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  1. Assessments of lung function, exacerbations and health status are common measures of chronic obstructive pulmonary disease (COPD) progression and treatment response in clinical trials. We hypothesised that a c...

    Authors: Klaus F. Rabe, David M. G. Halpin, MeiLan K. Han, Marc Miravitlles, Dave Singh, Lars Grönke, Florian Voß and Fernando J. Martinez

    Citation: Respiratory Research 2020 21:177

    Content type: Research

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  2. The interleukin 17 receptor E (IL-17RE) is specific for the epithelial cytokine interleukin-17C (IL-17C). Asthma exacerbations are frequently caused by viral infections. Polyinosinic:polycytidylic acid (pIC) m...

    Authors: Giovanna Vella, Lars Lunding, Felix Ritzmann, Anja Honecker, Christian Herr, Michael Wegmann, Robert Bals and Christoph Beisswenger

    Citation: Respiratory Research 2020 21:176

    Content type: Research

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  3. The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (E...

    Authors: Aradhana Mohan, Stuti Agarwal, Matthias Clauss, Nicholas S. Britt and Navneet K. Dhillon

    Citation: Respiratory Research 2020 21:175

    Content type: Review

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  4. While well-characterised on its molecular base, non-small cell lung cancer (NSCLC) and its interaction with local microbiota remains scarcely explored. Moreover, current studies vary in source of lung microbio...

    Authors: Rea Bingula, Edith Filaire, Ioana Molnar, Eve Delmas, Jean-Yves Berthon, Marie-Paule Vasson, Annick Bernalier-Donadille and Marc Filaire

    Citation: Respiratory Research 2020 21:129

    Content type: Research

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  5. The European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria are widely used in the diagnosis of invasive pulmonary aspergillosis (IPA), but they only apply to immuno...

    Authors: Zhibo Liu, Yuping Li, Xinlun Tian, Qinghua Liu, Erran Li, Xiaoying Gu, Min Liu, Jiuyang Xu, Zhiyi He, Yi Huang, Shuyun Xu, Guoxiang Lai, Yusheng Chen, Xiangyan Zhang, Tiantuo Zhang, Jinfu Xu…

    Citation: Respiratory Research 2020 21:173

    Content type: Research

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  6. Previous studies have shown that Coronavirus Disease 2019 (COVID-19) patients with underlying comorbidities can have worse outcomes. However, the effect of hypertension on outcomes of COVID-19 patients remains...

    Authors: Qing Yang, Ying Zhou, Xinrong Wang, Shan Gao, Yang Xiao, Weiming Zhang, Yi Hu and Yafei Wang

    Citation: Respiratory Research 2020 21:172

    Content type: Research

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  7. There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in ...

    Authors: Mei-ying Wu, Lin Yao, Yi Wang, Xin-yun Zhu, Xia-fang Wang, Pei-jun Tang and Cheng Chen

    Citation: Respiratory Research 2020 21:171

    Content type: Research

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  8. Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seri...

    Authors: Jing Zhang, Zhenxing Zhu, Xu Zuo, He Pan, Yinuo Gu, Yuze Yuan, Guoqiang Wang, Shiji Wang, Ruipeng Zheng, Zhongmin Liu, Fang Wang and Jingtong Zheng

    Citation: Respiratory Research 2020 21:170

    Content type: Review

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  9. Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of deat...

    Authors: Wenjing Ye, Guoxi Chen, Xiaopan Li, Xing Lan, Chen Ji, Min Hou, Di Zhang, Guangwang Zeng, Yaling Wang, Cheng Xu, Weiwei Lu, Ruolin Cui, Yuyang Cai, Hai Huang and Ling Yang

    Citation: Respiratory Research 2020 21:169

    Content type: Research

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  10. Titanium dioxide nanoparticles (TiO2 NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO2 powder are more susce...

