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  1. Content type: Review

    Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions a...

    Authors: José Alberto Rodríguez-Castillo, David Bravo Pérez, Aglaia Ntokou, Werner Seeger, Rory E. Morty and Katrin Ahlbrecht

    Citation: Respiratory Research 2018 19:148

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  2. Content type: Letter to the Editor

    It is recommended that screening for COPD be restricted to symptomatic individuals, but supporting evidence is lacking. We determined the performance of wheeze, cough, phlegm, and dyspnea in discriminating COP...

    Authors: Kate M. Johnson, Wan C. Tan, Jean Bourbeau, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:147

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  3. Content type: Research

    Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells. Bronchial epithel...

    Authors: Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight and Jason S. Debley

    Citation: Respiratory Research 2018 19:146

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  4. Content type: Research

    Specific microRNAs (miRNAs) play essential roles in airway remodeling in asthma. Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. However, ...

    Authors: Fatemeh Moheimani, Jorinke Koops, Teresa Williams, Andrew T. Reid, Philip M. Hansbro, Peter A. Wark and Darryl A. Knight

    Citation: Respiratory Research 2018 19:145

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  5. Content type: Research

    Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluatio...

    Authors: Kentaro Nakashima, Takashi Sato, Suguru Shigemori, Takeshi Shimosato, Masaharu Shinkai and Takeshi Kaneko

    Citation: Respiratory Research 2018 19:144

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  6. Content type: Research

    COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies of pneum...

    Authors: Nicholas P. Williams, Kristoffer Ostridge, Jeanne-Marie Devaster, Viktoriya Kim, Ngaire A. Coombs, Simon Bourne, Stuart C. Clarke, Stephen Harden, Ausami Abbas, Emmanuel Aris, Christophe Lambert, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson

    Citation: Respiratory Research 2018 19:143

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  7. Content type: Research

    Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research.

    Authors: Andreas Guenther, Ekaterina Krauss, Silke Tello, Jasmin Wagner, Bettina Paul, Stefan Kuhn, Olga Maurer, Sabine Heinemann, Ulrich Costabel, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol Wells, Martina Vasakova, Alberto Pesci…

    Citation: Respiratory Research 2018 19:141

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  8. Content type: Research

    Persons living with human immunodeficiency virus (PLWH) face an increased burden of chronic obstructive pulmonary disease (COPD). Repeated pulmonary infections, antibiotic exposures, and immunosuppression may ...

    Authors: Stella Xu, Amy Tsai, Marc A. Sze, Emily A. Vucic, Tawimas Shaipanich, Marianne Harris, Silvia Guillemi, Julia Yang, Sunita Sinha, Corey Nislow, Julio Montaner, Wan Lam, Stephen Lam, Don D. Sin, S. F. Paul Man and Janice M. Leung

    Citation: Respiratory Research 2018 19:140

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  9. Content type: Research

    Probiotics could prevent Pseudomonas aeruginosa colonization in lower respiratory tract (LRT) and reduced P. aeruginosa ventilator-associated pneumonia (VAP) rate. Recent studies also suggested that probiotics co...

    Authors: Xiaoling Qi, Hongping Qu, Dandan Yang, Lian Zhou, Ya-Wen He, Yuetian Yu, Jieming Qu and Jialin Liu

    Citation: Respiratory Research 2018 19:139

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  10. Content type: Research

    The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. ...

    Authors: Torsten Goldmann, Gernot Zissel, Henrik Watz, Daniel Drömann, Martin Reck, Christian Kugler, Klaus F. Rabe and Sebastian Marwitz

    Citation: Respiratory Research 2018 19:138

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  11. Content type: Research

    Trials of disease modifying therapies in Chronic Obstructive Pulmonary Disease (COPD) provide challenges for detecting physiological and patient centred outcomes. The purpose of the current study was to monito...

    Authors: Robert A. Stockley, Ross G. Edgar, Sian Starkey and Alice M. Turner

    Citation: Respiratory Research 2018 19:137

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  12. Content type: Review

    Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene, which encodes for a protein responsible for ion transport out of epithel...

    Authors: Nathan Rout-Pitt, Nigel Farrow, David Parsons and Martin Donnelley

    Citation: Respiratory Research 2018 19:136

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  13. Content type: Research

    Idiopathic pulmonary fibroelastosis (iPPFE) is a rare lung lesion characterized by pleural and subpleural parenchymal thickening due to accumulation of fibroelastotic tissue. Only recently, a few cases with a ...

