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  1. Content type: Research

    Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calc...

    Authors: Merry-Lynn N. McDonald, Emiel F. M. Wouters, Erica Rutten, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Marcas Bamman, Bartolome Celli, Alvar Agusti, Ruth Tal-Singer, Craig P. Hersh, Mark Dransfield and Edwin K. Silverman

    Citation: Respiratory Research 2019 20:100

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  2. Content type: Research

    Nitric oxide is a mediator of potential importance in numerous physiological and inflammatory processes in the lung. Aminoguanidine (AG) has been shown to have anti-inflammation and radical scavenging properti...

    Authors: Saeideh Saadat, Farimah Beheshti, Vahid Reza Askari, Mahmoud Hosseini, Nema Mohamadian Roshan and Mohammad Hossein Boskabady

    Citation: Respiratory Research 2019 20:96

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  3. Content type: Research

    Tobacco smoke exposure impairs the lung’s innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has antimicrobial activi...

    Authors: Patrick J. Moore, Juliana Sesma, Neil E. Alexis and Robert Tarran

    Citation: Respiratory Research 2019 20:94

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  4. Content type: Research

    One of the known weaknesses of spirometry is its dependence on patients’ cooperation, which can only partially be alleviated by educational efforts. Therefore, procedures less dependent on cooperation might be...

    Authors: Christina Kellerer, Neele Jankrift, Rudolf A. Jörres, Klaus Klütsch, Stefan Wagenpfeil, Klaus Linde and Antonius Schneider

    Citation: Respiratory Research 2019 20:92

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  5. Content type: Research

    Wheezing among children below the age of six (pre-schoolers) is common and often triggered by environmental factors. Moreover, evidence on which to base recommendations for its management is limited, resulting...

    Authors: Sonia Trabelsi, Lidia Casas, Benoit Nemery, Tim S. Nawrot and Isabelle Thomas

    Citation: Respiratory Research 2019 20:90

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  6. Content type: Research

    The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Init...

    Authors: Florin Mihaltan, Yochai Adir, Adam Antczak, Konstantinos Porpodis, Vesna Radulovic, Nuno Pires, Geeuwke Jan de Vries, Andreas Horner, Samuel De Bontridder, Yunqin Chen, Anat Shavit, Silviu Alecu and Lukasz Adamek

    Citation: Respiratory Research 2019 20:89

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  7. Content type: Research

    While additional oxygen supply is often required for the survival of very premature infants in intensive care, this also brings an increasing risk of progressive lung diseases and poor long-term lung outcomes....

    Authors: Stefanie Endesfelder, Evelyn Strauß, Till Scheuer, Thomas Schmitz and Christoph Bührer

    Citation: Respiratory Research 2019 20:88

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  8. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechani...

    Authors: Eva Schruf, Victoria Schroeder, Christian A. Kuttruff, Sabine Weigle, Martin Krell, Maryke Benz, Tom Bretschneider, Alexander Holweg, Michael Schuler, Manfred Frick, Paul Nicklin, James P. Garnett and Mirko C. Sobotta

    Citation: Respiratory Research 2019 20:87

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  9. Content type: Research

    Platelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between p...

    Authors: Ashraf Fawzy, Julie A. Anderson, Nicholas J. Cowans, Courtney Crim, Robert Wise, Julie C. Yates and Nadia N. Hansel

    Citation: Respiratory Research 2019 20:86

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  10. Content type: Research

    Although bronchodilator inhaler therapy can improve lung function in patients with tuberculous destroyed lung (TDL), its effect on mortality has not been studied. We evaluated the effect of tiotropium inhaler ...

    Authors: Ho Cheol Kim, Tae Hoon Kim, Ye-Jee Kim, Chin Kook Rhee and Yeon-Mok Oh

    Citation: Respiratory Research 2019 20:85

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  11. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction ca...

    Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang and Qin Wang

    Citation: Respiratory Research 2019 20:84

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  12. Content type: Letter to the Editor

    An inverse relationship between oral corticosteroid (OCS) dose and peripheral blood eosinophil (PBE) count is widely recognized in patients with severe eosinophilic asthma; however, there are limited data avai...

