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  1. While well-characterised on its molecular base, non-small cell lung cancer (NSCLC) and its interaction with local microbiota remains scarcely explored. Moreover, current studies vary in source of lung microbio...

    Authors: Rea Bingula, Edith Filaire, Ioana Molnar, Eve Delmas, Jean-Yves Berthon, Marie-Paule Vasson, Annick Bernalier-Donadille and Marc Filaire

    Citation: Respiratory Research 2020 21:129

    Content type: Research

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  2. The Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting bronchodilator for chronic obstructive pulmonary disease...

    Authors: Fernando J. Martinez, Brian J. Lipworth, Klaus F. Rabe, David J. Collier, Gary T. Ferguson, Sanjay Sethi, Gregory J. Feldman, Gerald O’Brien, Martin Jenkins and Colin Reisner

    Citation: Respiratory Research 2020 21:128

    Content type: Research

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  3. The objective of this study was to analyze prognostic factors and risk stratification in patients with pulmonary arterial hypertension (PAH) and comorbidities.

    Authors: Panagiota Xanthouli, Maria Koegler, Alberto M. Marra, Nicola Benjamin, Lukas Fischer, Christina A. Eichstaedt, Satenik Harutyunova, Christian Nagel, Ekkehard Grünig and Benjamin Egenlauf

    Citation: Respiratory Research 2020 21:127

    Content type: Research

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  4. Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging fo...

    Authors: Nilanjana Ghosh, Priyanka Choudhury, Sandeep Rai Kaushik, Rakesh Arya, Ranjan Nanda, Parthasarathi Bhattacharyya, Sushmita Roychowdhury, Rintu Banerjee and Koel Chaudhury

    Citation: Respiratory Research 2020 21:126

    Content type: Research

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  5. A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at e...

    Authors: Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang and Bo Liang

    Citation: Respiratory Research 2020 21:125

    Content type: Research

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  6. One of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated th...

    Authors: Gerald Birk, Marc Kästle, Cornelia Tilp, Birgit Stierstorfer and Stephan Klee

    Citation: Respiratory Research 2020 21:124

    Content type: Research

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  7. Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respirat...

    Authors: Jinzhun Wu, Dandan Ge, Taoling Zhong, Zuojia Chen, Ying Zhou, Lingyun Hou, Xiaoliang Lin, Jiaxu Hong, Kuai Liu, Hui Qi, Chaoying Wang, Yulin Zhou, Cheng Li, Chuan Wu, Shuiping Wu, Zuguo Liu…

    Citation: Respiratory Research 2020 21:123

    Content type: Research

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  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alex J. van ’t Hul, Noortje H. Koolen, Jeroen W. van Hees, Bram van den Borst and Martijn A. Spruit

    Citation: Respiratory Research 2020 21:122

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:112

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Margaret Gilfillan, Pragnya Das, Dilip Shah, Mohammad Afaque Alam and Vineet Bhandari

    Citation: Respiratory Research 2020 21:121

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:92

  10. The predominant metastatic site of lung cancer (LC) is the brain. Although outdated, conventional cisplatin treatment is still the main therapeutic approach for patients with advanced non-small cell lung cance...

    Authors: Edit Kiss, El Husseiny Mohamed Mahmud Abdelwahab, Anita Steib, Emoke Papp, Zsofia Torok, Laszlo Jakab, Gabor Smuk, Veronika Sarosi and Judit Erzsebet Pongracz

    Citation: Respiratory Research 2020 21:120

    Content type: Research

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  11. Progression of the disease in idiopathic pulmonary fibrosis (IPF) is difficult to predict, due to its variable and heterogenous course. The relationship between radiographic progression and functional decline ...

    Authors: Nada Taha, Dejanira D’Amato, Karishma Hosein, Tiziana Ranalli, Gianluigi Sergiacomi, Maurizio Zompatori and Marco Mura

    Citation: Respiratory Research 2020 21:119

    Content type: Research

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  12. Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive statins. ...

