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  1. Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) represents one of the most challenging scenarios for aerosol medicine. This challenge is highlighted by the undersized anato...

    Authors: Federico Bianco, Fabrizio Salomone, Ilaria Milesi, Xabier Murgia, Sauro Bonelli, Elena Pasini, Raffaele Dellacà, Maria Luisa Ventura and Jane Pillow
    Citation: Respiratory Research 2021 22:71
    Content type: Review Published on:

  2. In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, ...

    Authors: Flora Lemaire, Sandra Audonnet, Jeanne-Marie Perotin, Pierre Gaudry, Sandra Dury, Julien Ancel, François Lebargy, Frank Antonicelli, Gaëtan Deslée and Richard Le Naour
    Citation: Respiratory Research 2021 22:14
    Content type: Research Published on:

  3. Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a ...

    Authors: Kayoko Shimodaira, Yoichiro Okubo, Eri Ochiai, Haruo Nakayama, Harutaka Katano, Megumi Wakayama, Minoru Shinozaki, Takao Ishiwatari, Daisuke Sasai, Naobumi Tochigi, Tetsuo Nemoto, Tsutomu Saji, Katsuhiko Kamei and Kazutoshi Shibuya
    Citation: Respiratory Research 2012 13:103
    Content type: Research Published on:

  4. Systemic inflammation may contribute to cachexia in patients with chronic obstructive pulmonary disease (COPD). In this longitudinal study we assessed the association between circulating C-reactive protein (CR...

    Authors: Tomas ML Eagan, Esteban C Gabazza, Corina D’Alessandro-Gabazza, Paloma Gil-Bernabe, Shinya Aoki, Jon A Hardie, Per S Bakke and Peter D Wagner
    Citation: Respiratory Research 2012 13:48
    Content type: Research Published on:

  5. Recent guidelines recommended conducting spontaneous breathing trial (SBT) with modest inspiratory pressure augmentation rather than T-piece or continuous positive airway pressure. However, it was based on few...

    Authors: Soo Jin Na, Ryoung-Eun Ko, Jimyoung Nam, Myeong Gyun Ko and Kyeongman Jeon
    Citation: Respiratory Research 2022 23:22
    Content type: Research Published on:

  6. The dust mite Blomia tropicalis is an important source of aeroallergens in tropical areas. Although a mouse model for B. tropicalis extract (BtE)-induced asthma has been described, no study comparing different mo...

    Authors: Tiana Baqueiro, Momtchilo Russo, Virgínia MG Silva, Thayna Meirelles, Pablo RS Oliveira, Eliane Gomes, Renato Barboza, Ana T Cerqueira-Lima, Camila A Figueiredo, Lain Pontes-de-Carvalho and Neuza M Alcântara-Neves
    Citation: Respiratory Research 2010 11:51
    Content type: Research Published on:

  7. Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) ...

    Authors: Jaume Pons, Jaume Sauleda, Verónica Regueiro, Carmen Santos, Meritxell López, Joana Ferrer, Alvar GN Agustí and José A Bengoechea
    Citation: Respiratory Research 2006 7:64
    Content type: Research Published on:

  8. Formation of pulmonary tertiary immune structures is a characteristic feature of advanced COPD. In the current study, we investigated the mechanisms of tertiary lymphoid tissue (TLT) formation in the lungs of ...

    Authors: Mathieu C Morissette, Brian N Jobse, Danya Thayaparan, Jake K Nikota, Pamela Shen, Nancy Renée Labiris, Roland Kolbeck, Parameswaran Nair, Alison A Humbles and Martin R Stämpfli
    Citation: Respiratory Research 2014 15:49
    Content type: Research Published on:

  9. Increased apoptosis of alveolar epithelial cells is a prominent feature of pulmonary fibrosis. Macrophage efferocytosis, phagocytosis of apoptotic cells by macrophages, is crucial for maintaining tissue homeos...

    Authors: Yixin She, Xin Xu, Qingyang Yu, Xiangsheng Yang, Jianxing He and Xiao Xiao Tang
    Citation: Respiratory Research 2023 24:118
    Content type: Research Published on:

  10. The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects and is a potential early biomarker of lung damage. The CC16 single nucleotide polymorphism (SNP) rs3741240 risk allele (A) has ...

