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  1. Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced incre...

    Authors: Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight, Delbert R. Dorscheid, Tillie L. Hackett, Michael R. Hughes, Kelly M. McNagny, Jeremy A. Hirota, Masahiro Niikura, S. F. Paul Man and Don D. Sin

    Citation: Respiratory Research 2021 22:75

    Content type: Research

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  2. The pathophysiology of chronic obstructive pulmonary disease (COPD) relies on airway remodelling and inflammation. Alterations of mucociliary clearance are a major hallmark of COPD caused by structural and fun...

    Authors: Jeanne-Marie Perotin, Myriam Polette, Gaëtan Deslée and Valérian Dormoy

    Citation: Respiratory Research 2021 22:74

    Content type: Letter to the Editor

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  3. The mechanism for spread of SARS-CoV-2 has been attributed to large particles produced by coughing and sneezing. There is controversy whether smaller airborne particles may transport SARS-CoV-2. Smaller partic...

    Authors: Rebecca A. Stern, Petros Koutrakis, Marco A. G. Martins, Bernardo Lemos, Scot E. Dowd, Elsie M. Sunderland and Eric Garshick

    Citation: Respiratory Research 2021 22:73

    Content type: Research

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  4. Chlamydia pneumoniae and Mycoplasma pneumoniae have been implicated in the pathogenesis of asthma and are responsible for chronic inflammation when host immune system fails to eradicate the bacteria.

    Authors: Doriane Calmes, Pascale Huynen, Virginie Paulus, Monique Henket, Françoise Guissard, Catherine Moermans, Renaud Louis and Florence Schleich

    Citation: Respiratory Research 2021 22:72

    Content type: Research

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  5. Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) represents one of the most challenging scenarios for aerosol medicine. This challenge is highlighted by the undersized anato...

    Authors: Federico Bianco, Fabrizio Salomone, Ilaria Milesi, Xabier Murgia, Sauro Bonelli, Elena Pasini, Raffaele Dellacà, Maria Luisa Ventura and Jane Pillow

    Citation: Respiratory Research 2021 22:71

    Content type: Review

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  6. Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored.

    Authors: Tianshi David Wu, Ashraf Fawzy, Gregory L. Kinney, Jessica Bon, Maniraj Neupane, Vickram Tejwani, Nadia N. Hansel, Robert A. Wise, Nirupama Putcha and Meredith C. McCormack

    Citation: Respiratory Research 2021 22:70

    Content type: Research

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  7. CD34, a pan-selectin binding protein when glycosylated, has been shown to be involved in leukocyte migration to the site of inflammation. However, only one report is available on the expression and role of CD3...

    Authors: Gurpreet K. Aulakh, Sushmita Maltare and Baljit Singh

    Citation: Respiratory Research 2021 22:69

    Content type: Research

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  8. Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reli...

    Authors: Liang-Yuan Li, Tian-Sheng Yan, Jing Yang, Yu-Qi Li, Lin-Xi Fu, Lan Lan, Bin-Miao Liang, Mao-Yun Wang and Feng-Ming Luo

    Citation: Respiratory Research 2021 22:68

    Content type: Research

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  9. Infection with Haemophilus influenzae (Hi) or Moraxella catarrhalis (Mcat) is a risk factor for exacerbation in chronic obstructive pulmonary disease (COPD). The ability to predict Hi- or Mcat-associated exacerba...

    Authors: Lucio Malvisi, Laura Taddei, Aparna Yarraguntla, Tom M. A. Wilkinson and Ashwani Kumar Arora

    Citation: Respiratory Research 2021 22:67

    Content type: Research

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  10. FIBRONET was an observational, multicentre, prospective cohort study investigating the baseline characteristics, clinical course of disease and use of antifibrotic treatment in Italian patients with idiopathic...

    Authors: V. Poletti, C. Vancheri, C. Albera, S. Harari, A. Pesci, R. R. Metella, B. Campolo, G. Crespi and S. Rizzoli

    Citation: Respiratory Research 2021 22:66

    Content type: Research

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  11. Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased effica...

    Authors: Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin and Delbert R. Dorscheid

    Citation: Respiratory Research 2021 22:65

    Content type: Research

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  12. Beta-blockers are associated with reduced mortality in patients with cardiovascular disease but are often under prescribed in those with concomitant COPD, due to concerns regarding respiratory side-effects. We...

    Authors: Claudia Gulea, Rosita Zakeri, Vanessa Alderman, Alexander Morgan, Jack Ross and Jennifer K. Quint

    Citation: Respiratory Research 2021 22:64

    Content type: Review

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  13. The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of asthma. However, the role of mitochondr...

    Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose…

    Citation: Respiratory Research 2021 22:63

    Content type: Research

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  14. Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung reducing clinical consequences of cholinergic hyperactivity. The AIRFLOW-1 study...

    Authors: Pison Christophe, L. Shah Pallav, Slebos Dirk-Jan, Ninane Vincent, Janssens Wim, Perez Thierry, Kessler Romain, Deslee Gaetan, L. Garner Justin, E. Hartman Jorine, Degano Bruno, Mayr Anna, Mayse Martin, D. Peterson Alexander and Valipour Arschang

    Citation: Respiratory Research 2021 22:62

    Content type: Research

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  15. Rapid response system (RRS) is being increasingly adopted to improve patient safety in hospitals worldwide. However, predictors of survival outcome after RRS activation because of unexpected clinical deteriora...

    Authors: Jimyung Park, Yeon Joo Lee, Sang-Bum Hong, Kyeongman Jeon, Jae Young Moon, Jung Soo Kim, Byung Ju Kang, Jong-Joon Ahn, Dong-Hyun Lee, Jisoo Park, Jae Hwa Cho and Sang-Min Lee

    Citation: Respiratory Research 2021 22:60

    Content type: Research

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  16. Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.

    Authors: Wenjia Chen, Mohsen Sadatsafavi, J. Mark FitzGerald, Larry D. Lynd and Don D. Sin

    Citation: Respiratory Research 2021 22:59

    Content type: Research

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  17. An adverse role for obstructive sleep apnea (OSA) in cancer aggressiveness and mortality has recently emerged from clinical and animal studies, and the reasons have not been fully determined. Cancer stem cells...

    Authors: Shengyu Hao, Xiaodan Zhu, Zilong Liu, Xiaodan Wu, Shanqun Li, Pan Jiang and Liyan Jiang

    Citation: Respiratory Research 2021 22:58

    Content type: Research

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  18. MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants w...

    Authors: Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan and Charitharth Vivek Lal

    Citation: Respiratory Research 2021 22:57

    Content type: Research

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  19. Chronic obstructive pulmonary disease (COPD) has been proposed as a disease of accelerated aging. Several cross-sectional studies have related a shorter telomere length (TL), a marker of biological aging, with...

    Authors: E. Córdoba-Lanús, S. Cazorla-Rivero, M. A. García-Bello, D. Mayato, F. Gonzalvo, J. Ayra-Plasencia, B. Celli and C. Casanova

    Citation: Respiratory Research 2021 22:56

    Content type: Research

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  20. Which patients should receive dual therapy as initial treatment for chronic obstructive pulmonary disease (COPD) is only loosely defined. We evaluated if a lower forced expiratory volume in 1 s (FEV1) identifies ...

    Authors: Jieun Kang, Jae Seung Lee, Sei Won Lee, Jung Bok Lee and Yeon-Mok Oh

    Citation: Respiratory Research 2021 22:55

    Content type: Research

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  21. Inhaled corticosteroid (ICS) therapy for COPD should be guided by exacerbations and blood-eosinophils according to the GOLD 2020 strategy document. In the present study, we applied these recent recommendations...

    Authors: Osman Savran, Nina Godtfredsen, Torben Sørensen, Christian Jensen and Charlotte Suppli Ulrik

    Citation: Respiratory Research 2021 22:54

    Content type: Research

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  22. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. Several risk factors such as smoking, air pollution, inhaled toxins, high body mass index and infectious agents are involved in the pa...

    Authors: Shayan Mostafaei, Babak Sayad, Maryam Ebadi Fard Azar, Mohammad Doroudian, Shima Hadifar, Ava Behrouzi, Parisa Riahi, Bashdar Mahmud Hussen, Bahareh Bayat, Javid Sadri Nahand and Mohsen Moghoofei

    Citation: Respiratory Research 2021 22:53

    Content type: Review

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  23. Chinese Yunnan Province, located in the Yunnan–Guizhou Plateau, is a famous tourist paradise where acute high-altitude illness common occurs among lowland people visitors due to non-acclimatization to the acut...

    Authors: Xing Fu, Chunyan Yang, Bing Chen, Kexing Zeng, Siyuan Chen and Yi Fu

    Citation: Respiratory Research 2021 22:52

    Content type: Research

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  24. Little is known on the role of transient receptor potential ankyrin 1 (TRPA1) in fibroblast—myofibroblast transition (FMT) that can lead to airway remodeling which is a major problem for severe asthma and fibr...

    Authors: Jennifer Maries Go Yap, Takashi Ueda, Yoshihiro Kanemitsu, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Testsuya Oguri, Shinya Ugawa and Akio Niimi

    Citation: Respiratory Research 2021 22:51

    Content type: Research

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  25. The importance of vaccinations for COPD patients has been previously described. However, there is still a gap between guideline recommendations and the implementation of preventive care delivery for these pati...

