Hickey KA, Rubani GB, Paul RJ, Highsmith RF: Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol. 1985, 248: C550-C556.
PubMed
Google Scholar
Gillespie MN, Owasoyo JO, McMurtry IF, O'Brien RF: Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther. 1986, 236: 339-343.
PubMed
Google Scholar
O'Brien RF, Robbing RJ, McMurtry IF: Endothelial cells in culture produce a vasoconstrictor substance. J Cell Physiol. 1987, 132: 263-270.
PubMed
Google Scholar
Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1999, 332: 411-415.
Google Scholar
Arinami T, Ishikawa M, Inoue A, Yanagisawa M, Masaki T, Yoshida MC, Hamaguchi H: Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN-1) to 6p23-p24, the endothelin-2 gene (EDN-2) to 1p34, and the endothelin-3 gene (EDN-3) to 20q13.2-q13.3. Am J Hum Genet. 1991, 48: 990-996.
PubMed
PubMed Central
Google Scholar
Inoue A, Yanagisawa M, Takuwa Y, Mitsui Y, Kobayashi M, Masaki T: The human preproendothelin-1 gene: complete nucleotide sequence and regulation of expression. J Biol Chem. 1989, 264: 14954-14959.
PubMed
Google Scholar
Kimura S, Kasuya Y, Sawamura T, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Conversion of bug endothelin-1 to 21-residue endothelin-1 is necessary for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1. J Cardiovasc Pharmacol. 1989, 13 (suppl 5): S5-S7.
Google Scholar
Battistini B, Dussault P: Biosynthesis, distribution and metabolism of endothelins in the pulmonary system. Pulmon Pharmacol Ther. 1998, 11: 79-88.
Google Scholar
Nakamura S, Naruse M, Naruse K, Demura H, Uemura H: Immunocytochemical localization of endothelin in cultured bovine endothelial cells. Histochemistry. 1990, 94: 475-477.
PubMed
Google Scholar
Harrison VJ, Barnes K, Turner AJ, Wood E, Corder R, Vane JR: Identification of endothelin-1 and big endothelin-1 in secretory vesicles isolated from bovine aortic endothelial cells. Proc Natl Acad Sci USA. 1995, 92: 6344-6348.
PubMed
PubMed Central
Google Scholar
Harrison VJ, Corder R, Anggard EE, Vane JR: Evidence for vesicles that transport endothelin-1 in bovine aortic endothelial cells. J Cardiovasc Pharmacol. 1993, 22 (suppl 2): S57-S60.
Google Scholar
Wagner OF, Christ G, Wojta J, Vierhapper H, Parzer S, Nowotny PJ, Schneider B, Waldhausl W, Binder BR: Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem. 1992, 267: 16066-16068.
PubMed
Google Scholar
Noguchi Y, Uchida Y, Endo T, Ninomiya H, Nomura A, Sakamoto T, Goto Y, Haraoka S, Shimokama T, Watanabe T, Hasegawa S: The induction of cell differentiation and polarity of tracheal epithelium cultured on amniotic membrane. Biochem Biophys Res Commun. 1995, 210: 302-309. 10.1006/bbrc.1995.1661.
PubMed
Google Scholar
Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T: Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature. 1990, 348: 732-735.
PubMed
Google Scholar
Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S: Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990, 348: 730-732.
PubMed
Google Scholar
Lippton HL, Hauth TA, Cohen GA, Hyman AL: Functional evidence for different endothelin receptors in the lung. J Appl Physiol. 1993, 75: 38-48.
PubMed
Google Scholar
Dupuis J, Stewart DJ, Cernacek P, Gosselin G: Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation. 1996, 94: 1578-1584.
PubMed
Google Scholar
Michael JR, Markewitz BA: Endothelins and the lung. Am J Respir Crit Care Med. 1996, 154: 555-581.
PubMed
Google Scholar
Iwasaki S, Homma T, Matsuda Y, Kon V: Endothelin receptor subtype B mediates auto-induction of endothelin-1 in rat mesangial cells. J Biol Chem. 1995, 270: 6997-7003.
PubMed
Google Scholar
Kourembanas S, McQuillan LP, Leung GK, Faller DV: Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest. 1993, 92: 99-104.
PubMed
PubMed Central
Google Scholar
Rozengurt N, Springall DR, Polak JM: Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice. J Pathol. 1990, 160: 5-8.
PubMed
Google Scholar
Power RF, Wharton J, Zhao Y, Bloom SR, Polak JM: Autoradiographic localization of endothelin-1 binding sites in the cardiovascular and respiratory system. J Cardiovasc Pharmacol. 1989, 13 (suppl 5): S50-S56.
Google Scholar
Henry PT: Endothelin receptor distribution and function in the airways. Clin Exp Pharmacol Physiol. 1999, 26: 162-167. 10.1046/j.1440-1681.1999.03010.x.
PubMed
Google Scholar
Finsnes F, Skjonsberg SK, Lyberg T, Christensen G: Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation. Eur Respir J. 2000, 15: 743-750. 10.1183/09031936.00.15474300.
PubMed
Google Scholar
Satoh M, Shimura S, Ishihara H, Nagaki M, Sasaki H, Takishima T: Endothein-1 stimulates chloride secretion across canine tracheal epithelium. Respiration. 1992, 59: 145-150.
