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  1. Clinically Important Deterioration (CID) is a novel composite measure to assess treatment effect in chronic obstructive pulmonary disease (COPD). We examined the performance and utility of CID in assessing the...

    Authors: Mona Bafadhel, Dave Singh, Christine Jenkins, Stefan Peterson, Thomas Bengtsson, Peter Wessman and Malin Fagerås

    Citation: Respiratory Research 2020 21:17

    Content type: Research

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  2. Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is li...

    Authors: Yifang Liao, Ping Li, Yanxia Wang, Hong Chen, Shangwei Ning and Dongju Su

    Citation: Respiratory Research 2020 21:14

    Content type: Research

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  3. This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC...

    Authors: Sumin Shin, Yong Soo Choi, Jae Jun Jung, Yunjoo Im, Sun Hye Shin, Danbee Kang, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Keunchil Park, Myung-Ju Ahn, Yong Chan Ahn, Genehee Lee, Juhee Cho…

    Citation: Respiratory Research 2020 21:13

    Content type: Research

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  4. Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen. Prognostication in cHP remains challenging, and the relationsh...

    Authors: Julia Wälscher, Benjamin Gross, Julie Morisset, Kerri A. Johannson, Martina Vasakova, Jacques Bruhwyler and Michael Kreuter

    Citation: Respiratory Research 2020 21:12

    Content type: Research

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  5. Several registries of idiopathic pulmonary fibrosis (IPF) have been established to better understand its natural history, though their size and duration of follow-up are limited. Here, we describe the large Eu...

    Authors: Tanja Tran, Martina Šterclová, Nesrin Mogulkoc, Katarzyna Lewandowska, Veronika Müller, Marta Hájková, Mordechai R. Kramer, Dragana Jovanović, Jasna Tekavec-Trkanjec, Michael Studnicka, Natalia Stoeva, Karel Hejduk, Ladislav Dušek, Samy Suissa and Martina Vašáková

    Citation: Respiratory Research 2020 21:11

    Content type: Research

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  6. Although cavities are an important finding in Mycobacterium avium complex pulmonary disease (MAC-PD), there is little information regarding the types of cavities that indicate disease progression. This study was ...

    Authors: Yohei Oshitani, Seigo Kitada, Ryuya Edahiro, Kazuyuki Tsujino, Hiroyuki Kagawa, Kenji Yoshimura, Keisuke Miki, Mari Miki and Hiroshi Kida

    Citation: Respiratory Research 2020 21:10

    Content type: Research

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  7. High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mecha...

    Authors: Cuiping Fu, Shengyu Hao, Zilong Liu, Liang Xie, Xu Wu, Xiaodan Wu and Shanqun Li

    Citation: Respiratory Research 2020 21:9

    Content type: Research

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  8. While porcine seems to be superior to bovine surfactants in terms of respiratory outcomes, it is unclear if a surfactant can improve extra-pulmonary outcomes in preterm neonates with respiratory distress syndr...

    Authors: Silvia Foligno and Daniele De Luca

    Citation: Respiratory Research 2020 21:8

    Content type: Research

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  9. The approvals of nintedanib and pirfenidone changed the treatment paradigm in idiopathic pulmonary fibrosis (IPF), and increased our understanding of the underlying disease mechanisms. Nonetheless, many challe...

    Authors: Claudia Valenzuela, Sebastiano Emanuele Torrisi, Nicolas Kahn, Manuel Quaresma, Susanne Stowasser and Michael Kreuter

    Citation: Respiratory Research 2020 21:7

    Content type: Review

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  10. Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase,...

    Authors: David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli and Paola Rottoli

    Citation: Respiratory Research 2020 21:6

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2020 21:34

  11. Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or the use of asthma medication for ALRTI in patients wit...

    Authors: Rachel Denholm, Esther T. van der Werf and Alastair D. Hay

    Citation: Respiratory Research 2020 21:4

    Content type: Research

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  12. Blood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescrib...

    Authors: Timothy H. Harries, Victoria Rowland, Christopher J. Corrigan, Iain J. Marshall, Lucy McDonnell, Vibhore Prasad, Peter Schofield, David Armstrong and Patrick White

    Citation: Respiratory Research 2020 21:3

    Content type: Research

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  13. Idiopathic pulmonary fibrosis (IPF) is a fatal disease that results in poor quality of life due to progressive respiratory symptoms, anxiety, and depression. Palliative care improves quality of life and surviv...

