Skip to main content

Articles

Page 1 of 65

  1. Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course.

    Authors: Theodoros Karampitsakos, Sebastiano Torrisi, Katerina Antoniou, Effrosyni Manali, Ioanna Korbila, Ourania Papaioannou, Fotios Sampsonas, Matthaios Katsaras, Eirini Vasarmidi, Despoina Papakosta, Kalliopi Domvri, Eva Fouka, Ioannis Organtzis, Zoe Daniil, Ilias Dimeas, Paraskevi Kirgou…

    Citation: Respiratory Research 2021 22:140

    Content type: Research

    Published on:

  2. Data describing the effects of weight change across adulthood on asthma are important for the prevention of asthma. This study aimed to investigate the association between weight change from early to middle ad...

    Authors: Tao Wang, Yunping Zhou, Nan Kong, Jianzhong Zhang, Guo Cheng and Yuxin Zheng

    Citation: Respiratory Research 2021 22:139

    Content type: Research

    Published on:

  3. Whole-body vibration training (WBV) performed on a vibration platform can significantly improve physical performance in patients with chronic obstructive pulmonary disease. It has been suggested that an import...

    Authors: Rainer Gloeckl, Tessa Schneeberger, Daniela Leitl, Tobias Reinold, Christoph Nell, Inga Jarosch, Klaus Kenn and Andreas R. Koczulla

    Citation: Respiratory Research 2021 22:138

    Content type: Research

    Published on:

  4. Recent studies have provided evidence for an important contribution of the immune system in the pathophysiology of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH...

    Authors: T. Koudstaal, D. van Uden, J. A. C. van Hulst, P. Heukels, I. M. Bergen, L. W. Geenen, V. J. M. Baggen, A. E. van den Bosch, L. M. van den Toorn, P. P. Chandoesing, M. Kool, E. Boersma, R. W. Hendriks and K. A. Boomars

    Citation: Respiratory Research 2021 22:137

    Content type: Research

    Published on:

  5. In France, data regarding epidemiology and management of severe asthma are scarce. The objective of this study was to describe asthma phenotypes using a cluster analysis in severe asthmatics recruited in a rea...

    Authors: Chantal Raherison-Semjen, Eric Parrat, Cécilia Nocent-Eijnani, Gilles Mangiapan, Anne Prudhomme, Jean-Philippe Oster, Corinne Aperre de Vecchi, Cyril Maurer, Didier Debieuvre and Laurent Portel

    Citation: Respiratory Research 2021 22:136

    Content type: Research

    Published on:

  6. Real-world data regarding outcomes of idiopathic pulmonary fibrosis (IPF) are scarce, outside of registries. In France, pirfenidone and nintedanib are only reimbursed for documented IPF, with similar reimburse...

    Authors: Manon Belhassen, Faustine Dalon, Maëva Nolin and Eric Van Ganse

    Citation: Respiratory Research 2021 22:135

    Content type: Research

    Published on:

  7. Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. Alveolar epithelial cells (AECs) primarily sense alveolar hy...

    Authors: Yanxia Wang, Xiaoming Li, Wen Niu, Jian Chen, Bo Zhang, Xiumin Zhang, Yingmei Wang, Shaokang Dang and Zhichao Li

    Citation: Respiratory Research 2021 22:134

    Content type: Research

    Published on:

  8. Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of th...

    Authors: Claire Healy, Natalia Munoz-Wolf, Janné Strydom, Lynne Faherty, Niamh C. Williams, Sarah Kenny, Seamas C. Donnelly and Suzanne M. Cloonan

    Citation: Respiratory Research 2021 22:133

    Content type: Review

    Published on:

  9. Pseudomonas aeruginosa is one of the commonest bacteria colonizing the airway in patients with non-cystic fibrosis bronchiectasis. Pseudomonas aeruginosa colonization is associated with poor outcomes in patients ...

    Authors: Wang Chun Kwok, James Chung Man Ho, Terence Chi Chun Tam, Mary Sau Man Ip and David Chi Leung Lam

    Citation: Respiratory Research 2021 22:132

    Content type: Research

    Published on:

  10. Limited data are available on practical predictors of successful de-cannulation among the patients who undergo tracheostomies. We evaluated factors associated with failed de-cannulations to develop a predictio...