PubMed
Google Scholar
Tamaoki J, Kanemura T, Sakai N, Isono K, Kobayashi K, Takizawa T: Endothelin stimulates cililary beat frequency and chloride secretion in canine cultured tracheal epithelium. Am J Respir Cell Mol Biol. 1991, 4: 426-431.
PubMed
Google Scholar
Murlas CG, Gulati A, Singh G, Najmabadi F: Endothelin-1 stimulates proliferation of normal airway epithelial cells. Biochem Biophys Res Commun. 1995, 212: 953-959. 10.1006/bbrc.1995.2062.
PubMed
Google Scholar
Glassberg MK, Ergul A, Wanner A, Puett D: Endothelin-1 promotes mitogenesis in airway smooth muscle cells. Am J Respir Cell Mol Biol. 1994, 10: 316-321.
PubMed
Google Scholar
Candenas M-L, Naline E, Sarria B, Advenier C: Effect of epithelium removal and enkephalin inhibition of the bronchoconstrictor response of three endothelins and the human isolated bronchus. Eur J Pharmacol. 1992, 210: 291-297.
PubMed
Google Scholar
Hay DWP, Luttmann MA, Hubbard WC, Undem BJ: Endothelin receptor subtypes in human and guinea pig pulmonary tissues. Br J Pharmacol. 1993, 110: 1175-1183.
PubMed
PubMed Central
Google Scholar
Goldie RG, Heny PJ, Knott PG, Self GJ, Luttmann MA, Hay DWP: Endothelin-1 receptor density, distribution and function in human isolated asthmatic airway. Am J Respir Crit Care Med. 1995, 152: 1653-1658.
PubMed
Google Scholar
Hay DWP, Hubbard WC, Undem BJ: Endothelin-induced contraction and mediator release in human bronchus. Br J Pharmacol. 1993, 110: 392-398.
PubMed
PubMed Central
Google Scholar
Blade PN, Ghabei GH, Takahashi K, Bertheton-Watt D, Kransz T, Pollen CT, Bloom SR: Formation of endothelin by cultured airway epithelial cells. FEBS Lett. 1989, 255: 129-132.
Google Scholar
Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985, 131: 599-606.
PubMed
Google Scholar
Noguchi K, Ishikawa K, Yano M, Ahmed A, Cortes A, Abraham WM: Endothelin-1 contributes to antigen-induced airways hyperresponsiveness. J Appl Physiol. 1995, 79: 700-705.
PubMed
Google Scholar
Nagase T, Kurihara H, Kurihara Y, Aoki-Nagase T, Nagai R, Ouchi Y: Disruption of ET-1 gene enhances pulmonary responses to methacholine via a functional mechanism in knockout mice. J Appl Physiol. 1999, 87: 2020-2024.
PubMed
Google Scholar
Nagase T, Kurihara H, Kurihara Y, Aoki T, Fukuchi Y, Yazaki Y, Ouchi Y: Airway hyperresponsiveness in mutant mice deficient in endothelin-1. Am J Respir Crit Care Med. 1998, 157: 560-564.
PubMed
Google Scholar
Chalmers GW, Little SA, Patel KR, Thomson NC: Endothelin-1-induced bronchoconstriction in asthma. Am J Respir Crit Care Med. 1997, 156: 382-388.
PubMed
Google Scholar
Finsnes F, Skjonsberg OH, Tonnessen T, Naess O, Lyberg T, Christensen G: Endothelin production and effects of endothelin antagonism during experimental airway inflammation. Am J Respir Crit Care Med. 1997, 155: 1404-1412.
PubMed
Google Scholar
Chalmers GW, MacLeod KJ, Thomson LJ, Little SA, Patel KR, McSharry C, Thomson NC: Sputum cellular responses to inhaled endothelin-1 in asthma. Clin Exp Allergy. 1999, 29: 1526-1531. 10.1046/j.1365-2222.1999.00496.x.
PubMed
Google Scholar
Sirois MG, Filep JG, Rousseau A, Farmer A, Plante GE, Sirois P: Endothelin-1 enhances vascular permeability in conscious rats: role of thromboxane A2. Eur J Pharmacol. 1992, 214: 119-125.
PubMed
Google Scholar
Goldie RG: Potential role of the endothelins in airway remodeling in asthma. Pulmon Pharmacol Ther. 1999, 12: 79-80.
Google Scholar
Sun G, Stacey MA, Bellini A, Marini M, Mattoli S: Endothelin-1 induces bronchial myofibroblast differentiation. Peptides. 1997, 18: 1449-1451. 10.1016/S0196-9781(97)00194-0.
PubMed
Google Scholar
Finsnes F, Christensen G, Lyberg T, Sejersted OM, Skjonsberg OH: Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation. Am J Respir Crit Care Med. 1998, 158: 1600-1606.
PubMed
Google Scholar
Vittori E, Marini M, Fasoli A, DeFranchis R, Mattoli S: Increased expression of endothelin in bronchial epithelial cells of asthamtic patients and effect of corticosteroids. Am Rev Respir Dis. 1992, 146: 1320-1325.
PubMed
Google Scholar
Ackerman V, Carpi V, Bellini A, Vassalli G, Marini M, Mattoli S: Constitutive expression of endothelin in bronchial and epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by histamine and interleukin-1. J Allergy Clin Immunol. 1995, 96: 618-627.
