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  1. Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally sma...

    Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Ellen Caroline Toledo do Nascimento, Jôse Mara de Brito, Leila Antonangelo, Caroline Silvério Faria, Jhonatas Sirino Monteiro, João Carlos Setubal, João Renato Rebello Pinho, Roberta Verciano Pereira, Marilia Seelaender, Gabriela Salim de Castro, Joanna D. C. C. Lima, Renata Aparecida de Almeida Monteiro, Amaro Nunes Duarte-Neto, Paulo Hilário Nascimento Saldiva…
    Citation: Respiratory Research 2023 24:281
  2. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal disease with limited therapeutic options. The infiltration of monocytes and fibroblasts into the injured lungs is implicated in IPF. Enolase-1 (ENO1) is a...

    Authors: Wei-Ching Huang, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Mao-Lin Chen, Tung-Yueh Chuang, Xiu-Li Yang, Yu-Yau Chou, Chih-Hsin Liu, Nai-Yu Chen, Chun-Jen Chen and Ta-Tung Yuan
    Citation: Respiratory Research 2023 24:280
  3. Several risk factors for Coronavirus-2019 (COVID-19) disease have been highlighted in clinical evidence. Among the various risk factors are advanced age, metabolic illness such as diabetes, heart disease, and ...

    Authors: Antonio Vitiello, Michela Sabbatucci, Andrea Silenzi, Annalisa Capuano, Francesco Rossi, Andrea Zovi, Francesco Blasi and Giovanni Rezza
    Citation: Respiratory Research 2023 24:278
  4. Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid peroxidation. The molecular mechanisms underlying ferroptosis regulation in non-small cell lung cancer (NSCLC) are poo...

    Authors: Guangyao Shan, Guoshu Bi, Guangyin Zhao, Jiaqi Liang, Yunyi Bian, Huan Zhang, Xing Jin, Zhengyang Hu, Guangyu Yao, Hong Fan and Cheng Zhan
    Citation: Respiratory Research 2023 24:277
  5. Lung cancer represents a significant public health issue in China, given its high incidence and mortality rates. Circular RNAs (circRNAs) have been recently proposed to participate in the development and progr...

    Authors: Jie Zhou, Peiwei Li, Xiaogang Zhao, Yuanhao Zhao, Junwen Luo, Yupeng Deng, Ning Jiang, Zhaohua Xiao, Wenhao Zhang, Yongjia Zhou, Jiangfeng Zhao, Peichao Li, Yuliang Li and Zhongxian Tian
    Citation: Respiratory Research 2023 24:276
  6. Objective cough frequency has been reported in several respiratory conditions but the amount that healthy individuals cough daily is unclear. Seventy-nine healthy volunteers (38 males, median [IQR] age 41y [IQ...

    Authors: Kimberley J. Holt and Jaclyn A. Smith
    Citation: Respiratory Research 2023 24:275
  7. Balloon pulmonary angioplasty (BPA) has beneficial effects on pulmonary hemodynamics, exercise capacity, and quality of life (QOL) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Recent...

    Authors: Kazutoshi Hirose, Shun Minatsuki, Akihito Saito, Hiroki Yagi, Norifumi Takeda, Masaru Hatano and Issei Komuro
    Citation: Respiratory Research 2023 24:274
  8. Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) genera...

    Authors: Valentine Mismetti, Xavier Delavenne, David Montani, Souad Bezzeghoud, Olivier Delezay, Sophie Hodin, David Launay, Sylvain Marchand-Adam, Hilario Nunes, Edouard Ollier, Martine Reynaud-Gaubert, Jean Pastre, Julie Traclet, Sébastien Quetant, Sabrina Zeghmar, Laurent Bertoletti…
    Citation: Respiratory Research 2023 24:273
  9. SARS-CoV-2, the agent responsible for the COVID-19 pandemic, enters cells through viral spike glycoprotein binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). Given the lack of effective ...

    Authors: Niayesh Razi, Weizhong Li, Maxinne A. Ignacio, Jeffrey M. Loube, Eva L. Agostino, Xiaoping Zhu, Margaret A. Scull and Jeffrey J. DeStefano
    Citation: Respiratory Research 2023 24:272
  10. Interstitial lung disease (ILD) may be difficult to distinguish from other respiratory diseases due to overlapping clinical presentation. Recognition of ILD is often late, causing delay which has been associat...

    Authors: Iris G. van der Sar, Marlies S. Wijsenbeek, Gert-Jan Braunstahl, Jason O. Loekabino, Anne-Marie C. Dingemans, Johannes C. C. M. In ‘t Veen and Catharina C. Moor
    Citation: Respiratory Research 2023 24:271
  11. Right heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently of the underlying disease. However, the process of RHF development and progression is not fu...

