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  1. Allergen-containing subpollen particles (SPP) are released from whole plant pollen upon contact with water or even high humidity. Because of their size SPP can preferentially reach the lower airways where they...

    Authors: Carsten Schleh, Veit J Erpenbeck, Carla Winkler, Hans D Lauenstein, Matthias Nassimi, Armin Braun, Norbert Krug and Jens M Hohlfeld
    Citation: Respiratory Research 2010 11:83
  2. Pulmonary function has been reported in mice using negative pressure-driven forced expiratory manoeuvres (NPFE) and the forced oscillation technique (FOT). However, both techniques have always been studied usi...

    Authors: Karim H Shalaby, Leslie G Gold, Thomas F Schuessler, James G Martin and Annette Robichaud
    Citation: Respiratory Research 2010 11:82
  3. Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been ...

    Authors: Bakytbek Egemnazarov, Ralph T Schermuly, Bhola K Dahal, Garry T Elliott, Niel C Hoglen, Mark W Surber, Norbert Weissmann, Friedrich Grimminger, Werner Seeger and Hossein A Ghofrani
    Citation: Respiratory Research 2010 11:81
  4. We have previously shown that NK (CD56+CD3-) and NKT-like (CD56+CD3+) cells are reduced in both numbers and cytotoxicity in peripheral blood. The aim of the present study was to investigate their numbers and func...

    Authors: Richard A Urbanowicz, Jonathan R Lamb, Ian Todd, Jonathan M Corne and Lucy C Fairclough
    Citation: Respiratory Research 2010 11:76
  5. "Inflammation resolution" has of late become a topical research area. Activation of resolution phase mechanisms, involving select post-transcriptional regulons, transcription factors, 'autacoids', and cell phe...

    Authors: Carl G Persson and Lena Uller
    Citation: Respiratory Research 2010 11:75
  6. Internet-based self-management has shown to improve asthma control and asthma related quality of life, but the improvements were only marginally clinically relevant for the group as a whole. We hypothesized th...

    Authors: Victor van der Meer, Henk F van Stel, Moira J Bakker, Albert C Roldaan, Willem JJ Assendelft, Peter J Sterk, Klaus F Rabe and Jacob K Sont
    Citation: Respiratory Research 2010 11:74
  7. Previous studies indicate that patients with pulmonary arterial hypertension (PAH) carrying a mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene, develop the disease 10 years earlier than non...

    Authors: Barbara Girerd, David Montani, Mélanie Eyries, Azzedine Yaici, Benjamin Sztrymf, Florence Coulet, Olivier Sitbon, Gérald Simonneau, Florent Soubrier and Marc Humbert
    Citation: Respiratory Research 2010 11:73
  8. An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrop...

    Authors: Pankaj K Bhavsar, Bruce D Levy, Mark J Hew, Michael A Pfeffer, Shamsah Kazani, Elliot Israel and Kian Fan Chung
    Citation: Respiratory Research 2010 11:71
  9. Debate exists as to whether welding fume is carcinogenic, but epidemiological evidence suggests that welders are an at risk population for the development of lung cancer. Recently, we found that exposure to we...

    Authors: Patti C Zeidler-Erdely, Michael L Kashon, Shengqiao Li and James M Antonini
    Citation: Respiratory Research 2010 11:70
  10. Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARγ de...

    Authors: Dawn M Simon, Larry W Tsai, Edward P Ingenito, Barry C Starcher and Thomas J Mariani
    Citation: Respiratory Research 2010 11:69
  11. Despite the widespread induction of miR-146a during the innate immune response little is known regarding its biogenesis, function and mechanism. We have therefore examined the role of miR-146a during the inter...

    Authors: Hanna M Larner-Svensson, Andrew E Williams, Eleni Tsitsiou, Mark M Perry, Xiaoying Jiang, Kian F Chung and Mark A Lindsay
    Citation: Respiratory Research 2010 11:68
  12. Nontypeable Haemophilus influenzae (NTHI) may play a role as an infectious trigger in the pathogenesis of chronic obstructive pulmonary disease (COPD). Few data are available regarding the influence of acute and ...

    Authors: Daniel Drömann, Jan Rupp, Kristina Rohmann, Sinia Osbahr, Artur J Ulmer, Sebastian Marwitz, Kristina Röschmann, Mahdi Abdullah, Holger Schultz, Ekkehard Vollmer, Peter Zabel, Klaus Dalhoff and Torsten Goldmann
    Citation: Respiratory Research 2010 11:67
  13. The budesonide/formoterol combination is successfully used for fast relief of asthma symptoms in addition to its use as maintenance therapy. The temporarily increased corticosteroid dose during increasing inha...

    Authors: René Aalbers, Martin Boorsma, Hanneke J van der Woude and René E Jonkers
    Citation: Respiratory Research 2010 11:66
  14. Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K+ channel modulators regulate ENaC activity in normal...

