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Coronavirus research collection

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To help keep our readers up-to-date on research and analysis related to the COVID-19 pandemic, we have created this collection of articles and other resources published in Respiratory Research. New articles will be added on a monthly basis.

Dysregulation of COVID-19 related gene expression in the COPD lung
Alastair Watson, Lisa Öberg, Bastian Angermann, C. Mirella Spalluto, Michael Hühn, Hannah Burke, Doriana Cellura, Anna Freeman
Research  |   Published: 29 May 2021

Real-life cost-effectiveness of benralizumab in patients with severe asthma
A. Padilla-Galo, A. J. García-Ruiz, R. Ch. Levy Abitbol, C. Olveira, F. Rivas-Ruiz, N. García-Agua Soler, M. Pérez Morales, B. Valencia Azcona
Research  |   Published: 27 May 2021

Use of capnography for prediction of obstruction severity in non-intubated COPD and asthma patients
Barak Pertzov, Michal Ronen, Dror Rosengarten, Dorit Shitenberg, Moshe Heching, Yael Shostak, Mordechai R. Kramer
Research  |   Published: 21 May 2021

Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed COVID-19
T. J. M. Wallis, E. Heiden, J. Horno, B. Welham, H. Burke, A. Freeman, L. Dexter, A. Fazleen
Research  |   Published: 21 May 2021

Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis
Claudia Gregoriano, Dominik Damm, Alexander Kutz, Daniel Koch, Selina Wolfisberg, Sebastian Haubitz, Anna Conen, Luca Bernasconi
Research  |   Published: 13 May 2021

SARS-CoV-2 serology increases diagnostic accuracy in CT-suspected, PCR-negative COVID-19 patients during pandemic
Jochen Schneider, Hrvoje Mijočević, Kurt Ulm, Bernhard Ulm, Simon Weidlich, Silvia Würstle, Kathrin Rothe, Matthias Treiber
Research  |   Published: 23 April 2021

Vitamin D levels in acute illness and clinical severity in COVID-19 patients
Prateek Lohia, Shweta Kapur, Pragnesh Patel, Berhane Seyoum
Letter to the Editor  |   Published: 9 April 2021

Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions
Atish Gheware, Dhwani Dholakia, Sadasivam Kannan, Lipsa Panda, Ritu Rani, Bijay Ranjan Pattnaik, Vaibhav Jain, Yash Parekh
Research  |   Published: 6 April 2021

The combination of initial markers to predict refractory Mycoplasma pneumoniae pneumonia in Chinese children: a case control study
Jun Wen, Yufei Su, Hongli Sun, Huiping Zhang, Hui Li
Research  |   Published: 22 March 2021

The impact of the involvement of a healthcare professional on the usage of an eHealth platform: a retrospective observational COPD study
Cathelijne M. van Zelst, Marise J. Kasteleyn, Esther M. J. van Noort, Maureen P. M. H. Rutten - van Molken, Gert-Jan Braunstahl, Niels H. Chavannes, Johannes C. C. M. in ’t Veen
Research  |   Published: 21 March 2021

Predictors of mortality in COPD exacerbation cases presenting to the respiratory intensive care unit
Yang Cao, Zhenzhen Xing, Huanyu Long, Yilin Huang, Ping Zeng, Jean-Paul Janssens, Yanfei Guo
Research  |   Published: 4 March 2021

Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
Alberto Ricci, Alessandra Pagliuca, Michela D’Ascanio, Marta Innammorato, Claudia De Vitis, Rita Mancini, Simonetta Giovagnoli, Francesco Facchiano
Research  |   Published: 3 March 2021

IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma
Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight
Research  |   Published: 2 March 2021

Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells
Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin, Delbert R. Dorscheid
Research  |   Published: 23 February 2021

Does pulmonary subspecialty referral from primary care affect the adherence to vaccination recommendations in COPD patients?
Solmaz Ehteshami-Afshar, Kristina Crothers, Benjamin Rodwin, Brett Bade, Cynthia Brandt, Kathleen M. Akgün
Letter to the Editor  |   Published: 12 February 2021

The role of viral and bacterial infections in the pathogenesis of IPF: a systematic review and meta-analysis
Shayan Mostafaei, Babak Sayad, Maryam Ebadi Fard Azar, Mohammad Doroudian, Shima Hadifar, Ava Behrouzi, Parisa Riahi, Bashdar Mahmud Hussen
Review  |   Published: 12 February 2021

