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  1. Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways. Mucosal-associated invariant T (MAIT) cells are unconventiona...

    Authors: Terezia Pincikova, Tiphaine Parrot, Lena Hjelte, Marieann Högman, Karin Lisspers, Björn Ställberg, Christer Janson, Andrei Malinovschi and Johan K. Sandberg
    Citation: Respiratory Research 2022 23:127
  2. Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve...

    Authors: Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu and Rodney D. Britt Jr
    Citation: Respiratory Research 2022 23:126
  3. Blood transcriptomics can be used for confirmation of tuberculosis diagnosis or sputumless triage, and a comparison of their practical diagnostic accuracy is needed to assess their usefulness. In this study, w...

    Authors: Qian Qiu, Anzhou Peng, Yanlin Zhao, Dongxin Liu, Chunfa Liu, Shi Qiu, Jinhong Xu, Hongguang Cheng, Wei Xiong and Yaokai Chen
    Citation: Respiratory Research 2022 23:125
  4. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung condition. Currently, care models predominantly focus on acute medical and pharmacological needs. As a step towards holistic care, the aim ...

    Authors: Anouk Delameillieure, Fabienne Dobbels, Steffen Fieuws, Katleen Leceuvre, Sara Vanderauwera and Wim A. Wuyts
    Citation: Respiratory Research 2022 23:124
  5. Although immunotherapy has shown clinical activity in lung adenocarcinoma (LUAD), LUAD prognosis has been a perplexing problem. We aimed to construct an immune-related lncRNA pairs (IRLPs) score for LUAD and i...

    Authors: Jinman Zhuang, Zhongwu Chen, Zishan Chen, Jin Chen, Maolin Liu, Xinying Xu, Yuhang Liu, Shuyan Yang, Zhijian Hu and Fei He
    Citation: Respiratory Research 2022 23:123
  6. Strenuous endurance exercise in sub-zero temperatures can cause airway damage that may lead to EIB. Prolonged exercise can also elicit greater immune perturbations than short-duration exercise. However, the in...

    Authors: Angelos Gavrielatos, Iluta Ratkevica, Nikolai Stenfors and Helen G. Hanstock
    Citation: Respiratory Research 2022 23:121
  7. Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic inflammation and airway remodeling. Human epididymis protein 4 (HE4) plays a critical role in various inflammatory...

    Authors: Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng and Jungang Xie
    Citation: Respiratory Research 2022 23:120
  8. Asthma is significantly related to chronic rhinosinusitis (CRS) both in prevalence and severity. However, the clinical patterns of uncontrolled asthma with and without comorbid CRS are still unclear. This stud...

    Authors: Kai Huang, Fangyuan Li, Xuechen Wang, Bing Yan, Ming Wang, Shuling Li, Wenling Yu, Xiaofang Liu, Chengshuo Wang, Jianmin Jin and Luo Zhang
    Citation: Respiratory Research 2022 23:119
  9. Currently the only available therapies for fibrotic Interstitial Lung Disease are administered systemically, often causing significant side effects. Inhaled therapy could avoid these but to date there is no ev...

    Authors: Theresia A. Mikolasch, Eunice Oballa, Mitra Vahdati-Bolouri, Emily Jarvis, Yi Cui, Anthony Cahn, Rebecca L. Terry, Jagdeep Sahota, Ricky Thakrar, Peter Marshall and Joanna C. Porter
    Citation: Respiratory Research 2022 23:118
  10. To evaluate the safety and efficacy of bilateral balloon pulmonary angioplasty (BPA) as compared with unilateral BPA for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH).

    Authors: Cheng Hong, Jianmin Lu, Xiaofeng Wu, Wenliang Guo, Jielong Lin, Riken Chen, Haimin Liu, Haiming Chen, Yongxia Lei, Jian Wang, Yue Zhong, Chunying Zhuang and Xinlu Wang
    Citation: Respiratory Research 2022 23:117
  11. Asthma is a complex condition largely attributed to the interactions among genes and environments as a heterogeneous phenotype. Obesity is significantly associated with asthma development, and genetic studies ...