    Authors: Xiaohui Zeng, Ruiyue Zhao, Zhixiong Wu, Zhuoji Ma, Chunxian Cen, Shanshan Gao, Wanxian Hong, Yanrong Yao, Kexin Wen, Shangwei Ding, Jian Wang, Wenju Lu, Xinlu Wang and Tao Wang
    Citation: Respiratory Research 2023 24:270
  12. Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq, we found that asthmatic lungs display lower levels of Isthmin-1 (ISM1) ...

    Authors: Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y. W. Lam, Wupeng Liao, Yuansheng Yang, W. S. Fred Wong and Ruowen Ge
    Citation: Respiratory Research 2023 24:269
  13. Forced vital capacity (FVC) reflects respiratory health, but the long-term trend and heterogeneity in FVC of Chinese students were understudied.

    Authors: Siying Zhang, Lihong Wu, Yumei Zhong, Meirou Shao, Zhiyi Wei, Wenfeng Dong, Aiping Zhu, Fang-biao Tao and Xiulong Wu
    Citation: Respiratory Research 2023 24:268
  14. Airway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies described a chemosensory cell population, which includes tuft cells, by...

    Authors: Monika I. Hollenhorst, Thomas Husnik, Malin Zylka, Nele Duda, Veit Flockerzi, Thomas Tschernig, Stephan Maxeiner and Gabriela Krasteva-Christ
    Citation: Respiratory Research 2023 24:267
  15. Authors: Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E Lascano, Xiao Qiang, Jesse R West, L Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi and Mark Brantly
    Citation: Respiratory Research 2023 24:266

    The original article was published in Respiratory Research 2022 23:232

  16. Quantitative interstitial abnormalities (QIA) are an automated computed tomography (CT) finding of early parenchymal lung disease, associated with worse lung function, reduced exercise capacity, increased resp...

    Authors: Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L. Curtis, Jennifer M. Wang, Rubén San José Estépar, Ivan O. Rosas, Jared R. Mayers, Brian D. Hobbs, Craig P. Hersh, Samuel Y. Ash, MeiLan K. Han, Russell P. Bowler, Kathleen A. Stringer, George R. Washko and Wassim W. Labaki
    Citation: Respiratory Research 2023 24:265
  17. The prevalence and clinical correlates of antibiotic resistance genes (ARGs) in bronchiectasis are not entirely clear. We aimed to profile the ARGs in sputum from adults with bronchiectasis, and explore the as...

    Authors: Xin-zhu Yi, Jun-hao Yang, Yan Huang, Xiao-rong Han, Hui-min Li, Lai-jian Cen, Zhen-hong Lin, Cui-xia Pan, Zhang Wang and Wei-jie Guan
    Citation: Respiratory Research 2023 24:264
  18. Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by abnormal contraction and remodeling of the pulmonary arterioles, manifested ...

    Authors: Cheng Zeng, Jing Liu, Xialei Zheng, Xinqun Hu and Yuhu He
    Citation: Respiratory Research 2023 24:263
  19. The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocor...

    Authors: Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock and Eva Verjans
    Citation: Respiratory Research 2023 24:262
  20. Due to the relatively short existence of alternative tobacco products, gaps exist in our current understanding of their long-term respiratory health effects. We therefore undertook the first-ever side-by-side ...

    Authors: Tariq A. Bhat, Suresh G. Kalathil, Noel Leigh, Alan Hutson, Maciej L. Goniewicz and Yasmin M. Thanavala
    Citation: Respiratory Research 2023 24:261
  21. Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by neutrophilic airway inflammation. Classically activated (or M1) macrophages ...

    Authors: Chenli Chang, Gongqi Chen, Wenliang Wu, Dian Chen, Shengchong Chen, Jiali Gao, Yuchen Feng and Guohua Zhen
    Citation: Respiratory Research 2023 24:260
  22. The diaphragm function assessed by ultrasound has been well-studied in COPD, asthma, and intensive care. However, there are only a few studies on diffuse interstitial lung disease, while dyspnea and quality of...

    Authors: Jules Milesi, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon and Benjamin Coiffard
    Citation: Respiratory Research 2023 24:259
  23. Mechanical thrombectomy has been shown to reduce thrombus burden and pulmonary artery pressure (PAP) and to improve right ventricular (RV) function in patients with high-risk or intermediate-high-risk pulmonar...

    Authors: Lucas Lauder, Patricia Pérez Navarro, Felix Götzinger, Sebastian Ewen, Hussam Al Ghorani, Bernhard Haring, Philipp M. Lepper, Saarraaken Kulenthiran, Michael Böhm, Andreas Link, Bruno Scheller and Felix Mahfoud
    Citation: Respiratory Research 2023 24:257
  24. Neutrophilic airway inflammation is a challenge in asthma management and is associated with poor patient prognosis. Mucin 1 (MUC1), which contains a cytoplasmic tail (MUC1-CT), has been found to mediate glucoc...

