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  1. Haemoptysis is a challenging symptom that can be associated with potentially life-threatening medical conditions. Follow-up is key in these patients to promptly detect new or misdiagnosed pathologic findings. ...

    Authors: Michele Mondoni, Paolo Carlucci, Giuseppe Cipolla, Matteo Pagani, Francesco Tursi, Alessandro Fois, Pietro Pirina, Sara Canu, Stefano Gasparini, Martina Bonifazi, Silvia Marani, Andrea Comel, Laura Saderi, Sabrina De Pascalis, Fausta Alfano, Stefano Centanni…

    Citation: Respiratory Research 2021 22:219

    Content type: Research

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  2. Treatments of interstitial lung diseases (ILDs) mainly focus on disease stabilization and relief of symptoms by managing inflammation or suppressing fibrosis by (in part costly) drugs. To highlight economic bu...

    Authors: Phillen Nozibuyiso Maqhuzu, Michael Kreuter, Thomas Bahmer, Nicolas Kahn, Martin Claussen, Rolf Holle and Larissa Schwarzkopf

    Citation: Respiratory Research 2021 22:218

    Content type: Research

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  3. Previous studies have shown inconsistent results regarding the impact of traffic pollution on the prevalence of chronic obstructive pulmonary disease (COPD). Therefore, using frequency matching and propensity ...

    Authors: Hui-Tsung Hsu, Chih-Da Wu, Mu-Chi Chung, Te-Chun Shen, Ting-Ju Lai, Chiu-Ying Chen, Ruey-Yun Wang and Chi-Jung Chung

    Citation: Respiratory Research 2021 22:217

    Content type: Research

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  4. Neutrophilic asthmatics (NA) have less response to inhaled corticosteroids. We aimed to find out the predictor of treatment response in NA.

    Authors: Shengding Zhang, Yu Fan, Lu Qin, Xiaoyu Fang, Cong Zhang, Junqing Yue, Wenxue Bai, Gang Wang, Zhihong Chen, Harld Renz, Chrysanthi Skevaki, Xiansheng Liu and Min Xie

    Citation: Respiratory Research 2021 22:216

    Content type: Research

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  5. Clinical course of pleuroparenchymal fibroelastosis (PPFE) shows considerable variation among patients, but there is no established prognostic prediction model for PPFE.

    Authors: Yoshiaki Kinoshita, Takato Ikeda, Takuto Miyamura, Yusuke Ueda, Yuji Yoshida, Hisako Kushima, Masaki Fujita, Takashi Ogura, Kentaro Watanabe and Hiroshi Ishii

    Citation: Respiratory Research 2021 22:215

    Content type: Research

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  6. We evaluated the effects of abrupt versus gradual PEEP decrease, combined with standard versus high-volume fluid administration, on cardiac function, as well as lung and kidney damage in an established model o...

    Authors: Nazareth N. Rocha, Cynthia S. Samary, Mariana A. Antunes, Milena V. Oliveira, Matheus R. Hemerly, Patrine S. Santos, Vera L. Capelozzi, Fernanda F. Cruz, John J. Marini, Pedro L. Silva, Paolo Pelosi and Patricia R. M. Rocco

    Citation: Respiratory Research 2021 22:214

    Content type: Research

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  7. Increasing evidence revealed that airway microbial dysbiosis was associated with increased risk of asthma, or persistent wheezing (PW). However, the role of lung microbiota in PW or wheezing recurrence remains...

    Authors: Lei Wu, Chencong Shen, Yuanling Chen, Xin Yang, Xiaofei Luo, Chengcheng Hang, Lingling Yan and Xuefeng Xu

    Citation: Respiratory Research 2021 22:213

    Content type: Research

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  8. Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal congenital lung disorder in neonates characterized by severe progressive respiratory failure and refractory pulmonary...