    Authors: Chul Park, Ryoung-Eun Ko, Jinhee Jung, Soo Jin Na and Kyeongman Jeon

    Citation: Respiratory Research 2021 22:131

    Content type: Research

    Published on:

  11. Fibrinogen is the first qualified prognostic/predictive biomarker for exacerbations in patients with chronic obstructive pulmonary disease (COPD). The IMPACT trial investigated fluticasone furoate/umeclidinium...

    Authors: Dave Singh, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, Peter Lange, Sally Lettis, David A. Lipson, David Mannino, Neil Martin, Fernando J. Martinez, Bruce E. Miller, Robert Wise, Chang-Qing Zhu and David Lomas

    Citation: Respiratory Research 2021 22:130

    Content type: Research

    Published on:

  12. Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cel...

    Authors: Peta Bradbury, Cassandra P. Nader, Aylin Cidem, Sandra Rutting, Dianne Sylvester, Patrick He, Maria C. Rezcallah, Geraldine M. O’Neill and Alaina J. Ammit

    Citation: Respiratory Research 2021 22:129

    Content type: Research

    Published on:

  13. Positive associations between ambient PM2.5 and cardiorespiratory disease have been well demonstrated during the past decade. However, few studies have examined the adverse effects of PM2.5 based on an entire pop...

    Authors: Zhan Ren, Xingyuan Liu, Tianyu Liu, Dieyi Chen, Kuizhuang Jiao, Xiaodie Wang, Jingdong Suo, Haomin Yang, Jingling Liao and Lu Ma

    Citation: Respiratory Research 2021 22:128

    Content type: Research

    Published on:

  14. Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study ha...

    Authors: Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell Jr, Alejandro P. Comellas…

    Citation: Respiratory Research 2021 22:127

    Content type: Research

    Published on:

  15. There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the rele...

    Authors: William Z. Zhang, Katherine L. Hoffman, Kristen T. Schiffer, Clara Oromendia, Michelle C. Rice, Igor Barjaktarevic, Stephen P. Peters, Nirupama Putcha, Russell P. Bowler, J. Michael Wells, David J. Couper, Wassim W. Labaki, Jeffrey L. Curtis, Meilan K. Han, Robert Paine III, Prescott G. Woodruff…

    Citation: Respiratory Research 2021 22:126

    Content type: Research

    Published on:

  16. Idiopathic pulmonary fibrosis (IPF) predominantly affects individuals aged > 60 years who have several comorbidities. Nintedanib is an approved treatment for IPF, which reduces the rate of decline in forced vi...

    Authors: Ian Glaspole, Francesco Bonella, Elena Bargagli, Marilyn K. Glassberg, Fabian Caro, Wibke Stansen, Manuel Quaresma, Leticia Orsatti and Elisabeth Bendstrup

    Citation: Respiratory Research 2021 22:125

    Content type: Research

    Published on:

  17. Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is essential to inform prognosis and treatment. In 2018, the ATS/ERS/JRS/ALAT and Fleischner Society released new diagnostic guidelines for usual inter...

    Authors: Angela R. Shih, Chayanin Nitiwarangkul, Brent P. Little, Benjamin W. Roop, Sreyankar Nandy, Margit V. Szabari, Nathaniel Mercaldo, Sarah Mercaldo, Sydney B. Montesi, Ashok Muniappan, Sarita R. Berigei, David A. Lynch, Amita Sharma and Lida P. Hariri

    Citation: Respiratory Research 2021 22:124

    Content type: Research

    Published on:

  18. Long-term non-invasive ventilation (NIV) is as an established treatment option for chronic hypercapnic COPD patients. Beneficial effects have also been shown during exercise, but this is restricted to rehabili...

    Authors: Daniel Sebastian Majorski, Friederike Sophie Magnet, Saadia Thilemann, Claudia Schmoor, Wolfram Windisch and Sarah Bettina Schwarz

    Citation: Respiratory Research 2021 22:123

    Content type: Research

    Published on:

  19. Asthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may be responsible for asthma immunopathology. However, existing models to...

