Table 1 Human diseases in which endothelin-1 may be implicated

Airway diseases

   Asthma

   Chronic obstructive pulmonary disease

   Bronchiectasis

   Bronchiolitis obliterans

Parenchymal lung diseases

   Pulmonary fibrosis

   Idiopathic

   Connective tissue associated

Neoplastic diseases

   Lung malignancies

   Metastases to lung

Pulmonary vascular diseases

   Primary pulmonary hypertension

   Secondary pulmonary hypertension

Connective tissue diseases

Congenital heart disease

Acute lung injury

   Ischemia/reperfusion

   Pulmonary edema

   Acute respiratory distress syndrome

   Sepsis

Lung transplant rejection

   Acute: ischemia/reperfusion injury

   Chronic: bronchiolitis obliterans