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  1. The effect of dual systemic antibiotic therapy against Pseudomonas aeruginosa in patients with pre-existing lung disease is unknown. To assess whether dual systemic antibiotics against P. aeruginosa in outpatient...

    Authors: Josefin Eklöf, Imane Achir Alispahic, Karin Armbruster, Therese Sophie Lapperre, Andrea Browatzki, Rikke Holmen Overgaard, Zitta Barrella Harboe, Julie Janner, Mia Moberg, Charlotte Suppli Ulrik, Helle Frost Andreassen, Ulla Møller Weinreich, Jakob Lyngby Kjærgaard, Jenny Villadsen, Camilla Sund Fenlev, Torben Tranborg Jensen…
    Citation: Respiratory Research 2024 25:236
  2. Abnormal remodeling of distal pulmonary arteries in patients with pulmonary arterial hypertension (PAH) leads to progressively increased pulmonary vascular resistance, followed by right ventricular hypertrophy...

    Authors: Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William C. Nichols, Paul M. Hassoun, Allen D. Everett and Roger A. Johns
    Citation: Respiratory Research 2024 25:235
  3. The concurrent circulation of SARS-CoV-2 with other respiratory viruses is unstoppable and represents a new diagnostic reality for clinicians and clinical microbiology laboratories. Multiplexed molecular testi...

    Authors: Manca Luštrek, Zala Cesar, Alen Suljič, Rok Kogoj, Nataša Knap, Monika Jevšnik Virant, Tina Uršič, Miroslav Petrovec, Tatjana Avšič-Županc and Miša Korva
    Citation: Respiratory Research 2024 25:234
  4. There is inconclusive evidence to suggest that the expression of programmed cell death ligand 1 (PD-L1) is a putative predictor of response to EGFR-TKI therapy in advanced EGFR-mutant non-small cell lung cance...

    Authors: Yaohua Hu, Yidan Zhang, You Lu, Yingqi Xu, Jianlin Xu, Hua Zhong, Lei Cheng and Runbo Zhong
    Citation: Respiratory Research 2024 25:233
  5. Acute respiratory distress syndrome or ARDS is an acute, severe form of respiratory failure characterised by poor oxygenation and bilateral pulmonary infiltrates. Advancements in signal processing and machine ...

    Authors: Tu K. Tran, Minh C. Tran, Arun Joseph, Phi A. Phan, Vicente Grau and Andrew D. Farmery
    Citation: Respiratory Research 2024 25:232
  6. Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense m...

    Authors: Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao and Reynold A. Panettieri Jr.
    Citation: Respiratory Research 2024 25:231
  7. Airway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of extracellular matrix (ECM), such as collagen deposition and structural disturban...

    Authors: Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu and Liang Dong
    Citation: Respiratory Research 2024 25:230
  8. COPD is associated with the development of lung cancer. A protective effect of inhaled corticosteroids (ICS) on lung cancer is still controversial. Hence, this study investigated the development of lung cancer...

    Authors: Ji Eun Park, Eunyoung Lee, Dave Singh, Eun Kyung Kim, Bumhee Park and Joo Hun Park
    Citation: Respiratory Research 2024 25:229
  9. Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This explo...

    Authors: Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic…
    Citation: Respiratory Research 2024 25:228
  10. Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the airways. The glucocorticoid receptor (GR) mediates the intracellular sig...

    Authors: Liang Zhou, Michael Roth, Eleni Papakonstantinou, Michael Tamm and Daiana Stolz
    Citation: Respiratory Research 2024 25:227
  11. This study aimed to explore the incidence of occult lymph node metastasis (OLM) in clinical T1 − 2N0M0 (cT1 − 2N0M0) small cell lung cancer (SCLC) patients and develop machine learning prediction models using pre...

