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  1. Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we exami...

    Authors: Houman Goudarzi, Hirokazu Kimura, Hiroki Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Kaoruko Shimizu, Masaru Suzuki, Taku Watanabe, Eiki Kikuchi, Hiroshi Ohira, Ichizo Tsujino, Jun Sakakibara-Konishi, Naofumi Shinagawa, Noriharu Shijubo, Hirokazu Sato…
    Citation: Respiratory Research 2022 23:174
  2. Chronic obstructive pulmonary disease (COPD) is a health problem that results in death, commonly due to the development of pulmonary hypertension (PH). Here, by utilizing a mouse model of intratracheal elastas...

    Authors: Ratoe Suraya, Tatsuya Nagano, Gusty Rizky Teguh Ryanto, Wiwin Is Effendi, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Noriaki Emoto, Yoshihiro Nishimura and Kazuyuki Kobayashi
    Citation: Respiratory Research 2022 23:173
  3. Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. Discovering the potential metabolic alterations underlying the ARDS is important to identify novel therapeutic target and improve t...

    Authors: Yongqin Yan, Jianuo Chen, Qian Liang, Hong Zheng, Yiru Ye, Wengang Nan, Xi Zhang, Hongchang Gao and Yuping Li
    Citation: Respiratory Research 2022 23:172
  4. Few data exist on high flow nasal cannula (HFNC) use in patients with acute respiratory failure (ARF) admitted to general wards.

    Authors: Sebastiano Maria Colombo, Vittorio Scaravilli, Andrea Cortegiani, Nadia Corcione, Amedeo Guzzardella, Luca Baldini, Elisa Cassinotti, Ciro Canetta, Stefano Carugo, Cinzia Hu, Anna Ludovica Fracanzani, Ludovico Furlan, Maria Chiara Paleari, Alessandro Galazzi, Paola Tagliabue, Flora Peyvandi…
    Citation: Respiratory Research 2022 23:171
  5. Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD)...

    Authors: M. C. Schimmelpennink, D. B. Meek, A. D. M. Vorselaars, L. C. M. Langezaal, C. H. M. van Moorsel, J. J. van der Vis, M. Veltkamp and J. C. Grutters
    Citation: Respiratory Research 2022 23:169
  6. Studies of the respiratory tract microbiome primarily focus on airway and lung microbial diversity, but it is still unclear how these microbial communities may be affected by intubation and long periods in int...

    Authors: Erika Alejandra Cifuentes, Maria A. Sierra, Andrés Felipe Yepes, Ana Margarita Baldión, José Antonio Rojas, Carlos Arturo Álvarez-Moreno, Juan Manuel Anzola, María Mercedes Zambrano and Monica G. Huertas
    Citation: Respiratory Research 2022 23:168
  7. Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by improper biogenesis of lysosome-related organelles (LROs). Lung fibrosis is the leading cause of death among adults with HPS-...

    Authors: Jewel Imani, Steven P. M. Bodine, Anthony M. Lamattina, Diane D. Ma, Shikshya Shrestha, Dawn M. Maynard, Kevin Bishop, Arinze Nwokeji, May Christine V. Malicdan, Lauren C. Testa, Raman Sood, Benjamin Stump, Ivan O. Rosas, Mark A. Perrella, Robert Handin, Lisa R. Young…
    Citation: Respiratory Research 2022 23:167
  8. Cough strength is associated with short-term outcome in patients with scheduled extubation who successfully complete a spontaneous breathing trial (SBT). However, the long-term outcome is unclear.

    Authors: Yueling Hong, Min Deng, Wenhui Hu, Rui Zhang, Lei Jiang, Linfu Bai and Jun Duan
    Citation: Respiratory Research 2022 23:166
  9. Asthma is a major cause of morbidity and mortality in humans. The mechanisms of asthma are still not fully understood. Leukocyte-specific protein-1 (LSP-1) regulates neutrophil migration during acute lung infl...

    Authors: Nguyen Phuong Khanh Le, Amanda Florentina do Nascimento, David Schneberger, Chi Cuong Quach, Xiaobei Zhang, Gurpreet K. Aulakh, Wojciech Dawicki, Lixin Liu, John R. Gordon and Baljit Singh
    Citation: Respiratory Research 2022 23:165
  10. Rituximab (RTX) has been previously reported as directed treatment in patients with connective-tissue disease-related interstitial lung diseases (CTD-ILD). A systematic assessment of treatment effect size on p...

    Authors: Yuanchen Zhao, Yang Gao, Tananchai Petnak, Wisit Cheungpasitporn, Charat Thongprayoon, Xing Zhang and Teng Moua
    Citation: Respiratory Research 2022 23:164
  11. Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COP...

