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  1. Content type: Review

    Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, ...

    Authors: Christian Domingo, Oscar Palomares, David A. Sandham, Veit J. Erpenbeck and Pablo Altman

    Citation: Respiratory Research 2018 19:189

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  2. Content type: Research

    Fibrosis in severe asthma often leads to irreversible organ dysfunction. However, the mechanism that regulates fibrosis remains poorly understood. Interleukin (IL)-32 plays a role in several chronic inflammato...

    Authors: Gyong Hwa Hong, So-Young Park, Hyouk-Soo Kwon, Bo-Ram Bang, Jaechun Lee, Sang-Yeob Kim, Chan-Gi Pack, Soohyun Kim, Keun-Ai Moon, Tae-Bum Kim, Hee-Bom Moon and You Sook Cho

    Citation: Respiratory Research 2018 19:188

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  3. Content type: Research

    Streptococcus pneumoniae is a respiratory pathogen causing severe lung infection that may lead to complications such as bacteremia. Current polysaccharide vaccines have limited serotype coverage and therefore can...

    Authors: Chen-Fang Hsu, Chen-Hao Hsiao, Shun-Fu Tseng, Jian-Ru Chen, Yu-Jou Liao, Sy-Jou Chen, Chin-Sheng Lin, Huey-Kang Sytwu and Yi-Ping Chuang

    Citation: Respiratory Research 2018 19:187

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  4. Content type: Research

    Systemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a common and early complication, being the l...

    Authors: Amelia Chiara Trombetta, Stefano Soldano, Paola Contini, Veronica Tomatis, Barbara Ruaro, Sabrina Paolino, Renata Brizzolara, Paola Montagna, Alberto Sulli, Carmen Pizzorni, Vanessa Smith and Maurizio Cutolo

    Citation: Respiratory Research 2018 19:186

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  5. Content type: Research

    Preserved ratio impaired spirometry (PRISm) is an incompletely understood respiratory condition. We investigated the incidence and significant predictive factors of chronic obstructive pulmonary disease (COPD)...

    Authors: Hye Jung Park, Min Kwang Byun, Chin Kook Rhee, Kyungjoo Kim, Hyung Jung Kim and Kwang-Ha Yoo

    Citation: Respiratory Research 2018 19:185

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  6. Content type: Research

    HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of HIV on asthma prevalence in high HIV burden settings. The objective of this analysis was to compare the preval...

    Authors: Bruce J. Kirenga, Levicatus Mugenyi, Corina de Jong, J. Lucian Davis, Winceslaus Katagira, Thys van der Molen, Moses R. Kamya and Marike Boezen

    Citation: Respiratory Research 2018 19:184

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  7. Content type: Research

    Fibroblast growth factor 23 (FGF23) regulates phosphate metabolism by increasing renal phosphate excretion and decreasing 1.25-dihydroxyvitamin D synthesis. Reports about hypophosphatemia in patients with chro...

    Authors: Alexandra Stroda, Vincent Brandenburg, Ayham Daher, Christian Cornelissen, Claudia Goettsch, András Keszei and Michael Dreher

    Citation: Respiratory Research 2018 19:183

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  8. Content type: Research

    Few data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD).

    Authors: Silvia Perez-Bogerd, Wim Wuyts, Veronica Barbier, Heleen Demeyer, Alain Van Muylem, Wim Janssens and Thierry Troosters

    Citation: Respiratory Research 2018 19:182

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  9. Content type: Research

    Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural...

    Authors: Joanna C. Grogono, Clare Butler, Hooshang Izadi and Shakeeb H. Moosavi

    Citation: Respiratory Research 2018 19:181

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  10. Content type: Review

    Chronic Obstructive Pulmonary Disease (COPD) is a common, multifactorial lung disease which results in significant impairment of patients’ health and a large impact on society and health care burden. It is bel...

    Authors: Helena Crisford, Elizabeth Sapey and Robert A. Stockley

    Citation: Respiratory Research 2018 19:180

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  11. Content type: Research

    Epidemiologic studies have demonstrated associations between acetaminophen use and asthma. This investigation sought to determine whether sex modifies the acetaminophen-asthma association and whether leptin (LEP)...