    Authors: Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Xiao Chang, Frank D. Mentch, Kenny Nguyen, Lifeng Tian, Joseph Glessner, Patrick M. A. Sleiman and Hakon Hakonarson
    Citation: Respiratory Research 2022 23:116
  12. Published studies suggest physical recovery from the COVID-19 is complex, with many individuals experiencing persistent symptoms. There is a paucity of data investigating the longer-term trajectory of physical...

    Authors: Kate O’Brien, Liam Townsend, Joanne Dowds, Ciarán Bannan, Parthiban Nadarajan, Brian Kent, Niamh Murphy, Gráinne Sheill, Ignacio Martin-Loeches and Emer Guinan
    Citation: Respiratory Research 2022 23:115
  13. Non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) infections are frequently associated with exacerbations of chronic obstructive pulmonary disease (COPD). Results were reported with a tw...

    Authors: Ilaria Galgani, Margherita Annaratone, Daniela Casula, Gennaro Di Maro, Michel Janssens, Annaelisa Tasciotti, Tino Schwarz, Murdo Ferguson and Ashwani Kumar Arora
    Citation: Respiratory Research 2022 23:114
  14. With prevalent global air pollution, individuals with certain genetic predispositions and sensitivities are at of higher risk of developing respiratory symptoms including chronic cough. Studies to date have re...

    Authors: Michael Yoon, Min Hyung Ryu, Ryan D. Huff, Maria G. Belvisi, Jaclyn Smith and Chris Carlsten
    Citation: Respiratory Research 2022 23:113
  15. HPS-1 is a genetic type of Hermansky-Pudlak syndrome (HPS) with highly penetrant pulmonary fibrosis (HPSPF), a restrictive lung disease that is similar to idiopathic pulmonary fibrosis (IPF). Hps1ep/ep (pale ear)...

    Authors: Shachar Abudi-Sinreich, Steven P. Bodine, Tadafumi Yokoyama, Nathanial J. Tolman, Michal Tyrlik, Lauren C. Testa, Chen G. Han, Heidi M. Dorward, Stephen M. Wincovitch, Yair Anikster, William A. Gahl, Resat Cinar, Bernadette R. Gochuico and May Christine V. Malicdan
    Citation: Respiratory Research 2022 23:112
  16. While the prevalence and disease burden of bronchiectasis are increasing, data in the world’s largest population are lacking. We aimed to investigate the prevalence and disease burden of bronchiectasis in Chin...

    Authors: Jingnan Feng, Lina Sun, Xiaoyan Sun, Lu Xu, Lili Liu, Guozhen Liu, Jinxi Wang, Pei Gao, Siyan Zhan, Yahong Chen, Shengfeng Wang and Yongchang Sun
    Citation: Respiratory Research 2022 23:111
  17. Retinoid-related orphan receptor-α (RORα) and autophagy dysregulation are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD), but little is known regarding their association. We in...

    Authors: Hak-Su Kim, Chang Hyeok An, Danielle Teller, Su-Jin Moon, Gi Won Hwang and Jin Woo Song
    Citation: Respiratory Research 2022 23:110
  18. Chronic obstructive pulmonary disease (COPD) guidelines recommend reserving triple therapy of inhaled corticosteroid (ICS), long-acting β2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) for patients ...

    Authors: Claus F. Vogelmeier, Heinrich Worth, Roland Buhl, Carl-Peter Criée, Eva Gückel and Peter Kardos
    Citation: Respiratory Research 2022 23:109
  19.  The main long-term complication after lung transplantation is bronchiolitis obliterans syndrome (BOS), a deadly condition in which neutrophils may play a critical pathophysiological role. Recent studies show ...

    Authors: Jesper M. Magnusson, Petrea Ericson, Sara Tengvall, Marit Stockfelt, Bettina Brundin, Anders Lindén and Gerdt C. Riise
    Citation: Respiratory Research 2022 23:108
  20. Pulmonary arteriovenous malformations (PAVMs) are rare but cause various manifestations. Although the diameter of feeding arteries has been linked to treatment decisions, relationships among the characteristic...

