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  1. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement...

    Authors: Toby M. Maher, Juliet K. Simpson, Joanna C. Porter, Frederick J. Wilson, Robert Chan, Rhena Eames, Yi Cui, Sarah Siederer, Simon Parry, Julia Kenny, Robert J. Slack, Jagdeep Sahota, Lyn Paul, Peter Saunders, Philip L. Molyneaux, Pauline T. Lukey…

    Citation: Respiratory Research 2020 21:75

    Content type: Research

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  2. Since December 2019, 2019 novel coronavirus pneumonia emerged in Wuhan city and rapidly spread throughout China and even the world. We sought to analyse the clinical characteristics and laboratory findings of ...

    Authors: Gemin Zhang, Jie Zhang, Bowen Wang, Xionglin Zhu, Qiang Wang and Shiming Qiu

    Citation: Respiratory Research 2020 21:74

    Content type: Research

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  3. Interstitial lung disease (ILD) is a heterogeneous group of mainly chronic lung diseases differing in disease course and prognosis. For most subtypes, evidence on relevance and outcomes of hospitalisations is ...

    Authors: Julia Wälscher, Sabine Witt, Larissa Schwarzkopf and Michael Kreuter

    Citation: Respiratory Research 2020 21:73

    Content type: Research

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  4. Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characteri...

    Authors: Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz and Dave Singh

    Citation: Respiratory Research 2020 21:72

    Content type: Research

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  5. Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, right ventricular hypertrophy and failure. So far no effective treatment exists for this disease; hence...

    Authors: Shanshan Zhang, Xiaoli Liu, Li Li Ge, Kailin Li, Yongchao Sun, Fang Wang, Ying Han, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Chaoyue Xu, Yuan Chen, Ou chen, Zhaohua Zhang and Yun Luan

    Citation: Respiratory Research 2020 21:71

    Content type: Research

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  6. Glycopyrrolate (GP)/formoterol fumarate (FF; GFF) metered dose inhaler is a fixed-dose combination dual bronchodilator for patients with chronic obstructive pulmonary disease (COPD); however, whether the effic...

    Authors: Jinping Zheng, Jin-fu Xu, Martin Jenkins, Pryseley Nkouibert Assam, Lijiao Wang and Brian J. Lipworth

    Citation: Respiratory Research 2020 21:69

    Content type: Research

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  7. Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior thera...

    Authors: Kevin J. Anstrom, Imre Noth, Kevin R. Flaherty, Rex H. Edwards, Joan Albright, Amanda Baucom, Maria Brooks, Allan B. Clark, Emily S. Clausen, Michael T. Durheim, Dong-Yun Kim, Jerry Kirchner, Justin M. Oldham, Laurie D. Snyder, Andrew M. Wilson, Stephen R. Wisniewski…

    Citation: Respiratory Research 2020 21:68

    Content type: Study protocol

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  8. The use of electronic cigarettes (ECIGs) is increasing, but the impact of ECIG-vapor on cellular processes like inflammation or host defense are less understood. The aim of the present study was to compare the...

    Authors: Christian Herr, Konstantinos Tsitouras, Julia Niederstraßer, Christina Backes, Christoph Beisswenger, Li Dong, Loïc Guillot, Andreas Keller and Robert Bals

    Citation: Respiratory Research 2020 21:67

    Content type: Research

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  9. It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury. Melatonin exe...

    Authors: Geng-Chin Wu, Chung-Kan Peng, Wen-I Liao, Hsin-Ping Pao, Kun-Lun Huang and Shi-Jye Chu

    Citation: Respiratory Research 2020 21:65

    Content type: Research

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  10. The long-term effect of average volume-assured pressure support (AVAPS) on health-related quality of life (HRQOL) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory f...

    Authors: Doaa M. Magdy and Ahmed Metwally

    Citation: Respiratory Research 2020 21:64

    Content type: Research

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  11. Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habi...