    Authors: Sissel Kronborg-White, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Sara Tomassetti, Elisabeth Bendstrup and Venerino Poletti

    Citation: Respiratory Research 2018 19:135

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  14. Content type: Research

    Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association be...

    Authors: Sun Hye Shin, Hye Yun Park, Danbee Kang, Juhee Cho, Sung Ok Kwon, Joo Hun Park, Jae Seung Lee, Yeon-Mok Oh, Don D. Sin, Woo Jin Kim and Sang-Do Lee

    Citation: Respiratory Research 2018 19:134

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  15. Content type: Research

    Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onse...

    Authors: George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley and James Fingleton

    Citation: Respiratory Research 2018 19:133

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  16. Content type: Research

    Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the ex...

    Authors: John E. McDonough, Dries S. Martens, Naoya Tanabe, Farida Ahangari, Stijn E. Verleden, Karen Maes, Geert M. Verleden, Naftali Kaminski, James C. Hogg, Tim S. Nawrot, Wim A. Wuyts and Bart M. Vanaudenaerde

    Citation: Respiratory Research 2018 19:132

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  17. Content type: Research

    Cigarette smoke exposure can affect pulmonary lipid homeostasis and cause a progressive increase in pulmonary antibodies against oxidized low-density lipoproteins (OxLDL). Similarly, increased anti-OxLDL antib...

    Authors: Maude Talbot, Mélanie Hamel-Auger, Marie-Josée Beaulieu, Morgan Gazzola, Ariane Lechasseur, Sophie Aubin, Marie-Ève Paré, David Marsolais, Ynuk Bossé and Mathieu C. Morissette

    Citation: Respiratory Research 2018 19:131

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  18. Content type: Research

    Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in th...

    Authors: Carl M. Philpott, Sally Erskine, Claire Hopkins, Nirmal Kumar, Shahram Anari, Naveed Kara, Sankalp Sunkaraneni, Jaydip Ray, Allan Clark, Andrew Wilson, Sally Erskine, Carl Philpott, Allan Clark, Claire Hopkins, Alasdair Robertson, Shahzada Ahmed…

    Citation: Respiratory Research 2018 19:129

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  19. Content type: Research

    Circulating microRNAs have shown promise as non-invasive biomarkers and predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic data have not shown excellent prediction of ...

    Authors: Alvin T. Kho, Michael J. McGeachie, Kip G. Moore, Jody M. Sylvia, Scott T. Weiss and Kelan G. Tantisira

    Citation: Respiratory Research 2018 19:128

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  20. Content type: Research

    Pulmonary fibrosis is a progressive and lethal disease characterized by damage to the lung parenchyma with excess extracellular matrix deposition. The involvement of endothelial cells in fibrosis development i...

    Authors: Shinpei Kato, Naoki Inui, Akio Hakamata, Yuzo Suzuki, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe and Takafumi Suda

    Citation: Respiratory Research 2018 19:127

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  21. Content type: Research

    Airway epithelial cells and alveolar macrophages (AMs) are the first line of defense in the lung during infection. Toll-like receptor (TLR) agonists have been extensively used to define the regulation of infla...

    Authors: Reem Al Mubarak, Nicole Roberts, Robert J. Mason, Scott Alper and Hong Wei Chu

    Citation: Respiratory Research 2018 19:126

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  22. Content type: Research

    Primary ciliary dyskinesia can result from a number of different ciliary defects that adversely affect ciliary function resulting markedly reduced or absent mucociliary clearance. Improvement in diagnostic tes...

    Authors: Chris O’Callaghan, Andrew Rutman, Gwyneth Williams, Neeta Kulkarni, Joseph Hayes and Robert A. Hirst

    Citation: Respiratory Research 2018 19:125

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  23. Content type: Review

    The Human Viral Challenge (HVC) model has, for many decades, helped in the understanding of respiratory viruses and their role in disease pathogenesis. In a controlled setting using small numbers of volunteers...

    Authors: Rob Lambkin-Williams, Nicolas Noulin, Alex Mann, Andrew Catchpole and Anthony S. Gilbert

    Citation: Respiratory Research 2018 19:123

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  24. Content type: Research

    Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vit...