    Authors: Dong-Yun Han, Hong-Guang Nie, Xiu Gu, Ramesh C Nayak, Xue-Feng Su, Jian Fu, Yongchang Chang, Vijay Rao and Hong-Long Ji
    Citation: Respiratory Research 2010 11:65
  15. Elevated circulating levels of several inflammatory biomarkers have been described in selected patient populations with COPD, although less is known about their population-based distribution. The aims of this ...

    Authors: Francisco Garcia-Rio, Marc Miravitlles, Joan B Soriano, Luis Muñoz, Enric Duran-Tauleria, Guadalupe Sánchez, Víctor Sobradillo and Julio Ancochea
    Citation: Respiratory Research 2010 11:63
  16. Previous observations demonstrate that Cftr-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased de novo synthesis, and an increase in pla...

    Authors: Danjun Fang, Richard H West, Mary E Manson, Jennifer Ruddy, Dechen Jiang, Stephen F Previs, Nitin D Sonawane, James D Burgess and Thomas J Kelley
    Citation: Respiratory Research 2010 11:61
  17. Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (C...

    Authors: Simona E Budulac, Dirkje S Postma, Pieter S Hiemstra, Lisette IZ Kunz, Mateusz Siedlinski, Henriette A Smit, Judith M Vonk, Bea Rutgers, Wim Timens and H Marike Boezen
    Citation: Respiratory Research 2010 11:60
  18. Bacterial colonisation in chronic obstructive pulmonary disease (COPD) contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD.

    Authors: Marc Miravitlles, Alicia Marín, Eduard Monsó, Sara Vilà, Cristian de la Roza, Ramona Hervás, Cristina Esquinas, Marian García, Laura Millares, Josep Morera and Antoni Torres
    Citation: Respiratory Research 2010 11:58
  19. Angiotensin converting enzyme (ACE) gene contains a polymorphism, consisting of either the presence (I) or absence (D) of a 287 base pair fragment. Deletion (D) is associated with increased circulating ACE (cA...

    Authors: Gabriel Dimitriou, Despina Papakonstantinou, Eleana F Stavrou, Sotirios Tzifas, Aggeliki Vervenioti, Anny Onufriou, Aglaia Athanassiadou and Stefanos Mantagos
    Citation: Respiratory Research 2010 11:57
  20. Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of mortality worldwide. Long-acting bronchodilators are considered first line therapies for patients with COPD but their effects on mortality ...

    Authors: Agnes Kliber, Larry D Lynd and Don D Sin
    Citation: Respiratory Research 2010 11:56
  21. Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role in this process as regulators of the integrity of the extracellular matrix. Altered proteoglycan...

    Authors: Oskar Hallgren, Kristian Nihlberg, Magnus Dahlbäck, Leif Bjermer, Leif T Eriksson, Jonas S Erjefält, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2010 11:55
  22. It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However, this has not been demonstrated in human allergic airways in vivo. Based on animal in...

    Authors: Lena Uller, Cecilia Ahlström Emanuelsson, Morgan Andersson, Jonas S Erjefält, Lennart Greiff and Carl G Persson
    Citation: Respiratory Research 2010 11:54
  23. Perfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells and surfactant metabolism can be expe...

    Authors: Andreas Wemhöner, Irmgard Hackspiel, Nina Hobi, Andrea Ravasio, Thomas Haller and Mario Rüdiger
    Citation: Respiratory Research 2010 11:52
  24. The dust mite Blomia tropicalis is an important source of aeroallergens in tropical areas. Although a mouse model for B. tropicalis extract (BtE)-induced asthma has been described, no study comparing different mo...

    Authors: Tiana Baqueiro, Momtchilo Russo, Virgínia MG Silva, Thayna Meirelles, Pablo RS Oliveira, Eliane Gomes, Renato Barboza, Ana T Cerqueira-Lima, Camila A Figueiredo, Lain Pontes-de-Carvalho and Neuza M Alcântara-Neves
    Citation: Respiratory Research 2010 11:51
  25. The non-invasive assessment of airway inflammation is potentially advantageous in asthma management. Exhaled carbon monoxide (eCO) measurement is cheap and has been proposed to reflect airway inflammation and ...

    Authors: Jingying Zhang, Xin Yao, Rongbin Yu, Jianling Bai, Yun Sun, Mao Huang, Ian M Adcock and Peter J Barnes
    Citation: Respiratory Research 2010 11:50
  26. Lungs of cystic fibrosis (CF) patients are chronically infected with Pseudomonas aeruginosa. Increased airway constriction has been reported in CF patients but underplaying mechanisms have not been elucidated. Ai...

    Authors: Yong-Zheng Wu, Mohammad Abolhassani, Mario Ollero, Fariel Dif, Naonori Uozumi, Micheline Lagranderie, Takao Shimizu, Michel Chignard and Lhousseine Touqui
    Citation: Respiratory Research 2010 11:49
  27. A major feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, which includes an increased airway smooth muscle (ASM) mass. The mechanisms underlying ASM remodelling in COPD are current...