S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway
Boying Zhao, Renfu Lu, Jianjun Chen, Ming Xie, Xingji Zhao, Lingwen Kong
Research  |   Published: 6 February 2021

Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis
D. J. Leeming, F. Genovese, J. M. B. Sand, D. G. K. Rasmussen, C. Christiansen, G. Jenkins, T. M. Maher, J. Vestbo
Letter to the Editor  |   Published: 5 February 2021

Preexisting respiratory diseases and clinical outcomes in COVID-19: a multihospital cohort study on predominantly African American population
Prateek Lohia, Kalyan Sreeram, Paul Nguyen, Anita Choudhary, Suman Khicher, Hossein Yarandi, Shweta Kapur, M. Safwan Badr
Research  |   Published: 5 February 2021

Tracking the time course of pathological patterns of lung injury in severe COVID-19
Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Ellen Pierre de Oliveira, Jose Mara de Brito, Ellen Caroline Toledo do Nascimento, Renata Aparecida de Almeida Monteiro, Juliana Carvalho Ferreira
Research  |   Published: 29 January 2021

Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission
Laurent Truffaut, Lucas Demey, Anne Violette Bruyneel, Alain Roman, Stephane Alard, Nathalie De Vos, Marie Bruyneel
Letter to the Editor  |   Published: 21 January 2021

Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19
Georgios D. Kitsios, William Bain, Nameer Al-Yousif, Radha Duttagupta, Asim A. Ahmed, Bryan J. McVerry, Alison Morris
Letter to the Editor  |   Published: 20 January 2021

Surfactant therapy for COVID-19 related ARDS: a retrospective case–control pilot study
Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni
Research  |   Published: 18 January 2021

More skilled clinical management of COVID-19 patients modified mortality in an intermediate respiratory intensive care unit in Italy
Giovanna E. Carpagnano, Giovanni Migliore, Salvatore Grasso, Vito Procacci, Emanuela Resta, Francesco Panza, Onofrio Resta
Research  |   Published: 15 January 2021

Ruling out COVID-19 by chest CT at emergency admission when prevalence is low: the prospective, observational SCOUT study
Ulf Teichgräber, Amer Malouhi, Maja Ingwersen, Rotraud Neumann, Marina Reljic, Stefanie Deinhardt-Emmer, Bettina Löffler, Wilhelm Behringer
Research  |   Published: 12 January 2021

Conceptions of the pathophysiology of happy hypoxemia in COVID-19
Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt, Bart N. Lambrecht
Letter to the Editor  |   Published: 08 January 2021

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth
Research  |   Published: 07 January 2021

Happy hypoxemia, or blunted ventilation?
Josuel Ora, Paola Rogliani, Mario Dauri, Denis O’Donnell
Letter to the Editor  |   Published: 06 January 2021

A super-spreader of SARS-CoV-2 in incubation period among health-care workers
Chaojie Wei, Yufeng Yuan, Zhenshun Cheng
Letter to the Editor  |   Published: 10 December 2020

Bronchoscopist's perception of the quality of the single-use bronchoscope (Ambu aScope4™) in selected bronchoscopies: a multicenter study in 21 Spanish pulmonology services
Javier Flandes, Luis Fernando Giraldo-Cadavid, Javier Alfayate, Iker Fernández-Navamuel, Carlos Agusti, Carmen M. Lucena, Antoni Rosell, Felipe Andreo
Research  |   Published: 02 December 2020

SARS coronavirus 2: from genome to infectome
Meghana Rastogi, Neha Pandey, Astha Shukla, Sunit K. Singh
Review  |   Published: 01 December 2020

Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China
Siqin Zhang, Lin Liu, Bin Yang, Rou Li, Jianhua Luo, Jing Huang, Yanjun Long, Ying Huang
Research  |   Published: 26 November 2020

The differences of clinical characteristics and outcomes between imported and local patients of COVID-19 in Hunan: a two-center retrospective study
Chang Wang, Lizhi Zhou, Juan Chen, Yong Yang, Tianlong Huang, Min Fu, Ya Li, Daniel M. George
Research  |   Published: 26 November 2020

Could KL-6 levels in COVID-19 help to predict lung disease?
A N Frix, L Schoneveld, A Ladang, M Henket, B Duysinx, F Vaillant, B Misset, M Moutschen
Letter to the Editor  |   Published: 24 November 2020

