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  1. Periostin is a matricellular protein and is a useful marker in respiratory diseases. However, the roles of periostin in patients with obstructive sleep apnea (OSA) remain unclear. Several in vitro studies have...

    Authors: Hironobu Sunadome, Hisako Matsumoto, Ryo Tachikawa, Takeshi Matsumoto, Kiminobu Tanizawa, Toru Oga, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Toyohiro Hirai and Kazuo Chin

    Citation: Respiratory Research 2020 21:143

    Content type: Research

    Published on:

  2. Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immu...

    Authors: E. Beijer, B. Meek, X. Bossuyt, S. Peters, R. C. H. Vermeulen, H. Kromhout and M. Veltkamp

    Citation: Respiratory Research 2020 21:141

    Content type: Research

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  3. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal model, alveolar simplification and pro-inflammato...

    Authors: Shangqin Chen, Qiuping Wu, Dingjuan Zhong, Changchong Li and Lizhong Du

    Citation: Respiratory Research 2020 21:140

    Content type: Research

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  4. This analysis of the IMPACT study assessed the cardiovascular (CV) safety of single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus FF/VI and UMEC/VI dual therapy.

    Authors: Nicola C. Day, Subramanya Kumar, Gerard Criner, Mark Dransfield, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Morrys C. Kaisermann, Sally Kilbride, Peter Lange, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert Wise and David A. Lipson

    Citation: Respiratory Research 2020 21:139

    Content type: Research

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  5. Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated w...

    Authors: Cristóbal Esteban, Inmaculada Arostegui, Amaia Aramburu, Javier Moraza, Josu Najera-Zuloaga, Myriam Aburto, Susana Aizpiri, Leyre Chasco and José M. Quintana

    Citation: Respiratory Research 2020 21:138

    Content type: Research

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  6. Treatment of Chronic Obstructive Pulmonary Disease (COPD) is based on bronchodilation, with inhaled corticosteroids or azithromycin associated when frequent exacerbations occur. Despite the proven benefits of ...

    Authors: Carolien Mathyssen, Celine Aelbrecht, Jef Serré, Stephanie Everaerts, Karen Maes, Ghislaine Gayan-Ramirez, Bart Vanaudenaerde and Wim Janssens

    Citation: Respiratory Research 2020 21:137

    Content type: Research

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  7. Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. T...

    Authors: Balram Neupane, Akylbek Sydykov, Kabita Pradhan, Christina Vroom, Christiane Herden, Srikanth Karnati, Hossein Ardeschir Ghofrani, Sergey Avdeev, Süleyman Ergün, Ralph Theo Schermuly and Djuro Kosanovic

    Citation: Respiratory Research 2020 21:136

    Content type: Research

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  8. Given the heterogeneity of chronic obstructive pulmonary disease (COPD), personalized clinical management is key to optimizing patient outcomes. Important treatment goals include minimizing disease activity an...

    Authors: Dave Singh, Gerard J. Criner, Ian Naya, Paul W. Jones, Lee Tombs, David A. Lipson and MeiLan K. Han

    Citation: Respiratory Research 2020 21:134

    Content type: Review

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  9. Lumacaftor/ivacaftor (LUM/IVA) modestly improves lung function following 1 month of treatment but it is unknown if this translates into improvements in exercise endurance and exertional symptoms.

    Authors: Bradley S. Quon, Andrew H. Ramsook, Satvir S. Dhillon, Reid A. Mitchell, Kyle G. Boyle, Pearce G. Wilcox and Jordan A. Guenette

    Citation: Respiratory Research 2020 21:135

    Content type: Letter to the Editor

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  10. Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tom...

    Authors: Taewoo Kim, Hyun Bin Cho, Woo Jin Kim, Chang Hyun Lee, Kum Ju Chae, So-Hyun Choi, Kyeong Eun Lee, So Hyeon Bak, Sung Ok Kwon, Gong Yong Jin, Jiwoong Choi, Eun-Kee Park, Ching-Long Lin, Eric A. Hoffman and Sanghun Choi

    Citation: Respiratory Research 2020 21:133

    Content type: Research

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  11. Chronic tissue injury was shown to induce progressive scarring in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), while an array of repair/regeneration and stress responses come to equilibrium t...

