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  1. Fueled by the promise of regenerative medicine, currently there is unprecedented interest in stem cells. Furthermore, there have been revolutionary, but somewhat controversial, advances in our understanding of...

    Authors: Isabel P Neuringer and Scott H Randell
    Citation: Respiratory Research 2004 5:6
  2. The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma. These compoun...

    Authors: Robert A Clayton, Colin AJ Dick, Alison Mackenzie, Michiaki Nagasawa, Deirdre Galbraith, Stuart F Hastings and Simon J MacKenzie
    Citation: Respiratory Research 2004 5:4
  3. The relative contributions of the cytotoxic phenotype of P. aeruginosa expressing type III secretory toxins and an immunocompromised condition lacking normal Toll-like receptor 4 (TLR4) signaling in the pathogene...

    Authors: Karine Faure, Teiji Sawa, Temitayo Ajayi, Junichi Fujimoto, Kiyoshi Moriyama, Nobuaki Shime and Jeanine P Wiener-Kronish
    Citation: Respiratory Research 2004 5:1
  4. C57BL/6 mice have attenuated allergic airway hyperresponsiveness (AHR) when compared with Balb/c mice but the underlying mechanisms remain unclear. SP-D, an innate immune molecule with potent immunosuppressive...

    Authors: Elena N Atochina, Michael F Beers, Yaniv Tomer, Seth T Scanlon, Scott J Russo, Reynold A Panettieri Jr and Angela Haczku
    Citation: Respiratory Research 2003 4:15
  5. Platelets are thought to play a role in a variety of inflammatory conditions in the lung, some of which may lead to fibrosis. In the current study we tested the hypothesis that whole platelets and platelet lys...

    Authors: Ulrika Zagai, Karin Fredriksson, Stephen I Rennard, Joachim Lundahl and C Magnus Sköld
    Citation: Respiratory Research 2003 4:13
  6. Chronic obstructive pulmonary disease (COPD) is characterized by incompletely reversible airflow obstruction associated with inflammation in which monocytes/macrophages are the predominant inflammatory cells. ...

    Authors: Ruta Aldonyte, Lennart Jansson, Eeva Piitulainen and Sabina Janciauskiene
    Citation: Respiratory Research 2003 4:11
  7. Pollens are important triggers for allergic asthma and seasonal rhinitis, and proteases released by major allergenic pollens can injure airway epithelial cells in vitro. Disruption of mucosal epithelial integrity...

    Authors: Mark J Raftery, Rohit G Saldanha, Carolyn L Geczy and Rakesh K Kumar
    Citation: Respiratory Research 2003 4:10
  8. γδ T cells have an important immunoregulatory and effector function through cytokine release. They are involved in the responses to Gram-negative bacterium and in protection of lung epithelium integrity. On th...

    Authors: Salvador Raga, M Rosa Julià, Catalina Crespí, Joan Figuerola, Natalia Martínez, Joan Milà and Núria Matamoros
    Citation: Respiratory Research 2003 4:9
  9. Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a numbe...

    Authors: Dirk-Jan Slebos, Stefan W Ryter and Augustine MK Choi
    Citation: Respiratory Research 2003 4:7
  10. Genes encoding cytokine mediators are prime candidates for genetic analysis in conditions with T-helper (Th) cell disease driven imbalance. Idiopathic Pulmonary Fibrosis (IPF) is a predominantly Th2 mediated d...

    Authors: Panagiota Latsi, Panagiotis Pantelidis, Dimitris Vassilakis, Hiroe Sato, Kenneth I Welsh and Roland M du Bois
    Citation: Respiratory Research 2003 4:6
  11. Lung morphogenesis is stereotypic, both for lobation and for the first several generations of airways, implying mechanistic control by a well conserved, genetically hardwired developmental program. This progra...

    Authors: David Warburton, Saverio Bellusci, Pierre-Marie Del Moral, Vesa Kaartinen, Matt Lee, Denise Tefft and Wei Shi
    Citation: Respiratory Research 2003 4:5
  12. The link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose rangin...

    Authors: Mark A Birrell, Cliff H Battram, Paul Woodman, Kerryn McCluskie and Maria G Belvisi
    Citation: Respiratory Research 2003 4:2
  13. Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expres...

    Authors: Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine and Joseph B Shrager
    Citation: Respiratory Research 2003 4:3
  14. Chronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α is considered to play a role. In the presen...

    Authors: Mehmet Küçükaycan, Michiel Van Krugten, Herman-Jan Pennings, Tom WJ Huizinga, Wim A Buurman, Mieke A Dentener and Emiel FM Wouters
    Citation: Respiratory Research 2002 3:28
  15. The predictive role of many cytokines and adhesion molecules has not been studied systematically in acute respiratory distress syndrome (ARDS).

