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  39. Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains ...

    Authors: Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma and Yan Zhao

    Citation: Respiratory Research 2020 21:16

    Content type: Research

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  40. Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiati...

    Authors: Gabriella H. Long, Thomas Southworth, Umme Kolsum, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Citation: Respiratory Research 2020 21:15

    Content type: Letter to the Editor

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  41. Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is li...

    Authors: Yifang Liao, Ping Li, Yanxia Wang, Hong Chen, Shangwei Ning and Dongju Su

    Citation: Respiratory Research 2020 21:14

    Content type: Research

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  42. This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC...

    Authors: Sumin Shin, Yong Soo Choi, Jae Jun Jung, Yunjoo Im, Sun Hye Shin, Danbee Kang, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Keunchil Park, Myung-Ju Ahn, Yong Chan Ahn, Genehee Lee, Juhee Cho…

    Citation: Respiratory Research 2020 21:13

    Content type: Research

    Published on:

  43. Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen. Prognostication in cHP remains challenging, and the relationsh...

    Authors: Julia Wälscher, Benjamin Gross, Julie Morisset, Kerri A. Johannson, Martina Vasakova, Jacques Bruhwyler and Michael Kreuter

    Citation: Respiratory Research 2020 21:12

    Content type: Research

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  44. Several registries of idiopathic pulmonary fibrosis (IPF) have been established to better understand its natural history, though their size and duration of follow-up are limited. Here, we describe the large Eu...

    Authors: Tanja Tran, Martina Šterclová, Nesrin Mogulkoc, Katarzyna Lewandowska, Veronika Müller, Marta Hájková, Mordechai R. Kramer, Dragana Jovanović, Jasna Tekavec-Trkanjec, Michael Studnicka, Natalia Stoeva, Karel Hejduk, Ladislav Dušek, Samy Suissa and Martina Vašáková

    Citation: Respiratory Research 2020 21:11

    Content type: Research

    Published on:

  45. Although cavities are an important finding in Mycobacterium avium complex pulmonary disease (MAC-PD), there is little information regarding the types of cavities that indicate disease progression. This study was ...

    Authors: Yohei Oshitani, Seigo Kitada, Ryuya Edahiro, Kazuyuki Tsujino, Hiroyuki Kagawa, Kenji Yoshimura, Keisuke Miki, Mari Miki and Hiroshi Kida

    Citation: Respiratory Research 2020 21:10

    Content type: Research

    Published on:

  46. High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mecha...

    Authors: Cuiping Fu, Shengyu Hao, Zilong Liu, Liang Xie, Xu Wu, Xiaodan Wu and Shanqun Li

    Citation: Respiratory Research 2020 21:9

    Content type: Research

    Published on:

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