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  1. Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We...

    Authors: Takuya Aoki, Takeshi Akiba, Jun Nishiyama, Sakurako Tajiri, Naoki Hayama, Genki Takahashi, Jun Tanaka, Masako Sato, Hiroto Takiguchi, Hiromi Tomomatsu, Katsuyoshi Tomomatsu, Takahisa Takihara, Kyoko Niimi, Tsuyoshi Oguma, Mitsutomo Kohno, Ryota Masuda…

    Citation: Respiratory Research 2019 20:263

    Content type: Research

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  2. Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome of primary pulmonary LELC were...

    Authors: Bojiang Chen, Xuping Chen, Ping Zhou, Lan Yang, Jing Ren, Xiaodong Yang and Weimin Li

    Citation: Respiratory Research 2019 20:262

    Content type: Research

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  3. Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such,...

    Authors: Kalina R. Atanasova and Leah R. Reznikov

    Citation: Respiratory Research 2019 20:261

    Content type: Review

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  4. Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on long-t...

    Authors: Katharina Ruf, Wolfgang Thomas, Maximilian Brunner, Christian P. Speer and Helge Hebestreit

    Citation: Respiratory Research 2019 20:260

    Content type: Research

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  5. Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to...

    Authors: Rebecca L. Vanders, Alan Hsu, Peter G. Gibson, Vanessa E. Murphy and Peter A. B. Wark

    Citation: Respiratory Research 2019 20:259

    Content type: Research

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  6. Prognostic biomarkers in asthma are needed. The biomarker soluble urokinase plasminogen activator receptor (suPAR) has been associated with asthma control and with prognosis in acutely admitted medical patient...

    Authors: K. E. J. Håkansson, Line J. H. Rasmussen, Nina S. Godtfredsen, Oliver D. Tupper, Jesper Eugen-Olsen, Thomas Kallemose, Ove Andersen and Charlotte Suppli Ulrik

    Citation: Respiratory Research 2019 20:258

    Content type: Research

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  7. Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).

    Authors: Sarah Marietta von Siemens, Robert Perneczky, Claus F. Vogelmeier, Jürgen Behr, Diego Kauffmann-Guerrero, Peter Alter, Franziska C. Trudzinski, Robert Bals, Christian Grohé, Sandra Söhler, Benjamin Waschki, Johanna I. Lutter, Tobias Welte, Rudolf A. Jörres and Kathrin Kahnert

    Citation: Respiratory Research 2019 20:257

    Content type: Research

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  8. Distinct clinical presentations of interstitial lung disease (ILD) with the myositis-specific antibodies, including anti-synthetase antibodies, are well-recognized. However, the association between ILD and the...

    Authors: A. Sclafani, K. M. D’Silva, B. P. Little, E. M. Miloslavsky, J. J. Locascio, A. Sharma and S. B. Montesi

    Citation: Respiratory Research 2019 20:256

    Content type: Research

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  9. Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification and disordered angiogenesis. Stromal derived factor-1 (SDF-1) is a chemokine which modulates cell migration, proliferation, and angi...

    Authors: Kasonya Guerra, Carleene Bryan, Frederick Dapaah-Siakwan, Ibrahim Sammour, Shelly Drummond, Ronald Zambrano, Pingping Chen, Jian Huang, Mayank Sharma, Sebastian Shrager, Merline Benny, Shu Wu and Karen C. Young

    Citation: Respiratory Research 2019 20:255

    Content type: Research

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  10. Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix compo...

    Authors: J. Michael Wells, Dongqi Xing, Liliana Viera, Robert M. Burkes, Yixin Wu, Surya P. Bhatt, Mark T. Dransfield, David J. Couper, Wanda O’Neal, Eric A. Hoffman, Amit Gaggar, Igor Barjaktarevic, Jeffrey L. Curtis, Wassim W. Labaki, Mei Lan K. Han, Christine M. Freeman…

    Citation: Respiratory Research 2019 20:254

    Content type: Research

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  11. Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this ...

    Authors: David Pritchard, Ayodeji Adegunsoye, Elyse Lafond, Janelle Vu Pugashetti, Ryan DiGeronimo, Noelle Boctor, Nandini Sarma, Isabella Pan, Mary Strek, Michael Kadoch, Jonathan H. Chung and Justin M. Oldham

    Citation: Respiratory Research 2019 20:253

    Content type: Research

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  12. Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways...