Are there pulmonary sequelae in patients recovering from COVID-19?
Paola Rogliani, Luigino Calzetta, Angelo Coppola, Ermanno Puxeddu, Gianluigi Sergiacomi, Dejanira D’Amato, and Antonio Orlacchio
Letter to the Editor  |   Published: 30 October 2020

Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium
Yosuke Kamiya, Tomoyuki Fujisawa, Mineo Katsumata, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Hironao Hozumi, and Kazuki Furuhashi
Research  |   Published: 27 October 2020

Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study
Sijing Cheng, Dingfeng Wu, Jie Li, Yifeng Zou, Yunle Wan, Lihan Shen, Lixin Zhu, and Mang Shi
Research  |   Published: 21 October 2020

DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Andrew Menzies-Gow, Sandhia Ponnarambil, John Downie, Karin Bowen, Åsa Hellqvist, and Gene ColiceStudy Protocol  |   Published: 21 October 2020

Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study
Thomas Sonnweber, Anna Boehm, Sabina Sahanic, Alex Pizzini, Magdalena Aichner, Bettina Sonnweber, Katharina Kurz, and Sabine Koppelstätter
Research  |   Published: 21 October 2020

SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma
Michael E. Wechsler, Gene Colice, Janet M. Griffiths, Gun Almqvist, Tor Skärby, Teresa Piechowiak, Primal Kaur, and Karin Bowen
Study Protocol  |   Published: 13 October 2020

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
Claire Emson, Sarah Diver, Latifa Chachi, Ayman Megally, Cherrie Small, John Downie, Jane R. Parnes, and Karin Bowen
Study Protocol  |   Published: 13 October 2020

NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma
Andrew Menzies-Gow, Gene Colice, Janet M. Griffiths, Gun Almqvist, Sandhia Ponnarambil, Primal Kaur, Gennaro Ruberto, and Karin Bowen
Study Protocol  |   Published: 13 October 2020

Functional analysis and evaluation of respiratory cilia in healthy Chinese children
So-Lun Lee, Christopher O’Callaghan, Yu-Lung Lau, and Chun-Wai Davy Lee
Research  |   Published: 9 October 2020

COVID-19 multidisciplinary high dependency unit: the Milan model
Stefano Aliberti, Francesco Amati, Maria Pappalettera, Marta Di Pasquale, Alice D’Adda, Marco Mantero, Andrea Gramegna, and Edoardo Simonetta
Review  |   Published: 9 October 2020

Hypoxemia in COVID-19: cerebral oximetry should be explored as a warning indicator for mechanically ventilated adults with COVID-19
Marco Ferrari and Valentina Quaresima
Letter to the Editor  
|   Published: 9 October 2020

Epidemiological characteristics and the entire evolution of coronavirus disease 2019 in Wuhan, China
Dongming Wang, Jing Cai, Tingming Shi, Yang Xiao, Xiaobing Feng, Meng Yang, Wenzhen Li, and Wei Liu
Research  |   Published: 8 October 2020

Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
Magdalena Matusiak and Christian M. Schürch
Letter to the Editor  |   Published: 29 September 2020

Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
Martin J. Tobin, Amal Jubran, and Franco Laghi
Letter to the Editor  |   Published: 24 September 2020

Inflammatory phenotyping predicts clinical outcome in COVID-19
H. Burke, A. Freeman, D. C. Cellura, B. L. Stuart, N. J. Brendish, S. Poole, F. Borca, and H. T. T. Phan
Research  |   Published: 22 September 2020

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study
Houwei Du, Xiaobin Pan, Nan Liu, Junnian Chen, Xiaoling Chen, David J. Werring, Gareth Ambler, and Xiaoqing Li
Research  |   Published: 21 September 2020

Pneumothorax in COVID-19 disease- incidence and clinical characteristics
Massa Zantah, Eduardo Dominguez Castillo, Ryan Townsend, Fusun Dikengil, and Gerard J. Criner
Research  |   Published: 16 September 2020

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses
 Zhixing Zhu, Xihua Lian, Xiaoshan Su, Weijing Wu, Giuseppe A. Marraro, Yiming Zeng
Review  |   Published: 27 August 2020

Association between cytokine profiles and lung injury in COVID-19 pneumonia
Li-Da Chen, Zhen-Yu Zhang, Xiao-Jie Wei, Yu-Qing Cai, Weng-Zhen Yao, Ming-Hui Wang, Qiu-Fen Huang, and Xiao-Bin Zhang
Research  |   Published: 29 July 2020

