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  1. Asthma is a complex condition largely attributed to the interactions among genes and environments as a heterogeneous phenotype. Obesity is significantly associated with asthma development, and genetic studies ...

    Authors: Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Xiao Chang, Frank D. Mentch, Kenny Nguyen, Lifeng Tian, Joseph Glessner, Patrick M. A. Sleiman and Hakon Hakonarson
    Citation: Respiratory Research 2022 23:116
  2. Published studies suggest physical recovery from the COVID-19 is complex, with many individuals experiencing persistent symptoms. There is a paucity of data investigating the longer-term trajectory of physical...

    Authors: Kate O’Brien, Liam Townsend, Joanne Dowds, Ciarán Bannan, Parthiban Nadarajan, Brian Kent, Niamh Murphy, Gráinne Sheill, Ignacio Martin-Loeches and Emer Guinan
    Citation: Respiratory Research 2022 23:115
  3. Non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) infections are frequently associated with exacerbations of chronic obstructive pulmonary disease (COPD). Results were reported with a tw...

    Authors: Ilaria Galgani, Margherita Annaratone, Daniela Casula, Gennaro Di Maro, Michel Janssens, Annaelisa Tasciotti, Tino Schwarz, Murdo Ferguson and Ashwani Kumar Arora
    Citation: Respiratory Research 2022 23:114
  4. With prevalent global air pollution, individuals with certain genetic predispositions and sensitivities are at of higher risk of developing respiratory symptoms including chronic cough. Studies to date have re...

    Authors: Michael Yoon, Min Hyung Ryu, Ryan D. Huff, Maria G. Belvisi, Jaclyn Smith and Chris Carlsten
    Citation: Respiratory Research 2022 23:113
  5. HPS-1 is a genetic type of Hermansky-Pudlak syndrome (HPS) with highly penetrant pulmonary fibrosis (HPSPF), a restrictive lung disease that is similar to idiopathic pulmonary fibrosis (IPF). Hps1ep/ep (pale ear)...

    Authors: Shachar Abudi-Sinreich, Steven P. Bodine, Tadafumi Yokoyama, Nathanial J. Tolman, Michal Tyrlik, Lauren C. Testa, Chen G. Han, Heidi M. Dorward, Stephen M. Wincovitch, Yair Anikster, William A. Gahl, Resat Cinar, Bernadette R. Gochuico and May Christine V. Malicdan
    Citation: Respiratory Research 2022 23:112
  6. While the prevalence and disease burden of bronchiectasis are increasing, data in the world’s largest population are lacking. We aimed to investigate the prevalence and disease burden of bronchiectasis in Chin...

    Authors: Jingnan Feng, Lina Sun, Xiaoyan Sun, Lu Xu, Lili Liu, Guozhen Liu, Jinxi Wang, Pei Gao, Siyan Zhan, Yahong Chen, Shengfeng Wang and Yongchang Sun
    Citation: Respiratory Research 2022 23:111
  7. Retinoid-related orphan receptor-α (RORα) and autophagy dysregulation are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD), but little is known regarding their association. We in...

    Authors: Hak-Su Kim, Chang Hyeok An, Danielle Teller, Su-Jin Moon, Gi Won Hwang and Jin Woo Song
    Citation: Respiratory Research 2022 23:110
  8. Chronic obstructive pulmonary disease (COPD) guidelines recommend reserving triple therapy of inhaled corticosteroid (ICS), long-acting β2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) for patients ...

    Authors: Claus F. Vogelmeier, Heinrich Worth, Roland Buhl, Carl-Peter Criée, Eva Gückel and Peter Kardos
    Citation: Respiratory Research 2022 23:109
  9.  The main long-term complication after lung transplantation is bronchiolitis obliterans syndrome (BOS), a deadly condition in which neutrophils may play a critical pathophysiological role. Recent studies show ...

    Authors: Jesper M. Magnusson, Petrea Ericson, Sara Tengvall, Marit Stockfelt, Bettina Brundin, Anders Lindén and Gerdt C. Riise
    Citation: Respiratory Research 2022 23:108
  10. Pulmonary arteriovenous malformations (PAVMs) are rare but cause various manifestations. Although the diameter of feeding arteries has been linked to treatment decisions, relationships among the characteristic...

