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  1. Content type: Research

    Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim o...

    Authors: André Becker, Giovanna Vella, Valentina Galata, Katharina Rentz, Christoph Beisswenger, Christian Herr, Jörn Walter, Sascha Tierling, Hortense Slevogt, Andreas Keller and Robert Bals

    Citation: Respiratory Research 2019 20:46

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  2. Content type: Research

    The majority of patients with asthma have the mild form of the disease. Whether mild asthma patients receive appropriate asthma medications has not received much attention in the literature. We examined the tr...

    Authors: Amir Khakban, J. Mark FitzGerald, Hamid Tavakoli, Larry Lynd, Solmaz Ehteshami-Afshar and Mohsen Sadatsafavi

    Citation: Respiratory Research 2019 20:44

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  3. Content type: Research

    Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascula...

    Authors: Evren Caglayan, Manuela Trappiel, Arnica Behringer, Eva Maria Berghausen, Margarete Odenthal, Ernst Wellnhofer and Kai Kappert

    Citation: Respiratory Research 2019 20:42

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  4. Content type: Research

    Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The...

    Authors: Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama, Kazunori Tsunematsu and Hiroki Takahashi

    Citation: Respiratory Research 2019 20:41

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  5. Content type: Research

    Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS u...

    Authors: Susanna S. Ng, Wilson Tam, Tat-On Chan, Kin-Wang To, Jenny Ngai, Ken K. P. Chan, Wing-Ho Yip, Rachel L. Lo, Karen Yiu, Fanny W. Ko and David S. Hui

    Citation: Respiratory Research 2019 20:40

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  6. Content type: Research

    Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Saffron has anti-inflammatory effects and may has beneficial effects on asthma.

    Authors: Marzie Zilaee, Seyed Ahmad Hosseini, Sima Jafarirad, Farhad Abolnezhadian, Bahman Cheraghian, Foroogh Namjoyan and Ataollah Ghadiri

    Citation: Respiratory Research 2019 20:39

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  7. Content type: Review

    Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of s...

    Authors: Hui-fang Li, Li-ping Yan, Kun Wang, Xiao-tong Li, Hai-xian Liu and Wei Tan

    Citation: Respiratory Research 2019 20:38

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  8. Content type: Research

    Inhaled corticosteroids reduce inflammation in asthma but chronic use may cause adverse effects. AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, has the potential of an improved ...

    Authors: Mary N. Brown, Rainard Fuhr, Jutta Beier, Hong-Lin Su, Yingxue Chen, Henrik Forsman, Ulrika Wählby Hamrén, Helen Jackson and Ajay Aggarwal

    Citation: Respiratory Research 2019 20:37

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  9. Content type: Research

    Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlyin...

    Authors: Xiaowei Xie, Jingan Zhao, Lixin Xie, Haiyan Wang, Yan Xiao, Yingjia She and Lingyun Ma

    Citation: Respiratory Research 2019 20:36

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  10. Content type: Research

    Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis in patients with idiopathic pulmonary fibrosis (IPF) has not been reported. ...

    Authors: Sung Woo Moon, Ji Soo Choi, Sang Hoon Lee, Kyung Soo Jung, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang and Song Yee Kim

    Citation: Respiratory Research 2019 20:35

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  11. Content type: Research

    After successful pulmonary endoarterectomy (PEA), patients may still suffer from exercise limitation, despite normal pulmonary vascular resistance. We sought to assess the proportion of these patients after th...

    Authors: Angelo G. Corsico, Andrea M. D’Armini, Valentina Conio, Antonio Sciortino, Maurizio Pin, Valentina Grazioli, Giulia Di Vincenzo, Rita Di Domenica, Anna Celentano, Benedetta Vanini, Amelia Grosso, Erica Gini, Federica Albicini, Vera N. Merli, Vanessa Ronzoni, Stefano Ghio…

    Citation: Respiratory Research 2019 20:34

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  12. Content type: Research

    Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investiga...