    Authors: Marta Marin-Oto, David Sanz-Rubio, Fernando Santamaría-Martos, Ivan Benitez, Ana L. Simon, Marta Forner, Pablo Cubero, Ana Gil, Manuel Sanchez-de-laTorre, Ferran Barbe and José M. Marin
    Citation: Respiratory Research 2022 23:163
  12. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but ar...

    Authors: Wanhai Qin, C. Arnold Spek, Brendon P. Scicluna, Tom van der Poll and JanWillem Duitman
    Citation: Respiratory Research 2022 23:162
  13. Recent studies have demonstrated the important role of metabolomics in the pathogenesis of asthma. However, the role of lung metabolomics in childhood persistent wheezing (PW) or wheezing recurrence remains po...

    Authors: Lingfang Liang, Minfei Hu, Yuanling Chen, Lingke Liu, Lei Wu, Chengcheng Hang, Xiaofei Luo and Xuefeng Xu
    Citation: Respiratory Research 2022 23:161
  14. Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease, and other primary lung disorders. Importantly, va...

    Authors: Jill A. Poole, Ted R. Mikuls, Geoffrey M. Thiele, Rohit Gaurav, Amy J. Nelson, Michael J. Duryee, Ananya Mitra, Carlos Hunter, Todd A. Wyatt, Bryant R. England and Dana P. Ascherman
    Citation: Respiratory Research 2022 23:160
  15. Interstitial lung abnormalities (ILA) are radiologic findings that may progress to idiopathic pulmonary fibrosis (IPF). Blood gene expression profiles can predict IPF mortality, but whether these same genes as...

    Authors: Matthew Moll, Brian D. Hobbs, Aravind Menon, Auyon J. Ghosh, Rachel K. Putman, Takuya Hino, Akinori Hata, Edwin K. Silverman, John Quackenbush, Peter J. Castaldi, Craig P. Hersh, Michael J. McGeachie, Don D. Sin, Ruth Tal-Singer, Mizuki Nishino, Hiroto Hatabu…
    Citation: Respiratory Research 2022 23:157
  16. Acute respiratory distress syndrome (ARDS) is a neutrophil-associated disease. Delayed neutrophil apoptosis and increased levels of neutrophil extracellular traps (NETs) have been described in ARDS. We aimed t...

    Authors: Chao Song, Haitao Li, Zhi Mao, Ling Peng, Ben Liu, Fengyu Lin, Yi Li, Minhui Dai, Yanhui Cui, Yuhao Zhao, Duoduo Han, Lingli Chen, Xun Huang and Pinhua Pan
    Citation: Respiratory Research 2022 23:155
  17. Chronic obstructive pulmonary disease (COPD) is one of the world’s leading causes of death and a major chronic disease, highly prevalent in the aging population exposed to tobacco smoke and airborne pollutants...

    Authors: Pengcheng Liu, Yucong Wang, Ningning Zhang, Xiaomin Zhao, Renming Li, Yu Wang, Chen Chen, Dandan Wang, Xiaoming Zhang, Liang Chen and Dahai Zhao
    Citation: Respiratory Research 2022 23:154
  18. Service member exposure to explosive blast overpressure waves is common with considerable attention to traumatic brain injury (TBI) and neuropsychological sequalae. Less is known about the impacts on the respi...

    Authors: Jennifer H. Therkorn, Sean Hu, Anays M. Sotolongo, Israel C. Christie, Tianshi David Wu, William W. Van Doren, Venkata Siva Sai Sujith Sajja, Nisha Jani, Jacquelyn C. Klein-Adams, Drew A. Helmer and Michael J. Falvo
    Citation: Respiratory Research 2022 23:153
  19. Currently, strategies for improving alpha1 antitrypsin deficiency (AATD) diagnosis are needed. Here we report the performance of a multinational multiplex-based genotyping test on dried blood spots and buccal ...

    Authors: José Luis Lopez-Campos, Lourdes Osaba, Karen Czischke, José R. Jardim, Mariano Fernandez Acquier, Abraham Ali, Hakan Günen, Noelia Rapun, Estrella Drobnic and Marc Miravitlles
    Citation: Respiratory Research 2022 23:152
  20. Oxidative stress plays a key role in the pathogenesis of respiratory diseases; however, studies on antioxidant vitamins and respiratory outcomes have been conflicting. We evaluated whether lower serum levels o...

    Authors: Paivi M. Salo, Angelico Mendy, Jesse Wilkerson, Samantha A. Molsberry, Lydia Feinstein, Stephanie J. London, Michael B. Fessler, Peter S. Thorne and Darryl C. Zeldin
    Citation: Respiratory Research 2022 23:150
  21. Dehydroepiandrosterone (DHEA) is a precursor sex hormone with antifibrotic properties. The aims of this study were to investigate antifibrotic mechanisms of DHEA, and to determine the relationship between DHEA...

