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  1. A genetic predisposition can lead to the rare disease pulmonary arterial hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable PAH. However, as of today 15 further PAH genes have ...

    Authors: Christina A. Eichstaedt, Zoe Saßmannshausen, Memoona Shaukat, Ding Cao, Panagiota Xanthouli, Henning Gall, Natascha Sommer, Hossein-Ardeschir Ghofrani, Hans-Jürgen Seyfarth, Marianne Lerche, Michael Halank, Janina Kleymann, Nicola Benjamin, Satenik Harutyunova, Benjamin Egenlauf, Katrin Milger…
    Citation: Respiratory Research 2022 23:74
  2. For patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung damage. In this study, we investigated the role of NOX4 using NOX4 knock...

    Authors: Sang Hoon Lee, Mi Hwa Shin, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim and Moo Suk Park
    Citation: Respiratory Research 2022 23:73
  3. Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyreti...

    Authors: Astrid Monfort, Alexia Rivas, Rishika Banydeen, Jocelyn Inamo, Karim Farid and Remi Neviere
    Citation: Respiratory Research 2022 23:72
  4. Pneumonia is a major contributor to hospital admission for patients with chronic obstructive pulmonary disease (COPD). However, evidence for acute effects of ambient air pollution exposure on pneumonia hospita...

    Authors: Wenfeng Lu, Qi Tian, Ruijun Xu, Chenghui Zhong, Lan Qiu, Han Zhang, Chunxiang Shi, Yuewei Liu and Yun Zhou
    Citation: Respiratory Research 2022 23:71
  5. Particular matter 2.5 (PM2.5) is one of the most important air pollutant, and it is positively associated with the development of chronic obstructive pulmonary disease (COPD). However, the precise underlying m...

    Authors: Hongjiao Yu, Yingnan Lin, Yue Zhong, Xiaolan Guo, Yuyin Lin, Siqi Yang, Jinglin Liu, Xinran Xie, Yaowei Sun, Dong Wang, Bing Li, Pixin Ran and Jianwei Dai
    Citation: Respiratory Research 2022 23:70
  6. Chronic obstructive pulmonary disease (COPD) is a leading cause of death in adults that may have origins in early lung development. It is a complex disease, influenced by multiple factors including genetic var...

    Authors: Annika Röhl, Seung Han Baek, Priyadarshini Kachroo, Jarrett D. Morrow, Kelan Tantisira, Edwin K. Silverman, Scott T. Weiss, Amitabh Sharma, Kimberly Glass and Dawn L. DeMeo
    Citation: Respiratory Research 2022 23:69
  7. Patient hospitalized for coronavirus disease 2019 (COVID-19) pulmonary infection can have sequelae such as impaired exercise capacity. We aimed to determine the frequency of long-term exercise capacity limitat...

    Authors: Bruno Ribeiro Baptista, Thomas d’Humières, Frédéric Schlemmer, Inès Bendib, Grégoire Justeau, Lara Al-Assaad, Mouna Hachem, Rebecca Codiat, Benjamin Bardel, Laure Abou Chakra, Thibaut Belmondo, Etienne Audureau, Sophie Hue, Armand Mekontso-Dessap, Geneviève Derumeaux and Laurent Boyer
    Citation: Respiratory Research 2022 23:68
  8. The assessment of small airways obstruction (SAO) using spirometry is practiced in population-based studies. However, it is not clear what are the most used parameters and cut-offs to define abnormal results.

    Authors: Ben Knox-Brown, Octavia Mulhern, Johanna Feary and Andre F. S. Amaral
    Citation: Respiratory Research 2022 23:67
  9. Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 1...

    Authors: Paola Faverio, Fabrizio Luppi, Paola Rebora, Gabriele D’Andrea, Anna Stainer, Sara Busnelli, Martina Catalano, Giuseppe Modafferi, Giovanni Franco, Anna Monzani, Stefania Galimberti, Paolo Scarpazza, Elisa Oggionni, Monia Betti, Tiberio Oggionni, Federica De Giacomi…
    Citation: Respiratory Research 2022 23:65
  10. Ambient air pollution poses a major risk for the development and aggravation of respiratory diseases. Evidence suggests that even in low-level air pollution environments there is a risk for an increase in adve...

