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  1. Research

    IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

    Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors N...

    Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma and Hong Ye

    Respiratory Research 2017 18:174

    Published on: 20 September 2017

  2. Research

    Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

    Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR...

    Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara and Yasuhiko Nishioka

    Respiratory Research 2017 18:172

    Published on: 15 September 2017

  3. Research

    Cardiovascular risk in patients with alpha-1-antitrypsin deficiency

    Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients w...

    Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier and Robert Bals

    Respiratory Research 2017 18:171

    Published on: 15 September 2017

  4. Research

    Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

    Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at dete...

    Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal and Manal S. Fawzy

    Respiratory Research 2017 18:169

    Published on: 8 September 2017

  5. Review

    Intersectin-1s deficiency in pulmonary pathogenesis

    Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have demonstrated that deficiency of ITSN-1s is a cruci...

    Niranjan Jeganathan, Dan Predescu and Sanda Predescu

    Respiratory Research 2017 18:168

    Published on: 6 September 2017

  6. Review

    WNT signaling – lung cancer is no exception

    Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the va...

    Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei and Judit E. Pongracz

    Respiratory Research 2017 18:167

    Published on: 5 September 2017

  7. Research

    Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome

    Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical i...

    Xin Lv, Tao Wen, Jiong Song, Dong Xie, Liang Wu, Xuemei Jiang, Ping Jiang and Zongmei Wen

    Respiratory Research 2017 18:165

    Published on: 2 September 2017

  8. Research

    RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

    Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS)...

    Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou and Jordan P. Metcalf

    Respiratory Research 2017 18:166

    Published on: 2 September 2017

  9. Research

    Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients

    Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...

    Solveig Tangedal, Marianne Aanerud, Rune Grønseth, Christine Drengenes, Harald G. Wiker, Per S. Bakke and Tomas M. Eagan

    Respiratory Research 2017 18:164

    Published on: 29 August 2017

  10. Research

    Expiratory central airway collapse in stable COPD and during exacerbations

    Tracheal obstruction resulting from expiratory tracheal deformation has been associated with respiratory symptoms and severe airway exacerbations. In chronic obstructive pulmonary disease (COPD), acute exacerb...

    Paul Leong, Anne Tran, Jhanavi Rangaswamy, Laurence E. Ruane, Michael W. Fernando, Martin I. MacDonald, Kenneth K. Lau and Philip G. Bardin

    Respiratory Research 2017 18:163

    Published on: 25 August 2017

  11. Research

    Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

    COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors.

    Andreas Horner, Joan B. Soriano, Milo A. Puhan, Michael Studnicka, Bernhard Kaiser, Lowie E. G. W. Vanfleteren, Louisa Gnatiuc, Peter Burney, Marc Miravitlles, Francisco García-Rio, Julio Ancochea, Ana M. Menezes, Rogelio Perez-Padilla, Maria Montes de Oca, Carlos A. Torres-Duque, Andres Caballero…

    Respiratory Research 2017 18:162

    Published on: 23 August 2017

  12. Research

    Utility of autoimmune serology testing in the assessment of uncharacterized interstitial lung disease: a large retrospective cohort review

    Autoimmune serologies are often obtained in the initial evaluation of uncharacterized interstitial lung disease (ILD). Whether this practice is helpful in delineating connective-tissue disease related ILD (CTD...

    Mohammad Alsumrain, Federica De Giacomi, Shireen Mirza and Teng Moua

    Respiratory Research 2017 18:161

    Published on: 23 August 2017

  13. Research

    Effect of smoking and comorbidities on survival in idiopathic pulmonary fibrosis

    Cigarette smoking has been associated with the risk of idiopathic pulmonary fibrosis (IPF). Certain comorbidities have been associated with reduced survival although some studies have indicated that current sm...

    Miia Kärkkäinen, Hannu-Pekka Kettunen, Hanna Nurmi, Tuomas Selander, Minna Purokivi and Riitta Kaarteenaho

    Respiratory Research 2017 18:160

    Published on: 22 August 2017

  14. Research

    IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

    Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction.

    Emmanuel Briend, G. John Ferguson, Michiko Mori, Gautam Damera, Katherine Stephenson, Natasha A. Karp, Sanjay Sethi, Christine K. Ward, Matthew A. Sleeman, Jonas S. Erjefält and Donna K. Finch

    Respiratory Research 2017 18:159

    Published on: 22 August 2017

  15. Erratum

    Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

    Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Respiratory Research 2017 18:158

    Published on: 21 August 2017

    The original article was published in Respiratory Research 2017 18:8

  16. Research

    24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD

    Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover stu...

    Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose and Ubaldo Martin

    Respiratory Research 2017 18:157

    Published on: 18 August 2017

  17. Review

    Regulation of human airway smooth muscle cell migration and relevance to asthma

    Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the ...

    Brittany Salter, Cara Pray, Katherine Radford, James G. Martin and Parameswaran Nair

    Respiratory Research 2017 18:156

    Published on: 16 August 2017

  18. Review

    Role and regulation of MKP-1 in airway inflammation

    Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over...

    Seyed M. Moosavi, Pavan Prabhala and Alaina J. Ammit

    Respiratory Research 2017 18:154

    Published on: 10 August 2017

  19. Research

    Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

    Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice...

    Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf and Koustav Ganguly

    Respiratory Research 2017 18:152

    Published on: 9 August 2017

  20. Research

    A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease

    Interleukin-1 receptor 1 (IL-1R1) inhibition is a potential strategy for treating patients with chronic obstructive pulmonary disease (COPD). MEDI8968, a fully human monoclonal antibody, binds selectively to I...

    Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold and René van der Merwe

    Respiratory Research 2017 18:153

    Published on: 9 August 2017

  21. Research

    Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation

    Alveolar type 2 (AT2) cells play important roles in maintaining adult lung homeostasis. AT2 cells isolated from the lung have revealed the cell-specific functions of AT2 cells. Comprehensive molecular and tran...

    Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro and Toyohiro Hirai

    Respiratory Research 2017 18:150

    Published on: 7 August 2017

  22. Review

    Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers

    The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after l...

    Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson and Lars C. Huber

    Respiratory Research 2017 18:151

    Published on: 7 August 2017

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