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  1. The complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major complementary defense mechanism against pathogens, continuously emergi...

    Authors: M. G. Detsika, K. Palamaris, I. Dimopoulou, A. Kotanidou and S. E. Orfanos
    Citation: Respiratory Research 2024 25:20
  2. Spontaneous intracerebral hemorrhage (ICH) is a condition associated with high mortality and morbidity. Survivors may require prolonged intubation with mechanical ventilation (MV). The aim of this study was to...

    Authors: Ue-Cheung Ho, Chia-Jung Hsieh, Hsueh-Yi Lu, Abel Po-Hao Huang and Lu-Ting Kuo
    Citation: Respiratory Research 2024 25:19
  3. Aging is associated with an increased incidence and mortality of Pseudomonas aeruginosa-induced pneumonias. This might be partly due to age-dependent increases in inflammatory mediators, referred to as inflamm-ag...

    Authors: Charline Sommer, Stella Marie Reamon-Buettner, Monika Niehof, Christina Beatrix Hildebrand, Armin Braun, Katherina Sewald, Susann Dehmel and Christina Brandenberger
    Citation: Respiratory Research 2024 25:15
  4. Ambient fine particulate matter (PM2.5) is considered a plausible contributor to the onset of chronic obstructive pulmonary disease (COPD). Mechanistic studies are needed to augment t...

    Authors: Zhang-fu Fang, Zhao-ni Wang, Zhe Chen, Yang Peng, Yu Fu, Yang Yang, Hai-long Han, Yan-bo Teng, Wei Zhou, Damo Xu, Xiao-yu Liu, Jia-xing Xie, Junfeng (Jim) Zhang and Nan-shan Zhong
    Citation: Respiratory Research 2024 25:14
  5. Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has be...

    Authors: Gustav Wall-Gremstrup, Rune Holt, Sam Kafai Yahyavi, Mads Joon Jorsal, Anders Juul, Niels Jørgensen and Martin Blomberg Jensen
    Citation: Respiratory Research 2024 25:11
  6. Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with more than 200 entities and relevant differences in disease course and prognosis. Little data is available on...

    Authors: Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr…
    Citation: Respiratory Research 2024 25:5
  7. Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such ...

    Authors: Michelle Brand, Felix Ritzmann, Kathrin Kattler, Deivydas Milasius, Yiwen Yao, Christian Herr, Susanne H. Kirsch, Rolf Müller, Daniela Yildiz, Robert Bals and Christoph Beisswenger
    Citation: Respiratory Research 2024 25:3
  8. Accurately distinguishing between pulmonary infection and colonization in patients with Acinetobacter baumannii is of utmost importance to optimize treatment and prevent antibiotic abuse or inadequate therapy. An...

    Authors: Zhaodong Zeng, Jiefang Wu, Genggeng Qin, Dong Yu, Zilong He, Weixiong Zeng, Hao Zhou, Jiongbin Lin, Laiyu Liu, Chunxia Qi and Weiguo Chen
    Citation: Respiratory Research 2024 25:2
  9. The Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and edema, impairing both oxygenation and lung compliance. Recent studies reported a dissociation between oxygenation and co...

    Authors: Eleni Papoutsi, Ioannis Andrianopoulos, Vasiliki Mavrikaki, Maria Bolaki, Vagia Stamatopoulou, Eleni Toli, Georgios Papathanakos, Vasilios Koulouras, Eumorfia Kondili, Ilias I. Siempos and Katerina Vaporidi
    Citation: Respiratory Research 2024 25:1
  10. Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease (ILD) associated with smoking, whose definitive diagnosis requires the exclusion of other forms of ILD and a compatible surgic...

    Authors: Silvia Barril, Paloma Acebo, Paloma Millan-Billi, Alfonso Luque, Oriol Sibila, Carlos Tarín, Abdellatif Tazi, Diego Castillo and Sonsoles Hortelano
    Citation: Respiratory Research 2023 24:320
  11. Mitochondrial dysfunction and lung cellular senescence are significant features involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) stands as the primary contribu...

    Authors: Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang and Feng Li
    Citation: Respiratory Research 2023 24:319
  12. Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, ...

