Seow CY, Fredberg JJ: Historical perspective on airway smooth muscle: the saga of a frustrated cell.
J Appl Physiol 2001, 91:938–952.
Black JL, Johnson PR, Armour CL: Factors controlling transduction signaling and proliferation of airway smooth muscle.
Curr Allergy Asthma Rep 2001, 1:116–121.
Black JL, Johnson PR: What determines asthma phenotype? Is it the interaction between allergy and the smooth muscle?
Am J Respir Crit Care Med 2000, 161:S207–10.
Black JL, Johnson PR: Airway smooth muscle in asthma.
Respirology 1996, 1:153–158.
Kelleher MD, Abe MK, Chao T.-S. Oliver, Jain M, Green JM, Solway J, Rosner MR, Hershenson MB: Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Am. J. Physiol. 1995, 268:L894-L901.
Amrani Y, Panettieri RA: Airway smooth muscle: contraction and beyond.
Int J Biochem Cell Biol 2003, 35:272–276.
Holgate ST, Peters-Golden M, Panettieri RA, Henderson W. R., Jr.: Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling.
J Allergy Clin Immunol 2003, 111:S18–34; discussion S34–6.
McParland BE, Macklem PT, Pare PD: Airway wall remodeling: friend or foe?
J Appl Physiol 2003, 95:426–434.
Wang L, McParland BE, Pare PD: The functional consequences of structural changes in the airways: implications for airway hyperresponsiveness in asthma.
Chest 2003, 123:356S-62S.
Homer RJ, Elias JA: Consequences of long-term inflammation. Airway remodeling.
Clin Chest Med 2000, 21:331–43, ix.
Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA: Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
Am J Respir Crit Care Med 2001, 164:S67–70.
James AL, Pare PD, Hogg JC: The mechanics of airway narrowing in asthma.
Am. Rev. Respir. Dis. 1989, 139:242–246.
Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD: Functional significance of increased airway smooth muscle in asthma and COPD.
J. Appl. Physiol. 1993, 74:2771–2781.
Moreno R, Hogg JC, Paré PD: Mechanics of airway narrowing.
Am. Rev. Respir. Dis. 1986, 133:1171–1180.
Paré PD, Wiggs BR, James A, Hogg JC: The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary-disease.
Am. Rev. Respir. Dis. 1991, 143:1189–1193.
Wiggs BR, Bosken C, Paré PD, James A, Hogg JC: A model of airway narrowing in asthma and in chronic obstructive pulmonary disease.
Am. Rev. Respir. Dis. 1992, 145:1251–1258.
Dulin NO, Fernandes DJ, Dowell M, Bellam S, McConville J, Lakser O, Mitchell R, Camoretti-Mercado B, Kogut P, Solway J: What evidence implicates airway smooth muscle in the cause of BHR?
Clin Rev Allergy Immunol 2003, 24:73–84.
Lambert RK, Pare PD: Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness.
J. Appl. Physiol. 1997, 83:140–147.
Macklem PT: Mechanical factors determining maximum bronchoconstriction.
Eur Respir J 1989, 6:516s-519s.
Macklem PT: Bronchial hyperresponsiveness.
Chest 1987, 91:189S-191S.
Macklem PT: A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.
Am. J. Respir. Crit. Care Med. 1996, 153:83–89.
Macklem PT: A hypothesis linking bronchial hyperreactivity and airway inflammation: implications for therapy.
Annals of Allergy 1990, 64:113–116.
Fredberg JJ: Frozen objects: small airways, big breaths, and asthma.
J Allergy Clin Immunol 2000, 106:615–624.
Fredberg JJ, Inouye DS, Mijailovich SM, Butler JP: Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm.
American Journal of Respiratory and Critical Care Medicine 1999, 159:1–9.
Seow CY, Pratusevich VR, Ford LE: Series-to-parallel transition in the filament lattice of airway smooth muscle.
J Appl Physiol 2000, 89:869–876.
Seow CY, Stephens NL: Velocity-length-time relations in canine tracheal smooth muscle.
J Appl Physiol 1988, 64:2053–2057.
Pratusevich Victor R., Seow Chun Y., Ford Lincoln E.: Plasticity in canine airway smooth muscle.