    Authors: Shaza Abdulnasser Harfoush, Matthias Hannig, Duc Dung Le, Sebastian Heck, Maximilian Leitner, Albert Joachim Omlor, Isabella Tavernaro, Annette Kraegeloh, Ralf Kautenburger, Guido Kickelbick, Andreas Beilhack, Markus Bischoff, Juliane Nguyen, Martina Sester, Robert Bals and Quoc Thai Dinh

    Citation: Respiratory Research 2020 21:168

    Content type: Research

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  11. Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their anti-proliferative mode of action, we hypothesized ...

    Authors: Anna Birnhuber, Bakytbek Egemnazarov, Valentina Biasin, Ehsan Bonyadi Rad, Malgorzata Wygrecka, Horst Olschewski, Grazyna Kwapiszewska and Leigh M. Marsh

    Citation: Respiratory Research 2020 21:167

    Content type: Letter to the Editor

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  12. Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil...

    Authors: Mike Lonergan, Alison J. Dicker, Megan L. Crichton, Holly R. Keir, Melissa K. Van Dyke, Hana Mullerova, Bruce E. Miller, Ruth Tal-Singer and James D. Chalmers

    Citation: Respiratory Research 2020 21:166

    Content type: Research

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  13. Idiopathic pulmonary fibrosis (IPF) is an incurable disease characterized by progressive lung fibrosis ultimately resulting in respiratory failure and death. Recurrent micro-injuries to the alveolar epithelium...

    Authors: Maximilian Boesch, Florent Baty, Martin H. Brutsche, Michael Tamm, Julien Roux, Lars Knudsen, Amiq Gazdhar, Thomas Geiser, Petra Khan and Katrin E. Hostettler

    Citation: Respiratory Research 2020 21:165

    Content type: Research

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  14. Patients with combined pulmonary fibrosis and emphysema (CPFE) may develop acute exacerbations of IPF (AE-IPF) or COPD (AE-COPD). The incidence and the characteristics of exacerbations in patients with CPFE (e...

    Authors: Massa Zantah, Yaniv Dotan, Chandra Dass, Hauqing Zhao, Nathaniel Marchetti and Gerard J. Criner

    Citation: Respiratory Research 2020 21:164

    Content type: Research

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  15. This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

    Authors: Yiying Huang, Cuiyan Tan, Jian Wu, Meizhu Chen, Zhenguo Wang, Liyun Luo, Xiaorong Zhou, Xinran Liu, Xiaoling Huang, Shican Yuan, Chaolin Chen, Fen Gao, Jin Huang, Hong Shan and Jing Liu

    Citation: Respiratory Research 2020 21:163

    Content type: Research

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  16. Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individual...

    Authors: Ulf Nilsson, Nicholas L. Mills, David A. McAllister, Helena Backman, Caroline Stridsman, Linnea Hedman, Eva Rönmark, Takeshi Fujisawa, Anders Blomberg and Anne Lindberg

    Citation: Respiratory Research 2020 21:162

    Content type: Research

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  17. Cigarette smoke (CS) is a major risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Epithelial-mesenchymal transition (EMT) commonly coexists in lung cancer and COP...

    Authors: Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie and Yicheng Xie

    Citation: Respiratory Research 2020 21:161

    Content type: Research

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  18. Neutrophil is of the most abundant number in human immune system. During acute influenza virus infection, neutrophils are already active in the early phase of inflammation - a time in which clinical biopsy or ...

    Authors: Louisa L. Y. Chan, John M. Nicholls, J. S. Malik Peiris, Yu Lung Lau, Michael C. W. Chan and Renee W. Y. Chan

    Citation: Respiratory Research 2020 21:160

    Content type: Research

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  19. Acute pulmonary embolism remains a significant cause of mortality and morbidity worldwide. Benefit of recently developed multidisciplinary PE response teams (PERT) with higher utilization of advanced therapies...

