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  1. Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (...

    Authors: Longyu Shan, Liang Zhang, Xiaolei Zhu, Zhilin Wang, Shaohan Fang, Junfeng Lin, Jianweng Wang, Ning Li, Hongming Liu, Xiaowen Zhang, Yihui Feng, Jingwei Liu, Jianyun Pan, Guanzhi Ye, Xiuyi Yu, Amanda Tufman…
    Citation: Respiratory Research 2022 23:293
    Content type: Research Published on:

  2. Although corticosteroid therapy with dose tapering is the most commonly used treatment for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), there is no consensus on the tapering regimen. This stud...

    Authors: Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa and Yosuke Yamamoto
    Citation: Respiratory Research 2022 23:291
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2023 24:107

  3. Plexiform lesions, which have a dynamic appearance in structure and cellular composition, are the histological hallmark of severe pulmonary arterial hypertension in humans. The pathogenesis of the lesion devel...

    Authors: Feng-Jin Shao, Xiao-Ling Guo, Jia-Xue Xu, Rui Liu, Dan-Yue Li, Qing-Hao Li, Ting Zhou, Cun Fang and Xun Tan
    Citation: Respiratory Research 2022 23:290
    Content type: Research Published on:

  4. Asthma is one of the most common chronic diseases that affects more than 300 million people worldwide. Though most asthma can be well controlled, individuals with severe asthma experience recurrent exacerbatio...

    Authors: Mengling Xia, Fei Xu, Hangqi Ni, Qing Wang, Ruhui Zhang, Yafang Lou and Jianying Zhou
    Citation: Respiratory Research 2022 23:289
    Content type: Research Published on:

  5. Although cardiovascular comorbidities negatively impact survival in patients with bronchiectasis, there is limited evidence to recommend exercise in this population. We aimed to evaluate whether exercise habit...

    Authors: Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon and Hyun Lee
    Citation: Respiratory Research 2022 23:288
    Content type: Research Published on:

  6. Two opposing B cell subsets have been defined based on their cytokine profile: IL-6 producing effector B cells (B-effs) versus IL-10 producing regulatory B cells (B-regs) that respectively positively or negati...

    Authors: Merel Jacobs, Sven Verschraegen, Bihiyga Salhi, Jasper Anckaert, Pieter Mestdagh, Guy G. Brusselle and Ken R. Bracke
    Citation: Respiratory Research 2022 23:287
    Content type: Research Published on:

  7. The role of micro RNAs (miRNAs) in asthma remains unclear. In this study, we examined the role of miRNA in targeting FOXO1 in asthma. Results showed that miR-493-5p was one of the differentially expressed miRN...

    Authors: Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu and Zhengrong Chen
    Citation: Respiratory Research 2022 23:286
    Content type: Research Published on:

  8. Ventilatory power is a novel index which could reflect both ventilation efficiency and peripheral blood flow. However, its clinical value in pulmonary hypertension (PH) is rarely discussed. In the present stud...

    Authors: Xin Li, Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Qin Luo and Zhihong Liu
    Citation: Respiratory Research 2022 23:285
    Content type: Research Published on:

  9. The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of...

    Authors: Sébastien Puigrenier, Jonathan Giovannelli, Nicolas Lamblin, Pascal De Groote, Marie Fertin, Jean-François Bervar, Antoine Lamer, Jean-Louis Edmé, Marie-Hélène Balquet, Vincent Sobanski, David Launay, Éric Hachulla and Sébastien Sanges
    Citation: Respiratory Research 2022 23:284
    Content type: Research Published on:

  10. Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive...

    Authors: Ferenc Peták, Gergely H. Fodor, Álmos Schranc, Roberta Südy, Ádám L. Balogh, Barna Babik, André Dos Santos Rocha, Sam Bayat, Davide Bizzotto, Raffaele L. Dellacà and Walid Habre
    Citation: Respiratory Research 2022 23:283
    Content type: Research Published on:

  11. Loss of muscle mass and function are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Acute exacerbations, in turn, significantly contribute to upgrade these systemic co...

    Authors: Carme Casadevall, Antonio Sancho-Muñoz, Ignacio Vicente, Sergi Pascual-Guardia, Mireia Admetlló and Joaquim Gea
    Citation: Respiratory Research 2022 23:282
    Content type: Research Published on:

  12. Genes involved in lung development may become dysregulated in adult life and contribute to the pathogenesis of lung diseases. Multiple genes regulate lung development, including Forkhead box protein P1-4 (FoxP...