    Authors: AJN Raymakers, D. D. Sin, M. Sadatsafavi, JM FitzGerald, C. A. Marra and L. D. Lynd

    Citation: Respiratory Research 2020 21:118

    Content type: Research

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  13. Targeted lung denervation (TLD), a novel bronchoscopic procedure which attenuates pulmonary nerve input to the lung to reduce the clinical consequences of neural hyperactivity, may be an important emerging tre...

    Authors: Martin L. Mayse, Holly S. Norman, Alexander D. Peterson, Kristina T. Rouw and Philip J. Johnson

    Citation: Respiratory Research 2020 21:117

    Content type: Research

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  14. This study was conducted to evaluate the relationship between nasal resistance in different posture and optimal positive airway pressure (PAP) level. Other potential factors were also assessed for possible inf...

    Authors: Yen-Bin Hsu, Stanley Yung-Chuan Liu, Ming-Ying Lan, Yun-Chen Huang, I-Shiang Tzeng and Ming-Chin Lan

    Citation: Respiratory Research 2020 21:115

    Content type: Research

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  15. High FiO2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E1 (PGE1) can improve oxy...

    Authors: Pengyi Li, Lianbing Gu, Qingming Bian, Jing Tan, Dian Jiao, Fei Wu, Zeping Xu and Lijun Wang

    Citation: Respiratory Research 2020 21:113

    Content type: Research

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  16. Authors: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit

    Citation: Respiratory Research 2020 21:112

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:122

    The original article was published in Respiratory Research 2020 21:27

    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:114

  17. Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number o...

    Authors: Ryan Brown, Sridesh Nath, Alnardo Lora, Ghassan Samaha, Ziyad Elgamal, Ryan Kaiser, Clifford Taggart, Sinéad Weldon and Patrick Geraghty

    Citation: Respiratory Research 2020 21:111

    Content type: Review

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  18. The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective i...

    Authors: Sirous Sadeghian Chaleshtori, Mohammad Reza Mokhber Dezfouli and Massoumeh Jabbari Fakhr

    Citation: Respiratory Research 2020 21:110

    Content type: Review

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  19. The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

    Authors: Liang Chen, Xiudi Han, Yan Li Li, Chunxiao Zhang and Xiqian Xing

    Citation: Respiratory Research 2020 21:109

    Content type: Research

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  20. Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

    Authors: Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese, Carmel B. Nanthakumar, Vikki J. Barrett, Robert B. Good, Sarah Brockbank, Simon Cruwys, Henrik Jessen, Grith Lykke Sorensen, Morten Asser Karsdal, Diana Julie Leeming and Jannie Marie Bülow Sand

    Citation: Respiratory Research 2020 21:108

    Content type: Research

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  21. Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

    Authors: Julie Weidner, Linda Ekerljung, Carina Malmhäll, Nicolae Miron and Madeleine Rådinger

    Citation: Respiratory Research 2020 21:107

    Content type: Research

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  22. In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...

    Authors: Timm Greulich, Julia Tüffers, Sina Mager, Anna Eder, Michael Maxheim, Peter Alter, Bernd Schmeck and Claus F. Vogelmeier

    Citation: Respiratory Research 2020 21:106

    Content type: Research

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  23. Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

    Authors: Nirmal S. Sharma, Grant Vestal, Keith Wille, Kapil N. Patel, Feng Cheng, Srinivas Tipparaju, Sultan Tousif, Mudassir M. Banday, Xin Xu, Landon Wilson, Viswam S. Nair, Casey Morrow, Don Hayes Jr, Andreas Seyfang, Stephen Barnes, Jessy S. Deshane…

    Citation: Respiratory Research 2020 21:104

    Content type: Research

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  24. Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, James D. Crapo, Barry J. Make, David A. Lynch, Vito Brusasco, Federico Lavorini, Edwin K. Silverman, Elizabeth A. Regan and Massimo Pistolesi

