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  1. Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study p...

    Authors: Spyros A. Papiris, Panagiotis Tsirigotis, Caroline Kannengiesser, Lykourgos Kolilekas, Konstantinos Gkirkas, Andriana I. Papaioannou, Patrick Revy, Paschalina Giouleka, Georgia Papadaki, Konstantinos Kagouridis, Vassiliki Pappa, Raphael Borie, Catherine Boileau, Demosthenes Bouros, Bruno Crestani and Effrosyni D. Manali

    Citation: Respiratory Research 2019 20:182

    Content type: Letter to the Editor

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  2. KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

    Authors: Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat, Sarah L. O’Beirne, Robert J. Kaner, Jason G. Mezey, Haijun Zhang, Philip L. Leopold and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:181

    Content type: Research

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  3. CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmon...

    Authors: Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni and Marie Anna Nandeuil

    Citation: Respiratory Research 2019 20:180

    Content type: Research

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  4. Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, ...

    Authors: Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller and Hui Cao

    Citation: Respiratory Research 2019 20:178

    Content type: Research

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  5. Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesio...

    Authors: Kyu Min Lee, Geewon Lee, Ahreum Kim, Jeongha Mok, Ji Won Lee, Yeon Joo Jeong, Eun-Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee and Jung Seop Eom

    Citation: Respiratory Research 2019 20:177

    Content type: Research

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  6. Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obs...

    Authors: Hiroto Takiguchi, Virginia Chen, Ma’en Obeidat, Zsuzsanna Hollander, J. Mark FitzGerald, Bruce M. McManus, Raymond T. Ng and Don D. Sin

    Citation: Respiratory Research 2019 20:176

    Content type: Research

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  7. The amount of surfactant deposited in the lungs and its overall pulmonary distribution determine the therapeutic outcome of surfactant replacement therapy. Most of the currently available methods to determine ...

    Authors: Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Francesca Ricci, Francesca Boscaro, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Federico Bianco, Fabrizio Salomone, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp and Alan H. Jobe

    Citation: Respiratory Research 2019 20:175

    Content type: Research

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  8. Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

    Authors: Xu Liu, Mei Mei, Xiang Chen, Yulan Lu, Xinran Dong, Liyuan Hu, Xiaojing Hu, Guoqiang Cheng, Yun Cao, Lin Yang and Wenhao Zhou

    Citation: Respiratory Research 2019 20:174

    Content type: Research

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  9. Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

    Authors: David A. Leather, Louisa Yates, Henrik Svedsater, Loretta Jacques, Susan Collier, Danielle Powell and Rupert Jones

    Citation: Respiratory Research 2019 20:173

    Content type: Commentary

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  10. Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

    Authors: Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall and Ian Sayers

    Citation: Respiratory Research 2019 20:172

    Content type: Research

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  11. Metabolic adaptation in immune cells is necessary to modulate immune cell function as it is intricately coupled with intracellular metabolism. We aimed to characterize the metabolic state of human peripheral b...

    Authors: Amit R Agarwal, Smita Kadam, Ankita Brahme, Manas Agrawal, Komalkirti Apte, Govinda Narke, Kushal Kekan, Sapna Madas and Sundeep Salvi

    Citation: Respiratory Research 2019 20:171

    Content type: Research

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  12. Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

    Authors: Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro and Mona Bafadhel

    Citation: Respiratory Research 2019 20:170

    Content type: Research

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  13. We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

    Authors: Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey and Namhee Kwon

    Citation: Respiratory Research 2019 20:169

    Content type: Research

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  14. Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosi...

    Authors: Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert Guzy, Gökhan M. Mutlu and Nickolai O. Dulin

    Citation: Respiratory Research 2019 20:168

    Content type: Research

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  15. Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate...

    Authors: Edward M. Kerwin, Gary T. Ferguson, Mindy Mo, Kiernan DeAngelis and Paul Dorinsky

    Citation: Respiratory Research 2019 20:167

    Content type: Research

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  16. Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in card...