    Authors: KC Gribben, AB Wyss, JA Poole, PA Farazi, C Wichman, M Richards-Barber, LE Beane Freeman, PK Henneberger, DM Umbach, SJ London and TD LeVan
    Citation: Respiratory Research 2022 23:305
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2022 23:350

  11. Although corticosteroid therapy with dose tapering is the most commonly used treatment for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), there is no consensus on the tapering regimen. This stud...

    Authors: Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa and Yosuke Yamamoto
    Citation: Respiratory Research 2022 23:291
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2023 24:107

  12. Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease characterized by a persistent limitation in airflow. Gut microbiota is closely correlated with lung inflammation. However, gu...

    Authors: Yu-Chi Chiu, Shih-Wei Lee, Chi-Wei Liu, Tzuo-Yun Lan and Lawrence Shih-Hsin Wu
    Citation: Respiratory Research 2022 23:10
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2022 23:179

  13. Randomised, double-blind, controlled trials are considered the gold standard for evaluating a pharmacological agent, as they minimise any potential bias. However, it is not always possible to perform double-bl...

    Authors: Kai-Michael Beeh, Jutta Beier and James F Donohue
    Citation: Respiratory Research 2012 13:52
    Content type: Review Published on:

  14. Surfactant protein D (SP-D) plays an important role in innate defense against influenza A viruses (IAVs) and other pathogens.

    Authors: Kevan L Hartshorn, Richard Webby, Mitchell R White, Tesfaldet Tecle, Clark Pan, Susan Boucher, Rodney J Moreland, Erika C Crouch and Ronald K Scheule
    Citation: Respiratory Research 2008 9:65
    Content type: Research Published on:

  15. Late onset non-infectious pulmonary complications (LONIPCs) following allogenic hematopoietic stem cell transplantation (allo-HSCT) confer a significant mortality risk. Lung transplantation (LTx) has the poten...

    Authors: Peter Riddell, Ram Vasudevan-Nampoothiri, Jin Ma, Lianne G. Singer, Jeff H. Lipton and Stephen C. Juvet
    Citation: Respiratory Research 2021 22:101
    Content type: Research Published on:

  16. Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such ...

    Authors: Michelle Brand, Felix Ritzmann, Kathrin Kattler, Deivydas Milasius, Yiwen Yao, Christian Herr, Susanne H. Kirsch, Rolf Müller, Daniela Yildiz, Robert Bals and Christoph Beisswenger
    Citation: Respiratory Research 2024 25:3
    Content type: Research Published on:

  17. Neutrophil is of the most abundant number in human immune system. During acute influenza virus infection, neutrophils are already active in the early phase of inflammation - a time in which clinical biopsy or ...

    Authors: Louisa L. Y. Chan, John M. Nicholls, J. S. Malik Peiris, Yu Lung Lau, Michael C. W. Chan and Renee W. Y. Chan
    Citation: Respiratory Research 2020 21:160
    Content type: Research Published on:

  18. Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking.

    Authors: Theodoros Karampitsakos, Apostolos Galaris, Serafeim Chrysikos, Ourania Papaioannou, Ioannis Vamvakaris, Ilianna Barbayianni, Paraskevi Kanellopoulou, Sofia Grammenoudi, Nektarios Anagnostopoulos, Grigoris Stratakos, Matthaios Katsaras, Fotios Sampsonas, Katerina Dimakou, Effrosyni D. Manali, Spyridon Papiris, Bochra Tourki…
    Citation: Respiratory Research 2023 24:279
    Content type: Research Published on:

  19. Inhalation corticosteroids (ICS) are prescribed for treatment of asthma in approximately 3% of all children in Denmark. Despite limited evidence, case reports suggest that ICS-related behavioural adverse drug ...

    Authors: Karoline S. Bodum, Britta E. Hjerrild, Søren Dalsgaard and Sune L. M. Rubak
    Citation: Respiratory Research 2022 23:192
    Content type: Research Published on:

  20. Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, an...

    Authors: Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim and Edwin K Silverman
    Citation: Respiratory Research 2014 15:113
    Content type: Research Published on:

  21. Assessing the humoral immunity of patients with underlying diseases after being infected with SARS-CoV-2 is essential for adopting effective prevention and control strategies. The purpose of this study is to a...