    Authors: Sabina A. Guler, Carlos Machahua, Thomas K. Geiser, Gregor Kocher, Thomas M. Marti, Benjamin Tan, Verdiana Trappetti, Christopher J. Ryerson and Manuela Funke-Chambour
    Citation: Respiratory Research 2022 23:149
  22. Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pr...

    Authors: Jonathan Keow, Matthew J. Cecchini, Nathashi Jayawardena, Maurizio Zompatori, Mariamma G. Joseph and Marco Mura
    Citation: Respiratory Research 2022 23:147
  23. Musculoskeletal pain is more common in individuals with chronic respiratory diseases than the aged-matched general population. This investigation aimed to understand the prevalence and impact of hip and knee p...

    Authors: Samuel Briggs-Price, Enya Daynes, Emma Chaplin, Sarah Ward, Linzy Houchen-Wolloff and Sally J. Singh
    Citation: Respiratory Research 2022 23:146
  24. Dexamethasone improves clinical outcomes in COVID-19 patients requiring supplementary oxygen. We investigated possible mechanisms of action by comparing sixteen plasma host response biomarkers in general ward ...

    Authors: Justin de Brabander, Erik H. A. Michels, Christine C. A. van Linge, Osoul Chouchane, Renée A. Douma, Tom D. Y. Reijnders, Alex R. Schuurman, Tjitske S. R. van Engelen, W. Joost Wiersinga and Tom van der Poll
    Citation: Respiratory Research 2022 23:145
  25. Flexible bronchoscopy is widely used to diagnose and treat various respiratory diseases. However, caution is warranted for post-bronchoscopy adverse events. Although desaturation frequently occurs during bronc...

    Authors: So Yeon Kim, Hyo Jin Lee, Jung Kyu Lee, Tae Yeon Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung and Hyun Woo Lee
    Citation: Respiratory Research 2022 23:144
  26. Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease (ILD) featuring dense fibrosis of the visceral pleura and subpleural parenchyma, mostly in the upper lobes. PPFE can present in other...

    Authors: Jieun Kang, Woo Jung Seo, Eun Young Lee, Sung Hae Chang, Jooae Choe, Seokchan Hong and Jin Woo Song
    Citation: Respiratory Research 2022 23:143
  27. The assessment of lung physiology via pulmonary function tests (PFTs) is essential for patients with idiopathic pulmonary fibrosis (IPF). However, PFTs require active participation, which can be challenging fo...

    Authors: Yuko Tanaka, Yuzo Suzuki, Hirotsugu Hasegawa, Koshi Yokomura, Atsuki Fukada, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui and Takafumi Suda
    Citation: Respiratory Research 2022 23:142
  28. Immunoglobulin G (IgG) deficiency increases the risk of acute exacerbations and mortality in chronic obstructive pulmonary disease (COPD). However, the impact of IgG subclass deficiency on mortality in COPD is...

    Authors: Hyun Lee, Cara Kovacs, Andre Mattman, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Janice M. Leung and Don D. Sin
    Citation: Respiratory Research 2022 23:141
  29. The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry i...

    Authors: Tatyana Sarycheva, Nadezda Capkova, Andrzej Pająk, Sofia Malyutina, Galina Simonova, Abdonas Tamosiunas, Martin Bobák and Hynek Pikhart
    Citation: Respiratory Research 2022 23:140
  30. Pirfenidone slows down disease progression in idiopathic pulmonary fibrosis (IPF). Recent studies suggest a treatment effect in progressive pulmonary fibrosis other than IPF. However, the safety and effectiven...

    Authors: Jelle R. Miedema, Catharina C. Moor, Marcel Veltkamp, Sara Baart, Natascha S. L. Lie, Jan C. Grutters, Marlies S. Wijsenbeek and Rémy L. M. Mostard
    Citation: Respiratory Research 2022 23:139
  31. Study of pulmonary arterial hypertension (PAH) in claims-based (CB) cohorts may facilitate understanding of disease epidemiology, however previous CB algorithms to identify PAH have had limited test characteri...

    Authors: Kyle P. Schuler, Anna R. Hemnes, Jeffrey Annis, Eric Farber-Eger, Brandon D. Lowery, Stephen J. Halliday and Evan L. Brittain
    Citation: Respiratory Research 2022 23:138
  32. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and the immune inflammatory response is thought to play an important role in pathogenesis. However, the immunophenotype of patients with...

