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  1. Content type: Research

    N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients.

    Authors: Qian Qi, Yirepanjaing Ailiyaer, Ruijuan Liu, Yan Zhang, Caiyu Li, Mingtao Liu, Xiuxiu Wang, Lijun Jing and Yu Li

    Citation: Respiratory Research 2019 20:73

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  2. Content type: Research

    Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unk...

    Authors: Joseph Jude, Danielle Botelho, Nikhil Karmacharya, Gao Yuan Cao, William Jester and Reynold A. Panettieri Jr

    Citation: Respiratory Research 2019 20:72

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  3. Content type: Research

    Given the broad definition of an acute exacerbation of IPF, it is likely that acute exacerbations are heterogeneous in their aetiology, severity and clinical course. We used pooled data from the INPULSIS® tria...

    Authors: Michael Kreuter, Harald Koegler, Matthias Trampisch, Silke Geier and Luca Richeldi

    Citation: Respiratory Research 2019 20:71

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  4. Content type: Letter to the Editor

    Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signali...

    Authors: Alen Faiz, Maarten van den Berge, Cornelis J. Vermeulen, Nick H. T. ten Hacken, Victor Guryev and Simon D. Pouwels

    Citation: Respiratory Research 2019 20:70

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  5. Content type: Research

    Among patients with chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM) is a common comorbidity and is probably associated with increased systemic inflammation and worse prognosis. Metformin, ...

    Authors: Te-Wei Ho, Chun-Ta Huang, Yi-Ju Tsai, Angela Shin-Yu Lien, Feipei Lai and Chong-Jen Yu

    Citation: Respiratory Research 2019 20:69

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  6. Content type: Letter to the Editor

    The study by Kiranantawat et al. “Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation” highlights how “pulmonary consolidation...

    Authors: Marco Sperandeo, Anna Del Colle, Elisabettamaria Frongillo, Gaetano Rea, Lucia Dimitri, Cristiana Cipriani and Donato Lacedonia

    Citation: Respiratory Research 2019 20:68

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  7. Content type: Research

    Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related breathing disorder, characterized by excessive daytime sleepiness (EDS), paralleled by intermittent collapse of the upper airway. EDS may be...

    Authors: Csaba E. More, Csaba Papp, Szilvia Harsanyi, Rudolf Gesztelyi, Angela Mikaczo, Gabor Tajti, Laszlo Kardos, Ildiko Seres, Hajnalka Lorincz, Krisztina Csapo and Judit Zsuga

    Citation: Respiratory Research 2019 20:67

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  8. Content type: Research

    Interferon gamma (IFN-γ) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and management of respiratory diseases such as tuberculosis and pulmonar...

    Authors: Louise Sweeney, Alice P. McCloskey, Gerard Higgins, Joanne M. Ramsey, Sally-Ann Cryan and Ronan MacLoughlin

    Citation: Respiratory Research 2019 20:66

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  9. Content type: Research

    Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, al...

    Authors: Jarrett D. Morrow, Robert P. Chase, Margaret M. Parker, Kimberly Glass, Minseok Seo, Miguel Divo, Caroline A. Owen, Peter Castaldi, Dawn L. DeMeo, Edwin K. Silverman and Craig P. Hersh

    Citation: Respiratory Research 2019 20:65

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  10. Content type: Research

    A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD), although little is known about the shared genet...

    Authors: Zhaozhong Zhu, Xiaofang Wang, Xihao Li, Yifei Lin, Sipeng Shen, Cong-Lin Liu, Brain D. Hobbs, Kohei Hasegawa, Liming Liang, H. Marike Boezen, Carlos A. Camargo Jr, Michael H. Cho and David C. Christiani

    Citation: Respiratory Research 2019 20:64

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  11. Content type: Research

    Identifying subjects with chronic obstructive pulmonary disease (COPD) at high risk of exacerbation and mortality is key to aid individual management of COPD. The only FDA approved blood-based drug development...

    Authors: Sarah Rank Rønnow, Jannie Marie Bülow Sand, Lasse Løcke Langholm, Tina Manon-Jensen, Morten Asser Karsdal, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo and Diana Julie Leeming

    Citation: Respiratory Research 2019 20:63

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  12. Content type: Research

    This cohort study of patients with chronic obstructive pulmonary disease (COPD) was performed to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the Global Init...