    Authors: Amika K. Sood, Allison J. Burbank, Michael Lawson, Haibo Zhou, Heather B. Wells, David B. Peden and Michelle L. Hernandez

    Citation: Respiratory Research 2019 20:252

    Content type: Letter to the Editor

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  13. Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contr...

    Authors: Miyoko Tatsuta, Keiko Kan-o, Yumiko Ishii, Norio Yamamoto, Tomohiro Ogawa, Satoru Fukuyama, Aimi Ogawa, Akitaka Fujita, Yoichi Nakanishi and Koichiro Matsumoto

    Citation: Respiratory Research 2019 20:251

    Content type: Research

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  14. Balloon pulmonary angioplasty (BPA) has been demonstrated to improve cardiac function and exercise capacity in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but its instant im...

    Authors: Qi Jin, Qin Luo, Tao Yang, Qixian Zeng, Xue Yu, Lu Yan, Yi Zhang, Qing Zhao, Xiuping Ma, Chenhong An, Changming Xiong, Zhihui Zhao and Zhihong Liu

    Citation: Respiratory Research 2019 20:250

    Content type: Research

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  15. Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and scarring. The pathological mechanism causing pulmonary fibrosis remains unknown. Emerging evidence suggests prominent r...

    Authors: Chuyi Zhang, Xiaoping Zhu, Yifei Hua, Qian Zhao, Kaijing Wang, Lixiao Zhen, Guangxue Wang, Jinhui Lü, An Luo, William C. Cho, Xin Lin and Zuoren Yu

    Citation: Respiratory Research 2019 20:249

    Content type: Research

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  16. Small cell lung cancer (SCLC) is a highly aggressive lung cancer subtype with poor survival and limited treatment options. Sequencing results have revealed gene mutations associated with SCLC, however, the cor...

    Authors: Mengting Zhou, Jun Fan, Zhenyu Li, Pindong Li, Yajie Sun, Yuhui Yang, Xiaoshu Zhou, Jing Wang, Ye Wang, Huiwei Qi, Weijing Cai, Xiaofang Dai and Fred R. Hirsch

    Citation: Respiratory Research 2019 20:248

    Content type: Research

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  17. Chemical pleurodesis is a therapeutic procedure applied to create the symphysis between the parietal and visceral pleura by intrapleural administration of various chemical agents (e.g. talk, tetracycline, iodo...

    Authors: Michal Mierzejewski, Piotr Korczynski, Rafal Krenke and Julius P. Janssen

    Citation: Respiratory Research 2019 20:247

    Content type: Review

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  18. The lung microbiome maintains the homeostasis of the immune system within the lungs. In acute respiratory distress syndrome (ARDS), the lung microbiome is enriched with gut-derived bacteria; however, the speci...

    Authors: Michihito Kyo, Keisuke Nishioka, Takaaki Nakaya, Yoshiko Kida, Yuko Tanabe, Shinichiro Ohshimo and Nobuaki Shime

    Citation: Respiratory Research 2019 20:246

    Content type: Research

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  19. In acute respiratory distress syndrome (ARDS) damaged alveolar epithelium, leakage of plasma proteins into the alveolar space and inactivation of pulmonary surfactant lead to respiratory dysfunction. Lung func...

    Authors: J. Zebialowicz Ahlström, F. Massaro, P. Mikolka, R. Feinstein, G. Perchiazzi, O. Basabe-Burgos, T. Curstedt, A. Larsson, J. Johansson and A. Rising

    Citation: Respiratory Research 2019 20:245

    Content type: Research

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  20. T follicular helper (Tfh) cells have been identified as a new category of helper T cells, which express CXCR5 on their surface and induce the production of antigen-specific antibodies. Many investigations have...

    Authors: Yuichiro Asai, Hirofumi Chiba, Hirotaka Nishikiori, Ryuta Kamekura, Hayato Yabe, Shun Kondo, Satsuki Miyajima, Katsunori Shigehara, Shingo Ichimiya and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:244

    Content type: Research

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  21. Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age....