    Authors: Jin Yang, Libing Ma, Li Guo, Ting Zhang, Zhiwei Leng, Mengmeng Jia, Fangyuan Chen, Weiran Qi, Xingxing Zhang, Qing Wang, Yuan Yang, Luzhao Feng, Lili Ren, Weizhong Yang and Chen Wang
    Citation: Respiratory Research 2022 23:188
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2022 23:218

  22. A suggested role for T cells in COPD pathogenesis is based on associations between increased lung cytotoxic T lymphocyte (CD8+) numbers and airflow limitation. CD69 is an early T cell activation marker. Natural K...

    Authors: Ester Roos-Engstrand, Jamshid Pourazar, Annelie F Behndig, Anders Blomberg and Anders Bucht
    Citation: Respiratory Research 2010 11:128
    Content type: Research Published on:

  23. Electronic cigarette (e-cig) vaping has increased in the past decade in the US, and e-cig use is misleadingly marketed as a safe cessation for quitting smoking. The main constituents in e-liquid are humectants...

    Authors: Qixin Wang, Joseph H Lucas, Cortney Pang, Ruogang Zhao and Irfan Rahman
    Citation: Respiratory Research 2024 25:23
    Content type: Research Published on:

  24. Mucus plugs have been described in the airways of asthmatic subjects, particularly those with associated with type 2 inflammation and sputum eosinophilia. In the current study we addressed the question of whet...

    Authors: Camille Audousset, Sana Swaleh, Ron Olivenstein, Motahareh Vameghestahbanati, Miranda Kirby, Alexandre Semionov, Benjamin M. Smith and James G. Martin
    Citation: Respiratory Research 2024 25:52
    Content type: Research Published on:

  25. In recent years, there has been increased interest in the vascular component of airway remodelling in chronic bronchial inflammation, such as asthma and COPD, and in its role in the progression of disease. In ...

    Authors: Andrea Zanini, Alfredo Chetta, Andrea S Imperatori, Antonio Spanevello and Dario Olivieri
    Citation: Respiratory Research 2010 11:132
    Content type: Review Published on:

  26. Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-der...

    Authors: Y Gaël Rochefort, Pascal Vaudin, Nicolas Bonnet, Jean-Christophe Pages, Jorge Domenech, Pierre Charbord and Véronique Eder
    Citation: Respiratory Research 2005 6:125
    Content type: Research Published on:

  27. Determinants of exhaled nitric oxide (FeNO) need to be understood better to maximize the value of FeNO measurement in clinical practice and research. Our aim was to identify significant predictors of FeNO in a...

    Authors: William S Linn, Edward B Rappaport, Kiros T Berhane, Tracy M Bastain, Edward L Avol and Frank D Gilliland
    Citation: Respiratory Research 2009 10:28
    Content type: Research Published on:

  28. Survivors of prematurity are at risk for abnormal childhood lung function. Few studies have addressed trajectories of lung function and risk factors for abnormal growth in childhood. This study aims to describ...

    Authors: Jonathan C. Levin, Catherine A. Sheils, Jonathan M. Gaffin, Craig P. Hersh, Lawrence M. Rhein and Lystra P. Hayden
    Citation: Respiratory Research 2021 22:143
    Content type: Research Published on:

  29. AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). Accumulating evidence has also revealed that AKT2 can promote NSCLC cell proliferation and metastasis. However, the...

    Authors: Ting Liu, Jianjie Zhu, Wenwen Du, Weiwei Ning, Yang Zhang, Yuanyuan Zeng, Zeyi Liu and Jian-An Huang
    Citation: Respiratory Research 2020 21:227
    Content type: Research Published on:

  30. Inhaled corticosteroids (ICS), especially when prescribed in combination with long-acting β2 agonists have been shown to improve COPD outcomes. Although there is consistent evidence linking ICS with adverse effec...

    Authors: Rob W Flynn, Thomas M MacDonald, Adrian Hapca, Isla S MacKenzie and Stuart Schembri
    Citation: Respiratory Research 2014 15:141
    Content type: Research Published on:

  31. Aging has been evidenced to bring about some structural and functional lung changes, especially in COPD. However, whether aging affects SAD, a possible precursor of COPD, has not been well characterized.