    Authors: Tonio Pera, Reinoud Gosens, Andries H Lesterhuis, Riham Sami, Marco van der Toorn, Johan Zaagsma and Herman Meurs
    Citation: Respiratory Research 2010 11:48
  28. The exhaled nitric oxide (eNO) signal is a marker of inflammation, and can be partitioned into proximal [J'awNO (nl/s), maximum airway flux] and distal contributions [CANO (ppb), distal airway/alveolar NO concent...

    Authors: James L Puckett, Richard WE Taylor, Szu-Yun Leu, Olga L Guijon, Anna S Aledia, Stanley P Galant and Steven C George
    Citation: Respiratory Research 2010 11:47
  29. Abnormal apoptotic events in chronic obstructive pulmonary disease (COPD) subvert cellular homeostasis and may play a primary role in its pathogenesis. However, studies in human subjects are limited.

    Authors: Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas and Eleni G Tzortzaki
    Citation: Respiratory Research 2010 11:46
  30. Abnormal immune responses are believed to be highly relevant in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dendritic cells provide a critical checkpoint for immunity by their capacity to...

    Authors: Robert Vassallo, Paula R Walters, Jeffrey Lamont, Theodore J Kottom, Eunhee S Yi and Andrew H Limper
    Citation: Respiratory Research 2010 11:45
  31. Previous studies of the natural history of alpha-1-antitrypsin (AAT) deficiency are mostly based on highly selected patients. The aim of this study was to analyse the mortality of PiZZ individuals.

    Authors: Hanan A Tanash, Peter M Nilsson, Jan-Åke Nilsson and Eeva Piitulainen
    Citation: Respiratory Research 2010 11:44
  32. Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of th...

    Authors: Anna Selby, Bernie Clayton, Jane Grundy, Katy Pike, Kirsty Drew, Abid Raza, Ramesh Kurukulaaratchy, S Hasan Arshad and Graham Roberts
    Citation: Respiratory Research 2010 11:43
  33. We analyzed serial concentrations of multiple inflammatory mediators from serum and induced sputum obtained from patients with stable COPD and controls. The objective was to determine which proteins could be u...

    Authors: Shawn D Aaron, Katherine L Vandemheen, Timothy Ramsay, Chun Zhang, Zafrira Avnur, Tania Nikolcheva and Anthony Quinn
    Citation: Respiratory Research 2010 11:41
  34. Little is known about the influencing potential of specific characteristics on lung function in different populations. The aim of this analysis was to determine whether lung function determinants differ betwee...

    Authors: Eva Schnabel, Chih-Mei Chen, Beate Koch, Stefan Karrasch, Rudolf A Jörres, Torsten Schäfer, Claus Vogelmeier, Ralf Ewert, Christoph Schäper, Henry Völzke, Anne Obst, Stephan B Felix, H-Erich Wichmann, Sven Gläser and Joachim Heinrich
    Citation: Respiratory Research 2010 11:40
  35. Basic and clinical studies suggest that hypothalamic-pituitary-adrenal (HPA) axis is the neuroendocrine-immnue pathway that functionally regulates the chronic inflammatory disease including asthma. Our previou...

    Authors: Shui-Juan Zhang, Yang-Mei Deng, Yi-Liang Zhu, Xin-Wei Dong, Jun-Xia Jiang and Qiang-Min Xie
    Citation: Respiratory Research 2010 11:39
  36. Baroreflex allows to reduce sudden rises or falls of arterial pressure through parallel RR interval fluctuations induced by autonomic nervous system. During spontaneous breathing, the application of positive e...

    Authors: Andry Van de Louw, Claire Médigue, Yves Papelier and François Cottin
    Citation: Respiratory Research 2010 11:38
  37. Early diagnosis of pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) has potential prognostic and therapeutic implications but can be difficult due to the lack of specific clinical manifestati...

    Authors: Kyung-Hee Kim, Fabien Maldonado, Jay H Ryu, Patrick W Eiken, Thomas E Hartman, Brian J Bartholmai, Paul A Decker and Eunhee S Yi
    Citation: Respiratory Research 2010 11:37
  38. Cigarette smoking is an important risk factor for pulmonary arterial hypertension (PAH) in chronic obstructive pulmonary disease (COPD). Chymase has been shown to function in the enzymatic production of angiot...

    Authors: Tao Wang, Su-Xia Han, Shang-Fu Zhang, Yun-Ye Ning, Lei Chen, Ya-Juan Chen, Guang-Ming He, Dan Xu, Jin An, Ting Yang, Xiao-Hong Zhang and Fu-Qiang Wen
    Citation: Respiratory Research 2010 11:36
  39. Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated. The aim ...

    Authors: Geert R Van Pottelberge, Ken R Bracke, Ingel K Demedts, Kim De Rijck, Susanne M Reinartz, Cornelis M van Drunen, Geert M Verleden, Frank E Vermassen, Guy F Joos and Guy G Brusselle
    Citation: Respiratory Research 2010 11:35
  40. Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines.

    Authors: Yun-Feng Ni, Jian Wang, Xiao-Long Yan, Feng Tian, Jin-Bo Zhao, Yun-Jie Wang and Tao Jiang
    Citation: Respiratory Research 2010 11:33

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