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  1. Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased effica...

    Authors: Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin and Delbert R. Dorscheid

    Citation: Respiratory Research 2021 22:65

    Content type: Research

    Published on:

  2. Beta-blockers are associated with reduced mortality in patients with cardiovascular disease but are often under prescribed in those with concomitant COPD, due to concerns regarding respiratory side-effects. We...

    Authors: Claudia Gulea, Rosita Zakeri, Vanessa Alderman, Alexander Morgan, Jack Ross and Jennifer K. Quint

    Citation: Respiratory Research 2021 22:64

    Content type: Review

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  3. The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of asthma. However, the role of mitochondr...

    Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose…

    Citation: Respiratory Research 2021 22:63

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2021 22:78

  4. Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung reducing clinical consequences of cholinergic hyperactivity. The AIRFLOW-1 study...

    Authors: Christophe Pison, Pallav L. Shah, Dirk-Jan Slebos, Vincent Ninane, Wim Janssens, Thierry Perez, Romain Kessler, Gaetan Deslee, Justin L. Garner, Jorine E. Hartman, Bruno Degano, Anna Mayr, Martin Mayse, Alexander D. Peterson and Arschang Valipour

    Citation: Respiratory Research 2021 22:62

    Content type: Research

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    The Correction to this article has been published in Respiratory Research 2021 22:83

  5. Rapid response system (RRS) is being increasingly adopted to improve patient safety in hospitals worldwide. However, predictors of survival outcome after RRS activation because of unexpected clinical deteriora...

    Authors: Jimyung Park, Yeon Joo Lee, Sang-Bum Hong, Kyeongman Jeon, Jae Young Moon, Jung Soo Kim, Byung Ju Kang, Jong-Joon Ahn, Dong-Hyun Lee, Jisoo Park, Jae Hwa Cho and Sang-Min Lee

    Citation: Respiratory Research 2021 22:60

    Content type: Research

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  6. Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.

    Authors: Wenjia Chen, Mohsen Sadatsafavi, J. Mark FitzGerald, Larry D. Lynd and Don D. Sin

    Citation: Respiratory Research 2021 22:59

    Content type: Research

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  7. An adverse role for obstructive sleep apnea (OSA) in cancer aggressiveness and mortality has recently emerged from clinical and animal studies, and the reasons have not been fully determined. Cancer stem cells...

    Authors: Shengyu Hao, Xiaodan Zhu, Zilong Liu, Xiaodan Wu, Shanqun Li, Pan Jiang and Liyan Jiang

    Citation: Respiratory Research 2021 22:58

    Content type: Research

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  8. MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants w...

    Authors: Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan and Charitharth Vivek Lal

    Citation: Respiratory Research 2021 22:57

    Content type: Research

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  9. Chronic obstructive pulmonary disease (COPD) has been proposed as a disease of accelerated aging. Several cross-sectional studies have related a shorter telomere length (TL), a marker of biological aging, with...

    Authors: E. Córdoba-Lanús, S. Cazorla-Rivero, M. A. García-Bello, D. Mayato, F. Gonzalvo, J. Ayra-Plasencia, B. Celli and C. Casanova

    Citation: Respiratory Research 2021 22:56

    Content type: Research

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  10. Which patients should receive dual therapy as initial treatment for chronic obstructive pulmonary disease (COPD) is only loosely defined. We evaluated if a lower forced expiratory volume in 1 s (FEV1) identifies ...

    Authors: Jieun Kang, Jae Seung Lee, Sei Won Lee, Jung Bok Lee and Yeon-Mok Oh

    Citation: Respiratory Research 2021 22:55

    Content type: Research

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  11. Inhaled corticosteroid (ICS) therapy for COPD should be guided by exacerbations and blood-eosinophils according to the GOLD 2020 strategy document. In the present study, we applied these recent recommendations...

    Authors: Osman Savran, Nina Godtfredsen, Torben Sørensen, Christian Jensen and Charlotte Suppli Ulrik

    Citation: Respiratory Research 2021 22:54

    Content type: Research

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  12. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. Several risk factors such as smoking, air pollution, inhaled toxins, high body mass index and infectious agents are involved in the pa...