    Authors: Xu Ma, Ling-Ling Li, Dong Yu, Bing Jie and Sen Jiang
    Citation: Respiratory Research 2022 23:107
  21. Chronic obstructive pulmonary disease (COPD) receives low awareness and is undertreated in China. Understanding the burden and treatment of COPD across the nation is important for improving quality of care for...

    Authors: Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Yahong Chen, Wenhua Jian, Hongyan Shang and Chen Wang
    Citation: Respiratory Research 2022 23:106
  22. Quantitative computed tomography (QCT) analysis may serve as a tool for assessing the severity of coronavirus disease 2019 (COVID-19) and for monitoring its progress. The present study aimed to assess the as...

    Authors: Ying Su, Ze-song Qiu, Jun Chen, Min-jie Ju, Guo-guang Ma, Jin-wei He, Shen-ji Yu, Kai Liu, Fleming Y. M. Lure, Guo-wei Tu, Yu-yao Zhang and Zhe Luo
    Citation: Respiratory Research 2022 23:105
  23. Ionizing radiation (IR) can induce pulmonary fibrosis by causing epithelial mesenchymal transition (EMT), but the exact mechanism has not been elucidated. To investigate the molecular mechanism of how radiatio...

    Authors: Ziyan Yan, Xingkun Ao, Xinxin Liang, Zhongmin Chen, Yuhao Liu, Ping Wang, Duo Wang, Zheng Liu, Xiaochang Liu, Jiaojiao Zhu, Shenghui Zhou, Pingkun Zhou and Yongqing Gu
    Citation: Respiratory Research 2022 23:104
  24. The Internet is commonly used by patients to acquire health information. To date, no studies have evaluated the quality of information available on YouTube regarding lymphangioleiomyomatosis (LAM). Our aim was...

    Authors: Finn M. Wilkens, Claudia Ganter, Katharina Kriegsmann, Heinrike Wilkens, Nicolas Kahn, Gillian C. Goobie, Christopher J. Ryerson and Michael Kreuter
    Citation: Respiratory Research 2022 23:103
  25. The use of vital signs monitoring in the early recognition of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) post-hospital discharge is limited. This study investigated whether continu...

    Authors: Grace Hawthorne, Matthew Richardson, Neil J. Greening, Dale Esliger, Samuel Briggs-Price, Emma J. Chaplin, Lisa Clinch, Michael C. Steiner, Sally J. Singh and Mark W. Orme
    Citation: Respiratory Research 2022 23:102
  26. Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refrac...

    Authors: Sonal Mistry, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E. Scott, Marc Chikhani, John G. Laffey, Jonathan G. Hardman, Luigi Camporota and Declan G. Bates
    Citation: Respiratory Research 2022 23:101
  27. Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal lung disease. In addition to dense fibrous tissue, abnormal angiogenesis is also an important feature of IPF. Pigment epithelium-derived ...

    Authors: Xichun Qin, Caili Jia, Jingtian Liang, Jiali Chen, Xiucheng Liu, Zhixiang Chao, Hao Qin, Yanliang Yuan, Zhiwei Liu, Zhongming Zhang, Hongyan Dong and Hao Zhang
    Citation: Respiratory Research 2022 23:100
  28. Chronic cough is prevalent in the clinic. The existing therapies are mostly limited to medical treatment, with poor curative effects and serious side effects. Studies have suggested that the right dorsolateral...

    Authors: Peijun Gui, Lin Wang, Liya Guo, Chunwei Wu, Bo Zhang, Chen Chen and Ying Xie
    Citation: Respiratory Research 2022 23:99
  29. Spirometry quality assurance is a challenging task across levels of healthcare tiers, especially in primary care. Deep learning may serve as a support tool for enhancing spirometry quality. We aimed to develop...

    Authors: Yimin Wang, Yicong Li, Wenya Chen, Changzheng Zhang, Lijuan Liang, Ruibo Huang, Jianling Liang, Dandan Tu, Yi Gao, Jinping Zheng and Nanshan Zhong
    Citation: Respiratory Research 2022 23:98
  30. Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These featu...

    Authors: Auyon J. Ghosh, Brian D. Hobbs, Jeong H. Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P. Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise…
    Citation: Respiratory Research 2022 23:97
  31. Clinically differentiating preinvasive lesions (atypical adenomatous hyperplasia, AAH and adenocarcinoma in situ, AIS) from invasive lesions (minimally invasive adenocarcinomas, MIA and invasive adenocarcinoma...