    Authors: Lukasz A. Myc, Jigna N. Solanki, Andrew J. Barros, Nebil Nuradin, Matthew G. Nevulis, Kranthikiran Earasi, Emily D. Richardson, Shawn C. Tsutsui, Kyle B. Enfield, Nicholas R. Teman, Ziv J. Haskal, Sula Mazimba, Jamie L. W. Kennedy, Andrew D. Mihalek, Aditya M. Sharma and Alexandra Kadl

    Citation: Respiratory Research 2020 21:159

    Content type: Research

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  20. Chronic obstructive pulmonary disease (COPD) clinical trials aimed at evaluating treatment effects on exacerbations often suffer from early discontinuations of randomized treatment. Treatment discontinuations ...

    Authors: Agnieszka Król, Robert Palmér, Virginie Rondeau, Stephen Rennard, Ulf G. Eriksson and Alexandra Jauhiainen

    Citation: Respiratory Research 2020 21:158

    Content type: Research

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  21. Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

    Authors: Changzhi Zhou, Zhe Huang, Weijun Tan, Xueying Li, Wen Yin, Yang Xiao, Zhaowu Tao, Shuang Geng and Yi Hu

    Citation: Respiratory Research 2020 21:157

    Content type: Research

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  22. Clinical questionnaires are mainly applied as screening tools for identification of the Obstructive sleep apnea (OSA) patients. Little attention has been paid to assess the body functions and health status of ...

    Authors: Liang Xie, Qinhan Wu, Weiping Hu, Wenjing Li, Guiling Xiang, Shengyu Hao, Chengyao Guo, Hong Jiang, Xiaodan Wu, Xu Wu and Shanqun Li

    Citation: Respiratory Research 2020 21:156

    Content type: Research

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  23. Asthma is a common and heterogeneous disease that includes subgroups characterized by type 2 (T2) or type 17 (T17) immune responses for which there is a need to identify the underlying mechanisms and biomarker...

    Authors: Elisabeth Ax, Zala Jevnikar, Aleksander Cvjetkovic, Carina Malmhäll, Henric Olsson, Madeleine Rådinger and Cecilia Lässer

    Citation: Respiratory Research 2020 21:155

    Content type: Research

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  24. Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

    Authors: Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough and Irfan Rahman

    Citation: Respiratory Research 2020 21:154

    Content type: Research

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  25. Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic fa...

    Authors: Kiyoharu Fukushima, Mari Miki, Yuki Matsumoto, Emi Uda, Yuji Yamamoto, Yuya Kogita, Yuko Kagawa, Takanori Matsuki, Hiroyuki Kagawa, Yohei Oshitani, Daisuke Motooka, Kazuyuki Tsujino, Kenji Yoshimura, Keisuke Miki, Akio Hayashi, Shota Nakamura…

    Citation: Respiratory Research 2020 21:153

    Content type: Research

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  26. In the recent years, the overall trends in hospital admission and mortality of interstitial lung disease (ILD) are unknown. In addition, there was some evidence that interstitial lung disease death rate highes...

    Authors: An Thi Nhat Ho, Artem Shmelev and Edward Charbek

    Citation: Respiratory Research 2020 21:152

    Content type: Research

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  27. Both short sleep duration and obstructive sleep apnea (OSA) seem to be associated with insulin resistance. We aimed to explore whether short sleep duration modifies the relationship between OSA and insulin res...

    Authors: Huajun Xu, Chen Liang, Jianyin Zou, Hongliang Yi, Jian Guan, Meizhen Gu, Yanhong Feng and Shankai Yin

    Citation: Respiratory Research 2020 21:151

    Content type: Research

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  28. In study “Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study” by Tung et al., authors concluded HFNT utilization led to enhanced ...

    Authors: Guillaume Prieur, Yann Combret and Clement Medrinal

    Citation: Respiratory Research 2020 21:150

    Content type: Letter to the Editor

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  29. Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung in preclinical and human models of neutrophilic airway inflammation. A previous stud...

    Authors: Aili L. Lazaar, Bruce E. Miller, Alison C. Donald, Thomas Keeley, Claire Ambery, John Russell, Henrik Watz and Ruth Tal-Singer

    Citation: Respiratory Research 2020 21:149

    Content type: Research

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  30. Patients with asthma uncontrolled on inhaled corticosteroids may benefit from umeclidinium (UMEC), a long-acting muscarinic antagonist.