    Authors: Christina Hoffmann, Mariam Maglakelidze, Erika von Schneidemesser, Christian Witt, Peter Hoffmann and Tim Butler
    Citation: Respiratory Research 2022 23:64
  11.  Chronic obstructive pulmonary disease (COPD) is a significant public health concern. The patients with acute exacerbations of COPD (AECOPD) and pneumonia have similar clinical presentations. The use of conven...

    Authors: Chin-Wang Hsu, Chi-Won Suk, Yuan-Pin Hsu, Jer-Hwa Chang, Chung-Te Liu, Shau-Ku Huang and Shih-Chang Hsu
    Citation: Respiratory Research 2022 23:63
  12. Idiopathic pulmonary fibrosis (IPF) is a progressive form of fibrosing interstitial pneumonia with poor survival. This study provides insight into the epidemiology, cost, and disease course of IPF in Germany.

    Authors: Michael Kreuter, Nils Picker, Larissa Schwarzkopf, Severin Baumann, Agustin Cerani, Roelien Postema, Ulf Maywald, Axel Dittmar, Jonathan Langley and Haridarshan Patel
    Citation: Respiratory Research 2022 23:62
  13. Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited treatment options. A phase 2 trial (NCT01766817) showed that twice-daily treatment with BMS-986020, a lysophosphatidic acid recep...

    Authors: Benjamin E. Decato, Diana Julie Leeming, Jannie Marie Bülow Sand, Aryeh Fischer, Shuyan Du, Scott M. Palmer, Morten Karsdal, Yi Luo and Anne Minnich
    Citation: Respiratory Research 2022 23:61
  14. PAP is an ultra-rare respiratory syndrome characterized by the accumulation of surfactant within the alveoli. Whole lung lavage (WLL) is the current standard of care of PAP, however it is not a standardized pr...

    Authors: Francesca Mariani, Elena Salvaterra, Sara Lettieri, Annalisa De Silvestri, Alessandra Corino, Matteo Bosio, Elia Fraolini, Davide Piloni, Giuseppe Rodi, Angelo Guido Corsico and Ilaria Campo
    Citation: Respiratory Research 2022 23:60
  15. Comorbidities are common in interstitial lung diseases (ILD) and have an important association with survival, but the frequency and prognostic impact of comorbidities in unclassifiable interstitial lung diseas...

    Authors: Thomas Skovhus Prior, Charlotte Hyldgaard, Sebastiano Emanuele Torrisi, Sissel Kronborg-White, Claudia Ganter, Elisabeth Bendstrup and Michael Kreuter
    Citation: Respiratory Research 2022 23:59
  16. Unfortunately, many COPD patients continue to exacerbate despite good adherence to GOLD Class D recommended therapy. Acute exacerbations lead to an increase in symptoms, decline in lung function and increased ...

    Authors: Michelle Brennan, M. J. McDonnell, M. J. Harrison, N. Duignan, A. O’Regan, D. M. Murphy, C. Ward and R. M. Rutherford
    Citation: Respiratory Research 2022 23:58
  17. Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD), like those with idiopathic pulmonary fibrosis (IPF), might develop an unexpected acute exacerbation (AE)—a rapidly progressing ...

    Authors: Hironao Hozumi, Masato Kono, Hirotsugu Hasegawa, Shinpei Kato, Yusuke Inoue, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Koshi Yokomura, Hidenori Nakamura and Takafumi Suda
    Citation: Respiratory Research 2022 23:57
  18. Coronavirus disease (COVID-19) responses such as social distancing practices can decrease health care access and tuberculosis (TB) notification, particularly among individuals aged 60 years or older. Conversel...

    Authors: Honghyok Kim, Young Ae Kang, Hee-Jin Kim and Hongjo Choi
    Citation: Respiratory Research 2022 23:56
  19. Increased elastase activity in α1-antitrypsin deficiency may affect elasticity of the arterial walls, and thereby blood pressure and susceptibility to cardiovascular disease. We hypothesized that severe α1-antitr...

