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  1. Content type: Research

    ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

    Authors: Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand and Cornelius J. Busch

    Citation: Respiratory Research 2018 19:29

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  2. Content type: Research

    Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

    Authors: Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning and Jie Cao

    Citation: Respiratory Research 2018 19:28

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  3. Content type: Research

    Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

    Authors: Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng and Guodong Hu

    Citation: Respiratory Research 2018 19:27

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  4. Content type: Research

    A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...

    Authors: Kate M. Johnson, Stirling Bryan, Shahzad Ghanbarian, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:26

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  5. Content type: Research

    Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

    Authors: Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey and Toby M. Maher

    Citation: Respiratory Research 2018 19:25

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  6. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...

    Authors: Javier Milara, Gracia Hernandez, Beatriz Ballester, Anselm Morell, Inés Roger, P. Montero, Juan Escrivá, José M. Lloris, Maria Molina-Molina, Esteban Morcillo and Julio Cortijo

    Citation: Respiratory Research 2018 19:24

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  7. Content type: Research

    Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

    Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps and Joanna Floros

    Citation: Respiratory Research 2018 19:23

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  8. Content type: Research

    Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

    Authors: Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya and Koichi Omori

    Citation: Respiratory Research 2018 19:22

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  9. Content type: Research

    Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unk...

    Authors: Ashraf Fawzy, Nirupama Putcha, Laura M. Paulin, Carrie P. Aaron, Wassim W. Labaki, MeiLan K. Han, Robert A. Wise, Richard E. Kanner, Russell P. Bowler, R. Graham Barr and Nadia N. Hansel

    Citation: Respiratory Research 2018 19:20

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  10. Content type: Research

    Abnormal apoptosis of lung endothelial cells has been observed in emphysematous lung tissue and has been suggested to be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease...

    Authors: Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen and Ping Chen

    Citation: Respiratory Research 2018 19:21

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  11. Content type: Research

    Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patie...

    Authors: Peter R. Bremner, Ruby Birk, Noushin Brealey, Afisi S. Ismaila, Chang-Qing Zhu and David A. Lipson

    Citation: Respiratory Research 2018 19:19

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  12. Content type: Review

    Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential ...

    Authors: Julien Dimastromatteo, Eric J. Charles and Victor E. Laubach

    Citation: Respiratory Research 2018 19:17

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  13. Content type: Research

    Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...

    Authors: Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi and Lena Uller

    Citation: Respiratory Research 2018 19:16

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  14. Content type: Research

    We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of long-acting bronchodilators on exercise capacity in COPD patients.

    Authors: Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi and Stefano Centanni

    Citation: Respiratory Research 2018 19:18

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    The Correction to this article has been published in Respiratory Research 2018 19:70

  15. Content type: Research

    Accumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution. Their small size facilitates dispersal and subsequent exposur...

    Authors: Angela M. Fonceca, Graeme R. Zosky, Elizabeth M. Bozanich, Erika N. Sutanto, Anthony Kicic, Paul S. McNamara, Darryl A. Knight, Peter D. Sly, Debra J. Turner and Stephen M. Stick

    Citation: Respiratory Research 2018 19:15

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  16. Content type: Research

    Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

    Authors: Mark D. Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E. Lipson, Todd W. Seeley and Peter E. Huber

    Citation: Respiratory Research 2018 19:14

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  17. Content type: Research

    Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael Silva O.

    Citation: Respiratory Research 2018 19:13

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    The Correction to this article has been published in Respiratory Research 2018 19:77

  18. Content type: Review

    Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guideline...

    Authors: Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi and Claus F. Vogelmeier

    Citation: Respiratory Research 2018 19:11

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  19. Content type: Research

    Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increase...

    Authors: Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson and Christer Janson

    Citation: Respiratory Research 2018 19:12

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  20. Content type: Review

    Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in han...

    Authors: Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington and Richard Dekhuijzen

    Citation: Respiratory Research 2018 19:10

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  21. Content type: Letter to the Editor

    Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its tr...

    Authors: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates and Ann B. Millar

    Citation: Respiratory Research 2018 19:9

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  22. Content type: Commentary

    While the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) at rest is known to be associated with prognosis in pulmonary arterial hypertension (PAH), it is unclear if the NT-proBNP response to exercis...

    Authors: J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair and T. M. Berghaus

    Citation: Respiratory Research 2018 19:8

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  23. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. Patients present loss of lung function, dyspnea and dry cough. Diagnosis requires compatible radiologic imaging and, in undeter...