    Authors: Ali H. Ziyab, Nandini Mukherjee, Ramesh J. Kurukulaaratchy, Hongmei Zhang, Susan Ewart, Hasan Arshad and Wilfried Karmaus

    Citation: Respiratory Research 2018 19:179

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  12. Content type: Research

    Classification of COPD is usually based on the severity of airflow, which may not sensitively differentiate subpopulations. Using a multiscale imaging-based cluster analysis (MICA), we aim to identify subpopul...

    Authors: Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup, Fernando J. Martinez…

    Citation: Respiratory Research 2018 19:178

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  13. Content type: Letter to the Editor

    There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled cortico...

    Authors: K. O. Tonga, G. G. King, C. S. Farah, C. Thamrin, F. S. Tang, J. Santos, P. Sharma, D. G. Chapman and B. G. Oliver

    Citation: Respiratory Research 2018 19:176

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  14. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to f...

    Authors: Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner and Melanie Königshoff

    Citation: Respiratory Research 2018 19:175

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  15. Content type: Research

    Berardinelli-Seip Congenital Generalized Lipodystrophy (BSCL) is an ultra-rare metabolic disease characterized by hypertriglyceridemia, hyperinsulinemia, hyperglycemia, hypoleptinemia, and diabetes mellitus. A...

    Authors: Jorge Luiz Dantas de Medeiros, Bruno Carneiro Bezerra, Thiago Anderson Brito de Araújo, Aquiles Sales Craveiro Sarmento, Lázaro Batista de Azevedo Medeiros, Lucien Peroni Gualdi, Maria do Socorro Luna Cruz, Thaiza Teixeira Xavier Nobre, Josivan Gomes Lima and Julliane Tamara Araújo de Melo Campos

    Citation: Respiratory Research 2018 19:173

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  16. Content type: Research

    Inhaled corticosteroids (ICS) are associated with an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD). Other factors such as severity of airflow limitation and concurre...

    Authors: Christer Janson, Gunnar Johansson, Björn Ställberg, Karin Lisspers, Petter Olsson, Dorothy L. Keininger, Milica Uhde, Florian S. Gutzwiller, Leif Jörgensen and Kjell Larsson

    Citation: Respiratory Research 2018 19:172

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  17. Content type: Research

    There is a need for non-invasive parameters that are sensitive to the development of the bronchiolitis obliterans syndrome (BOS) in lung transplantation (LTx) patients. We studied whether the pulmonary diffusi...

    Authors: Anna Winkler, Kathrin Kahnert, Jürgen Behr, Claus Neurohr, Nikolaus Kneidinger, Rudolf Hatz, Holger Dressel, Thomas Radtke and Rudolf A. Jörres

    Citation: Respiratory Research 2018 19:171

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  18. Content type: Review

    Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease of unknown etiology. Over the past decade, macrophage has been recognized to play a significant role...

    Authors: Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu and Cong-Yi Wang

    Citation: Respiratory Research 2018 19:170

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  19. Content type: Research

    Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in sta...

    Authors: Masato Watanabe, Keitaro Nakamoto, Toshiya Inui, Mitsuru Sada, Kojiro Honda, Masaki Tamura, Yukari Ogawa, Takuma Yokoyama, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii and Hajime Takizawa

    Citation: Respiratory Research 2018 19:169

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  20. Content type: Research

    Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish...

    Authors: Christer Janson, Karin Lisspers, Björn Ställberg, Gunnar Johansson, Gunilla Telg, Marcus Thuresson, Helene Nordahl Christensen and Kjell Larsson

    Citation: Respiratory Research 2018 19:168

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  21. Content type: Research

    The benefits and risks of anti-acid medication in patients with idiopathic pulmonary fibrosis (IPF) remain a topic of debate. We investigated whether use of anti-acid medication at baseline was associated with...