    Authors: Shayan Mostafaei, Babak Sayad, Maryam Ebadi Fard Azar, Mohammad Doroudian, Shima Hadifar, Ava Behrouzi, Parisa Riahi, Bashdar Mahmud Hussen, Bahareh Bayat, Javid Sadri Nahand and Mohsen Moghoofei

    Citation: Respiratory Research 2021 22:53

    Content type: Review

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  13. Chinese Yunnan Province, located in the Yunnan–Guizhou Plateau, is a famous tourist paradise where acute high-altitude illness common occurs among lowland people visitors due to non-acclimatization to the acut...

    Authors: Xing Fu, Chunyan Yang, Bing Chen, Kexing Zeng, Siyuan Chen and Yi Fu

    Citation: Respiratory Research 2021 22:52

    Content type: Research

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  14. Little is known on the role of transient receptor potential ankyrin 1 (TRPA1) in fibroblast—myofibroblast transition (FMT) that can lead to airway remodeling which is a major problem for severe asthma and fibr...

    Authors: Jennifer Maries Go Yap, Takashi Ueda, Yoshihiro Kanemitsu, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Testsuya Oguri, Shinya Ugawa and Akio Niimi

    Citation: Respiratory Research 2021 22:51

    Content type: Research

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  15. The importance of vaccinations for COPD patients has been previously described. However, there is still a gap between guideline recommendations and the implementation of preventive care delivery for these pati...

    Authors: Solmaz Ehteshami-Afshar, Kristina Crothers, Benjamin Rodwin, Brett Bade, Cynthia Brandt and Kathleen M. Akgün

    Citation: Respiratory Research 2021 22:50

    Content type: Letter to the Editor

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    The Correction to this article has been published in Respiratory Research 2021 22:82

  16. Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndr...

    Authors: Karina Cuevas-Mora, Willy Roque, Hoora Shaghaghi, Bernadette R. Gochuico, Ivan O. Rosas, Ross Summer and Freddy Romero

    Citation: Respiratory Research 2021 22:49

    Content type: Research

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  17. Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to as...

    Authors: Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens and Loes E. M. Kistemaker

    Citation: Respiratory Research 2021 22:48

    Content type: Research

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  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock and Kian Fan Chung

    Citation: Respiratory Research 2021 22:47

    Content type: Correction

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    The original article was published in Respiratory Research 2021 22:10

  19. Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathoge...

    Authors: Yaping Wang, Kou Liao, Bo Liu, Chao Niu, Wenjing Zou, Lili Yang, Ting Wang, Daiyin Tian, Zhengxiu Luo, Jihong Dai, Qubei Li, Enmei Liu, Caihui Gong, Zhou Fu, Ying Li and Fengxia Ding

    Citation: Respiratory Research 2021 22:46

    Content type: Research

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  20. S100 calcium binding protein A9 (S100A9) is a pro-inflammatory alarmin associated with several inflammation-related diseases. However, the role of S100A9 in lung injury in sepsis has not been fully investigate...

    Authors: Boying Zhao, Renfu Lu, Jianjun Chen, Ming Xie, Xingji Zhao and Lingwen Kong

    Citation: Respiratory Research 2021 22:45

    Content type: Research

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  21. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung diseases with a poor prognosis. Long non-coding RNAs (lncRNAs) have been reported to be involved in IPF in several studies. However, the...

    Authors: Panpan Liu, Lei Zhao, Yuxia Gu, Meilan Zhang, Hongchang Gao and Yingxia Meng

    Citation: Respiratory Research 2021 22:44

    Content type: Research

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  22. The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) is heterogenous depending on the characterized sources of inflammation. This study aimed to evaluate COPD phenotypes a...

    Authors: Junghyun Kim, Bom Kim, So Hyeon Bak, Yeon-Mok Oh and Woo Jin Kim

    Citation: Respiratory Research 2021 22:43

    Content type: Research

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  23. Alveolar epithelial cells play an essential role in the initiation and progression of pulmonary fibrosis, and the occurrence of epithelial–mesenchymal transition (EMT) may be the early events of pulmonary fibr...

    Authors: Zhenzhen Ma, Chunyan Ma, Qingfeng Zhang, Yang Bai, Kun Mu, Xiangyuan Liu and Qingrui Yang

    Citation: Respiratory Research 2021 22:42

    Content type: Research

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  24. Childhood asthma and allergic diseases are a significant global problem. There are inconsistent findings on the associations of delivery mode, the number of children in the household and breastfeeding with chi...