    Authors: Justyna A. Karolak, Tomasz Gambin, Przemyslaw Szafranski, Rebecca L. Maywald, Edwina Popek, Jason D. Heaney and Paweł Stankiewicz

    Citation: Respiratory Research 2021 22:212

    Content type: Research

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  9. Whether acute respiratory failure in patients with interstitial lung disease is reversible remains uncertain. Consequently, indications for extracorporeal membrane oxygenation in these patients are still contr...

    Authors: Yuko Usagawa, Kosaku Komiya, Mari Yamasue, Kiyohide Fushimi, Kazufumi Hiramatsu and Jun-ichi Kadota

    Citation: Respiratory Research 2021 22:211

    Content type: Research

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  10. Although cigarette smoking is a major risk factor for lung cancer, the incidence rate of lung cancer among non-smokers is notable. The etiology and potential mechanism of non-smoker lung cancer are worthy of f...

    Authors: Fanglin Yu, Rendong Xiao, Xu Li, Zhijian Hu, Lin Cai and Fei He

    Citation: Respiratory Research 2021 22:210

    Content type: Research

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  11. In some RCTs comparing triple therapy with dual therapy in COPD, there might be a bias resulting from the use of multiple inhaler devices. This meta-analysis included only RCTs that compared ICS/LABA/LAMA vs. ...

    Authors: Huanyu Long, Hongxuan Xu, Jean-Paul Janssens and Yanfei Guo

    Citation: Respiratory Research 2021 22:209

    Content type: Research

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  12. Very preterm infants are at high risk of developing chronic lung disease, which requires respiratory support and might have long-term sequelae. As lung inflammation plays an important role in pathogenesis, ant...

    Authors: Marlide Jukema, Franciszek Borys, Greta Sibrecht, Karsten Juhl Jørgensen and Matteo Bruschettini

    Citation: Respiratory Research 2021 22:208

    Content type: Review

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  13. Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In well-selected AATD patients, therapy with plasma-de...

    Authors: Katsuyuki Takeda, Soo-Hyun Kim, Anthony Joetham, Irina Petrache and Erwin W. Gelfand

    Citation: Respiratory Research 2021 22:207

    Content type: Research

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  14. Respiratory viral infections are one of the leading causes of need for emergency care and hospitalizations in asthmatic individuals, and airway-secreted cytokines are released within hours of viral infection t...

    Authors: Kristi J. Warren, Jill A. Poole, Jenea M. Sweeter, Jane M. DeVasure, John D. Dickinson, R. Stokes Peebles Jr and Todd A. Wyatt

    Citation: Respiratory Research 2021 22:206

    Content type: Research

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  15. Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function and a high mortality rate. Biomarkers measuring the...

    Authors: H. Jessen, N. Hoyer, T. S. Prior, P. Frederiksen, M. A. Karsdal, D. J. Leeming, E. Bendstrup, J. M. B. Sand and S. B. Shaker

    Citation: Respiratory Research 2021 22:205

    Content type: Research

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  16. Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells....

    Authors: Ailin Yang, Yanjun Wu, Ganggang Yu and Haoyan Wang

    Citation: Respiratory Research 2021 22:204

    Content type: Review

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  17. Thousands of Coronavirus Disease 2019 (COVID-19) patients have been discharged from hospitals Persistent follow-up studies are required to evaluate the prevalence of post-COVID-19 fibrosis.

    Authors: Xiaohe Li, Chenguang Shen, Lifei Wang, Sumit Majumder, Die Zhang, M. Jamal Deen, Yanjie Li, Ling Qing, Ying Zhang, Chuming Chen, Rongrong Zou, Jianfeng Lan, Ling Huang, Cheng Peng, Lijiao Zeng, Yanhua Liang…

    Citation: Respiratory Research 2021 22:203

    Content type: Research

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  18. The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use...

    Authors: Tao Chen, Amy Po Yu Tsai, Seo Am Hur, Alyson W. Wong, Mohsen Sadatsafavi, Jolene H. Fisher, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Shane Shapera, Nasreen Khalil, Charlene D. Fell, Helene Manganas, Gerard Cox, Teresa To, Andrea S. Gershon…

    Citation: Respiratory Research 2021 22:202

    Content type: Research

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  19. The effect of inhaled corticosteroids (ICS) on risk of hyperglycemia in patients with chronic obstructive pulmonary disease (COPD) remains ambiguous. The aim of this study is to evaluate the association betwee...

