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Respiratory Research

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  1. Content type: Research

    Clinical audits have reported considerable variability in COPD medical care and frequent inconsistencies with recommendations. The objectives of this study were to identify factors associated with a better adh...

    Authors: Myriam Calle Rubio, José Luis López-Campos, Juan J. Soler-Cataluña, Bernardino Alcázar Navarrete, Joan B. Soriano, José Miguel Rodríguez González-Moro, Manuel E. Fuentes Ferrer and Juan Luis Rodríguez Hermosa

    Citation: Respiratory Research 2017 18:200

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  2. Content type: Research

    Asthma is characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and airway remodeling. While exposure of house dust mites (HDM) is a common cause of asthma, the pathogenesis of the HD...

    Authors: Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu and Zhou Fu

    Citation: Respiratory Research 2017 18:199

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  3. Content type: Research

    Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive ...

    Authors: Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki and Péter Engelmann

    Citation: Respiratory Research 2017 18:197

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  4. Content type: Review

    According to the current clinical practice guidelines for chronic obstructive pulmonary disease (COPD), the addition of inhaled corticosteroids (ICS) to long-acting β2 agonist therapy is recommended in patients w...

    Authors: Marc Miravitlles, Borja G. Cosío, Aurelio Arnedillo, Myriam Calle, Bernardino Alcázar-Navarrete, Cruz González, Cristóbal Esteban, Juan Antonio Trigueros, José Miguel Rodríguez González-Moro, José Antonio Quintano Jiménez and Adolfo Baloira

    Citation: Respiratory Research 2017 18:198

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  5. Content type: Research

    Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodate...

    Authors: Marc Miravitlles, Gerard Urrutia, Alexander G. Mathioudakis and Julio Ancochea

    Citation: Respiratory Research 2017 18:196

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  6. Content type: Research

    The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling...

    Authors: Shinkichi Ishikawa, Kanae Ishimori and Shigeaki Ito

    Citation: Respiratory Research 2017 18:195

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  7. Content type: Research

    Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of cor...

    Authors: Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo and Kian Fan Chung

    Citation: Respiratory Research 2017 18:194

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  8. Content type: Research

    Despite their growing popularity, the potential respiratory toxicity of electronic cigarettes (e-cigarettes) remains largely unknown. One potential aspect of e-cigarette toxicity is the effect of e-cigarette v...

    Authors: Rebecca J. Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya and Amir M. Farnoud

    Citation: Respiratory Research 2017 18:193

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  9. Content type: Research

    Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsibl...

    Authors: Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq and Philippe Gosset

    Citation: Respiratory Research 2017 18:191

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  10. Content type: Commentary

    Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more re...

    Authors: Ianthe Piscaer, Emiel F. M. Wouters, Cees Vermeer, Wim Janssens, Frits M. E. Franssen and Rob Janssen

    Citation: Respiratory Research 2017 18:189

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  11. Content type: Letter to the Editor

    The main symptoms of patients with idiopathic pulmonary fibrosis (IPF) are cough and dyspnea. IPF leads to a restrictive lung disorder impacting daytime and nocturnal breathing patterns. In this pilot study we...

    Authors: Anke Schertel, Manuela Funke-Chambour, Thomas Geiser and Anne-Kathrin Brill

    Citation: Respiratory Research 2017 18:190

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  12. Content type: Research

    The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and conse...

    Authors: Stephane Esnault, Ksenija Bernau, Elizabeth E. Torr, Yury A. Bochkov, Nizar N. Jarjour and Nathan Sandbo

    Citation: Respiratory Research 2017 18:188

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  13. Content type: Research

    Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to respond to standard vasodilator therapy tar...

    Authors: Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel and Robbert J. Rottier

    Citation: Respiratory Research 2017 18:187

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  14. Content type: Research

    Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of cope...

    Authors: Jacob A. Winther, Jon Brynildsen, Arne Didrik Høiseth, Heidi Strand, Ivar Følling, Geir Christensen, Ståle Nygård, Helge Røsjø and Torbjørn Omland

    Citation: Respiratory Research 2017 18:184

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  15. Content type: Research

    Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, wh...

    Authors: Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva and Patricia Rieken Macedo Rocco

    Citation: Respiratory Research 2017 18:185

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  16. Content type: Research

    Revefenacin is a once-daily long-acting muscarinic antagonist (LAMA) in clinical development for the treatment of patients with chronic obstructive pulmonary disease (COPD). In a dose-ranging study, nebulized ...

    Authors: Krishna K. Pudi, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Edward Kerwin

    Citation: Respiratory Research 2017 18:182

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  17. Content type: Letter to the Editor

    Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the ...

    Authors: Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp…

    Citation: Respiratory Research 2017 18:181

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  18. Content type: Research

    Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in...

    Authors: Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P. Comellas, Prescott Woodruff, Wanda O’Neal, Dawn L. DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J. Castaldi, Craig Hersh, Edwin K. Silverman, James D. Crapo, Katerina Kechris and Russell P. Bowler

    Citation: Respiratory Research 2017 18:180

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  19. Content type: Research

    Bilirubin is a potent anti-oxidant and higher serum concentrations of bilirubin have been associated with better lung function, slower lung function decline, and lower incidence of chronic obstructive pulmonar...

    Authors: Kirstin E. Brown, Don D. Sin, Helen Voelker, John E. Connett, Dennis E. Niewoehner and Ken M. Kunisaki

    Citation: Respiratory Research 2017 18:179

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  20. Content type: Research

    Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of th...

    Authors: Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang and Pau-Chung Chen

    Citation: Respiratory Research 2017 18:178

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  21. Content type: Research

    Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome (ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-induced vascular injury. Recently, endothelial...

    Authors: Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi and James West

    Citation: Respiratory Research 2017 18:177

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  22. Content type: Research

    Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate fact...

    Authors: Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, Tomás Posadas, Laia Fernández-Barat and Antoni Torres

    Citation: Respiratory Research 2017 18:176

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