    Authors: Edward Kerwin, Steven Pascoe, Zelie Bailes, Robert Nathan, David Bernstein, Ronald Dahl, Robyn von Maltzahn, Kevin Robbins, Andrew Fowler and Laurie Lee

    Citation: Respiratory Research 2020 21:148

    Content type: Research

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  31. The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight i...

    Authors: Qi Guo, Wei-dong Song, Wei Li, Chao Zeng, Yan-hong Li, Jian-ming Mo, Zhong-dong Lü and Mei Jiang

    Citation: Respiratory Research 2020 21:147

    Content type: Research

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  32. The endogenous secretory receptor for advanced glycation end products (esRAGE) is a soluble isoform produced by alternative splicing of the RAGE gene. The isoform has anti-inflammatory properties due to its in...

    Authors: Kakuhiro Yamaguchi, Hiroshi Iwamoto, Witold Mazur, Shinichiro Miura, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori

    Citation: Respiratory Research 2020 21:145

    Content type: Research

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  33. Acute lung injury (ALI) is a highly lethal pulmonary disease that causes edema, hypoxemia and respiratory failure. Recent evidence indicates that nuclear factor-kappa B (NF-κB) plays a crucial role in ALI deve...

    Authors: Ruidong Chen, Fei Xie, Jie Zhao and Bin Yue

    Citation: Respiratory Research 2020 21:144

    Content type: Research

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  34. Periostin is a matricellular protein and is a useful marker in respiratory diseases. However, the roles of periostin in patients with obstructive sleep apnea (OSA) remain unclear. Several in vitro studies have...

    Authors: Hironobu Sunadome, Hisako Matsumoto, Ryo Tachikawa, Takeshi Matsumoto, Kiminobu Tanizawa, Toru Oga, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Toyohiro Hirai and Kazuo Chin

    Citation: Respiratory Research 2020 21:143

    Content type: Research

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  35. The rate of diagnosis of advanced lung adenocarcinoma must be improved. In this study, we compared the detection rates of EGFR-tyrosine kinase inhibitor-sensitizing mutations (mEGFRs) in bronchial washing flui...

    Authors: Sang Hoon Lee, Eun Young Kim, Taehee Kim and Yoon Soo Chang

    Citation: Respiratory Research 2020 21:142

    Content type: Research

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  36. Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immu...

    Authors: E. Beijer, B. Meek, X. Bossuyt, S. Peters, R. C. H. Vermeulen, H. Kromhout and M. Veltkamp

    Citation: Respiratory Research 2020 21:141

    Content type: Research

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  37. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal model, alveolar simplification and pro-inflammato...

    Authors: Shangqin Chen, Qiuping Wu, Dingjuan Zhong, Changchong Li and Lizhong Du

    Citation: Respiratory Research 2020 21:140

    Content type: Research

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  38. This analysis of the IMPACT study assessed the cardiovascular (CV) safety of single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus FF/VI and UMEC/VI dual therapy.

    Authors: Nicola C. Day, Subramanya Kumar, Gerard Criner, Mark Dransfield, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Morrys C. Kaisermann, Sally Kilbride, Peter Lange, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert Wise and David A. Lipson

    Citation: Respiratory Research 2020 21:139

    Content type: Research

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  39. Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated w...

    Authors: Cristóbal Esteban, Inmaculada Arostegui, Amaia Aramburu, Javier Moraza, Josu Najera-Zuloaga, Myriam Aburto, Susana Aizpiri, Leyre Chasco and José M. Quintana

    Citation: Respiratory Research 2020 21:138

    Content type: Research

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  40. Treatment of Chronic Obstructive Pulmonary Disease (COPD) is based on bronchodilation, with inhaled corticosteroids or azithromycin associated when frequent exacerbations occur. Despite the proven benefits of ...

