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  1. Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. Lung function measurement is a key step i...

    Authors: Eline Bonnardel, Renaud Prevel, Marilyne Campagnac, Marielle Dubreuil, Roger Marthan, Patrick Berger and Isabelle Dupin
    Citation: Respiratory Research 2019 20:211
    Content type: Research Published on:

  2. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and asthma are associated with a variety of precipitating factors including infection. This study assessed the infective viral etiologies b...

    Authors: Fanny Wai-san Ko, Paul Kay-sheung Chan, Renee W. Y. Chan, Ka-Pang Chan, April Ip, Angela Kwok, Jenny Chun-li Ngai, So-Shan Ng, Chan Tat On and David Shu-cheong Hui
    Citation: Respiratory Research 2019 20:210
    Content type: Research Published on:

  3. Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capaci...

    Authors: Marie-Caroline Rotty, Jean-Pierre Mallet, Carey M. Suehs, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel
    Citation: Respiratory Research 2019 20:209
    Content type: Letter to the Editor Published on:

  4. Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Pr...

    Authors: R. James White, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Ronald J. Oudiz, Vallerie V. McLaughlin, Marius M. Hoeper, Ekkehard Grünig, Hossein-Ardeschir Ghofrani, Murali M. Chakinala, Joan A. Barberà, Christiana Blair, Jonathan Langley and Adaani E. Frost
    Citation: Respiratory Research 2019 20:208
    Content type: Research Published on:

  5. The diagnostic yield of peripheral pulmonary lesions has significantly increased with the use of radial endobronchial ultrasound with guide sheath within the lesion. Here, we retrospectively evaluated factors ...

    Authors: Yoichi Nishii, Taro Yasuma, Kentaro Ito, Yuta Suzuki, Fumiaki Watanabe, Tetsu Kobayashi, Kota Nishihama, Corina N. D’Alessandro-Gabazza, Hajime Fujimoto, Esteban C. Gabazza, Fumihiro Asano, Osamu Taguchi and Osamu Hataji
    Citation: Respiratory Research 2019 20:207
    Content type: Research Published on:

  6. Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe and w...

    Authors: Tuong N. Vu, Xuesong Chen, Hussein D. Foda, Gerald C. Smaldone and Nadia A. Hasaneen
    Citation: Respiratory Research 2019 20:206
    Content type: Research Published on:

  8. Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into Type 1 alveolar epithelial cells (AT1s). In the prese...

    Authors: Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Diana Feller, Veronika Csongei, Szilard Pal, Domokos Bartis, David R. Thickett and Judit Erzsebet Pongracz
    Citation: Respiratory Research 2019 20:204
    Content type: Research Published on:

  9. High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has nev...

    Authors: Zeina Akiki, Miora Andrianjafimasy, Farid Zerimech, Nicole Le Moual, Valérie Siroux, Orianne Dumas, Régis Matran and Rachel Nadif
    Citation: Respiratory Research 2019 20:203
    Content type: Letter to the Editor Published on:

  10. Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death in the world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate cancer pr...

    Authors: Shengjie Chen, Tianyi Gu, Ziwen Lu, Lipeng Qiu, Guoliang Xiao, Xiaozhong Zhu, Feng Li, Hui Yu, Gang Li and Hanqing Liu
    Citation: Respiratory Research 2019 20:202
    Content type: Research Published on:

  11. Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for CO...

    Authors: Xiaobo Liang, Xiang He, Yin Li, Junyi Wang, Dehong Wu, Xiefang Yuan, Xiaoyun Wang and Guoping Li
    Citation: Respiratory Research 2019 20:201
    Content type: Research Published on:

  12. Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronc...

    Authors: Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers and Estelle Cormet-Boyaka
    Citation: Respiratory Research 2019 20:200
    Content type: Letter to the Editor Published on:

  13. Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was develo...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Saher Burhan Shaker, Jesper Rømhild Davidsen, Janelle Yorke, Ole Hilberg and Elisabeth Bendstrup
    Citation: Respiratory Research 2019 20:199
    Content type: Research Published on:

  14. There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations ...

    Authors: Cecilia Mouronte-Roibás, Virginia Leiro-Fernández, Alberto Ruano-Raviña, Cristina Ramos-Hernández, Pedro Casado-Rey, Maribel Botana-Rial, Esmeralda García-Rodríguez and Alberto Fernández-Villar
    Citation: Respiratory Research 2019 20:198
    Content type: Research Published on:

  15. Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness i...