    Authors: Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li, Ivan Rosas, Lan Wang and Guoying Yu
    Citation: Respiratory Research 2023 24:318
  13. Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in the airways and subsequent respiratory infection. The recently approved triple therapy Elexacaftor–Tezacaftor–Ivacaftor (ETI) ha...

    Authors: Christian Martin, Douglas V. Guzior, Cely T. Gonzalez, Maxwell Okros, Jenna Mielke, Lienwil Padillo, Gabriel Querido, Marissa Gil, Ryan Thomas, Marc McClelland, Doug Conrad, Stefanie Widder and Robert A. Quinn
    Citation: Respiratory Research 2023 24:317
  14. Over the last ten years an increasing prevalence and incidence of non-tuberculous mycobacteria (NTM) has been reported among patients with cystic fibrosis (CF) Viviani (J Cyst Fibros, 15(5):619–623, 2016). NTM...

    Authors: Andrea Gramegna, Sofia Misuraca, Andrea Lombardi, Chiara Premuda, Ivan Barone, Margherita Ori, Francesco Amati, Mariangela Retucci, Erica Nazzari, Gianfranco Alicandro, Maurizio Ferrarese, Luigi Codecasa, Alessandra Bandera, Stefano Aliberti, Valeria Daccò and Francesco Blasi
    Citation: Respiratory Research 2023 24:316
  15. The two-way communications along the gut-lung axis influence the immune function in both gut and lung. However, the shared genetic characteristics of lung function with gastrointestinal tract (GIT) diseases re...

    Authors: Minghui Jiang, Xingjie Hao, Yi Jiang, Si Li, Chaolong Wang and Shanshan Cheng
    Citation: Respiratory Research 2023 24:315
  16. Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibr...

    Authors: Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson and Kevin K. Kim
    Citation: Respiratory Research 2023 24:314
  17. Sporadic studies have examined the impact of OSA on ACS patients by homocysteine (Hcy) level. This study attempted to comprehensively evaluate the effects of the interaction between Hcy and OSA on long-term ca...

    Authors: Xiuhuan Chen, Lei Zhen, Hui Ai, Bin Que, Jingyao Fan, Xiao Wang, Yan Yan, Siyi Li, Zekun Zhang, Yun Zhou, Wei Gong and Shaoping Nie
    Citation: Respiratory Research 2023 24:313
  18. Severe asthma and COPD exacerbations requiring hospitalization are linked to increased disease morbidity and healthcare costs. We sought to identify Electronic Health Record (EHR) features of severe asthma and...

    Authors: Kevin Lopez, Huan Li, Zachary Lipkin-Moore, Shannon Kay, Haseena Rajeevan, J. Lucian Davis, F. Perry Wilson, Carolyn L. Rochester and Jose L. Gomez
    Citation: Respiratory Research 2023 24:311
  19. Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. A large number of studies have shown that pulmonary vascular...

    Authors: Lei Ma, Yanxia Wang, Xiaoqian Li, Zefang Wang, Bo Zhang, Ying Luo, Yousheng Wu, Zhichao Li and Wen Niu
    Citation: Respiratory Research 2023 24:310
  20. Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease. α-defensins are ...

    Authors: Jungnam Lee, Naweed Mohammad, Yuanqing Lu, Regina Oshins, Alek Aranyos and Mark Brantly
    Citation: Respiratory Research 2023 24:309
  21. Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signal...

    Authors: Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman…
    Citation: Respiratory Research 2023 24:308
  22. Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates. Although lung transplantation is a life-saving treatment for selected patients with IL...

    Authors: Hyeon Hwa Kim, Ho Cheol Kim, Tae Sun Shim, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Geun Dong Lee, Dong Kwan Kim, Seung-Il Park and Sehoon Choi
    Citation: Respiratory Research 2023 24:307
  23. Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious respiratory diseases such as influenza. Our previous studies have shown tha...

    Authors: Shunwang Li, Xiangwu Ju, Qiang Liu, Yiwu Yan, Cong Zhang, Yuhao Qin, Xingyu Deng, Chang Li, Mingyao Tian, Yanli Zhang, Ningyi Jin and Chengyu Jiang
    Citation: Respiratory Research 2023 24:306
  24. Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizuma...