    Authors: Sergi Pascual-Guardia, Michelle Ataya, Isabel Ramírez-Martínez, José Yélamos, Roberto Chalela, Salomé Bellido, Miguel López-Botet and Joaquim Gea

    Citation: Respiratory Research 2020 21:63

    Content type: Research

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  12. This study was to investigate of the mechanism by which histone deacetylase (HDAC) 8 inhibitor ameliorated airway hyperresponsiveness (AHR) and allergic airway inflammation.

    Authors: Meng-lu Li, Xin-ming Su, Yuan Ren, Xuan Zhao, Ling-fei Kong and Jian Kang

    Citation: Respiratory Research 2020 21:62

    Content type: Research

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  13. Pulmonary malignant neoplasms have a high worldwide morbidity and mortality, so the study of these malignancies using microRNAs (miRNAs) has attracted great interest and enthusiasm. The aim of this study was t...

    Authors: Chang-Yu Liang, Zu-Yun Li, Ting-Qing Gan, Ye-Ying Fang, Bin-Liang Gan, Wen-Jie Chen, Yi-Wu Dang, Ke Shi, Zhen-Bo Feng and Gang Chen

    Citation: Respiratory Research 2020 21:60

    Content type: Research

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  14. Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical r...

    Authors: Thomas Salaets, Margo Aertgeerts, André Gie, Janne Vignero, Derek de Winter, Yannick Regin, Julio Jimenez, Greetje Vande Velde, Karel Allegaert, Jan Deprest and Jaan Toelen

    Citation: Respiratory Research 2020 21:59

    Content type: Research

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  15. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic options. Curdione, a sesquiterpene ...

    Authors: Peng Liu, Kang Miao, Lei Zhang, Yong Mou, Yongjian Xu, Weining Xiong, Jun Yu and Yi Wang

    Citation: Respiratory Research 2020 21:58

    Content type: Research

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  16. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are characterized by uncontrolled activati...

    Authors: Gali Epstein Shochet, Elizabetha Brook, Becky Bardenstein-Wald and David Shitrit

    Citation: Respiratory Research 2020 21:56

    Content type: Research

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  17. Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients.

    Authors: Eleanor L. Axson, Kishan Ragutheeswaran, Varun Sundaram, Chloe I. Bloom, Alex Bottle, Martin R. Cowie and Jennifer K. Quint

    Citation: Respiratory Research 2020 21:54

    Content type: Review

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  18. Persistent pulmonary hypertension of the newborn (PPHN) is characterized by sustained high levels of pulmonary vascular resistance after birth with etiology unclear; Arterial blood oxygen saturation of Tibetan...

    Authors: Mingbang Wang, Deyi Zhuang, Mei Mei, Haiyan Ma, Zixiu Li, Fusheng He, Guoqiang Cheng, Guang Lin and Wenhao Zhou

    Citation: Respiratory Research 2020 21:53

    Content type: Research

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  19. Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT resp...

    Authors: Annika W. M. Goorsenberg, Julia N. S. d’Hooghe, Annelies M. Slats, Joost G. van den Aardweg, Jouke T. Annema and Peter I. Bonta

    Citation: Respiratory Research 2020 21:52

    Content type: Research

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  20. The risk of tuberculosis (TB) in patients with impaired kidney function remains unclear by different stages of renal function impairment.

    Authors: Chin-Chung Shu, Yu-Feng Wei, Yi-Chun Yeh, Hsien-Ho Lin, Chung-Yu Chen, Ping-Huai Wang, Shih-Lung Cheng, Jann-Yuan Wang and Chong-Jen Yu

    Citation: Respiratory Research 2020 21:51

    Content type: Research

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  21. Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clini...

    Authors: Sundeep S. Salvi, Bill B. Brashier, Jyoti Londhe, Kanchan Pyasi, Vandana Vincent, Shilpa S. Kajale, Sajid Tambe, Kuldeep Mandani, Arjun Nair, Sze Mun Mak, Sapna Madas, Sanjay Juvekar, Louise E. Donnelly and Peter J. Barnes

    Citation: Respiratory Research 2020 21:50

    Content type: Research

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  22. Pragmatic use of the anti-fibrotic medications pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF) in the United States (US) has not been studied and may be different from international settings...

