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  1. Observational data under real-life conditions in idiopathic pulmonary fibrosis (IPF) is scarce. We explored anti-fibrotic treatment, disease severity and phenotypes in patients with IPF from the Swedish IPF Re...

    Authors: Jing Gao, Dimitrios Kalafatis, Lisa Carlson, Ida H. A. Pesonen, Chuan-Xing Li, Åsa Wheelock, Jesper M. Magnusson and C. Magnus Sköld

    Citation: Respiratory Research 2021 22:40

    Content type: Research

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  2. Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 i...

    Authors: D. J. Leeming, F. Genovese, J. M. B. Sand, D. G. K. Rasmussen, C. Christiansen, G. Jenkins, T. M. Maher, J. Vestbo and M. A. Karsdal

    Citation: Respiratory Research 2021 22:38

    Content type: Commentary

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  3. Comorbidities play a key role in severe disease outcomes in COVID-19 patients. However, the literature on preexisting respiratory diseases and COVID-19, accounting for other possible confounders, is limited. T...

    Authors: Prateek Lohia, Kalyan Sreeram, Paul Nguyen, Anita Choudhary, Suman Khicher, Hossein Yarandi, Shweta Kapur and M. Safwan Badr

    Citation: Respiratory Research 2021 22:37

    Content type: Research

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  4. Control in COPD is a dynamic concept that can reflect changes in patients’ clinical status that may have prognostic implications, but there is no information about changes in control status and its long-term c...

    Authors: Myriam Calle Rubio, Juan Luis Rodriguez Hermosa, Juan P. de Torres, José María Marín, Cristina Martínez-González, Antonia Fuster, Borja G. Cosío, Germán Peces-Barba, Ingrid Solanes, Nuria Feu-Collado, Jose Luis Lopez-Campos and Ciro Casanova

    Citation: Respiratory Research 2021 22:36

    Content type: Research

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  5. Although the prevalence of bronchial asthma has been increasing worldwide since the 1970′s, the prevalence among 5-year-old children was significantly lower in 2016 than in 2001 in rural Bangladesh. We aimed t...

    Authors: Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata and Md Alfazal Khan

    Citation: Respiratory Research 2021 22:35

    Content type: Research

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  6. The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypertension (PAH). Treatment interruptions should be avoided due to the progressive nature of the disease. ...

    Authors: Hans Klose, Kelly M. Chin, Ralf Ewert, Henning Gall, Joseph Parambil, David Poch, Hans-Jürgen Seyfarth, Lene N. Axelsen, Shu-Fang Hsu Schmitz, Claudia Stein and Ioana R. Preston

    Citation: Respiratory Research 2021 22:34

    Content type: Research

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  7. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) carry significant morbidity and mortality. AECOPD treatment remains limited. High molecular weight hyaluronan (HMW-HA) is a glycosaminoglyc...

    Authors: Flavia Galdi, Claudio Pedone, Christopher A. McGee, Margaret George, Annette B. Rice, Shah S. Hussain, Kadambari Vijaykumar, Evan R. Boitet, Guillermo J. Tearney, John A. McGrath, Audrey R. Brown, Steven M. Rowe, Raffaele A. Incalzi and Stavros Garantziotis

    Citation: Respiratory Research 2021 22:30

    Content type: Research

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  8. Pulmonary rehabilitation (PR) has been proposed as an effective method for many respiratory diseases. However, the effects of exercise-based PR on asthma are currently inconclusive. This review aimed to invest...

    Authors: Zhenzhen Feng, Jiajia Wang, Yang Xie and Jiansheng Li

    Citation: Respiratory Research 2021 22:33

    Content type: Review

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  9. Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of S...

    Authors: Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Ellen Pierre de Oliveira, Jose Mara de Brito, Ellen Caroline Toledo do Nascimento, Renata Aparecida de Almeida Monteiro, Juliana Carvalho Ferreira, Carlos Roberto Ribeiro de Carvalho, Paulo Hilário do Nascimento Saldiva and Marisa Dolhnikoff

    Citation: Respiratory Research 2021 22:32

    Content type: Research

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  10. Epithelial solitary chemosensory cell (tuft cell) bitter taste signal transduction occurs through G protein coupled receptors and calcium-dependent signaling pathways. Type II taste cells, which utilize the sa...

    Authors: Michael A. Kohanski, Lauren Brown, Melissa Orr, Li Hui Tan, Nithin D. Adappa, James N. Palmer, Ronald C. Rubenstein and Noam A. Cohen

    Citation: Respiratory Research 2021 22:31

    Content type: Research

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  11. Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is rel...