    Authors: Ulrich Costabel, Jürgen Behr, Bruno Crestani, Wibke Stansen, Rozsa Schlenker-Herceg, Susanne Stowasser and Ganesh Raghu

    Citation: Respiratory Research 2018 19:167

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  22. Content type: Research

    Agriculture workers are exposed to microbial component- and particulate matter-enriched organic dust aerosols. Whereas it is clear that exposure to these aerosols can lead to lung inflammation, it is not known...

    Authors: Tricia D. LeVan, Debra J. Romberger, Mohammad Siahpush, Brandon L. Grimm, Athena K. Ramos, Patrik L. Johansson, Tzeyu L. Michaud, Art J. Heires, Todd A. Wyatt and Jill A. Poole

    Citation: Respiratory Research 2018 19:166

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  23. Content type: Research

    Gastric contents aspiration is a high-risk condition for acute lung injury (ALI). Consequences range from subclinical pneumonitis to respiratory failure, depending on the volume of aspirate. A large increment ...

    Authors: Pedro Ayala, Raúl Vivar, Rebeca Montalva, Pablo Olmos, Manuel Meneses and Gisella R. Borzone

    Citation: Respiratory Research 2018 19:165

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  24. Content type: Letter to the Editor

    Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unli...

    Authors: Pasquale Caponnetto, Marilena Maglia, Gaetano Prosperini, Barbara Busà and Riccardo Polosa

    Citation: Respiratory Research 2018 19:164

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  25. Content type: Research

    Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare pulmonary disease caused by functional deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF therapy in aPAP has been report...

    Authors: Gaohong Sheng, Peng Chen, Yanqiu Wei, Jiaojiao Chu, Xiaolei Cao and Hui-Lan Zhang

    Citation: Respiratory Research 2018 19:163

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  26. Content type: Research

    Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluat...

    Authors: Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Toyofumi F. Chen-Yoshikawa, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Akihiko Yoshizawa, Yohei Oshima, Kohei Ikezoe, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Murase, Sonoko Nagai, Shigeo Muro, Toru Oga…

    Citation: Respiratory Research 2018 19:162

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  27. Content type: Research

    Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and impr...

    Authors: Sabrina Mueller, Fraence Gottschalk, Antje Groth, Wilhelmine Meeraus, Maurice Driessen, Thomas Kohlmann and Thomas Wilke

    Citation: Respiratory Research 2018 19:161

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  28. Content type: Research

    Sex differences in idiopathic pulmonary fibrosis (IPF) suggest a protective role for estrogen (E2); however, mechanistic studies in animal models have produced mixed results. Reports using cell lines have inve...

    Authors: L. Cody Smith, Santiago Moreno, Lauren Robertson, Sarah Robinson, Kristal Gant, Andrew J. Bryant and Tara Sabo-Attwood

    Citation: Respiratory Research 2018 19:160

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  29. Content type: Research

    Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significa...

    Authors: Tamás Dolinay, Chanat Aonbangkhen, William Zacharias, Edward Cantu, Jennifer Pogoriler, Alec Stablow, Gladys G. Lawrence, Yoshikazu Suzuki, David M. Chenoweth, Edward Morrisey, Jason D. Christie, Michael F. Beers and Susan S. Margulies

    Citation: Respiratory Research 2018 19:157

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  30. Content type: Research

    The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants. A family based study of predominantly smoking adu...

    Authors: Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos…

    Citation: Respiratory Research 2018 19:156

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  31. Content type: Research

    Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely unknown. This study examines whether changes in versica...

    Authors: Annie R. A. McDougall, Amanda J. Fosang, Jessica Faggian, Megan J. Wallace, Kelly J. Crossley, Timothy J. Cole and Stuart B. Hooper

    Citation: Respiratory Research 2018 19:155

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  32. Content type: Research

    The clinical-radiographic distinction between idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) is challenging. We sought to investigate the gene expression profiles of IPF and...

    Authors: Matthew J. Cecchini, Karishma Hosein, Christopher J. Howlett, Mariamma Joseph and Marco Mura

    Citation: Respiratory Research 2018 19:153

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  33. Content type: Research

    The Asthma Control Test (ACT) is widely used to assess asthma control, yet the validity and reliability of the test have not been specifically evaluated in adolescents or African-Americans. We conducted a pros...