    Authors: Ailu Chen, Maria P. Diaz-Soto, Miguel F. Sanmamed, Taylor Adams, Jonas C. Schupp, Amolika Gupta, Clemente Britto, Maor Sauler, Xiting Yan, Qing Liu, Gustavo Nino, Charles S. Dela Cruz, Geoffrey L. Chupp and Jose L. Gomez

    Citation: Respiratory Research 2021 22:122

    Content type: Research

    Published on:

  20. Pulmonary hypertension (PH) is a complex pulmonary vascular disease characterized by an imbalance in vasoconstrictor/vasodilator signaling within the pulmonary vasculature. Recent evidence suggests that exposu...

    Authors: Shanshan Xu, Xuefeng Xu, Ziming Zhang, Lingling Yan, Liyan Zhang and Lizhong Du

    Citation: Respiratory Research 2021 22:121

    Content type: Research

    Published on:

  21. The differential diagnosis fibrotic hypersensitivity pneumonitis (HP) versus idiopathic pulmonary fibrosis (IPF) is important but challenging. Recent diagnostic guidelines for HP emphasize including multidisci...

    Authors: Sabina A. Guler, Eva Wohlfarth, Sabina Berezowska, Thomas K. Geiser, Lukas Ebner and Manuela Funke-Chambour

    Citation: Respiratory Research 2021 22:120

    Content type: Research

    Published on:

  22. In the absence of PCR detection of SARS-CoV-2 RNA, accurate diagnosis of COVID-19 is challenging. Low-dose computed tomography (CT) detects pulmonary infiltrates with high sensitivity, but findings may be non-...

    Authors: Jochen Schneider, Hrvoje Mijočević, Kurt Ulm, Bernhard Ulm, Simon Weidlich, Silvia Würstle, Kathrin Rothe, Matthias Treiber, Roman Iakoubov, Ulrich Mayr, Tobias Lahmer, Sebastian Rasch, Alexander Herner, Egon Burian, Fabian Lohöfer, Rickmer Braren…

    Citation: Respiratory Research 2021 22:119

    Content type: Research

    Published on:

  23. Lung transplant (LTx) recipients are at increased risk for airway infections, but the cause of infection is often difficult to establish with traditional culture-based techniques. The objectives of the study w...

    Authors: Lisa I. Påhlman, Lokeshwaran Manoharan and Anna Stjärne Aspelund

    Citation: Respiratory Research 2021 22:118

    Content type: Research

    Published on:

  24. Epidemiology of dysphagia and its drivers in obstructive sleep apnea (OSA) are poorly understood. The study aims to investigate the prevalence of dysphagia symptoms and their association with demographic and c...

    Authors: Nicole Pizzorni, Dejan Radovanovic, Marica Pecis, Rosaria Lorusso, Federica Annoni, Alice Bartorelli, Maurizio Rizzi, Antonio Schindler and Pierachille Santus

    Citation: Respiratory Research 2021 22:117

    Content type: Research

    Published on:

  25. Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide. Currently, the selection of recipients in Japan is mainly based on the registration order. Hence, scientific ev...

    Authors: Masaki Ikeda, Toru Oga, Toyofumi F. Chen-Yoshikawa, Junko Tokuno, Takahiro Oto, Tomoyo Okawa, Yoshinori Okada, Miki Akiba, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Maki Isomi, Kazuo Chin…

    Citation: Respiratory Research 2021 22:116

    Content type: Research

    Published on:

  26. Idiopathic non-specific interstitial pneumonia (iNSIP), idiopathic pleuroparenchymal fibroelastosis (iPPFE), and unclassifiable idiopathic interstitial pneumonia (IIP) are IIPs with chronic fibrotic phenotypes...

    Authors: Akira Yamagata, Machiko Arita, Hiromasa Tachibana, Fumiaki Tokioka, Chikatoshi Sugimoto, Hiromitsu Sumikawa, Tomonori Tanaka, Hideki Yasui, Tomoyuki Fujisawa, Yutaro Nakamura, Takafumi Suda and Tadashi Ishida

    Citation: Respiratory Research 2021 22:115

    Content type: Research

    Published on:

  27. Obstructive sleep apnea (OSA) might lead to oxidative stress, inflammation and elevated circulating copeptin, proANP and proADM levels. We aimed to evaluate whether the levels of these prohormones are higher i...

