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  1. The physiological response and the potentially beneficial effects of positive end-expiratory pressure (PEEP) for lung protection and optimization of ventilation during spontaneous breathing in patients with ac...

    Authors: Hannes Widing, Elena Chiodaroli, Francesco Liggieri, Paola Sara Mariotti, Katarina Hallén and Gaetano Perchiazzi
    Citation: Respiratory Research 2022 23:324
  2. Influenza viruses cause seasonal epidemics worldwide with a significant morbimortality burden. Clinical spectrum of Influenza is wide, being respiratory failure (RF) one of its most severe complications. This ...

    Authors: Blanca Ayuso, Antonio Lalueza, Estibaliz Arrieta, Eva María Romay, Álvaro Marchán-López, María José García-País, Dolores Folgueira, María José Gude, Cecilia Cueto, Antonio Serrano and Carlos Lumbreras
    Citation: Respiratory Research 2022 23:323
  3. Our previous study showed that circular RNA-gamma-secretase-activating protein (circGSAP) was down-regulated in pulmonary microvascular endothelial cells (PMECs) in response to hypoxia, and regulated the cell ...

    Authors: Yuanyuan Sun, Rong Jiang, Xiaoyi Hu, Sugang Gong, Lan Wang, Wenhui Wu, Jinling Li, Xinyang Kang, Shijin Xia, Jinming Liu, Qinhua Zhao and Ping Yuan
    Citation: Respiratory Research 2022 23:322
  4. The role of the sputum microbiome in chronic obstructive pulmonary disease (COPD) progression remains elusive. As the advent of the new culture-independent microbial sequencing technique makes it possible to d...

    Authors: Wei Li, Bingbing Wang, Min Tan, Xiaolian Song, Shuanshuan Xie and Changhui Wang
    Citation: Respiratory Research 2022 23:321
  5. COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are avai...

    Authors: Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche and Lise Piquilloud
    Citation: Respiratory Research 2022 23:320
  6. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease that is characterised by persistent respiratory symptoms and airflow limitation. The present study reported the burden of COP...

    Authors: Hamidreza Feizi, Mahasti Alizadeh, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Javad Ahmadian Heris, Ali-Asghar Kolahi, Gary S. Collins and Saeid Safiri
    Citation: Respiratory Research 2022 23:319
  7. In the last decade, research on acute respiratory distress syndrome (ARDS) has made considerable progress. However, ARDS remains a leading cause of mortality in the intensive care unit. ARDS presents distinct ...

    Authors: Denise Battaglini, Lou’i Al-Husinat, Ana Gabriela Normando, Adriana Paes Leme, Kleber Franchini, Marcelo Morales, Paolo Pelosi and Patricia RM Rocco
    Citation: Respiratory Research 2022 23:318
  8. Emerging experimental and epidemiological evidence highlights a crucial cross-talk between the intestinal flora and the lungs, termed the “gut-lung axis”. However, the function of the gut microbiota in bronchi...

    Authors: Wen-Wen Wang, Bei Mao, Yang Liu, Shu-Yi Gu, Hai-Wen Lu, Jiu-Wu Bai, Shuo Liang, Jia-Wei Yang, Jian-Xiong Li, Xiao Su, Hai-Yang Hu, Chen Wang and Jin-Fu Xu
    Citation: Respiratory Research 2022 23:317
  9. Eosinophilic asthma is a common subtype of severe asthma with high morbidity and mortality. The cytokine IL-5 has been shown to be a key driver of the development and progression of disease. Although approved ...

    Authors: Linlin Ma, Min Zhu, Guanghui Li, Junwei Gai, Yanfei Li, Huaiyu Gu, Peng Qiao, Xiaofei Li, Weiwei Ji, Rui Zhao, Yue Wu and Yakun Wan
    Citation: Respiratory Research 2022 23:316
  10. Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been com...

    Authors: Kensuke Nakagawara, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Atsuho Morita, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Takanori Asakura, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii…
    Citation: Respiratory Research 2022 23:315
  11. Pregnant women with pulmonary hypertension (PH) have higher mortality rates and poor foetal/neonatal outcomes. Tools to assess these risk factors are not well established.

    Authors: Yuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu…
    Citation: Respiratory Research 2022 23:314
  12. Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we ...

    Authors: Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá and Julio Cortijo
    Citation: Respiratory Research 2022 23:313
  13. The COMPERA 2.0 4-stratum (4-S) risk score has been demonstrated superior over the 3-stratum (3-S) one in patients with pulmonary arterial hypertension and medically managed patients with chronic thromboemboli...