PubMed
Google Scholar
Fujitani Y, Trifileff A, Tsuyuki S, Coyle AJ, Bertrand C: Endothelin receptor antagonists inhibit antigen induced lung inflammation in mice. Am J Respir Crit Care Med. 1997, 155: 1890-1894.
PubMed
Google Scholar
Chen W-Y, Yu J, Wang J-Y: Decreased production of endothlin-1 in asthmatic children after immunotherapy. J Asthma. 1995, 32: 29-35.
PubMed
Google Scholar
Aoki T, Kojima T, Ono A, Unishi G, Yoshijima S, Kameda-Hayashi N, Yamamoto C, Hirata Y, Kobayashi Y: Circulating endothelin-1 levels in patients with bronchial asthma. Ann Allergy. 1994, 73: 365-369.
PubMed
Google Scholar
Sofia M, Mormile M, Faraone S, Alifano M, Zofra S, Romano L, Carratu V: Increased endothelin-like immunoreactive material on bronchoalveolar lavage fluid from patients with bronchial asthma and patients with interstitial lung disease. Respiration. 1993, 60: 89-95.
PubMed
Google Scholar
Redington AE, Springall DR, Ghatei MA, Lau LCK, Bloom SR, Holgate ST, Polak JM, Howarth PH: Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am J Respir Crit Care Med. 1995, 151: 1034-1039.
PubMed
Google Scholar
Mattoli S, Soloperto M, Marini M, Fasoli A: Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J Allergy Clin Immunol. 1991, 88: 376-384.
PubMed
Google Scholar
Moller S, Uddman R, Granstrom B, Edvinsson L: Altered ration of ETa and ETb receptor mRNA in bronchial biopsies from patients with asthma and chronic airway obstruction. Eur J Pharmacol. 1996, 365: R1-R3.
Google Scholar
Kraft M, Beam WR, Wenzel SE, Zamora MR, O'Brien RF, Martin RJ: Blood and bronchoalveolar lavage endothelin-1 levels in nocturnal asthma. Am J Respir Crit Care Med. 1994, 149: 947-952.
Google Scholar
Aoki T, Kojima T, Ono A, Unishi G, Yoshijima S, Kameda-Hayashi N, Yamamoto C, Hirata Y, Kobayashi Y: Circulating endothelin-1 levels in patients with bronchial asthma. Ann Allergy. 1994, 73: 365-369.
PubMed
Google Scholar
Springall DR, Howarth PH, Counihan H, Djukanovic R, Holgate ST, Polak JM: Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet. 1991, 337: 697-701.
PubMed
Google Scholar
Haak T, Jungman E, Raab C, Usadel KH: Elevated endothelin-1 levels after cigarette smoking. Metabolism. 1994, 43: 267-269.
PubMed
Google Scholar
Fujii T, Otsuka T, Tanaka S, Kanazawa Y, Hirata K, Kohno M, Kurihara N, Yoshikawa J: Plasma endothelin-1 levels in chronic obstructive pulmonary disease: relationship with naturitic peptide. Respiration. 1999, 66: 212-219.
PubMed
Google Scholar
Chalmers GW, Macleod KJ, Sriram S, Thomson LJ, McSharry C, Stack BHR, Thomson NC: Sputum endothelin-1 is increased in active fibrosis and chronic obstructive pulmonary disease. Eur Respir J. 1999, 13: 1288-1292. 10.1034/j.1399-3003.1999.13f12.x.
PubMed
Google Scholar
Celik G, Karabiyikoglu G: Local and peripheral plasma endothelin-1 in pulmonary hypertension secondary to chronic obstructive pulmonary disease. Respiration. 1998, 65: 289-294.
PubMed
Google Scholar
Sofia M, Mormile M, Faraone S, Carratu P, Alifano M, Di Benedetto G, Carruth L: Increased 24 hour endothelin-1 urinary excretion in patients with chronic obstructive pulmonary disease. Respiration. 1994, 61: 263-268.
PubMed
Google Scholar
Ong AC, Jowett TP, Firth JD, Burton S, Karet FE, Fine LG: An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int. 1995, 48: 390-401.
PubMed
Google Scholar
Kiowski W, Linder L, Stoschitzky K, Pfisterer M, Burckhardt D, Burkart F, Buhler : Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers. Circulation. 1994, 90: 27-34.
PubMed
Google Scholar
Cases E, Vila JM, Medina P, Aldasoro M, Segarra G, Lluch S: Increased responsiveness of human pulmonary arteries in patients with positive bronchodilator responses. Br J Pharmacol. 1996, 119: 1337-1340.
PubMed
PubMed Central
Google Scholar
Helset E, Lindal S, Olsen R, Myklebust R, Jorgensen L: Endothelin-1 causes sequential trapping of platelets and neutrophils in pulmonary microcirculation in rats. Am J Physiol. 1996, 271: L538-L546.
PubMed
Google Scholar
Halim A, Kanayama N, El Maradny E, Maehara K, Mashiko H, Terao T: Activated neutrophils by endothelin-1 caused tissue damage in human umbilical cord. Thromb Res. 1995, 77: 321-327.
PubMed
Google Scholar
Ishida K, Takeshige K, Minakami S: Endothelin-1 enhances superoxide generation of human neutrophils stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenalanine. Biochem Biophys Res Commun. 1990, 173: 496-500.
