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  1. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce excessive extracellular matrix accumula...

    Authors: Arnoldo Aquino-Gálvez, Georgina González-Ávila, Laura Lorena Jiménez-Sánchez, Héctor Aquiles Maldonado-Martínez, José Cisneros, Fernanda Toscano-Marquez, Manuel Castillejos-López, Luz María Torres-Espíndola, Rafael Velázquez-Cruz, Víctor Hugo Olivera Rodríguez, Edgar Flores-Soto, Héctor Solís-Chagoyán, Carlos Cabello, Joaquín Zúñiga and Yair Romero

    Citation: Respiratory Research 2019 20:130

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  2. Content type: Research

    Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its ant...

    Authors: Ari Jon Arason, Jon Petur Joelsson, Bryndis Valdimarsdottir, Snaevar Sigurdsson, Alexander Gudjonsson, Skarphedinn Halldorsson, Freyr Johannsson, Ottar Rolfsson, Fredrik Lehmann, Saevar Ingthorsson, Paulina Cherek, Gudmundur H. Gudmundsson, Fridrik R. Gardarsson, Clive P. Page, Olafur Baldursson, Thorarinn Gudjonsson…

    Citation: Respiratory Research 2019 20:129

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  3. Content type: Research

    Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis...

    Authors: Michael E. O’Brien, Divay Chandra, Robert C. Wilson, Chad M. Karoleski, Carl R. Fuhrman, Joseph K. Leader, Jiantao Pu, Yingze Zhang, Alison Morris, Seyed Nouraie, Jessica Bon, Zsolt Urban and Frank C. Sciurba

    Citation: Respiratory Research 2019 20:128

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  4. Content type: Research

    Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF...

    Authors: Estrella Fernández-Fabrellas, María Molina-Molina, Joan B. Soriano, José Antonio Rodríguez Portal, Julio Ancochea, Claudia Valenzuela and Antoni Xaubet

    Citation: Respiratory Research 2019 20:127

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  5. Content type: Research

    Viral respiratory infection (VRI) is a common contraindication to elective surgery. Asymptomatic shedding among pediatric surgery patients (PSPs) could potentially lead to progression of symptomatic diseases a...

    Authors: Dan Zhang, Xiuyu Lou, Hao Yan, Junhang Pan, Haiyan Mao, Hongfeng Tang, Yan Shu, Yun Zhao, Lei Liu, Junping Li, Dong Chen, Yanjun Zhang and Xuejun Ma

    Citation: Respiratory Research 2019 20:126

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  6. Content type: Research

    Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possib...

    Authors: Marcell Szily, Adam D. Tarnoki, David L. Tarnoki, Daniel T. Kovacs, Bianka Forgo, Jooyeon Lee, Eunae Kim, Joohon Sung, Laszlo Kunos, Martina Meszaros, Veronika Muller and Andras Bikov

    Citation: Respiratory Research 2019 20:125

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  7. Content type: Research

    Allergic mechanisms related to environmental and occupational exposure have been suggested to contribute to the development of chronic obstructive pulmonary disease (COPD).

    Authors: Matthieu Veil-Picard, Thibaud Soumagne, Rechana Vongthilath, Isabella Annesi-Maesano, Alicia Guillien, Lucie Laurent, Pascal Andujar, Nicolas Roche, Stephane Jouneau, Benoit Cypriani, Jean-Jacques Laplante, Bruno Degano and Jean-Charles Dalphin

    Citation: Respiratory Research 2019 20:124

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  8. Content type: Research

    Right ventricular (RV) angiogenesis has been associated with adaptive myocardial remodeling in pulmonary hypertension (PH), though molecular regulators are poorly defined. Endothelial cell VEGFR-2 is considere...

    Authors: Grace L. Peloquin, Laura Johnston, Mahendra Damarla, Rachel L. Damico, Paul M. Hassoun and Todd M. Kolb

    Citation: Respiratory Research 2019 20:123

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  9. Content type: Research

    Previous studies have found associations between asthma morbidity and air pollution especially in young population, (PLoS One 12:e0180522, 2017; Can J Public Health 103:4-8, 2012; Environ Health Perspect 118:4...

    Authors: Feifei Liu, Fangfang Qu, Huiran Zhang, Lingshan Chao, Rongqin Li, Fengxue Yu, Jitao Guan and Xixin Yan

    Citation: Respiratory Research 2019 20:122

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  10. Content type: Research

    Abnormal sympathetic hyperactivity has been shown to lead to pulmonary arterial hypertension (PAH) deterioration. The purpose of this study was to examine whether the transection of the cervical sympathetic tr...