    Authors: Alexis Andreas, Abby Maloy, Toru Nyunoya, Yingze Zhang and Divay Chandra
    Citation: Respiratory Research 2022 23:281
    Content type: Research Published on:

  13. Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subj...

    Authors: Hélène Salvator, Aristine Cheng, Lindsey B. Rosen, Peter R. Williamson, John E. Bennett, Anuj. Kashyap, Li Ding, Kyung J. Kwon-Chung, Ho Namkoong, Christa S. Zerbe and Steven M. Holland
    Citation: Respiratory Research 2022 23:280
    Content type: Research Published on:

  14. Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs a...

    Authors: Fang Yi, Chen Zhan, Baojuan Liu, Hu Li, Jianmeng Zhou, Jiaman Tang, Wen Peng, Wei Luo, Qiaoli Chen and Kefang Lai
    Citation: Respiratory Research 2022 23:279
    Content type: Research Published on:

  15. SARS-CoV-2 pre-existing T-cell immune reactivity can be present in some people. A general perturbation of the main peripheral lymphocyte subsets has been described in severe COVID-19 patients, but very few stu...

    Authors: Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Tahmina Mirashirova, Timur Muratov and Dimitri Poddighe
    Citation: Respiratory Research 2022 23:278
    Content type: Correspondence Published on:

  16. Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with poor treatment options. However, most mouse models of COPD produce a primarily emphysematous disease not recapitulating clinicall...

    Authors: Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju and Steven M. Rowe
    Citation: Respiratory Research 2022 23:277
    Content type: Research Published on:

  17. Monitoring vaccine effectiveness (VE) remains a priority for epidemiological research throughout the COVID-19 pandemic. VE against infection declines with the emergence of new SARS-CoV-2 variants of concern (V...

    Authors: Anton Barchuk, Anna Bulina, Mikhail Cherkashin, Natalia Berezina, Tatyana Rakova, Darya Kuplevatskaya, Dmitriy Skougarevskiy and Artemiy Okhotin
    Citation: Respiratory Research 2022 23:276
    Content type: Research Published on:

  18. Hypersensitivity pneumonitis (HP) is an interstitial lung disease characterized by antigen-triggered neutrophilic exacerbations. Although CD4+ T cells are sufficient for HP pathogenesis, this never translated int...

    Authors: Olivier Courtemanche, Carole-Ann Huppé, Pascale Blais Lecours, Ophélie Lerdu, Joanny Roy, Jean-François Lauzon-Joset, Marie-Renée Blanchet, Mathieu C. Morissette and David Marsolais
    Citation: Respiratory Research 2022 23:275
    Content type: Research Published on:

  19. The recommendation of PCI for limited-stage small cell lung cancer (LS-SCLC) is primarily based on evidence from the pre-magnetic resonance imaging (MRI) era. However, as MRI accuracy improves and stereotactic...

    Authors: Yu Chen, Yao Wang, Fei Ren, Zhaoqin Huang, Bingxu Tan, Zhonghua Zhao, Xinshuang Yu, Peng Dong, Jinming Yu and Xiangjiao Meng
    Citation: Respiratory Research 2022 23:274
    Content type: Research Published on:

  20. We examined the association of non-cigarette tobacco use on chronic obstructive pulmonary disease (COPD) risk in the Population Assessment of Tobacco and Health (PATH) Study.

    Authors: Laura M. Paulin, Michael J. Halenar, Kathryn C. Edwards, Kristin Lauten, Cassandra A. Stanton, Kristie Taylor, Dorothy Hatsukami, Andrew Hyland, Todd MacKenzie, Martin C. Mahoney, Ray Niaura, Dennis Trinidad, Carlos Blanco, Wilson M. Compton, Lisa D. Gardner, Heather L. Kimmel…
    Citation: Respiratory Research 2022 23:273
    Content type: Research Published on:

  21. Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free ...