    Authors: Solmaz Ehteshami-Afshar, Kristina Crothers, Benjamin Rodwin, Brett Bade, Cynthia Brandt and Kathleen M. Akgün

    Citation: Respiratory Research 2021 22:50

    Content type: Letter to the Editor

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  26. Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndr...

    Authors: Karina Cuevas-Mora, Willy Roque, Hoora Shaghaghi, Bernadette R. Gochuico, Ivan O. Rosas, Ross Summer and Freddy Romero

    Citation: Respiratory Research 2021 22:49

    Content type: Research

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  27. Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to as...

    Authors: Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens and Loes E. M. Kistemaker

    Citation: Respiratory Research 2021 22:48

    Content type: Research

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  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock and Kian Fan Chung

    Citation: Respiratory Research 2021 22:47

    Content type: Correction

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    The original article was published in Respiratory Research 2021 22:10

  29. Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathoge...

    Authors: Yaping Wang, Kou Liao, Bo Liu, Chao Niu, Wenjing Zou, Lili Yang, Ting Wang, Daiyin Tian, Zhengxiu Luo, Jihong Dai, Qubei Li, Enmei Liu, Caihui Gong, Zhou Fu, Ying Li and Fengxia Ding

    Citation: Respiratory Research 2021 22:46

    Content type: Research

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  30. S100 calcium binding protein A9 (S100A9) is a pro-inflammatory alarmin associated with several inflammation-related diseases. However, the role of S100A9 in lung injury in sepsis has not been fully investigate...

    Authors: Boying Zhao, Renfu Lu, Jianjun Chen, Ming Xie, Xingji Zhao and Lingwen Kong

    Citation: Respiratory Research 2021 22:45

    Content type: Research

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  31. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung diseases with a poor prognosis. Long non-coding RNAs (lncRNAs) have been reported to be involved in IPF in several studies. However, the...

    Authors: Panpan Liu, Lei Zhao, Yuxia Gu, Meilan Zhang, Hongchang Gao and Yingxia Meng

    Citation: Respiratory Research 2021 22:44

    Content type: Research

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  32. The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) is heterogenous depending on the characterized sources of inflammation. This study aimed to evaluate COPD phenotypes a...

    Authors: Junghyun Kim, Bom Kim, So Hyeon Bak, Yeon-Mok Oh and Woo Jin Kim

    Citation: Respiratory Research 2021 22:43

    Content type: Research

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  33. Alveolar epithelial cells play an essential role in the initiation and progression of pulmonary fibrosis, and the occurrence of epithelial–mesenchymal transition (EMT) may be the early events of pulmonary fibr...

    Authors: Zhenzhen Ma, Chunyan Ma, Qingfeng Zhang, Yang Bai, Kun Mu, Xiangyuan Liu and Qingrui Yang

    Citation: Respiratory Research 2021 22:42

    Content type: Research

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  34. Childhood asthma and allergic diseases are a significant global problem. There are inconsistent findings on the associations of delivery mode, the number of children in the household and breastfeeding with chi...

    Authors: Yabin Hu, Yiting Chen, Shijian Liu, Fan Jiang, Meiqin Wu, Chonghuai Yan, Jianguo Tan, Guangjun Yu, Yi Hu, Yong Yin, Jiajie Qu, Shenghui Li and Shilu Tong

    Citation: Respiratory Research 2021 22:41

    Content type: Research

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  35. Observational data under real-life conditions in idiopathic pulmonary fibrosis (IPF) is scarce. We explored anti-fibrotic treatment, disease severity and phenotypes in patients with IPF from the Swedish IPF Re...

    Authors: Jing Gao, Dimitrios Kalafatis, Lisa Carlson, Ida H. A. Pesonen, Chuan-Xing Li, Åsa Wheelock, Jesper M. Magnusson and C. Magnus Sköld

    Citation: Respiratory Research 2021 22:40

    Content type: Research

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  36. Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 i...

    Authors: D. J. Leeming, F. Genovese, J. M. B. Sand, D. G. K. Rasmussen, C. Christiansen, G. Jenkins, T. M. Maher, J. Vestbo and M. A. Karsdal

    Citation: Respiratory Research 2021 22:38

    Content type: Commentary

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  37. Comorbidities play a key role in severe disease outcomes in COVID-19 patients. However, the literature on preexisting respiratory diseases and COVID-19, accounting for other possible confounders, is limited. T...

