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  1. Chronic obstructive pulmonary disease (COPD) is characterized by a progressive and abnormal inflammatory response in the lungs, mainly caused by cigarette smoking. Animal models exposed to cigarette smoke (CS)...

    Authors: Jef Serré, Ajime Tom Tanjeko, Carolien Mathyssen, An-Sofie Vanherwegen, Tobias Heigl, Rob Janssen, Eric Verbeken, Karen Maes, Bart Vanaudenaerde, Wim Janssens and Ghislaine Gayan-Ramirez
    Citation: Respiratory Research 2021 22:86
    Content type: Research Published on:

  2. Tbx2 encodes a transcriptional repressor implicated in the development of numerous organs in mouse. During lung development TBX2 maintains the proliferation of mesenchymal progenitors, and hence, epithelial proli...

    Authors: Timo H. Lüdtke, Irina Wojahn, Marc-Jens Kleppa, Jasper Schierstaedt, Vincent M. Christoffels, Patrick Künzler and Andreas Kispert
    Citation: Respiratory Research 2021 22:85
    Content type: Research Published on:

  3. In the INBUILD trial in patients with chronic fibrosing interstitial lung diseases (ILDs) and a progressive phenotype, nintedanib reduced the rate of ILD progression with adverse events that were manageable fo...

    Authors: Vincent Cottin, Luca Richeldi, Ivan Rosas, Maria Otaola, Jin Woo Song, Sara Tomassetti, Marlies Wijsenbeek, Manuela Schmitz, Carl Coeck, Susanne Stowasser, Rozsa Schlenker-Herceg and Martin Kolb
    Citation: Respiratory Research 2021 22:84
    Content type: Research Published on:

  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Christophe Pison, Pallav L. Shah, Dirk‑Jan Slebos, Vincent Ninane, Wim Janssens, Thierry Perez, Romain Kessler, Gaetan Deslee, Justin L. Garner, Jorine E. Hartman, Bruno Degano, Anna Mayr, Martin Mayse, Alexander D. Peterson and Arschang Valipour
    Citation: Respiratory Research 2021 22:83
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2021 22:62

  5. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Solmaz Ehteshami‑Afshar, Kristina Crothers, Benjamin Rodwin, Brett Bade, Cynthia Brandt and Kathleen M. Akgün
    Citation: Respiratory Research 2021 22:82
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2021 22:50

  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jordan Smoothy, Alexander N. Larcombe, Emily K. Chivers, Vance B. Matthews and Shelley Gorman
    Citation: Respiratory Research 2021 22:81
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2019 20:21

  7. Short-term exposure to ozone and nitrogen dioxide is a risk factor for acute exacerbation (AE) of idiopathic pulmonary fibrosis (AE-IPF). The comprehensive roles of exposure to fine particulate matter in AE-IP...

    Authors: Masahiro Tahara, Yoshihisa Fujino, Kei Yamasaki, Keishi Oda, Takashi Kido, Noriho Sakamoto, Toshinori Kawanami, Kensuke Kataoka, Ryoko Egashira, Mikiko Hashisako, Yuzo Suzuki, Tomoyuki Fujisawa, Hiroshi Mukae, Takafumi Suda and Kazuhiro Yatera
    Citation: Respiratory Research 2021 22:80
    Content type: Research Published on:

  8. Pulmonary rehabilitation (PR) improves exercise capacity, health-related quality of life (HRQoL) and dyspnea in chronic obstructive pulmonary disease (COPD) patients. Maintenance programs can sustain the benef...

    Authors: Léo Blervaque, Christian Préfaut, Hélène Forthin, Francis Maffre, Marion Bourrelier, Nelly Héraud, Matthias Catteau, Pascal Pomiès, Dany Jaffuel, Nicolas Molinari, Maurice Hayot and Fares Gouzi
    Citation: Respiratory Research 2021 22:79
    Content type: Research Published on:

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose…
    Citation: Respiratory Research 2021 22:78
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2021 22:63

  10. Studies report high in-hospital mortality of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) especially for those requiring admission to an intensive care unit. Recognizing factors associa...