    Authors: Lu Liu, Ling Zhou, Lingling Wang, Zhenyu Mao, Pengdou Zheng, Fengqin Zhang, Huojun Zhang and Huiguo Liu
    Citation: Respiratory Research 2023 24:255
  25. Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised by PET/CT imaging. We evaluated whether the measurement of FAP...

    Authors: Philomène Lavis, Julien Pingitore, Gilles Doumont, Ani Garabet, Gaetan Van Simaeys, Simon Lacroix, Nicolas Passon, Christophe Van Heymbeek, Coraline De Maeseneire, Justine Allard, Amandine Collin, François Huaux, Christine Decaestecker, Isabelle Salmon, Serge Goldman, Alessandra Kupper Cardozo…
    Citation: Respiratory Research 2023 24:254
  26. CD147 is an important glycoprotein that participates in the progression of diverse cancers. This study aims to explore the specific function of CD147 in lung adenocarcinoma (LUAD) and to reveal related downstr...

    Authors: Ning Zhang, Zhouzhong Liu, Xuwang Lai, Shubin Liu and Yuli Wang
    Citation: Respiratory Research 2023 24:253
  27. Emerging evidence indicates that circular RNAs (circRNAs) play vital roles in tumor progression, including lung adenocarcinomas (LUAD). However, the mechanisms by which circRNAs promote the progression of LUAD...

    Authors: Haoran Li, Haifa Guo, Qi Huang, Shaodong Wang, Xiao Li and Mantang Qiu
    Citation: Respiratory Research 2023 24:252
  28. Interstitial lung diseases (ILDs) are complex and heterogeneous diseases. The use of traditional diagnostic classification in ILD can lead to suboptimal management, which is worsened by not considering the mol...

    Authors: Francesco Amati, Paolo Spagnolo, Christopher J. Ryerson, Justin M. Oldham, Andrea Gramegna, Anna Stainer, Marco Mantero, Nicola Sverzellati, Donato Lacedonia, Luca Richeldi, Francesco Blasi and Stefano Aliberti
    Citation: Respiratory Research 2023 24:251
  29. Deep inspiration (DI) has been shown to induce bronchodilation and bronchoprotection in bronchochallenged healthy subjects, but not in asthmatics. Strain-induced relaxation of airway smooth muscle (ASM) is con...

    Authors: Yuto Yasuda, Lu Wang, Pasquale Chitano and Chun Y. Seow
    Citation: Respiratory Research 2023 24:250
  30. Platelet count (PLT) is associated positively with lung cancer risk but has a more complex association with body mass index (BMI), positive only in women (mainly never smokers) and inverse in men (mainly ever ...

    Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou and Elio Riboli
    Citation: Respiratory Research 2023 24:249
  31. Microbiome dysbiosis can have long-lasting effects on our health and induce the development of various diseases. Bronchopulmonary dysplasia (BPD) is a multifactorial disease with pre- and postnatal origins inc...

    Authors: Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Kublik, Michael Schloter and Harald Ehrhardt
    Citation: Respiratory Research 2023 24:248
  32. The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reper...

    Authors: Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu and Shih-En Tang
    Citation: Respiratory Research 2023 24:247
  33. Although COVID-19 vaccines and their booster regimens protect against symptomatic infections and severe outcomes, there is limited evidence about their protection against asymptomatic and symptomatic infection...

    Authors: Ting Zeng, Yaoqin Lu, Yanji Zhao, Zihao Guo, Shengzhi Sun, Zhidong Teng, Maozai Tian, Jun Wang, Shulin Li, Xucheng Fan, Weiming Wang, Yongli Cai, Gengze Liao, Xiao Liang, Daihai He, Kai Wang…
    Citation: Respiratory Research 2023 24:246
  34. Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality...

    Authors: Aravind A. Menon, Minyi Lee, Xu Ke, Rachel K. Putman, Takuya Hino, Jonathan A. Rose, Fenghai Duan, Samuel Y. Ash, Michael H. Cho, George T. O’Connor, Josée Dupuis, Hiroto Hatabu, Marc E. Lenburg, Ehab S. Billatos and Gary M. Hunninghake
    Citation: Respiratory Research 2023 24:245
  35. This study, in patients with symptomatic chronic obstructive pulmonary disease (COPD), explored switching therapy from non-extrafine high-dose inhaled corticosteroid/long-acting β2-agonist (ICS/LABA; fluticasone ...