    Authors: Laurent Truffaut, Lucas Demey, Anne Violette Bruyneel, Alain Roman, Stephane Alard, Nathalie De Vos and Marie Bruyneel

    Citation: Respiratory Research 2021 22:29

    Content type: Letter to the Editor

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  12. Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...

    Authors: Thomas Sonnweber, Eva-Maria Schneider, Manfred Nairz, Igor Theurl, Günter Weiss, Piotr Tymoszuk and Judith Löffler-Ragg

    Citation: Respiratory Research 2021 22:28

    Content type: Research

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  13. Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral ...

    Authors: Alexandra Arvanitaki, George Giannakoulas, Eva Triantafyllidou, Christos Feloukidis, Afroditi K. Boutou, Alexandros Garyfallos, Haralambos Karvounis and Theodoros Dimitroulas

    Citation: Respiratory Research 2021 22:27

    Content type: Research

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  14. The epithelial-mesenchymal signaling involving SHH-FOXF1, TBX4-FGF10, and TBX2 pathways is an essential transcriptional network operating during early lung organogenesis. However, precise regulatory interactio...

    Authors: Justyna A. Karolak, Tomasz Gambin, Przemyslaw Szafranski and Paweł Stankiewicz

    Citation: Respiratory Research 2021 22:26

    Content type: Research

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  15. Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in ord...

    Authors: Helgo Magnussen, Sarah Lucas, Therese Lapperre, Jennifer K. Quint, Ronald J. Dandurand, Nicolas Roche, Alberto Papi, David Price and Marc Miravitlles

    Citation: Respiratory Research 2021 22:25

    Content type: Research

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  16. When infected with Mycobacterium tuberculosis, only a small proportion of the population will develop active TB, and the role of host genetic factors in different TB infection status was not fully understood.

    Authors: Jing-Wen Ai, Hanyue Zhang, Zumo Zhou, Shanshan Weng, Heqing Huang, Sen Wang, Lingyun Shao, Yan Gao, Jing Wu, Qiaoling Ruan, Feifei Wang, Ning Jiang, Jiazhen Chen and Wenhong Zhang

    Citation: Respiratory Research 2021 22:23

    Content type: Research

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  17. Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary disease (COPD). Our previous studies have validated N...

    Authors: Dan-dan Zong, Xiang-ming Liu, Jin-hua Li, Ruo-yun Ouyang, Ying-jiao Long, Ping Chen and Yan Chen

    Citation: Respiratory Research 2021 22:22

    Content type: Research

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  18. COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVI...

    Authors: Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni, John C. Marshall and Michael A. Portman

    Citation: Respiratory Research 2021 22:20

    Content type: Research

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  19. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, ...

    Authors: Rachel Lam, Sophia Kwon, Jessica Riggs, Maria Sunseri, George Crowley, Theresa Schwartz, Rachel Zeig-Owens, Hilary Colbeth, Allison Halpren, Mengling Liu, David J. Prezant and Anna Nolan

    Citation: Respiratory Research 2021 22:19

    Content type: Research

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  20. Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship be...

    Authors: Toru Shirahata, Hideaki Sato, Sanehiro Yogi, Kaiji Inoue, Mamoru Niitsu, Tomoe Akagami, Machika Soma, Tomohiko Mio, Makoto Nagata, Satoshi Nakae, Yuki Nishida, Shigeho Tanaka, Fuminori Katsukawa and Hidetoshi Nakamura

    Citation: Respiratory Research 2021 22:18

    Content type: Research

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  21. For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the re...

    Authors: Marie-Caroline Rotty, Carey M. Suehs, Jean-Pierre Mallet, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Fanny Bertelli, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel

    Citation: Respiratory Research 2021 22:17

    Content type: Research

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  22. Some studies investigated epidemiological and clinical features of laboratory-confirmed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus causing coronavirus disease 2019 (CO...

    Authors: Giovanna E. Carpagnano, Giovanni Migliore, Salvatore Grasso, Vito Procacci, Emanuela Resta, Francesco Panza and Onofrio Resta

    Citation: Respiratory Research 2021 22:16

    Content type: Research

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  23. Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of asthmatics older than 70 years old as compared to younger pat...

    Authors: F. Schleich, S. Graff, F. Guissard, M. Henket, V. Paulus and R. Louis

    Citation: Respiratory Research 2021 22:15

    Content type: Research

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  24. In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, ...