    Authors: Claudia Flexeder, Jan-Paul Zock, Deborah Jarvis, Giuseppe Verlato, Mario Olivieri, Geza Benke, Michael J. Abramson, Torben Sigsgaard, Cecilie Svanes, Kjell Torén, Dennis Nowak, Rain Jõgi, Jesús Martinez-Moratalla, Pascal Demoly, Christer Janson, Thorarinn Gislason…

    Citation: Respiratory Research 2019 20:33

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  13. Content type: Review

    Pulmonary disease is the main cause of the morbidity and mortality of patients affected by cystic fibrosis (CF). The lung pathology is dominated by excessive recruitment of neutrophils followed by an exaggerat...

    Authors: Valentino Bezzerri, Francesco Piacenza, Nicole Caporelli, Marco Malavolta, Mauro Provinciali and Marco Cipolli

    Citation: Respiratory Research 2019 20:32

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  14. Content type: Research

    The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we ...

    Authors: Farhan Shah, Karl A. Franklin, Thorbjörn Holmlund, Eva Levring Jäghagen, Diana Berggren, Sture Forsgren and Per Stål

    Citation: Respiratory Research 2019 20:31

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  15. Content type: Research

    The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to w...

    Authors: Sarah Marietta von Siemens, Rudolf A. Jörres, Jürgen Behr, Peter Alter, Johanna Lutter, Tanja Lucke, Sandra Söhler, Tobias Welte, Henrik Watz, Claus F. Vogelmeier, Franziska Trudzinski, Winfried Rief, Britta Herbig and Kathrin Kahnert

    Citation: Respiratory Research 2019 20:30

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  16. Content type: Research

    Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full v...

    Authors: Anup Das, Luigi Camporota, Jonathan G. Hardman and Declan G. Bates

    Citation: Respiratory Research 2019 20:29

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  17. Content type: Review

    Bovine surfactants are known to be clinically equivalent but it is unclear if porcine or bovine surfactants at their licensed dose should be preferred to treat respiratory distress syndrome in preterm neonates.

    Authors: Ascanio Tridente, Lucia De Martino and Daniele De Luca

    Citation: Respiratory Research 2019 20:28

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  18. Content type: Research

    Animal production workers are persistently exposed to organic dust and can suffer from a variety of respiratory disease symptoms and annual decline in lung function. The role of high mobility group box-1 (HMGB...

    Authors: Sanjana Mahadev Bhat, Nyzil Massey, Locke A. Karriker, Baljit Singh and Chandrashekhar Charavaryamath

    Citation: Respiratory Research 2019 20:27

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  19. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by continuous flow limitation and the immune system including macrophages and regulatory T lymphocytes (Tregs) is involved in COPD pathogenesis. In...

    Authors: Sheng-Wen Sun, Long Chen, Mei Zhou, Jiang-Hua Wu, Zhao-Ji Meng, Hong-Li Han, Shuai-Ying Miao, Chen-Chen Zhu and Xian-Zhi Xiong

    Citation: Respiratory Research 2019 20:26

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  20. Content type: Research

    Pesticide residues in food and environment along with airborne contaminants like endotoxins pose a tangible threat to living beings. Fipronil, a broad-spectrum insecticide at acute doses in combination with en...

    Authors: Arif Ahmad Pandit, Ravi Kumar Gandham, C. S. Mukhopadhyay, Ramneek Verma and R. S. Sethi

    Citation: Respiratory Research 2019 20:24

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  21. Content type: Research

    To determine the clinical role, safety, and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation.

    Authors: Nantaka Kiranantawat, Shaunagh McDermott, Florian J. Fintelmann, Sydney B. Montesi, Melissa C. Price, Subba R. Digumarthy and Amita Sharma

    Citation: Respiratory Research 2019 20:23

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  22. Content type: Research

    Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) minor criteria for severe community-acquired pneumonia (CAP) are of unequal weight in predicting mortality, but the major problem asso...

    Authors: Qi Guo, Wei-dong Song, Hai-yan Li, Yi-ping Zhou, Ming Li, Xiao-ke Chen, Hui Liu, Hong-lin Peng, Hai-qiong Yu, Xia Chen, Nian Liu, Zhong-dong Lü, Li-hua Liang, Qing-zhou Zhao and Mei Jiang

    Citation: Respiratory Research 2019 20:22

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    The Correction to this article has been published in Respiratory Research 2019 20:147

  23. Content type: Research

    Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction is not known. We tested whether maternal obesity alter...