    Authors: Xu Ma, Ling-Ling Li, Dong Yu, Bing Jie and Sen Jiang
    Citation: Respiratory Research 2022 23:107
  11. Chronic obstructive pulmonary disease (COPD) receives low awareness and is undertreated in China. Understanding the burden and treatment of COPD across the nation is important for improving quality of care for...

    Authors: Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Yahong Chen, Wenhua Jian, Hongyan Shang and Chen Wang
    Citation: Respiratory Research 2022 23:106

    The Correction to this article has been published in Respiratory Research 2022 23:159

  12. Quantitative computed tomography (QCT) analysis may serve as a tool for assessing the severity of coronavirus disease 2019 (COVID-19) and for monitoring its progress. The present study aimed to assess the as...

    Authors: Ying Su, Ze-song Qiu, Jun Chen, Min-jie Ju, Guo-guang Ma, Jin-wei He, Shen-ji Yu, Kai Liu, Fleming Y. M. Lure, Guo-wei Tu, Yu-yao Zhang and Zhe Luo
    Citation: Respiratory Research 2022 23:105
  13. Ionizing radiation (IR) can induce pulmonary fibrosis by causing epithelial mesenchymal transition (EMT), but the exact mechanism has not been elucidated. To investigate the molecular mechanism of how radiatio...

    Authors: Ziyan Yan, Xingkun Ao, Xinxin Liang, Zhongmin Chen, Yuhao Liu, Ping Wang, Duo Wang, Zheng Liu, Xiaochang Liu, Jiaojiao Zhu, Shenghui Zhou, Pingkun Zhou and Yongqing Gu
    Citation: Respiratory Research 2022 23:104
  14. The Internet is commonly used by patients to acquire health information. To date, no studies have evaluated the quality of information available on YouTube regarding lymphangioleiomyomatosis (LAM). Our aim was...

    Authors: Finn M. Wilkens, Claudia Ganter, Katharina Kriegsmann, Heinrike Wilkens, Nicolas Kahn, Gillian C. Goobie, Christopher J. Ryerson and Michael Kreuter
    Citation: Respiratory Research 2022 23:103
  15. The use of vital signs monitoring in the early recognition of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) post-hospital discharge is limited. This study investigated whether continu...

    Authors: Grace Hawthorne, Matthew Richardson, Neil J. Greening, Dale Esliger, Samuel Briggs-Price, Emma J. Chaplin, Lisa Clinch, Michael C. Steiner, Sally J. Singh and Mark W. Orme
    Citation: Respiratory Research 2022 23:102
  16. Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refrac...

    Authors: Sonal Mistry, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E. Scott, Marc Chikhani, John G. Laffey, Jonathan G. Hardman, Luigi Camporota and Declan G. Bates
    Citation: Respiratory Research 2022 23:101
  17. Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal lung disease. In addition to dense fibrous tissue, abnormal angiogenesis is also an important feature of IPF. Pigment epithelium-derived ...

    Authors: Xichun Qin, Caili Jia, Jingtian Liang, Jiali Chen, Xiucheng Liu, Zhixiang Chao, Hao Qin, Yanliang Yuan, Zhiwei Liu, Zhongming Zhang, Hongyan Dong and Hao Zhang
    Citation: Respiratory Research 2022 23:100
  18. Chronic cough is prevalent in the clinic. The existing therapies are mostly limited to medical treatment, with poor curative effects and serious side effects. Studies have suggested that the right dorsolateral...

    Authors: Peijun Gui, Lin Wang, Liya Guo, Chunwei Wu, Bo Zhang, Chen Chen and Ying Xie
    Citation: Respiratory Research 2022 23:99
  19. Spirometry quality assurance is a challenging task across levels of healthcare tiers, especially in primary care. Deep learning may serve as a support tool for enhancing spirometry quality. We aimed to develop...

    Authors: Yimin Wang, Yicong Li, Wenya Chen, Changzheng Zhang, Lijuan Liang, Ruibo Huang, Jianling Liang, Dandan Tu, Yi Gao, Jinping Zheng and Nanshan Zhong
    Citation: Respiratory Research 2022 23:98
  20. Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These featu...

    Authors: Auyon J. Ghosh, Brian D. Hobbs, Jeong H. Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P. Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise…
    Citation: Respiratory Research 2022 23:97
  21. Clinically differentiating preinvasive lesions (atypical adenomatous hyperplasia, AAH and adenocarcinoma in situ, AIS) from invasive lesions (minimally invasive adenocarcinomas, MIA and invasive adenocarcinoma...