J. Gen. Physiol. 1995, 105:73–94.
Otis AB: A perspective of respiratory mechanics.
J Appl Physiol 1983, 54:1183–1187.
Mead J: Respiration: pulmonary mechanics.
Ann. Rev. Physiol. 1973, 35:169–192.
Colebatch HJH, Olsen CR, Nadel JA: Effect of histamine, serotonin, and acetylcholine on the peripheral airways.
J. Appl. Physiol. 1966, 21:217–226.
Dixon WE, Brodie TG: Contributions to the physiology of the lungs. Part I. The bronchial muscles, their innervation, and the action of drugs upon them.
J. Phyisiol. (London) 1903, 29:97–173.
Salter HH: Classic papers in Asthma: On asthma, its pathology and treatment, 1859.
The Evolution of Understanding
(Edited by: Brewis RAL). London, Science Press Limited 1990, 1:106–142.
Einthoven W: Ueber die Wirkung der Bronchialmuskeln, nach einer neuen Methode untersucht, und ueber Asthma nervosum.
Pfluegers Archives 1892, 51:367–444.
Oldmixon EH, Carlson K, C. Kuhn III, Butler JP, F.G. Hoppin Jr.: Lung contractility: Disposition, quantities and physiological effects of a-actin in rat and guinea pig lungs.
J. Appl. Physiol.
Colebatch HJH, Mitchell CA: Constriction of isolated living liquid-filled dog and cat lungs with histamine.
J. Appl. Physiol. 1971, 30:691–702.
Ludwig MS, Dreshaj I, Solway J, Munoz A, Ingram R H, Jr.: Partitioning of pulmonary resistance during constriction in the dog: effects of volume history.
J. Appl. Physiol. 1987, 62:807–815.
Ludwig M, Shore S, Fredberg JJ, Drazen JM: Differential responses of tissue viscance and collateral resistance to histamine and leukotriene C4.
J. Appl. Physiol. 1988, 65:1424–1429.
Fredberg JJ, Bunk D, Ingenito E, Shore SA: Tissue resistance and the contractile state of lung parenchyma.
J. Appl. Physiol. 1993, 74:1387–1397.
Dolhnikoff M, Morin J, Ludwig MS: Human lung parenchyma responds to contractile stimulation.
Am J Respir Crit Care Med 1998, 158:1607–1612.
Yager D, Butler JP, Bastacky J, Israel E, Smith G, Drazen JM: Amplification of airway constriction due to liquid filling of airway interstices.
J. Appl. Physiol. 1989, 66:2873–2884.
Woolcock AJ, Peat JK: Epidemiology of bronchial hyperresponsiveness.
Clin Rev Allergy 1989, 7:245–256.
Sterk PJ, Bel EH: Bronchial hyperresponsiveness: the need to distinguish between hypersensitivity and excessive airway narrowing.
Eur. Respir. J. 1989, 2:267–274.
Armour CL, Black JL, Berend N, Woolcock AJ: The relationship between bronchial hyperresponsiveness to methacholine and airway smooth muscle structure and reactivity.
Respir Physiol 1984, 58:223–233.
Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000, 356:2144–2148.
Bryan SA, O'Connor BJ, Matti S, Leckie MJ, Kanabar V, Khan J, Warrington SJ, Renzetti L, Rames A, Bock JA, Boyce MJ, Hansel TT, Holgate ST, Barnes PJ: Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000, 356:2149–2153.
Crimi E, Spanevello A, Neri M, Ind PW, Rossi GA, Brusasco V: Dissociation between airway inflammation and aiway hyperresponsiveness in allergic asthma.
Am. J. Respir. Crit. Care Med. 1998, 157:4–9.
Holloway JW, Beghe B, Holgate ST: The genetic basis of atopic asthma.
Clin Exp Allergy 1999, 29:1023–1032.
Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway J: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
J Appl Physiol 2003, 95:844–853.
Wang L, Paré PD, Seow CY: Effect of chronic passive length change on airway smooth muscle length-tension relationship.
J Appl Physiol 2001, 90:734–740.
Lakser OJ, Lindeman RP, Fredberg JJ: Inhibition of the p38 MAP kinase pathway destabilizes smooth muscle length during physiological loading.
Am J Physiol Lung Cell Mol Physiol 2002, 282:L1117–21.
Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM: Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.
Am J Respir Cell Mol Biol 2003, 28:142–149.
Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, Drazen JM: Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.
Am J Physiol Lung Cell Mol Physiol 2002, 282:L904–11.
Shore SA, Laporte J, Hall IP, Hardy E, Panettieri Jr RA: Effect of IL-1beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists.
Am J Respir Cell Mol Biol 1997, 16:702–712.
Halayko AJ, Solway J: Molecular mechanisms of phenotypic plasticity in smooth muscle cells.
J Appl Physiol 2001, 90:358–368.
Halayko AJ, Morla A, Camoretti-Mercado B, Forsythe S, Vieira JE, Niu Q, Shapiro S, Hershenson MB, Stephens NL, Solway J: Contractile phenotype expession by cultured canine airway myocytes is inhibited by poly-L-lysine and by fibronectin matrix disassembly.
Am. J. Resp. Crit. Care. Med. 1998, A656.
Small JV: Structure-function relationships in smooth muscle: the missing links.
Bioessays 1995, 17:785–792.
Small JV, Gimona M: The cytoskeleton of the vertebrate smooth muscle cell.
Acta Physiol Scand 1998, 164:341–348.
Huxley AF: Muscle structure and theories of contraction.
Prog in Biophys Biophys Chem 1957, 7:255–318.
Murphy RA: What is special about smooth muscle? The significance of covalent crossbridge regulation.
FASEB J 1994, 8:311–318.
Murphy RA: Muscle cells of hollow organs.
News in Physiological Sciences 1988, 3:124–128.
Mijailovich SM, Butler JP, Fredberg JJ: Perturbed equilibria of myosin binding in airway smooth muscle: bond- length distributions, mechanics, and ATP metabolism.
Biophys J 2000, 79:2667–2681.
Uvelius B: Isometric and isotonic length-tension relations and variations in cell length in longitudinal smooth muscle from rabbit urinary bladder.
Acta Physiol Scand 1976, 97:1–12.
Stephens NL, Laviolette M, Unruh H, Ma X: Contractility in bronchial airway smooth muscle cells obtained from asthmatic subjects by endobronchial biopsy is increased.
American Journal of Respiratory and Critical Care Medicine 1998, 157:A746.
Stephens NL: Airway smooth muscle.
Am. Rev. Respir. Dis. 1987, 135:960–975.
Stephens Newman L., Seow Chun Y.: Airway smooth muscle: Physiology, Bronchomotor Tone, Pharmacology, and relation to Asthma.
(Edited by: EB Weiss et al). 1993.
Xu JQ, Harder BA, Uman P, Craig R: Myosin filament structure in vertebrate smooth muscle.
J Cell Biol 1996, 134:53–66.
Tonino P, Simon M, Craig R: Mass determination of native smooth muscle myosin filaments by scanning transmission electron microscopy.
J Mol Biol 2002, 318:999–1007.
Mehta D, Wu M-F, Gunst SJ: Role of contractile protein activation in the length-dependent modulation of tracheal smooth muscle force.
Am. J. Physiol. 1996, 270:C243-C252.
Hai CM: Length-dependent myosin phosphorylation and contraction of arterial smooth muscle.
Pflugers Arch 1991, 418:564–571.
Gunst SJ, Meiss RA, Wu Ming-Fang, Rowe M: Mechanisms for the mechanical placticity of tracheal smooth muscle.
Am. J. Physiol. 1995, 268:C1267-C1276.
Stephens NL, Kromer U: Series elastic component of tracheal smooth muscle.
Am. J. Physiol. 1971, 220:1890–1895.
Warshaw DM, Rees DD, Fay FS: Characterization of cross-bridge elasticity and kinetics of cross-bridge cycling force development in single smooth muscle cells.
J. Gen. Physiol. 1988, 91:761–779.
Nagase T, Moretto A, Ludwig MS: Airway and tissue behavior during induced constriction in rats: intravenous vs. aerosol administration.
J Appl Physiol 1994, 76:830–838.
Romero P, Ludwig MS: Maximal methacholine-induced constriction in rabbit lungs: interactions between airways and tissues?
J. Appl. Physiol. 1991, 70:1044–1050.
Ding DJ, Martin JG, Macklem PT: Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans.