    Authors: Katherine Janssen, Drew Rosielle, Qi Wang and Hyun Joo Kim

    Citation: Respiratory Research 2020 21:2

    Content type: Research

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  14. To observe the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for pulmonary alveolar proteinosis (PAP).

    Authors: Fen Zhang, Dong Weng, Yiliang Su, Chengsheng Yin, Li Shen, Yuan Zhang, Ying Zhou, Qiuhong Li, Yang Hu and Huiping Li

    Citation: Respiratory Research 2020 21:1

    Content type: Research

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  15. Ventilator-induced diaphragmatic dysfunction is a serious complication associated with higher ICU mortality, prolonged mechanical ventilation, and unsuccessful withdrawal from mechanical ventilation. Although ...

    Authors: Tatsutoshi Shimatani, Nobuaki Shime, Tomohiko Nakamura, Shinichiro Ohshimo, Justin Hotz and Robinder G. Khemani

    Citation: Respiratory Research 2019 20:293

    Content type: Research

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  16. In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell type...

    Authors: Irina Wojahn, Timo H. Lüdtke, Vincent M. Christoffels, Mark-Oliver Trowe and Andreas Kispert

    Citation: Respiratory Research 2019 20:292

    Content type: Research

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  17. Low-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, data on the socioeconomic impact of respiratory dise...

    Authors: Evelyn A. Brakema, Aizhamal Tabyshova, Rianne M. J. J. van der Kleij, Talant Sooronbaev, Christos Lionis, Marilena Anastasaki, Pham Le An, Luan Than Nguyen, Bruce Kirenga, Simon Walusimbi, Maarten J. Postma, Niels H. Chavannes and Job F. M. van Boven

    Citation: Respiratory Research 2019 20:291

    Content type: Research

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  18. Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated...

    Authors: Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard and B. S. Pollard

    Citation: Respiratory Research 2019 20:290

    Content type: Research

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  19. Increased numbers of blood and sputum eosinophils are associated with higher exacerbation frequency and increased asthma severity. In clinical trials, targeting Interleukin-5 has been shown to be a useful ther...

    Authors: H. Ibrahim, R. O’Sullivan, D. Casey, J. Murphy, J. MacSharry, B. J. Plant and D. M. Murphy

    Citation: Respiratory Research 2019 20:289

    Content type: Letter to the Editor

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  20. Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection during childhood may polarise the immune system towards...

    Authors: Brian R. Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson, Barbara Young and Brian O’Connor

    Citation: Respiratory Research 2019 20:288

    Content type: Research

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  21. Acute exacerbation of chronic fibrosing idiopathic interstitial pneumonias (AE-IIPs) is associated with a high mortality rate. In 2016, an international working group proposed a revised diagnostic criteria for...

    Authors: Motoyasu Kato, Tomoko Yamada, Shunichi Kataoka, Yuta Arai, Keita Miura, Yusuke Ochi, Hiroaki Ihara, Ryo Koyama, Shinichi Sasaki and Kazuhisa Takahashi

    Citation: Respiratory Research 2019 20:287

    Content type: Research

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  22. Macrolide is a key drug in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Macrolide-resistant MAC is gaining importance, but there are little data in clinical characteristics and treatme...

    Authors: Youngmok Park, Eun Hye Lee, Inkyung Jung, Goeun Park and Young Ae Kang

    Citation: Respiratory Research 2019 20:286

    Content type: Research

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  23. β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (....

    Authors: Yi-fei Chen, Ge Huang, Yi-min Wang, Ming Cheng, Fang-fang Zhu, Jin-nan Zhong and Ya-dong Gao

    Citation: Respiratory Research 2019 20:285

    Content type: Research

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  24. Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated ...

    Authors: Deirdre F. Gilpin, Katie-Ann McGown, Kevin Gallagher, Jose Bengoechea, Amy Dumigan, Gisli Einarsson, J. Stuart Elborn and Michael M. Tunney

    Citation: Respiratory Research 2019 20:267

    Content type: Research

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  25. Recent advances in the functional analyses of endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs), have provided a new perspective on the crucial roles of RNA in gene regulati...

    Authors: Parameet Kumar, Chaitali Sen, Kathryn Peters, Raymond A. Frizzell and Roopa Biswas

    Citation: Respiratory Research 2019 20:284

    Content type: Research

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  26. There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of...