    Authors: Sine Voss Winther, Dunia Ahmed, Suzan Al-Shuweli, Eskild Morten Landt, Børge Grønne Nordestgaard, Niels Seersholm and Morten Dahl
    Citation: Respiratory Research 2022 23:55
  20. Infliximab is a monoclonal antibody that binds and neutralizes circulating tumor necrosis factor-alpha, a key inflammatory cytokine in the pathophysiology of sarcoidosis. Despite the paucity of randomized clin...

    Authors: Abdullah Sakkat, Gerard Cox, Nader Khalidi, Maggie Larche, Karen Beattie, Elisabetta A. Renzoni, Nilesh Morar, Vasilis Kouranos, Martin Kolb and Nathan Hambly
    Citation: Respiratory Research 2022 23:54
  21. Chronic obstructive pulmonary disease (COPD) patients with a body mass index (BMI) < 25 kg/m2 are prone to develop adverse event of pharmacological treatment for frequent exacerbation. As chronic bronchitis (CB) ...

    Authors: Sun Hye Shin, Sung Ok Kwon, Victor Kim, Edwin Kepner Silverman, Tae-Hyung Kim, Deog Kyeom Kim, Yong Il Hwang, Kwang Ha Yoo, Woo Jin Kim and Hye Yun Park
    Citation: Respiratory Research 2022 23:52
  22. A subset of individuals with allergic asthma develops a late phase response (LPR) to inhaled allergens, which is characterized by a prolonged airway obstruction, airway inflammation and airway hyperresponsiven...

    Authors: Maria Weitoft, Måns Kadefors, Henning Stenberg, Ellen Tufvesson, Zuzana Diamant, Sara Rolandsson Enes, Leif Bjermer, Oskar Rosmark and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2022 23:50
  23. Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil...

    Authors: Marc Miravitlles, Juan José Soler-Cataluña, Joan B. Soriano, Francisco García-Río, Pilar de Lucas, Inmaculada Alfageme, Ciro Casanova, José Miguel Rodríguez González-Moro, M. Guadalupe Sánchez-Herrero, Julio Ancochea and Borja G. Cosío
    Citation: Respiratory Research 2022 23:49
  24. The prevalence of allergic respiratory disease (ARD) is increasing worldwide during the last few decades, causing a great disease burden especially for children. Air pollution has been increasingly considered ...

    Authors: Junyang Li, Yabin Hu, Huaiyuan Li, Yihang Lin, Shilu Tong and Youjin Li
    Citation: Respiratory Research 2022 23:48
  25. High-resolution computed tomography (HRCT) is recommended diagnosing and monitoring connective tissue disease-associated interstitial lung disease (CTD-ILD). Quantitative computed tomography has the potential ...

    Authors: Ling Chen, Min Zhu, Haiyan Lu, Ting Yang, Wanjiang Li, Yali Zhang, Qibing Xie, Zhenlin Li, Huajing Wan and Fengming Luo
    Citation: Respiratory Research 2022 23:47
  26. Whether the COVID-19 pandemic impacts Positive Airway Pressure (PAP) adherence over the long-term is unknown and only preliminary short-term data have been reported.

    Authors: Fanny Bertelli, Carey M. Suehs, Jean-Pierre Mallet, Isabelle Court-Fortune, Frédéric Gagnadoux, Jean Christian Borel, Olivier Gaubert, Nicolas Molinari, Arnaud Bourdin and Dany Jaffuel
    Citation: Respiratory Research 2022 23:46
  27. Long-term use of oral corticosteroids (OCS) is associated with a risk of adverse events and comorbidities. As such, a goal in assessing the efficacy of biologics in severe asthma is often to monitor reduction ...

    Authors: Stephanie Korn, Peter Howarth, Steven G. Smith, Robert G. Price, Steven W. Yancey, Charlene M. Prazma and Elisabeth H. Bel
    Citation: Respiratory Research 2022 23:45
  28. Chronic obstructive pulmonary disease (COPD) is among the top 5 causes of mortality in the world and can develop as a consequence of genetic and/or environmental factors. Current efforts are focused on identif...

    Authors: Sanja Blaskovic, Yves Donati, Isabelle Ruchonnet-Metrailler, Yannick Avila, Dominik Schittny, Christian Matthias Schlepütz, Johannes Constantin Schittny and Constance Barazzone-Argiroffo
    Citation: Respiratory Research 2022 23:44
  29. The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world. We previously identified a gene signatu...