    Authors: Gwen S. Skloot, Alessandro Guasconi, Benjamin R. Lavon, George Georges, Wilfried De Backer, Dmitry Galkin, Mauro Cortellini, Ilaria Panni and Jason H. T. Bates
    Citation: Respiratory Research 2023 24:244
  36. Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by airflow-limiting inflammation and mucus production. Acute exacerbations are a major cause of COPD-related morbidity and mortality...

    Authors: Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants and Silvia Rossi Paccani
    Citation: Respiratory Research 2023 24:243
  37. The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides mechanical support, stability and elastic recoil for different pulmonary cells including the lung fibroblasts. The ECM plays...

    Authors: Sakshi Phogat, Fama Thiam, Safiya Al Yazeedi, Filsan Ahmed Abokor and Emmanuel Twumasi Osei
    Citation: Respiratory Research 2023 24:242
  38. Computed tomography (CT) imaging and artificial intelligence (AI)-based analyses have aided in the diagnosis and prediction of the severity of COVID-19. However, the potential of AI-based CT quantification of ...

    Authors: Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda…
    Citation: Respiratory Research 2023 24:241
  39. Idiopathic pulmonary fibrosis (IPF) has an unknown aetiology and limited treatment options. A recent meta-analysis identified three novel causal variants in the TERT, SPDL1, and KIF15 genes. This observational st...

    Authors: Maria Hollmén, Atte Laaka, Juulia J. Partanen, Jukka Koskela, Eva Sutinen, Riitta Kaarteenaho, Mari Ainola and Marjukka Myllärniemi
    Citation: Respiratory Research 2023 24:240
  40. Use of combinations of long-acting β2 agonists/long-acting muscarinic antagonists (LABA/LAMA) in patients with chronic obstructive pulmonary disease (COPD) is increasing. Nevertheless, existing evidence on cardio...

    Authors: Chun-Yu Chen, Sheng-Wei Pan, Chia-Chen Hsu, Jason J. Liu, Hiraku Kumamaru and Yaa-Hui Dong
    Citation: Respiratory Research 2023 24:239
  41. Rhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with injury-repair responses in the airways that collectively contribute to airwa...

    Authors: Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr. and Cynthia J. Koziol-White
    Citation: Respiratory Research 2023 24:238
  42. Airway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to chronic airway disease (CAD) can cause ABSC dysfunction, it remains uncle...

    Authors: Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu and Shi-Yue Li
    Citation: Respiratory Research 2023 24:237
  43. The role of the immune system in the pathobiology of Idiopathic Pulmonary Fibrosis (IPF) is controversial.

    Authors: Tamara Cruz, Núria Mendoza, Sandra Casas-Recasens, Guillaume Noell, Fernanda Hernandez-Gonzalez, Alejandro Frino-Garcia, Xavi Alsina-Restoy, María Molina, Mauricio Rojas, Alvar Agustí, Jacobo Sellares and Rosa Faner
    Citation: Respiratory Research 2023 24:236
  44. The ORBE II study aimed to describe the characteristics and clinical outcomes of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting in Spain.

    Authors: Alicia Padilla-Galo, Isabel Moya Carmona, Pilar Ausín, Luis Carazo Fernández, Ismael García-Moguel, José Luis Velasco-Garrido, Rubén Andújar-Espinosa, Francisco Casas-Maldonado, Eva Martínez-Moragón, Carlos Martínez Rivera, Elisabet Vera Solsona, Fernando Sánchez-Toril López, Andrea Trisán Alonso, Marina Blanco Aparicio, Marcela Valverde-Monge, Borja Valencia Azcona…
    Citation: Respiratory Research 2023 24:235
  45. As the prevalence of OSA increases in older patients, the proportion of elderly patients treated with CPAP is expected to become even higher. We studied CPAP-adherence in a real-life cohort involving a large p...

    Authors: Arnaud Prigent, Clément Blanloeil, Anne-Laure Serandour, Franck Barlet, Frédéric Gagnadoux and Dany Jaffuel
    Citation: Respiratory Research 2023 24:234
  46. Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) have been highly studied with their critical roles as carriers of therapeutic targets such as microRNAs (miRNAs) in the treatment of ...

    Authors: Mengzhi Wan, Caiju Lu, Yu Liu, Feng Luo, Jing Zhou and Fei Xu
    Citation: Respiratory Research 2023 24:233
  47. The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients w...

    Authors: Christian Rønn, Peter Kamstrup, Josefin Eklöf, Louise Lindhardt Toennesen, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Ram Benny Dessau, Jon Torgny Wilcke, Pradeesh Sivapalan, Charlotte Suppli Ulrik and Jens-Ulrik Stæhr Jensen
    Citation: Respiratory Research 2023 24:232
  48. Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timin...

    Authors: Peter Rosenberger, Lisa Korell, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Linyan Tang, Andreas Körner, Peter Martus and Michael Koeppen
    Citation: Respiratory Research 2023 24:230

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