    Citation: Respiratory Research 2020 21:103

    Content type: Research

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  25. In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

    Authors: Yanan Yin, Ganesh Vilas Shelke, Cecilia Lässer, Hjalmar Brismar and Jan Lötvall

    Citation: Respiratory Research 2020 21:101

    Content type: Research

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  26. Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

    Authors: Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko…

    Citation: Respiratory Research 2020 21:100

    Content type: Research

    Published on:

  27. There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

    Authors: Jing Xu, Tingting Pan, Xiaoling Qi, Ruoming Tan, Xiaoli Wang, Zhaojun Liu, Zheying Tao, Hongping Qu, Yi Zhang, Hong Chen, Yihui Wang, Jingjing Zhang, Jie Wang and Jialin Liu

    Citation: Respiratory Research 2020 21:99

    Content type: Research

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  28. Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...

    Authors: David I. Kasahara and Stephanie A. Shore

    Citation: Respiratory Research 2020 21:98

    Content type: Research

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  29. Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor pro...

    Authors: Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian and Jill A. Poole

    Citation: Respiratory Research 2020 21:97

    Content type: Research

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  30. The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease pr...

    Authors: Jing Gao, Jun-Qiang Liu, Heng-Jun Wen, Hua Liu, Wei-Dong Hu, Xia Han, Chuan-Xing Li and Xiao-Jun Wang

    Citation: Respiratory Research 2020 21:96

    Content type: Letter to the Editor

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  31. It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and ...

    Authors: Xiaomin Dang, Beibei He, Qian Ning, Ya Liu, Jianxin Guo, Gang Niu and Mingwei Chen

    Citation: Respiratory Research 2020 21:95

    Content type: Research

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  32. A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO2/FlO2, and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasi...

    Authors: Hyeontaek Hwang, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Sang-Min Lee

    Citation: Respiratory Research 2020 21:94

    Content type: Research

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  33. COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.

    Authors: Alexander J. Mackay, Konstantinos Kostikas, Nicolas Roche, Stefan-Marian Frent, Petter Olsson, Pascal Pfister, Pritam Gupta, Francesco Patalano, Donald Banerji and Jadwiga A. Wedzicha

    Citation: Respiratory Research 2020 21:93

    Content type: Research

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  34. Macrophage migration inhibitory factor (MIF) has been implicated as a protective factor in the development of bronchopulmonary dysplasia (BPD) and is known to be regulated by MicroRNA-451 (miR-451). The aim of...

    Authors: Margaret Gilfillan, Pragnya Das, Dilip Shah, Mohammad Afaque Alam and Vineet Bhandari

    Citation: Respiratory Research 2020 21:92

    Content type: Research

    Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:121

  35. Idiopathic pulmonary fibrosis (IPF) specific version of St. George’s Respiratory Questionnaire (SGRQ-I) and King’s Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Ole Hilberg, Saher Burhan Shaker, Jesper Rømhild Davidsen and Elisabeth Bendstrup

    Citation: Respiratory Research 2020 21:91

    Content type: Research

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  36. Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obs...

    Authors: Andreas Scherr, Desiree M. Schumann, Meropi Karakioulaki, Léo Franchetti, Werner Strobel, Michael Zellweger, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2020 21:90

    Content type: Research

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  37. Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in th...

    Authors: Andrzej S. Swinarew, Arkadiusz J. Stanula, Jadwiga Gabor, Paweł Raif, Jarosław Paluch, Jakub Karpiński, Klaudia Kubik, Hubert Okła, Andrzej Ostrowski, Ewaryst Tkacz, Szymon Skoczyński, Zbigniew Waśkiewicz, Thomas Rosemann, Pantelis T. Nikolaidis and Beat Knechtle

    Citation: Respiratory Research 2020 21:88

    Content type: Research

    Published on:

  38. Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatme...