    Authors: Xiaofei Cong, Nagaraja Nagre, Jeremy Herrera, Andrew C. Pearson, Ian Pepper, Robell Morehouse, Hong-Long Ji, Dianhua Jiang, Rolf D. Hubmayr and Xiaoli Zhao

    Citation: Respiratory Research 2020 21:132

    Content type: Research

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  12. The comparative efficacy of inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) triple therapy administered via single or multiple inhalers in patients with chronic obs...

    Authors: Gary T. Ferguson, Nicola Brown, Chris Compton, Thomas C. Corbridge, Kelly Dorais, Charles Fogarty, Catherine Harvey, Morrys C. Kaisermann, David A. Lipson, Neil Martin, Frank Sciurba, Marjorie Stiegler, Chang-Qing Zhu and David Bernstein

    Citation: Respiratory Research 2020 21:131

    Content type: Research

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  13. It has been confirmed that NF-κB p65 signaling pathway is involved in the regulation of alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome (ARDS). Whether SN50, a NF-κ...

    Authors: Yanqi Wu, Yahui Wang, Bo Liu, Yumei Cheng, Hong Qian, Huilin Yang, Xiang Li, Guixia Yang, Xinghao Zheng and Feng Shen

    Citation: Respiratory Research 2020 21:130

    Content type: Research

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  14. The Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting bronchodilator for chronic obstructive pulmonary disease...

    Authors: Fernando J. Martinez, Brian J. Lipworth, Klaus F. Rabe, David J. Collier, Gary T. Ferguson, Sanjay Sethi, Gregory J. Feldman, Gerald O’Brien, Martin Jenkins and Colin Reisner

    Citation: Respiratory Research 2020 21:128

    Content type: Research

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  15. The objective of this study was to analyze prognostic factors and risk stratification in patients with pulmonary arterial hypertension (PAH) and comorbidities.

    Authors: Panagiota Xanthouli, Maria Koegler, Alberto M. Marra, Nicola Benjamin, Lukas Fischer, Christina A. Eichstaedt, Satenik Harutyunova, Christian Nagel, Ekkehard Grünig and Benjamin Egenlauf

    Citation: Respiratory Research 2020 21:127

    Content type: Research

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  16. Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging fo...

    Authors: Nilanjana Ghosh, Priyanka Choudhury, Sandeep Rai Kaushik, Rakesh Arya, Ranjan Nanda, Parthasarathi Bhattacharyya, Sushmita Roychowdhury, Rintu Banerjee and Koel Chaudhury

    Citation: Respiratory Research 2020 21:126

    Content type: Research

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  17. A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at e...

    Authors: Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang and Bo Liang

    Citation: Respiratory Research 2020 21:125

    Content type: Research

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  18. One of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated th...

    Authors: Gerald Birk, Marc Kästle, Cornelia Tilp, Birgit Stierstorfer and Stephan Klee

    Citation: Respiratory Research 2020 21:124

    Content type: Research

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  19. Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respirat...

    Authors: Jinzhun Wu, Dandan Ge, Taoling Zhong, Zuojia Chen, Ying Zhou, Lingyun Hou, Xiaoliang Lin, Jiaxu Hong, Kuai Liu, Hui Qi, Chaoying Wang, Yulin Zhou, Cheng Li, Chuan Wu, Shuiping Wu, Zuguo Liu…

    Citation: Respiratory Research 2020 21:123

    Content type: Research

    Published on:

  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alex J. van ’t Hul, Noortje H. Koolen, Jeroen W. van Hees, Bram van den Borst and Martijn A. Spruit

    Citation: Respiratory Research 2020 21:122

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:112

  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Margaret Gilfillan, Pragnya Das, Dilip Shah, Mohammad Afaque Alam and Vineet Bhandari

    Citation: Respiratory Research 2020 21:121

    Content type: Correction

    Published on:

    The original article was published in Respiratory Research 2020 21:92

  22. The predominant metastatic site of lung cancer (LC) is the brain. Although outdated, conventional cisplatin treatment is still the main therapeutic approach for patients with advanced non-small cell lung cance...