    Authors: Yongpeng Zhao, Rui Xiang, Xin Peng, Qian Dong, Dan Li, Guiquan Yu, Lei Xiao, Shu Qin and Wei Huang

    Citation: Respiratory Research 2019 20:121

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  11. Content type: Research

    A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease ...

    Authors: Junling Zhao, Miao Li, Zhihua Wang, Jinkun Chen, Jianping Zhao, Yongjian Xu, Xiang Wei, Jianmao Wang and Jungang Xie

    Citation: Respiratory Research 2019 20:120

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  12. Content type: Research

    Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1...

    Authors: Jin Jin, Shinsaku Togo, Kotaro Kadoya, Miniwan Tulafu, Yukiko Namba, Moe Iwai, Junko Watanabe, Kumi Nagahama, Takahiro Okabe, Moulid Hidayat, Yuzo Kodama, Hideya Kitamura, Takashi Ogura, Norikazu Kitamura, Kazuho Ikeo, Shinichi Sasaki…

    Citation: Respiratory Research 2019 20:119

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  13. Content type: Research

    The mechanisms of lung injury in acute respiratory distress syndrome (ARDS) are not well understood.Piezo1 was recently identified as a mechanotransduction protein. The present study found the expression of Pi...

    Authors: Guo-Peng Liang, Jing Xu, Li-li Cao, Yi-Hua Zeng, Bai-Xu Chen, Jing Yang, Zhong-Wei Zhang and Yan Kang

    Citation: Respiratory Research 2019 20:118

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  14. Content type: Research

    Connective tissue disease associated with interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD) alone have same pathological and imaging backgrounds. However, the differences between lung can...

    Authors: Won-Il Choi, Dong Yoon Lee, Hyun-Gi Choi and Choong Won Lee

    Citation: Respiratory Research 2019 20:117

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  15. Content type: Research

    Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung up...

    Authors: Monica P. Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M. D’Armiento and Lynne L. Johnson

    Citation: Respiratory Research 2019 20:116

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  16. Content type: Study protocol

    Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...

    Authors: James E. Gern, Daniel J. Jackson, Robert F. Lemanske Jr, Christine M. Seroogy, Umberto Tachinardi, Mark Craven, Stephen Y. Hwang, Carol M. Hamilton, Wayne Huggins, George T. O’Connor, Diane R. Gold, Rachel Miller, Meyer Kattan, Christine C. Johnson, Dennis Ownby, Edward M. Zoratti…

    Citation: Respiratory Research 2019 20:115

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  17. Content type: Research

    Chronic obstructive pulmonary disease (COPD) frequent exacerbators (FE) suffer increased morbidity and mortality compared to infrequent exacerbators (IE). The association between the oral and sputum microbiota...

    Authors: Alexa A. Pragman, Katherine A. Knutson, Trevor J. Gould, Richard E. Isaacson, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2019 20:114

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  18. Content type: Research

    The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly und...

    Authors: Li Long, Hongmei Yao, Jing Tian, Wei Luo, Xinxin Yu, Fang Yi, Qiaoli Chen, Jiaxing Xie, Nanshan Zhong, Kian Fan Chung and Kefang Lai

    Citation: Respiratory Research 2019 20:112

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  19. Content type: Research

    Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PA...

    Authors: Annette D. Rieg, Nina A. Bünting, Christian Cranen, Said Suleiman, Jan W. Spillner, Heike Schnöring, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Paul W. Manley, Gereon Schälte, Rolf Rossaint, Stefan Uhlig and Christian Martin

    Citation: Respiratory Research 2019 20:111

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  20. Content type: Research

    Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model ...

    Authors: Fajer Al-Shamlan and Ahmed Z. El-Hashim

    Citation: Respiratory Research 2019 20:110

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  21. Content type: Research

    The differential diagnosis of paediatric respiratory conditions is difficult and suboptimal. Existing diagnostic algorithms are associated with significant error rates, resulting in misdiagnoses, inappropriate...

    Authors: Paul Porter, Udantha Abeyratne, Vinayak Swarnkar, Jamie Tan, Ti-wan Ng, Joanna M. Brisbane, Deirdre Speldewinde, Jennifer Choveaux, Roneel Sharan, Keegan Kosasih and Phillip Della

    Citation: Respiratory Research 2019 20:81

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  22. Content type: Research

    Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously ...