    Authors: Jordan Smoothy, Alexander N. Larcombe, Emily K. Chivers, Vance B. Matthews and Shelley Gorman

    Citation: Respiratory Research 2019 20:21

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  24. Content type: Research

    Inflammatory micro-environment has been proposed to play a critical role in lung tumorigenesis. NLRP3 is known as an intracellular receptor involving inflammation and has been reported which is increasingly as...

    Authors: Li Huang, Shuyin Duan, Hua Shao, Aihua Zhang, Shuang Chen, Peng Zhang, Na Wang, Wei Wang, Yongjun Wu, Jing Wang, Hong Liu, Wu Yao, Qiao Zhang and Feifei Feng

    Citation: Respiratory Research 2019 20:20

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  25. Content type: Research

    Soluble CD14 (sCD14) shedding from CD14 could regulate T lymphocyte activation and function, which has implicated in the pathogenesis of bronchial asthma. The level of sCD14 expression is obviously increased i...

    Authors: Ting Zhou, Xiji Huang, Jixuan Ma, Yun Zhou, Yuewei Liu, Lili Xiao, Jing Yuan, Jungang Xie and Weihong Chen

    Citation: Respiratory Research 2019 20:19

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  26. Content type: Correction

    Following publication of the original article [1], we have been notified of the below corrections to the 5th paragraph in the Discussion section.

    Authors: M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río and N. A. Risebrough

    Citation: Respiratory Research 2019 20:18

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    The original article was published in Respiratory Research 2018 19:224

  27. Content type: Research

    Pirfenidone, an antifibrotic drug, slows-down the disease progression in idiopathic pulmonary fibrosis (IPF) over 12 months, however limited data on the decline of lung function and overall survival (OS) in re...

    Authors: Monika Zurkova, Eva Kriegova, Vitezslav Kolek, Vladimira Lostakova, Martina Sterclova, Vladimir Bartos, Martina Doubkova, Ilona Binkova, Michal Svoboda, Jana Strenkova, Marketa Janotova, Martina Plackova, Ladislav Lacina, Vladimir Rihak, Frantisek Petrik, Pavlina Lisa…

    Citation: Respiratory Research 2019 20:16

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  28. Content type: Research

    The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortal...

    Authors: Joshua A. Englert, Michael H. Cho, Andrew E. Lamb, Maya Shumyatcher, Diana Barragan-Bradford, Maria C. Basil, Angelica Higuera, Colleen Isabelle, Mayra Pinilla Vera, Paul B. Dieffenbach, Laura E. Fredenburgh, Joyce B. Kang, Ami S. Bhatt, Joseph H. Antin, Vincent T. Ho, Robert J. Soiffer…

    Citation: Respiratory Research 2019 20:15

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  29. Content type: Research

    Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated...

    Authors: Sriram Sridhar, Hao Liu, Tuyet-Hang Pham, Gautam Damera and Paul Newbold

    Citation: Respiratory Research 2019 20:14

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  30. Content type: Research

    Adhesion G-protein coupled receptor F5 (ADGRF5) was recently identified as an essential regulator of pulmonary surfactant homeostasis in alveolar type II cells. We previously showed that in addition to abnorma...

    Authors: Fumimasa Kubo, Donna Maretta Ariestanti, Souta Oki, Taku Fukuzawa, Ryotaro Demizu, Tomoya Sato, Rahmaningsih Mara Sabirin, Shigehisa Hirose and Nobuhiro Nakamura

    Citation: Respiratory Research 2019 20:11

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  31. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis and evaluation of early response...

    Authors: Benjamin Bondue, Amélie Castiaux, Gaetan Van Simaeys, Céline Mathey, Félicie Sherer, Dominique Egrise, Simon Lacroix, François Huaux, Gilles Doumont and Serge Goldman

    Citation: Respiratory Research 2019 20:10

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  32. Content type: Research

    We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine prod...