    Authors: Xiaofeng Pu, Liang Liu, Bimin Feng, Zhengji Zhang and Guojun Wang

    Citation: Respiratory Research 2021 22:201

    Content type: Review

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  20. The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter ...

    Authors: Sarah L. O’Beirne, Jacqueline Salit, Robert J. Kaner, Ronald G. Crystal and Yael Strulovici-Barel

    Citation: Respiratory Research 2021 22:200

    Content type: Research

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  21. Observational studies on the general population have suggested that airflow obstruction associates with left ventricular (LV) filling. To limit the influence of environmental risk factors/exposures, we used a ...

    Authors: Lars Harbaum, Jan K. Hennigs, Marcel Simon, Tim Oqueka, Henrik Watz and Hans Klose

    Citation: Respiratory Research 2021 22:199

    Content type: Research

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  22. Acute respiratory distress syndrome (ARDS) is multifactorial and can result from sepsis, trauma, or pneumonia, amongst other primary pathologies. It is one of the major causes of death in critically ill patien...

    Authors: Premila D. Leiphrakpam, Hannah R. Weber, Andrea McCain, Roser Romaguera Matas, Ernesto Martinez Duarte and Keely L. Buesing

    Citation: Respiratory Research 2021 22:198

    Content type: Research

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  23. Idiopathic pulmonary fibrosis (IPF) is a progressive debilitating lung disease with considerable morbidity. Heterogeneity in epidemiologic studies means the full impact of the disease is unclear.

    Authors: Toby M. Maher, Elisabeth Bendstrup, Louis Dron, Jonathan Langley, Gerald Smith, Javaria Mona Khalid, Haridarshan Patel and Michael Kreuter

    Citation: Respiratory Research 2021 22:197

    Content type: Research

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  24. Neonatal intermittent hypoxia (IH) results in oxidative distress in preterm infants with immature antioxidant systems, contributing to lung injury. Coenzyme Q10 (CoQ10) and fish oil protect against oxidative i...

    Authors: Christina D’Agrosa, Charles L. Cai, Faisal Siddiqui, Karen Deslouches, Stephen Wadowski, Jacob V. Aranda and Kay D. Beharry

    Citation: Respiratory Research 2021 22:196

    Content type: Research

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  25. We recently reported histone methyltransferase enhancer of zeste homolog 2 (EZH2) as a key epigenetic regulator that contributes to the dysfunction of innate immune responses to sepsis and subsequent lung inju...

    Authors: Xiaowei Bao, Xiandong Liu, Na Liu, Shougang Zhuang, Qian Yang, Huijuan Ren, Dongyang Zhao, Jianwen Bai, Xiaohui Zhou and Lunxian Tang

    Citation: Respiratory Research 2021 22:194

    Content type: Research

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  26. Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel macrophage-derived lip...

    Authors: Xin-Yang Wang, Xin-Yu Li, Cheng-Hua Wu, Yu Hao, Pan-Han Fu, Hong-Xia Mei, Fang Chen, Yu-Qiang Gong, Sheng-Wei Jin and Hui Li

    Citation: Respiratory Research 2021 22:193

    Content type: Research

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  27. To explore the role of family with sequence similarity 13 member A (FAM13A) in TGF-β1-induced EMT in the small airway epithelium of patients with chronic obstructive pulmonary disease (COPD).

    Authors: Jinyuan Zhu, Faxuan Wang, Xueyan Feng, Beibei Li, Liqiong Ma and Jin Zhang

    Citation: Respiratory Research 2021 22:192

    Content type: Research

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  28. For patients with chronic obstructive pulmonary disease (COPD), greater improvements in lung function have been demonstrated for triple versus dual inhaled therapies in traditional spirometry studies. This stu...

