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  1. Airway mucus hypersecretion is an important pathophysiological feature in asthma. Mucins are glycoproteins that are mainly responsible for the viscoelastic property of mucus, and MUC5AC is a major mucin glycop...

    Authors: Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Juan Liu, Rong-Fei Sun, Xue-Jiao Qian and Jiang-Bo Liu

    Citation: Respiratory Research 2019 20:282

    Content type: Research

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  2. Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has bee...

    Authors: Wei Liu, Jeffrey A. Meridew, Aja Aravamudhan, Giovanni Ligresti, Daniel J. Tschumperlin and Qi Tan

    Citation: Respiratory Research 2019 20:281

    Content type: Research

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  3. There is currently no method that can predict whether or under what condition hypopnea, even obstructive sleep apnea (OSA), will occur during sleep for individuals based on credible parameters measured under w...

    Authors: Hongyi Lin, Cunting Wang, Han Zhang, Huahui Xiong, Zheng Li, Xiaoqing Huang, Changjin Ji, Junfang Xian and Yaqi Huang

    Citation: Respiratory Research 2019 20:280

    Content type: Research

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  4. Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical paramet...

    Authors: Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee and Ji Ye Jung

    Citation: Respiratory Research 2019 20:279

    Content type: Research

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  5. Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). T...

    Authors: Léo Blervaque, Emilie Passerieux, Pascal Pomiès, Matthias Catteau, Nelly Héraud, Marine Blaquière, François Bughin, Bronia Ayoub, Nicolas Molinari, Jean-Paul Cristol, Antonia Perez-Martin, Jacques Mercier, Maurice Hayot and Fares Gouzi

    Citation: Respiratory Research 2019 20:278

    Content type: Research

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  6. Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and no...

    Authors: Hannah R. Whittaker, Debbie Jarvis, Mohamed R. Sheikh, Steven J. Kiddle and Jennifer K. Quint

    Citation: Respiratory Research 2019 20:277

    Content type: Review

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  7. Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scal...

    Authors: Xinyi Li, Hengye Huang, Huajun Xu, Yue Shi, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan and Shankai Yin

    Citation: Respiratory Research 2019 20:276

    Content type: Research

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  8. Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasi...

    Authors: Hélène Goussault, Hélène Salvator, Emilie Catherinot, Marie-Laure Chabi, Colas Tcherakian, Alexandre Chabrol, Morgane Didier, Elisabeth Rivaud, Alain Fischer, Felipe Suarez, Olivier Hermine, Fanny Lanternier, Olivier Lortholary, Nizar Mahlaoui, Philippe Devillier and Louis-Jean Couderc

    Citation: Respiratory Research 2019 20:275

    Content type: Research

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  9. By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also co...

    Authors: Zhenglong Chen, Ming Zhong, Yuzhou Luo, Linhong Deng, Zhaoyan Hu and Yuanlin Song

    Citation: Respiratory Research 2019 20:274

    Content type: Review

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  10. Poor medication-adherence is common in chronic lung patients, resulting in reduced health-outcomes and increased healthcare-costs. This study aimed to investigate the impact of an acoustic reminder and support...

    Authors: Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Stéphanie Giezendanner, Sabrina Maier, Anne Leuppi-Taegtmeyer, Isabelle Arnet, Kurt E. Hersberger and Jörg D. Leuppi

    Citation: Respiratory Research 2019 20:273

    Content type: Research

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  11. Lower respiratory tract (LRT) microbiome has been reported to associate with pulmonary diseases. Unregulated inflammation is an underlying cause of variable lung diseases. The lung microbiome may play an impor...

    Authors: Kang-jie Li, Zi-long Chen, Yao Huang, Rui Zhang, Xiao-qian Luan, Ting-ting Lei and Ling Chen

    Citation: Respiratory Research 2019 20:272

    Content type: Research

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  12. All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with br...

    Authors: Sooim Sin, Seo Young Yun, Jee Min Kim, Chang Min Park, Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Chang-Hoon Lee

    Citation: Respiratory Research 2019 20:271

    Content type: Research

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  13. Protein tyrosine kinase 2 (PTK2) expression has been reported in various types of human epithelial cancers including lung cancer; however, the role of PTK2 in epidermal growth factor receptor (EGFR)-mutant non...