    Authors: Eva M. Becker-Pelster, Michael G. Hahn, Martina Delbeck, Lisa Dietz, Jörg Hüser, Johannes Kopf, Thomas Kraemer, Tobias Marquardt, Thomas Mondritzki, Johannes Nagelschmitz, Sylvia M. Nikkho, Philippe V. Pires, Hanna Tinel, Gerrit Weimann, Frank Wunder, Peter Sandner…
    Citation: Respiratory Research 2022 23:272
    Content type: Research Published on:

  22. Spirometry reference values differ by race/ethnicity, which is controversial. We evaluated the effect of race-specific references on prevalence of lung function impairment and its relation to breathlessness an...

    Authors: Magnus Ekström and David Mannino
    Citation: Respiratory Research 2022 23:271
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2023 24:41

  23. The therapeutic effect of umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in combination with pirfenidone (PFD) on pulmonary fibrosis in mice and its possible mechanism were investigated.

    Authors: Xian Wu, Hao Gou, Ou Zhou, Huijun Qiu, Hanmin Liu, Zhou Fu and Lina Chen
    Citation: Respiratory Research 2022 23:270
    Content type: Research Published on:

  24. The defects and imbalance in lung repair and structural maintenance contribute to the pathogenesis of chronic obstructive pulmonary diseases (COPD), yet the molecular mechanisms that regulate lung repair proce...

    Authors: Tian Jiang, Weiping Hu, Shaoyuan Zhang, Changhao Ren, Siyun Lin, Zhenyu Zhou, Hao Wu, Jun Yin and Lijie Tan
    Citation: Respiratory Research 2022 23:269
    Content type: Research Published on:

  25. North Africa and Middle East (NAME) has an increasing burden of chronic respiratory diseases (CRDs); however, a systematic understanding of the distribution and trends is not available. We aimed to report the ...

    Authors: Aida Fallahzadeh, Yeganeh Sharifnejad Tehrani, Ali Sheikhy, Seyyed-Hadi Ghamari, Esmaeil Mohammadi, Sahar Saeedi Moghaddam, Zahra Esfahani, Maryam Nasserinejad, Parnian Shobeiri, Mohammad-Mahdi Rashidi, Nazila Rezaei, Mahsa Heidari-Foroozan, Negar Rezaei, Bagher Larijani and Farshad Farzadfar
    Citation: Respiratory Research 2022 23:268
    Content type: Research Published on:

  26. Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar com...

    Authors: Miguel J. Divo, José M. Marin, Ciro Casanova, Carlos Cabrera Lopez, Victor M. Pinto-Plata, Marta Marin-Oto, Francesca Polverino, Juan P. de-Torres, Dean Billheimer and Bartolome R. Celli
    Citation: Respiratory Research 2022 23:267
    Content type: Research Published on:

  27. Quadriceps muscle weakness and reduced exercise tolerance are prevalent and associated with a worse prognosis in patients with cystic fibrosis (CF). The one-minute sit-to-stand test (1STST) has been proposed t...

    Authors: Sophie Hardy, Silvia Berardis, Anne-Sophie Aubriot, Gregory Reychler and Sophie Gohy
    Citation: Respiratory Research 2022 23:266
    Content type: Research Published on:

  28. Air pollutants can activate low-grade subclinical inflammation which further impairs respiratory health. We aimed to investigate the role of polygenic susceptibility to chronic air pollution-induced subclinica...

    Authors: Sara Kress, Claudia Wigmann, Qi Zhao, Christian Herder, Michael J. Abramson, Holger Schwender and Tamara Schikowski
    Citation: Respiratory Research 2022 23:265
    Content type: Research Published on:

  29. Severe acute respiratory infections (SARI) are the most common infectious causes of death. Previous work regarding mortality prediction models for SARI using machine learning (ML) algorithms that can be useful...

    Authors: Johannes Leiner, Vincent Pellissier, Sebastian König, Sven Hohenstein, Laura Ueberham, Irit Nachtigall, Andreas Meier-Hellmann, Ralf Kuhlen, Gerhard Hindricks and Andreas Bollmann
    Citation: Respiratory Research 2022 23:264
    Content type: Research Published on:

  30. Persistent symptoms after initial COVID-19 infection are common and are frequently referred to by the umbrella terms “post-COVID syndrome” and “long COVID”. The sheer number of affected patients pose an increa...