    Authors: Xu Jiang, Chao Luo, Xin Peng, Jing Zhang, Lin Yang, Li-Zhi Liu, Yan-Fen Cui, Meng-Wen Liu, Lei Miao, Jiu-Ming Jiang, Jia-Liang Ren, Xiao-Tang Yang, Meng Li and Li Zhang
    Citation: Respiratory Research 2024 25:226
  12. The soft palate and back of the throat represent vulnerable early infection sites for SARS-CoV-2, influenza, streptococci, and many other pathogens. We demonstrate that snoring causes aerosolization of pharyng...

    Authors: Tayeb Kakeshpour, Kevin P. Fennelly and Adriaan Bax
    Citation: Respiratory Research 2024 25:224
  13. Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by a variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory co...

    Authors: Jing Yang, Jinman Li, Linfeng Zhang, Zijie Shen, Yan Xiao, Guoliang Zhang, Mingwei Chen, Fuhui Chen, Ling Liu, Ying Wang, Lan Chen, Xinming Wang, Li Zhang, Lu Wang, Zhang Wang, Jianwei Wang…
    Citation: Respiratory Research 2024 25:223
  14. To investigate the association of serum anti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS).

    Authors: Hongxia Yang, Qingning Chen, Chao Sun, Qiwen Jin, Lining Zhang, Qingyan Liu, Qinglin Peng, Guochun Wang and Xin Lu
    Citation: Respiratory Research 2024 25:222
  15. Pulmonary hypertension (PH) is regarded as cardiovascular disease with an extremely poor prognosis, primarily due to irreversible vascular remodeling. Despite decades of research progress, the absence of defin...

    Authors: Huixue Ba, Yingfan Guo, Yujie Jiang, Ying Li, Xuejing Dai, Yuan Liu and Xiaohui Li
    Citation: Respiratory Research 2024 25:221
  16. Pulmonary arterial hypertension (PAH) is a complex and progressive illness that has a multifaceted origin, significant fatality rates, and profound effects on health. The pathogenesis of PAH is poorly defined ...

    Authors: Qi Yang, Banghui Lai, Hao Xie, Mingbin Deng, Jun Li, Yan Yang, Juyi Wan, Bin Liao and Feng Liu
    Citation: Respiratory Research 2024 25:220
  17. Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking.

    Authors: Alvaro Moreira, Michelle Noronha, Jooby Joy, Noah Bierwirth, Aina Tarriela, Aliha Naqvi, Sarah Zoretic, Maxwell Jones, Ali Marotta, Taylor Valadie, Jonathan Brick, Caitlyn Winter, Melissa Porter, Isabelle Decker, Matteo Bruschettini and Sunil K. Ahuja
    Citation: Respiratory Research 2024 25:219
  18. Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic interstitial lung disease characterized by progressive dyspnea and decreased lung function, yet its exact etiology remains unclear. It is of great sign...

    Authors: Zetao Liu, Zhiyu Peng, Huahang Lin, Ke Zhou, Linchuan Liang, Jie Cao, Zhaokang Huang and Jiandong Mei
    Citation: Respiratory Research 2024 25:217
  19. The growing concern of pediatric mortality demands heightened preparedness in clinical settings, especially within intensive care units (ICUs). As respiratory-related admissions account for a substantial porti...

    Authors: Johayra Prithula, Muhammad E. H. Chowdhury, Muhammad Salman Khan, Khalid Al-Ansari, Susu M. Zughaier, Khandaker Reajul Islam and Abdulrahman Alqahtani
    Citation: Respiratory Research 2024 25:216
  20. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, the efficacy of EGFR-TKIs in wild-type EGFR tumor...

    Authors: Han Wang, Xiaohui Du, Wenwen Liu, Congcong Zhang, Ying Li, Jingwen Hou, Yi Yu, Guiru Li and Qi Wang
    Citation: Respiratory Research 2024 25:215
  21. Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there is an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) and glycolipid m...

    Authors: Chenyang Li, Yu Peng, Xiaoyue Zhu, Yupu Liu, Jianyin Zou, Huaming Zhu, Xinyi Li, Hongliang Yi, Jian Guan, Xu Zhang, Huajun Xu and Shankai Yin
    Citation: Respiratory Research 2024 25:214
  22. Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions. Statins and proprotein co...