PubMed
Google Scholar
Gomez-Garre D, Guerra M, Gonzalez E, Lopez-Farre A, Riesco A, Caramelo C, Escanero F, Egido J: Aggregation of human polymorphonuclear leukocytes by endothelium: role of platelet activating factor. Eur J Pharmacol. 1992, 224: 167-172.
PubMed
Google Scholar
Helset E, Ytrehus K, Tveita T, Kjaeve J, Jorgensen L: Endothelin-1 causes accumulation of leukocytes in the pulmonary circulation. Circ Shock. 1994, 44: 201-209.
PubMed
Google Scholar
Zheng L, Tipoe G, Lam W-K, Ho JCM, Shum I, Ooi GC, Leung R, Tsang KWT: Endothelin-1 in stable bronchiectasis. Eur Respir J. 2000, 16: 146-149. 10.1034/j.1399-3003.2000.16a26.x.
PubMed
Google Scholar
Paradis I, Yousem S, Griffith B: Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin Chest Med. 1993, 14: 751-763.
PubMed
Google Scholar
Schersten H, Hedner T, McGregor CGA, Miller VM, Martensson G, Riise GC, FN Nilsson: Increased levels of endothelin-1 in bronchoalveolar lavage fluid in patients with lung allografts. J Thorac Cardiovasc Surg. 1996, 111: 253-258.
PubMed
Google Scholar
Aarnio P, Tukiainen P, Taskinen E, Harjula A, Fyhrquist F: Endothelin in bronchoalveolar lavage fluid is increased in lung transplant patients. Scand J Thorac Cardiovasc Surg. 1996, 30: 113-116.
PubMed
Google Scholar
Takeda S, Sawa Y, Minami M, Kaneda Y, Fujii Y, Shirakura R, M Yanagisawa, Matsuda H: Experimental bronchiolitis obliterans induced by HVJ-liposome mediated endothelin-1 gene transfer. Ann Thorac Surg. 1997, 63: 1562-1567.
PubMed
Google Scholar
Yoshizumi M, Kurihara H, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Yazaki Y: Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells. Biochem Biophys Res Commun. 1989, 161: 859-864.
PubMed
Google Scholar
Prins BA, Hu R-M, Nazario B, Pedran A, Frank HJL, Weber MA, Levin ER: Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells. J Biol Chem. 1994, 269: 11938-11944.
PubMed
Google Scholar
Markewitz BA, Kohan DE, Michael DR: Hypoxia decreased endothelin-1 synthesis by rat lung endothelial cells. Am J Physiol. 1995, 269: L215-L220.
PubMed
Google Scholar
Michael JR, Markewitz BA, Kohan DE: Oxidant stress regulates basal endothelin production by cultured rat pulmonary endothelial cells. Am J Physiol. 1997, 273: L768-L744.
PubMed
Google Scholar
Golden CL, Kohler JD, Nick HS, Visner GA: Effects of vasoactive and inflammatory mediators on endothelin-1 expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 1995, 12: 503-512.
PubMed
Google Scholar
Li H, Chen SJ, Cheng Q, Durand J, Oparil S, Elton TS: Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol. 1994, 77: 1452-1459.
Google Scholar
Hassoun PM, Thappa V, Landman MJ, Fanburg BL: Endothelin 1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med. 1992, 166: 165-170.
Google Scholar
Aversa CR, Oparil S, Caro J, Li H, Sun S-D, Chen Y-F, Swerdel MR, Monticello TM, Durhan SK, Minchenko A, Lira SA, Webb ML: Hypoxia stimulates human prepro endothelin-1 promoter activity in transgenic mice. Am J Physiol. 1997, 273: L848-L855.
PubMed
Google Scholar
Weibke JL, Montrose-Rafizadeh C, Zeitlein PL, Guggino WB: Effect of hypoxia on endothelin-1 production by vascular endothelial cells. Biochem Biophys Acta. 1992, 1134: 105-111.
Google Scholar
Fukuroda T, Kobayashi M, Ozaki S, Yano M, Miyauchi T, Onizuka M, Sugishita Y, Goto K, Nishikibe M: Endothelin receptor subtypes in human vs rabbit pulmonary arteries. J Appl Physiol. 1994, 76: 1976-1982.
PubMed
Google Scholar
Soma S, Takahashi H, Muramatsu M, Oka M, Fukudu Y: Localization and distribution of endothelin receptor subtypes in pulmonary vasculature of normal and hypoxia exposed rats. Am J Respir Cell Mol Biol. 1999, 20: 620-630.
PubMed
Google Scholar
Hatakeyana H, Miyamori I, Yamagishi S, Takeda Y, Takeda H, Yamamoto H: Angiotensin II up-regulates the expression of type A endothelin receptors in human vascular smooth muscle cells. Biochem Mol Biol Int. 1994, 34: 127-134.
Google Scholar
Li H, Elton TS, Chen Y-F, Oparil S: Increased endothelin receptor gene expression in hypoxic rats. Am J Physiol. 1994, 266: L553-L560.
PubMed
Google Scholar
DeNucci G, Thomas R, D'Orleans-Juste , Antunes E, Walder C, Warner TD, Vane JR: Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium derived relaxing factor. Proc Natl Acad Sci. 1988, 85: 9797-9800.