    Authors: Ayobami Akenroye, Tanawin Nopsopon, Laura Cho, Matthew Moll and Scott T. Weiss
    Citation: Respiratory Research 2023 24:305
  25. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical out...

    Authors: Anlin Feng, Yesenia Moreno Caro, Colin Gardner, Garrett Grischo, Ying Liang, Praveen D. Wickremasinghe, Michaela Polmann, Mrinalini Kala, Timothy Marlowe, Stephen M. Black, Kenneth S. Knox and Ting Wang
    Citation: Respiratory Research 2023 24:304
  26. Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immun...

    Authors: Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro and Peter G. Gibson
    Citation: Respiratory Research 2023 24:303
  27. Air pollution, weather, pollen, and influenza are typical aggravating factors for asthma. Previous studies have identified risk factors using regression-based and ensemble models. However, studies that conside...

    Authors: Hyemin Hwang, Jae-Hyuk Jang, Eunyoung Lee, Hae-Sim Park and Jae Young Lee
    Citation: Respiratory Research 2023 24:302
  28. It is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke extract (CSE). However, the mechanisms underlying th...

    Authors: Congping Li, Fei Chen, Liangfen Lin, Jiwei Li, Yamei Zheng and Qingyun Chen
    Citation: Respiratory Research 2023 24:301
  29. The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of lung-resident mesenchymal stem cells (LR-MSCs) has been identified as a critical sourc...

    Authors: Yi Lu, Zeyu Liu, Yunjiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang and Tao Ren
    Citation: Respiratory Research 2023 24:300
  30. Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM fro...

    Authors: Bin Chen, Ziyi Liu, Jinjuan Lu, Zhihao Li, Kaiming Kuang, Jiancheng Yang, Zengmao Wang, Yingli Sun, Bo Du, Lin Qi and Ming Li
    Citation: Respiratory Research 2023 24:299
  31. IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled fibrosis. Fibroblasts and t...

    Authors: Fama Thiam, Sakshi Phogat, Filsan Ahmed Abokor and Emmanuel Twumasi Osei
    Citation: Respiratory Research 2023 24:298
  32. Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung disease, is a leading cause of morbidity and mortality worldwide. Prolonged cigarette smoking (CS) that causes irreversible airway remo...

    Authors: Wensi Zhu, Linxiao Han, Yuanyuan Wu, Lin Tong, Ludan He, Qin Wang, Yu Yan, Ting Pan, Jie Shen, Yuanlin Song, Yao Shen, Qiaoliang Zhu and Jian Zhou
    Citation: Respiratory Research 2023 24:297
  33. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience acute exacerbations (AE), which result in severe lung damage...

    Authors: Xu Ye, Mingrui Zhang, Huimin Gu, Mengying Liu, Yichao Zhao, Yanchen Shi, Shufei Wu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang and Mengshu Cao
    Citation: Respiratory Research 2023 24:296
  34. Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe ...

    Authors: Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andréanne Côté, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou and Jamila Chakir
    Citation: Respiratory Research 2023 24:294
  35. People living with chronic obstructive pulmonary disease (COPD) have an increased risk of experiencing cardiovascular (CV) events, particularly after an exacerbation. Such CV burden is not yet known for incide...

    Authors: Karin M. A. Swart, Brenda N. Baak, Louise Lemmens, Fernie J. A. Penning-van Beest, Camilla Bengtsson, Muriel Lobier, Fabian Hoti, Dina Vojinovic, Lindy van Burk, Kirsty Rhodes, Edeltraut Garbe, Ron M. C. Herings, Clementine Nordon and Sami O. Simons
    Citation: Respiratory Research 2023 24:293
  36. COVID-19 infections are associated with accrued inflammatory responses which may result in cardiac injury. Immune response to infection appears different between men and women, suggesting that COVID-19 patient...

    Authors: Mathieu Jozwiak, Denis Doyen, Pierre Denormandie, Antoine Goury, Jonathan Marey, Frédéric Pène, Alain Cariou, Jean-Paul Mira, Jean Dellamonica and Lee S. Nguyen
    Citation: Respiratory Research 2023 24:292
  37. Several observational studies have found that physical inactivity and sedentary time are associated with idiopathic pulmonary fibrosis (IPF) risk. However, the causality between them still requires further inv...