    Authors: Lucas M. Kimmig, Zvonimir A. Rako, Stefanie Ziegler, Manuel J. Richter, Ashkan Tolou G.S., Fritz Roller, Friedrich Grimminger, István Vadász, Werner Seeger, Susanne Herold, Khodr Tello and Ulrich Matt
    Citation: Respiratory Research 2022 23:263
    Content type: Research Published on:

  31. While optimizing spirometry is a challenge for lung function labs, long-term variability if any between IOS (impulse oscillometry) parameters and spirometry is not clearly known in stable COPD (chronic obstruc...

    Authors: Jianhua Xu, Xingxing Sun, Hanqing Zhu, Yuan Cao, Bigyan Pudasaini, Wenlan Yang, Jinming Liu and Jian Guo
    Citation: Respiratory Research 2022 23:262
    Content type: Research Published on:

  32. Respiratory diseases represent a global health burden. Because research on therapeutic strategies of airway diseases is essential, the technique of precision-cut lung slices (PCLS) has been developed and widel...

    Authors: Sarah Marie Nußbaum, Julia Krabbe, Svenja Böll, Aaron Babendreyer and Christian Martin
    Citation: Respiratory Research 2022 23:261
    Content type: Research Published on:

  33. It has been a long-held consensus that immune reactions primarily mediate the pathology of chronic obstructive pulmonary disease (COPD), and that exosomes may participate in immune regulation in COPD. However,...

    Authors: Yanli Pei, Yuxi Wei, Boshizhang Peng, Mengqi Wang, Wei Xu, Zhe Chen, Xindi Ke and Lei Rong
    Citation: Respiratory Research 2022 23:260
    Content type: Research Published on:

  34. Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung fu...

    Authors: Chun-Chun Gau, Hsin-Ju Lee, Hung-Yi Lu, Chao-Yi Wu, Hsin-Yi Huang, Hui-Ju Tsai and Tsung-Chieh Yao
    Citation: Respiratory Research 2022 23:259
    Content type: Research Published on:

  35. Fluticasone furoate/vilanterol trifenatate (FF/VI) is an inhaled therapy for the treatment of asthma, with a prolonged duration of anti-inflammatory and bronchodilatory action. This study investigated the glob...

    Authors: Peter Daley-Yates, Brian Keppler, Amanda Baines, George Bardsley and James Fingleton
    Citation: Respiratory Research 2022 23:258
    Content type: Research Published on:

  36. Bronchial artery embolisation (BAE) is an effective treatment option to control haemoptysis in primary lung cancer. However, no studies have investigated optimal embolisation material for BAE in lung cancer pa...

    Authors: Jae Hwan Lee, Chang Jin Yoon, Yun Su Jung, Won Seok Choi, Chong-ho Lee and Guy Mok Lee
    Citation: Respiratory Research 2022 23:257
    Content type: Research Published on:

  37. During the COVID-19 pandemic in The Netherlands, critically ill ventilated COVID-19 patients were transferred not only between hospitals by ambulance but also by the Helicopter Emergency Medical Service (HEMS)...

    Authors: Cornelis Slagt, Eduard Johannes Spoelder, Marijn Cornelia Theresia Tacken, Maartje Frijlink, Sjoerd Servaas, Guus Leijte, Lucas Theodorus van Eijk and Geert Jan van Geffen
    Citation: Respiratory Research 2022 23:256
    Content type: Research Published on:

  38. The benefit of prompt vs delayed treatment initiation with inhaled long-acting bronchodilators in reducing exacerbations in chronic obstructive pulmonary disease (COPD) is unclear. This study aimed to investig...

    Authors: Hideyasu Yamada, Isao Matsumoto, Naoyuki Makita, Yoshifumi Arita, Nobuya Hayashi, Kurena Mitsuoka, Naoki Tashiro and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:255
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2022 23:304

  39. Asthma is the commonest chronic respiratory tract disease in children. In low-income countries, challenges exist in asthma diagnosis. In surveys done in children, the prevalence of ‘asthma’ defined by symptoms...

    Authors: P. Magwenzi, S. Rusakaniko, E. N. Sibanda and F. Z. Gumbo
    Citation: Respiratory Research 2022 23:254
    Content type: Review Published on:

  40. To tested the ability of N-myc and STAT interactor (NMI) levels in patients with community-acquired pneumonia (CAP) to predict the severity of the disease.