    Authors: Minghui Zhu, Zhen Yang, Miaoyu Wang, Wei Zhao, Qiang Zhu, Wenjia Shi, Hang Yu, Zhixin Liang and Liangan Chen
    Citation: Respiratory Research 2022 23:96
  32. The distribution of allergens has geographic characteristics. Local epidemiological data provides evidence-based strategies for the prevention and management of allergic diseases. Age and sex differences may e...

    Authors: Xiaolan Ying, Xinyi Qi, Yong Yin, Hongmei Wang, Hao Zhang, Haohua Jiang, Lin Yang and Jinhong Wu
    Citation: Respiratory Research 2022 23:95
  33. Before the pandemic of coronavirus disease (COVID-19), rapidly improving acute respiratory distress syndrome (ARDS), mostly defined by early extubation, had been recognized as an increasingly prevalent subphen...

    Authors: Evdokia Gavrielatou, Katerina Vaporidi, Vasiliki Tsolaki, Nikos Tserlikakis, George E. Zakynthinos, Eleni Papoutsi, Aikaterini Maragkuti, Athina G. Mantelou, Dimitrios Karayiannis, Zafeiria Mastora, Dimitris Georgopoulos, Epaminondas Zakynthinos, Christina Routsi, Spyros G. Zakynthinos, Edward J. Schenck, Anastasia Kotanidou…
    Citation: Respiratory Research 2022 23:94
  34. Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer globally, with average age of cancer patients becoming younger gradually. It is of significance to gain a comprehensive understandin...

    Authors: Pei Zhang, Li Li, Bing Wang, Xu Ran, Shengrong Yang, Yujie Luo, Yunhe Li, Zhenghong Wang, Yi Liu and Bing Zhu
    Citation: Respiratory Research 2022 23:93
  35. Mechanical ventilation is often employed to facilitate breathing in patients suffering from respiratory illnesses and disabilities. Despite the benefits, there are risks associated with ventilator-induced lung...

    Authors: C. A. Mariano, S. Sattari, K. A. M. Quiros, T. M. Nelson and M. Eskandari
    Citation: Respiratory Research 2022 23:92
  36. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high morbidity and limited treatment options. Type 2 diabetes mellitus (T2DM) is a common comorbid illness among patients with IPF...

    Authors: Taylor T. Teague, Stephanie R. Payne, Bryan T. Kelly, Timothy M. Dempsey, Rozalina G. McCoy, Lindsey R. Sangaralingham and Andrew H. Limper
    Citation: Respiratory Research 2022 23:91
  37. Global distributions and trends of the risk-attributable burdens of chronic obstructive pulmonary disease (COPD) have rarely been systematically explored. To guide the formulation of targeted and accurate stra...

    Authors: Jiahua Zou, Tao Sun, Xiaohui Song, Ye-Mao Liu, Fang Lei, Ming-Ming Chen, Ze Chen, Peng Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Yunman Luo, Ping Wang and Hongliang Li
    Citation: Respiratory Research 2022 23:90
  38. Patients suffering from combined obstructive and interstitial lung disease (O-ILD) represent a pathological entity which still has to be well clinically described. The aim of this descriptive and explorative s...

    Authors: Julien Guiot, Monique Henket, Anne-Noëlle Frix, Fanny Gester, Marie Thys, Laurie Giltay, Colin Desir, Catherine Moermans, Makon-Sébastien Njock, Paul Meunier, Jean-Louis Corhay and Renaud Louis
    Citation: Respiratory Research 2022 23:89
  39. Most phenotyping paradigms in sarcoidosis are based on expert opinion; however, no paradigm has been widely adopted because of the subjectivity in classification. We hypothesized that cluster analysis could be...

    Authors: Nancy W. Lin, Jaron Arbet, Margaret M. Mroz, Shu-Yi Liao, Clara I. Restrepo, Annyce S. Mayer, Li Li, Briana Q. Barkes, Sarah Schrock, Nabeel Hamzeh, Tasha E. Fingerlin, Nichole E. Carlson and Lisa A. Maier
    Citation: Respiratory Research 2022 23:88
  40. Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than ...