    Authors: Charlene M. Prazma, Elisabeth H. Bel, Robert G. Price, Eric S. Bradford, Frank C. Albers and Steven W. Yancey

    Citation: Respiratory Research 2019 20:83

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  13. Content type: Research

    Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Antibiotics are losing their effectiveness due to the emerging infectious diseases, the scarcity of novel antibiotics...

    Authors: Yali Zheng, Pu Ning, Qiongzhen Luo, Yukun He, Xu Yu, Xiaohui Liu, Yusheng Chen, Xiaorong Wang, Yu Kang and Zhancheng Gao

    Citation: Respiratory Research 2019 20:82

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  14. Content type: Research

    Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap...

    Authors: Hye-Rim Kang, Sung-Hyun Hong, So-Young Ha, Tae-Bum Kim and Eui-Kyung Lee

    Citation: Respiratory Research 2019 20:80

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  15. Content type: Research

    C-X-C chemokine receptor type 4 (CXCR4) may be involved in the development of pulmonary arterial hypertension (PAH). CXCR4 inhibitor AMD3100 was described to have a positive effect on the prevention of pulmona...

    Authors: Tingting Zhang, Nanako Kawaguchi, Kenji Yoshihara, Emiko Hayama, Yoshiyuki Furutani, Kayoko Kawaguchi, Takeshi Tanaka and Toshio Nakanishi

    Citation: Respiratory Research 2019 20:79

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  16. Content type: Research

    In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance. High-resolution computed tomography (HRCT) of the lung c...

    Authors: Ernesto Crisafulli, Elisabetta Teopompi, Silvia Luceri, Francesco Longo, Panagiota Tzani, Paolo Pagano, Antonella Ielpo, Chiara Longo, Marcello Di Paolo, Nicola Sverzellati, Paolo Palange, Alfredo Chetta and Giovanna Pisi

    Citation: Respiratory Research 2019 20:78

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  17. Content type: Research

    Decreased airway lumen size and increased lung volume are major structural changes in chronic obstructive pulmonary disease (COPD). However, even though the outer wall of the airways is connected with lung par...

    Authors: Naoya Tanabe, Susumu Sato, Tsuyoshi Oguma, Hiroshi Shima, Atsuyasu Sato, Shigeo Muro and Toyohiro Hirai

    Citation: Respiratory Research 2019 20:77

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  18. Content type: Research

    Exposure to fine particulate matter (PM2.5) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM2.5-induced toxicity may provide ...

    Authors: Juan Li, Hang Li, Haibin Li, Weili Guo, Zhen An, Xiang Zeng, Wen Li, Huijun Li, Jie Song and Weidong Wu

    Citation: Respiratory Research 2019 20:76

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  19. Content type: Research

    It is not known if the endogenous surfactant pool available early in life is associated with the RDS clinical course in preterm neonates treated with CPAP. We aim to clarify the clinical factors affecting surf...

    Authors: Roberto Raschetti, Roberta Centorrino, Emmanuelle Letamendia, Alexandra Benachi, Anne Marfaing-Koka and Daniele De Luca

    Citation: Respiratory Research 2019 20:75

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  20. Content type: Research

    Pulmonary vascular abnormalities are a characteristic feature of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most important risk factor for COPD. It is believed that its constant exp...

    Authors: Olga Tura-Ceide, Sandra Pizarro, Jéssica García-Lucio, Josep Ramírez, Laureano Molins, Isabel Blanco, Yolanda Torralba, Marta Sitges, Cristina Bonjoch, Victor I. Peinado and Joan Albert Barberà

    Citation: Respiratory Research 2019 20:74

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  21. Content type: Research

    N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients.

    Authors: Qian Qi, Yirepanjaing Ailiyaer, Ruijuan Liu, Yan Zhang, Caiyu Li, Mingtao Liu, Xiuxiu Wang, Lijun Jing and Yu Li

    Citation: Respiratory Research 2019 20:73

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  22. Content type: Research

    Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unk...

    Authors: Joseph Jude, Danielle Botelho, Nikhil Karmacharya, Gao Yuan Cao, William Jester and Reynold A. Panettieri Jr

    Citation: Respiratory Research 2019 20:72

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  23. Content type: Research

    Given the broad definition of an acute exacerbation of IPF, it is likely that acute exacerbations are heterogeneous in their aetiology, severity and clinical course. We used pooled data from the INPULSIS® tria...