The pathophysiology of ‘happy’ hypoxemia in COVID-19
Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt, and Bart N. Lambrecht
Review  |   Published: 28 July 2020

Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
Xiaofan Lu, Liyun Jiang, Taige Chen, Yang Wang, Bing Zhang, Yizhou Hong, Jun Wang, and Fangrong Yan
Letter to the Editor  |   Published: 22 July 2020

Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
Ga-Yeon Kim, Insoo Rheem, You Hyun Joung, and Jae Kyung Kim
Research  |   Published: 18 July 2020

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis
Jincheng Xu, Xiaoyue Xu, Lina Jiang, Kamal Dua, Philip M. Hansbro, and Gang Liu
Research  |   Published: 14 July 2020

Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China
Jie Zhang, Guangping Meng, Wei Li, Bingqing Shi, Hongna Dong, Zhenzhong Su, Qian Huang, and Peng Gao
Research  |   Published: 14 July 2020

The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
Marcos Pereira, Enny Paixão, Anete Trajman, Ramon Andrade de Souza, Marcio Santos da Natividade, Julia M. Pescarini, Susan Martins Pereira, and Florisneide Rodrigues Barreto
Letter to the Editor  |   Published: 11 July 2020

Effect of hypertension on outcomes of adult inpatients with COVID-19 in Wuhan, China: a propensity score–matching analysis
Qing Yang, Ying Zhou, Xinrong Wang, Shan Gao, Yang Xiao, Weiming Zhang, Yi Hu, and Yafei Wang
Research  |   Published: 06 July 2020

Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia
Mei-ying Wu, Lin Yao, Yi Wang, Xin-yun Zhu, Xia-fang Wang, Pei-jun Tang, and Cheng Chen
Research  |   Published: 06 July 2020

Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19
Wenjing Ye, Guoxi Chen, Xiaopan Li, Xing Lan, Chen Ji, Min Hou, Di Zhang, and Guangwang Zeng
Research  |   Published: 03 July 2020

Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase
Yiying Huang, Cuiyan Tan, Jian Wu, Meizhu Chen, Zhenguo Wang, Liyun Luo, Xiaorong Zhou, Xinran Liu
Research  |   Published: 29 June 2020

Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses
Louisa L. Y. Chan, John M. Nicholls, J. S. Malik Peiris, Yu Lung Lau, Michael C. W. Chan, Renee W. Y. Chan
Research  |   Published: 23 June 2020

Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study
Changzhi Zhou, Zhe Huang, Weijun Tan, Xueying Li, Wen Yin, Yang Xiao, Zhaowu Tao, and Shuang Geng
Research  |   Published: 22 June 2020

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation
Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough, and Irfan Rahman
Research  |   Published: 18 June 2020

Predictors of fatality including radiographic findings in adults with COVID-19
Kaiyan Li, Dian Chen, Shengchong Chen, Yuchen Feng, Chenli Chang, Zi Wang, Nan Wang, and Guohua Zhen
Research  |   Published: 11 June 2020

The pulmonary sequalae in discharged patients with COVID-19: a short-term observational study
Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang, and Bo Liang
Research  |   Published: 24 May 2020

FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients
Liang Chen, Xiudi Han, Yan Li Li, Chunxiao Zhang, Xiqian Xing
Research  |   Published: 08 May 2020

The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China
Jing Gao, Jun-Qiang Liu, Heng-Jun Wen, Hua Liu, Wei-Dong Hu, Xia Han, Chuan-Xing Li, and Xiao-Jun Wang
Letter to the Editor  |   Published: 22 April 2020

Prognostic value of NT-proBNP in patients with severe COVID-19
Lei Gao, Dan Jiang, Xue-song Wen, Xiao-cheng Cheng, Min Sun, Bin He, Lin-na You, and Peng Lei
Research  |   Published: 15 April 2020

Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort
Jerome Bouquet, David E. Tabor, Jonathan S. Silver, Varsha Nair, Andrey Tovchigrechko, M. Pamela Griffin, Mark T. Esser, and Bret R. Sellman
Research  |   Published: 30 March 2020

Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis
Gemin Zhang, Jie Zhang, Bowen Wang, Xionglin Zhu, Qiang Wang, and Shiming Qiu
Research  |   Published: 26 March 2020

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