    Authors: Edit Kiss, El Husseiny Mohamed Mahmud Abdelwahab, Anita Steib, Emoke Papp, Zsofia Torok, Laszlo Jakab, Gabor Smuk, Veronika Sarosi and Judit Erzsebet Pongracz

    Citation: Respiratory Research 2020 21:120

    Content type: Research

    Published on:

  23. Progression of the disease in idiopathic pulmonary fibrosis (IPF) is difficult to predict, due to its variable and heterogenous course. The relationship between radiographic progression and functional decline ...

    Authors: Nada Taha, Dejanira D’Amato, Karishma Hosein, Tiziana Ranalli, Gianluigi Sergiacomi, Maurizio Zompatori and Marco Mura

    Citation: Respiratory Research 2020 21:119

    Content type: Research

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  24. Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive statins. ...

    Authors: AJN Raymakers, D. D. Sin, M. Sadatsafavi, JM FitzGerald, C. A. Marra and L. D. Lynd

    Citation: Respiratory Research 2020 21:118

    Content type: Research

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  25. Targeted lung denervation (TLD), a novel bronchoscopic procedure which attenuates pulmonary nerve input to the lung to reduce the clinical consequences of neural hyperactivity, may be an important emerging tre...

    Authors: Martin L. Mayse, Holly S. Norman, Alexander D. Peterson, Kristina T. Rouw and Philip J. Johnson

    Citation: Respiratory Research 2020 21:117

    Content type: Research

    Published on:

  26. This study was conducted to evaluate the relationship between nasal resistance in different posture and optimal positive airway pressure (PAP) level. Other potential factors were also assessed for possible inf...

    Authors: Yen-Bin Hsu, Stanley Yung-Chuan Liu, Ming-Ying Lan, Yun-Chen Huang, I-Shiang Tzeng and Ming-Chin Lan

    Citation: Respiratory Research 2020 21:115

    Content type: Research

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  27. High FiO2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E1 (PGE1) can improve oxy...

    Authors: Pengyi Li, Lianbing Gu, Qingming Bian, Jing Tan, Dian Jiao, Fei Wu, Zeping Xu and Lijun Wang

    Citation: Respiratory Research 2020 21:113

    Content type: Research

    Published on:

  28. Authors: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit

    Citation: Respiratory Research 2020 21:112

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:122

    The original article was published in Respiratory Research 2020 21:27

    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:114

  29. Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number o...

    Authors: Ryan Brown, Sridesh Nath, Alnardo Lora, Ghassan Samaha, Ziyad Elgamal, Ryan Kaiser, Clifford Taggart, Sinéad Weldon and Patrick Geraghty

    Citation: Respiratory Research 2020 21:111

    Content type: Review

    Published on:

  30. The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective i...

    Authors: Sirous Sadeghian Chaleshtori, Mohammad Reza Mokhber Dezfouli and Massoumeh Jabbari Fakhr

    Citation: Respiratory Research 2020 21:110

    Content type: Review

    Published on:

  31. The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

    Authors: Liang Chen, Xiudi Han, Yan Li Li, Chunxiao Zhang and Xiqian Xing

    Citation: Respiratory Research 2020 21:109

    Content type: Research

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  32. Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

    Authors: Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese, Carmel B. Nanthakumar, Vikki J. Barrett, Robert B. Good, Sarah Brockbank, Simon Cruwys, Henrik Jessen, Grith Lykke Sorensen, Morten Asser Karsdal, Diana Julie Leeming and Jannie Marie Bülow Sand

    Citation: Respiratory Research 2020 21:108

    Content type: Research

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  33. Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

    Authors: Julie Weidner, Linda Ekerljung, Carina Malmhäll, Nicolae Miron and Madeleine Rådinger

    Citation: Respiratory Research 2020 21:107

    Content type: Research

    Published on:

  34. In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...

    Authors: Timm Greulich, Julia Tüffers, Sina Mager, Anna Eder, Michael Maxheim, Peter Alter, Bernd Schmeck and Claus F. Vogelmeier

    Citation: Respiratory Research 2020 21:106

    Content type: Research

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  35. Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

    Authors: Nirmal S. Sharma, Grant Vestal, Keith Wille, Kapil N. Patel, Feng Cheng, Srinivas Tipparaju, Sultan Tousif, Mudassir M. Banday, Xin Xu, Landon Wilson, Viswam S. Nair, Casey Morrow, Don Hayes Jr, Andreas Seyfang, Stephen Barnes, Jessy S. Deshane…

    Citation: Respiratory Research 2020 21:104

    Content type: Research

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  36. Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, James D. Crapo, Barry J. Make, David A. Lynch, Vito Brusasco, Federico Lavorini, Edwin K. Silverman, Elizabeth A. Regan and Massimo Pistolesi

    Citation: Respiratory Research 2020 21:103

    Content type: Research

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  37. In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

    Authors: Yanan Yin, Ganesh Vilas Shelke, Cecilia Lässer, Hjalmar Brismar and Jan Lötvall

    Citation: Respiratory Research 2020 21:101

    Content type: Research

    Published on:

  38. Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

    Authors: Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko…

    Citation: Respiratory Research 2020 21:100

    Content type: Research

    Published on:

  39. There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

    Authors: Jing Xu, Tingting Pan, Xiaoling Qi, Ruoming Tan, Xiaoli Wang, Zhaojun Liu, Zheying Tao, Hongping Qu, Yi Zhang, Hong Chen, Yihui Wang, Jingjing Zhang, Jie Wang and Jialin Liu

    Citation: Respiratory Research 2020 21:99

    Content type: Research

    Published on:

  40. Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...

    Authors: David I. Kasahara and Stephanie A. Shore

    Citation: Respiratory Research 2020 21:98

    Content type: Research

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  41. Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor pro...

    Authors: Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian and Jill A. Poole

    Citation: Respiratory Research 2020 21:97

    Content type: Research

    Published on:

  42. The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease pr...

    Authors: Jing Gao, Jun-Qiang Liu, Heng-Jun Wen, Hua Liu, Wei-Dong Hu, Xia Han, Chuan-Xing Li and Xiao-Jun Wang

    Citation: Respiratory Research 2020 21:96

    Content type: Letter to the Editor

    Published on:

  43. It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and ...

    Authors: Xiaomin Dang, Beibei He, Qian Ning, Ya Liu, Jianxin Guo, Gang Niu and Mingwei Chen

    Citation: Respiratory Research 2020 21:95

    Content type: Research

    Published on:

  44. A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO2/FlO2, and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasi...

    Authors: Hyeontaek Hwang, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Sang-Min Lee

    Citation: Respiratory Research 2020 21:94

    Content type: Research

    Published on:

  45. COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.

    Authors: Alexander J. Mackay, Konstantinos Kostikas, Nicolas Roche, Stefan-Marian Frent, Petter Olsson, Pascal Pfister, Pritam Gupta, Francesco Patalano, Donald Banerji and Jadwiga A. Wedzicha

    Citation: Respiratory Research 2020 21:93

    Content type: Research

    Published on:

  46. Macrophage migration inhibitory factor (MIF) has been implicated as a protective factor in the development of bronchopulmonary dysplasia (BPD) and is known to be regulated by MicroRNA-451 (miR-451). The aim of...

    Authors: Margaret Gilfillan, Pragnya Das, Dilip Shah, Mohammad Afaque Alam and Vineet Bhandari

    Citation: Respiratory Research 2020 21:92

    Content type: Research

    Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:121

  47. Idiopathic pulmonary fibrosis (IPF) specific version of St. George’s Respiratory Questionnaire (SGRQ-I) and King’s Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Ole Hilberg, Saher Burhan Shaker, Jesper Rømhild Davidsen and Elisabeth Bendstrup

    Citation: Respiratory Research 2020 21:91

    Content type: Research

    Published on:

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