    Authors: Jin Hwa Song, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung and Jung-Kyu Lee

    Citation: Respiratory Research 2019 20:283

    Content type: Research

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  27. Airway mucus hypersecretion is an important pathophysiological feature in asthma. Mucins are glycoproteins that are mainly responsible for the viscoelastic property of mucus, and MUC5AC is a major mucin glycop...

    Authors: Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Juan Liu, Rong-Fei Sun, Xue-Jiao Qian and Jiang-Bo Liu

    Citation: Respiratory Research 2019 20:282

    Content type: Research

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  28. Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has bee...

    Authors: Wei Liu, Jeffrey A. Meridew, Aja Aravamudhan, Giovanni Ligresti, Daniel J. Tschumperlin and Qi Tan

    Citation: Respiratory Research 2019 20:281

    Content type: Research

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  29. There is currently no method that can predict whether or under what condition hypopnea, even obstructive sleep apnea (OSA), will occur during sleep for individuals based on credible parameters measured under w...

    Authors: Hongyi Lin, Cunting Wang, Han Zhang, Huahui Xiong, Zheng Li, Xiaoqing Huang, Changjin Ji, Junfang Xian and Yaqi Huang

    Citation: Respiratory Research 2019 20:280

    Content type: Research

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  30. Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical paramet...

    Authors: Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee and Ji Ye Jung

    Citation: Respiratory Research 2019 20:279

    Content type: Research

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  31. Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). T...

    Authors: Léo Blervaque, Emilie Passerieux, Pascal Pomiès, Matthias Catteau, Nelly Héraud, Marine Blaquière, François Bughin, Bronia Ayoub, Nicolas Molinari, Jean-Paul Cristol, Antonia Perez-Martin, Jacques Mercier, Maurice Hayot and Fares Gouzi

    Citation: Respiratory Research 2019 20:278

    Content type: Research

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  32. Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and no...

    Authors: Hannah R. Whittaker, Debbie Jarvis, Mohamed R. Sheikh, Steven J. Kiddle and Jennifer K. Quint

    Citation: Respiratory Research 2019 20:277

    Content type: Review

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  33. Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scal...

    Authors: Xinyi Li, Hengye Huang, Huajun Xu, Yue Shi, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan and Shankai Yin

    Citation: Respiratory Research 2019 20:276

    Content type: Research

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  34. Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasi...

    Authors: Hélène Goussault, Hélène Salvator, Emilie Catherinot, Marie-Laure Chabi, Colas Tcherakian, Alexandre Chabrol, Morgane Didier, Elisabeth Rivaud, Alain Fischer, Felipe Suarez, Olivier Hermine, Fanny Lanternier, Olivier Lortholary, Nizar Mahlaoui, Philippe Devillier and Louis-Jean Couderc

    Citation: Respiratory Research 2019 20:275

    Content type: Research

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  35. By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also co...

    Authors: Zhenglong Chen, Ming Zhong, Yuzhou Luo, Linhong Deng, Zhaoyan Hu and Yuanlin Song

    Citation: Respiratory Research 2019 20:274

    Content type: Review

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  36. Poor medication-adherence is common in chronic lung patients, resulting in reduced health-outcomes and increased healthcare-costs. This study aimed to investigate the impact of an acoustic reminder and support...

    Authors: Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Stéphanie Giezendanner, Sabrina Maier, Anne Leuppi-Taegtmeyer, Isabelle Arnet, Kurt E. Hersberger and Jörg D. Leuppi

    Citation: Respiratory Research 2019 20:273

    Content type: Research

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  37. Lower respiratory tract (LRT) microbiome has been reported to associate with pulmonary diseases. Unregulated inflammation is an underlying cause of variable lung diseases. The lung microbiome may play an impor...

    Authors: Kang-jie Li, Zi-long Chen, Yao Huang, Rui Zhang, Xiao-qian Luan, Ting-ting Lei and Ling Chen

    Citation: Respiratory Research 2019 20:272

    Content type: Research

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  38. All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with br...

    Authors: Sooim Sin, Seo Young Yun, Jee Min Kim, Chang Min Park, Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Chang-Hoon Lee

    Citation: Respiratory Research 2019 20:271

    Content type: Research

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  39. Protein tyrosine kinase 2 (PTK2) expression has been reported in various types of human epithelial cancers including lung cancer; however, the role of PTK2 in epidermal growth factor receptor (EGFR)-mutant non...