    Authors: Yang Cao, Zhenzhen Xing, Huanyu Long, Yilin Huang, Ping Zeng, Jean-Paul Janssens and Yanfei Guo
    Citation: Respiratory Research 2021 22:77
    Content type: Research Published on:

  11. Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T ...

    Authors: Alberto Ricci, Alessandra Pagliuca, Michela D’Ascanio, Marta Innammorato, Claudia De Vitis, Rita Mancini, Simonetta Giovagnoli, Francesco Facchiano, Bruno Sposato, Paolo Anibaldi, Adriano Marcolongo, Chiara De Dominicis, Andrea Laghi, Emanuele Muscogiuri and Salvatore Sciacchitano
    Citation: Respiratory Research 2021 22:76
    Content type: Research Published on:

  12. Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced incre...

    Authors: Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight, Delbert R. Dorscheid, Tillie L. Hackett, Michael R. Hughes, Kelly M. McNagny, Jeremy A. Hirota, Masahiro Niikura, S. F. Paul Man and Don D. Sin
    Citation: Respiratory Research 2021 22:75
    Content type: Research Published on:

  13. The pathophysiology of chronic obstructive pulmonary disease (COPD) relies on airway remodelling and inflammation. Alterations of mucociliary clearance are a major hallmark of COPD caused by structural and fun...

    Authors: Jeanne-Marie Perotin, Myriam Polette, Gaëtan Deslée and Valérian Dormoy
    Citation: Respiratory Research 2021 22:74
    Content type: Letter to the Editor Published on:

  14. The mechanism for spread of SARS-CoV-2 has been attributed to large particles produced by coughing and sneezing. There is controversy whether smaller airborne particles may transport SARS-CoV-2. Smaller partic...

    Authors: Rebecca A. Stern, Petros Koutrakis, Marco A. G. Martins, Bernardo Lemos, Scot E. Dowd, Elsie M. Sunderland and Eric Garshick
    Citation: Respiratory Research 2021 22:73
    Content type: Research Published on:

  15. Chlamydia pneumoniae and Mycoplasma pneumoniae have been implicated in the pathogenesis of asthma and are responsible for chronic inflammation when host immune system fails to eradicate the bacteria.

    Authors: Doriane Calmes, Pascale Huynen, Virginie Paulus, Monique Henket, Françoise Guissard, Catherine Moermans, Renaud Louis and Florence Schleich
    Citation: Respiratory Research 2021 22:72
    Content type: Research Published on:

  16. Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) represents one of the most challenging scenarios for aerosol medicine. This challenge is highlighted by the undersized anato...

    Authors: Federico Bianco, Fabrizio Salomone, Ilaria Milesi, Xabier Murgia, Sauro Bonelli, Elena Pasini, Raffaele Dellacà, Maria Luisa Ventura and Jane Pillow
    Citation: Respiratory Research 2021 22:71
    Content type: Review Published on:

  17. Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored.

    Authors: Tianshi David Wu, Ashraf Fawzy, Gregory L. Kinney, Jessica Bon, Maniraj Neupane, Vickram Tejwani, Nadia N. Hansel, Robert A. Wise, Nirupama Putcha and Meredith C. McCormack
    Citation: Respiratory Research 2021 22:70
    Content type: Research Published on:

  18. CD34, a pan-selectin binding protein when glycosylated, has been shown to be involved in leukocyte migration to the site of inflammation. However, only one report is available on the expression and role of CD3...

    Authors: Gurpreet K. Aulakh, Sushmita Maltare and Baljit Singh
    Citation: Respiratory Research 2021 22:69
    Content type: Research Published on:

  19. Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reli...