Journal of Applied Physiology 1987, 62:1324–1330.
Robatto FM, Simard S, Orana H, Macklem PT, Ludwig MS: Effect of lung volume on plateau response of airways and tissue to methacholine in dogs.
J. Appl. Physiol. 1992, 73:1908–1913.
Wiggs BR, Hrousis CA, Drazen JM, Kamm RD: On the mechanism of mucosal folding in normal and asthmatic airways.
J. Appl. Physiol. 1997, 83:1814–1821.
Meiss RA: Influence of intercellular tissue connections on airway muscle mechanics.
J Appl Physiol 1999, 86:5–15.
Brown RH, Mitzner W: The myth of maximal airway responsiveness in vivo.
J Appl Physiol 1998, 85:2012–2017.
Warner David O., Gunst Susan J.: Limitation of maximal bronchoconstriction in living dogs.
American Review of Respiratory Disease 1992, 145:553–560.
Moore BJ, King GG, D'Yachkova Y, Ahmad HR, Pare PD: Mechanism of methacholine dose-response plateaus in normal subjects.
Am. J. Respir. Crit. Care Med. 1998, 158:666–669.
Moore BJ, Verburgt LM, King GG, Pare PD: Effect of deep inspiration on methacholine dose-response curves in normal subjects.
Am. J. Respir. Crit. Care Med. 1997, 156:1278–1281.
Fredberg JJ, Shore SA: The unbearable lightness of breathing.
J Appl Physiol 1999, 86:3–4.
Fish JE, Ankin MG, Kelly JF, Peterman VI: Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects.
Journal of Applied Physiology 1981, 50:1079–1086.
Nadel Jay A., Tierney Donald F.: Effect of a previous deep inspiration on airway resistance in man.
Journal of Applied Physiology 1961, 16:717–719.
Lim TK, Pride NB, Ingram Jr. RH: Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma.
Am. Rev. Respir. Dis. 1987, 135:591–596.
Skloot Gwen, Permutt Solbert, Togias Alkis: Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration.
Journal of Clinical Investigation 1995, 96:2393–2403.
Solway J, Fredberg JJ: Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness afer all.
Am. J. Resp.Cell. Mol. Biol. 1997, 17:144–146.
Antonissen LA, Mitchell RW, Kroeger EA, Krepon W, Tse KS, Stephens NL: Mechanical alterations of airway smooth muscle in a canine asthmatic model.
J. Appl. Physiol. 1979, 46:681–687.
Fan T, Yang M, Halayko A, Mohapatra SS, Stephens NL: Airway responsiveness in two inbred strains of mouse disparate in IgE and IL-4 production.
Am. J. Respir. Cell. Mol. Biol. 1997, 17:156–163.
Jiang H, Rao K, Halayko AJ, Liu X, Stephens NL: Ragweed sensitization-induced increase of myosin light chain kinase content in canine airway smooth muscle.
Am J Respir Cell Mol Biol 1992, 7:567–573.
Thomson RJ, Bramley AM, Schellenberg RR: Airway muscle stereology: implications for increased shortening in asthma.
Am. J. Respir. Crit. Care. Med. 1996, 154:749–757.
Fredberg JJ: Airway smooth muscle in asthma. Perturbed equilibria of myosin binding.
Am J Respir Crit Care Med 2000, 161:S158–60.
Fredberg JJ: Airway smooth muscle in asthma: flirting with disaster.
Eur Respir J 1998, 12:1252–1256.
Duguet A, Biyah K, Minshall E, Gomes R, Wang CG, Taoudi-Benchekroun M, Bates JH, Eidelman DH: Bronchial responsiveness among inbred mouse strains. Role of airway smooth-muscle shortening velocity.
Am J Respir Crit Care Med 2000, 161:839–848.
Wang CG, Almirall JJ, Dolman CS, Dandurand RJ, Eidelman DH: In vitro bronchial responsiveness in two highly inbred rat strains.
J. Appl. Physiol. 1997, 82:1445–1452.
Ma X, Cheng Z, Kong H, Wang Y, Unruh H, Stephens NL, Laviolette M: Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects.
Am J Physiol Lung Cell Mol Physiol 2002, 283:L1181–9.