    Authors: Yabin Hu, Yiting Chen, Shijian Liu, Fan Jiang, Meiqin Wu, Chonghuai Yan, Jianguo Tan, Guangjun Yu, Yi Hu, Yong Yin, Jiajie Qu, Shenghui Li and Shilu Tong

    Citation: Respiratory Research 2021 22:41

    Content type: Research

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  25. Observational data under real-life conditions in idiopathic pulmonary fibrosis (IPF) is scarce. We explored anti-fibrotic treatment, disease severity and phenotypes in patients with IPF from the Swedish IPF Re...

    Authors: Jing Gao, Dimitrios Kalafatis, Lisa Carlson, Ida H. A. Pesonen, Chuan-Xing Li, Åsa Wheelock, Jesper M. Magnusson and C. Magnus Sköld

    Citation: Respiratory Research 2021 22:40

    Content type: Research

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  26. Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 i...

    Authors: D. J. Leeming, F. Genovese, J. M. B. Sand, D. G. K. Rasmussen, C. Christiansen, G. Jenkins, T. M. Maher, J. Vestbo and M. A. Karsdal

    Citation: Respiratory Research 2021 22:38

    Content type: Commentary

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  27. Comorbidities play a key role in severe disease outcomes in COVID-19 patients. However, the literature on preexisting respiratory diseases and COVID-19, accounting for other possible confounders, is limited. T...

    Authors: Prateek Lohia, Kalyan Sreeram, Paul Nguyen, Anita Choudhary, Suman Khicher, Hossein Yarandi, Shweta Kapur and M. Safwan Badr

    Citation: Respiratory Research 2021 22:37

    Content type: Research

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  28. Control in COPD is a dynamic concept that can reflect changes in patients’ clinical status that may have prognostic implications, but there is no information about changes in control status and its long-term c...

    Authors: Myriam Calle Rubio, Juan Luis Rodriguez Hermosa, Juan P. de Torres, José María Marín, Cristina Martínez-González, Antonia Fuster, Borja G. Cosío, Germán Peces-Barba, Ingrid Solanes, Nuria Feu-Collado, Jose Luis Lopez-Campos and Ciro Casanova

    Citation: Respiratory Research 2021 22:36

    Content type: Research

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  29. Although the prevalence of bronchial asthma has been increasing worldwide since the 1970′s, the prevalence among 5-year-old children was significantly lower in 2016 than in 2001 in rural Bangladesh. We aimed t...

    Authors: Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata and Md Alfazal Khan

    Citation: Respiratory Research 2021 22:35

    Content type: Research

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  30. The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypertension (PAH). Treatment interruptions should be avoided due to the progressive nature of the disease. ...

    Authors: Hans Klose, Kelly M. Chin, Ralf Ewert, Henning Gall, Joseph Parambil, David Poch, Hans-Jürgen Seyfarth, Lene N. Axelsen, Shu-Fang Hsu Schmitz, Claudia Stein and Ioana R. Preston

    Citation: Respiratory Research 2021 22:34

    Content type: Research

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  31. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) carry significant morbidity and mortality. AECOPD treatment remains limited. High molecular weight hyaluronan (HMW-HA) is a glycosaminoglyc...

    Authors: Flavia Galdi, Claudio Pedone, Christopher A. McGee, Margaret George, Annette B. Rice, Shah S. Hussain, Kadambari Vijaykumar, Evan R. Boitet, Guillermo J. Tearney, John A. McGrath, Audrey R. Brown, Steven M. Rowe, Raffaele A. Incalzi and Stavros Garantziotis

    Citation: Respiratory Research 2021 22:30

    Content type: Research

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  32. Pulmonary rehabilitation (PR) has been proposed as an effective method for many respiratory diseases. However, the effects of exercise-based PR on asthma are currently inconclusive. This review aimed to invest...

    Authors: Zhenzhen Feng, Jiajia Wang, Yang Xie and Jiansheng Li

    Citation: Respiratory Research 2021 22:33

    Content type: Review

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  33. Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of S...

    Authors: Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Ellen Pierre de Oliveira, Jose Mara de Brito, Ellen Caroline Toledo do Nascimento, Renata Aparecida de Almeida Monteiro, Juliana Carvalho Ferreira, Carlos Roberto Ribeiro de Carvalho, Paulo Hilário do Nascimento Saldiva and Marisa Dolhnikoff

    Citation: Respiratory Research 2021 22:32

    Content type: Research

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  34. Epithelial solitary chemosensory cell (tuft cell) bitter taste signal transduction occurs through G protein coupled receptors and calcium-dependent signaling pathways. Type II taste cells, which utilize the sa...