    Authors: M. de Vries, K. O. Nwozor, K. Muizer, M. Wisman, W. Timens, M. van den Berge, A. Faiz, T.-L. Hackett, I. H. Heijink and C. A. Brandsma
    Citation: Respiratory Research 2022 23:43
  30. Intermittent hypoxia induces increased ventilatory responses in a 5-HT-dependent manner. This study aimed to explore that effect of raphe magnus serotonin 1A receptor (5-HT1A) receptor on the increased ventilator...

    Authors: Jiao Su, Yang Meng, Yifei Fang, Linge Sun, Mengge Wang, Yanjun Liu, Chunling Zhao, Liping Dai and Songyun Ouyang
    Citation: Respiratory Research 2022 23:42
  31. Cigarette smoke (CS) is associated with chronic obstructive pulmonary disease (COPD) and cancer. However, the underlying pathological mechanisms are not well understood. We recently reported that mice exposed ...

    Authors: Hidehiro Irie, Mari Ozaki, Shotaro Chubachi, Ahmed E. Hegab, Akihiro Tsutsumi, Naofumi Kameyama, Kaori Sakurai, Shingo Nakayama, Shizuko Kagawa, Sachika Wada, Makoto Ishii, Tomoko Betsuyaku and Koichi Fukunaga
    Citation: Respiratory Research 2022 23:41
  32. In chronic obstructive pulmonary disease (COPD), exacerbations cause acute inflammatory flare-ups and increase the risk for hospitalization and mortality. Exacerbations are common in all disease stages and are...

    Authors: Jef Serré, Ajime Tom Tanjeko, Carolien Mathyssen, Tobias Heigl, Annelore Sacreas, Dana Paulina Cook, Erik Verbeken, Karen Maes, Jan Verhaegen, Charles Pilette, Jeroen Vanoirbeek, Conny Gysemans, Chantal Mathieu, Bart Vanaudenaerde, Wim Janssens and Ghislaine Gayan-Ramirez
    Citation: Respiratory Research 2022 23:40
  33. Recent studies have demonstrated that airway basal stem cells (BCs) transplantation can ameliorate bleomycin-induced idiopathic pulmonary fibrosis (IPF) through lung regeneration promotion. However, BCs under ...

    Authors: Huanbin Liu, Shuna Liu, Jinjun Jiang, Yidi Zhang, Yulong Luo, Jingxin Zhao, Jian Xu, Yuan Xie, Weiping Liao, Wei Wang, Yichu Nie, Shiyue Li and Wenbin Deng
    Citation: Respiratory Research 2022 23:39
  34. Studies on the associations between ambient temperature and asthma hospitalizations are limited, and the results are controversial. We aimed to assess the short-term effects of ambient temperature on the risk ...

    Authors: Yuxiong Chen, Dehui Kong, Jia Fu, Yongqiao Zhang, Yakun Zhao, Yanbo Liu, Zhen’ge Chang, Yijie Liu, Xiaole Liu, Kaifeng Xu, Chengyu Jiang and Zhongjie Fan
    Citation: Respiratory Research 2022 23:38
  35. Some COVID-19 survivors present lung function abnormalities during follow-up, particularly reduced carbon monoxide lung diffusing capacity (DLCO). To investigate risk factors and underlying pathophysiology, we...

    Authors: Oriol Sibila, Lídia Perea, Núria Albacar, Jorge Moisés, Tamara Cruz, Núria Mendoza, Belen Solarat, Gemma Lledó, Gerard Espinosa, Joan Albert Barberà, Joan Ramon Badia, Alvar Agustí, Jacobo Sellarés and Rosa Faner
    Citation: Respiratory Research 2022 23:37
  36. Data from phase 3 trials have demonstrated the efficacy and safety of benralizumab in patients with severe eosinophilic asthma (SEA). We conducted a real-world study examining the baseline characteristics of a...