    Authors: Minghui Zhu, Zhen Yang, Miaoyu Wang, Wei Zhao, Qiang Zhu, Wenjia Shi, Hang Yu, Zhixin Liang and Liangan Chen
    Citation: Respiratory Research 2022 23:96
  22. The distribution of allergens has geographic characteristics. Local epidemiological data provides evidence-based strategies for the prevention and management of allergic diseases. Age and sex differences may e...

    Authors: Xiaolan Ying, Xinyi Qi, Yong Yin, Hongmei Wang, Hao Zhang, Haohua Jiang, Lin Yang and Jinhong Wu
    Citation: Respiratory Research 2022 23:95
  23. Before the pandemic of coronavirus disease (COVID-19), rapidly improving acute respiratory distress syndrome (ARDS), mostly defined by early extubation, had been recognized as an increasingly prevalent subphen...

    Authors: Evdokia Gavrielatou, Katerina Vaporidi, Vasiliki Tsolaki, Nikos Tserlikakis, George E. Zakynthinos, Eleni Papoutsi, Aikaterini Maragkuti, Athina G. Mantelou, Dimitrios Karayiannis, Zafeiria Mastora, Dimitris Georgopoulos, Epaminondas Zakynthinos, Christina Routsi, Spyros G. Zakynthinos, Edward J. Schenck, Anastasia Kotanidou…
    Citation: Respiratory Research 2022 23:94
  24. Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer globally, with average age of cancer patients becoming younger gradually. It is of significance to gain a comprehensive understandin...

    Authors: Pei Zhang, Li Li, Bing Wang, Xu Ran, Shengrong Yang, Yujie Luo, Yunhe Li, Zhenghong Wang, Yi Liu and Bing Zhu
    Citation: Respiratory Research 2022 23:93
  25. Mechanical ventilation is often employed to facilitate breathing in patients suffering from respiratory illnesses and disabilities. Despite the benefits, there are risks associated with ventilator-induced lung...

    Authors: C. A. Mariano, S. Sattari, K. A. M. Quiros, T. M. Nelson and M. Eskandari
    Citation: Respiratory Research 2022 23:92

    The Correction to this article has been published in Respiratory Research 2022 23:130

  26. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high morbidity and limited treatment options. Type 2 diabetes mellitus (T2DM) is a common comorbid illness among patients with IPF...

    Authors: Taylor T. Teague, Stephanie R. Payne, Bryan T. Kelly, Timothy M. Dempsey, Rozalina G. McCoy, Lindsey R. Sangaralingham and Andrew H. Limper
    Citation: Respiratory Research 2022 23:91
  27. Global distributions and trends of the risk-attributable burdens of chronic obstructive pulmonary disease (COPD) have rarely been systematically explored. To guide the formulation of targeted and accurate stra...

    Authors: Jiahua Zou, Tao Sun, Xiaohui Song, Ye-Mao Liu, Fang Lei, Ming-Ming Chen, Ze Chen, Peng Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Yunman Luo, Ping Wang and Hongliang Li
    Citation: Respiratory Research 2022 23:90
  28. Patients suffering from combined obstructive and interstitial lung disease (O-ILD) represent a pathological entity which still has to be well clinically described. The aim of this descriptive and explorative s...

    Authors: Julien Guiot, Monique Henket, Anne-Noëlle Frix, Fanny Gester, Marie Thys, Laurie Giltay, Colin Desir, Catherine Moermans, Makon-Sébastien Njock, Paul Meunier, Jean-Louis Corhay and Renaud Louis
    Citation: Respiratory Research 2022 23:89
  29. Most phenotyping paradigms in sarcoidosis are based on expert opinion; however, no paradigm has been widely adopted because of the subjectivity in classification. We hypothesized that cluster analysis could be...

    Authors: Nancy W. Lin, Jaron Arbet, Margaret M. Mroz, Shu-Yi Liao, Clara I. Restrepo, Annyce S. Mayer, Li Li, Briana Q. Barkes, Sarah Schrock, Nabeel Hamzeh, Tasha E. Fingerlin, Nichole E. Carlson and Lisa A. Maier
    Citation: Respiratory Research 2022 23:88
  30. Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than ...