Fredberg JJ, Inouye D, Miller B, Nathan M, Jafari S, Raboudi SH, Butler JP, Shore SA: Airway smooth muscle, tidal stretches, and dynamically determined contractile states.
Am. J. Respir. Crit. Care. Med. 1997, 156:1752–1759.
Gump A, Haughney L, Fredberg J: Relaxation of activated airway smooth muscle: relative potency of isoproterenol vs. tidal stretch.
J Appl Physiol 2001, 90:2306–2310.
Shen X, Gunst SJ, Tepper RS: Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits.
J. Appl. Physiol. 1997, 83:1202–1208.
Lauzon AM, Tyska MJ, Rovner AS, Freyzon Y, Warshaw DM, Trybus KM: A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap.
J Muscle Res Cell Motil 1998, 19:825–837.
Murphy RA, Walker JS, Strauss JD: Myosin isoforms and functional diversity in vertebrate smooth muscle.
Comp Biochem Physiol 1997, 117:51–60.
Dillon PF, Aksoy MO, Driska SP, Murphy RA: Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle.
Science 1981, 211:495–497.
Barany Michael: ATPase activity of myosin correlated with speed of muscle shortening.
Journal of General Physiology 1967, 50:197–218.
Fredberg JJ, Jones KA, Nathan M, Raboudi S, Prakash YS, Shore SA, Butler JP, Sieck GC: Friction in airway smooth muscle: mechanism, latch and implications in asthma.
J. Appl. Physiol. 1996, 81:2703–2712.
Hai CM, Murphy RA: Cross-bridge dephosphorylation and relaxation of vascular smooth muscle.
Am. J. Physiol. 1989, 256:C282-C287.
Butler TM, Siegman MJ: Control of cross-bridge cycling by myosin light chain phosphorylation in mammalian smooth muscle.
Acta Physiol Scand 1998, 164:389–400.
Haeberle JR, Hemric ME: A model for the coregulation of smooth muscle actomyosin by caldesmon, calponin, tropomyosin, and the myosin regulatory light chain.
Can J Physiol Pharmacol 1994, 72:1400–1409.
Jones KA, Lorenz RR, Prakash YS, Sieck GC, Warner DO: ATP hydrolysis during contraction of permeabilized airway smooth muscle [In Process Citation].
Am J Physiol 1999, 277:L334–42.
Horowitz A, Menice CB, Laporte R, Morgan KG: Mechanisms of smooth muscle contraction.
Physiol. Rev. 1996, 76:967–1003.
Sanders LC, Matsumura F, Bokoch GM, de Lanerolle P: Inhibition of myosin light chain kinase by p21-activated kinase [see comments].
Science 1999, 283:2083–2085.
Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K: Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho- kinase) [see comments].
Science 1996, 273:245–248.
Weber LP, Van Lierop JE, Walsh MP: Ca2+-independent phosphorylation of myosin in rat caudal artery and chicken gizzard myofilaments.
J Physiol (Lond) 1999, 516:805–824.
Hai CM, Murphy RA: Cross-bridge phosphorylation and regulation of latch state in smooth muscle.
Am. J. Physiol. 1988, 254:C99-C106.
Hai CM, Murphy RA: Regulation of shortening velocity by cross-bridge phosphorylation in smooth muscle.
Am. J. Physiol. 1988, 255:C86-C94.
Hai CM, Murphy RA: CA2+, crossbridge, phosphorylation, and contraction.
Annu. Rev. Physiol. 1989, 51:285–298.
Haeberle JR, Trybus KM, Hemric ME, Warshaw DM: The effects of smooth muscle caldesmon on actin filament motility.
J. Biol. Chem. 1992, 267:23001–23006.
Gerthoffer WT, Pohl J: Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction.
Can J Physiol Pharmacol 1994, 72:1410–1414.
Huang R, Li L, Guo H, Wang CL: Caldesmon binding to actin is regulated by calmodulin and phosphorylation via different mechanisms.
Biochemistry 2003, 42:2513–2523.
Gunst Susan J., Stropp John Q., Service Jennifer: Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro.
Journal of Applied Physiology 1990, 68:2223–2229.
Gunst SJ: Contractile force of airway smooth muscle during cyclical length changes.