    Authors: Liang-Yuan Li, Tian-Sheng Yan, Jing Yang, Yu-Qi Li, Lin-Xi Fu, Lan Lan, Bin-Miao Liang, Mao-Yun Wang and Feng-Ming Luo
    Citation: Respiratory Research 2021 22:68
    Content type: Research Published on:

  20. Infection with Haemophilus influenzae (Hi) or Moraxella catarrhalis (Mcat) is a risk factor for exacerbation in chronic obstructive pulmonary disease (COPD). The ability to predict Hi- or Mcat-associated exacerba...

    Authors: Lucio Malvisi, Laura Taddei, Aparna Yarraguntla, Tom M. A. Wilkinson and Ashwani Kumar Arora
    Citation: Respiratory Research 2021 22:67
    Content type: Research Published on:

  21. FIBRONET was an observational, multicentre, prospective cohort study investigating the baseline characteristics, clinical course of disease and use of antifibrotic treatment in Italian patients with idiopathic...

    Authors: V. Poletti, C. Vancheri, C. Albera, S. Harari, A. Pesci, R. R. Metella, B. Campolo, G. Crespi and S. Rizzoli
    Citation: Respiratory Research 2021 22:66
    Content type: Research Published on:

  22. Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased effica...

    Authors: Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin and Delbert R. Dorscheid
    Citation: Respiratory Research 2021 22:65
    Content type: Research Published on:

  23. Beta-blockers are associated with reduced mortality in patients with cardiovascular disease but are often under prescribed in those with concomitant COPD, due to concerns regarding respiratory side-effects. We...

    Authors: Claudia Gulea, Rosita Zakeri, Vanessa Alderman, Alexander Morgan, Jack Ross and Jennifer K. Quint
    Citation: Respiratory Research 2021 22:64
    Content type: Review Published on:

  24. The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of asthma. However, the role of mitochondr...

    Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose…
    Citation: Respiratory Research 2021 22:63
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:78

  25. Targeted lung denervation (TLD) is a novel bronchoscopic therapy that disrupts parasympathetic pulmonary nerve input to the lung reducing clinical consequences of cholinergic hyperactivity. The AIRFLOW-1 study...

    Authors: Christophe Pison, Pallav L. Shah, Dirk-Jan Slebos, Vincent Ninane, Wim Janssens, Thierry Perez, Romain Kessler, Gaetan Deslee, Justin L. Garner, Jorine E. Hartman, Bruno Degano, Anna Mayr, Martin Mayse, Alexander D. Peterson and Arschang Valipour
    Citation: Respiratory Research 2021 22:62
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:83

  27. Rapid response system (RRS) is being increasingly adopted to improve patient safety in hospitals worldwide. However, predictors of survival outcome after RRS activation because of unexpected clinical deteriora...

    Authors: Jimyung Park, Yeon Joo Lee, Sang-Bum Hong, Kyeongman Jeon, Jae Young Moon, Jung Soo Kim, Byung Ju Kang, Jong-Joon Ahn, Dong-Hyun Lee, Jisoo Park, Jae Hwa Cho and Sang-Min Lee
    Citation: Respiratory Research 2021 22:60
    Content type: Research Published on:

  28. Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.

    Authors: Wenjia Chen, Mohsen Sadatsafavi, J. Mark FitzGerald, Larry D. Lynd and Don D. Sin
    Citation: Respiratory Research 2021 22:59
    Content type: Research Published on:

  29. An adverse role for obstructive sleep apnea (OSA) in cancer aggressiveness and mortality has recently emerged from clinical and animal studies, and the reasons have not been fully determined. Cancer stem cells...

    Authors: Shengyu Hao, Xiaodan Zhu, Zilong Liu, Xiaodan Wu, Shanqun Li, Pan Jiang and Liyan Jiang
    Citation: Respiratory Research 2021 22:58
    Content type: Research Published on:

  30. MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants w...

    Authors: Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan and Charitharth Vivek Lal
    Citation: Respiratory Research 2021 22:57
    Content type: Research Published on:

  31. Chronic obstructive pulmonary disease (COPD) has been proposed as a disease of accelerated aging. Several cross-sectional studies have related a shorter telomere length (TL), a marker of biological aging, with...