    Authors: Jane Chanda Kabwe, Hirofumi Sawada, Yoshihide Mitani, Hironori Oshita, Naoki Tsuboya, Erquan Zhang, Junko Maruyama, Yoshiki Miyasaka, Hideyoshi Ko, Kazunobu Oya, Hiromasa Ito, Noriko Yodoya, Shoichiro Otsuki, Hiroyuki Ohashi, Ryuji Okamoto, Kaoru Dohi…
    Citation: Respiratory Research 2022 23:87
  31. Endoplasmic reticulum (ER) stress is involved in the pathological process of pulmonary fibrosis, including IPF. It affects a broad scope of cellular types during pulmonary fibrosis but the role in epithelial-m...

    Authors: Xiaoyu Yang, Wei Sun, Xiaoyan Jing, Qian Zhang, Hui Huang and Zuojun Xu
    Citation: Respiratory Research 2022 23:86
  32. In the INBUILD trial in patients with progressive fibrosing interstitial lung diseases (ILDs), nintedanib reduced the rate of decline in forced vital capacity compared with placebo, with side-effects that were...

    Authors: Vincent Cottin, Fernando J. Martinez, R. Gisli Jenkins, John A. Belperio, Hideya Kitamura, Maria Molina-Molina, Inga Tschoepe, Carl Coeck, Dirk Lievens and Ulrich Costabel
    Citation: Respiratory Research 2022 23:85
  33. Insomnia is highly prevalent among patients with allergic disease and asthma; however, few studies have investigated their causal relationship. We aim to explore the causal association between insomnia and all...

    Authors: Rong Li, Yiting Chen, Anda Zhao, Lili Huang, Zichong Long, Wenhui Kang, Yong Yin, Shilu Tong, Yongmei Guo and Shenghui Li
    Citation: Respiratory Research 2022 23:84
  34. The 6-min walking distance (6MWD) test is a useful tool to obtain a measure of functional exercise capacity. However, reference equations have been mainly based on selected populations or small samples. The pu...

    Authors: Lucia Cazzoletti, Maria Elisabetta Zanolin, Gianluigi Dorelli, Pietro Ferrari, Luca Giuseppe Dalle Carbonare, Ernesto Crisafulli, Mulubirhan Assefa Alemayohu, Mario Olivieri, Giuseppe Verlato and Marcello Ferrari
    Citation: Respiratory Research 2022 23:83
  35. A small number of studies suggested that air pollution was associated with idiopathic pulmonary fibrosis (IPF) exacerbation, incidence and mortality. However, no studies to date were conducted in regions where...

    Authors: Lirong Liang, Yutong Cai, Baolei Lyu, Di Zhang, Shuilian Chu, Hang Jing, Kazem Rahimi and Zhaohui Tong
    Citation: Respiratory Research 2022 23:81
  36. In elderly populations, paracetamol may be used regularly for conditions such as osteoarthritis. Paracetamol has been associated with respiratory disease through a proposed mechanism of glutathione depletion a...

    Authors: Thu-Lan Kelly, Michael Ward, Nicole L. Pratt, Emmae Ramsay, Marianne Gillam and Elizabeth E. Roughead
    Citation: Respiratory Research 2022 23:80
  37. Respiratory modalities applied at the end of life may affect the burden of distressing symptoms and quality of dying and death (QODD) among patients with end-stage interstitial lung disease (ILD); however, the...

    Authors: Takafumi Koyauchi, Yuzo Suzuki, Kazuki Sato, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Koshi Yokomura, Shiro Imokawa, Hidenori Nakamura, Tatsuya Morita and Takafumi Suda
    Citation: Respiratory Research 2022 23:79
  38. Dry powder (DP) synthetic lung surfactant may be an effective means of noninvasive delivery of surfactant therapy to premature infants supported with nasal continuous positive airway pressure (nCPAP) in low-re...

    Authors: Frans J. Walther, Alan J. Waring, Monicah Otieno and Robert M. DiBlasi
    Citation: Respiratory Research 2022 23:78
  39. There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O2 desaturation during exe...

    Authors: Kang-Yun Lee, Sheng-Ming Wu, Hsiao-Yun Kou, Kuan-Yuan Chen, Hsiao-Chi Chuang, Po-Hao Feng, Kian Fan Chung, Kazuhiro Ito, Tzu-Tao Chen, Wei-Lun Sun, Wen-Te Liu, Chien-Hua Tseng and Shu-Chuan Ho
    Citation: Respiratory Research 2022 23:77
  40. Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supp...