    Authors: Henrik Watz, Jens M. Hohlfeld, Dave Singh, Jutta Beier, Zuzana Diamant, Jinming Liu, Shucheng Hua, Khalid Abd-Elaziz, Pascale Pinot, Ieuan Jones and Hanns-Christian Tillmann

    Citation: Respiratory Research 2020 21:87

    Content type: Letter to the Editor

    Published on:

  39. Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism,...

    Authors: Yipeng Ding, Yixiu Yang, Quanni Li, Qiong Feng, Dongchuan Xu, Cibing Wu, Jie Zhao, Xiaoli Zhou, Huan Niu, Ping He, Jianfang Liu and Hongxia Yao

    Citation: Respiratory Research 2020 21:86

    Content type: Research

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  40. Intraoperative Extracorporeal membrane oxygenation (ECMO) is increasingly being applied as life-support for lung transplantation patients. However, factors associated with this procedure in lung transplantatio...

    Authors: Rong Zhang, Yonghao Xu, Ling Sang, Sibei Chen, Yongbo Huang, Lingbo Nong, Chun Yang, Xuesong Liu, Dongdong Liu, Yin Xi, Weiqun He, Bing Wei, Jianxing He, Yimin Li and Xiaoqing Liu

    Citation: Respiratory Research 2020 21:85

    Content type: Research

    Published on:

  41. Chronic obstructive pulmonary disease (COPD) is airway inflammation characterized and low daily physical activity. Most pulmonary rehabilitation (PR) programs are often provided to stable patients, but fewer t...

    Authors: Lan-Fang Tung, Sheng-Yeh Shen, Hui-Hsuan Shih, Yen-Ting Chen, Chia-te Yen and Shu-Chuan Ho

    Citation: Respiratory Research 2020 21:84

    Content type: Research

    Published on:

  42. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The car...

    Authors: Lei Gao, Dan Jiang, Xue-song Wen, Xiao-cheng Cheng, Min Sun, Bin He, Lin-na You, Peng Lei, Xiao-wei Tan, Shu Qin, Guo-qiang Cai and Dong-ying Zhang

    Citation: Respiratory Research 2020 21:83

    Content type: Research

    Published on:

  43. Diabetes mellitus causes the deterioration of smooth muscle cells and interstitial matrix proteins, including collagen. Collagen and smooth muscle cells are abundant in the lungs, but the effect of diabetes on...

    Authors: Roberta Südy, Álmos Schranc, Gergely H. Fodor, József Tolnai, Barna Babik and Ferenc Peták

    Citation: Respiratory Research 2020 21:82

    Content type: Research

    Published on:

  44. Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of A...

    Authors: Adrien Carla, Bruno Pereira, Hanifa Boukail, Jules Audard, Nathalie Pinol-Domenech, Manuela De Carvalho, Raiko Blondonnet, Ruoyang Zhai, Dominique Morand, Céline Lambert, Vincent Sapin, Lorraine B. Ware, Carolyn S. Calfee, Julie A. Bastarache, John G. Laffey, Nicole P. Juffermans…

    Citation: Respiratory Research 2020 21:81

    Content type: Study protocol

    Published on:

  45. Adolescence is a significant period for the gender-dependent development of lung function. Prior studies have shown that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phos...

    Authors: Shadia Khan Sunny, Hongmei Zhang, Faisal I. Rezwan, Caroline L. Relton, A. John Henderson, Simon Kebede Merid, Erik Melén, Jenny Hallberg, S. Hasan Arshad, Susan Ewart and John W. Holloway

    Citation: Respiratory Research 2020 21:80

    Content type: Research

    Published on:

  46. Chronic respiratory diseases constitute a considerable part in the practice of pulmonologists and primary care physicians; spirometry is integral for the diagnosis and monitoring of these diseases, yet remains...

    Authors: Konstantinos P. Exarchos, Athena Gogali, Agni Sioutkou, Christos Chronis, Sofia Peristeri and Konstantinos Kostikas

    Citation: Respiratory Research 2020 21:79

    Content type: Research

    Published on:

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