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  1. Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obs...

    Authors: Andreas Scherr, Desiree M. Schumann, Meropi Karakioulaki, Léo Franchetti, Werner Strobel, Michael Zellweger, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2020 21:90

    Content type: Research

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  2. Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in th...

    Authors: Andrzej S. Swinarew, Arkadiusz J. Stanula, Jadwiga Gabor, Paweł Raif, Jarosław Paluch, Jakub Karpiński, Klaudia Kubik, Hubert Okła, Andrzej Ostrowski, Ewaryst Tkacz, Szymon Skoczyński, Zbigniew Waśkiewicz, Thomas Rosemann, Pantelis T. Nikolaidis and Beat Knechtle

    Citation: Respiratory Research 2020 21:88

    Content type: Research

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  3. Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatme...

    Authors: Henrik Watz, Jens M. Hohlfeld, Dave Singh, Jutta Beier, Zuzana Diamant, Jinming Liu, Shucheng Hua, Khalid Abd-Elaziz, Pascale Pinot, Ieuan Jones and Hanns-Christian Tillmann

    Citation: Respiratory Research 2020 21:87

    Content type: Letter to the Editor

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  4. Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism,...

    Authors: Yipeng Ding, Yixiu Yang, Quanni Li, Qiong Feng, Dongchuan Xu, Cibing Wu, Jie Zhao, Xiaoli Zhou, Huan Niu, Ping He, Jianfang Liu and Hongxia Yao

    Citation: Respiratory Research 2020 21:86

    Content type: Research

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  5. Intraoperative Extracorporeal membrane oxygenation (ECMO) is increasingly being applied as life-support for lung transplantation patients. However, factors associated with this procedure in lung transplantatio...

    Authors: Rong Zhang, Yonghao Xu, Ling Sang, Sibei Chen, Yongbo Huang, Lingbo Nong, Chun Yang, Xuesong Liu, Dongdong Liu, Yin Xi, Weiqun He, Bing Wei, Jianxing He, Yimin Li and Xiaoqing Liu

    Citation: Respiratory Research 2020 21:85

    Content type: Research

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  6. Chronic obstructive pulmonary disease (COPD) is airway inflammation characterized and low daily physical activity. Most pulmonary rehabilitation (PR) programs are often provided to stable patients, but fewer t...

    Authors: Lan-Fang Tung, Sheng-Yeh Shen, Hui-Hsuan Shih, Yen-Ting Chen, Chia-te Yen and Shu-Chuan Ho

    Citation: Respiratory Research 2020 21:84

    Content type: Research

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  7. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The car...

    Authors: Lei Gao, Dan Jiang, Xue-song Wen, Xiao-cheng Cheng, Min Sun, Bin He, Lin-na You, Peng Lei, Xiao-wei Tan, Shu Qin, Guo-qiang Cai and Dong-ying Zhang

    Citation: Respiratory Research 2020 21:83

    Content type: Research

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  8. Diabetes mellitus causes the deterioration of smooth muscle cells and interstitial matrix proteins, including collagen. Collagen and smooth muscle cells are abundant in the lungs, but the effect of diabetes on...

    Authors: Roberta Südy, Álmos Schranc, Gergely H. Fodor, József Tolnai, Barna Babik and Ferenc Peták

    Citation: Respiratory Research 2020 21:82

    Content type: Research

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  9. Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of A...

    Authors: Adrien Carla, Bruno Pereira, Hanifa Boukail, Jules Audard, Nathalie Pinol-Domenech, Manuela De Carvalho, Raiko Blondonnet, Ruoyang Zhai, Dominique Morand, Céline Lambert, Vincent Sapin, Lorraine B. Ware, Carolyn S. Calfee, Julie A. Bastarache, John G. Laffey, Nicole P. Juffermans…

    Citation: Respiratory Research 2020 21:81

    Content type: Study protocol

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  10. Adolescence is a significant period for the gender-dependent development of lung function. Prior studies have shown that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phos...