    Authors: Jef Serré, Carolien Mathyssen, Tom Tanjeko Ajime, Tobias Heigl, Lieve Verlinden, Karen Maes, Annemieke Verstuyf, Didier Cataldo, Jeroen Vanoirbeek, Bart Vanaudenaerde, Wim Janssens and Ghislaine Gayan-Ramirez
    Citation: Respiratory Research 2022 23:76
  41. Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP...

    Authors: Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou and Shaoxi Cai
    Citation: Respiratory Research 2022 23:75
  42. A genetic predisposition can lead to the rare disease pulmonary arterial hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable PAH. However, as of today 15 further PAH genes have ...

    Authors: Christina A. Eichstaedt, Zoe Saßmannshausen, Memoona Shaukat, Ding Cao, Panagiota Xanthouli, Henning Gall, Natascha Sommer, Hossein-Ardeschir Ghofrani, Hans-Jürgen Seyfarth, Marianne Lerche, Michael Halank, Janina Kleymann, Nicola Benjamin, Satenik Harutyunova, Benjamin Egenlauf, Katrin Milger…
    Citation: Respiratory Research 2022 23:74
  43. For patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung damage. In this study, we investigated the role of NOX4 using NOX4 knock...

    Authors: Sang Hoon Lee, Mi Hwa Shin, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim and Moo Suk Park
    Citation: Respiratory Research 2022 23:73
  44. Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyreti...

    Authors: Astrid Monfort, Alexia Rivas, Rishika Banydeen, Jocelyn Inamo, Karim Farid and Remi Neviere
    Citation: Respiratory Research 2022 23:72
  45. Pneumonia is a major contributor to hospital admission for patients with chronic obstructive pulmonary disease (COPD). However, evidence for acute effects of ambient air pollution exposure on pneumonia hospita...

    Authors: Wenfeng Lu, Qi Tian, Ruijun Xu, Chenghui Zhong, Lan Qiu, Han Zhang, Chunxiang Shi, Yuewei Liu and Yun Zhou
    Citation: Respiratory Research 2022 23:71
  46. Particular matter 2.5 (PM2.5) is one of the most important air pollutant, and it is positively associated with the development of chronic obstructive pulmonary disease (COPD). However, the precise underlying m...

    Authors: Hongjiao Yu, Yingnan Lin, Yue Zhong, Xiaolan Guo, Yuyin Lin, Siqi Yang, Jinglin Liu, Xinran Xie, Yaowei Sun, Dong Wang, Bing Li, Pixin Ran and Jianwei Dai
    Citation: Respiratory Research 2022 23:70
  47. Chronic obstructive pulmonary disease (COPD) is a leading cause of death in adults that may have origins in early lung development. It is a complex disease, influenced by multiple factors including genetic var...

    Authors: Annika Röhl, Seung Han Baek, Priyadarshini Kachroo, Jarrett D. Morrow, Kelan Tantisira, Edwin K. Silverman, Scott T. Weiss, Amitabh Sharma, Kimberly Glass and Dawn L. DeMeo
    Citation: Respiratory Research 2022 23:69
  48. Patient hospitalized for coronavirus disease 2019 (COVID-19) pulmonary infection can have sequelae such as impaired exercise capacity. We aimed to determine the frequency of long-term exercise capacity limitat...

    Authors: Bruno Ribeiro Baptista, Thomas d’Humières, Frédéric Schlemmer, Inès Bendib, Grégoire Justeau, Lara Al-Assaad, Mouna Hachem, Rebecca Codiat, Benjamin Bardel, Laure Abou Chakra, Thibaut Belmondo, Etienne Audureau, Sophie Hue, Armand Mekontso-Dessap, Geneviève Derumeaux and Laurent Boyer
    Citation: Respiratory Research 2022 23:68
  49. Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 1...

    Authors: Paola Faverio, Fabrizio Luppi, Paola Rebora, Gabriele D’Andrea, Anna Stainer, Sara Busnelli, Martina Catalano, Giuseppe Modafferi, Giovanni Franco, Anna Monzani, Stefania Galimberti, Paolo Scarpazza, Elisa Oggionni, Monia Betti, Tiberio Oggionni, Federica De Giacomi…
    Citation: Respiratory Research 2022 23:65

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