    Authors: Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee and Jung-Won Park
    Citation: Respiratory Research 2024 25:213
  23. Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whe...

    Authors: Youjia Yu, Chunyan Chu, Kang Wang, Yan Li, Zhengsheng Mao, Li Hu, Jie Wang, Yanfang Yu, Hao Sun and Feng Chen
    Citation: Respiratory Research 2024 25:212
  24. Bronchiectasis is a condition characterized by abnormal and irreversible bronchial dilation resulting from lung tissue damage and can be categorized into two main groups: cystic fibrosis (CF) and non-CF bronch...

    Authors: Heryk Motta, Júlia Catarina Vieira Reuwsaat, Fernanda Cortez Lopes, Graciele Viezzer, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Paulo de Tarso Roth Dalcin, Charley Christian Staats, Marilene Henning Vainstein and Lívia Kmetzsch
    Citation: Respiratory Research 2024 25:211
  25. Mitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in the pathogenesis of group 3 pulmonary hypertension (PH). And G protei...

    Authors: Ting Hu, Chaohui Mu, Yanmiao Li, Wanming Hao, Xinjuan Yu, Yixuan Wang, Wei Han and Qinghai Li
    Citation: Respiratory Research 2024 25:210
  26. Limited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients with post-acute sequelae of COVID-19 (PASC) especially dyspnea and fat...

    Authors: Po-Chun Lo, Jia-Yih Feng, Yi-Han Hsiao, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hsin-Kuo Ko and Diahn-Warng Perng
    Citation: Respiratory Research 2024 25:209
  27. We estimated the prevalence and mortality risks of preserved ratio impaired spirometry (PRISm) and chronic obstructive pulmonary disease (COPD) in the US adult population.

    Authors: Christopher J. Cadham, Hayoung Oh, MeiLan K. Han, David Mannino, Steven Cook, Rafael Meza, David T. Levy and Luz María Sánchez-Romero
    Citation: Respiratory Research 2024 25:208
  28. The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD an...

    Authors: N. Frantzi, X. P. Nguyen, C. Herr, P. Alter, S. Söhler, D. Soriano, H. Watz, B. Waschki, F. Trinkmann, M. Eichenlaub, F. C. Trudzinski, J. D. Michels-Zetsche, A. Omlor, F. Seiler, I. Moneke, F. Biertz…
    Citation: Respiratory Research 2024 25:207
  29. Previous studies have largely neglected the role of sulfur metabolism in LUAD, and no study has combine iron, copper, and sulfur-metabolism associated genes together to create prognostic signatures.

    Authors: Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu and Fancai Lai
    Citation: Respiratory Research 2024 25:206
  30. Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role...

    Authors: Li Zhu, Zhuhua Wu, Yingli Liu, Yue Ming, Pei Xie, Miao Jiang and Yong Qi
    Citation: Respiratory Research 2024 25:205
  31. The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear.

    Authors: Vincent Laiman, Hsiao-Chi Chuang, Yu-Chun Lo, Tzu-Hsuen Yuan, You-Yin Chen, Didik Setyo Heriyanto, Fara Silvia Yuliani, Kian Fan Chung and Jer-Hwa Chang
    Citation: Respiratory Research 2024 25:204
  32. Although electronic nose (eNose) has been intensively investigated for diagnosing lung cancer, cross-site validation remains a major obstacle to be overcome and no studies have yet been performed.

    Authors: Meng-Rui Lee, Mu-Hsiang Kao, Ya-Chu Hsieh, Min Sun, Kea-Tiong Tang, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih and Chong-Jen Yu
    Citation: Respiratory Research 2024 25:203
  33. Extracellular mitochondrial DNA (mtDNA) is released from damaged cells and increases in the serum and bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. While increased levels...