    Authors: Flora Lemaire, Sandra Audonnet, Jeanne-Marie Perotin, Pierre Gaudry, Sandra Dury, Julien Ancel, François Lebargy, Frank Antonicelli, Gaëtan Deslée and Richard Le Naour

    Citation: Respiratory Research 2021 22:14

    Content type: Research

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  25. It is essential to avoid admission of patients with undetected corona virus disease 2019 (COVID-19) to hospitals’ general wards. Even repeated negative reverse transcription polymerase chain reaction (RT-PCR) ...

    Authors: Ulf Teichgräber, Amer Malouhi, Maja Ingwersen, Rotraud Neumann, Marina Reljic, Stefanie Deinhardt-Emmer, Bettina Löffler, Wilhelm Behringer, Jan-Christoph Lewejohann, Andreas Stallmach and Philipp Reuken

    Citation: Respiratory Research 2021 22:13

    Content type: Research

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  26. In their letter-to-the-editor entitled “Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19”, Tobin et al. (Respir Res 21:249, 2020) debated our views on happy hypo...

    Authors: Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt and Bart N. Lambrecht

    Citation: Respiratory Research 2021 22:12

    Content type: Letter to the Editor

    Published on:

    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:249

    The Review to this article has been published in Respiratory Research 2020 21:198

  27. For antibiotic treatment of Acute exacerbations of COPD (AECOPD) the National guidelines in Denmark recommend either first choice amoxicillin 750 mg TID (AMX) or amoxicillin with clavulanic acid 500 mg/125 mg ...

    Authors: Kristian Bagge, Pradeesh Sivapalan, Josefin Eklöf, Frederik Böetius Hertz, Christian Østergaard Andersen, Ejvind Frausing Hansen, Jens Otto Jarløv and Jens-Ulrik Stæhr Jensen

    Citation: Respiratory Research 2021 22:11

    Content type: Research

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  28. Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are nee...

    Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock and Kian Fan Chung

    Citation: Respiratory Research 2021 22:10

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2021 22:47

  29. It is important to identify deterioration in normotensive patients with acute pulmonary embolism (PE). This study aimed to develop a tool for predicting deterioration among normotensive patients with acute PE ...

    Authors: Yizhuo Gao, Chao Ji, Hongyu Zhao, Jun Han, Haitao Shen and Dong Jia

    Citation: Respiratory Research 2021 22:9

    Content type: Research

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  30. Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulat...

    Authors: Heshen Tian, Lei Liu, Ying Wu, Ruiwen Wang, Yongliang Jiang, Ruicheng Hu, Liming Zhu, Linwei Li, Yanyan Fang, Chulan Yang, Lianzhi Ji, Guoyu Liu and Aiguo Dai

    Citation: Respiratory Research 2021 22:8

    Content type: Research

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  31. Diabetes is a common comorbidity among patients with exacerbation of chronic obstructive pulmonary disease (AECOPD). Diabetes has been reported to be associated with length of stay (LOS), death, and cost among...

    Authors: Xihua Mao, Chen Liang, Hongtao Niu, Fen Dong, Ke Huang, Yahong Chen, Kewu Huang, Qingyuan Zhan, Yaowen Zhang, Yin Huang, Ting Yang and Chen Wang

    Citation: Respiratory Research 2021 22:7

    Content type: Research

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  32. Chronic sputum production in the general population is historically associated with clinical indices including male sex and smoking history. However, its relationship with gastroesophageal reflux disease (GERD...

    Authors: Chie Morimoto, Hisako Matsumoto, Tadao Nagasaki, Yoshihiro Kanemitsu, Yumi Ishiyama, Hironobu Sunadome, Tsuyoshi Oguma, Isao Ito, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Akio Niimi, Shigeo Muro, Fumihiko Matsuda, Kazuo Chin and Toyohiro Hirai

    Citation: Respiratory Research 2021 22:6

    Content type: Research

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  33. There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional ch...

    Authors: Jean Pastre, Scott Barnett, Inga Ksovreli, Jeannie Taylor, A. Whitney Brown, Oksana A. Shlobin, Kareem Ahmad, Vikramjit Khangoora, Shambhu Aryal, Christopher S. King and Steven D. Nathan

    Citation: Respiratory Research 2021 22:5

    Content type: Research

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  34. Happy hypoxemia is an unspecified definition that is used in COVID-19 patients to define hypoxemia without dyspnoea. Dyspnoea is a very complex symptom, and although hypoxemia can cause breathlessness, dyspnoe...