    Authors: Lu Wang, Nannan Zhang, Yi Zhang, Jingen Xia, Qingyuan Zhan and Chen Wang

    Citation: Respiratory Research 2018 19:122

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  25. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a progressive disease and a composite endpoint could be an indicator of treatment effect on disease worsening. This post-hoc analysis assessed whether indacatero...

    Authors: Antonio R. Anzueto, Konstantinos Kostikas, Karen Mezzi, Steven Shen, Michael Larbig, Francesco Patalano, Robert Fogel, Donald Banerji and Jadwiga A. Wedzicha

    Citation: Respiratory Research 2018 19:121

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  26. Content type: Research

    Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed that PDGF-BB contracts pulmonary veins (PVs) a...

    Authors: Annette D. Rieg, Said Suleiman, Carolin Anker, Eva Verjans, Rolf Rossaint, Stefan Uhlig and Christian Martin

    Citation: Respiratory Research 2018 19:120

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  27. Content type: Research

    Antimicrobial treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains controversial. In some cases AECOPD are caused by microorganisms that are resistant to treatments recom...

    Authors: Cristina Estirado, Adrian Ceccato, Monica Guerrero, Arturo Huerta, Catia Cilloniz, Olivia Vilaró, Albert Gabarrús, Joaquim Gea, Ernesto Crisafulli, Nestor Soler and Antoni Torres

    Citation: Respiratory Research 2018 19:119

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  28. Content type: Research

    Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Ye...

    Authors: Nuria Toledo-Pons, Guillaume Noell, Andreas Jahn, Amanda Iglesias, Maria Antonia Duran, Julio Iglesias, Angel Rios, Sergio Scrimini, Rosa Faner, Orlando Gigirey, Alvar Agustí and Borja G. Cosío

    Citation: Respiratory Research 2018 19:118

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  29. Content type: Letter to the Editor

    Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated tha...

    Authors: Stella Xu, Emily A. Vucic, Tawimas Shaipanich, Stephen Lam, Wan Lam, Julio S. Montaner, Don D. Sin, S. F. Paul Man and Janice M. Leung

    Citation: Respiratory Research 2018 19:117

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  30. Content type: Correction

    Figure 2 of this original publication was incorrectly formatted. The updated Fig. 2 is published in this correction article [1].

    Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2018 19:116

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    The original article was published in Respiratory Research 2018 19:52

  31. Content type: Research

    Exposure to high levels of oxygen (hyperoxia) after birth leads to lung injury. Our aims were to investigate the modulation of myeloid cell sub-populations and the reduction of fibrosis in the lungs following ...

    Authors: Ali Al-Rubaie, Andrea F. Wise, Foula Sozo, Robert De Matteo, Chrishan S. Samuel, Richard Harding and Sharon D. Ricardo

    Citation: Respiratory Research 2018 19:114

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  32. Content type: Review

    Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology. The heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergi...

    Authors: Andrea Matucci, Alessandra Vultaggio, Enrico Maggi and Ismail Kasujee

    Citation: Respiratory Research 2018 19:113

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  33. Content type: Letter to the Editor

    Although Th2 driven inflammation is present in COPD, it is not clearly elucidated which COPD patients are affected. Since periostin is associated with Th2 driven inflammation and inhaled corticosteroid (ICS)-r...

    Authors: O. A. Carpaij, F. O. W. Muntinghe, M. B. Wagenaar, J. W. Habing, W. Timens, H. A. M. Kerstjens, M. C. Nawijn, L. I. Z. Kunz, P. S. Hiemstra, G. W. Tew, C. T. J. Holweg, C. A. Brandsma and M. van den Berge

    Citation: Respiratory Research 2018 19:112

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  34. Content type: Research

    Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between...

    Authors: Sangeetha Vishweswaraiah, Leema George, Natarajan Purushothaman and Koustav Ganguly

    Citation: Respiratory Research 2018 19:92

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  35. Content type: Research

    Parthenolide (PTL) is a natural molecule isolated from Tanacetum parthenium that exhibits excellent anti-inflammatory and antitumor activities. Pulmonary fibrosis (PF), especially idiopathic pulmonary fibrosis (I...

    Authors: Xiao-he Li, Ting Xiao, Jia-huan Yang, Yuan Qin, Jing-jing Gao, Hui-juan Liu and Hong-gang Zhou

    Citation: Respiratory Research 2018 19:111

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  36. Content type: Research

    Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid withi...