    Authors: Se Hee Lee, Ji-Hyun Lee, Ho Il Yoon, Hye Yun Park, Tae-Hyung Kim, Kwang Ha Yoo, Yeon-Mok Oh, Ki Suk Jung, Sang-Do Lee and Sei Won Lee

    Citation: Respiratory Research 2019 20:62

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  13. Content type: Research

    COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the l...

    Authors: Peter Alter, Henrik Watz, Kathrin Kahnert, Klaus F. Rabe, Frank Biertz, Ronald Fischer, Philip Jung, Jana Graf, Robert Bals, Claus F. Vogelmeier and Rudolf A. Jörres

    Citation: Respiratory Research 2019 20:61

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  14. Content type: Research

    Symptomatic patients with chronic obstructive pulmonary disease (COPD) and low exacerbation risk still have disease instability, which can be improved with better bronchodilation. We evaluated two long-acting ...

    Authors: Ian Naya, Lee Tombs, David A. Lipson, Isabelle Boucot and Chris Compton

    Citation: Respiratory Research 2019 20:60

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  15. Content type: Research

    Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German ...

    Authors: Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F. Meyer, Joachim Kirschner…

    Citation: Respiratory Research 2019 20:59

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  16. Content type: Research

    Noninvasive high-frequency oscillatory ventilation (nHFOV), a relatively new modality, is gaining popularity despite scarce evidence. This meta-analysis was designed to evaluate the efficacy and safety of nHFO...

    Authors: Jing Li, Xiaoxia Li, Xianmei Huang and Zhiqun Zhang

    Citation: Respiratory Research 2019 20:58

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  17. Content type: Research

    Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, musc...

    Authors: Sabina A. Guler, Seo Am Hur, Scott A. Lear, Pat G. Camp and Christopher J. Ryerson

    Citation: Respiratory Research 2019 20:56

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  18. Content type: Letter to the Editor

    Data from controlled clinical studies in patients with more advanced idiopathic pulmonary fibrosis (IPF) could inform clinical practice, but they are limited, since this sub-population is usually excluded from...

    Authors: Ulrich Costabel, Carlo Albera, Marilyn K. Glassberg, Lisa H. Lancaster, Wim A. Wuyts, Ute Petzinger, Frank Gilberg, Klaus-Uwe Kirchgaessler and Paul W. Noble

    Citation: Respiratory Research 2019 20:55

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  19. Content type: Research

    Recently, lymphoid follicle-confined and circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, which was involved in anti-virus immune response. However, the dynamics ...

    Authors: Yu Shen, Qiu-xia Qu, Meng-ni Jin and Cheng Chen

    Citation: Respiratory Research 2019 20:54

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  20. Content type: Research

    In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.

    Authors: Junsong Gong, Zujun Chen, Yu Chen, Huanran Lv, Haisong Lu, Fuxia Yan, Lihuan Li, Weili Zhang and Jia Shi

    Citation: Respiratory Research 2019 20:53

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  21. Content type: Research

    Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases....

    Authors: Kristi J. Warren, John D. Dickinson, Amy J. Nelson, Todd A. Wyatt, Debra J. Romberger and Jill A. Poole

    Citation: Respiratory Research 2019 20:51

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  22. Content type: Research

    Macrophage migration inhibitory factor (MIF) makes chemokine-like functions and plays critical roles in various inflammatory diseases. This study was designed to explore the significance of MIF serum levels in...

    Authors: Qingjiang Wang, Wei Han, Junmei Niu, Bing Sun, Wei Dong and Guangpeng Li

    Citation: Respiratory Research 2019 20:50

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  23. Content type: Research

    Previous studies have shown that miR-144-3p might be a potential biomarker in non-small cell lung cancer (NSCLC). Nevertheless, the comprehensive mechanism behind the effects of miR-144-3p on the origin, diffe...