    Authors: Maarten van den Berge, Jan De Backer, Cedric Van Holsbeke, Wilfried De Backer, Roopa Trivedi, Martin Jenkins, Paul Dorinsky and Magnus Aurivillius

    Citation: Respiratory Research 2021 22:191

    Content type: Research

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  29. In this study, we tested whether a combination of radiomic features extracted from baseline pre-immunotherapy computed tomography (CT) images and clinicopathological characteristics could be used as novel noni...

    Authors: Bin Yang, Li Zhou, Jing Zhong, Tangfeng Lv  , Ang Li, Lu Ma, Jian Zhong, Saisai Yin, Litang Huang, Changsheng Zhou, Xinyu Li, Ying Qian Ge, Xinwei Tao, Longjiang Zhang, Yong Son and Guangming Lu

    Citation: Respiratory Research 2021 22:189

    Content type: Research

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  30. Xuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been widely used to treat a variety of respiratory diseases in China, especially to seriously infectious diseases such ...

    Authors: Huahe Zhu, Shun Wang, Cong Shan, Xiaoqian Li, Bo Tan, Qilong Chen, Yunxiang Yang, Hongji Yu and Aidong Yang

    Citation: Respiratory Research 2021 22:188

    Content type: Research

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  31. In the Phase III KRONOS study, triple therapy with budesonide/glycopyrronium/formoterol fumarate metered dose inhaler (BGF MDI) was shown to reduce exacerbations and improve lung function versus glycopyrronium...

    Authors: Shigeo Muro, Hisatoshi Sugiura, Patrick Darken and Paul Dorinsky

    Citation: Respiratory Research 2021 22:187

    Content type: Research

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  32. Bronchial thermoplasty regulates structural abnormalities involved in airway narrowing in asthma. In the present study we aimed to investigate the effect of bronchial thermoplasty on histopathological bronchia...

    Authors: Eleni Papakonstantinou, Triantafyllia Koletsa, Liang Zhou, Lei Fang, Michael Roth, Meropi Karakioulaki, Spasenija Savic, Leticia Grize, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2021 22:186

    Content type: Research

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  33. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, small vessel, necrotizing vasculitis. The disease is mainly characterized by hypereosinophilia and asthma with frequent sinonasal involvement, al...

    Authors: Aikaterini Detoraki, Eugenio Tremante, Remo Poto, Emanuela Morelli, Giuseppe Quaremba, Francescopaolo Granata, Antonio Romano, Ilaria Mormile, Francesca Wanda Rossi, Amato de Paulis and Giuseppe Spadaro

    Citation: Respiratory Research 2021 22:185

    Content type: Letter to the Editor

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  34. Severe asthma is associated with a broad range of phenotypes and clinical characteristics. This analysis assessed whether select baseline patient characteristics could prognosticate mepolizumab efficacy in sev...

    Authors: Catherine Lemiere, Camille Taillé, Jason Kihyuk Lee, Steven G. Smith, Stephen Mallett, Frank C. Albers, Eric S. Bradford, Steven W. Yancey and Mark C. Liu

    Citation: Respiratory Research 2021 22:184

    Content type: Research

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  35. Recently, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended for patients with COPD who have s...

    Authors: Akira Koarai, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama and Hisatoshi Sugiura

    Citation: Respiratory Research 2021 22:183

    Content type: Research

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  36. Sepsis may be accompanied by acute respiratory distress syndrome (ARDS) in patients admitted to intensive care units (ICUs). It is essential to identify prognostic biomarkers in patients with sepsis and ARDS.

    Authors: Xing Li, Hua Shen, Tinghong Zhou, Xiaoyu Cao, Ying Chen, Yan Liang, Ting Lu, Jiafen He, Zhoulin Dou, Chuankai Liu, Yong Tang and Zexiang Zhu

    Citation: Respiratory Research 2021 22:182

    Content type: Research

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  37. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease that leads to respiratory failure and death. Although there is a greater understanding of the etiology of this disease, accur...