    Authors: Xuexia Tong, Ryosuke Tanino, Rong Sun, Yukari Tsubata, Tamio Okimoto, Mayumi Takechi and Takeshi Isobe

    Citation: Respiratory Research 2019 20:270

    Content type: Research

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  14. Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is u...

    Authors: Rachel N. Criner, Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, Neil R. MacIntyre, Barry J. Make, Fernando J. Martinez, Wassim W. Labaki, Jeffrey L. Curtis and Mei Lan K. Han

    Citation: Respiratory Research 2019 20:269

    Content type: Letter to the Editor

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  15. Active smoking is the main risk factor for COPD. Here, epigenetic mechanisms may play a role, since cigarette smoking is associated with differential DNA methylation in whole blood. So far, it is unclear wheth...

    Authors: Maaike de Vries, Ivana Nedeljkovic, Diana A. van der Plaat, Alexandra Zhernakova, Lies Lahousse, Guy G. Brusselle, Najaf Amin, Cornelia M. van Duijn, Judith M. Vonk and H. Marike Boezen

    Citation: Respiratory Research 2019 20:268

    Content type: Research

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  16. Our earlier report indicated that active vitamin D3 inhibited epithelial-mesenchymal transition (EMT) in bleomycin (BLM)-induced pulmonary fibrosis. The objective of this study was to further investigate wheth...

    Authors: Se-Ruo Li, Zhu-Xia Tan, Yuan-Hua Chen, Biao Hu, Cheng Zhang, Hua Wang, Hui Zhao and De-Xiang Xu

    Citation: Respiratory Research 2019 20:266

    Content type: Research

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  17. Metagenomic sequencing of respiratory microbial communities for pathogen identification in pneumonia may help overcome the limitations of culture-based methods. We examined the feasibility and clinical validit...

    Authors: Libing Yang, Ghady Haidar, Haris Zia, Rachel Nettles, Shulin Qin, Xiaohong Wang, Faraaz Shah, Sarah F. Rapport, Themoula Charalampous, Barbara Methé, Adam Fitch, Alison Morris, Bryan J. McVerry, Justin O’Grady and Georgios D. Kitsios

    Citation: Respiratory Research 2019 20:265

    Content type: Research

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  18. Impaired mitochondria homeostasis and function are established hallmarks of aging and increasing evidence suggests a link with lung fibrosis. Mitochondria homeostasis may be also affected in alveolar macrophag...

    Authors: Eliza Tsitoura, Eirini Vasarmidi, Eleni Bibaki, Athina Trachalaki, Chara Koutoulaki, George Papastratigakis, Sevasti Papadogiorgaki, George Chalepakis, Nikos Tzanakis and Katerina M. Antoniou

    Citation: Respiratory Research 2019 20:264

    Content type: Research

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  19. Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We...

    Authors: Takuya Aoki, Takeshi Akiba, Jun Nishiyama, Sakurako Tajiri, Naoki Hayama, Genki Takahashi, Jun Tanaka, Masako Sato, Hiroto Takiguchi, Hiromi Tomomatsu, Katsuyoshi Tomomatsu, Takahisa Takihara, Kyoko Niimi, Tsuyoshi Oguma, Mitsutomo Kohno, Ryota Masuda…

    Citation: Respiratory Research 2019 20:263

    Content type: Research

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  20. Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome of primary pulmonary LELC were...

    Authors: Bojiang Chen, Xuping Chen, Ping Zhou, Lan Yang, Jing Ren, Xiaodong Yang and Weimin Li

    Citation: Respiratory Research 2019 20:262

    Content type: Research

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  21. Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such,...

    Authors: Kalina R. Atanasova and Leah R. Reznikov

    Citation: Respiratory Research 2019 20:261

    Content type: Review

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  22. Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on long-t...

    Authors: Katharina Ruf, Wolfgang Thomas, Maximilian Brunner, Christian P. Speer and Helge Hebestreit

    Citation: Respiratory Research 2019 20:260

    Content type: Research

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  23. Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to...