    Authors: Michael Kreuter, Harald Koegler, Matthias Trampisch, Silke Geier and Luca Richeldi

    Citation: Respiratory Research 2019 20:71

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  24. Content type: Letter to the Editor

    Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signali...

    Authors: Alen Faiz, Maarten van den Berge, Cornelis J. Vermeulen, Nick H. T. ten Hacken, Victor Guryev and Simon D. Pouwels

    Citation: Respiratory Research 2019 20:70

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  25. Content type: Research

    Among patients with chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM) is a common comorbidity and is probably associated with increased systemic inflammation and worse prognosis. Metformin, ...

    Authors: Te-Wei Ho, Chun-Ta Huang, Yi-Ju Tsai, Angela Shin-Yu Lien, Feipei Lai and Chong-Jen Yu

    Citation: Respiratory Research 2019 20:69

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  26. Content type: Letter to the Editor

    The study by Kiranantawat et al. “Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation” highlights how “pulmonary consolidation...

    Authors: Marco Sperandeo, Anna Del Colle, Elisabettamaria Frongillo, Gaetano Rea, Lucia Dimitri, Cristiana Cipriani and Donato Lacedonia

    Citation: Respiratory Research 2019 20:68

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  27. Content type: Research

    Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related breathing disorder, characterized by excessive daytime sleepiness (EDS), paralleled by intermittent collapse of the upper airway. EDS may be...

    Authors: Csaba E. More, Csaba Papp, Szilvia Harsanyi, Rudolf Gesztelyi, Angela Mikaczo, Gabor Tajti, Laszlo Kardos, Ildiko Seres, Hajnalka Lorincz, Krisztina Csapo and Judit Zsuga

    Citation: Respiratory Research 2019 20:67

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  28. Content type: Research

    Interferon gamma (IFN-γ) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and management of respiratory diseases such as tuberculosis and pulmonar...

    Authors: Louise Sweeney, Alice P. McCloskey, Gerard Higgins, Joanne M. Ramsey, Sally-Ann Cryan and Ronan MacLoughlin

    Citation: Respiratory Research 2019 20:66

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  29. Content type: Research

    Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, al...

    Authors: Jarrett D. Morrow, Robert P. Chase, Margaret M. Parker, Kimberly Glass, Minseok Seo, Miguel Divo, Caroline A. Owen, Peter Castaldi, Dawn L. DeMeo, Edwin K. Silverman and Craig P. Hersh

    Citation: Respiratory Research 2019 20:65

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  30. Content type: Research

    A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD), although little is known about the shared genet...

    Authors: Zhaozhong Zhu, Xiaofang Wang, Xihao Li, Yifei Lin, Sipeng Shen, Cong-Lin Liu, Brain D. Hobbs, Kohei Hasegawa, Liming Liang, H. Marike Boezen, Carlos A. Camargo Jr, Michael H. Cho and David C. Christiani

    Citation: Respiratory Research 2019 20:64

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  31. Content type: Research

    Identifying subjects with chronic obstructive pulmonary disease (COPD) at high risk of exacerbation and mortality is key to aid individual management of COPD. The only FDA approved blood-based drug development...

    Authors: Sarah Rank Rønnow, Jannie Marie Bülow Sand, Lasse Løcke Langholm, Tina Manon-Jensen, Morten Asser Karsdal, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo and Diana Julie Leeming

    Citation: Respiratory Research 2019 20:63

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  32. Content type: Research

    This cohort study of patients with chronic obstructive pulmonary disease (COPD) was performed to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the Global Init...

    Authors: Se Hee Lee, Ji-Hyun Lee, Ho Il Yoon, Hye Yun Park, Tae-Hyung Kim, Kwang Ha Yoo, Yeon-Mok Oh, Ki Suk Jung, Sang-Do Lee and Sei Won Lee

    Citation: Respiratory Research 2019 20:62

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  33. Content type: Research

    COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the l...

    Authors: Peter Alter, Henrik Watz, Kathrin Kahnert, Klaus F. Rabe, Frank Biertz, Ronald Fischer, Philip Jung, Jana Graf, Robert Bals, Claus F. Vogelmeier and Rudolf A. Jörres

    Citation: Respiratory Research 2019 20:61

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  34. Content type: Research

    Symptomatic patients with chronic obstructive pulmonary disease (COPD) and low exacerbation risk still have disease instability, which can be improved with better bronchodilation. We evaluated two long-acting ...