    Authors: Xizi Du, Lin Yuan, Mengping Wu, Meichao Men, Ruoxi He, Leyuan Wang, Shuangyan Wu, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chengping Hu, Ling Qin and Chi Liu

    Citation: Respiratory Research 2019 20:243

    Content type: Research

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  22. Guidelines recommend that treatment with a long-acting β2 agonist (LABA), a long-acting muscarinic antagonist (LAMA), and inhaled corticosteroids (ICS), i.e. triple therapy, is reserved for a select group of symp...

    Authors: Sue Langham, Jen Lewis, Nick Pooley, Nina Embleton, Julia Langham, MeiLan K. Han and James D. Chalmers

    Citation: Respiratory Research 2019 20:242

    Content type: Review

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  23. Revefenacin is a long-acting muscarinic antagonist that was recently approved for the nebulized treatment of chronic obstructive pulmonary disease (COPD). Although shorter duration studies have documented the ...

    Authors: James F. Donohue, Edward Kerwin, Sanjay Sethi, Brett Haumann, Srikanth Pendyala, Lorna Dean, Chris N. Barnes, Edmund J. Moran and Glenn Crater

    Citation: Respiratory Research 2019 20:241

    Content type: Research

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  24. Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on...

    Authors: Jonathan M. Carnino, Heedoo Lee and Yang Jin

    Citation: Respiratory Research 2019 20:240

    Content type: Review

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  25. Inflammation plays an important role in the pathogenesis of many lung diseases. Preclinical studies suggest that mesenchymal stromal cell (MSC) conditioned media (CdM) can attenuate inflammation. Our aim was t...

    Authors: Chimobi Emukah, Evan Dittmar, Rija Naqvi, John Martinez, Alexis Corral, Axel Moreira and Alvaro Moreira

    Citation: Respiratory Research 2019 20:239

    Content type: Review

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  26. Prospective evidence is lacking regarding incremental benefits of long-acting dual- versus mono-bronchodilation in improving symptoms and preventing short-term disease worsening/treatment failure in low exacer...

    Authors: François Maltais, Leif Bjermer, Edward M. Kerwin, Paul W. Jones, Michael L. Watkins, Lee Tombs, Ian P. Naya, Isabelle H. Boucot, David A. Lipson, Chris Compton, Mitra Vahdati-Bolouri and Claus F. Vogelmeier

    Citation: Respiratory Research 2019 20:238

    Content type: Research

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  27. In the BACE trial, a 3-month (3 m) intervention with azithromycin, initiated at the onset of an infectious COPD exacerbation requiring hospitalization, decreased the rate of a first treatment failure (TF); the...

    Authors: Kristina Vermeersch, Ann Belmans, Kris Bogaerts, Iwein Gyselinck, Nina Cardinaels, Maria Gabrovska, Joseph Aumann, Ingel K. Demedts, Jean-Louis Corhay, Eric Marchand, Hans Slabbynck, Christel Haenebalcke, Stefanie Vermeersch, Geert M. Verleden, Thierry Troosters, Vincent Ninane…

    Citation: Respiratory Research 2019 20:237

    Content type: Research

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  28. There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate t...

    Authors: Yilan Sun, Stephen Milne, Jen Erh Jaw, Chen Xi Yang, Feng Xu, Xuan Li, Ma’en Obeidat and Don D. Sin

    Citation: Respiratory Research 2019 20:236

    Content type: Research

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  29. As a consequence of the increased mortality observed in the SERVE-HF study, many questions concerning the safety and rational use of ASV in other indications emerged. The aim of this study was to describe the ...

    Authors: Dany Jaffuel, Carole Philippe, Claudio Rabec, Jean-Pierre Mallet, Marjolaine Georges, Stefania Redolfi, Alain Palot, Carey M. Suehs, Erika Nogue, Nicolas Molinari and Arnaud Bourdin

    Citation: Respiratory Research 2019 20:235

    Content type: Research

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  30. Asthma is a heterogenous disease characterized by chronic inflammation and airway remodeling. An increase in the severity of airway remodeling is associated with a more severe form of asthma. There is increasi...