    Authors: Rebecca L. Vanders, Alan Hsu, Peter G. Gibson, Vanessa E. Murphy and Peter A. B. Wark

    Citation: Respiratory Research 2019 20:259

    Content type: Research

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  24. Prognostic biomarkers in asthma are needed. The biomarker soluble urokinase plasminogen activator receptor (suPAR) has been associated with asthma control and with prognosis in acutely admitted medical patient...

    Authors: K. E. J. Håkansson, Line J. H. Rasmussen, Nina S. Godtfredsen, Oliver D. Tupper, Jesper Eugen-Olsen, Thomas Kallemose, Ove Andersen and Charlotte Suppli Ulrik

    Citation: Respiratory Research 2019 20:258

    Content type: Research

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  25. Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).

    Authors: Sarah Marietta von Siemens, Robert Perneczky, Claus F. Vogelmeier, Jürgen Behr, Diego Kauffmann-Guerrero, Peter Alter, Franziska C. Trudzinski, Robert Bals, Christian Grohé, Sandra Söhler, Benjamin Waschki, Johanna I. Lutter, Tobias Welte, Rudolf A. Jörres and Kathrin Kahnert

    Citation: Respiratory Research 2019 20:257

    Content type: Research

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  26. Distinct clinical presentations of interstitial lung disease (ILD) with the myositis-specific antibodies, including anti-synthetase antibodies, are well-recognized. However, the association between ILD and the...

    Authors: A. Sclafani, K. M. D’Silva, B. P. Little, E. M. Miloslavsky, J. J. Locascio, A. Sharma and S. B. Montesi

    Citation: Respiratory Research 2019 20:256

    Content type: Research

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  27. Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification and disordered angiogenesis. Stromal derived factor-1 (SDF-1) is a chemokine which modulates cell migration, proliferation, and angi...

    Authors: Kasonya Guerra, Carleene Bryan, Frederick Dapaah-Siakwan, Ibrahim Sammour, Shelly Drummond, Ronald Zambrano, Pingping Chen, Jian Huang, Mayank Sharma, Sebastian Shrager, Merline Benny, Shu Wu and Karen C. Young

    Citation: Respiratory Research 2019 20:255

    Content type: Research

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  28. Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix compo...

    Authors: J. Michael Wells, Dongqi Xing, Liliana Viera, Robert M. Burkes, Yixin Wu, Surya P. Bhatt, Mark T. Dransfield, David J. Couper, Wanda O’Neal, Eric A. Hoffman, Amit Gaggar, Igor Barjaktarevic, Jeffrey L. Curtis, Wassim W. Labaki, Mei Lan K. Han, Christine M. Freeman…

    Citation: Respiratory Research 2019 20:254

    Content type: Research

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  29. Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this ...

    Authors: David Pritchard, Ayodeji Adegunsoye, Elyse Lafond, Janelle Vu Pugashetti, Ryan DiGeronimo, Noelle Boctor, Nandini Sarma, Isabella Pan, Mary Strek, Michael Kadoch, Jonathan H. Chung and Justin M. Oldham

    Citation: Respiratory Research 2019 20:253

    Content type: Research

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  30. Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways...

    Authors: Amika K. Sood, Allison J. Burbank, Michael Lawson, Haibo Zhou, Heather B. Wells, David B. Peden and Michelle L. Hernandez

    Citation: Respiratory Research 2019 20:252

    Content type: Letter to the Editor

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  31. Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contr...

    Authors: Miyoko Tatsuta, Keiko Kan-o, Yumiko Ishii, Norio Yamamoto, Tomohiro Ogawa, Satoru Fukuyama, Aimi Ogawa, Akitaka Fujita, Yoichi Nakanishi and Koichiro Matsumoto

    Citation: Respiratory Research 2019 20:251

    Content type: Research

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  32. Balloon pulmonary angioplasty (BPA) has been demonstrated to improve cardiac function and exercise capacity in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but its instant im...

    Authors: Qi Jin, Qin Luo, Tao Yang, Qixian Zeng, Xue Yu, Lu Yan, Yi Zhang, Qing Zhao, Xiuping Ma, Chenhong An, Changming Xiong, Zhihui Zhao and Zhihong Liu

    Citation: Respiratory Research 2019 20:250

    Content type: Research

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  33. Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and scarring. The pathological mechanism causing pulmonary fibrosis remains unknown. Emerging evidence suggests prominent r...