    Authors: Francesco Menzella, Elena Bargagli, Maria Aliani, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Cristiano Caruso, Stefano Centanni, Maria D’Amato, Stefano Del Giacco, Fausto De Michele, Fabiano Di Marco, Elide Anna Pastorello, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli…
    Citation: Respiratory Research 2022 23:36
  37. Lung inhomogeneity plays a pivotal role in the development of ventilator-induced lung injury (VILI), particularly in the context of pre-existing lung injury. The mechanisms that underlie this interaction are p...

    Authors: Yong Song, Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Andreas Fouras, Peter A. Dargaville and Graeme R. Zosky
    Citation: Respiratory Research 2022 23:35
  38. Whether restricted spirometry, i.e. low Forced Vital Capacity (FVC), predicts chronic cardiometabolic disease is not definitely known. In this international population-based study, we assessed the relationship...

    Authors: Katarzyna Kulbacka-Ortiz, Filip J. J. Triest, Frits M. E. Franssen, Emiel F. M. Wouters, Michael Studnicka, William M. Vollmer, Bernd Lamprecht, Peter G. J. Burney, Andre F. S. Amaral and Lowie E. G. W. Vanfleteren
    Citation: Respiratory Research 2022 23:34
  39. Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease with a complex pathogenesis and high mortality. The development of new drugs is time-consuming and laborious; therefore, research on t...

    Authors: Cailing Gan, Qianyu Zhang, Hongyao Liu, Guan Wang, Liqun Wang, Yali Li, Zui Tan, Wenya Yin, Yuqin Yao, Yongmei Xie, Liang Ouyang, Luoting Yu and Tinghong Ye
    Citation: Respiratory Research 2022 23:32
  40. Toll-interacting protein (Tollip) is one of the key negative regulators in host innate immunity. Genetic variation of Tollip has been associated with less Tollip expression and poor lung function in asthmatic ...

    Authors: Niccolette Schaunaman, Kris Genelyn Dimasuay, Monica Kraft and Hong Wei Chu
    Citation: Respiratory Research 2022 23:31
  41. Profiles of people with chronic obstructive pulmonary disease (COPD) often do not describe treatable traits, lack validation and/or their stability over time is unknown. We aimed to identify COPD profiles and ...

    Authors: Alda Marques, Sara Souto-Miranda, Ana Machado, Ana Oliveira, Cristina Jácome, Joana Cruz, Vera Enes, Vera Afreixo, Vitória Martins, Lília Andrade, Carla Valente, Diva Ferreira, Paula Simão, Dina Brooks and Ana Helena Tavares
    Citation: Respiratory Research 2022 23:30
  42. Chest computed tomography (CT) is a widely used method to assess morphological and dynamic abnormalities in chronic obstructive pulmonary disease (COPD). The small pulmonary vascular cross-section (CSA), quant...

    Authors: Sang Won Park, Myoung-Nam Lim, Woo Jin Kim and So Hyeon Bak
    Citation: Respiratory Research 2022 23:29
  43. Coronary artery disease (CAD) is a common comorbidity of chronic obstructive pulmonary disease (COPD). However, data related to the impact of CAD on outcomes of acute exacerbation of COPD (AECOPD) are limited ...

    Authors: Yanan Cui, Zijie Zhan, Yiming Ma, Ke Huang, Chen Liang, Xihua Mao, Yaowen Zhang, Xiaoxia Ren, Jieping Lei, Yan Chen, Ting Yang and Chen Wang
    Citation: Respiratory Research 2022 23:28
  44. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease. Currently, the diagnosis of AECOPD mainly relies on clinical manifestatio...

    Authors: Huijie Wang, Yonghong Zhong, Na Li, Min Yu, Lin Zhu, Lina Wang, Fei Chen, Yaping Xu, Jian Liu and Huaqiong Huang
    Citation: Respiratory Research 2022 23:27
  45. Pulmonary hyperinflammation is a key event with SARS-CoV-2 infection. Acute respiratory distress syndrome (ARDS) that often accompanies COVID-19 appears to have worse outcomes than ARDS from other causes. To d...

    Authors: Oindrila Paul, Jian Qin Tao, Eric West, Leslie Litzky, Michael Feldman, Kathleen Montone, Chamith Rajapakse, Christian Bermudez and Shampa Chatterjee
    Citation: Respiratory Research 2022 23:25

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