    Authors: Xiao-feng Xiong, Min Zhu, Hong-xia Wu, Li-li Fan and De-yun Cheng
    Citation: Respiratory Research 2022 23:137
  33. Pulmonary hypertension is a common and serious complication of chronic obstructive pulmonary disease (COPD). Studies suggest that cigarette smoke can initiate pulmonary vascular remodelling by stimulating cell...

    Authors: Abdullah A. Alqarni, Oliver J. Brand, Alice Pasini, Mushabbab Alahmari, Abdulrhman Alghamdi and Linhua Pang
    Citation: Respiratory Research 2022 23:136
  34. Patients with idiopathic pulmonary fibrosis (IPF) frequently have multiple comorbidities, which may influence survival but go under-recognised in clinical practice. We therefore report comorbidity, antifibroti...

    Authors: Dragana M. Jovanovic, Martina Šterclová, Nesrin Mogulkoc, Katarzyna Lewandowska, Veronika Müller, Marta Hájková, Michael Studnicka, Jasna Tekavec-Trkanjec, Simona Littnerová and Martina Vašáková
    Citation: Respiratory Research 2022 23:135
  35. Distinguishing tuberculous pleural effusion (TPE) from non-tuberculosis (TB) benign pleural effusion (BPE) remains to be a challenge in clinical practice. The aim of the present study was to develop and valida...

    Authors: Yanqing Liu, Zhigang Liang, Songbo Yuan, Shanshan Wang, Fei Guo, Weidong Peng, Jing Yang and Aihua Wu
    Citation: Respiratory Research 2022 23:134
  36. Considering the considerable prevalence of allergic disease in the general population, an urgent need exists for inactivated SARS-CoV-2 vaccines that can be safely administered to those subjects.

    Authors: Chao Cao, Feng Qiu, Chengcheng Lou, Lingling Fang, Fang Liu, Jingjing Zhong, Weijie Sun, Weiping Ding, Xiaopin Yu, Qinhong Xu, Ran Wang, Liemin Ruan and Qifa Song
    Citation: Respiratory Research 2022 23:133
  37. Timely identification of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement status in patients with non-small cell lung cancer (NSCLC) is essential for tyrosine...

    Authors: Xueyun Tan, Yuan Li, Sufei Wang, Hui Xia, Rui Meng, Juanjuan Xu, Yanran Duan, Yan Li, Guanghai Yang, Yanling Ma and Yang Jin
    Citation: Respiratory Research 2022 23:132
  38. Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is incre...

    Authors: Mark D. Ihrie, Victoria L. McQuade, Jack T. Womble, Akhil Hegde, Matthew S. McCravy, Cyrus Victor G. Lacuesta, Robert M. Tighe, Loretta G. Que, Julia K. L. Walker and Jennifer L. Ingram
    Citation: Respiratory Research 2022 23:131
  39. Recombinant human pentraxin-2 (rhPTX-2) significantly decreased decline in percent predicted forced vital capacity (FVC) and stabilized 6-min walk distance (6MWD) in patients with idiopathic pulmonary fibrosis...

    Authors: Ganesh Raghu, Mark J. Hamblin, A. Whitney Brown, Jeffrey A. Golden, Lawrence A. Ho, Marlies S. Wijsenbeek, Martina Vasakova, Alberto Pesci, Danielle E. Antin-Ozerkis, Keith C. Meyer, Michael Kreuter, Tracy Burgess, Nikhil Kamath, Francis Donaldson and Luca Richeldi
    Citation: Respiratory Research 2022 23:129
  40. Pulmonary fibrosis is a progressive and usually lethal pulmonary disease. Despite considerable research efforts, no effective therapeutic strategy for pulmonary fibrosis has been developed. NecroX-5 has been r...

    Authors: Li Min, Zhang Shu-Li, Yuan Feng, Hu Han, Li Shao-Jun, Tong Sheng-Xiong, Tian Jia-Yu, Fang Xiang-Zhi and Feng Dan
    Citation: Respiratory Research 2022 23:128
  41. Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways. Mucosal-associated invariant T (MAIT) cells are unconventiona...

    Authors: Terezia Pincikova, Tiphaine Parrot, Lena Hjelte, Marieann Högman, Karin Lisspers, Björn Ställberg, Christer Janson, Andrei Malinovschi and Johan K. Sandberg
    Citation: Respiratory Research 2022 23:127
  42. Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve...

    Authors: Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu and Rodney D. Britt Jr
    Citation: Respiratory Research 2022 23:126
  43. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung condition. Currently, care models predominantly focus on acute medical and pharmacological needs. As a step towards holistic care, the aim ...

    Authors: Anouk Delameillieure, Fabienne Dobbels, Steffen Fieuws, Katleen Leceuvre, Sara Vanderauwera and Wim A. Wuyts
    Citation: Respiratory Research 2022 23:124

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