    Authors: Colin H. Holtze, Elizabeth A. Freiheit, Susan L. Limb, John L. Stauffer, Karina Raimundo, Wayne T. Pan, Kevin R. Flaherty and Hyun J. Kim

    Citation: Respiratory Research 2020 21:48

    Content type: Research

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  23. Many patients with chronic obstructive pulmonary disease (COPD) still experience daily symptoms, exacerbations, and accelerated lung function decline, even when receiving maximal combined treatment with inhale...

    Authors: Dave Singh, Fernando J. Martinez, Henrik Watz, Thomas Bengtsson and Brian T. Maurer

    Citation: Respiratory Research 2020 21:47

    Content type: Research

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  24. Female smokers have increased risk for chronic obstructive pulmonary disease (COPD) compared with male smokers who have a similar history of cigarette smoke exposure. Tertiary lymphoid follicles are often foun...

    Authors: Anthony Tam, Naoya Tanabe, Andrew Churg, Joanne L. Wright, James C. Hogg and Don D. Sin

    Citation: Respiratory Research 2020 21:46

    Content type: Research

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  25. Ventilator-associated pneumonia (VAP) is a significant cause of mortality in the intensive care unit. Early diagnosis of VAP is important to provide appropriate treatment and reduce mortality. Developing a non...

    Authors: Chung-Yu Chen, Wei-Chi Lin and Hsiao-Yu Yang

    Citation: Respiratory Research 2020 21:45

    Content type: Research

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  26. To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and female...

    Authors: Xiaoyue Ge, Tiantian Zhu, Xinyi Zhang, Ye Liu, Yonglong Wang and Weifang Zhang

    Citation: Respiratory Research 2020 21:44

    Content type: Research

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  27. The pathophysiology of congenital cystic adenomatoid malformations (CCAM) of the lung remains poorly understood.

    Authors: Guillaume Lezmi, Shamila Vibhushan, Claudia Bevilaqua, Nicolas Crapart, Nicolas Cagnard, Naziha Khen-Dunlop, Christine Boyle-Freyssaut, Alice Hadchouel and Christophe Delacourt

    Citation: Respiratory Research 2020 21:43

    Content type: Research

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  28. Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role ...

    Authors: Javier Lázaro, Paloma Clavería, Carmen Cabrejas, José Fernando, Berta Daga, Beatriz Ordoñez, Silvia Segura, David Sanz - Rubio and José M. Marín

    Citation: Respiratory Research 2020 21:42

    Content type: Study protocol

    Published on:

  29. Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor perfor...

    Authors: Inken Padberg, Alice Schneider, Jessica Lee Rohmann, Sean Walter Kelley, Ulrike Grittner and Bob Siegerink

    Citation: Respiratory Research 2020 21:40

    Content type: Research

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  30. Recent studies have shown 6'-O-galloylpaeoniflorin (GPF), a nature product extracted from the roots of paeoniflorin exerts anti-oxidant and anti-inflammatory activities. However, the effects of GPF on the prol...

    Authors: Jinying Gao, Lei Song, Huan Xia, Liping Peng and Zhongmei Wen

    Citation: Respiratory Research 2020 21:39

    Content type: Research

    Published on:

  31. Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a median survival of only three to 5 years. Fibroblast proliferation is a hallmark of IPF as is secretion of extracellular matrix proteins from...

    Authors: Tomohito Yoshihara, Yasuhiro Nanri, Satoshi Nunomura, Yukie Yamaguchi, Carol Feghali-Bostwick, Keiichi Ajito, Shoichi Murakami, Masaaki Mawatari and Kenji Izuhara

    Citation: Respiratory Research 2020 21:38

    Content type: Research

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  32. A persistent low inflammatory-oxidative status and the inadequacy of the antioxidant nuclear factor-E2-related factor 2 (Nrf2) have been implicated in chronic obstructive pulmonary disease (COPD) progression. ...

    Authors: A. M. Fratta Pasini, C. Stranieri, M. Ferrari, U. Garbin, L. Cazzoletti, C. Mozzini, F. Spelta, D. Peserico and L. Cominacini

    Citation: Respiratory Research 2020 21:37

    Content type: Research

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  33. In the Phase III INPULSIS® trials, treatment of patients with idiopathic pulmonary fibrosis (IPF) with nintedanib significantly reduced the annual rate of decline in forced vital capacity (FVC) versus placebo,...