    Authors: Yi Zhang, Xin Li, Qi Jin, Qin Luo, Qing Zhao, Tao Yang, Qixian Zeng, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao and Zhihong Liu
    Citation: Respiratory Research 2022 23:312
  14. Chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging and is associated with comorbid conditions including osteoporosis and sarcopenia. These extrapulmonary conditions are highly preva...

    Authors: Ava C. Wilson, Jessica M. Bon, Stephanie Mason, Alejandro A. Diaz, Sharon M. Lutz, Raul San Jose Estepar, Gregory L. Kinney, John E. Hokanson, Stephen I. Rennard, Richard Casaburi, Surya P. Bhatt, Marguerite R. Irvin, Craig P. Hersh, Mark T. Dransfield, George R. Washko, Elizabeth A. Regan…
    Citation: Respiratory Research 2022 23:311
  15. Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black car...

    Authors: Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas…
    Citation: Respiratory Research 2022 23:310
  16. Preserved Ratio Impaired Spirometry (PRISm) is defined as FEV1/FVC ≥ 70% and FEV1 < 80%pred by pulmonary function test (PFT). It has highly prevalence and is associated with increased respiratory symptoms, sys...

    Authors: Jinjuan Lu, Haiyan Ge, Lin Qi, Shaojie Zhang, Yuling Yang, Xuemei Huang and Ming Li
    Citation: Respiratory Research 2022 23:309
  17. Idiopathic pulmonary fibrosis, the archetype of pulmonary fibrosis (PF), is a chronic lung disease of a poor prognosis, characterized by progressively worsening of lung function. Although histology is still th...

    Authors: Elena Vincenzi, Alice Fantazzini, Curzio Basso, Annalisa Barla, Francesca Odone, Ludovica Leo, Laura Mecozzi, Martina Mambrini, Erica Ferrini, Nicola Sverzellati and Franco Fabio Stellari
    Citation: Respiratory Research 2022 23:308
  18. Patients with interstitial lung disease (ILD) require regular physician visits and referral to specialist ILD clinics. Difficulties or delays in accessing care can limit opportunities to monitor disease trajec...

    Authors: Toby M. Maher, Courtney Schiffman, Michael Kreuter, Catharina C. Moor, Steven D. Nathan, Judit Axmann, Paula Belloni, Monica Bengus, Frank Gilberg, Klaus-Uwe Kirchgaessler and Marlies S. Wijsenbeek
    Citation: Respiratory Research 2022 23:307
  19. The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects and is a potential early biomarker of lung damage. The CC16 single nucleotide polymorphism (SNP) rs3741240 risk allele (A) has ...

    Authors: KC Gribben, AB Wyss, JA Poole, PA Farazi, C Wichman, M Richards-Barber, LE Beane Freeman, PK Henneberger, DM Umbach, SJ London, TD LeVan and Kelli C. Gribben
    Citation: Respiratory Research 2022 23:305
  20. Authors: Hideyasu Yamada, Isao Matsumoto, Naoyuki Makita, Yoshifumi Arita, Nobuya Hayashi, Kurena Mitsuoka, Naoki Tashiro and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:304

    The original article was published in Respiratory Research 2022 23:255

  21. Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognost...

    Authors: Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai and Jorge D. Erusalimsky
    Citation: Respiratory Research 2022 23:303
  22. Currently, programmed death ligand-1 (PD-L1) expression has been widely applied in clinical trials and real-world clinical practice as a major biomarker for the efficacy of immune-checkpoint inhibitors. The pu...

    Authors: Fangqiu Fu, Chaoqiang Deng, Wenrui Sun, Qiang Zheng, Yan Jin, Yuan Li, Yang Zhang and Haiquan Chen
    Citation: Respiratory Research 2022 23:302
  23. Acute respiratory distress syndrome (ARDS) is an acute and critical disease among children and adults, and previous studies have shown that the administration of corticosteroids remains controversial. Therefor...

    Authors: Xinyan Chang, Shaojun Li, Yueqiang Fu, Hongxing Dang and Chengjun Liu
    Citation: Respiratory Research 2022 23:301
  24. Vaccines against SARS-CoV-2 protect from critical or severe pathogenesis also against new variants of concern (VOCs) such as BA.4 and BA.5, but immediate interventions to avoid viral transmission and subsequen...

    Authors: Zaderer Viktoria, Dichtl Stefanie, Bellmann-Weiler Rosa, Lass-Flörl Cornelia, Posch Wilfried and Wilflingseder Doris
    Citation: Respiratory Research 2022 23:300
  25. The effect of ambient temperature on respiratory mortality has been consistently observed throughout the world under different climate change scenarios. Countries experiencing greater inter–annual variability ...

    Authors: Shafkat Jahan, John Paul Cauchi, Charles Galdies, Kathleen England and Darren Wraith
    Citation: Respiratory Research 2022 23:299
  26. Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV1) in the setting of preserved ratio. Little is known about the role of PRISm and its complex relation with smal...