    Authors: Chuyi Zhang, Xiaoping Zhu, Yifei Hua, Qian Zhao, Kaijing Wang, Lixiao Zhen, Guangxue Wang, Jinhui Lü, An Luo, William C. Cho, Xin Lin and Zuoren Yu

    Citation: Respiratory Research 2019 20:249

    Content type: Research

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  34. Small cell lung cancer (SCLC) is a highly aggressive lung cancer subtype with poor survival and limited treatment options. Sequencing results have revealed gene mutations associated with SCLC, however, the cor...

    Authors: Mengting Zhou, Jun Fan, Zhenyu Li, Pindong Li, Yajie Sun, Yuhui Yang, Xiaoshu Zhou, Jing Wang, Ye Wang, Huiwei Qi, Weijing Cai, Xiaofang Dai and Fred R. Hirsch

    Citation: Respiratory Research 2019 20:248

    Content type: Research

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  35. Chemical pleurodesis is a therapeutic procedure applied to create the symphysis between the parietal and visceral pleura by intrapleural administration of various chemical agents (e.g. talk, tetracycline, iodo...

    Authors: Michal Mierzejewski, Piotr Korczynski, Rafal Krenke and Julius P. Janssen

    Citation: Respiratory Research 2019 20:247

    Content type: Review

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  36. The lung microbiome maintains the homeostasis of the immune system within the lungs. In acute respiratory distress syndrome (ARDS), the lung microbiome is enriched with gut-derived bacteria; however, the speci...

    Authors: Michihito Kyo, Keisuke Nishioka, Takaaki Nakaya, Yoshiko Kida, Yuko Tanabe, Shinichiro Ohshimo and Nobuaki Shime

    Citation: Respiratory Research 2019 20:246

    Content type: Research

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  37. In acute respiratory distress syndrome (ARDS) damaged alveolar epithelium, leakage of plasma proteins into the alveolar space and inactivation of pulmonary surfactant lead to respiratory dysfunction. Lung func...

    Authors: J. Zebialowicz Ahlström, F. Massaro, P. Mikolka, R. Feinstein, G. Perchiazzi, O. Basabe-Burgos, T. Curstedt, A. Larsson, J. Johansson and A. Rising

    Citation: Respiratory Research 2019 20:245

    Content type: Research

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  38. T follicular helper (Tfh) cells have been identified as a new category of helper T cells, which express CXCR5 on their surface and induce the production of antigen-specific antibodies. Many investigations have...

    Authors: Yuichiro Asai, Hirofumi Chiba, Hirotaka Nishikiori, Ryuta Kamekura, Hayato Yabe, Shun Kondo, Satsuki Miyajima, Katsunori Shigehara, Shingo Ichimiya and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:244

    Content type: Research

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  39. Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age....

    Authors: Xizi Du, Lin Yuan, Mengping Wu, Meichao Men, Ruoxi He, Leyuan Wang, Shuangyan Wu, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chengping Hu, Ling Qin and Chi Liu

    Citation: Respiratory Research 2019 20:243

    Content type: Research

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  40. Guidelines recommend that treatment with a long-acting β2 agonist (LABA), a long-acting muscarinic antagonist (LAMA), and inhaled corticosteroids (ICS), i.e. triple therapy, is reserved for a select group of symp...

    Authors: Sue Langham, Jen Lewis, Nick Pooley, Nina Embleton, Julia Langham, MeiLan K. Han and James D. Chalmers

    Citation: Respiratory Research 2019 20:242

    Content type: Review

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  41. Revefenacin is a long-acting muscarinic antagonist that was recently approved for the nebulized treatment of chronic obstructive pulmonary disease (COPD). Although shorter duration studies have documented the ...

    Authors: James F. Donohue, Edward Kerwin, Sanjay Sethi, Brett Haumann, Srikanth Pendyala, Lorna Dean, Chris N. Barnes, Edmund J. Moran and Glenn Crater

    Citation: Respiratory Research 2019 20:241

    Content type: Research

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  42. Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on...