    Authors: Panagiotis Agouridakis, Despina Kyriakou, Michael G Alexandrakis, Athanasios Prekates, Kostas Perisinakis, Nikolaos Karkavitsas and Demosthenes Bouros
    Citation: Respiratory Research 2002 3:27
  16. Chronic lung disease (CLD) of prematurity is a major problem of neonatal care. Bacterial infection and inflammatory response have been thought to play an important role in the development of CLD and steroids h...

    Authors: Ying-Hua Li, Zhong-Qun Yan, Annelie Brauner and Kjell Tullus
    Citation: Respiratory Research 2002 3:16
  17. Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared. Additionally, the role of...

    Authors: Susanne Kruse, Sandra Braun and Klaus A Deichmann
    Citation: Respiratory Research 2002 3:17
  18. Neutrophils constitute the first line of defense against invading microorganisms. Whereas these cells readily undergo apoptosis under homeostatic conditions, their survival is prolonged during inflammatory rea...

    Authors: Vasanthi R Sunil, Agnieszka J Connor, Peihong Zhou, Marion K Gordon, Jeffrey D Laskin and Debra L Laskin
    Citation: Respiratory Research 2002 3:14
  19. To demonstrate the involvement of tobacco smoking in the pathophysiology of lung disease, the responses of pulmonary epithelial cells to cigarette smoke condensate (CSC) — the particulate fraction of tobacco s...

    Authors: Gary R Hellermann, Szilvia B Nagy, Xiaoyuan Kong, Richard F Lockey and Shyam S Mohapatra
    Citation: Respiratory Research 2002 3:15
  20. Respiratory syncytial virus (RSV) is the most common viral pathogen that causes lower respiratory tract infections in infants. Studies have implicated severe RSV infections early in life as a risk factor for s...

    Authors: Lone Graff Stensballe
    Citation: Respiratory Research 2002 3(Suppl 1):8

    This article is part of a Supplement: Volume 3 Supplement 1

  21. The incidence, prevalence, and mortality of asthma have increased in children over the past three to four decades, although there has been some decline in the most recent decade. These trends are particularly ...

    Authors: Rosalind L Smyth
    Citation: Respiratory Research 2002 3(Suppl 1):7

    This article is part of a Supplement: Volume 3 Supplement 1

  22. Asthma is a leading cause of morbidity and mortality among children worldwide, as is respiratory syncytial virus (RSV). This report reviews controlled retrospective and prospective studies conducted to investi...

    Authors: Nele Sigurs
    Citation: Respiratory Research 2002 3(Suppl 1):5

    This article is part of a Supplement: Volume 3 Supplement 1

  23. There is substantial epidemiological evidence supporting the concept that respiratory syncytial virus (RSV) lower respiratory tract infection in infancy may be linked to the development of reactive airway dise...

    Authors: Giovanni Piedimonte
    Citation: Respiratory Research 2002 3(Suppl 1):4

    This article is part of a Supplement: Volume 3 Supplement 1

  24. Viral bronchiolitis is the most common cause of hospitalization in infants under 6 months of age, and 70% of all cases of bronchiolitis are caused by respiratory syncytial virus (RSV). Early RSV infection is a...

    Authors: Peter JM Openshaw
    Citation: Respiratory Research 2002 3(Suppl 1):3

    This article is part of a Supplement: Volume 3 Supplement 1

  25. Respiratory syncytial virus (RSV) is the primary cause of hospitalization for acute respiratory tract illness in general and specifically for bronchiolitis in young children. The link between RSV bronchiolitis...

    Authors: Jan LL Kimpen
    Citation: Respiratory Research 2002 3(Suppl 1):2

    This article is part of a Supplement: Volume 3 Supplement 1

  26. Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three pre...

    Authors: Alissa K Greenberg, Herman Yee and William N Rom
    Citation: Respiratory Research 2002 3:13
  27. Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely infla...

    Authors: Gehan Devendra and Roger G Spragg
    Citation: Respiratory Research 2002 3:11
  28. Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (I...

    Authors: Roberto Cruz-Gervis, Arlene A Stecenko, Ryszard Dworski, Kirk B Lane, James E Loyd, Richard Pierson, Gayle King and Kenneth L Brigham
    Citation: Respiratory Research 2002 3:9
  29. The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at...

    Authors: Michael C Iannuzzi, Mary Maliarik and Benjamin Rybicki
    Citation: Respiratory Research 2002 3:7
  30. Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been...

    Authors: Panagiotis Pantelidis, Srihari Veeraraghavan and Roland M du Bois
    Citation: Respiratory Research 2001 3:14
  31. The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease (COPD). COPD is caused by cigarette smoking, evidenced by deterioration in lung function. Lung ...

    Authors: David Hele
    Citation: Respiratory Research 2001 3:12
  32. The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmac...

    Authors: Ian P Hall
    Citation: Respiratory Research 2001 3:10

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