    Authors: David I. Kasahara, Jeremy E. Wilkinson, Youngji Cho, Aline P. Cardoso, Curtis Huttenhower and Stephanie A. Shore
    Citation: Respiratory Research 2019 20:197
    Content type: Research Published on:

  16. The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

    Authors: Guoqing Wang, Howard H. Lou, Jacqueline Salit, Philip L. Leopold, Sharon Driscoll, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas and Ronald G. Crystal
    Citation: Respiratory Research 2019 20:196
    Content type: Research Published on:

  17. Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

    Authors: Steven J. Pascoe, Alberto Papi, Dawn Midwinter, Sally Lettis and Neil Barnes
    Citation: Respiratory Research 2019 20:195
    Content type: Research Published on:

  18. The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

    Authors: Zhongwei Wen, Rongfang Jiang, Ying Huang, Zhineng Wen, Dong Rui, Xiaoxiao Liao and Zhougui Ling
    Citation: Respiratory Research 2019 20:194
    Content type: Research Published on:

  19. It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...

    Authors: Young-Jin Choi, Ju-Hee Jeon and Jae-Won Oh
    Citation: Respiratory Research 2019 20:193
    Content type: Research Published on:

  20. Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual an...

    Authors: Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin and Sheng-xing Zheng
    Citation: Respiratory Research 2019 20:192
    Content type: Research Published on:

  21. Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this...

    Authors: Maeva Zysman, Pierre-Régis Burgel, Isabelle Court-Fortune, Graziella Brinchault-Rabin, Pascale Nesme-Meyer, Pascale Surpas, Gaetan Deslée, Thierry Perez, Olivier Le Rouzic, Gilles Jebrak, Pascal Chanez, Jean-Louis Paillasseur, Denis Caillaud and Nicolas Roche
    Citation: Respiratory Research 2019 20:191
    Content type: Letter to the Editor Published on:

  22. Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response pl...

    Authors: Venkataramana K. Sidhaye, Janet T. Holbrook, Alyce Burke, Kuladeep R. Sudini, Sanjay Sethi, Gerard J. Criner, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Rajesh Thimmulappa, Robert A. Wise and Shyam Biswal
    Citation: Respiratory Research 2019 20:190
    Content type: Research Published on:

  23. The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be info...

    Authors: Nicolas Roche, Anestis Antoniadis, David Hess, Pei Zhi Li, Eric Kelkel, Sylvie Leroy, Christophe Pison, Pierre-Régis Burgel and Bernard Aguilaniu
    Citation: Respiratory Research 2019 20:189
    Content type: Research Published on:

  24. Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial d...

    Authors: Haili Sun, Fang Fang, Kun Li, Huina Zhang, Ming Zhang, Lichuan Zhang, Juan Li, Yanwen Qin and Yongxiang Wei
    Citation: Respiratory Research 2019 20:188
    Content type: Research Published on:

  25. Acute pulmonary embolism (APE) is one of the leading causes of death in cardiovascular disease. The 30-day mortality can still be 1.7–15% in non-high-risk APE patients. Some non-high-risk patients can progress...

    Authors: Dong Jia, Xue-lian Li, Qin Zhang, Gang Hou, Xiao-ming Zhou and Jian Kang
    Citation: Respiratory Research 2019 20:187
    Content type: Research Published on:

  26. An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...

    Authors: Stefan Andreas, Christian Röver, Judith Heinz, Sebastian Straube, Henrik Watz and Tim Friede
    Citation: Respiratory Research 2019 20:186
    Content type: Research Published on:

  27. We previously reported cryobiopsy (Cryo) with endobronchial ultrasonography-guide sheath (EBUS-GS) for peripheral pulmonary lesions (PPLs) provides significantly larger tissues than transbronchial biopsy (TBB)...

    Authors: Ken Arimura, Mitsuko Kondo, Yoji Nagashima, Masato Kanzaki, Fumi Kobayashi, Kiyoshi Takeyama, Jun Tamaoki and Etsuko Tagaya
    Citation: Respiratory Research 2019 20:185
    Content type: Research Published on:

  28. Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for seve...

    Authors: K. D. Hebert, N. Mclaughlin, Zhe Zhang, A. Cipriani, J. F. Alcorn and D. A. Pociask
    Citation: Respiratory Research 2019 20:184
    Content type: Research Published on:

  29. Asthma is a heterogeneous lung disease, usually characterised by chronic airway inflammation. Although evidence-based treatments are available in most countries, asthma control remains suboptimal, and asthma-r...

    Authors: Jaya Muneswarao, Mohamed Azmi Hassali, Baharudin Ibrahim, Bandana Saini, Irfhan Ali Hyder Ali and Ashutosh Kumar Verma
    Citation: Respiratory Research 2019 20:183
    Content type: Commentary Published on:

  30. Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study p...

    Authors: Spyros A. Papiris, Panagiotis Tsirigotis, Caroline Kannengiesser, Lykourgos Kolilekas, Konstantinos Gkirkas, Andriana I. Papaioannou, Patrick Revy, Paschalina Giouleka, Georgia Papadaki, Konstantinos Kagouridis, Vassiliki Pappa, Raphael Borie, Catherine Boileau, Demosthenes Bouros, Bruno Crestani and Effrosyni D. Manali
    Citation: Respiratory Research 2019 20:182
    Content type: Letter to the Editor Published on:

  31. KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

    Authors: Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat, Sarah L. O’Beirne, Robert J. Kaner, Jason G. Mezey, Haijun Zhang, Philip L. Leopold and Ronald G. Crystal
    Citation: Respiratory Research 2019 20:181
    Content type: Research Published on:

  32. CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmon...

    Authors: Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni and Marie Anna Nandeuil
    Citation: Respiratory Research 2019 20:180
    Content type: Research Published on:

  34. Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, ...

