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  1. Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death...

    Authors: L. Torre-Bouscoulet, W. R. Muñoz-Montaño, D. Martínez-Briseño, F. J. Lozano-Ruiz, R. Fernández-Plata, J. A. Beck-Magaña, C. García-Sancho, A. Guzmán-Barragán, E. Vergara, M. Blake-Cerda, L. Gochicoa-Rangel, F. Maldonado, M. Arroyo-Hernández and O. Arrieta
    Citation: Respiratory Research 2018 19:72
    Content type: Research Published on:

  2. Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory ...

    Authors: Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe…
    Citation: Respiratory Research 2018 19:71
    Content type: Research Published on:

  3. Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possibl...

    Authors: Olga Rafikova, Anup Srivastava, Ankit A. Desai, Ruslan Rafikov and Stevan P. Tofovic
    Citation: Respiratory Research 2018 19:69
    Content type: Research Published on:

  4. Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and...

    Authors: Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord and Lena Gustavsson
    Citation: Respiratory Research 2018 19:68
    Content type: Research Published on:

  5. In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we...

    Authors: Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg and Claudia A. Staab-Weijnitz
    Citation: Respiratory Research 2018 19:67
    Content type: Research Published on:

  6. Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternativ...

    Authors: Elena Mitsi, Raphael Kamng’ona, Jamie Rylance, Carla Solórzano, J. Jesus Reiné, Henry C. Mwandumba, Daniela M. Ferreira and Kondwani C. Jambo
    Citation: Respiratory Research 2018 19:66
    Content type: Letter to the Editor Published on:

  7. Corticosteroids increase the expression of β2-adrenoceptors (β2-ARs) and protect them against down-regulation. Conversely, β2-AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it ...

    Authors: Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola and Paola Rogliani
    Citation: Respiratory Research 2018 19:65
    Content type: Research Published on:

  8. The imbalance between proteases and anti-proteases is considered to contribute to the development of COPD. Our aim was to evaluate the protease MMP-9, the antiprotease TIMP-1 and the MMP-9/TIMP-1-ratio as biom...

    Authors: Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie F. Behndig, Anders Blomberg and Anne Lindberg
    Citation: Respiratory Research 2018 19:64
    Content type: Research Published on:

  9. Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencin...

    Authors: James D. Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson and Alicia Gayle
    Citation: Respiratory Research 2018 19:63
    Content type: Research Published on:

  10. Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypo...

    Authors: Alejandro A. Diaz, Carlos H. Martinez, Rola Harmouche, Thomas P. Young, Merry-Lynn McDonald, James C. Ross, Mei Lan Han, Russell Bowler, Barry Make, Elizabeth A. Regan, Edwin K. Silverman, James Crapo, Aladin M. Boriek, Gregory L. Kinney, John E. Hokanson, Raul San Jose Estepar…
    Citation: Respiratory Research 2018 19:62
    Content type: Research Published on:

  11. Obstructive sleep apnea (OSA) is highly prevalent in patients with coronary artery disease (CAD) and is associated with recurrent cardiovascular risk. However, whether treatment with continuous positive airway...

    Authors: Xiao Wang, Ying Zhang, Zhimin Dong, Jingyao Fan, Shaoping Nie and Yongxiang Wei
    Citation: Respiratory Research 2018 19:61
    Content type: Research Published on:

  12. It is unknown if the plasma lipidome is a useful tool for improving our understanding of the acute respiratory distress syndrome (ARDS). Therefore, we measured the plasma lipidome of individuals with ARDS at t...

    Authors: Michael D. Maile, Theodore J. Standiford, Milo C. Engoren, Kathleen A. Stringer, Elizabeth S. Jewell, Thekkelnaycke M. Rajendiran, Tanu Soni and Charles F. Burant
    Citation: Respiratory Research 2018 19:60
    Content type: Research Published on:

  13. Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the gene...

    Authors: Ma’en Obeidat, Guohai Zhou, Xuan Li, Nadia N. Hansel, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré and Don D. Sin
    Citation: Respiratory Research 2018 19:59
    Content type: Research Published on:

  14. Chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in world. Cigarette smoke is known to cause oxidative stress and deplete glutathione (GSH) levels. Nuclear erythroid-rel...

    Authors: Mahin Dianat, Maryam Radan, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati and Masoumeh Ahmadizadeh
    Citation: Respiratory Research 2018 19:58
    Content type: Research Published on:

  15. Gastric contents aspiration in humans has variable consequences depending on the volume of aspirate, ranging from subclinical pneumonitis to respiratory failure with up to 70% mortality. Several experimental a...