    Authors: Michael Kreuter, Wim A. Wuyts, Marlies Wijsenbeek, Sabrina Bajwah, Toby M. Maher, Susanne Stowasser, Natalia Male, Wibke Stansen, Nils Schoof, Leticia Orsatti and Jeffrey Swigris

    Citation: Respiratory Research 2020 21:36

    Content type: Research

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  34. Obstructive sleep apnea syndrome (OSA) is currently recognized as an independent risk factor for hypertension, arrhythmia, coronary heart disease, stroke, and metabolic disorders (e.g. diabetes, dyslipidemia)....

    Authors: Stephanie André, Fabio Andreozzi, Chloé Van Overstraeten, Sidali Ben Youssef, Ionela Bold, Sarah Carlier, Alexia Gruwez, Anne-Violette Bruyneel and Marie Bruyneel

    Citation: Respiratory Research 2020 21:35

    Content type: Research

    Published on:

  35. After publication of our article [1] the authors have notified us that one of the names has been incorrectly tagged.

    Authors: David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli and Paola Rottoli

    Citation: Respiratory Research 2020 21:34

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:6

  36. Interleukin 15 (IL-15) is a growth and modulating factor for B, T lymphocytes and natural killer cells (NK). Its action on innate and adaptive immunity is modulated by its alpha chain receptor (IL-15Rα). The I...

    Authors: Antoine Moui, Martin Klein, Dorian Hassoun, Eléonore Dijoux, Marie-Aude Cheminant, Antoine Magnan and Grégory Bouchaud

    Citation: Respiratory Research 2020 21:33

    Content type: Research

    Published on:

  37. Fibrotic interstitial lung diseases (ILDs) are often challenging to diagnose and classify, but an accurate diagnosis has significant implications for both treatment and prognosis. A subset of patients with fib...

    Authors: Alyson W. Wong, Christopher J. Ryerson and Sabina A. Guler

    Citation: Respiratory Research 2020 21:32

    Content type: Review

    Published on:

  38. Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a ...

    Authors: Michael J. McGeachie, Joanne E. Sordillo, Amber Dahlin, Alberta L. Wang, Sharon M. Lutz, Kelan G. Tantisira, Ronald Panganiban, Quan Lu, Satria Sajuthi, Cydney Urbanek, Rachel Kelly, Benjamin Saef, Celeste Eng, Sam S. Oh, Alvin T. Kho, Damien C. Croteau-Chonka…

    Citation: Respiratory Research 2020 21:31

    Content type: Research

    Published on:

  39. Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molec...

    Authors: Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2020 21:30

    Content type: Research

    Published on:

  40. After publication of our article [1], we have been notified that an extra alpha symbol (α) was mistakenly added at the beginning of the title.

    Authors: Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser and Manuela Funke-Chambour

    Citation: Respiratory Research 2020 21:29

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:25

  41. Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction be...

    Authors: K. Kahnert, M. Föhrenbach, T. Lucke, P. Alter, F. T. Trudzinski, R. Bals, J. I. Lutter, H. Timmermann, S. Söhler, S. Förderreuther, D. Nowak, H. Watz, B. Waschki, J. Behr, T. Welte, C. F. Vogelmeier…

    Citation: Respiratory Research 2020 21:28

    Content type: Research

    Published on:

  42. Reduced physical capacity (PC) and physical activity (PA) are common in COPD patients and associated with poor outcome. However, they represent different aspects of physical functioning and interventions do no...

    Authors: Noriane A. Sievi, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jörg D. Leuppi, Robert Thurnheer, Malcolm Kohler and Christian F. Clarenbach

    Citation: Respiratory Research 2020 21:27

    Content type: Research

    Published on:

  43. Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resti...

    Authors: Miguel J. Divo, Michael R. DePietro, John R. Horton, Cherie A. Maguire and Bartolome R. Celli

    Citation: Respiratory Research 2020 21:26

    Content type: Research

    Published on:

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