Google Scholar
Hasunuma K, Rodman DM, O'Brien RF, McMurtry IF: Endothelin-1 causes pulmonary vasodilation in rats. Am J Physiol. 1990, 259: H48-H54.
PubMed
Google Scholar
Muramatsu M, Oka M, Morio Y, Soma S, Takahashi H, Fukuchi Y: Chronic hypoxia augments endothelin-B receptor mediated vasodilation in isolated perfused rat lung. Am J Physiol. 1999, 276: L358-L364.
PubMed
Google Scholar
Sato K, Rodman DM, McMurtry IF: Hypoxia inhibits ETB receptor mediated NO synthesis in hypoxic rat lungs. Am J Physiol. 1999, 270: L511-L518.
Google Scholar
Muramatsu M, Rodman DM, Oka M, MucMurtry IF: Endothelin-1 mediated nitro-L-arginine vasoconstriction of hypertensive rat lungs. Am J Physiol. 1997, 272: L807-L812.
PubMed
Google Scholar
McLean MR, McCulloch KM, Baird M: Endothelin ETA- and ETB-receptor mediated vasoconstriction in rat pulmonary arteries and arterioles. J Cardiovasc Pharmacol. 1994, 23: 838-845.
Google Scholar
Schmeck J, Gluth H, Mihaljevic N, Born M, Wendel-Wellner M, Krafft P: ET-1 induced vasoconstriction shifts from ETA- to ETB-receptor mediated reaction after preconstriction. J Appl Physiol. 1999, 87: 2284-2289.
PubMed
Google Scholar
Oparil S, Chen SJ, Meng Q-C, Elton TS, Yano M, Chen Y-F: Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am J Physiol. 1995, 268: L95-L100.
PubMed
Google Scholar
Sato K, Morio Y, Morris KG, Rodman DM, McMurtry IF: Mechanism of hypoxic vasoconstriction involves ETa receptor-mediated inhibition of K-ATP channels. Am J Physiol. 2000, 278: L434-L442.
Google Scholar
Nakanishi K, Tajima F, Nakata Y, Osada H, Tachibana S, Kawai T, Torihata L, Suga T, Takishina K, Aurues T, Ikeda T: Expression of endothelin-1 in rats developing hypobaric-hypoxia induced pulmonary hypertension. Lab Invest. 1999, 79: 1347-1357.
PubMed
Google Scholar
DiCarlo VS, Chen SJ, Meng QC, Durand J, Yano M, Chen Y-F, Oparil S: ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am J Physiol. 1995, 269: L690-L697.
PubMed
Google Scholar
Bonvallet ST, Zamora MR, Hasunuma K, Sato K, Hanasato N, Anderson D, Sato K, Stelzner TJ: BQ-123, and ETa-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol. 1994, 266: H1327-H1331.
PubMed
Google Scholar
Aguirre JT, Morrell NW, Long L, Clift P, Upton PD, Polak JM, Wilkins MR: Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol. 2000, 278: L981-L987.
Google Scholar
Stelzner TJ, O'Brien RF, Yanigisawa M, Sakurai T, Sato K, Webb S, Zamora MR, Fisher JH: Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol. 1992, 262: L614-L620.
PubMed
Google Scholar
Frasch HF, Marshall C, Marshall BE: Endothelin-1 is elevated in monocrotaline pulmonary hypertension. Am J Physiol. 1999, 276: L304-L310.
PubMed
Google Scholar
Hill NS, Warburton RR, Pietras L, Klinger JR: Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats. J Appl Physiol. 1997, 83: 1209-1215.
PubMed
Google Scholar
Mansoor AM, Honda M, Saida K, Ishinaga Y, Kuramochi T, Maeda A, Takabatahe T, Mitsui Y: Endothelin induced collagen remodeling in experimental pulmonary hypertension. Biochem Biophys Res Commun. 1995, 210: 981-986.
Google Scholar
Miyauchi T, Yorikani R, Sakai T, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K: Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res. 1993, 73: 887-897.
PubMed
Google Scholar
Zamora MR, Stelzner TJ, Webb S, Panos RJ, Ruff LJ, Dempsey EC: Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn hooded rat. Am J Physiol. 1996, 270: L101-L109.
PubMed
Google Scholar
Hocher B, Schwarz A, Fagan KA, Thone-Reineke C, El-Hag K, Kusserow H, Elitok S, Bauer C, Neumayer H-H, Rodman DM, Theuring F: Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am J Respir Cell Mol Biol. 2000, 23: 19-26.
PubMed
Google Scholar
Lee SD, Shroyer KR, Markham NE, Cool CD, Voelkel NF, Tuder RM: Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest. 1998, 101: 927-934.
PubMed
PubMed Central
Google Scholar
Stewart DJ, Levy RD, Chernacek P, Langleben D: Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease. Ann Int Med. 1991, 114: 464-469.
PubMed
Google Scholar
Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Path FRC, Stewart DJ: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Engl J Med. 1993, 328: 1732-1739.
PubMed
Google Scholar
Cacoub P, Dorent R, Nataf P, Carayon A, Riquet M, Noe E, Piette JC, Godeau P, Gandjbakhch I: Endothelin-1 in the lungs of patients with pulmonary hypertension. Cardiovasc Res. 1997, 33: 196-200.
PubMed
Google Scholar
Langleben D, Barst RJ, Badesch D, Groves BM, Tapson VF, Nurali S, Bourge RC, Ettinger N, Shalit E, Clayton LM, Jobsis MM, Blackburn SD, Crow JW, Stewart DJ, Long W: Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension. Circulation. 1999, 99: 3266-3271.