J Appl Physiol 1983, 55:759–769.
Gunst SJ: Effect of length history on contractile behavior of canine tracheal smooth muscle.
Am. J. Physiol. 1986, 250:C146-C154.
Sasaki H, Hoppin FG Jr: Hysteresis of contracted airway smooth muscle.
J Appl Physiol 1979, 47:1251–1262.
Molfino NA, Slutsky AS, Julia-Serda G, Hoffstein V, Szalai JP, Chapman KR, Rebuk AS, Zamel N: Assessment of airway tone in asthma.
Am. Rev. Respir. Dis. 1993, 148:1238–1243.
Lim TK, Ang SM, Rossing TH, Ingenito EP, Ingram Jr. RH: The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes.
Am. Rev. Respir. Dis. 1989, 140:340–343.
Wheatley JR, Pare PD, Engel LA: Reversibility of induced bronchoconstriction by deep inspiration in asthmatic and normal subjects.
Eur. Respir. J. 1989, 2:331–339.
Kapsali T, Permutt S, Laube B, Scichilone N, Togias A: Potent bronchoprotective effect of deep inspiration and its absence in asthma.
J Appl Physiol 2000, 89:711–720.
Malmberg P, Larsson K, Sundblad BM, Zhiping W: Importance of time interval between FEV1 measurements in a methacholine provocation test.
Eur. Respir. J. 1993, 6:680–686.
Scichilone N, Kapsali T, Permutt S, Togias A: Deep inspiration-induced bronchoprotection is stronger than bronchodilation.
Am J Respir Crit Care Med 2000, 162:910–916.
Scichilone N, Permutt S, Togias A: The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness.
Am J Respir Crit Care Med 2001, 163:413–419.
Scichilone N, Pyrgos G, Kapsali T, Anderlind C, Brown R, Permutt S, Togias A: Airways hyperresponsiveness and the effects of lung inflation.
Int Arch Allergy Immunol 2001, 124:262–266.
Pare PD, Roberts CR, Bai TR, Wiggs BJ: The functional consequences of airway remodeling in asthma.
Monaldi Arch Chest Dis 1997, 52:589–596.
Moreno RH, Lisboa C, Hogg JC, Paré PD: Limitation of airway smooth muscle shortening by cartilage stiffness and lung elastic recoil in rabbits.
J. Appl. Physiol. 1993, 75:738–744.
Irvin CG: Lung volume: a principle determinant of airway smooth muscle function.
Eur Respir J 2003, 22:3–5.
McClean MA, Matheson MJ, McKay K, Johnson PR, Rynell AC, Ammit AJ, Black JL, Berend N: Low lung volume alters contractile properties of airway smooth muscle in sheep.
Eur Respir J 2003, 22:50–56.
Colebatch HJ, Finucane KE, Smith MM: Pulmonary conductance and elastic recoil relationships in asthma and emphysema.
J Appl Physiol 1973, 34:143–153.
Brown RH, Herold CJ, Hirshman CA, Zerhouni EA, Mitzner W: Individual airway constrictor response heterogeneity to histamine assessed by high-resolution computed tomography.
J. Appl. Physiol. 1993, 74:2615–2620.
Fredberg JJ, Ingram R H Jr., Castile RG, Glass GM, Drazen JM: Nonhomogeneity of lung response to inhaled histamine assessed with alveolar capsules.
J. Appl. Physiol. 1985, 58:1914–1922.
Hubmayr RD, Hill MJ, Wilson TA: Nonuniform expansion of constricted dog lungs.
J Appl Physiol 1996, 80:522–530.
Ludwig M, Bellofiore S, Powell WS, Martin JG: Regional variability in the collateral resistance response to histamine in the dog: effects of cyclooxygenase inhibition.
Respiration Physiology 1989, 78:297–308.
Lutchen KR, Gillis H: Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance.
J Appl Physiol 1997, 83:1192–1201.
Tepper RS, Shen X, Bakan E, Gunst SJ: Maximal airway responses in mature and immature rabbits during tidal ventilation.
J. Appl. Physiol. 1995, 79:1190–1198.
Otis D. R., Jr., Petak F, Hantos Z, Fredberg JJ, Kamm RD: Airway closure and reopening assessed by the alveolar capsule oscillation technique.