    Authors: Meropi Karakioulaki, Peter Grendelmeier, Werner Strobel, Thomas Schmid, Kathleen Jahn, Leticia Grize, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2021 22:114

    Content type: Research

    Published on:

  28. Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, ...

    Authors: R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes and L. E. Donnelly

    Citation: Respiratory Research 2021 22:113

    Content type: Research

    Published on:

  29. Influenza is a highly contagious, acute, febrile respiratory infection caused by a negative-sense, single-stranded RNA virus, which belongs in the Orthomyxoviridae family. Cigarette smoke (CS) exposure worsens...

    Authors: Wenxin Wu, Lili Tian, Wei Zhang, J. Leland Booth, Erola Ainsua-Enrich, Susan Kovats, Brent R. Brown and Jordan P. Metcalf

    Citation: Respiratory Research 2021 22:112

    Content type: Research

    Published on:

  30. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly subjects, and epidemiol...

    Authors: Fabrizio Luppi, Meena Kalluri, Paola Faverio, Michael Kreuter and Giovanni Ferrara

    Citation: Respiratory Research 2021 22:109

    Content type: Review

    Published on:

  31. Overuse of short-acting beta-2 agonists (SABA), which do not treat the underlying inflammation of asthma, is linked to poor clinical outcomes such as increased exacerbation risk. This study, as part of the SAB...

    Authors: Heinrich Worth, Carl-Peter Criée, Claus F. Vogelmeier, Peter Kardos, Eva-Maria Becker, Karel Kostev, Ingo Mokros and Andrea Schneider

    Citation: Respiratory Research 2021 22:108

    Content type: Research

    Published on:

  32. Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a la...

    Authors: Björn C. Frye, Karoline I. Gaede, Cesare Saltini, Milton D. Rossman, Dimitri S. Monos, Ken D. Rosenman, Christine R. Schuler, Ainsley Weston, Ralf Wegner, Rainer Noth, Gernot Zissel, Stefan Schreiber, Michael Nothnagel and Joachim Müller-Quernheim

    Citation: Respiratory Research 2021 22:107

    Content type: Letter to the Editor

    Published on:

  33. Cystic fibrosis is a debilitating, autosomal recessive disease which results in chronic upper and lower airway infection and inflammation. In this study, four adult patients presenting with cystic fibrosis and...

    Authors: Brett Wagner Mackenzie, Camila Dassi, Anitha Vivekanandan, Melissa Zoing, Richard G. Douglas and Kristi Biswas

    Citation: Respiratory Research 2021 22:106

    Content type: Research

    Published on:

  34. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understo...

    Authors: Shabarinath Nambiar, Britt Clynick, Bong S. How, Adam King, E. Haydn Walters, Nicole S. Goh, Tamera J. Corte, Robert Trengove, Dino Tan and Yuben Moodley

    Citation: Respiratory Research 2021 22:105

    Content type: Research

    Published on:

  35. Workplaces with elevated organic dust levels such as animal feed barns also commonly have elevated levels of gasses, such as CO2. Workers exposed to such complex environments often experience respiratory effects ...

    Authors: David Schneberger, Upkardeep Pandher, Brooke Thompson and Shelley Kirychuk

    Citation: Respiratory Research 2021 22:104

    Content type: Research

    Published on:

  36. Oral corticosteroids are important components of pharmacotherapy in severe asthma. Our objective was to describe the extent, trends, and factors associated with exposure to oral corticosteroids (OCS) in a seve...

    Authors: Mohsen Sadatsafavi, Amir Khakban, Hamid Tavakoli, Solmaz Ehteshami-Afshar, Larry D. Lynd and J. Mark FitzGerald

    Citation: Respiratory Research 2021 22:103

    Content type: Research

    Published on:

  37. We would like to comment on the recently published article titled: “Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients” by Ricci et al. The authors grouped the patients in...

    Authors: Prateek Lohia, Shweta Kapur, Pragnesh Patel and Berhane Seyoum

    Citation: Respiratory Research 2021 22:102

    Content type: Letter to the Editor

    Published on:

  38. Late onset non-infectious pulmonary complications (LONIPCs) following allogenic hematopoietic stem cell transplantation (allo-HSCT) confer a significant mortality risk. Lung transplantation (LTx) has the poten...