    Authors: Yousef S. Aldabayan, Heidi A. Ridsdale, Ahmed M. Alrajeh, Abdulelah M. Aldhahir, Arthur Lemson, Jaber S. Alqahtani, Jeremy S. Brown and John R. Hurst

    Citation: Respiratory Research 2019 20:166

    Content type: Research

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  17. Complement factor C5 can either aggravate or attenuate the T-helper type 2 (TH2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phas...

    Authors: Jack Yang, Ivan Ramirez Moral, Cornelis van ’t Veer, Alex F. de Vos, Regina de Beer, Joris J. T. H. Roelofs, B. Paul Morgan and Tom van der Poll

    Citation: Respiratory Research 2019 20:165

    Content type: Research

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  18. Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about t...

    Authors: Yang Zhang, Yuanyuan Zeng, Ting Liu, Wenwen Du, Jianjie Zhu, Zeyi Liu and Jian-an Huang

    Citation: Respiratory Research 2019 20:164

    Content type: Research

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  19. Pulmonary fibrosis is a progressive and irreversible disease for which therapeutic options are currently limited. A recent in vivo study showed that tenofovir, a nucleotide analogue reverse transcriptase inhib...

    Authors: Lingxia Li, Jing Zhao, Li Zhou, Jie Chen, Yuanyuan Ma, Yanyan Yu and Jun Cheng

    Citation: Respiratory Research 2019 20:163

    Content type: Research

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  20. Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessari...

    Authors: Guanghui Liu, Catherine Betts, Danen M. Cunoosamy, Per M. Åberg, Jorrit J. Hornberg, Kinga Balogh Sivars and Taylor S. Cohen

    Citation: Respiratory Research 2019 20:162

    Content type: Review

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  21. Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS)...

    Authors: Woori Kim, Michael H. Cho, Phuwanat Sakornsakolpat, David A. Lynch, Harvey O. Coxson, Ruth Tal-Singer, Edwin K. Silverman and Terri H. Beaty

    Citation: Respiratory Research 2019 20:160

    Content type: Research

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  22. The primary lung function endpoint in clinical trials in adolescent and adult patients with asthma is usually forced expiratory volume in one second (FEV1). The objective of our analysis was to assess whether pea...

    Authors: David M. G. Halpin, Eli O. Meltzer, Wendelgard Pisternick-Ruf, Petra Moroni-Zentgraf, Michael Engel, Liliana Zaremba-Pechmann, Thomas Casale and J. Mark FitzGerald

    Citation: Respiratory Research 2019 20:159

    Content type: Research

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  23. Respiratory Distress Syndrome (RDS) is a prematurity-related breathing disorder caused by a quantitative deficiency of pulmonary surfactant. Surfactant replacement therapy is effective for RDS newborns, althou...

    Authors: Sonia Giambelluca, Francesca Ricci, Manuela Simonato, Luca Vedovelli, Umberto Traldi, Alessio Correani, Costanza Casiraghi, Matteo Storti, Arianna Mersanne, Paola Cogo, Fabrizio Salomone and Virgilio P. Carnielli

    Citation: Respiratory Research 2019 20:158

    Content type: Research

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  24. Chronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship betwe...

    Authors: Balázs Csoma, András Bikov, Lajos Nagy, Bence Tóth, Tamás Tábi, Gergő Szűcs, Zsolt István Komlósi, Veronika Müller, György Losonczy and Zsófia Lázár

    Citation: Respiratory Research 2019 20:156

    Content type: Research

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  25. Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung i...

    Authors: Renata de S. Mendes, Milena V. Oliveira, Gisele A. Padilha, Nazareth N. Rocha, Cintia L. Santos, Ligia A. Maia, Marcos V. de S. Fernandes, Fernanda F. Cruz, Priscilla C. Olsen, Vera L. Capelozzi, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R. M. Rocco and Pedro L. Silva

    Citation: Respiratory Research 2019 20:155

    Content type: Research

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  26. Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study ...