    Authors: Cuiqiong Dai, Fan Wu, Zihui Wang, Jieqi Peng, Huajing Yang, Youlan Zheng, Lifei Lu, Ningning Zhao, Zhishan Deng, Shan Xiao, Xiang Wen, Jianwu Xu, Peiyu Huang, Kunning Zhou, Xiaohui Wu, Yumin Zhou…
    Citation: Respiratory Research 2022 23:229
    Content type: Research Published on:

  32. Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker for the functional integrity of the lung and for disease progression, which can be detected in serum. The origin of SP-D in serum an...

    Authors: Carla Winkler, Elena N Atochina-Vasserman, Olaf Holz, Michael F Beers, Veit J Erpenbeck, Norbert Krug, Stefan Roepcke, Gereon Lauer, Martin Elmlinger and Jens M Hohlfeld
    Citation: Respiratory Research 2011 12:29
    Content type: Research Published on:

  33. Simvastatin has been shown to ameliorate pulmonary hypertension by several mechanisms in experimental animal models. In this study, we hypothesized that the major benefits of simvastatin in pulmonary hypertens...

    Authors: Hsao-Hsun Hsu, Wen-Je Ko, Jo-Yu Hsu, Jin-Shing Chen, Yung-Chie Lee, I-Rue Lai and Chau-Fong Chen
    Citation: Respiratory Research 2009 10:32
    Content type: Research Published on:

  34. The aim was to determine if effects from smoking on lung function measured over 11 years differ between men and women.

    Authors: Sara H Downs, Otto Brändli, Jean-Pierre Zellweger, Christian Schindler, Nino Künzli, Margaret W Gerbase, Luc Burdet, Robert Bettschart, Elisabeth Zemp, Martin Frey, Roland Keller, Jean-Marie Tschopp, Philippe Leuenberger and Ursula Ackermann-Liebrich
    Citation: Respiratory Research 2005 6:45
    Content type: Research Published on:

  35. Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship be...

    Authors: Toru Shirahata, Hideaki Sato, Sanehiro Yogi, Kaiji Inoue, Mamoru Niitsu, Tomoe Akagami, Machika Soma, Tomohiko Mio, Makoto Nagata, Satoshi Nakae, Yuki Nishida, Shigeho Tanaka, Fuminori Katsukawa and Hidetoshi Nakamura
    Citation: Respiratory Research 2021 22:18
    Content type: Research Published on:

  36. Persons with Chronic Obstructive Pulmonary Disease (COPD), performing some level of regular physical activity, have a lower risk of both COPD-related hospital admissions and mortality. COPD patients of all sta...

    Authors: Sigrid NW Vorrink, Helianthe SM Kort, Thierry Troosters and Jan-Willem J Lammers
    Citation: Respiratory Research 2011 12:33
    Content type: Review Published on:

  37. While well-characterised on its molecular base, non-small cell lung cancer (NSCLC) and its interaction with local microbiota remains scarcely explored. Moreover, current studies vary in source of lung microbio...

    Authors: Rea Bingula, Edith Filaire, Ioana Molnar, Eve Delmas, Jean-Yves Berthon, Marie-Paule Vasson, Annick Bernalier-Donadille and Marc Filaire
    Citation: Respiratory Research 2020 21:129
    Content type: Research Published on:

  38. We performed a multicenter, randomized open-label trial in patients with moderate to severe Covid-19 treated with a range of possible treatment regimens. Methods: Patients were randomly assigned to one of thre...

    Authors: Mostafa Ghanei, Masoud Solaymani-Dodaran, Ali Qazvini, Amir Hosein Ghazale, Seyed Amin Setarehdan, Seyed Hassan Saadat, Hassan Ghobadi, Saeed Hoseininia, Maryam Elahikhah, Ali Hossein Samadi, Yousef Imani, Ensieh Vahedi, Farhang Babamahmoodi, Fatemeh Tajik Rostami, Mohammad Hossein Azimzadeh Ardebili, Akram Ansarifar…
    Citation: Respiratory Research 2021 22:245
    Content type: Research Published on:

  39. Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, T...