    Authors: Peter Riddell, Ram Vasudevan-Nampoothiri, Jin Ma, Lianne G. Singer, Jeff H. Lipton and Stephen C. Juvet

    Citation: Respiratory Research 2021 22:101

    Content type: Research

    Published on:

  39. Whole lung tissue transcriptomic profiling studies in chronic obstructive pulmonary disease (COPD) have led to the identification of several genes associated with the severity of airflow limitation and/or the ...

    Authors: Xiuying Li, Guillaume Noell, Tracy Tabib, Alyssa D. Gregory, Humberto E. Trejo Bittar, Ravi Vats, Tomasz W. Kaminski, John Sembrat, Mark E. Snyder, Divay Chandra, Kong Chen, Chunbin Zou, Yingze Zhang, Prithu Sundd, John F. McDyer, Frank Sciurba…

    Citation: Respiratory Research 2021 22:100

    Content type: Research

    Published on:

  40. COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia and fibrosis. The molecular hypoxia response pathway has been ...

    Authors: Atish Gheware, Dhwani Dholakia, Sadasivam Kannan, Lipsa Panda, Ritu Rani, Bijay Ranjan Pattnaik, Vaibhav Jain, Yash Parekh, M. Ghalib Enayathullah, Kiran Kumar Bokara, Venkatesan Subramanian, Mitali Mukerji, Anurag Agrawal and Bhavana Prasher

    Citation: Respiratory Research 2021 22:99

    Content type: Research

    Published on:

  41. A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome. However, there are no data on the effect of MUC...

    Authors: Davide Biondini, Elisabetta Cocconcelli, Nicol Bernardinello, Giulia Lorenzoni, Chiara Rigobello, Sara Lococo, Gioele Castelli, Simonetta Baraldo, Manuel G. Cosio, Dario Gregori, Marina Saetta, Elisabetta Balestro and Paolo Spagnolo

    Citation: Respiratory Research 2021 22:98

    Content type: Research

    Published on:

  42. Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrot...

    Authors: Shyam Nathan, Haijun Zhang, Mirko Andreoli, Philip L. Leopold and Ronald G. Crystal

    Citation: Respiratory Research 2021 22:97

    Content type: Research

    Published on:

  43. No clinical studies to date have compared the inspiratory and expiratory airway lumen area between supine and standing positions. Thus, the aims of this study were twofold: (1) to compare inspiratory and expir...

    Authors: Shotaro Chubachi, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Wakako Yamasawa, Hidehiro Irie, Mitsuru Murata, Koichi Fukunaga and Masahiro Jinzaki

    Citation: Respiratory Research 2021 22:95

    Content type: Research

    Published on:

  44. Pneumonia is the most frequently encountered postoperative pulmonary complications (PPC) after orthotopic liver transplantation (OLT), which cause high morbidity and mortality rates. We aimed to develop a mode...

    Authors: Chaojin Chen, Dong Yang, Shilong Gao, Yihan Zhang, Liubing Chen, Bohan Wang, Zihan Mo, Yang Yang, Ziqing Hei and Shaoli Zhou

    Citation: Respiratory Research 2021 22:94

    Content type: Research

    Published on:

  45. Cut offs for fat-free mass index (FFMI) and appendicular skeletal muscle mass index (ASMI) are available for diagnosing low muscle mass in patients with COPD. This study aimed to investigate: (1) the frequency...

    Authors: Felipe V. C. Machado, Martijn A. Spruit, Miriam T. J. Groenen, Sarah Houben-Wilke, Paula P. van Melick, Nidia A. Hernandes, Annemie M. W. J. Schols, Fabio Pitta, Emiel F. M. Wouters and Frits M. E. Franssen

    Citation: Respiratory Research 2021 22:93

    Content type: Research

    Published on:

  46. People with rare lung diseases often suffer the burden of delayed diagnosis, limited treatment options, and difficulties in finding expert physicians. One of the reasons for the delay in diagnosis is the limit...

    Authors: Tiago M. Alfaro, Marlies S. Wijsenbeek, Pippa Powell, Daiana Stolz, John R. Hurst, Michael Kreuter and Catharina C. Moor

    Citation: Respiratory Research 2021 22:92

    Content type: Review

    Published on:

Annual Journal Metrics

\