    Authors: Jonathan M. Carnino, Heedoo Lee and Yang Jin

    Citation: Respiratory Research 2019 20:240

    Content type: Review

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  43. Inflammation plays an important role in the pathogenesis of many lung diseases. Preclinical studies suggest that mesenchymal stromal cell (MSC) conditioned media (CdM) can attenuate inflammation. Our aim was t...

    Authors: Chimobi Emukah, Evan Dittmar, Rija Naqvi, John Martinez, Alexis Corral, Axel Moreira and Alvaro Moreira

    Citation: Respiratory Research 2019 20:239

    Content type: Review

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  44. Prospective evidence is lacking regarding incremental benefits of long-acting dual- versus mono-bronchodilation in improving symptoms and preventing short-term disease worsening/treatment failure in low exacer...

    Authors: François Maltais, Leif Bjermer, Edward M. Kerwin, Paul W. Jones, Michael L. Watkins, Lee Tombs, Ian P. Naya, Isabelle H. Boucot, David A. Lipson, Chris Compton, Mitra Vahdati-Bolouri and Claus F. Vogelmeier

    Citation: Respiratory Research 2019 20:238

    Content type: Research

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  45. In the BACE trial, a 3-month (3 m) intervention with azithromycin, initiated at the onset of an infectious COPD exacerbation requiring hospitalization, decreased the rate of a first treatment failure (TF); the...

    Authors: Kristina Vermeersch, Ann Belmans, Kris Bogaerts, Iwein Gyselinck, Nina Cardinaels, Maria Gabrovska, Joseph Aumann, Ingel K. Demedts, Jean-Louis Corhay, Eric Marchand, Hans Slabbynck, Christel Haenebalcke, Stefanie Vermeersch, Geert M. Verleden, Thierry Troosters, Vincent Ninane…

    Citation: Respiratory Research 2019 20:237

    Content type: Research

    Published on:

  46. There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate t...

    Authors: Yilan Sun, Stephen Milne, Jen Erh Jaw, Chen Xi Yang, Feng Xu, Xuan Li, Ma’en Obeidat and Don D. Sin

    Citation: Respiratory Research 2019 20:236

    Content type: Research

    Published on:

  47. As a consequence of the increased mortality observed in the SERVE-HF study, many questions concerning the safety and rational use of ASV in other indications emerged. The aim of this study was to describe the ...

    Authors: Dany Jaffuel, Carole Philippe, Claudio Rabec, Jean-Pierre Mallet, Marjolaine Georges, Stefania Redolfi, Alain Palot, Carey M. Suehs, Erika Nogue, Nicolas Molinari and Arnaud Bourdin

    Citation: Respiratory Research 2019 20:235

    Content type: Research

    Published on:

  48. Asthma is a heterogenous disease characterized by chronic inflammation and airway remodeling. An increase in the severity of airway remodeling is associated with a more severe form of asthma. There is increasi...

    Authors: Alexandre Haddad, Mellissa Gaudet, Maria Plesa, Zoulfia Allakhverdi, Andrea K. Mogas, Severine Audusseau, Carolyn J. Baglole, David H. Eidelman, Ronald Olivenstein, Mara S. Ludwig and Qutayba Hamid

    Citation: Respiratory Research 2019 20:234

    Content type: Research

    Published on:

  49. Accumulating evidence has shown the important roles of long non-coding RNAs (lncRNAs) in acute lung injury (ALI). This study aimed to investigate the potential role of lncRNA small nucleolar RNA host gene 14 (...

    Authors: Jinyuan Zhu, Jijia Bai, Shaojin Wang and Hui Dong

    Citation: Respiratory Research 2019 20:233

    Content type: Research

    Published on:

  50. Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell...

    Authors: Peter Heukels, Jennifer A. C. van Hulst, Menno van Nimwegen, Carian E. Boorsma, Barbro N. Melgert, Jan H. von der Thusen, Bernt van den Blink, Rogier A. S. Hoek, Jelle R. Miedema, Stefan F. H. Neys, Odilia B. J. Corneth, Rudi W. Hendriks, Marlies S. Wijsenbeek and Mirjam Kool

    Citation: Respiratory Research 2019 20:232

    Content type: Research

    Published on:

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