J Appl Physiol 1996, 80:2077–2084.
Suki B, Barabasi AL, Hantos Z, Petak F, Stanley HE: Avalanches and power-law behaviour in lung inflation.
Nature 1994, 368:615–618.
Minshall E, Wang CG, Dandurand R, Eidelman D: Heterogeneity of responsiveness of individual airways in cultured lung explants.
Can J Physiol Pharmacol 1997, 75:911–916.
Anafi RC, Wilson TA: Airway stability and heterogeneity in the constricted lung.
J Appl Physiol 2001, 91:1185–1192.
Anafi RC, Beck KC, Wilson TA: Impedance, gas mixing, and bimodal ventilation in constricted lungs.
J Appl Physiol 2003, 94:1003–1011.
Macklem PT: Airway obstruction and collateral ventilation.
Physiol Rev 1971, 51:368–436.
Jensen A, Atileh H, Suki B, Ingenito EP, Lutchen KR: Selected contribution: Airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations.
J Appl Physiol 2001, 91:506–515.
Brown RH, Mitzner W: Understanding airway pathophysiology with computed tomograpy.
J Appl Physiol 2003, 95:854–862.
Mijailovich SM: Dynamics of airway closure: critical smooth muscle activation in normals and asthmatics.
Am. J. Respir. Crit. Care Med. 2003, 167:A183.
Ikeda K, Mitchell RW, Guest KA, Seow CY, Kirchoff CF, Murphy TM, Leff AR: Ontogeny of shortening velocity in porcine trachealis.
A J Physiol 1992, L280-M625.
Murphy TM, Mitchell RW, Halayko A, Roach J, Roy L, Kelly EA, Munoz NM, Stephens NL, Leff AR: Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction.
Am J Physiol 1991, 260:L471–80.
Chitano P, Cox CM, Murphy TM: Relaxation of guinea pig trachealis during electrical field stimulation increases with age.
J Appl Physiol 2002, 92:1835–1842.
Chitano P, Wang J, Cox CM, Stephens NL, Murphy TM: Different ontogeny of rate of force generation and shortening velocity in guinea pig trachealis.
J Appl Physiol 2000, 88:1338–1345.
Mitchell RW, Murphy TM, Leff AR: Physiological mechanisms mediating enhanced force generation during development and immune sensitization.
Can J Physiol Pharmacol 1992, 70:615–623.
Eden E, Mitchell D, Mehlman B, Khouli H, Nejat M, Grieco MH, Turino GM: Atopy, asthma and emphysema in patients with severe alpha-1-antitrypsin deficiency.
Am. J. Respir. Crit. Care Med. 1997, 156:68–74.
Singas E, Lesser M, Spungen AM, Bauman WA, Almenoff PL: Airway hyperresponsiveness to methacholine in subjects with spinal cord injury.
Chest 1996, 110:911–915.
Sparrow D, O'Connor GT, Rosner B, Weiss ST: Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study.
Am J Respir Crit Care Med 1994, 149:376–381.
Boyer J, Amin N, Taddonio R, Dozor AJ: Evidence of airway obstruction in children with idiopathic scoliosis.
Chest 1996, 109:1532–1535.
Camargo C. A., Jr., Weiss ST, Zhang S, Willett WC, Speizer FE: Prospective study of body mass index, weight change, and risk of adult-onset asthma in women [see comments].
Arch Intern Med 1999, 159:2582–2588.
Sampson MG, Grassino AE: Load compensation in obese patients during quiet tidal breathing.
J Appl Physiol 1983, 55:1269–1276.
Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA: Responses to ozone are increased in obese mice.
J Appl Physiol 2003, 95:938–945.
Martin RJ: Nocturnal Asthma. Mount Kisco, Futura Publishing Co. 1993.
Martin RJ, Pak J, Irvin CG: Effect of lung volume maintenance during sleep in nocturnal asthma.
J Appl Physiol 1993, 75:1467–1470.
Schatz M, Dombrowski MP, Wise R, Thom EA, Landon M, Mabie W, Newman RB, Hauth JC, Lindheimer M, Caritis SN, Leveno KJ, Meis P, Miodovnik M, Wapner RJ, Paul RH, Varner MW, O'Sullivan M J, Thurnau GR, Conway D, McNellis D: Asthma morbidity during pregnancy can be predicted by severity classification.
