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  1. Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathol...

    Authors: Kate Blease, Nicholas W Lukacs, Cory M Hogaboam and Steven L Kunkel

    Citation: Respiratory Research 2000 1:13

    Content type: Review

    Published on:

  2. The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quant...

    Authors: Yassine Amrani, Hang Chen and Reynold A Panettieri Jr

    Citation: Respiratory Research 2000 1:12

    Content type: Review

    Published on:

  3. PM10 (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies...

    Authors: Kenneth Donaldson, M Ian Gilmour and William MacNee

    Citation: Respiratory Research 2000 1:5

    Content type: Commentary

    Published on:

  4. Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of...

    Authors: Alison M Condliffe, Karen A Cadwallader, Trevor R Walker, Robert C Rintoul, Andrew S Cowburn and Edwin R Chilvers

    Citation: Respiratory Research 2000 1:8

    Content type: Review

    Published on:

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