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  1. Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been ...

    Authors: Harald Renz
    Citation: Respiratory Research 2001 2:265
  2. The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tac...

    Authors: R Stokes Peebles Jr and Barney S Graham
    Citation: Respiratory Research 2001 2:245
  3. The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105→Val105 substitution are associated with the asthma pheno...

    Authors: Anja Hemmingsen, Anthony A Fryer, Michael Hepple, Richard C Strange and Monica A Spiteri
    Citation: Respiratory Research 2001 2:255
  4. Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve activity can be subclassified into compounds that...

    Authors: Bradley J Undem and Michael J Carr
    Citation: Respiratory Research 2001 2:234
  5. Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertens...

    Authors: Mark W Geraci, Bifeng Gao, Yasushi Hoshikawa, Michael E Yeager, Rubin M Tuder and Norbert F Voelkel
    Citation: Respiratory Research 2001 2:210
  6. The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmon...

    Authors: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget and Norbert Verbeke
    Citation: Respiratory Research 2001 2:198
  7. X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency caused by disruption of the Bruton's tyrosine kinase (BTK) gene. Typical XLA patients suffer recurrent and severe bacterial infections in childhood.

    Authors: Kazuhiro Usui, Yoji Sasahara, Ryushi Tazawa, Koichi Hagiwara, Satoshi Tsukada, Toshio Miyawaki, Shigeru Tsuchiya and Toshihiro Nukiwa
    Citation: Respiratory Research 2001 2:188
  8. The hygiene hypothesis, as originally proposed, postulated an inverse relation between the incidence of infectious diseases in early life and the subsequent development of allergies and asthma. New evidence fr...

    Authors: Fernando D Martinez
    Citation: Respiratory Research 2001 2:129
  9. The availability of molecular tools to carry out genotyping has led to a flurry of association studies between specific genes and clinical indices of disease or disease susceptibility. Human studies, for the m...

    Authors: Mitchell L Drumm
    Citation: Respiratory Research 2001 2:125
  10. Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of th...

    Authors: Scott Greenfeder, Shelby P Umland, Francis M Cuss, Richard W Chapman and Robert W Egan
    Citation: Respiratory Research 2001 2:71
  11. Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediato...

    Authors: Karen A Fagan, Ivan F McMurtry and David M Rodman
    Citation: Respiratory Research 2001 2:90
  12. The pathogenesis of cryptogenic fibrosing alveolitis (CFA) involves injury, an immune/inflammatory response and fibrosis. The cause of the injury is unknown, but the identification of serum autoantibodies make...

    Authors: Suveer Singh and Ron du Bois
    Citation: Respiratory Research 2001 2:61
  13. The pathogenetic mechanisms that underlie the interstitial lung disease cryptogenic fibrosing alveolitis (CFA) may involve an immunological reaction to unidentified antigens in the lung, resulting in tissue da...

    Authors: Cleo Robinson, Marinella Callow, Sandra Stevenson, Bruce WS Robinson and Richard A Lake
    Citation: Respiratory Research 2001 2:119
  14. Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil tra...

    Authors: John W Steinke and Larry Borish
    Citation: Respiratory Research 2001 2:66
  15. Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airfl...

    Authors: David A Lomas and Edwin K Silverman
    Citation: Respiratory Research 2001 2:20
  16. The morbidity and mortality from asthma have markedly increased since the late 1970s. The hospitalization rate, an important marker of asthma severity, remains substantial.

    Authors: Mark D Eisner, Patricia P Katz, Edward H Yelin, Stephen C Shiboski and Paul D Blanc
    Citation: Respiratory Research 2000 2:4
  17. Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been...

    Authors: William C Parks and Steven D Shapiro
    Citation: Respiratory Research 2000 2:3
  18. Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor α (GRα), which represses numerous genes encoding pro-inflamma...

    Authors: Rosalia Gagliardo, Antonio M Vignola and Marc Mathieu
    Citation: Respiratory Research 2000 2:1
  19. The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal...

    Authors: Paul J Wolters and Harold A Chapman
    Citation: Respiratory Research 2000 1:9
  20. Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. ...

    Authors: William H Westra
    Citation: Respiratory Research 2000 1:8
  21. Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T...

    Authors: Willi K Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L O'Brien and Erwin W Gelfand
    Citation: Respiratory Research 2000 1:6

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