    Authors: Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch and Fumito Ichinose

    Citation: Respiratory Research 2019 20:109

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  23. Content type: Research

    Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and ...

    Authors: Xiao-feng Xiong, Min Zhu, Hong-xia Wu, Li-li Fan and De-yun Cheng

    Citation: Respiratory Research 2019 20:108

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  24. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships...

    Authors: Laurie Snyder, Megan L. Neely, Anne S. Hellkamp, Emily O’Brien, Joao de Andrade, Craig S. Conoscenti, Thomas Leonard, Shaun Bender, Mridu Gulati, Daniel A. Culver, Robert J. Kaner, Scott Palmer and Hyun Joo Kim

    Citation: Respiratory Research 2019 20:105

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  25. Content type: Research

    Tumor chemo-resistance is a hallmark of malignant tumors as well as the major cause of poor survival rates in lung cancer. Transmembrane-4 L-six family member-1 (TM4SF1), an antigen that serves as an oncogene, ma...

    Authors: Lin Ye, Chunyun Pu, Jun Tang, Yan Wang, Can Wang, Zhu Qiu, Tingxiu Xiang, Yunmei Zhang and Weiyan Peng

    Citation: Respiratory Research 2019 20:106

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  26. Content type: Research

    To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in ch...

    Authors: Paola Rogliani, Maria Gabriella Matera, Clive Page, Ermanno Puxeddu, Mario Cazzola and Luigino Calzetta

    Citation: Respiratory Research 2019 20:104

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  27. Content type: Research

    Surveys and retrospective studies of patients with idiopathic pulmonary fibrosis (IPF) have shown a significant diagnostic delay. However, the causes and risk factors for this delay are not known.

    Authors: Nils Hoyer, Thomas Skovhus Prior, Elisabeth Bendstrup, Torgny Wilcke and Saher Burhan Shaker

    Citation: Respiratory Research 2019 20:103

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  28. Content type: Research

    Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypot...

    Authors: Petra Um-Bergström, Jenny Hallberg, Melvin Pourbazargan, Eva Berggren-Broström, Giovanni Ferrara, Maria J. Eriksson, Sven Nyrén, Jing Gao, Gunnar Lilja, Anders Lindén, Åsa M. Wheelock, Erik Melén and C. Magnus Sköld

    Citation: Respiratory Research 2019 20:102

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  29. Content type: Research

    The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry,...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, Ronald A. Karwoski, Cosimo Nardi, Riccardo Inchingolo, Anna R. Larici, Gianna Camiciottoli, Federico Lavorini, Stefano Colagrande, Vito Brusasco and Massimo Pistolesi

    Citation: Respiratory Research 2019 20:101

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  30. Content type: Research

    Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calc...

    Authors: Merry-Lynn N. McDonald, Emiel F. M. Wouters, Erica Rutten, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Marcas Bamman, Bartolome Celli, Alvar Agusti, Ruth Tal-Singer, Craig P. Hersh, Mark Dransfield and Edwin K. Silverman

    Citation: Respiratory Research 2019 20:100

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  31. Content type: Research

    Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin serum levels. Interestingly, patients with Chronic Obstr...

    Authors: Cédric Vonarburg, Marius Loetscher, Martin O. Spycher, Alain Kropf, Marlies Illi, Sharon Salmon, Sean Roberts, Karin Steinfuehrer, Ian Campbell, Sandra Koernig, Joseph Bain, Monika Edler, Ulrich Baumann, Sylvia Miescher, Dennis W. Metzger, Alexander Schaub…

    Citation: Respiratory Research 2019 20:99

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  32. Content type: Research

    Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and ...

    Authors: Wilfried Karmaus, Nandini Mukherjee, Vimala Devi Janjanam, Su Chen, Hongmei Zhang, Graham Roberts, Ramesh J. Kurukulaaratchy and Hasan Arshad

    Citation: Respiratory Research 2019 20:98

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  33. Content type: Research

    We recently showed that intravenous sodium nitroprusside treatment (SNP) could relieve the pulmonary vasospasm of pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions in a rabbit massive pulmona...

    Authors: Yuting Wang, Delong Yu, Yijun Yu, Wusong Zou, Xiaohui Zeng, Liqun Hu and Ye Gu

    Citation: Respiratory Research 2019 20:97

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  34. Content type: Research

    Nitric oxide is a mediator of potential importance in numerous physiological and inflammatory processes in the lung. Aminoguanidine (AG) has been shown to have anti-inflammation and radical scavenging properti...