    Authors: Wanyang Lei, Mei Yang, Ziyu Yuan, Runlin Feng, Xiao Kuang, Zhiqiang Liu, Zongqi Deng, Xianglin Hu and Wenlin Tai
    Citation: Respiratory Research 2023 24:291
  38. FOOTPRINTS® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation/lung tissue destruction and chronic obstructive pulmonary disease (COPD) severity and progress...

    Authors: James D. Crapo, Abhya Gupta, David A. Lynch, Alice M. Turner, Robert M. Mroz, Wim Janssens, Andrea Ludwig-Sengpiel, Harald Koegler, Anastasia Eleftheraki, Frank Risse and Claudia Diefenbach
    Citation: Respiratory Research 2023 24:290
  39. Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is associated with the malignant phenotypes of pulmonary vascular cells. Rece...

    Authors: Congke Zhao, Xiangyang Le, Mengqi Li, Yuanbo Hu, Xiaohui Li, Zhuo Chen, Gaoyun Hu, Liqing Hu and Qianbin Li
    Citation: Respiratory Research 2023 24:289
  40. We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung damage before. However, limited knowledge exists concerning the biological role of S100A8/A...

    Authors: Jiang Yu, Boying Zhao, Qiangzhong Pi, Guoxiang Zhou, Zhe Cheng, Can Qu, Xiaowen Wang, Lingwen Kong, Suxin Luo, Dingyuan Du and Yongzheng Guo
    Citation: Respiratory Research 2023 24:288
  41. Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) ...

    Authors: Rachel Z. Blumhagen, Jonathan S. Kurche, Carlyne D. Cool, Avram D. Walts, David Heinz, Tasha E. Fingerlin, Ivana V. Yang and David A. Schwartz
    Citation: Respiratory Research 2023 24:287
  42. Hospital-acquired and ventilator-associated-pneumonia (HAP/VAP) are one of the most prevalent health-care associated infections in the intensive care unit (ICU). Culture-independent methods were therefore deve...

    Authors: Morgane Heitz, Albrice Levrat, Vladimir Lazarevic, Olivier Barraud, Stéphane Bland, Emmanuelle Santiago-Allexant, Karen Louis, Jacques Schrenzel and Sébastien Hauser
    Citation: Respiratory Research 2023 24:285
  43. Bronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsupervised machine learning approach, we created BPD subclasses (e.g., endotypes) by clust...

    Authors: Alvaro G. Moreira, Tanima Arora, Shreyas Arya, Caitlyn Winter, Charles T. Valadie and Przemko Kwinta
    Citation: Respiratory Research 2023 24:284
  44. Multiple prolonged symptoms are observed in patients who recover from acute coronavirus disease 2019 (COVID-19), defined as long COVID. Cough and sputum are presented by patients with long COVID during the acu...

    Authors: Mayuko Watase, Jun Miyata, Hideki Terai, Keeya Sunata, Emiko Matsuyama, Takanori Asakura, Ho Namkoong, Katsunori Masaki, Kazuma Yagi, Keiko Ohgino, Shotaro Chubachi, Ichiro Kawada, Takao Mochimaru, Ryosuke Satomi, Yoshitaka Oyamada, Keigo Kobayashi…
    Citation: Respiratory Research 2023 24:283
  45. To build prediction models with radiomics features, clinical/conventional radiographic signs and combined scores for the discrimination of micropapillary or solid subtypes (high-risk subtypes) of lung adenocar...

    Authors: Zhe Wang, Ning Zhang, Junhong Liu and Junfeng Liu
    Citation: Respiratory Research 2023 24:282
  46. Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking.

    Authors: Theodoros Karampitsakos, Apostolos Galaris, Serafeim Chrysikos, Ourania Papaioannou, Ioannis Vamvakaris, Ilianna Barbayianni, Paraskevi Kanellopoulou, Sofia Grammenoudi, Nektarios Anagnostopoulos, Grigoris Stratakos, Matthaios Katsaras, Fotios Sampsonas, Katerina Dimakou, Effrosyni D. Manali, Spyridon Papiris, Bochra Tourki…
    Citation: Respiratory Research 2023 24:279

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