    Authors: Carolien Mathyssen, Celine Aelbrecht, Jef Serré, Stephanie Everaerts, Karen Maes, Ghislaine Gayan-Ramirez, Bart Vanaudenaerde and Wim Janssens

    Citation: Respiratory Research 2020 21:137

    Content type: Research

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  41. Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. T...

    Authors: Balram Neupane, Akylbek Sydykov, Kabita Pradhan, Christina Vroom, Christiane Herden, Srikanth Karnati, Hossein Ardeschir Ghofrani, Sergey Avdeev, Süleyman Ergün, Ralph Theo Schermuly and Djuro Kosanovic

    Citation: Respiratory Research 2020 21:136

    Content type: Research

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  42. Given the heterogeneity of chronic obstructive pulmonary disease (COPD), personalized clinical management is key to optimizing patient outcomes. Important treatment goals include minimizing disease activity an...

    Authors: Dave Singh, Gerard J. Criner, Ian Naya, Paul W. Jones, Lee Tombs, David A. Lipson and MeiLan K. Han

    Citation: Respiratory Research 2020 21:134

    Content type: Review

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  43. Lumacaftor/ivacaftor (LUM/IVA) modestly improves lung function following 1 month of treatment but it is unknown if this translates into improvements in exercise endurance and exertional symptoms.

    Authors: Bradley S. Quon, Andrew H. Ramsook, Satvir S. Dhillon, Reid A. Mitchell, Kyle G. Boyle, Pearce G. Wilcox and Jordan A. Guenette

    Citation: Respiratory Research 2020 21:135

    Content type: Letter to the Editor

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  44. Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tom...

    Authors: Taewoo Kim, Hyun Bin Cho, Woo Jin Kim, Chang Hyun Lee, Kum Ju Chae, So-Hyun Choi, Kyeong Eun Lee, So Hyeon Bak, Sung Ok Kwon, Gong Yong Jin, Jiwoong Choi, Eun-Kee Park, Ching-Long Lin, Eric A. Hoffman and Sanghun Choi

    Citation: Respiratory Research 2020 21:133

    Content type: Research

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  45. Chronic tissue injury was shown to induce progressive scarring in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), while an array of repair/regeneration and stress responses come to equilibrium t...

    Authors: Xiaofei Cong, Nagaraja Nagre, Jeremy Herrera, Andrew C. Pearson, Ian Pepper, Robell Morehouse, Hong-Long Ji, Dianhua Jiang, Rolf D. Hubmayr and Xiaoli Zhao

    Citation: Respiratory Research 2020 21:132

    Content type: Research

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  46. The comparative efficacy of inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) triple therapy administered via single or multiple inhalers in patients with chronic obs...

    Authors: Gary T. Ferguson, Nicola Brown, Chris Compton, Thomas C. Corbridge, Kelly Dorais, Charles Fogarty, Catherine Harvey, Morrys C. Kaisermann, David A. Lipson, Neil Martin, Frank Sciurba, Marjorie Stiegler, Chang-Qing Zhu and David Bernstein

    Citation: Respiratory Research 2020 21:131

    Content type: Research

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  47. It has been confirmed that NF-κB p65 signaling pathway is involved in the regulation of alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome (ARDS). Whether SN50, a NF-κ...

    Authors: Yanqi Wu, Yahui Wang, Bo Liu, Yumei Cheng, Hong Qian, Huilin Yang, Xiang Li, Guixia Yang, Xinghao Zheng and Feng Shen

    Citation: Respiratory Research 2020 21:130

    Content type: Research

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  48. The Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting bronchodilator for chronic obstructive pulmonary disease...

    Authors: Fernando J. Martinez, Brian J. Lipworth, Klaus F. Rabe, David J. Collier, Gary T. Ferguson, Sanjay Sethi, Gregory J. Feldman, Gerald O’Brien, Martin Jenkins and Colin Reisner

    Citation: Respiratory Research 2020 21:128

    Content type: Research

    Published on:

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