    Authors: Ningning Zhao, Fan Wu, Jieqi Peng, Youlan Zheng, Heshen Tian, Huajing Yang, Zhishan Deng, Zihui Wang, Haiqing Li, Xiang Wen, Shan Xiao, Peiyu Huang, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Shengtang Chen…
    Citation: Respiratory Research 2022 23:298
  27. Routine follow-up of patients hospitalised with COVID-19 is recommended, however due to the ongoing high number of infections this is not without significant health resource and economic burden. In a previous ...

    Authors: Tim JM Wallis, Benjamin Welham, Alex Kong, Tommaso Morelli, Adnan Azim, Jose Horno, Miranda Wilkinson, Hannah Burke, Anna Freeman, Thomas MA Wilkinson, Mark G Jones and Benjamin G Marshall
    Citation: Respiratory Research 2022 23:297
  28. Anticoagulant treatment is recommended for at least three months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related acute pulmonary embolism (PE), but the persistent pulmonary clot burd...

    Authors: Thomas M. Berghaus, Stefanie Bader, Christian Faul, Sabine Haberl, Florian Schwarz, Alessandro Liebich, Alexander Dierks, Malte Kircher, Constantin Lapa and Christian H. Pfob
    Citation: Respiratory Research 2022 23:296
  29. Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrosing lung disease with a predilection for the upper lobe and its progression causes hypoventilation, resulting in hypercapnia. Even though the association...

    Authors: Yuki Yabuuchi, Takefumi Saito, Hitomi Hirano, Mizu Nonaka, Naoki Arai, Kentaro Hyodo, Jun Kanazawa, Yukiko Miura, Shingo Usui, Katsumi Tamura, Tomotaka Kasamatsu, Shuji Oh-ishi, Kenji Hayashihara, Masashi Matsuyama and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:295
  30. Acute exacerbation (AE) is a major cause of death in patients with idiopathic pulmonary fibrosis (IPF). AE-IPF patients require optimal palliative care; however, the real-world clinical situations are poorly u...

    Authors: Norimichi Akiyama, Tomoyuki Fujisawa, Tatsuya Morita, Takafumi Koyauchi, Yoshinobu Matsuda, Masanori Mori, Mitsunori Miyashita, Ryo Tachikawa, Keisuke Tomii, Hiromi Tomioka, Satoshi Hagimoto, Yasuhiro Kondoh, Yoshikazu Inoue and Takafumi Suda
    Citation: Respiratory Research 2022 23:294
  31. Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (...

    Authors: Longyu Shan, Liang Zhang, Xiaolei Zhu, Zhilin Wang, Shaohan Fang, Junfeng Lin, Jianweng Wang, Ning Li, Hongming Liu, Xiaowen Zhang, Yihui Feng, Jingwei Liu, Jianyun Pan, Guanzhi Ye, Xiuyi Yu, Amanda Tufman…
    Citation: Respiratory Research 2022 23:293
  32. Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder, mainly characterized by the development of renal cysts, as well as various extrarenal manifestations. Previous studies have...

    Authors: Runming Wang, Wenya Li, Haiting Dai, Mingli Zhu, Lingyu Li, Guohui Si, Yilina Bai, Hanyu Wu, Xiaoxiang Hu and Yiming Xing
    Citation: Respiratory Research 2022 23:292
  33. Although corticosteroid therapy with dose tapering is the most commonly used treatment for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), there is no consensus on the tapering regimen. This stud...

    Authors: Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa and Yosuke Yamamoto
    Citation: Respiratory Research 2022 23:291
  34. Plexiform lesions, which have a dynamic appearance in structure and cellular composition, are the histological hallmark of severe pulmonary arterial hypertension in humans. The pathogenesis of the lesion devel...

    Authors: Feng-Jin Shao, Xiao-Ling Guo, Jia-Xue Xu, Rui Liu, Dan-Yue Li, Qing-Hao Li, Ting Zhou, Cun Fang and Xun Tan
    Citation: Respiratory Research 2022 23:290
  35. Asthma is one of the most common chronic diseases that affects more than 300 million people worldwide. Though most asthma can be well controlled, individuals with severe asthma experience recurrent exacerbatio...

    Authors: Mengling Xia, Fei Xu, Hangqi Ni, Qing Wang, Ruhui Zhang, Yafang Lou and Jianying Zhou
    Citation: Respiratory Research 2022 23:289
  36. Although cardiovascular comorbidities negatively impact survival in patients with bronchiectasis, there is limited evidence to recommend exercise in this population. We aimed to evaluate whether exercise habit...