    Authors: Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Daisuke Okuno, Hirokazu Yura, Shota Nakashima, Hiroshi Ishimoto, Takashi Kido, Daisuke Taniguchi, Takuro Miyazaki, Tomoshi Tsuchiya, Shin Tsutsui, Hiroyuki Yamaguchi, Yasushi Obase, Yuji Ishimatsu, Kazuto Ashizawa…

    Citation: Respiratory Research 2019 20:154

    Content type: Research

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  27. Quantitative computed tomographic (QCT) imaging-based metrics enable to quantify smoking induced disease alterations and to identify imaging-based clusters for current smokers. We aimed to derive clinically me...

    Authors: Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, Chang Hyun Lee, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup…

    Citation: Respiratory Research 2019 20:153

    Content type: Research

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  28. Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells relate within and between these two biological co...

    Authors: Tamara Cruz, Alejandra López-Giraldo, Guillaume Noell, Sandra Casas-Recasens, Tamara Garcia, Laureano Molins, Manel Juan, Marco A. Fernandez, Alvar Agustí and Rosa Faner

    Citation: Respiratory Research 2019 20:152

    Content type: Research

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  29. The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function o...

    Authors: Franziska C. Trudzinski, Mohamad Alqudrah, Albert Omlor, Stephen Zewinger, Danilo Fliser, Timotheus Speer, Frederik Seiler, Frank Biertz, Armin Koch, Claus Vogelmeier, Tobias Welte, Henrik Watz, Benjamin Waschki, Sebastian Fähndrich, Rudolf Jörres and Robert Bals

    Citation: Respiratory Research 2019 20:151

    Content type: Research

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  30. Human rhinovirus (HRV) infections are the primary cause of the common cold and are a major trigger for exacerbations of lower airway diseases, such as asthma and chronic obstructive pulmonary diseases. Althoug...

    Authors: Stephanie M. Warner, Shahina Wiehler, Aubrey N. Michi and David Proud

    Citation: Respiratory Research 2019 20:150

    Content type: Research

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  31. Supplemental oxygen therapy is widely used in hospitals and in the home for chronic care. However, there are several fundamental problems with the application of this therapy such that patients are often expos...

    Authors: Ira Katz, John Chen, Kelvin Duong, Kaixian Zhu, Marine Pichelin, Georges Caillibotte and Andrew R. Martin

    Citation: Respiratory Research 2019 20:149

    Content type: Research

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  32. Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying ...

    Authors: Louise A. Organ, Anne-Marie R. Duggan, Eunice Oballa, Sarah C. Taggart, Juliet K. Simpson, Arthur R. Kang’ombe, Rebecca Braybrooke, Philip L. Molyneaux, Bernard North, Yakshitha Karkera, Diana J. Leeming, Morten A. Karsdal, Carmel B. Nanthakumar, William A. Fahy, Richard P. Marshall, R. Gisli Jenkins…

    Citation: Respiratory Research 2019 20:148

    Content type: Research

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  33. Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and...

    Authors: Esther P.W.A. Talboom-Kamp, Marije S. Holstege, Niels H. Chavannes and Marise J. Kasteleyn

    Citation: Respiratory Research 2019 20:146

    Content type: Research

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  34. Airway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; howe...

    Authors: Patrizia Pignatti, Dina Visca, Francesca Cherubino, Elisabetta Zampogna, Etienne Lucini, Laura Saderi, Giovanni Sotgiu and Antonio Spanevello

    Citation: Respiratory Research 2019 20:145

    Content type: Research

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  35. The risk and prevalence of chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis (RA) is still obscure. The current study was aimed to systematically review and meta-analyse the risk ratio (RR) ...

    Authors: Yubo Ma, Hui Tong, Xu Zhang, Mengmeng Wang, Jiajia Yang, Meng Wu, Renfang Han, Mengya Chen, Xingxing Hu, Yaping Yuan, Guixia Pan, Yanfeng Zou, Shengqian Xu and Faming Pan

    Citation: Respiratory Research 2019 20:144

    Content type: Review

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  36. Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate t...