    Authors: Shadia Khan Sunny, Hongmei Zhang, Faisal I. Rezwan, Caroline L. Relton, A. John Henderson, Simon Kebede Merid, Erik Melén, Jenny Hallberg, S. Hasan Arshad, Susan Ewart and John W. Holloway

    Citation: Respiratory Research 2020 21:80

    Content type: Research

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  11. Chronic respiratory diseases constitute a considerable part in the practice of pulmonologists and primary care physicians; spirometry is integral for the diagnosis and monitoring of these diseases, yet remains...

    Authors: Konstantinos P. Exarchos, Athena Gogali, Agni Sioutkou, Christos Chronis, Sofia Peristeri and Konstantinos Kostikas

    Citation: Respiratory Research 2020 21:79

    Content type: Research

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  12. Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced n...

    Authors: Richard Tuttle, Luca Popescu, Scott Hill, Amber Slanczka, Jeffrey Jankowski, Katherine Barre, Erika Krueger, Desmond Slade, Claire Croutch, Matthew Robben, Zack Mesa, Michael Mesa and Kenneth L. Dretchen

    Citation: Respiratory Research 2020 21:78

    Content type: Research

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  13. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage. Increasing evidence shows that the microbiota plays a rol...

    Authors: Jerome Bouquet, David E. Tabor, Jonathan S. Silver, Varsha Nair, Andrey Tovchigrechko, M. Pamela Griffin, Mark T. Esser, Bret R. Sellman and Hong Jin

    Citation: Respiratory Research 2020 21:77

    Content type: Research

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  14. The mechanism for symptomatic improvement after bronchial thermoplasty (BT) is unclear, since spirometry reveals little or no change. In this study, the effects of BT on airway resistance were examined using t...

    Authors: David Langton, Kim Bennetts, Peter Noble, Virginia Plummer and Francis Thien

    Citation: Respiratory Research 2020 21:76

    Content type: Research

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  15. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement...

    Authors: Toby M. Maher, Juliet K. Simpson, Joanna C. Porter, Frederick J. Wilson, Robert Chan, Rhena Eames, Yi Cui, Sarah Siederer, Simon Parry, Julia Kenny, Robert J. Slack, Jagdeep Sahota, Lyn Paul, Peter Saunders, Philip L. Molyneaux, Pauline T. Lukey…

    Citation: Respiratory Research 2020 21:75

    Content type: Research

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  16. Since December 2019, 2019 novel coronavirus pneumonia emerged in Wuhan city and rapidly spread throughout China and even the world. We sought to analyse the clinical characteristics and laboratory findings of ...

    Authors: Gemin Zhang, Jie Zhang, Bowen Wang, Xionglin Zhu, Qiang Wang and Shiming Qiu

    Citation: Respiratory Research 2020 21:74

    Content type: Research

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  17. Interstitial lung disease (ILD) is a heterogeneous group of mainly chronic lung diseases differing in disease course and prognosis. For most subtypes, evidence on relevance and outcomes of hospitalisations is ...

    Authors: Julia Wälscher, Sabine Witt, Larissa Schwarzkopf and Michael Kreuter

    Citation: Respiratory Research 2020 21:73

    Content type: Research

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  18. Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characteri...

    Authors: Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz and Dave Singh

    Citation: Respiratory Research 2020 21:72

    Content type: Research

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  19. Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, right ventricular hypertrophy and failure. So far no effective treatment exists for this disease; hence...

    Authors: Shanshan Zhang, Xiaoli Liu, Li Li Ge, Kailin Li, Yongchao Sun, Fang Wang, Ying Han, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Chaoyue Xu, Yuan Chen, Ou chen, Zhaohua Zhang and Yun Luan

    Citation: Respiratory Research 2020 21:71

    Content type: Research

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  20. Glycopyrrolate (GP)/formoterol fumarate (FF; GFF) metered dose inhaler is a fixed-dose combination dual bronchodilator for patients with chronic obstructive pulmonary disease (COPD); however, whether the effic...

    Authors: Jinping Zheng, Jin-fu Xu, Martin Jenkins, Pryseley Nkouibert Assam, Lijiao Wang and Brian J. Lipworth

    Citation: Respiratory Research 2020 21:69

    Content type: Research

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  21. Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior thera...