    Authors: Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon and Hyun Lee
    Citation: Respiratory Research 2022 23:288
  37. Two opposing B cell subsets have been defined based on their cytokine profile: IL-6 producing effector B cells (B-effs) versus IL-10 producing regulatory B cells (B-regs) that respectively positively or negati...

    Authors: Merel Jacobs, Sven Verschraegen, Bihiyga Salhi, Jasper Anckaert, Pieter Mestdagh, Guy G. Brusselle and Ken R. Bracke
    Citation: Respiratory Research 2022 23:287
  38. The role of micro RNAs (miRNAs) in asthma remains unclear. In this study, we examined the role of miRNA in targeting FOXO1 in asthma. Results showed that miR-493-5p was one of the differentially expressed miRN...

    Authors: Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu and Zhengrong Chen
    Citation: Respiratory Research 2022 23:286
  39. Ventilatory power is a novel index which could reflect both ventilation efficiency and peripheral blood flow. However, its clinical value in pulmonary hypertension (PH) is rarely discussed. In the present stud...

    Authors: Xin Li, Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Qin Luo and Zhihong Liu
    Citation: Respiratory Research 2022 23:285
  40. The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of...

    Authors: Sébastien Puigrenier, Jonathan Giovannelli, Nicolas Lamblin, Pascal De Groote, Marie Fertin, Jean-François Bervar, Antoine Lamer, Jean-Louis Edmé, Marie-Hélène Balquet, Vincent Sobanski, David Launay, Éric Hachulla and Sébastien Sanges
    Citation: Respiratory Research 2022 23:284
  41. Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive...

    Authors: Ferenc Peták, Gergely H. Fodor, Álmos Schranc, Roberta Südy, Ádám L. Balogh, Barna Babik, André Dos Santos Rocha, Sam Bayat, Davide Bizzotto, Raffaele L. Dellacà and Walid Habre
    Citation: Respiratory Research 2022 23:283
  42. Loss of muscle mass and function are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Acute exacerbations, in turn, significantly contribute to upgrade these systemic co...

    Authors: Carme Casadevall, Antonio Sancho-Muñoz, Ignacio Vicente, Sergi Pascual-Guardia, Mireia Admetlló and Joaquim Gea
    Citation: Respiratory Research 2022 23:282
  43. Genes involved in lung development may become dysregulated in adult life and contribute to the pathogenesis of lung diseases. Multiple genes regulate lung development, including Forkhead box protein P1-4 (FoxP...

    Authors: Alexis Andreas, Abby Maloy, Toru Nyunoya, Yingze Zhang and Divay Chandra
    Citation: Respiratory Research 2022 23:281
  44. Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subj...

    Authors: Hélène Salvator, Aristine Cheng, Lindsey B. Rosen, Peter R. Williamson, John E. Bennett, Anuj. Kashyap, Li Ding, Kyung J. Kwon-Chung, Ho Namkoong, Christa S. Zerbe and Steven M. Holland
    Citation: Respiratory Research 2022 23:280
  45. Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs a...

    Authors: Fang Yi, Chen Zhan, Baojuan Liu, Hu Li, Jianmeng Zhou, Jiaman Tang, Wen Peng, Wei Luo, Qiaoli Chen and Kefang Lai
    Citation: Respiratory Research 2022 23:279
  46. SARS-CoV-2 pre-existing T-cell immune reactivity can be present in some people. A general perturbation of the main peripheral lymphocyte subsets has been described in severe COVID-19 patients, but very few stu...

    Authors: Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Tahmina Mirashirova, Timur Muratov and Dimitri Poddighe
    Citation: Respiratory Research 2022 23:278
  47. Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with poor treatment options. However, most mouse models of COPD produce a primarily emphysematous disease not recapitulating clinicall...

    Authors: Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju and Steven M. Rowe
    Citation: Respiratory Research 2022 23:277
  48. Monitoring vaccine effectiveness (VE) remains a priority for epidemiological research throughout the COVID-19 pandemic. VE against infection declines with the emergence of new SARS-CoV-2 variants of concern (V...

    Authors: Anton Barchuk, Anna Bulina, Mikhail Cherkashin, Natalia Berezina, Tatyana Rakova, Darya Kuplevatskaya, Dmitriy Skougarevskiy and Artemiy Okhotin
    Citation: Respiratory Research 2022 23:276
  49. Hypersensitivity pneumonitis (HP) is an interstitial lung disease characterized by antigen-triggered neutrophilic exacerbations. Although CD4+ T cells are sufficient for HP pathogenesis, this never translated int...

    Authors: Olivier Courtemanche, Carole-Ann Huppé, Pascale Blais Lecours, Ophélie Lerdu, Joanny Roy, Jean-François Lauzon-Joset, Marie-Renée Blanchet, Mathieu C. Morissette and David Marsolais
    Citation: Respiratory Research 2022 23:275

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