    Authors: Xuexia Tong, Ryosuke Tanino, Rong Sun, Yukari Tsubata, Tamio Okimoto, Mayumi Takechi and Takeshi Isobe

    Citation: Respiratory Research 2019 20:270

    Content type: Research

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  40. Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is u...

    Authors: Rachel N. Criner, Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, Neil R. MacIntyre, Barry J. Make, Fernando J. Martinez, Wassim W. Labaki, Jeffrey L. Curtis and Mei Lan K. Han

    Citation: Respiratory Research 2019 20:269

    Content type: Letter to the Editor

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  41. Active smoking is the main risk factor for COPD. Here, epigenetic mechanisms may play a role, since cigarette smoking is associated with differential DNA methylation in whole blood. So far, it is unclear wheth...

    Authors: Maaike de Vries, Ivana Nedeljkovic, Diana A. van der Plaat, Alexandra Zhernakova, Lies Lahousse, Guy G. Brusselle, Najaf Amin, Cornelia M. van Duijn, Judith M. Vonk and H. Marike Boezen

    Citation: Respiratory Research 2019 20:268

    Content type: Research

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  42. Our earlier report indicated that active vitamin D3 inhibited epithelial-mesenchymal transition (EMT) in bleomycin (BLM)-induced pulmonary fibrosis. The objective of this study was to further investigate wheth...

    Authors: Se-Ruo Li, Zhu-Xia Tan, Yuan-Hua Chen, Biao Hu, Cheng Zhang, Hua Wang, Hui Zhao and De-Xiang Xu

    Citation: Respiratory Research 2019 20:266

    Content type: Research

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  43. Metagenomic sequencing of respiratory microbial communities for pathogen identification in pneumonia may help overcome the limitations of culture-based methods. We examined the feasibility and clinical validit...

    Authors: Libing Yang, Ghady Haidar, Haris Zia, Rachel Nettles, Shulin Qin, Xiaohong Wang, Faraaz Shah, Sarah F. Rapport, Themoula Charalampous, Barbara Methé, Adam Fitch, Alison Morris, Bryan J. McVerry, Justin O’Grady and Georgios D. Kitsios

    Citation: Respiratory Research 2019 20:265

    Content type: Research

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  44. Impaired mitochondria homeostasis and function are established hallmarks of aging and increasing evidence suggests a link with lung fibrosis. Mitochondria homeostasis may be also affected in alveolar macrophag...

    Authors: Eliza Tsitoura, Eirini Vasarmidi, Eleni Bibaki, Athina Trachalaki, Chara Koutoulaki, George Papastratigakis, Sevasti Papadogiorgaki, George Chalepakis, Nikos Tzanakis and Katerina M. Antoniou

    Citation: Respiratory Research 2019 20:264

    Content type: Research

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  45. Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We...

    Authors: Takuya Aoki, Takeshi Akiba, Jun Nishiyama, Sakurako Tajiri, Naoki Hayama, Genki Takahashi, Jun Tanaka, Masako Sato, Hiroto Takiguchi, Hiromi Tomomatsu, Katsuyoshi Tomomatsu, Takahisa Takihara, Kyoko Niimi, Tsuyoshi Oguma, Mitsutomo Kohno, Ryota Masuda…

    Citation: Respiratory Research 2019 20:263

    Content type: Research

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  46. Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome of primary pulmonary LELC were...

    Authors: Bojiang Chen, Xuping Chen, Ping Zhou, Lan Yang, Jing Ren, Xiaodong Yang and Weimin Li

    Citation: Respiratory Research 2019 20:262

    Content type: Research

    Published on:

  47. Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such,...

    Authors: Kalina R. Atanasova and Leah R. Reznikov

    Citation: Respiratory Research 2019 20:261

    Content type: Review

    Published on:

  48. Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on long-t...

    Authors: Katharina Ruf, Wolfgang Thomas, Maximilian Brunner, Christian P. Speer and Helge Hebestreit

    Citation: Respiratory Research 2019 20:260

    Content type: Research

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  49. Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to...

    Authors: Rebecca L. Vanders, Alan Hsu, Peter G. Gibson, Vanessa E. Murphy and Peter A. B. Wark

    Citation: Respiratory Research 2019 20:259

    Content type: Research

    Published on:

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