    Authors: Alexandre Haddad, Mellissa Gaudet, Maria Plesa, Zoulfia Allakhverdi, Andrea K. Mogas, Severine Audusseau, Carolyn J. Baglole, David H. Eidelman, Ronald Olivenstein, Mara S. Ludwig and Qutayba Hamid

    Citation: Respiratory Research 2019 20:234

    Content type: Research

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  31. Accumulating evidence has shown the important roles of long non-coding RNAs (lncRNAs) in acute lung injury (ALI). This study aimed to investigate the potential role of lncRNA small nucleolar RNA host gene 14 (...

    Authors: Jinyuan Zhu, Jijia Bai, Shaojin Wang and Hui Dong

    Citation: Respiratory Research 2019 20:233

    Content type: Research

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  32. Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell...

    Authors: Peter Heukels, Jennifer A. C. van Hulst, Menno van Nimwegen, Carian E. Boorsma, Barbro N. Melgert, Jan H. von der Thusen, Bernt van den Blink, Rogier A. S. Hoek, Jelle R. Miedema, Stefan F. H. Neys, Odilia B. J. Corneth, Rudi W. Hendriks, Marlies S. Wijsenbeek and Mirjam Kool

    Citation: Respiratory Research 2019 20:232

    Content type: Research

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  33. The PROOF registry is an observational study initiated in October 2013 with the aim to monitor disease progression in a real-world population of patients with idiopathic pulmonary fibrosis (IPF). Here, we pres...

    Authors: Wim A. Wuyts, Caroline Dahlqvist, Hans Slabbynck, Marc Schlesser, Natacha Gusbin, Christophe Compere, Sofie Maddens, Yuan-Chi Lee, Klaus-Uwe Kirchgaessler, Karen Bartley and Benjamin Bondue

    Citation: Respiratory Research 2019 20:231

    Content type: Research

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  34. In mammalian cells, Aurora serine/threonine kinases (Aurora A, B, and C) are expressed in a cell cycle-dependent fashion as key mitotic regulators required for the maintenance of chromosomal stability. Aurora-...

    Authors: Ningbo Liu, Yong Antican Wang, Yunguang Sun, Jeffrey Ecsedy, Jifeng Sun, Xue Li and Ping Wang

    Citation: Respiratory Research 2019 20:230

    Content type: Research

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  35. Asthma-COPD overlap (ACO) is a term that encompasses patients with features of both asthma and COPD. To date, the global prevalence of ACO in the general population remains unknown. The objective of this study...

    Authors: Mostafa Hosseini, Amir Almasi-Hashiani, Mahdi Sepidarkish and Saman Maroufizadeh

    Citation: Respiratory Research 2019 20:229

    Content type: Review

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  36. Antiviral drugs such as rupintrivir may have an immune-modulatory effect in experimentally induced allergic asthma with subsequent RV infection. We infected lung slices of house-dust mite (HDM)-sensitized asth...

    Authors: Olga Danov, Lisa Lasswitz, Helena Obernolte, Christina Hesse, Armin Braun, Sabine Wronski and Katherina Sewald

    Citation: Respiratory Research 2019 20:228

    Content type: Research

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  37. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development....

    Authors: Jamie L. Todd, Megan L. Neely, Robert Overton, Katey Durham, Mridu Gulati, Howard Huang, Jesse Roman, L. Kristin Newby, Kevin R. Flaherty, Richard Vinisko, Yi Liu, Janine Roy, Ramona Schmid, Benjamin Strobel, Christian Hesslinger, Thomas B. Leonard…

    Citation: Respiratory Research 2019 20:227

    Content type: Research

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  38. Muscle wasting is associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). The cross-sectional area of skeletal muscles on computed tomography (CT) could serve as a method to ev...

    Authors: So Hyeon Bak, Sung Ok Kwon, Seon-Sook Han and Woo Jin Kim

    Citation: Respiratory Research 2019 20:226

    Content type: Research

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  39. Significant evidence has shown that the miRNA pathway is an important component in the downstream signaling cascades of TGF-β1 pathway. Our previous study has indicated that miR-335-5p expression was significa...

    Authors: Wenwen Du, Haicheng Tang, Zhe Lei, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu and Jian-an Huang

    Citation: Respiratory Research 2019 20:225

    Content type: Research

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  40. The incidence of infectious disease caused by nontuberculous mycobacteria is increasing worldwide. Pulmonary Mycobacterium avium complex (MAC) disease is difficult to treat with chemotherapy, and its mechanism of...