    Authors: Barbara Rindlisbacher, Cornelia Schmid, Thomas Geiser, Cédric Bovet and Manuela Funke-Chambour

    Citation: Respiratory Research 2018 19:7

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  24. Content type: Research

    There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our obje...

    Authors: Theresa A. Laguna, Cynthia B. Williams, Myra G. Nunez, Cole Welchlin-Bradford, Catherine E. Moen, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2018 19:6

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  25. Content type: Research

    Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress t...

    Authors: Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song and Jue Pan

    Citation: Respiratory Research 2018 19:5

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  26. Content type: Research

    Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a...

    Authors: Yinna Wang, Alyssa C. Rezey, Ruping Wang and Dale D. Tang

    Citation: Respiratory Research 2018 19:4

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  27. Content type: Research

    Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from p...

    Authors: E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage and Zissis C. Chroneos

    Citation: Respiratory Research 2018 19:3

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  28. Content type: Research

    Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed t...

    Authors: Manish Bodas, Steven Mazur, Taehong Min and Neeraj Vij

    Citation: Respiratory Research 2018 19:2

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  29. Content type: Letter to the Editor

    Hemokinin-1 (HK-1) is a novel neuropeptide produced by human bronchial cells and macrophages and causes contraction of human bronchi ex vivo. It is also generated by antigen/IgE-activated murine mast cells (MC...

    Authors: Wichayapha Manorak, Chizobam Idahosa, Kshitij Gupta, Saptarshi Roy, Reynold Panettieri Jr and Hydar Ali

    Citation: Respiratory Research 2018 19:1

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  30. Content type: Research

    Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps ...

    Authors: Katerina D. Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V. Koutsopoulos, Eleni D. Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M. Siafakas, Nikolaos Tzanakis, Athol U. Wells and Katerina M. Antoniou

    Citation: Respiratory Research 2017 18:218

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  31. Content type: Research

    Exposure to ambient ozone (O3) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O3 to trigger asthma exacerbations are sti...

    Authors: Aihua Bao, Hong Yang, Jie Ji, Yuqin Chen, Wuping Bao, Feng Li, Min Zhang, Xin Zhou, Qiang Li and Suqin Ben

    Citation: Respiratory Research 2017 18:216

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  32. Content type: Research

    SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However,...

    Authors: Zhilong Jiang, Zhihong Chen, Liyang Li, Wenjun Zhou and Lei Zhu

    Citation: Respiratory Research 2017 18:217

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  33. Content type: Research

    In vitro systems of primary cystic fibrosis (CF) airway epithelial cells are an important tool to study molecular and functional features of the native respiratory epithelium. However, undifferentiated CF airw...

    Authors: Aline Schögler, Fabian Blank, Melanie Brügger, Seraina Beyeler, Stefan A. Tschanz, Nicolas Regamey, Carmen Casaulta, Thomas Geiser and Marco P. Alves

    Citation: Respiratory Research 2017 18:215

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  34. Content type: Research

    Agriculture organic dust exposures induce lung disease with lymphoid aggregates comprised of both T and B cells. The precise role of B cells in mediating lung inflammation is unknown, yet might be relevant giv...

    Authors: Jill A. Poole, Ted R. Mikuls, Michael J. Duryee, Kristi J. Warren, Todd A. Wyatt, Amy J. Nelson, Debra J. Romberger, William W. West and Geoffrey M. Thiele

    Citation: Respiratory Research 2017 18:214

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  35. Content type: Research

    Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflam...

    Authors: Matthew L. Stone, Yunge Zhao, J. Robert Smith, Mark L. Weiss, Irving L. Kron, Victor E. Laubach and Ashish K. Sharma

    Citation: Respiratory Research 2017 18:212

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  36. Content type: Research

    Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigat...

    Authors: Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma…

    Citation: Respiratory Research 2017 18:213

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  37. Content type: Review

    The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data fro...

    Authors: Andrea Gramegna, Francesco Amati, Leonardo Terranova, Giovanni Sotgiu, Paolo Tarsia, Daniela Miglietta, Maria Adelaide Calderazzo, Stefano Aliberti and Francesco Blasi

    Citation: Respiratory Research 2017 18:211

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  38. Content type: Research

    Although the majority of solitary fibrous tumors of the pleura (SFTP) follow a benign course, 10–25% of patients suffer from recurrence or metastatic disease. Several scoring models have been proposed to predi...

    Authors: Matthias Diebold, Alex Soltermann, Selma Hottinger, Sarah R. Haile, Lukas Bubendorf, Paul Komminoth, Wolfram Jochum, Rainer Grobholz, Dirk Theegarten, Sabina Berezowska, Kaid Darwiche, Filiz Oezkan, Malcolm Kohler and Daniel P. Franzen

    Citation: Respiratory Research 2017 18:210

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  39. Content type: Research

    Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with large negative intrathoracic pressures, due to strenuous contractions of the inspiratory muscles. IRB is sho...