    Authors: Prateek Lohia, Kalyan Sreeram, Paul Nguyen, Anita Choudhary, Suman Khicher, Hossein Yarandi, Shweta Kapur and M. Safwan Badr

    Citation: Respiratory Research 2021 22:37

    Content type: Research

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  38. Control in COPD is a dynamic concept that can reflect changes in patients’ clinical status that may have prognostic implications, but there is no information about changes in control status and its long-term c...

    Authors: Myriam Calle Rubio, Juan Luis Rodriguez Hermosa, Juan P. de Torres, José María Marín, Cristina Martínez-González, Antonia Fuster, Borja G. Cosío, Germán Peces-Barba, Ingrid Solanes, Nuria Feu-Collado, Jose Luis Lopez-Campos and Ciro Casanova

    Citation: Respiratory Research 2021 22:36

    Content type: Research

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  39. Although the prevalence of bronchial asthma has been increasing worldwide since the 1970′s, the prevalence among 5-year-old children was significantly lower in 2016 than in 2001 in rural Bangladesh. We aimed t...

    Authors: Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata and Md Alfazal Khan

    Citation: Respiratory Research 2021 22:35

    Content type: Research

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  40. The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypertension (PAH). Treatment interruptions should be avoided due to the progressive nature of the disease. ...

    Authors: Hans Klose, Kelly M. Chin, Ralf Ewert, Henning Gall, Joseph Parambil, David Poch, Hans-Jürgen Seyfarth, Lene N. Axelsen, Shu-Fang Hsu Schmitz, Claudia Stein and Ioana R. Preston

    Citation: Respiratory Research 2021 22:34

    Content type: Research

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  41. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) carry significant morbidity and mortality. AECOPD treatment remains limited. High molecular weight hyaluronan (HMW-HA) is a glycosaminoglyc...

    Authors: Flavia Galdi, Claudio Pedone, Christopher A. McGee, Margaret George, Annette B. Rice, Shah S. Hussain, Kadambari Vijaykumar, Evan R. Boitet, Guillermo J. Tearney, John A. McGrath, Audrey R. Brown, Steven M. Rowe, Raffaele A. Incalzi and Stavros Garantziotis

    Citation: Respiratory Research 2021 22:30

    Content type: Research

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  42. Pulmonary rehabilitation (PR) has been proposed as an effective method for many respiratory diseases. However, the effects of exercise-based PR on asthma are currently inconclusive. This review aimed to invest...

    Authors: Zhenzhen Feng, Jiajia Wang, Yang Xie and Jiansheng Li

    Citation: Respiratory Research 2021 22:33

    Content type: Review

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  43. Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of S...

    Authors: Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Ellen Pierre de Oliveira, Jose Mara de Brito, Ellen Caroline Toledo do Nascimento, Renata Aparecida de Almeida Monteiro, Juliana Carvalho Ferreira, Carlos Roberto Ribeiro de Carvalho, Paulo Hilário do Nascimento Saldiva and Marisa Dolhnikoff

    Citation: Respiratory Research 2021 22:32

    Content type: Research

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  44. Epithelial solitary chemosensory cell (tuft cell) bitter taste signal transduction occurs through G protein coupled receptors and calcium-dependent signaling pathways. Type II taste cells, which utilize the sa...

    Authors: Michael A. Kohanski, Lauren Brown, Melissa Orr, Li Hui Tan, Nithin D. Adappa, James N. Palmer, Ronald C. Rubenstein and Noam A. Cohen

    Citation: Respiratory Research 2021 22:31

    Content type: Research

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  45. Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is rel...

    Authors: Laurent Truffaut, Lucas Demey, Anne Violette Bruyneel, Alain Roman, Stephane Alard, Nathalie De Vos and Marie Bruyneel

    Citation: Respiratory Research 2021 22:29

    Content type: Letter to the Editor

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  46. Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...

    Authors: Thomas Sonnweber, Eva-Maria Schneider, Manfred Nairz, Igor Theurl, Günter Weiss, Piotr Tymoszuk and Judith Löffler-Ragg

    Citation: Respiratory Research 2021 22:28

    Content type: Research

    Published on:

  47. The epithelial-mesenchymal signaling involving SHH-FOXF1, TBX4-FGF10, and TBX2 pathways is an essential transcriptional network operating during early lung organogenesis. However, precise regulatory interactio...

    Authors: Justyna A. Karolak, Tomasz Gambin, Przemyslaw Szafranski and Paweł Stankiewicz

    Citation: Respiratory Research 2021 22:26

    Content type: Research

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  48. Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in ord...

    Authors: Helgo Magnussen, Sarah Lucas, Therese Lapperre, Jennifer K. Quint, Ronald J. Dandurand, Nicolas Roche, Alberto Papi, David Price and Marc Miravitlles

    Citation: Respiratory Research 2021 22:25

    Content type: Research

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