    Authors: Tomofumi Kobayashi, Koji Kuronuma, Atsushi Saito, Kimiyuki Ikeda, Shigeru Ariki, Atsushi Saitou, Mitsuo Otsuka, Hirofumi Chiba, Satoshi Takahashi, Motoko Takahashi and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:224

    Content type: Research

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  41. Primary drug-resistant tuberculosis (DR-TB) has contributed to a significant health and economic burden on a global scale, especially in China. we sought to estimate epidemiological characteristics of primary ...

    Authors: Wan-mei Song, Yi-fan Li, Xiao-bin Ma, Jin-yue Liu, Ning-ning Tao, Yao Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Chun-Bao Yu, Lei Gao, Liang-liang Cui and Huai-chen Li

    Citation: Respiratory Research 2019 20:223

    Content type: Research

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  42. Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impa...

    Authors: Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills and Alaina J. Ammit

    Citation: Respiratory Research 2019 20:222

    Content type: Review

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  43. Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease resulting in severe respiratory derangements. As such, DMD patients are at a high risk of nocturnal hypoventilation, thereby requiring n...

    Authors: Eli F. Kelley, Troy J. Cross, Eric M. Snyder, Craig M. McDonald, Eric P. Hoffman and Luca Bello

    Citation: Respiratory Research 2019 20:221

    Content type: Research

    Published on:

  44. Plasma metabolomics profile (PMP) in COPD has been associated with clinical characteristics, but PMP’s relationship to survival has not been reported. We determined PMP differences between patients with COPD w...

    Authors: Victor Pinto-Plata, Ciro Casanova, Miguel Divo, Yohannes Tesfaigzi, Vince Calhoun, Jing Sui, Francesca Polverino, Carmen Priolo, Hans Petersen, Juan Pablo de Torres, Jose Maria Marin, Caroline A. Owen, Rebeca Baz, Elizabeth Cordova and Bartolome Celli

    Citation: Respiratory Research 2019 20:219

    Content type: Research

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  45. Respiratory pathology is a major driver of mortality in the intensive care unit (ICU), even in the absence of a primary respiratory diagnosis. Prior work has demonstrated that a visual scoring system applied t...

    Authors: Stefanie E. Mason, Paul B. Dieffenbach, Joshua A. Englert, Angela A. Rogers, Anthony F. Massaro, Laura E. Fredenburgh, Angelica Higuera, Mayra Pinilla-Vera, Marta Vilas, Raul San Jose Estepar, George R. Washko, Rebecca M. Baron and Samuel Y. Ash

    Citation: Respiratory Research 2019 20:218

    Content type: Research

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  46. Icotinib has been widely used in patients with non-small cell lung cancer (NSCLC), and have significantly enhanced the overall survival rate of NSCLC patients. However, acquired drug resistance limits its clin...

    Authors: Yiming Yu, Maidinaimu Abudula, Chaofen Li, Zhongbo Chen, Yun Zhang and Yichen Chen

    Citation: Respiratory Research 2019 20:217

    Content type: Research

    Published on:

  47. Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolu...

    Authors: Bora Sul, Lucia Flors, Joanne Cassani, Michael J. Morris, Jaques Reifman, Talissa Altes and Anders Wallqvist

    Citation: Respiratory Research 2019 20:216

    Content type: Research

    Published on:

  48. Evidence on the economic impact of chronic obstructive pulmonary disease (COPD) for third-party payers and society based on large real world datasets are still scarce. Therefore, the aim of this study was to e...

    Authors: Florian Kirsch, Anja Schramm, Larissa Schwarzkopf, Johanna I. Lutter, Boglárka Szentes, Manuel Huber and Reiner Leidl

    Citation: Respiratory Research 2019 20:215

    Content type: Research

    Published on:

  49. There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation be...

    Authors: Jian Liu, Yong-Quan Dong, Jie Yin, Jian Yao, Jie Shen, Guo-Jie Sheng, Kun Li, Hai-Feng Lv, Xing Fang and Wei-Fang Wu

    Citation: Respiratory Research 2019 20:161

    Content type: Research

    Published on:

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