PubMed
Google Scholar
Shennib H, Serrick C, Saleh D, Reis A, Stewart DJ, Giaid A: Plasma endothelin-1 levels in human lung transplant recipients. J Cardiovasc Pharmacol. 1995, 26 (suppl 3): S516-S518.
Google Scholar
Jeppsson A, Tazelaar HD, Miller VM, McGregor CGA: Distribution of endothelin-1 in transplanted human lungs. Transplantation. 1998, 66: 806-809.
PubMed
Google Scholar
Giaid A, Polak JM, Gaitonde V, Hamid QA, Moscoso G, Legon S, Uwanogho D, Roncalli M, Shinmi O, Sawamira T, Kimura S, Yanagisawa M, Masaki T, Springall DR: Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am J Respir Cell Mol Biol. 1991, 4: 50-58.
PubMed
Google Scholar
Cale ARJ, Ricagna F, Wiklund L, McGregor CGA, Miller VM: Mononuclear cells from dogs with acute lung allograft rejection cause contraction of pulmonary arteries. Circulation. 1994, 90: 952-958.
PubMed
Google Scholar
Zhao YD, Springall DR, Hamid Q, Yacoub MH, Levene M, Polak JM: Localization and characterization of endothelin-1 binding sites in the transplanted human lung. J Cardiovasc Pharmacol. 1995, 26 (suppl 3): S336-S340.
Google Scholar
Allison RC, Kyle J, Adkins WK, Prasad VR, McCord JM, Taylor AE: Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance. J Appl Physiol. 1990, 69: 597-603.
PubMed
Google Scholar
Shennib H, Serrick C, Saleh D, Adoumie R, Stewart J, Giaid A: Alterations in bronchoalveolar lavage and plasma endothelin-1 levels early after lung transplantation. Transplantation. 59: 994-998.
Doi S, Smedira N, Murray PA: Pulmonary vasoregulation by endothelium in conscious dogs after left lung transplantation. J Appl Physiol. 2000, 88: 210-218.
PubMed
Google Scholar
Shennib H, Lee AGL, Kuang JQ, Yanagisawa M, Ohlstein EH, Giaid A: Efficacy of administering an endothelin-receptor antagonist (B209670) in ameliorating ischemia-reperfusion injury in lung allografts. Am J Respir Crit Care Med. 1998, 1975-1981.
Google Scholar
Vemulapalli S, Rivelli M, Chin PJS, delPrado M, Hey JA: Phosphoramidon abolishes the increased in endothelin-1 release induced by ischemia-hypoxia in isolated perfused guinea pig lungs. J Pharmacol Exp Ther. 1992, 262: 1062-1069.
PubMed
Google Scholar
Sunose Y, Takeyoshi I, Ohwada S, Iwazaki S, Aiba M, Tomizawa N, Tsutsumi H, Oriuchi N, Matsumoto K, Morishita Y: The effect of FK409 - a nitric oxide donor - on canine lung transplantation. J Heart Lung Transpl. 2000, 19: 298-309.
Google Scholar
Schersten H, Aarino P, Burnett JC, McGregor CGA, Miller VM: Endothelin-1 in bronchoalveolar lavage during rejection of allotransplanted lungs. Transplantation. 1994, 57: 159-161.
PubMed
Google Scholar
Scott JP, Higenbottam TW, Sharples L, Clelland CA, Smyth RL, Stewart S, Wallwork J: Risk factors for obliterative bronchiolitis in heart-lung transplant recipients. Transplantation. 1991, 51: 813-817.
PubMed
Google Scholar
Dubin D, Pratt RE, Cooke JP, Dzau VJ: Endothelin, a potent vasoconstrictor is a vascular smooth muscle mitogen. J Vasc Med Biol. 1989, 1: 150-
Google Scholar
Nelson JB, Chan-Tack K, Hedican SP, Magnuson SR, Opgenorth , Bova GS, Simons JW: Endothelin-1 and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res. 1996, 56: 663-668.
PubMed
Google Scholar
Ali H, Loizidou M, Dashwood M, Savage F, Sheard C, Taylor I: Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists. Gut. 2000, 47: 685-688. 10.1136/gut.47.5.685.
PubMed
PubMed Central
Google Scholar
Drimal J, Drimal J, Drimal D: Enhanced endothelin ETB receptor down-regulation in human tumor cells. Eur J Pharmacol. 2000, 396: 19-22.
PubMed
Google Scholar
Alanen K, Deng DX, Chakrabarti S: Augmented expression of endothelin-1, endothelin-3, and the endothelin-B receptor in breast carcinoma. Histopathology. 2000, 36: 161-167. 10.1046/j.1365-2559.2000.00795.x.
PubMed
Google Scholar
Lahav R, Heffner G, Patterson PH: An endothelin receptor b antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc Natl Acad Sci USA. 1999, 96: 11496-11500.
PubMed
PubMed Central
Google Scholar
Eberl LP, Valdenaire O, Saintgiorgio V, Jeannin JF, Juillerat-Jenneret L: Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells. Int J Cancer. 2000, 86: 182-187. 10.1002/(SICI)1097-0215(20000415)86:2<182::AID-IJC6>3.3.CO;2-7.