    Authors: Allison J. Burbank, Krista Todoric, Pamela Steele, Jonathan Rosen, Haibo Zhou, Marcia Frye, Ceila E. Loughlin, Sally Ivins, Katherine Mills, Lauren Dembnicki Massey, Bryce B. Reeve and Michelle L. Hernandez

    Citation: Respiratory Research 2018 19:152

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  34. Content type: Research

    Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleoti...

    Authors: Timm Greulich, Francisco Rodríguez-Frias, Irene Belmonte, Andreas Klemmer, Claus F. Vogelmeier and Marc Miravitlles

    Citation: Respiratory Research 2018 19:151

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  35. Content type: Review

    Lung cancer ranks as the leading cause of cancer-related deaths worldwide and we performed this meta-analysis to investigate eligible studies and determine the prognostic effect of Ki-67.

    Authors: Dan-ming Wei, Wen-jie Chen, Rong-mei Meng, Na Zhao, Xiang-yu Zhang, Dan-yu Liao and Gang Chen

    Citation: Respiratory Research 2018 19:150

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  36. Content type: Review

    Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions a...

    Authors: José Alberto Rodríguez-Castillo, David Bravo Pérez, Aglaia Ntokou, Werner Seeger, Rory E. Morty and Katrin Ahlbrecht

    Citation: Respiratory Research 2018 19:148

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  37. Content type: Letter to the Editor

    It is recommended that screening for COPD be restricted to symptomatic individuals, but supporting evidence is lacking. We determined the performance of wheeze, cough, phlegm, and dyspnea in discriminating COP...

    Authors: Kate M. Johnson, Wan C. Tan, Jean Bourbeau, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:147

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  38. Content type: Research

    Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells. Bronchial epithel...

    Authors: Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight and Jason S. Debley

    Citation: Respiratory Research 2018 19:146

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  39. Content type: Research

    Specific microRNAs (miRNAs) play essential roles in airway remodeling in asthma. Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. However, ...

    Authors: Fatemeh Moheimani, Jorinke Koops, Teresa Williams, Andrew T. Reid, Philip M. Hansbro, Peter A. Wark and Darryl A. Knight

    Citation: Respiratory Research 2018 19:145

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  40. Content type: Research

    Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluatio...

    Authors: Kentaro Nakashima, Takashi Sato, Suguru Shigemori, Takeshi Shimosato, Masaharu Shinkai and Takeshi Kaneko

    Citation: Respiratory Research 2018 19:144

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  41. Content type: Research

    COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies of pneum...

    Authors: Nicholas P. Williams, Kristoffer Ostridge, Jeanne-Marie Devaster, Viktoriya Kim, Ngaire A. Coombs, Simon Bourne, Stuart C. Clarke, Stephen Harden, Ausami Abbas, Emmanuel Aris, Christophe Lambert, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson

    Citation: Respiratory Research 2018 19:143

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  42. Content type: Research

    Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research.

    Authors: Andreas Guenther, Ekaterina Krauss, Silke Tello, Jasmin Wagner, Bettina Paul, Stefan Kuhn, Olga Maurer, Sabine Heinemann, Ulrich Costabel, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol Wells, Martina Vasakova, Alberto Pesci…

    Citation: Respiratory Research 2018 19:141

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  43. Content type: Research

    Persons living with human immunodeficiency virus (PLWH) face an increased burden of chronic obstructive pulmonary disease (COPD). Repeated pulmonary infections, antibiotic exposures, and immunosuppression may ...

    Authors: Stella Xu, Amy Tsai, Marc A. Sze, Emily A. Vucic, Tawimas Shaipanich, Marianne Harris, Silvia Guillemi, Julia Yang, Sunita Sinha, Corey Nislow, Julio Montaner, Wan Lam, Stephen Lam, Don D. Sin, S. F. Paul Man and Janice M. Leung

    Citation: Respiratory Research 2018 19:140

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