    Authors: Kanoko Umezawa, Tatsuya Nagano, Kazuyuki Kobayashi, Ryota Dokuni, Masahiro Katsurada, Masatsugu Yamamoto, Yoko Yoshikawa, Tohru Kataoka and Yoshihiro Nishimura

    Citation: Respiratory Research 2019 20:9

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  33. Content type: Review

    Originally, studies on exhaled droplets explored properties of airborne transmission of infectious diseases. More recently, the interest focuses on properties of exhaled droplets as biomarkers, enabled by the ...

    Authors: B. Bake, P. Larsson, G. Ljungkvist, E. Ljungström and A-C Olin

    Citation: Respiratory Research 2019 20:8

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  34. Content type: Review

    Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomark...

    Authors: Conal Hayton, Dayle Terrington, Andrew M. Wilson, Nazia Chaudhuri, Colm Leonard and Stephen J. Fowler

    Citation: Respiratory Research 2019 20:7

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  35. Content type: Research

    Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their...

    Authors: Ghaleb Khirfan, Mostafa K. Ahmed, Michael D. Faulx, Wael Dakkak, Raed A. Dweik and Adriano R. Tonelli

    Citation: Respiratory Research 2019 20:6

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  36. Content type: Research

    Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by th...

    Authors: Rosa Faner, Jarrett D. Morrow, Sandra Casas-Recasens, Suzanne M. Cloonan, Guillaume Noell, Alejandra López-Giraldo, Ruth Tal-Singer, Bruce E. Miller, Edwin K. Silverman, Alvar Agustí and Craig P. Hersh

    Citation: Respiratory Research 2019 20:5

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  37. Content type: Research

    The burden of chronic obstructive lung disease (COPD) is increasing in women, with recent evidence suggesting gender differences in disease characteristics and potentially in treatment outcomes.

    Authors: Jadwiga A. Wedzicha, Dave Singh, Ioanna Tsiligianni, Christine Jenkins, Sebastian Fucile, Robert Fogel, Steven Shen, Pankaj Goyal, Karen Mezzi and Konstantinos Kostikas

    Citation: Respiratory Research 2019 20:4

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  38. Content type: Review

    Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed...

    Authors: Jian Wang, Mengchan Zhu, Jue Pan, Cuicui Chen, Shijin Xia and Yuanlin Song

    Citation: Respiratory Research 2019 20:3

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  39. Content type: Research

    Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as h...

    Authors: Daisuke Morichika, Nobuaki Miyahara, Utako Fujii, Akihiko Taniguchi, Naohiro Oda, Satoru Senoo, Mikio Kataoka, Mitsune Tanimoto, Hiroki Kakuta, Katsuyuki Kiura, Yoshinobu Maeda and Arihiko Kanehiro

    Citation: Respiratory Research 2019 20:2

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  40. Content type: Research

    Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously been shown to improve the ability of airway macropha...

    Authors: Melanie Erriah, Kavita Pabreja, Michael Fricker, Katherine J. Baines, Louise E. Donnelly, Johan Bylund, Anna Karlsson and Jodie L. Simpson

    Citation: Respiratory Research 2019 20:1

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  41. Content type: Research

    This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer.

    Authors: Zhe Qian, Qiankun Zhang, Ying Hu, Tongmei Zhang, Jie Li, Zan Liu, Hua Zheng, Yuan Gao, Wenyun Jia, Aimin Hu, Baolan Li and Jiqing Hao

    Citation: Respiratory Research 2018 19:262

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  42. Content type: Research

    Chronic obstructive pulmonary disease (COPD) patients may experience an acute exacerbation (AECOPD) that requires hospitalisation. The length of hospital stay (LHS) has a great economic impact on the health-ca...

    Authors: Ernesto Crisafulli, Antonella Ielpo, Enric Barbeta, Adrian Ceccato, Arturo Huerta, Albert Gabarrús, Néstor Soler, Alfredo Chetta and Antoni Torres

    Citation: Respiratory Research 2018 19:261

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  43. Content type: Research

    Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revea...

    Authors: Bright Varghese, Mushira Enani, Abdulrahman Alrajhi, Sameera Al Johani, Ali Albarak, Sahar Althawadi, Noura Elkhizzi, Hawra AlGhafli, Mohammed Shoukri and Sahal Al - Hajoj

    Citation: Respiratory Research 2018 19:259

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