    Authors: E. Córdoba-Lanús, S. Cazorla-Rivero, M. A. García-Bello, D. Mayato, F. Gonzalvo, J. Ayra-Plasencia, B. Celli and C. Casanova
    Citation: Respiratory Research 2021 22:56
    Content type: Research Published on:

  32. Which patients should receive dual therapy as initial treatment for chronic obstructive pulmonary disease (COPD) is only loosely defined. We evaluated if a lower forced expiratory volume in 1 s (FEV1) identifies ...

    Authors: Jieun Kang, Jae Seung Lee, Sei Won Lee, Jung Bok Lee and Yeon-Mok Oh
    Citation: Respiratory Research 2021 22:55
    Content type: Research Published on:

  33. Inhaled corticosteroid (ICS) therapy for COPD should be guided by exacerbations and blood-eosinophils according to the GOLD 2020 strategy document. In the present study, we applied these recent recommendations...

    Authors: Osman Savran, Nina Godtfredsen, Torben Sørensen, Christian Jensen and Charlotte Suppli Ulrik
    Citation: Respiratory Research 2021 22:54
    Content type: Research Published on:

  34. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. Several risk factors such as smoking, air pollution, inhaled toxins, high body mass index and infectious agents are involved in the pa...

    Authors: Shayan Mostafaei, Babak Sayad, Maryam Ebadi Fard Azar, Mohammad Doroudian, Shima Hadifar, Ava Behrouzi, Parisa Riahi, Bashdar Mahmud Hussen, Bahareh Bayat, Javid Sadri Nahand and Mohsen Moghoofei
    Citation: Respiratory Research 2021 22:53
    Content type: Review Published on:

  35. Chinese Yunnan Province, located in the Yunnan–Guizhou Plateau, is a famous tourist paradise where acute high-altitude illness common occurs among lowland people visitors due to non-acclimatization to the acut...

    Authors: Xing Fu, Chunyan Yang, Bing Chen, Kexing Zeng, Siyuan Chen and Yi Fu
    Citation: Respiratory Research 2021 22:52
    Content type: Research Published on:

  36. Little is known on the role of transient receptor potential ankyrin 1 (TRPA1) in fibroblast—myofibroblast transition (FMT) that can lead to airway remodeling which is a major problem for severe asthma and fibr...

    Authors: Jennifer Maries Go Yap, Takashi Ueda, Yoshihiro Kanemitsu, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Testsuya Oguri, Shinya Ugawa and Akio Niimi
    Citation: Respiratory Research 2021 22:51
    Content type: Research Published on:

  37. The importance of vaccinations for COPD patients has been previously described. However, there is still a gap between guideline recommendations and the implementation of preventive care delivery for these pati...

    Authors: Solmaz Ehteshami-Afshar, Kristina Crothers, Benjamin Rodwin, Brett Bade, Cynthia Brandt and Kathleen M. Akgün
    Citation: Respiratory Research 2021 22:50
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in Respiratory Research 2021 22:82

  38. Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndr...

    Authors: Karina Cuevas-Mora, Willy Roque, Hoora Shaghaghi, Bernadette R. Gochuico, Ivan O. Rosas, Ross Summer and Freddy Romero
    Citation: Respiratory Research 2021 22:49
    Content type: Research Published on:

  39. Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to as...

    Authors: Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens and Loes E. M. Kistemaker
    Citation: Respiratory Research 2021 22:48
    Content type: Research Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock and Kian Fan Chung
    Citation: Respiratory Research 2021 22:47
    Content type: Correction Published on:

    The original article was published in Respiratory Research 2021 22:10

  41. Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathoge...