    Authors: Jun Fukihara, Koji Sakamoto, Yoshiki Ikeyama, Taiki Furukawa, Ryo Teramachi, Kensuke Kataoka, Yasuhiro Kondoh, Naozumi Hashimoto and Makoto Ishii
    Citation: Respiratory Research 2024 25:202
  34. Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and t...

    Authors: Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li and Mei Meng
    Citation: Respiratory Research 2024 25:201
  35. Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) remains a devastating clinical complication seriously affecting the therapeutic outcome of preterm infants. Hence, early prevention and tim...

    Authors: Dan Wang, Shuwei Huang, Jingke Cao, Zhichun Feng, Qiannan Jiang, Wanxian Zhang, Jia Chen, Shelby Kutty, Changgen Liu, Wenyu Liao, Le Zhang, Guli Zhu, Wenhao Guo, Jie Yang, Lin Liu, Jingwei Yang…
    Citation: Respiratory Research 2024 25:199
  36. The association between tuberculous fibrosis and lung cancer development has been reported by some epidemiological and experimental studies; however, its underlying mechanisms remain unclear, and the role of m...

    Authors: Seong Ji Woo, Youngmi Kim, Hyun-Jung Kang, Harry Jung, Dong Hyuk Youn, Yoonki Hong, Jae Jun Lee and Ji Young Hong
    Citation: Respiratory Research 2024 25:198
  37. OSA is a known medical condition that is associated with several comorbidities and affect patients’ quality of life. The association between OSA and lung cancer remains debated. Some studies reported increased...

    Authors: Mohamed H. Zidan, Hany M. Shaarawy, Heba S. Gharraf, Suzan F. Helal, Maged Hassan and Rana Rizk
    Citation: Respiratory Research 2024 25:197
  38. The treatment response to corticosteroids in patients with sarcoidosis is highly variable. CD4+ T cells are central in sarcoid pathogenesis and their phenotype in peripheral blood (PB) associates with disease cou...

    Authors: Jelle R. Miedema, Lieke J. de Jong, Vivienne Kahlmann, Ingrid M. Bergen, Caroline E. Broos, Marlies S. Wijsenbeek, Rudi W. Hendriks and Odilia B. J. Corneth
    Citation: Respiratory Research 2024 25:196
  39. Lipocalin-2 (LCN2) is a secretory glycoprotein upregulated by oxidative stress; moreover, patients with idiopathic pulmonary fibrosis (IPF) have shown increased LCN2 levels in bronchoalveolar lavage fluid (BAL...

    Authors: Hiroki Tanahashi, Hiroshi Iwamoto, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori
    Citation: Respiratory Research 2024 25:195
  40. Asthma is a common chronic disease amongst children. Epidemiological studies showed that the mortality rate of asthma in children is still high worldwide. Asthma control is therefore essential to minimize asth...

    Authors: Phillip L.W. Au-Doung, Jason C.H. Chan, Oliver Y.H. Kui, Marco K.Y. Ho, Yin Ting Cheung, Jenny K.W. Lam, Hak-Kim Chan, John Brannan, Kate C.C. Chan, Albert M. Li and Sharon S.Y. Leung
    Citation: Respiratory Research 2024 25:194
  41. Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) ...

    Authors: Niccolette Schaunaman, Diana Cervantes, Taylor Nichols, Mari Numata, Julie G. Ledford, Monica Kraft and Hong Wei Chu
    Citation: Respiratory Research 2024 25:193
  42. Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU)....

    Authors: David Drummond, Charlotte Roy, Matthieu Cornet, Julie Bucher, Véronique Boussaud, Françoise Le Pimpec-Barthes, Margaux Pontailler, Olivier Raisky, Vanessa Lopez, Claudio Barbanti, Romain Guillemain, Sylvain Renolleau, Marion Grimaud, Mehdi Oualha, Laure de Saint Blanquat and Isabelle Sermet-Gaudelus
    Citation: Respiratory Research 2024 25:190
  43. Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by t...

    Authors: Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O’Kane, Brian Button, Lorcan P. McGarvey and Fionnuala T. Lundy
    Citation: Respiratory Research 2024 25:188

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