    Authors: Saeideh Saadat, Farimah Beheshti, Vahid Reza Askari, Mahmoud Hosseini, Nema Mohamadian Roshan and Mohammad Hossein Boskabady

    Citation: Respiratory Research 2019 20:96

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  35. Content type: Research

    Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflam...

    Authors: Lei Liu, Xin Zhang, Ying Liu, Li Zhang, Jing Zheng, Ji Wang, Philip M. Hansbro, Lei Wang, Gang Wang and Alan Chen-Yu Hsu

    Citation: Respiratory Research 2019 20:95

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  36. Content type: Research

    Tobacco smoke exposure impairs the lung’s innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has antimicrobial activi...

    Authors: Patrick J. Moore, Juliana Sesma, Neil E. Alexis and Robert Tarran

    Citation: Respiratory Research 2019 20:94

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  37. Content type: Research

    One of the known weaknesses of spirometry is its dependence on patients’ cooperation, which can only partially be alleviated by educational efforts. Therefore, procedures less dependent on cooperation might be...

    Authors: Christina Kellerer, Neele Jankrift, Rudolf A. Jörres, Klaus Klütsch, Stefan Wagenpfeil, Klaus Linde and Antonius Schneider

    Citation: Respiratory Research 2019 20:92

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  38. Content type: Research

    Wheezing among children below the age of six (pre-schoolers) is common and often triggered by environmental factors. Moreover, evidence on which to base recommendations for its management is limited, resulting...

    Authors: Sonia Trabelsi, Lidia Casas, Benoit Nemery, Tim S. Nawrot and Isabelle Thomas

    Citation: Respiratory Research 2019 20:90

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  39. Content type: Research

    The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Init...

    Authors: Florin Mihaltan, Yochai Adir, Adam Antczak, Konstantinos Porpodis, Vesna Radulovic, Nuno Pires, Geeuwke Jan de Vries, Andreas Horner, Samuel De Bontridder, Yunqin Chen, Anat Shavit, Silviu Alecu and Lukasz Adamek

    Citation: Respiratory Research 2019 20:89

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  40. Content type: Research

    While additional oxygen supply is often required for the survival of very premature infants in intensive care, this also brings an increasing risk of progressive lung diseases and poor long-term lung outcomes....

    Authors: Stefanie Endesfelder, Evelyn Strauß, Till Scheuer, Thomas Schmitz and Christoph Bührer

    Citation: Respiratory Research 2019 20:88

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  41. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechani...

    Authors: Eva Schruf, Victoria Schroeder, Christian A. Kuttruff, Sabine Weigle, Martin Krell, Maryke Benz, Tom Bretschneider, Alexander Holweg, Michael Schuler, Manfred Frick, Paul Nicklin, James P. Garnett and Mirko C. Sobotta

    Citation: Respiratory Research 2019 20:87

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  42. Content type: Research

    Platelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between p...

    Authors: Ashraf Fawzy, Julie A. Anderson, Nicholas J. Cowans, Courtney Crim, Robert Wise, Julie C. Yates and Nadia N. Hansel

    Citation: Respiratory Research 2019 20:86

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  43. Content type: Research

    Although bronchodilator inhaler therapy can improve lung function in patients with tuberculous destroyed lung (TDL), its effect on mortality has not been studied. We evaluated the effect of tiotropium inhaler ...

    Authors: Ho Cheol Kim, Tae Hoon Kim, Ye-Jee Kim, Chin Kook Rhee and Yeon-Mok Oh

    Citation: Respiratory Research 2019 20:85

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  44. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction ca...

    Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang and Qin Wang

    Citation: Respiratory Research 2019 20:84

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  45. Content type: Letter to the Editor

    An inverse relationship between oral corticosteroid (OCS) dose and peripheral blood eosinophil (PBE) count is widely recognized in patients with severe eosinophilic asthma; however, there are limited data avai...

    Authors: Charlene M. Prazma, Elisabeth H. Bel, Robert G. Price, Eric S. Bradford, Frank C. Albers and Steven W. Yancey

    Citation: Respiratory Research 2019 20:83

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  46. Content type: Research

    Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Antibiotics are losing their effectiveness due to the emerging infectious diseases, the scarcity of novel antibiotics...

    Authors: Yali Zheng, Pu Ning, Qiongzhen Luo, Yukun He, Xu Yu, Xiaohui Liu, Yusheng Chen, Xiaorong Wang, Yu Kang and Zhancheng Gao

    Citation: Respiratory Research 2019 20:82

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