PubMed
Google Scholar
Giaid A, Hamid QA, Springall DR, Yanagisawa M, Shinmi O, Sawamura T, Masaki T, Kimura S, Corrin B, Polak JM: Detection of endothelin immunoreactivity and mRNA in pulmonary tumors. J Pathol. 1990, 162: 15-22.
PubMed
Google Scholar
Cohen AJ, Gilman LB, Miller YE: Endothelin receptor expression in lung cancer cell lines and bronchial epithelial cell lines [abstract]. FASEB J. 1997, 11: A3221-
Google Scholar
Cohen AJ, Yanagisawa M, Zamora M, Gilman L, Bunn P, Franklin W, Miller Y: Evidence for an endothelin-1 autocrine loop in lung cancer. Lung Cancer. 1997, 18 (suppl): 574-
Google Scholar
Ahmed SI, Thompson J, Coulson JM, Woll PJ: Studies on the expression of endothelin, its receptor subtypes and converting enzymes in lung cancer and human bronchial epithelium. Am J Respir Cell Mol Biol. 2000, 22: 422-431.
PubMed
Google Scholar
Pedram A, Razandi M, Hu R-M, Levin E: Vasoactive peptides modulate vascular endothelin cell growth factor production and endothelial cell proliferation and invasion. J Biol Chem. 1997, 272: 17097-17103.
PubMed
Google Scholar
Dawas K, Loizidou M, Shankar A, Ali H, Taylor I: Angiogenesis in cancer: the role of endothelin-1. Ann R Coll Surg Eng. 1999, 81: 306-310.
Google Scholar
Zhao YD, Springall DR, Hamid Q, Levene M, Polak JM: Localization and characterization of endothelin-1 receptor binding in the blood vessels of human pulmonary tumors. J Cardiovasc Pharmacol. 1995, 261 (suppl 3): S341-S345.
Google Scholar
Bell KM, Chaplin DM: The effect of oxygen and carbon dioxide on tumor endothelin-1 production. J Cardiovasc Pharmacol. 1998, 33 (suppl 3): S537-S540.
Google Scholar
Simmet T, Pritze S, Thelen KI, Peskar BA: Released endothelin in oleic acid-induced respiratory distress syndrome. Eur J Pharmacol. 1992, 211: 319-322.
PubMed
Google Scholar
Druml W, Steltzer H, Waldhausl W, Lenz K, Hammerle A, Vierhapper H, Gasic S, Wagner OF: Endothelin-1 in adult respiratory distress syndrome. Am Rev Respir Dis. 1993, 148: 1169-1173.
PubMed
Google Scholar
Sanai L, Haynes WG, Mackenzie A, Grant IS, Webb DJ: Endothelin production in sepsis and the adult respiratory distress syndrome. Intensive Care Med. 1996, 22: 52-56.
PubMed
Google Scholar
Langleben D, DeMarchie M, Laporta D, Spanier AH, Schlesinger RD, Stewart DJ: Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Respir Dis. 1993, 148: 1646-1650.
PubMed
Google Scholar
Asakura H, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E, Yamazaki M, Matsuda T: Role of endothelin in disseminated intravascular coagulation. Am J Hematol. 1992, 41: 71-75.
PubMed
Google Scholar
Huribal M, Cunningham ME, D'Aiuto ML, Pleban WE, McMillen MA: Endothelin-1 and prostaglandin E2 levels increase in patients with lung injury. J Am Coll Surg. 1995, 180: 318-322.
PubMed
Google Scholar
Mitaka C, Hirata Y, Nagura T, Tsunoda Y, Amaha K: Circulating endothelin-1 concentrations in acute respiratory failure. Chest. 1993, 104: 476-480.
PubMed
Google Scholar
Albertine KH, Wana ZM, Michael JR: Expression of endothelial nitric oxide synthase, inducible nitric oxide synthase and endothelin-1 in lungs of subjects who died with ARDS. Chest. 1999, 116: 1015-1025.
Google Scholar
McMillen MA, Sumpio BE: Endothelins: polyfunctional peptides. J Am Coll Surg. 1995, 180: 621-637.
PubMed
Google Scholar
Lehoux S, Plante GE, Sirois MG, Sirosis P, D'Orleans-Juste P: Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat. Br J Pharmacol. 1992, 107: 996-1000.
PubMed
PubMed Central
Google Scholar
Helset E, Kjaeve J, Hauge A: Endothelin-1-induced increase in microvascular permeability in isolated perfused rat lungs requires leukocytes and plasma. Circ Shock. 1993, 39: 15-20.
PubMed
Google Scholar
Rodman DM, Stelzner TJ, Zamora MR, Bonvalet ST, Oka M, Sato K, O'Brien RF, McMurtry IF: Endothelin-1 increases the pulmonary microvascular pressure and causes pulmonary edema in salt-solution but not blood perfused rat lungs. J Cardiovasc Pharmacol. 1992, 20: 658-663.
PubMed
Google Scholar
Filep JG, Foldes-Filep E, Rousseau A, Sirois P, Fournier A: Vascular responses to endothelin-1 following inhibition of nitric oxide synthase in the conscious rat. Br J Pharmacol. 1993, 110: 1213-1221.