    Authors: Ying Duan, Gaowen Liu, Yao Sun, Jiamin Wu, Zichao Xiong, Tianbo Jin and Mingwei Chen

    Citation: Respiratory Research 2019 20:143

    Content type: Research

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  37. There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1...

    Authors: Dave Singh, Anthony D. D’Urzo, James F. Donohue and Edward M. Kerwin

    Citation: Respiratory Research 2019 20:141

    Content type: Review

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  38. Bronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenc...

    Authors: Juergen Hetzel, Ralf Eberhardt, Christoph Petermann, Wolfgang Gesierich, Kaid Darwiche, Lars Hagmeyer, Rainer Muche, Michael Kreuter, Richard Lewis, Ahmed Ehab, Michael Boeckeler and Maik Haentschel

    Citation: Respiratory Research 2019 20:140

    Content type: Research

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  39. Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The s...

    Authors: Kingsley Katleho Mokoena, Crystal Jane Ethan, Yan Yu, Karabo Shale and Feng Liu

    Citation: Respiratory Research 2019 20:139

    Content type: Research

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  40. Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized. Our investigation of 28,727 chest X-rays obtained from annual health...

    Authors: Akira Saito, Yukichika Hakamata, Yukiko Yamada, Mitsuhiro Sunohara, Megumi Tarui, Yoko Murano, Akihisa Mitani, Kimie Tanaka, Takahide Nagase and Shintaro Yanagimoto

    Citation: Respiratory Research 2019 20:138

    Content type: Research

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  41. The severity of Hereditary Hemorrhagic Telangiectasia (HHT) disease is generally related to vascular visceral involvement represented by arteriovenous malformations (AVMs). Pulmonary function tests (PFTs) rema...

    Authors: Carole de Picciotto, Mostafa El Hajjam, Carma Karam, Thierry Chinet and Marcel Bonay

    Citation: Respiratory Research 2019 20:137

    Content type: Letter to the Editor

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  42. The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors fo...

    Authors: Yunjoo Im, Hye Yun Park, Sumin Shin, Sun Hye Shin, Hyun Lee, Joong Hyun Ahn, Insuk Sohn, Jong Ho Cho, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Ho Yun Lee and Jhingook Kim

    Citation: Respiratory Research 2019 20:136

    Content type: Research

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  43. Smoking is a major risk factor for COPD and may impact the efficacy of COPD treatments; however, a large proportion of COPD patients continue to smoke following diagnosis.

    Authors: Donald P. Tashkin, Thomas Goodin, Alyssa Bowling, Barry Price, Ayca Ozol-Godfrey, Sanjay Sharma and Shahin Sanjar

    Citation: Respiratory Research 2019 20:135

    Content type: Research

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  44. Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical cha...

    Authors: F. Bianco, F. Ricci, C. Catozzi, X. Murgia, M. Schlun, A. Bucholski, U. Hetzer, S. Bonelli, M. Lombardini, E. Pasini, M. Nutini, M. Pertile, S. Minocchieri, M. Simonato, B. Rosa, G. Pieraccini…

    Citation: Respiratory Research 2019 20:134

    Content type: Research

    Published on:

  45. Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung...

    Authors: Francesca Polverino, Bao Lu, Joselyn Rojas Quintero, Sara O. Vargas, Avignat S. Patel, Caroline A. Owen, Norma P. Gerard, Craig Gerard and Manuela Cernadas

    Citation: Respiratory Research 2019 20:133

    Content type: Research

    Published on:

  46. Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who are unable to administer medications efficiently with conventional inhalers may benefit from the use of a n...

    Authors: Brian R. Leaker, Dave Singh, Grant C. Nicholson, Blanka Hezelova, Thomas Goodin, Ayca Ozol-Godfrey, Gerald Galluppi and Peter J. Barnes

    Citation: Respiratory Research 2019 20:132

    Content type: Research

    Published on:

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