    Authors: Yu-Ji Chen, Yi-Nan Guo, Ke Shi, Hui-Mei Huang, Shu-Ping Huang, Wen-Qing Xu, Zu-Yun Li, Kang-Lai Wei, Ting-Qing Gan and Gang Chen

    Citation: Respiratory Research 2019 20:48

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  24. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of ...

    Authors: Sabine Witt, Ekaterina Krauss, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol U. Wells, Martina Vasakova, Alberto Pesci, Walter Klepetko, Werner Seeger, Bruno Crestani, Reiner Leidl, Rolf Holle, Larissa Schwarzkopf and Andreas Guenther

    Citation: Respiratory Research 2019 20:47

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  25. Content type: Research

    Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim o...

    Authors: André Becker, Giovanna Vella, Valentina Galata, Katharina Rentz, Christoph Beisswenger, Christian Herr, Jörn Walter, Sascha Tierling, Hortense Slevogt, Andreas Keller and Robert Bals

    Citation: Respiratory Research 2019 20:46

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  26. Content type: Research

    The majority of patients with asthma have the mild form of the disease. Whether mild asthma patients receive appropriate asthma medications has not received much attention in the literature. We examined the tr...

    Authors: Amir Khakban, J. Mark FitzGerald, Hamid Tavakoli, Larry Lynd, Solmaz Ehteshami-Afshar and Mohsen Sadatsafavi

    Citation: Respiratory Research 2019 20:44

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  27. Content type: Research

    There is a paucity of data from large prospective study evaluating the prognostic significance of the residual Synergy between percutaneous intervention with Taxus drug-eluting stents and cardiac surgery (SYNT...

    Authors: Yaping Zeng, Shuhan Yang, Xiao Wang, Jingyao Fan, Shaoping Nie and Yongxiang Wei

    Citation: Respiratory Research 2019 20:43

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  28. Content type: Research

    Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascula...

    Authors: Evren Caglayan, Manuela Trappiel, Arnica Behringer, Eva Maria Berghausen, Margarete Odenthal, Ernst Wellnhofer and Kai Kappert

    Citation: Respiratory Research 2019 20:42

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  29. Content type: Research

    Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The...

    Authors: Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama, Kazunori Tsunematsu and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:41

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  30. Content type: Research

    Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS u...

    Authors: Susanna S. Ng, Wilson Tam, Tat-On Chan, Kin-Wang To, Jenny Ngai, Ken K. P. Chan, Wing-Ho Yip, Rachel L. Lo, Karen Yiu, Fanny W. Ko and David S. Hui

    Citation: Respiratory Research 2019 20:40

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  31. Content type: Research

    Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Saffron has anti-inflammatory effects and may has beneficial effects on asthma.

    Authors: Marzie Zilaee, Seyed Ahmad Hosseini, Sima Jafarirad, Farhad Abolnezhadian, Bahman Cheraghian, Foroogh Namjoyan and Ataollah Ghadiri

    Citation: Respiratory Research 2019 20:39

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  32. Content type: Review

    Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of s...

    Authors: Hui-fang Li, Li-ping Yan, Kun Wang, Xiao-tong Li, Hai-xian Liu and Wei Tan

    Citation: Respiratory Research 2019 20:38

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  33. Content type: Research

    Inhaled corticosteroids reduce inflammation in asthma but chronic use may cause adverse effects. AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, has the potential of an improved ...

    Authors: Mary N. Brown, Rainard Fuhr, Jutta Beier, Hong-Lin Su, Yingxue Chen, Henrik Forsman, Ulrika Wählby Hamrén, Helen Jackson and Ajay Aggarwal

    Citation: Respiratory Research 2019 20:37

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  34. Content type: Research

    Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlyin...

    Authors: Xiaowei Xie, Jingan Zhao, Lixin Xie, Haiyan Wang, Yan Xiao, Yingjia She and Lingyun Ma

    Citation: Respiratory Research 2019 20:36

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  35. Content type: Research

    Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis in patients with idiopathic pulmonary fibrosis (IPF) has not been reported. ...

    Authors: Sung Woo Moon, Ji Soo Choi, Sang Hoon Lee, Kyung Soo Jung, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang and Song Yee Kim

    Citation: Respiratory Research 2019 20:35

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  36. Content type: Research

    After successful pulmonary endoarterectomy (PEA), patients may still suffer from exercise limitation, despite normal pulmonary vascular resistance. We sought to assess the proportion of these patients after th...