    Authors: Kathrin Kahnert, Peter Alter, Tobias Welte, Rudolf M. Huber, Jürgen Behr, Frank Biertz, Henrik Watz, Robert Bals, Claus F. Vogelmeier and Rudolf A. Jörres

    Citation: Respiratory Research 2018 19:110

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  37. Content type: Research

    Increasing evidence suggests that human antigen R (HuR) is involved in the epithelial-mesenchymal transition (EMT) process of several diseases. However, the role of HuR in EMT in the airway epithelial cells of...

    Authors: Jian Sun, Xianmin Gu, Nan Wu, Pengju Zhang, Yi Liu and Shujuan Jiang

    Citation: Respiratory Research 2018 19:109

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  38. Content type: Research

    Interleukin(IL)-33 is an epithelial alarmin important for eosinophil maturation, activation and survival. The aim of this study was to examine the association between IL-33, its receptor expression and airway ...

    Authors: Damian Tworek, Sebastian Majewski, Karolina Szewczyk, Justyna Kiszałkiewicz, Zofia Kurmanowska, Paweł Górski, Ewa Brzeziańska-Lasota, Piotr Kuna and Adam Antczak

    Citation: Respiratory Research 2018 19:108

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  39. Content type: Research

    Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification ...

    Authors: Kevin Ni, Amar Gill, Victor Tseng, Andrew M. Mikosz, Kengo Koike, Erica L. Beatman, Cassie Y. Xu, Danting Cao, Fabienne Gally, Kara J. Mould, Karina A. Serban, Kelly S. Schweitzer, Keith L. March, William J. Janssen, Eva Nozik-Grayck, Stavros Garantziotis…

    Citation: Respiratory Research 2018 19:107

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  40. Content type: Research

    As a way to determine markers of infection or disease informing disease management, and to reveal disease-associated immune mechanisms, this study sought to measure antibody and T cell responses against key lu...

    Authors: Fathia G. Jaat, Sajidah F. Hasan, Audrey Perry, Sharon Cookson, Santosh Murali, John D. Perry, Clare V. Lanyon, Anthony De Soyza and Stephen M. Todryk

    Citation: Respiratory Research 2018 19:106

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  41. Content type: Letter to the Editor

    In idiopathic pulmonary fibrosis (IPF), home monitoring experiences are limited, not yet real-time available nor implemented in daily care. We evaluated feasibility and potential barriers of a new home monitor...

    Authors: C. C. Moor, M. Wapenaar, J. R. Miedema, J. J. M. Geelhoed, P. P. Chandoesing and M. S. Wijsenbeek

    Citation: Respiratory Research 2018 19:105

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  42. Content type: Research

    Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been ...

    Authors: Elga Bandeira, Helena Oliveira, Johnatas D. Silva, Rubem F. S. Menna-Barreto, Christina M. Takyia, Jung S. Suk, Kenneth W. Witwer, Michael E. Paulaitis, Justin Hanes, Patricia R. M. Rocco and Marcelo M. Morales

    Citation: Respiratory Research 2018 19:104

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  43. Content type: Research

    Extracellular adenosine triphosphate (ATP) is up-regulated in the airways of patients with chronic obstructive pulmonary disease (COPD), resulting in increased inflammation, bronchoconstriction, and cough. Alt...

    Authors: Elisabet Aliagas, Mariana Muñoz-Esquerre, Ester Cuevas, Oriol Careta, Daniel Huertas, Marta López-Sánchez, Ignacio Escobar, Jordi Dorca and Salud Santos

    Citation: Respiratory Research 2018 19:103

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  44. Content type: Research

    Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as poten...

    Authors: Liran Levy, Stephen C. Juvet, Kristen Boonstra, Lianne G. Singer, Sassan Azad, Betty Joe, Marcelo Cypel, Shaf Keshavjee and Tereza Martinu

    Citation: Respiratory Research 2018 19:102

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  45. Content type: Research

    Patients with interstitial lung diseases (ILD) have impaired health-related quality of life (HRQL). Little is known about the applicability of the disease-specific King’s Brief Interstitial Lung Disease questi...

    Authors: Boglárka Lilla Szentes, Michael Kreuter, Thomas Bahmer, Surinder S. Birring, Martin Claussen, Julia Waelscher, Reiner Leidl and Larissa Schwarzkopf

    Citation: Respiratory Research 2018 19:101

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