    Authors: Takafumi Niwamoto, Tomohiro Handa, Yuko Murase, Yoshinari Nakatsuka, Kiminobu Tanizawa, Yoshio Taguchi, Hiromi Tomioka, Keisuke Tomii, Hideo Kita, Michihiro Uyama, Michiko Tsuchiya, Masahito Emura, Tetsuji Kawamura, Naoki Arai, Machiko Arita, Kazuko Uno…

    Citation: Respiratory Research 2021 22:181

    Content type: Research

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  38. Escalation to triple therapy (long-acting muscarinic antagonist/β2-agonist, inhaled corticosteroid [ICS]) in chronic obstructive pulmonary disorder (COPD) is recommended for patients on LAMA/LABA combinations wit...

    Authors: Shigeo Muro, Masaru Suzuki, Shuhei Nakamura, Jocelyn Ruoyi Wang, Elizabeth M. Garry, Wataru Sakamoto and Sabrina de Souza

    Citation: Respiratory Research 2021 22:180

    Content type: Research

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  39. Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known. The goal of t...

    Authors: Yuqing Mo, Ling Ye, Hui Cai, Guiping Zhu, Jian Wang, Mengchan Zhu, Xixi Song, Chengyu Yang and Meiling Jin

    Citation: Respiratory Research 2021 22:178

    Content type: Research

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  40. The course of asthma may differ between elderly asthmatics (EA) and non-elderly asthmatics (nEA), which may be partially associated with an age-dependent aberrant immune response. The aim of the study was to d...

    Authors: Aleksandra Wardzyńska, Małgorzata Pawełczyk, Joanna Rywaniak, Joanna Makowska, Joanna Jamroz-Brzeska and Marek L. Kowalski

    Citation: Respiratory Research 2021 22:177

    Content type: Research

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  41. Invasive pulmonary aspergillosis (IPA) is increasingly reported in chronic obstructive pulmonary disease (COPD) patients. These patients often have poor clinical outcomes. Early recognition of IPA in COPD is a...

    Authors: Yu Gu, Xianping Ye, Yuxiu Liu, Yu Wang, Kunlu Shen, Jinjin Zhong, Bilin Chen and Xin Su

    Citation: Respiratory Research 2021 22:176

    Content type: Research

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  42. Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes m...

    Authors: Le Bai, Li Zhang, Tingyu Pan, Wei Wang, Dian Wang, Cassidy Turner, Xianmei Zhou and Hailang He

    Citation: Respiratory Research 2021 22:175

    Content type: Research

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  43. Ventilator-associated pneumonia (VAP) is difficult to diagnose using clinical criteria and no biomarkers have yet been proved to be sufficiently accurate. The use of the neutrophil-derived Heparin-binding prot...

    Authors: Magnus Paulsson, Louise Thelaus, Kristian Riesbeck, Ingemar Qvarfordt, Margaretha E. Smith, Anders Lindén and Adam Linder

    Citation: Respiratory Research 2021 22:174

    Content type: Letter to the Editor

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  44. Respiratory fungal exposure is known to be associated with various allergic pulmonary disorders. Eosinophils have been implicated in tissue homeostasis of allergic inflammation as both destructive effector cel...

    Authors: Sijiao Wang, Zhilong Jiang, Liyang Li, Jun Zhang, Cuiping Zhang and Changzhou Shao

    Citation: Respiratory Research 2021 22:173

    Content type: Research

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  45. Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently,...

    Authors: Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E. G. W. Vanfleteren and Melker Göransson

    Citation: Respiratory Research 2021 22:172

    Content type: Research

    Published on:

  46. Comorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe as...

    Authors: Peter G. Gibson, Charlene M. Prazma, Geoffrey L. Chupp, Eric S. Bradford, Mark Forshag, Stephen A. Mallett, Steve W. Yancey, Steven G. Smith and Elisabeth H. Bel

    Citation: Respiratory Research 2021 22:171

    Content type: Research

    Published on:

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