    Authors: Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis and Theodoros Vassilakopoulos

    Citation: Respiratory Research 2017 18:209

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  40. Content type: Research

    Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Ye...

    Authors: P.-J. Royer, K. Henrio, M. Pain, J. Loy, A. Roux, A. Tissot, P. Lacoste, C. Pison, S. Brouard and A. Magnan

    Citation: Respiratory Research 2017 18:208

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  41. Content type: Research

    Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammatio...

    Authors: Amandine Vargas, Roxane Boivin, Patricia Cano, Yoana Murcia, Isabelle Bazin and Jean-Pierre Lavoie

    Citation: Respiratory Research 2017 18:207

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  42. Content type: Research

    This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airf...

    Authors: Leif Bjermer, Job F. M. van Boven, Madlaina Costa-Scharplatz, Dorothy L. Keininger, Florian S. Gutzwiller, Karin Lisspers, Ronan Mahon, Petter Olsson and Nicolas Roche

    Citation: Respiratory Research 2017 18:206

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  43. Content type: Research

    Obesity is a risk factor for the development of asthma. In patients with obesity the diagnosis of asthma is often based on symptoms, but without objective measurements. Nevertheless, obesity-associated asthma ...

    Authors: Marise J. Kasteleyn, Tobias N. Bonten, Renée de Mutsert, Willemien Thijs, Pieter S. Hiemstra, Saskia le Cessie, Frits R. Rosendaal, Niels H. Chavannes and Christian Taube

    Citation: Respiratory Research 2017 18:205

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  44. Content type: Research

    The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate th...

    Authors: Sang Hoon Lee, Moo Suk Park, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Woo Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal…

    Citation: Respiratory Research 2017 18:204

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  45. Content type: Review

    Current guidelines recommend a single inhaler maintenance and reliever therapy (SMART) regimen for moderate to severe asthma. However, evidence for the inhaled corticosteroid plus fast-onset-acting β2-agonist (IC...

    Authors: Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J. Barnes and Gang Wang

    Citation: Respiratory Research 2017 18:203

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  46. Content type: Review

    Pulmonary arterial hypertension (PAH) is a chronic pulmonary vascular disease characterized by increased pulmonary vascular resistance (PVR) leading to right ventricular (RV) failure. Autonomic nervous system ...

    Authors: Mylène Vaillancourt, Pamela Chia, Shervin Sarji, Jason Nguyen, Nir Hoftman, Gregoire Ruffenach, Mansoureh Eghbali, Aman Mahajan and Soban Umar

    Citation: Respiratory Research 2017 18:201

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  47. Content type: Research

    Long-acting muscarinic antagonists (LAMAs) are recommended for the treatment of chronic obstructive pulmonary disease (COPD). Glycopyrrolate/eFlow® is an investigational drug–device combination of the LAMA gly...

    Authors: James F. Donohue, Thomas Goodin, Robert Tosiello and Alistair Wheeler

    Citation: Respiratory Research 2017 18:202

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  48. Content type: Research

    Clinical audits have reported considerable variability in COPD medical care and frequent inconsistencies with recommendations. The objectives of this study were to identify factors associated with a better adh...

    Authors: Myriam Calle Rubio, José Luis López-Campos, Juan J. Soler-Cataluña, Bernardino Alcázar Navarrete, Joan B. Soriano, José Miguel Rodríguez González-Moro, Manuel E. Fuentes Ferrer and Juan Luis Rodríguez Hermosa

    Citation: Respiratory Research 2017 18:200

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  49. Content type: Research

    Asthma is characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and airway remodeling. While exposure of house dust mites (HDM) is a common cause of asthma, the pathogenesis of the HD...

    Authors: Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu and Zhou Fu

    Citation: Respiratory Research 2017 18:199

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  50. Content type: Review

    According to the current clinical practice guidelines for chronic obstructive pulmonary disease (COPD), the addition of inhaled corticosteroids (ICS) to long-acting β2 agonist therapy is recommended in patients w...

    Authors: Marc Miravitlles, Borja G. Cosío, Aurelio Arnedillo, Myriam Calle, Bernardino Alcázar-Navarrete, Cruz González, Cristóbal Esteban, Juan Antonio Trigueros, José Miguel Rodríguez González-Moro, José Antonio Quintano Jiménez and Adolfo Baloira

    Citation: Respiratory Research 2017 18:198

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