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Respiratory Research

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  1. Content type: Research

    Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for cardiovascular (CV) disease, one of the most frequent causes of death in COPD patients. The goal of the present study was to evalu...

    Authors: Jorge Zagaceta, Gorka Bastarrika, Javier J. Zulueta, Inmaculada Colina, Ana B. Alcaide, Arantza Campo, Miguel Divo, Ciro Casanova, José M. Marin, Victor M. Pinto-Plata, Bartolome R. Celli and Juan P. de-Torres

    Citation: Respiratory Research 2017 18:175

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  2. Content type: Research

    Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors N...

    Authors: Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma and Hong Ye

    Citation: Respiratory Research 2017 18:174

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  3. Content type: Research

    Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway...

    Authors: S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby and Steven M. Rowe

    Citation: Respiratory Research 2017 18:173

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  4. Content type: Research

    Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR...

    Authors: Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara and Yasuhiko Nishioka

    Citation: Respiratory Research 2017 18:172

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  5. Content type: Research

    Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients w...

    Authors: Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier and Robert Bals

    Citation: Respiratory Research 2017 18:171

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  6. Content type: Research

    Regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in idiopathic pulmonary fibrosis (IPF) is unclear. This study was designed to explore the role of T...

    Authors: Ziliang Hou, Qiao Ye, Meihua Qiu, Yu Hao, Junyan Han and Hui Zeng

    Citation: Respiratory Research 2017 18:170

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  7. Content type: Research

    Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at dete...

    Authors: Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal and Manal S. Fawzy

    Citation: Respiratory Research 2017 18:169

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  8. Content type: Review

    Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have demonstrated that deficiency of ITSN-1s is a cruci...

    Authors: Niranjan Jeganathan, Dan Predescu and Sanda Predescu

    Citation: Respiratory Research 2017 18:168

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  9. Content type: Review

    Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the va...

    Authors: Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei and Judit E. Pongracz

    Citation: Respiratory Research 2017 18:167

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  10. Content type: Research

    Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical i...

    Authors: Xin Lv, Tao Wen, Jiong Song, Dong Xie, Liang Wu, Xuemei Jiang, Ping Jiang and Zongmei Wen

    Citation: Respiratory Research 2017 18:165

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  11. Content type: Research

    Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS)...

    Authors: Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou and Jordan P. Metcalf

    Citation: Respiratory Research 2017 18:166

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  12. Content type: Research

    Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...

    Authors: Solveig Tangedal, Marianne Aanerud, Rune Grønseth, Christine Drengenes, Harald G. Wiker, Per S. Bakke and Tomas M. Eagan

    Citation: Respiratory Research 2017 18:164

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  13. Content type: Research

    Tracheal obstruction resulting from expiratory tracheal deformation has been associated with respiratory symptoms and severe airway exacerbations. In chronic obstructive pulmonary disease (COPD), acute exacerb...

    Authors: Paul Leong, Anne Tran, Jhanavi Rangaswamy, Laurence E. Ruane, Michael W. Fernando, Martin I. MacDonald, Kenneth K. Lau and Philip G. Bardin

    Citation: Respiratory Research 2017 18:163

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  14. Content type: Research

    COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors.

    Authors: Andreas Horner, Joan B. Soriano, Milo A. Puhan, Michael Studnicka, Bernhard Kaiser, Lowie E. G. W. Vanfleteren, Louisa Gnatiuc, Peter Burney, Marc Miravitlles, Francisco García-Rio, Julio Ancochea, Ana M. Menezes, Rogelio Perez-Padilla, Maria Montes de Oca, Carlos A. Torres-Duque, Andres Caballero…

    Citation: Respiratory Research 2017 18:162

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  15. Content type: Research

    Autoimmune serologies are often obtained in the initial evaluation of uncharacterized interstitial lung disease (ILD). Whether this practice is helpful in delineating connective-tissue disease related ILD (CTD...

    Authors: Mohammad Alsumrain, Federica De Giacomi, Shireen Mirza and Teng Moua

    Citation: Respiratory Research 2017 18:161

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  16. Content type: Research

    Cigarette smoking has been associated with the risk of idiopathic pulmonary fibrosis (IPF). Certain comorbidities have been associated with reduced survival although some studies have indicated that current sm...

    Authors: Miia Kärkkäinen, Hannu-Pekka Kettunen, Hanna Nurmi, Tuomas Selander, Minna Purokivi and Riitta Kaarteenaho

    Citation: Respiratory Research 2017 18:160

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  17. Content type: Research

    Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction.

    Authors: Emmanuel Briend, G. John Ferguson, Michiko Mori, Gautam Damera, Katherine Stephenson, Natasha A. Karp, Sanjay Sethi, Christine K. Ward, Matthew A. Sleeman, Jonas S. Erjefält and Donna K. Finch

    Citation: Respiratory Research 2017 18:159

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  18. Content type: Erratum

    Authors: Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Citation: Respiratory Research 2017 18:158

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    The original article was published in Respiratory Research 2017 18:8

  19. Content type: Research

    Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover stu...

    Authors: Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose and Ubaldo Martin

    Citation: Respiratory Research 2017 18:157

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  20. Content type: Review

    Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the ...

    Authors: Brittany Salter, Cara Pray, Katherine Radford, James G. Martin and Parameswaran Nair

    Citation: Respiratory Research 2017 18:156

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  21. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that th...

    Authors: Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu and Zhijun Jie

    Citation: Respiratory Research 2017 18:155

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  22. Content type: Review

    Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over...

    Authors: Seyed M. Moosavi, Pavan Prabhala and Alaina J. Ammit

    Citation: Respiratory Research 2017 18:154

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  23. Content type: Research

    Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice...

    Authors: Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf and Koustav Ganguly

    Citation: Respiratory Research 2017 18:152

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  24. Content type: Research

    Interleukin-1 receptor 1 (IL-1R1) inhibition is a potential strategy for treating patients with chronic obstructive pulmonary disease (COPD). MEDI8968, a fully human monoclonal antibody, binds selectively to I...

    Authors: Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold and René van der Merwe

    Citation: Respiratory Research 2017 18:153

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  25. Content type: Review

    The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after l...

    Authors: Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson and Lars C. Huber

    Citation: Respiratory Research 2017 18:151

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