J Allergy Clin Immunol 2003, 112:283–288.
Kelsen SG: Asthma and pregnancy.
J Allergy Clin Immunol 2003, 112:268–270.
Gilroy RJ, Mangura BT, Lavietes MH: Rib cage and abdominal volume displacements during breathing in pregnancy.
Am Rev Respir Dis 1988, 137:668–672.
Gilroy R. J., Jr., Lavietes MH, Loring SH, Mangura BT, Mead J: Respiratory mechanical effects of abdominal distension.
J Appl Physiol 1985, 58:1997–2003.
Haley KJ, Drazen JM: Inflammation and airway function in asthma - What you see is not necessarily what you get.
Am. J. Respir. Crit. Care Med. 1998, 157:1–3.
Gunst SJ, Wu MF: Plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms.
J Appl Physiol 2001, 90:741–749.
Gunst SJ, Wu MF, Smith DD: Contraction history modulates isotonic shortening velocity in smooth muscle.
Am. J. Physiol. 1993, 265:C467-C476.
Kuo KH, Herrera AM, Wang L, Pare PD, Ford LE, Stephens NL, Seow CY: Structure-function correlation in airway smooth muscle adapted to different lengths.
Am J Physiol Cell Physiol 2003, 285:C384–90.
Kuo KH, Wang L, Pare PD, Ford LE, Seow CY: Myosin thick filament lability induced by mechanical strain in airway smooth muscle.
J Appl Physiol 2001, 90:1811.
Ford LE, Seow CY, Pratusevich VR: Plasticity in smooth muscle, a hypothesis.
Can J Physiol Pharmacol 1994, 72:1320–1324.
Naghshin J, Wang L, Pare PD, Seow CY: Adaptation to chronic length change in explanted airway smooth muscle.
J Appl Physiol 2003, 95:448–53; discussion 435.
Qi D, Mitchell RW, Burdyga T, Ford LE, Kuo KH, Seow CY: Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation.
Am J Physiol Cell Physiol 2002, 282:C1298–305.
Wang L, Paré PD, Seow CY: Effect of length oscillation on the subsequent force development in swine tracheal smooth muscle.
J Appl Physiol 2000, 88:2246–2250.
Hirshman CA, Emala CW: Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho.
Am J Physiol 1999, 277:L653–61.
An SS, Laudadio RE, Lai J, Rogers RA, Fredberg JJ: Stiffness changes in cultured airway smooth muscle cells.
Am J Physiol Cell Physiol 2002, 283:C792–801.
Wang P, Bitar KN: Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27.
Am J Physiol 1998, 275:G1454–62.
Mehta D, Tang DD, Wu MF, Atkinson S, Gunst SJ: Role of Rho in Ca(2+)-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle.
Am J Physiol Cell Physiol 2000, 279:C308–18.
Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT: p38 mitogen-activated protein kinase expression and activation in smooth muscle.
Am J Physiol 1998, 275:C527–34.
Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA, Gerthoffer WT: A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration.
J Biol Chem 1999, 274:24211–24219.
Hedges JC, Oxhorn BC, Carty M, Adam LP, Yamboliev IA, Gerthoffer WT: Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.
Am J Physiol Cell Physiol 2000, 278:C718–26.
Yamboliev IA, Hedges JC, Mutnick JL, Adam LP, Gerthoffer WT: Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway.
Am J Physiol Heart Circ Physiol 2000, 278:H1899–907.
An S, Fabry B, Mellema M, Bursac P, Gerthoffer WT, Kayyali US, Gaestal M, Shore SA, Fredberg JJ: Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell.
J Applied Physiol, in press.
Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Taback NA, Millet EJ, Fredberg JJ: Time scale and other invariants of integrative mechanical behavior in living cells.
Phys Rev E Stat Nonlin Soft Matter Phys 2003, 68:41914.
Gunst SJ, Fredberg JJ: The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses.
J Appl Physiol 2003, 95:413–425.
Fabry B, Fredberg JJ: Remodeling of the airway smooth muscle cell: are we built of glass?
Respir Physiol Neurobiol 2003, 137:109–124.