PubMed
PubMed Central
Google Scholar
Schmeck J, Heller A, Groschler A, Recker A, Neuhof H, Urbascheck R, Koch T: Impact of endothelin-1 in endotoxin-induced pulmonary vascular reactions. Crit Care Med. 2000, 28: 2851-2857.
PubMed
Google Scholar
Uchida Y, Ninomiya N, Sakamoto T, Lee JY, Endo T, Nomura A, Hasegawa S, Hirata F: ET-1 released histamine from guinea pig pulmonary but not peritoneal mast cells. Biochem Biophys Res Commun. 1992, 189: 1196-1201.
PubMed
Google Scholar
Khalil N, Bereznay O, Sporn M, Greenberg AH: Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med. 1989, 170: 727-737.
PubMed
Google Scholar
Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P: Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med. 1989, 170: 655-663.
PubMed
Google Scholar
Peacock AJ, Dawes KE, Shock A, Gray AJ, Reeves JT, Lauert GL: Endothelin 1 and endothelin 3 induced chemotaxis and replication of pulmonary fibroblasts. Am J Respir Cell Mol Biol. 1992, 7: 492-499.
PubMed
Google Scholar
Shahar I, Fireman E, Topilsky M, Grief J, Schwarz Y, Kivity S, Ben-Efrain S, Spirer Z: Effect of endothelin-1 on alpha smooth muscle actin expression and on alveolar fibroblast proliferation in interstitial lung diseases. Int J Immunopharmacol. 1999, 21: 759-775.
PubMed
Google Scholar
Cambrey AD, Harrison NK, Dawes KE, Southcott AM, Black CM, DuBois DM, Laurent GL, McAnulty RJ: Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast migration and activity in vitro. Am J Respir Cell Mol Biol. 1994, 11: 439-445.
PubMed
Google Scholar
Guidry C, Hook M: Endothelin produced by endothelial cells promotes collagen gel contraction by fibroblasts. J Cell Biol. 1991, 115: 873-880.
PubMed
Google Scholar
Guarda E, Katwa LC, Myers PR, Tyagi SC, Weber KT: Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovsac Res. 1993, 27: 2130-2134.
Google Scholar
Villaschi S, Nicosia RF: Paracrine interaction between fibroblast and endothelial cells in a serum-free coculture model: modulation of angiogenesis and collagen gel contraction. Lab Invest. 1994, 71: 291-299.
PubMed
Google Scholar
Marini M, Carpi S, Bellini A, Patalano F, Mattoli S: Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells. Biochem Biophys Res Commun. 1996, 220: 896-899. 10.1006/bbrc.1996.0502.
PubMed
Google Scholar
Uguccioni M, Pulsatelli L, Grigolo B, Facchini A, Fasano C, Cinti C, Fabbri M, Gasbarrini G, Meliconi R: Endothelin-1 in idiopathic pulmonary fibrosis. J Clin Pathol. 1995, 48: 330-334.
PubMed
PubMed Central
Google Scholar
Giaid A, Michael RP, Steward DJ, Sheppard M, Corrin B, Hamid Q: Expresison of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet. 1993, 341: 1550-1554.
PubMed
Google Scholar
Morelli S, Ferri C, Polettini E, Bellini C, Gualdi GF, Pittoni V, Valesini G, Santucci A: Plasma endothelin-1 levels, pulmonary hypertension, and lung fibroblasts with systemic sclerosis. Am J Med. 1995, 99: 255-260.
PubMed
Google Scholar
Vancheeswaran R, Magoulas T, Efrat G, Wheeler-Jones C, Olsen I, Penny R, Black CM: Circulating endothelin-1 levels in systemic sclerosis subsets - a marker of fibrosis or vascular dysfunction. J Rheumatol. 1994, 21: 1838-1844.
PubMed
Google Scholar
Abraham DJ, Vancheeswaran ZR, Dashwood MR, Rajkumar VS, Pantelides P, X SW, duBois RM, Black CM: Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung diseases. Am J Pathol. 1997, 151: 81-841.
Google Scholar
Odoux C, Crestani B, Lebrun , Rolland C, Aubin P, Seta N, Kahn MF, Fiet J, Aubier M: Endothelin secretion by alveolar macrophages in systemic sclerosis. Am J Respir Crit Care Med. 1997, 156: 1429-1435.
PubMed
Google Scholar
Mustaers SE, Foster ML, Chambers RC, Laurent GL, McAnulty RJ: Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in the rat. Am J Respir Cell Mol Biol. 1998, 18: 611-619.
Google Scholar
Park SH, Saleh D, Giaid A, Michael RP: Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of endothelin receptor antagonists. Am J Respir Crit Care Med. 1997, 156: 600-608.
PubMed
Google Scholar
Mutsaers SE, Marshall RP, Goldsack NR, Laurent GL, McAnulty RJ: Effect of endothelin receptor antagonists (BQ485, RO 47-0203) on collage deposition during development of bleomycin-induced pulmonary fibrosis in rats. Pulmon Pharmacol Ther. 1998, 11: 221-225.
Google Scholar
Hocher B, Thone-Reineke , Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T, Bauer C, Newmayer HH, Schleuning W-D, Theuring F: Endothelin-1 transgenic mice develop glomeulerosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest. 1997, 99: 1380-1389.
PubMed
PubMed Central
Google Scholar
Teder P, Nobel PW: A cytokine reborn? Endothelin-1 in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2000, 23: 7-10.
PubMed
Google Scholar