    Authors: Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller and Hui Cao
    Citation: Respiratory Research 2019 20:178
    Content type: Research Published on:

  35. Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesio...

    Authors: Kyu Min Lee, Geewon Lee, Ahreum Kim, Jeongha Mok, Ji Won Lee, Yeon Joo Jeong, Eun-Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee and Jung Seop Eom
    Citation: Respiratory Research 2019 20:177
    Content type: Research Published on:

  36. Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obs...

    Authors: Hiroto Takiguchi, Virginia Chen, Ma’en Obeidat, Zsuzsanna Hollander, J. Mark FitzGerald, Bruce M. McManus, Raymond T. Ng and Don D. Sin
    Citation: Respiratory Research 2019 20:176
    Content type: Research Published on:

  37. The amount of surfactant deposited in the lungs and its overall pulmonary distribution determine the therapeutic outcome of surfactant replacement therapy. Most of the currently available methods to determine ...

    Authors: Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Francesca Ricci, Francesca Boscaro, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Federico Bianco, Fabrizio Salomone, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp and Alan H. Jobe
    Citation: Respiratory Research 2019 20:175
    Content type: Research Published on:

  38. Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

    Authors: Xu Liu, Mei Mei, Xiang Chen, Yulan Lu, Xinran Dong, Liyuan Hu, Xiaojing Hu, Guoqiang Cheng, Yun Cao, Lin Yang and Wenhao Zhou
    Citation: Respiratory Research 2019 20:174
    Content type: Research Published on:

  39. Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

    Authors: David A. Leather, Louisa Yates, Henrik Svedsater, Loretta Jacques, Susan Collier, Danielle Powell and Rupert Jones
    Citation: Respiratory Research 2019 20:173
    Content type: Commentary Published on:

  40. Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

    Authors: Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall and Ian Sayers
    Citation: Respiratory Research 2019 20:172
    Content type: Research Published on:

  41. Metabolic adaptation in immune cells is necessary to modulate immune cell function as it is intricately coupled with intracellular metabolism. We aimed to characterize the metabolic state of human peripheral b...

    Authors: Amit R Agarwal, Smita Kadam, Ankita Brahme, Manas Agrawal, Komalkirti Apte, Govinda Narke, Kushal Kekan, Sapna Madas and Sundeep Salvi
    Citation: Respiratory Research 2019 20:171
    Content type: Research Published on:

  42. Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

    Authors: Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro and Mona Bafadhel
    Citation: Respiratory Research 2019 20:170
    Content type: Research Published on:

  43. We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

    Authors: Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey and Namhee Kwon
    Citation: Respiratory Research 2019 20:169
    Content type: Research Published on:

  44. Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosi...

    Authors: Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert Guzy, Gökhan M. Mutlu and Nickolai O. Dulin
    Citation: Respiratory Research 2019 20:168
    Content type: Research Published on:

  45. Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate...

    Authors: Edward M. Kerwin, Gary T. Ferguson, Mindy Mo, Kiernan DeAngelis and Paul Dorinsky
    Citation: Respiratory Research 2019 20:167
    Content type: Research Published on:

  46. Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in card...

    Authors: Yousef S. Aldabayan, Heidi A. Ridsdale, Ahmed M. Alrajeh, Abdulelah M. Aldhahir, Arthur Lemson, Jaber S. Alqahtani, Jeremy S. Brown and John R. Hurst
    Citation: Respiratory Research 2019 20:166
    Content type: Research Published on:

  47. Complement factor C5 can either aggravate or attenuate the T-helper type 2 (TH2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phas...

    Authors: Jack Yang, Ivan Ramirez Moral, Cornelis van ’t Veer, Alex F. de Vos, Regina de Beer, Joris J. T. H. Roelofs, B. Paul Morgan and Tom van der Poll
    Citation: Respiratory Research 2019 20:165
    Content type: Research Published on:

  48. Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about t...

    Authors: Yang Zhang, Yuanyuan Zeng, Ting Liu, Wenwen Du, Jianjie Zhu, Zeyi Liu and Jian-an Huang
    Citation: Respiratory Research 2019 20:164
    Content type: Research Published on:

  49. Pulmonary fibrosis is a progressive and irreversible disease for which therapeutic options are currently limited. A recent in vivo study showed that tenofovir, a nucleotide analogue reverse transcriptase inhib...

    Authors: Lingxia Li, Jing Zhao, Li Zhou, Jie Chen, Yuanyuan Ma, Yanyan Yu and Jun Cheng
    Citation: Respiratory Research 2019 20:163
    Content type: Research Published on:

  50. Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessari...

    Authors: Guanghui Liu, Catherine Betts, Danen M. Cunoosamy, Per M. Åberg, Jorrit J. Hornberg, Kinga Balogh Sivars and Taylor S. Cohen
    Citation: Respiratory Research 2019 20:162
    Content type: Review Published on:
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