    Authors: Saleh Al-Muhsen, Severine Letuve, Alejandro Vazquez-Tello, Mary Angeline Pureza, Hamdan Al-Jahdali, Ahmed S Bahammam, Qutayba Hamid and Rabih Halwani
    Citation: Respiratory Research 2013 14:34
    Content type: Research Published on:

  40. Bone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells ...

    Authors: Christian M Kähler, Jutta Wechselberger, Wolfgang Hilbe, Andreas Gschwendtner, Daniela Colleselli, Harald Niederegger, Eva-Maria Boneberg, Gilbert Spizzo, Albrecht Wendel, Eberhard Gunsilius, Josef R Patsch and Jürg Hamacher
    Citation: Respiratory Research 2007 8:50
    Content type: Research Published on:

  41. Osteoporosis is common in patients with COPD but the likely multi-factorial causes contributing to this condition (e.g. sex, age, smoking, therapy) mask the potential contribution from elements related to COPD. I...

    Authors: James M Duckers, Bronwen AJ Evans, William D Fraser, Michael D Stone, Charlotte E Bolton and Dennis J Shale
    Citation: Respiratory Research 2011 12:101
    Content type: Research Published on:

  42. While some lung adenocarcinoma (LUAD) patients benefit long-term from treatment with immune checkpoint inhibitors, the sad reality is that a considerable proportion of patients do not. The classification of th...

    Authors: Yuxin Wu, Kexin Li, Shuang Liang, Xiaoying Lou, Yiling Li, Danfei Xu, Yue Wu, Yuan Wang and Wei Cui
    Citation: Respiratory Research 2023 24:142
    Content type: Research Published on:

  43. The application of clinical mNGS for diagnosing respiratory infections improves etiology diagnosis, however at the same time, it brings new challenges as an unbiased sequencing method informing all identified ...

    Authors: Qing Miao, Tianzhu Liang, Na Pei, Chunjiao Liu, Jue Pan, Na Li, Qingqing Wang, Yanqiong Chen, Yu Chen, Yuyan Ma, Wenting Jin, Yao Zhang, Yi Su, Yumeng Yao, Yingnan Huang, Chunmei Zhou…
    Citation: Respiratory Research 2022 23:345
    Content type: Research Published on:

  44. Unfortunately, many COPD patients continue to exacerbate despite good adherence to GOLD Class D recommended therapy. Acute exacerbations lead to an increase in symptoms, decline in lung function and increased ...

    Authors: Michelle Brennan, M. J. McDonnell, M. J. Harrison, N. Duignan, A. O’Regan, D. M. Murphy, C. Ward and R. M. Rutherford
    Citation: Respiratory Research 2022 23:58
    Content type: Review Published on:

  45. We previously reported a Phase 1/2 randomized placebo-controlled trial of systemic administration of bone marrow-derived allogeneic MSCs (remestemcel-L) in COPD. While safety profile was good, no functional ef...

    Authors: Daniel J. Weiss, Karen Segal, Richard Casaburi, Jack Hayes and Donald Tashkin
    Citation: Respiratory Research 2021 22:142
    Content type: Research Published on:

  46. The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.

    Authors: Naijian Li, Zhaowei Yang, Baoling Liao, Tianhui Pan, Jinding Pu, Binwei Hao, Zhenli Fu, Weitao Cao, Yuming Zhou, Fang He, Bing Li and Pixin Ran
    Citation: Respiratory Research 2020 21:271
    Content type: Research Published on:

  47. Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment of causative ab...

    Authors: Jonathan Dedonder, Christelle Gelgon, Antoine Guerder, Nathalie Nion, Sophie Lavault, Capucine Morélot-Panzini, Jésus Gonzalez-Bermejo, Laelia Benoit, Thomas Similowski and Laure Serresse
    Citation: Respiratory Research 2024 25:21
    Content type: Research Published on:

  48. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold bet...

    Authors: M Innes Asher, Alistair W Stewart, Javier Mallol, Stephen Montefort, Christopher KW Lai, Nadia Aït-Khaled and Joseph Odhiambo
    Citation: Respiratory Research 2010 11:8
    Content type: Review Published on:

  50. There are no published studies assessing the evolution of combined determination of the lung diffusing capacity for both nitric oxide and carbon monoxide (DLNO and DLCO) 12 months after the discharge of patients ...

    Authors: Marta Núñez-Fernández, Cristina Ramos-Hernández, Francisco García-Río, Alexandre Pérez-González, Amara Tilve-Gómez, Paula Rodríguez-Fernández, Andrés Nodar-Germiñas, Alberto Fernández-García, Alberto Ruano-Raviña and Alberto Fernández-Villar
    Citation: Respiratory Research 2023 24:48
    Content type: Research Published on:
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