    Authors: Kevin J. Anstrom, Imre Noth, Kevin R. Flaherty, Rex H. Edwards, Joan Albright, Amanda Baucom, Maria Brooks, Allan B. Clark, Emily S. Clausen, Michael T. Durheim, Dong-Yun Kim, Jerry Kirchner, Justin M. Oldham, Laurie D. Snyder, Andrew M. Wilson, Stephen R. Wisniewski…

    Citation: Respiratory Research 2020 21:68

    Content type: Study protocol

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  22. The use of electronic cigarettes (ECIGs) is increasing, but the impact of ECIG-vapor on cellular processes like inflammation or host defense are less understood. The aim of the present study was to compare the...

    Authors: Christian Herr, Konstantinos Tsitouras, Julia Niederstraßer, Christina Backes, Christoph Beisswenger, Li Dong, Loïc Guillot, Andreas Keller and Robert Bals

    Citation: Respiratory Research 2020 21:67

    Content type: Research

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  23. It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury. Melatonin exe...

    Authors: Geng-Chin Wu, Chung-Kan Peng, Wen-I Liao, Hsin-Ping Pao, Kun-Lun Huang and Shi-Jye Chu

    Citation: Respiratory Research 2020 21:65

    Content type: Research

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  24. The long-term effect of average volume-assured pressure support (AVAPS) on health-related quality of life (HRQOL) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory f...

    Authors: Doaa M. Magdy and Ahmed Metwally

    Citation: Respiratory Research 2020 21:64

    Content type: Research

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  25. Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habi...

    Authors: Sergi Pascual-Guardia, Michelle Ataya, Isabel Ramírez-Martínez, José Yélamos, Roberto Chalela, Salomé Bellido, Miguel López-Botet and Joaquim Gea

    Citation: Respiratory Research 2020 21:63

    Content type: Research

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  26. This study was to investigate of the mechanism by which histone deacetylase (HDAC) 8 inhibitor ameliorated airway hyperresponsiveness (AHR) and allergic airway inflammation.

    Authors: Meng-lu Li, Xin-ming Su, Yuan Ren, Xuan Zhao, Ling-fei Kong and Jian Kang

    Citation: Respiratory Research 2020 21:62

    Content type: Research

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  27. Pulmonary malignant neoplasms have a high worldwide morbidity and mortality, so the study of these malignancies using microRNAs (miRNAs) has attracted great interest and enthusiasm. The aim of this study was t...

    Authors: Chang-Yu Liang, Zu-Yun Li, Ting-Qing Gan, Ye-Ying Fang, Bin-Liang Gan, Wen-Jie Chen, Yi-Wu Dang, Ke Shi, Zhen-Bo Feng and Gang Chen

    Citation: Respiratory Research 2020 21:60

    Content type: Research

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  28. Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical r...

    Authors: Thomas Salaets, Margo Aertgeerts, André Gie, Janne Vignero, Derek de Winter, Yannick Regin, Julio Jimenez, Greetje Vande Velde, Karel Allegaert, Jan Deprest and Jaan Toelen

    Citation: Respiratory Research 2020 21:59

    Content type: Research

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  29. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic options. Curdione, a sesquiterpene ...

    Authors: Peng Liu, Kang Miao, Lei Zhang, Yong Mou, Yongjian Xu, Weining Xiong, Jun Yu and Yi Wang

    Citation: Respiratory Research 2020 21:58

    Content type: Research

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  30. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are characterized by uncontrolled activati...

    Authors: Gali Epstein Shochet, Elizabetha Brook, Becky Bardenstein-Wald and David Shitrit

    Citation: Respiratory Research 2020 21:56

    Content type: Research

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  31. Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients.

    Authors: Eleanor L. Axson, Kishan Ragutheeswaran, Varun Sundaram, Chloe I. Bloom, Alex Bottle, Martin R. Cowie and Jennifer K. Quint

    Citation: Respiratory Research 2020 21:54

    Content type: Review

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  32. Persistent pulmonary hypertension of the newborn (PPHN) is characterized by sustained high levels of pulmonary vascular resistance after birth with etiology unclear; Arterial blood oxygen saturation of Tibetan...