    Authors: Angelo G. Corsico, Andrea M. D’Armini, Valentina Conio, Antonio Sciortino, Maurizio Pin, Valentina Grazioli, Giulia Di Vincenzo, Rita Di Domenica, Anna Celentano, Benedetta Vanini, Amelia Grosso, Erica Gini, Federica Albicini, Vera N. Merli, Vanessa Ronzoni, Stefano Ghio…

    Citation: Respiratory Research 2019 20:34

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  37. Content type: Research

    Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investiga...

    Authors: Claudia Flexeder, Jan-Paul Zock, Deborah Jarvis, Giuseppe Verlato, Mario Olivieri, Geza Benke, Michael J. Abramson, Torben Sigsgaard, Cecilie Svanes, Kjell Torén, Dennis Nowak, Rain Jõgi, Jesús Martinez-Moratalla, Pascal Demoly, Christer Janson, Thorarinn Gislason…

    Citation: Respiratory Research 2019 20:33

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  38. Content type: Review

    Pulmonary disease is the main cause of the morbidity and mortality of patients affected by cystic fibrosis (CF). The lung pathology is dominated by excessive recruitment of neutrophils followed by an exaggerat...

    Authors: Valentino Bezzerri, Francesco Piacenza, Nicole Caporelli, Marco Malavolta, Mauro Provinciali and Marco Cipolli

    Citation: Respiratory Research 2019 20:32

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  39. Content type: Research

    The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we ...

    Authors: Farhan Shah, Karl A. Franklin, Thorbjörn Holmlund, Eva Levring Jäghagen, Diana Berggren, Sture Forsgren and Per Stål

    Citation: Respiratory Research 2019 20:31

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  40. Content type: Research

    The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to w...

    Authors: Sarah Marietta von Siemens, Rudolf A. Jörres, Jürgen Behr, Peter Alter, Johanna Lutter, Tanja Lucke, Sandra Söhler, Tobias Welte, Henrik Watz, Claus F. Vogelmeier, Franziska Trudzinski, Winfried Rief, Britta Herbig and Kathrin Kahnert

    Citation: Respiratory Research 2019 20:30

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  41. Content type: Research

    Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full v...

    Authors: Anup Das, Luigi Camporota, Jonathan G. Hardman and Declan G. Bates

    Citation: Respiratory Research 2019 20:29

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  42. Content type: Review

    Bovine surfactants are known to be clinically equivalent but it is unclear if porcine or bovine surfactants at their licensed dose should be preferred to treat respiratory distress syndrome in preterm neonates.

    Authors: Ascanio Tridente, Lucia De Martino and Daniele De Luca

    Citation: Respiratory Research 2019 20:28

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  43. Content type: Research

    Animal production workers are persistently exposed to organic dust and can suffer from a variety of respiratory disease symptoms and annual decline in lung function. The role of high mobility group box-1 (HMGB...

    Authors: Sanjana Mahadev Bhat, Nyzil Massey, Locke A. Karriker, Baljit Singh and Chandrashekhar Charavaryamath

    Citation: Respiratory Research 2019 20:27

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  44. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by continuous flow limitation and the immune system including macrophages and regulatory T lymphocytes (Tregs) is involved in COPD pathogenesis. In...

    Authors: Sheng-Wen Sun, Long Chen, Mei Zhou, Jiang-Hua Wu, Zhao-Ji Meng, Hong-Li Han, Shuai-Ying Miao, Chen-Chen Zhu and Xian-Zhi Xiong

    Citation: Respiratory Research 2019 20:26

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  45. Content type: Research

    Pesticide residues in food and environment along with airborne contaminants like endotoxins pose a tangible threat to living beings. Fipronil, a broad-spectrum insecticide at acute doses in combination with en...

    Authors: Arif Ahmad Pandit, Ravi Kumar Gandham, C. S. Mukhopadhyay, Ramneek Verma and R. S. Sethi

    Citation: Respiratory Research 2019 20:24

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