    Authors: Josuel Ora, Paola Rogliani, Mario Dauri and Denis O’Donnell

    Citation: Respiratory Research 2021 22:4

    Content type: Letter to the Editor

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  35. Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely be...

    Authors: Ya-Sian Chang, Siang-Jyun Tu, Yu-Chia Chen, Ting-Yuan Liu, Ya-Ting Lee, Ju-Chen Yen, Hsin-Yuan Fang and Jan-Gowth Chang

    Citation: Respiratory Research 2021 22:3

    Content type: Research

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  36. ALI/ARDS is a severe lung injury leading to refractory respiratory failure, accounting for high morbidity and mortality. However, therapeutic approaches are rather limited. Targeting long non-coding RNA MALAT1...

    Authors: Yaling Liu, Xiaodong Wang, Peiying Li, Yanhua Zhao, Liqun Yang, Weifeng Yu and Hong Xie

    Citation: Respiratory Research 2021 22:1

    Content type: Research

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  37. Thymosin β10 (TMSB10) has been reported to play a protumorigenic role in a majority of solid cancers. However, the existence of TMSB10 in immune microenvironment may contribute to the pathogenesis of lung aden...

    Authors: Jun Zeng, Xianggui Yang, Li Yang, Wancheng Li and Yaxin Zheng

    Citation: Respiratory Research 2020 21:328

    Content type: Research

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  38. Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.

    Authors: Ryota Dokuni, Tatsuya Nagano, Naoe Jimbo, Hiroki Sato, Tatsunori Kiriu, Yuichiro Yasuda, Masatsugu Yamamoto, Motoko Tachihara, Kazuyuki Kobayashi, Yoshimasa Maniwa and Yoshihiro Nishimura

    Citation: Respiratory Research 2020 21:331

    Content type: Research

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  39. Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway infl...

    Authors: Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht and Annelie F. Behndig

    Citation: Respiratory Research 2020 21:330

    Content type: Research

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  40. Acute lung injury (ALI) is a clinical syndrome with high morbidity and mortality, and severe pulmonary edema is one of the characteristics. Epithelial sodium channel (ENaC) located on the apical side of alveol...

    Authors: Honglei Zhang, Yan Ding, Yapeng Hou, Yanhong Liu, Zhiyu Zhou and Hongguang Nie

    Citation: Respiratory Research 2020 21:329

    Content type: Research

    Published on:

  41. Since the coronavirus disease 2019 (COVID-19) identified in Wuhan, Hubei, China in December 2019, it has been characterized as a pandemic by World Health Organization (WHO). It was reported that asymptomatic p...

    Authors: Chaojie Wei, Yufeng Yuan and Zhenshun Cheng

    Citation: Respiratory Research 2020 21:327

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:21

  42. Pulmonary infections are associated with a brisk inflammatory reaction to bacterial surface components. Lipopolysaccharides (LPS) trigger macrophage activation and release of mitochondrial metabolites that con...

    Authors: Sebastián A. Riquelme and Alice Prince

    Citation: Respiratory Research 2020 21:326

    Content type: Review

    Published on:

  43. Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of th...

    Authors: Longxiang Su, Zhongheng Zhang, Fanglan Zheng, Pan Pan, Na Hong, Chun Liu, Jie He, Weiguo Zhu, Yun Long and Dawei Liu

    Citation: Respiratory Research 2020 21:325

    Content type: Research

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  44. Noninvasive ventilation (NIV) represents an effective treatment for chronic respiratory failure. However, empirically determined NIV settings may not achieve optimal ventilatory support. Therefore, the efficac...

    Authors: Marjolaine Georges, Claudio Rabec, Elise Monin, Serge Aho, Guillaume Beltramo, Jean-Paul Janssens and Philippe Bonniaud

    Citation: Respiratory Research 2020 21:324

    Content type: Research

    Published on:

  45. The effects of triple therapy on gas trapping in COPD are not fully understood. We evaluated the effects of the long acting bronchodilator components of the extrafine single inhaler triple therapy beclometason...

    Authors: James Dean, Catalina Panainte, Naimat Khan and Dave Singh

    Citation: Respiratory Research 2020 21:323

    Content type: Research

    Published on:

  46. Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbiditi...

    Authors: Alyson W. Wong, Tae Yoon Lee, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Charlene D. Fell, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Gerard Cox, Andrew J. Halayko, Nathan Hambly, Helene Manganas, Mohsen Sadatsafavi, Pearce G. Wilcox, Teresa To…

    Citation: Respiratory Research 2020 21:322

    Content type: Research

    Published on:

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