    Authors: Pedro Ayala, Jorge Torres, Raúl Vivar, Manuel Meneses, Pablo Olmos, Tamara San Martin and Gisella R. Borzone
    Citation: Respiratory Research 2018 19:57
    Content type: Research Published on:

  16. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to e...

    Authors: Maxine J. Roberts, Rebecca E. Broome, Toby C. Kent, Steven J. Charlton and Elizabeth M. Rosethorne
    Citation: Respiratory Research 2018 19:56
    Content type: Research Published on:

  17. A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, th...

    Authors: Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier and Henrik Watz
    Citation: Respiratory Research 2018 19:55
    Content type: Research Published on:

  18. In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered i...

    Authors: Alexandra McCarron, Martin Donnelley and David Parsons
    Citation: Respiratory Research 2018 19:54
    Content type: Review Published on:

  19. Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway sm...

    Authors: Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala and Kentaro Mizuta
    Citation: Respiratory Research 2018 19:53
    Content type: Research Published on:

  20. Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be ...

    Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada and Masakazu Ichinose
    Citation: Respiratory Research 2018 19:52
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2018 19:116

  21. Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative st...

    Authors: Alessandro G. Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A. Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru and Angelo Zinellu
    Citation: Respiratory Research 2018 19:51
    Content type: Review Published on:

  23. Patients with chronic obstructive pulmonary disease (COPD) experience symptoms that vary over the day. Symptoms at the start of the day might influence physical activity during the rest of the day. Therefore, ...

    Authors: Amanda R. van Buul, Marise J. Kasteleyn, Niels H. Chavannes and Christian Taube
    Citation: Respiratory Research 2018 19:49
    Content type: Research Published on:

  25. Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the ...

    Authors: Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He and Depeng Jiang
    Citation: Respiratory Research 2018 19:47
    Content type: Research Published on:

  26. Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability...

    Authors: Phuwanat Sakornsakolpat, Jarrett D. Morrow, Peter J. Castaldi, Craig P. Hersh, Yohan Bossé, Edwin K. Silverman, Ani Manichaikul and Michael H. Cho
    Citation: Respiratory Research 2018 19:46
    Content type: Research Published on:

  27. Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in bo...

    Authors: Bart de Brouwer, Marjolein Drent, Jody M. W. van den Ouweland, Petal A. Wijnen, Coline H. M. van Moorsel, Otto Bekers, Jan C. Grutters, Eric S. White and Rob Janssen
    Citation: Respiratory Research 2018 19:45
    Content type: Letter to the Editor Published on:

  28. Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...

    Authors: Valérie Besnard, Alain Calender, Diane Bouvry, Yves Pacheco, Catherine Chapelon-Abric, Florence Jeny, Hilario Nunes, Carole Planès and Dominique Valeyre
    Citation: Respiratory Research 2018 19:44
    Content type: Research Published on:

  29. Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the...

    Authors: A. Padilla-Galo, C. Olveira, L. Fernández de Rota-Garcia, I. Marco-Galve, A. J. Plata, A. Alvarez, F. Rivas-Ruiz, A. Carmona-Olveira, J. J. Cebrian-Gallardo and M. A. Martinez-Garcia
    Citation: Respiratory Research 2018 19:43
    Content type: Research Published on:

  30. Smoking is a leading cause of respiratory infections worldwide. Tobacco particulate matter disrupts iron homeostasis in the lungs and increases the iron content in the airways of smokers. The airway epithelia ...

    Authors: Luis G. Vargas Buonfiglio, Jennifer A. Borcherding, Mark Frommelt, Gavin J. Parker, Bryce Duchman, Oriana G. Vanegas Calderón, Ruth Fernandez-Ruiz, Julio E. Noriega, Elizabeth A. Stone, Alicia K. Gerke, Joseph Zabner and Alejandro P. Comellas
    Citation: Respiratory Research 2018 19:42
    Content type: Research Published on:

  31. Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD).

    Authors: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, C. Magnus Sköld and Åsa M. Wheelock
    Citation: Respiratory Research 2018 19:40
    Content type: Research Published on:

  32. Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms o...

    Authors: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, Sven Nyrén, C. Magnus Sköld and Åsa M. Wheelock
    Citation: Respiratory Research 2018 19:39
    Content type: Research Published on:

  33. Our previous screening study suggested that the cell-adhesions protein Dihydropyrimidinase-like 3 (DPYSL3) was a candidate metastatic lung cancer related molecule. This study aimed to analyze the correlation b...