    Authors: Michael A. Kohanski, Lauren Brown, Melissa Orr, Li Hui Tan, Nithin D. Adappa, James N. Palmer, Ronald C. Rubenstein and Noam A. Cohen

    Citation: Respiratory Research 2021 22:31

    Content type: Research

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  35. Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is rel...

    Authors: Laurent Truffaut, Lucas Demey, Anne Violette Bruyneel, Alain Roman, Stephane Alard, Nathalie De Vos and Marie Bruyneel

    Citation: Respiratory Research 2021 22:29

    Content type: Letter to the Editor

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  36. Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...

    Authors: Thomas Sonnweber, Eva-Maria Schneider, Manfred Nairz, Igor Theurl, Günter Weiss, Piotr Tymoszuk and Judith Löffler-Ragg

    Citation: Respiratory Research 2021 22:28

    Content type: Research

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  37. Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral ...

    Authors: Alexandra Arvanitaki, George Giannakoulas, Eva Triantafyllidou, Christos Feloukidis, Afroditi K. Boutou, Alexandros Garyfallos, Haralambos Karvounis and Theodoros Dimitroulas

    Citation: Respiratory Research 2021 22:27

    Content type: Research

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  38. The epithelial-mesenchymal signaling involving SHH-FOXF1, TBX4-FGF10, and TBX2 pathways is an essential transcriptional network operating during early lung organogenesis. However, precise regulatory interactio...

    Authors: Justyna A. Karolak, Tomasz Gambin, Przemyslaw Szafranski and Paweł Stankiewicz

    Citation: Respiratory Research 2021 22:26

    Content type: Research

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  39. Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in ord...

    Authors: Helgo Magnussen, Sarah Lucas, Therese Lapperre, Jennifer K. Quint, Ronald J. Dandurand, Nicolas Roche, Alberto Papi, David Price and Marc Miravitlles

    Citation: Respiratory Research 2021 22:25

    Content type: Research

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  40. When infected with Mycobacterium tuberculosis, only a small proportion of the population will develop active TB, and the role of host genetic factors in different TB infection status was not fully understood.

    Authors: Jing-Wen Ai, Hanyue Zhang, Zumo Zhou, Shanshan Weng, Heqing Huang, Sen Wang, Lingyun Shao, Yan Gao, Jing Wu, Qiaoling Ruan, Feifei Wang, Ning Jiang, Jiazhen Chen and Wenhong Zhang

    Citation: Respiratory Research 2021 22:23

    Content type: Research

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  41. Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary disease (COPD). Our previous studies have validated N...

    Authors: Dan-dan Zong, Xiang-ming Liu, Jin-hua Li, Ruo-yun Ouyang, Ying-jiao Long, Ping Chen and Yan Chen

    Citation: Respiratory Research 2021 22:22

    Content type: Research

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  42. COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVI...

    Authors: Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni, John C. Marshall and Michael A. Portman

    Citation: Respiratory Research 2021 22:20

    Content type: Research

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  43. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, ...

    Authors: Rachel Lam, Sophia Kwon, Jessica Riggs, Maria Sunseri, George Crowley, Theresa Schwartz, Rachel Zeig-Owens, Hilary Colbeth, Allison Halpren, Mengling Liu, David J. Prezant and Anna Nolan

    Citation: Respiratory Research 2021 22:19

    Content type: Research

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  44. Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship be...

    Authors: Toru Shirahata, Hideaki Sato, Sanehiro Yogi, Kaiji Inoue, Mamoru Niitsu, Tomoe Akagami, Machika Soma, Tomohiko Mio, Makoto Nagata, Satoshi Nakae, Yuki Nishida, Shigeho Tanaka, Fuminori Katsukawa and Hidetoshi Nakamura

    Citation: Respiratory Research 2021 22:18

    Content type: Research

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  45. For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the re...

    Authors: Marie-Caroline Rotty, Carey M. Suehs, Jean-Pierre Mallet, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Fanny Bertelli, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel

    Citation: Respiratory Research 2021 22:17

    Content type: Research

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  46. Some studies investigated epidemiological and clinical features of laboratory-confirmed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus causing coronavirus disease 2019 (CO...

    Authors: Giovanna E. Carpagnano, Giovanni Migliore, Salvatore Grasso, Vito Procacci, Emanuela Resta, Francesco Panza and Onofrio Resta

    Citation: Respiratory Research 2021 22:16

    Content type: Research

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