    Authors: Jane Chanda Kabwe, Hirofumi Sawada, Yoshihide Mitani, Hironori Oshita, Naoki Tsuboya, Erquan Zhang, Junko Maruyama, Yoshiki Miyasaka, Hideyoshi Ko, Kazunobu Oya, Hiromasa Ito, Noriko Yodoya, Shoichiro Otsuki, Hiroyuki Ohashi, Ryuji Okamoto, Kaoru Dohi…
    Citation: Respiratory Research 2022 23:87
  41. Endoplasmic reticulum (ER) stress is involved in the pathological process of pulmonary fibrosis, including IPF. It affects a broad scope of cellular types during pulmonary fibrosis but the role in epithelial-m...

    Authors: Xiaoyu Yang, Wei Sun, Xiaoyan Jing, Qian Zhang, Hui Huang and Zuojun Xu
    Citation: Respiratory Research 2022 23:86
  42. In the INBUILD trial in patients with progressive fibrosing interstitial lung diseases (ILDs), nintedanib reduced the rate of decline in forced vital capacity compared with placebo, with side-effects that were...

    Authors: Vincent Cottin, Fernando J. Martinez, R. Gisli Jenkins, John A. Belperio, Hideya Kitamura, Maria Molina-Molina, Inga Tschoepe, Carl Coeck, Dirk Lievens and Ulrich Costabel
    Citation: Respiratory Research 2022 23:85
  43. Insomnia is highly prevalent among patients with allergic disease and asthma; however, few studies have investigated their causal relationship. We aim to explore the causal association between insomnia and all...

    Authors: Rong Li, Yiting Chen, Anda Zhao, Lili Huang, Zichong Long, Wenhui Kang, Yong Yin, Shilu Tong, Yongmei Guo and Shenghui Li
    Citation: Respiratory Research 2022 23:84
  44. The 6-min walking distance (6MWD) test is a useful tool to obtain a measure of functional exercise capacity. However, reference equations have been mainly based on selected populations or small samples. The pu...

    Authors: Lucia Cazzoletti, Maria Elisabetta Zanolin, Gianluigi Dorelli, Pietro Ferrari, Luca Giuseppe Dalle Carbonare, Ernesto Crisafulli, Mulubirhan Assefa Alemayohu, Mario Olivieri, Giuseppe Verlato and Marcello Ferrari
    Citation: Respiratory Research 2022 23:83
  45. A small number of studies suggested that air pollution was associated with idiopathic pulmonary fibrosis (IPF) exacerbation, incidence and mortality. However, no studies to date were conducted in regions where...

    Authors: Lirong Liang, Yutong Cai, Baolei Lyu, Di Zhang, Shuilian Chu, Hang Jing, Kazem Rahimi and Zhaohui Tong
    Citation: Respiratory Research 2022 23:81
  46. In elderly populations, paracetamol may be used regularly for conditions such as osteoarthritis. Paracetamol has been associated with respiratory disease through a proposed mechanism of glutathione depletion a...

    Authors: Thu-Lan Kelly, Michael Ward, Nicole L. Pratt, Emmae Ramsay, Marianne Gillam and Elizabeth E. Roughead
    Citation: Respiratory Research 2022 23:80
  47. Respiratory modalities applied at the end of life may affect the burden of distressing symptoms and quality of dying and death (QODD) among patients with end-stage interstitial lung disease (ILD); however, the...

    Authors: Takafumi Koyauchi, Yuzo Suzuki, Kazuki Sato, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Koshi Yokomura, Shiro Imokawa, Hidenori Nakamura, Tatsuya Morita and Takafumi Suda
    Citation: Respiratory Research 2022 23:79
  48. Dry powder (DP) synthetic lung surfactant may be an effective means of noninvasive delivery of surfactant therapy to premature infants supported with nasal continuous positive airway pressure (nCPAP) in low-re...

    Authors: Frans J. Walther, Alan J. Waring, Monicah Otieno and Robert M. DiBlasi
    Citation: Respiratory Research 2022 23:78

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