    Authors: Wanying Zhang, Hui Zhou, Mengyuan Cen, Wei Ouyang, Jie Chen, Lexin Xia, Xiuhui Lin, Jinliang Liu, Teng He and Feng Xu
    Citation: Respiratory Research 2022 23:253
    Content type: Research Published on:

  41. Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been...

    Authors: Mellissa Gaudet, Maria Plesa, Andrea Mogas, Nour Jalaleddine, Qutayba Hamid and Saba Al Heialy
    Citation: Respiratory Research 2022 23:252
    Content type: Review Published on:

  42. Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA d...

    Authors: Yahui Liu and Guochao Shi
    Citation: Respiratory Research 2022 23:251
    Content type: Review Published on:

  43. No personalized prediction model or standardized algorithm exists to identify those at high risk of death among severe community-acquired pneumonia (SCAP) patients with chronic obstructive pulmonary disease (C...

    Authors: Dong Huang, Dingxiu He, Linjing Gong, Rong Yao, Wen Wang, Lei Yang, Zhongwei Zhang, Qiao He, Zhenru Wu, Yujun Shi and Zongan Liang
    Citation: Respiratory Research 2022 23:250
    Content type: Research Published on:

  44. Acute respiratory distress syndrome (ARDS) is a life-threatening disease caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a dearth of drug applications that can be used t...

    Authors: Funda Terzi, Beste Demirci, İrfan Çınar, Mohammad Alhilal and Huseyin Serkan Erol
    Citation: Respiratory Research 2022 23:249
    Content type: Research Published on:

  45. Single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPAR-γ; gene: PPARG) and oxidative stress genes are associated with asthma risk. However, whether such variants modulate...

    Authors: Clarus Leung, Min Hyung Ryu, Anette Kocbach Bølling, Danay Maestre-Batlle, Christopher F. Rider, Anke Hüls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor and Chris Carlsten
    Citation: Respiratory Research 2022 23:248
    Content type: Research Published on:

  46. The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects, and low CC16 serum levels have been associated with both risk and progression of COPD, yet the interaction between smoking ...

    Authors: Kelli C. Gribben, Jill A. Poole, Amy J. Nelson, Paraskevi A. Farazi, Christopher S. Wichman, Art J. Heires, Debra J. Romberger and Tricia D. LeVan
    Citation: Respiratory Research 2022 23:247
    Content type: Research Published on:

  47. Hypoxic pulmonary hypertension (HPH) is a common complication of chronic lung disease, which severely affects the survival and prognosis of patients. Several recent reports have shown that DNA damage and repai...

    Authors: Ying-ying Liu, Wei-yun Zhang, Meng-lan Zhang, Yu-ji Wang, Xi-yan Ma, Jung-hong Jiang, Ran Wang and Da-xiong Zeng
    Citation: Respiratory Research 2022 23:246
    Content type: Research Published on:

  48. A feasible and economical bronchoscopic navigation method in guiding peripheral pulmonary nodule biopsy is lacking.

    Authors: Chang-Hao Zhong, Zhu-Quan Su, Wei-Zhan Luo, Wan-Yuan Rao, Jia-Xin Feng, Chun-Li Tang, Yu Chen, Xiao-Bo Chen, Ming-Yue Fan and Shi-Yue Li
    Citation: Respiratory Research 2022 23:245
    Content type: Research Published on:

  49. Epithelial–mesenchymal transition (EMT) is one of the mechanisms of airway remodeling in chronic asthma. Interleukin (IL)-24 has been implicated in the promotion of tissue fibrosis, and increased IL-24 levels ...

    Authors: Kang-ni Feng, Ping Meng, Xiao-ling Zou, Min Zhang, Hai-ke Li, Hai-ling Yang, Hong-tao Li and Tian-tuo Zhang
    Citation: Respiratory Research 2022 23:244
    Content type: Research Published on:

  50. To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to the Cartwright Classification (CC) and Amst...

    Authors: Weijun Huang, Xiaoting Wang, Chong Xu, Huajun Xu, Huaming Zhu, Suru Liu, Jianyin Zou, Jian Guan, Hongliang Yi and Shankai Yin
    Citation: Respiratory Research 2022 23:240
    Content type: Research Published on:
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