    Authors: Ian Naya, Lee Tombs, David A. Lipson, Isabelle Boucot and Chris Compton

    Citation: Respiratory Research 2019 20:60

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  35. Content type: Research

    Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German ...

    Authors: Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F. Meyer, Joachim Kirschner…

    Citation: Respiratory Research 2019 20:59

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  36. Content type: Research

    Noninvasive high-frequency oscillatory ventilation (nHFOV), a relatively new modality, is gaining popularity despite scarce evidence. This meta-analysis was designed to evaluate the efficacy and safety of nHFO...

    Authors: Jing Li, Xiaoxia Li, Xianmei Huang and Zhiqun Zhang

    Citation: Respiratory Research 2019 20:58

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  37. Content type: Research

    Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, musc...

    Authors: Sabina A. Guler, Seo Am Hur, Scott A. Lear, Pat G. Camp and Christopher J. Ryerson

    Citation: Respiratory Research 2019 20:56

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  38. Content type: Letter to the Editor

    Data from controlled clinical studies in patients with more advanced idiopathic pulmonary fibrosis (IPF) could inform clinical practice, but they are limited, since this sub-population is usually excluded from...

    Authors: Ulrich Costabel, Carlo Albera, Marilyn K. Glassberg, Lisa H. Lancaster, Wim A. Wuyts, Ute Petzinger, Frank Gilberg, Klaus-Uwe Kirchgaessler and Paul W. Noble

    Citation: Respiratory Research 2019 20:55

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  39. Content type: Research

    Recently, lymphoid follicle-confined and circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, which was involved in anti-virus immune response. However, the dynamics ...

    Authors: Yu Shen, Qiu-xia Qu, Meng-ni Jin and Cheng Chen

    Citation: Respiratory Research 2019 20:54

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  40. Content type: Research

    In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.

    Authors: Junsong Gong, Zujun Chen, Yu Chen, Huanran Lv, Haisong Lu, Fuxia Yan, Lihuan Li, Weili Zhang and Jia Shi

    Citation: Respiratory Research 2019 20:53

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  41. Content type: Research

    Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases....

    Authors: Kristi J. Warren, John D. Dickinson, Amy J. Nelson, Todd A. Wyatt, Debra J. Romberger and Jill A. Poole

    Citation: Respiratory Research 2019 20:51

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  42. Content type: Research

    Macrophage migration inhibitory factor (MIF) makes chemokine-like functions and plays critical roles in various inflammatory diseases. This study was designed to explore the significance of MIF serum levels in...

    Authors: Qingjiang Wang, Wei Han, Junmei Niu, Bing Sun, Wei Dong and Guangpeng Li

    Citation: Respiratory Research 2019 20:50

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  43. Content type: Research

    Previous studies have shown that miR-144-3p might be a potential biomarker in non-small cell lung cancer (NSCLC). Nevertheless, the comprehensive mechanism behind the effects of miR-144-3p on the origin, diffe...

    Authors: Yu-Ji Chen, Yi-Nan Guo, Ke Shi, Hui-Mei Huang, Shu-Ping Huang, Wen-Qing Xu, Zu-Yun Li, Kang-Lai Wei, Ting-Qing Gan and Gang Chen

    Citation: Respiratory Research 2019 20:48

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  44. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of ...

    Authors: Sabine Witt, Ekaterina Krauss, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol U. Wells, Martina Vasakova, Alberto Pesci, Walter Klepetko, Werner Seeger, Bruno Crestani, Reiner Leidl, Rolf Holle, Larissa Schwarzkopf and Andreas Guenther

    Citation: Respiratory Research 2019 20:47

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  45. Content type: Research

    There is a paucity of data from large prospective study evaluating the prognostic significance of the residual Synergy between percutaneous intervention with Taxus drug-eluting stents and cardiac surgery (SYNT...

    Authors: Yaping Zeng, Shuhan Yang, Xiao Wang, Jingyao Fan, Shaoping Nie and Yongxiang Wei

    Citation: Respiratory Research 2019 20:43

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