    Authors: Mingbang Wang, Deyi Zhuang, Mei Mei, Haiyan Ma, Zixiu Li, Fusheng He, Guoqiang Cheng, Guang Lin and Wenhao Zhou

    Citation: Respiratory Research 2020 21:53

    Content type: Research

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  33. Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT resp...

    Authors: Annika W. M. Goorsenberg, Julia N. S. d’Hooghe, Annelies M. Slats, Joost G. van den Aardweg, Jouke T. Annema and Peter I. Bonta

    Citation: Respiratory Research 2020 21:52

    Content type: Research

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  34. The risk of tuberculosis (TB) in patients with impaired kidney function remains unclear by different stages of renal function impairment.

    Authors: Chin-Chung Shu, Yu-Feng Wei, Yi-Chun Yeh, Hsien-Ho Lin, Chung-Yu Chen, Ping-Huai Wang, Shih-Lung Cheng, Jann-Yuan Wang and Chong-Jen Yu

    Citation: Respiratory Research 2020 21:51

    Content type: Research

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  35. Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clini...

    Authors: Sundeep S. Salvi, Bill B. Brashier, Jyoti Londhe, Kanchan Pyasi, Vandana Vincent, Shilpa S. Kajale, Sajid Tambe, Kuldeep Mandani, Arjun Nair, Sze Mun Mak, Sapna Madas, Sanjay Juvekar, Louise E. Donnelly and Peter J. Barnes

    Citation: Respiratory Research 2020 21:50

    Content type: Research

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  36. Pragmatic use of the anti-fibrotic medications pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF) in the United States (US) has not been studied and may be different from international settings...

    Authors: Colin H. Holtze, Elizabeth A. Freiheit, Susan L. Limb, John L. Stauffer, Karina Raimundo, Wayne T. Pan, Kevin R. Flaherty and Hyun J. Kim

    Citation: Respiratory Research 2020 21:48

    Content type: Research

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  37. Many patients with chronic obstructive pulmonary disease (COPD) still experience daily symptoms, exacerbations, and accelerated lung function decline, even when receiving maximal combined treatment with inhale...

    Authors: Dave Singh, Fernando J. Martinez, Henrik Watz, Thomas Bengtsson and Brian T. Maurer

    Citation: Respiratory Research 2020 21:47

    Content type: Research

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  38. Female smokers have increased risk for chronic obstructive pulmonary disease (COPD) compared with male smokers who have a similar history of cigarette smoke exposure. Tertiary lymphoid follicles are often foun...

    Authors: Anthony Tam, Naoya Tanabe, Andrew Churg, Joanne L. Wright, James C. Hogg and Don D. Sin

    Citation: Respiratory Research 2020 21:46

    Content type: Research

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  39. Ventilator-associated pneumonia (VAP) is a significant cause of mortality in the intensive care unit. Early diagnosis of VAP is important to provide appropriate treatment and reduce mortality. Developing a non...

    Authors: Chung-Yu Chen, Wei-Chi Lin and Hsiao-Yu Yang

    Citation: Respiratory Research 2020 21:45

    Content type: Research

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  40. To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and female...

    Authors: Xiaoyue Ge, Tiantian Zhu, Xinyi Zhang, Ye Liu, Yonglong Wang and Weifang Zhang

    Citation: Respiratory Research 2020 21:44

    Content type: Research

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  41. The pathophysiology of congenital cystic adenomatoid malformations (CCAM) of the lung remains poorly understood.

    Authors: Guillaume Lezmi, Shamila Vibhushan, Claudia Bevilaqua, Nicolas Crapart, Nicolas Cagnard, Naziha Khen-Dunlop, Christine Boyle-Freyssaut, Alice Hadchouel and Christophe Delacourt

    Citation: Respiratory Research 2020 21:43

    Content type: Research

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  42. Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role ...

    Authors: Javier Lázaro, Paloma Clavería, Carmen Cabrejas, José Fernando, Berta Daga, Beatriz Ordoñez, Silvia Segura, David Sanz - Rubio and José M. Marín

    Citation: Respiratory Research 2020 21:42

    Content type: Study protocol

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