    Authors: Yang Yang, Yan Jiang, Dong Xie, Ming Liu, Nan Song, Junjie Zhu, Jiang Fan and Chenfang Zhu
    Citation: Respiratory Research 2018 19:41
    Content type: Research Published on:

  34. Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). This Phase IIb study investigated...

    Authors: Edward M. Kerwin, Selwyn Spangenthal, Christine Kollar, Earl St Rose and Colin Reisner
    Citation: Respiratory Research 2018 19:38
    Content type: Research Published on:

  35. The contribution of airway remodeling in chronic obstructive pulmonary disease (COPD) has been well documented, with airway smooth muscle cell proliferation and migration playing a role in the remodeling proce...

    Authors: Xiuqin Ye, Wei Hong, Binwei Hao, Gongyong Peng, Lingmei Huang, Zhuxiang Zhao, Yumin Zhou, Mengning Zheng, Chenglong Li, Chunxiao Liang, Erkang Yi, Jinding Pu, Bing Li and Pixin Ran
    Citation: Respiratory Research 2018 19:37
    Content type: Research Published on:

  36. The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited...

    Authors: Hye Yun Park, Suh-Young Lee, Danbee Kang, Juhee Cho, Hyun Lee, Seong Yong Lim, Ho Il Yoon, Seung Won Ra, Ki Uk Kim, Yeon-Mok Oh, Don D. Sin, Sang-Do Lee and Yong Bum Park
    Citation: Respiratory Research 2018 19:36
    Content type: Research Published on:

  37. We would like to comment on the article entitled “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 stud...

    Authors: Luigi Mario Castello and Mattia Bellan
    Citation: Respiratory Research 2018 19:35
    Content type: Letter to the Editor Published on:

  38. Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers repo...

    Authors: Youhei Takahashi, Atsushi Saito, Hirofumi Chiba, Koji Kuronuma, Kimiyuki Ikeda, Tomofumi Kobayashi, Shigeru Ariki, Motoko Takahashi, Yasushi Sasaki and Hiroki Takahashi
    Citation: Respiratory Research 2018 19:34
    Content type: Research Published on:

  39. Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both ‘obese’ animal mo...

    Authors: Amanda Giesler, Manali Mukherjee, Katherine Radford, Luke Janssen and Parameswaran Nair
    Citation: Respiratory Research 2018 19:33
    Content type: Research Published on:

  40. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor progn...

    Authors: Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone and Luca Richeldi
    Citation: Respiratory Research 2018 19:32
    Content type: Review Published on:

  41. COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical ...

    Authors: Kristoffer Ostridge, Nicholas P. Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C. Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson
    Citation: Respiratory Research 2018 19:31
    Content type: Research Published on:

  42. The literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations an...

    Authors: Fernando Sergio Leitao Filho, Seung Won Ra, Andre Mattman, Robert S. Schellenberg, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Janice M. Leung, S. F. Paul Man, Shawn D. Aaron, Robert M. Reed and Don D. Sin
    Citation: Respiratory Research 2018 19:30
    Content type: Research Published on:

  43. ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

    Authors: Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand and Cornelius J. Busch
    Citation: Respiratory Research 2018 19:29
    Content type: Research Published on:

  44. Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

    Authors: Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning and Jie Cao
    Citation: Respiratory Research 2018 19:28
    Content type: Research Published on:

  45. Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

    Authors: Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng and Guodong Hu
    Citation: Respiratory Research 2018 19:27
    Content type: Research Published on:

  46. A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...

    Authors: Kate M. Johnson, Stirling Bryan, Shahzad Ghanbarian, Don D. Sin and Mohsen Sadatsafavi
    Citation: Respiratory Research 2018 19:26
    Content type: Research Published on:

  47. Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

    Authors: Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey and Toby M. Maher
    Citation: Respiratory Research 2018 19:25
    Content type: Research Published on:

  48. Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...

    Authors: Javier Milara, Gracia Hernandez, Beatriz Ballester, Anselm Morell, Inés Roger, P. Montero, Juan Escrivá, José M. Lloris, Maria Molina-Molina, Esteban Morcillo and Julio Cortijo
    Citation: Respiratory Research 2018 19:24
    Content type: Research Published on:

  49. Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

    Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps and Joanna Floros
    Citation: Respiratory Research 2018 19:23
    Content type: Research Published on:

  50. Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

    Authors: Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya and Koichi Omori
    Citation: Respiratory Research 2018 19:22
    Content type: Research Published on:
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Respiratory Research

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