    Authors: Yaping Wang, Kou Liao, Bo Liu, Chao Niu, Wenjing Zou, Lili Yang, Ting Wang, Daiyin Tian, Zhengxiu Luo, Jihong Dai, Qubei Li, Enmei Liu, Caihui Gong, Zhou Fu, Ying Li and Fengxia Ding
    Citation: Respiratory Research 2021 22:46
    Content type: Research Published on:

  42. S100 calcium binding protein A9 (S100A9) is a pro-inflammatory alarmin associated with several inflammation-related diseases. However, the role of S100A9 in lung injury in sepsis has not been fully investigate...

    Authors: Boying Zhao, Renfu Lu, Jianjun Chen, Ming Xie, Xingji Zhao and Lingwen Kong
    Citation: Respiratory Research 2021 22:45
    Content type: Research Published on:

  43. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung diseases with a poor prognosis. Long non-coding RNAs (lncRNAs) have been reported to be involved in IPF in several studies. However, the...

    Authors: Panpan Liu, Lei Zhao, Yuxia Gu, Meilan Zhang, Hongchang Gao and Yingxia Meng
    Citation: Respiratory Research 2021 22:44
    Content type: Research Published on:

  44. The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) is heterogenous depending on the characterized sources of inflammation. This study aimed to evaluate COPD phenotypes a...

    Authors: Junghyun Kim, Bom Kim, So Hyeon Bak, Yeon-Mok Oh and Woo Jin Kim
    Citation: Respiratory Research 2021 22:43
    Content type: Research Published on:

  45. Alveolar epithelial cells play an essential role in the initiation and progression of pulmonary fibrosis, and the occurrence of epithelial–mesenchymal transition (EMT) may be the early events of pulmonary fibr...

    Authors: Zhenzhen Ma, Chunyan Ma, Qingfeng Zhang, Yang Bai, Kun Mu, Xiangyuan Liu and Qingrui Yang
    Citation: Respiratory Research 2021 22:42
    Content type: Research Published on:

  46. Childhood asthma and allergic diseases are a significant global problem. There are inconsistent findings on the associations of delivery mode, the number of children in the household and breastfeeding with chi...

    Authors: Yabin Hu, Yiting Chen, Shijian Liu, Fan Jiang, Meiqin Wu, Chonghuai Yan, Jianguo Tan, Guangjun Yu, Yi Hu, Yong Yin, Jiajie Qu, Shenghui Li and Shilu Tong
    Citation: Respiratory Research 2021 22:41
    Content type: Research Published on:

  47. Observational data under real-life conditions in idiopathic pulmonary fibrosis (IPF) is scarce. We explored anti-fibrotic treatment, disease severity and phenotypes in patients with IPF from the Swedish IPF Re...

    Authors: Jing Gao, Dimitrios Kalafatis, Lisa Carlson, Ida H. A. Pesonen, Chuan-Xing Li, Åsa Wheelock, Jesper M. Magnusson and C. Magnus Sköld
    Citation: Respiratory Research 2021 22:40
    Content type: Research Published on:

  49. Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 i...

    Authors: D. J. Leeming, F. Genovese, J. M. B. Sand, D. G. K. Rasmussen, C. Christiansen, G. Jenkins, T. M. Maher, J. Vestbo and M. A. Karsdal
    Citation: Respiratory Research 2021 22:38
    Content type: Commentary Published on:

  50. Comorbidities play a key role in severe disease outcomes in COVID-19 patients. However, the literature on preexisting respiratory diseases and COVID-19, accounting for other possible confounders, is limited. T...

    Authors: Prateek Lohia, Kalyan Sreeram, Paul Nguyen, Anita Choudhary, Suman Khicher, Hossein Yarandi, Shweta Kapur and M. Safwan Badr
    Citation: Respiratory Research 2021 22:37
    Content type: Research Published on:
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