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  1. In the backdrop of conflicting reports (some studies reported adverse outcomes of biomass fuel use whereas few studies reported absence of any association between adverse health effect and fuel use, may be due...

    Authors: Asim Saha, N Mohan Rao, PK Kulkarni, PK Majumdar and HN Saiyed
    Citation: Respiratory Research 2005 6:127
  2. We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S. pneumoniae was investigated in viv...

    Authors: R Jounblat, H Clark, P Eggleton, S Hawgood, PW Andrew and A Kadioglu
    Citation: Respiratory Research 2005 6:126
  3. Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-der...

    Authors: Y Gaël Rochefort, Pascal Vaudin, Nicolas Bonnet, Jean-Christophe Pages, Jorge Domenech, Pierre Charbord and Véronique Eder
    Citation: Respiratory Research 2005 6:125
  4. Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors. Pharm...

    Authors: Krongkarn Chootip, Alison M Gurney and Charles Kennedy
    Citation: Respiratory Research 2005 6:124
  5. Alcohol abuse has long been known to adversely affect innate and adaptive immune responses and pre-dispose to infections. One cellular mechanism responsible for this effect is alcohol-induced suppression of TN...

    Authors: Kejing Song, Xue-Jun Zhao, Luis Marrero, Peter Oliver, Steve Nelson and Jay K Kolls
    Citation: Respiratory Research 2005 6:123
  6. Neurotoxicity and pulmonary dysfunction are well-recognized problems associated with prolonged human exposure to high concentrations of airborne manganese. Surprisingly, histological characterization of pulmon...

    Authors: David C Dorman, Melanie F Struve, Elizabeth A Gross, Brian A Wong and Paul C Howroyd
    Citation: Respiratory Research 2005 6:121
  7. Recent studies have demonstrated marked international variations in the prevalence of asthma, but less is known about ethnic variations in asthma epidemiology within individual countries and in particular the ...

    Authors: Gopalakrishnan Netuveli, Brian Hurwitz and Aziz Sheikh
    Citation: Respiratory Research 2005 6:120
  8. The role of leukotriene (LT) B4, a potent inflammatory mediator, in atopic asthmatic and atopic nonasthmatic children is largely unknown. The lack of a gold standard technique for measuring LTB4 in exhaled breath...

    Authors: Paolo Montuschi, Simona Martello, Marialinda Felli, Chiara Mondino, Peter J Barnes and Marcello Chiarotti
    Citation: Respiratory Research 2005 6:119
  9. Extravasation and luminal entry of plasma occurs continuously in the nose. This process is markedly facilitated in patients with symptomatic allergic rhinitis, resulting in an increased secretion of proteins. ...

    Authors: Malin Bryborn, Mikael Adner and Lars-Olaf Cardell
    Citation: Respiratory Research 2005 6:118
  10. The respiratory epithelium is a major portal of entry for pathogens and employs innate defense mechanisms to prevent colonization and infection. Induced expression of human β-defensin 2 (HBD2) represents a dir...

    Authors: Ruth MacRedmond, Catherine Greene, Clifford C Taggart, Noel McElvaney and Shane O'Neill
    Citation: Respiratory Research 2005 6:116
  11. Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepit...

    Authors: Markus Weichselbaum, Malcolm P Sparrow, Elisha J Hamilton, Philip J Thompson and Darryl A Knight
    Citation: Respiratory Research 2005 6:115
  12. Human rhinoviruses (RV), the most common triggers of acute asthma exacerbations, are considered not cytotoxic to the bronchial epithelium. Recent observations, however, have questioned this knowledge. The aim ...

    Authors: Apostolos Bossios, Stelios Psarras, Dimitrios Gourgiotis, Chrysanthi L Skevaki, Andreas G Constantopoulos, Photini Saxoni-Papageorgiou and Nikolaos G Papadopoulos
    Citation: Respiratory Research 2005 6:114
  13. The adenoviral protein E1A has been proposed to play a role in the pathophysiology of COPD, in particular by increasing IL-8 gene transcription of lung epithelial cells in response to cigarette smoke-constitue...

    Authors: Arjen van den Berg, Mieke Snoek, Henk M Jansen and René Lutter
    Citation: Respiratory Research 2005 6:111
  14. Laminins are a group of proteins largely responsible for the anchorage of cells to basement membranes. We hypothesized that altered Laminin chain production in the bronchial mucosa might explain the phenomenon...

    Authors: Kawa Amin, Christer Janson, Lahja Sevéus, Kaoru Miyazaki, Ismo Virtanen and Per Venge
    Citation: Respiratory Research 2005 6:110
  15. Chronic hypoxia influences gene expression in the lung resulting in pulmonary hypertension and vascular remodelling. For specific investigation of the vascular compartment, laser-microdissection of intrapulmon...

    Authors: Grazyna Kwapiszewska, Jochen Wilhelm, Stephanie Wolff, Isabel Laumanns, Inke R Koenig, Andreas Ziegler, Werner Seeger, Rainer M Bohle, Norbert Weissmann and Ludger Fink
    Citation: Respiratory Research 2005 6:109
  16. Exhaled nitric oxide (eNO) is decreased by cigarette smoking. The hypothesis that oxides of nitrogen (NOX) in cigarette smoke solution (CSS) may exert a negative feedback mechanism upon NO release from epithelial...

    Authors: Xiu M Wei, Henry S Kim, Rakesh K Kumar, Gavin J Heywood, John E Hunt, H Patrick McNeil and Paul S Thomas
    Citation: Respiratory Research 2005 6:108
  17. Particulate matter (PM) can exacerbate allergic airway diseases. Although health effects of PM with a diameter of less than 100 nm have been focused, few studies have elucidated the correlation between the siz...

    Authors: Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Miho Sakurai, Takamichi Ichinose, Kaori Sadakane and Toshikazu Yoshikawa
    Citation: Respiratory Research 2005 6:106
  18. Recent studies suggest that HCV infection is associated with progressive declines in pulmonary function in patients with underlying pulmonary diseases such as asthma and chronic obstructive pulmonary disease. ...

    Authors: Jonathan P Moorman, S Matthew Fitzgerald, Deborah C Prayther, Steven A Lee, David S Chi and Guha Krishnaswamy
    Citation: Respiratory Research 2005 6:105
  19. Increasing clinical epidemiological and experimental evidence indicates that excess of production of reactive oxygen free radicals (ROS) induced by an oxidative stress is involved in the pathogenesis of a numb...

    Authors: MG Matera, L Calzetta, A Peli, A Scagliarini, C Matera and M Cazzola
    Citation: Respiratory Research 2005 6:104
  20. T lymphocytes are demonstrated to play an important role in several chronic pulmonary inflammatory diseases. In this study we provide evidence that human lung fibroblasts are capable of mutually interacting wi...

    Authors: Carlo Vancheri, Claudio Mastruzzo, Elisa Trovato-Salinaro, Elisa Gili, Debora Lo Furno, Maria P Pistorio, Massimo Caruso, Cristina La Rosa, Claudia Crimi, Marco Failla and Nunzio Crimi
    Citation: Respiratory Research 2005 6:103
  21. Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferato...

    Authors: Tom Hsun-Wei Huang, Valentina Razmovski-Naumovski, Bhavani Prasad Kota, Diana Shu-Hsuan Lin and Basil D Roufogalis
    Citation: Respiratory Research 2005 6:102
  22. In longitudinal studies on Health Related Quality of Life (HRQL) it frequently occurs that patients have one or more missing forms, which may cause bias, and reduce the sample size. Aims of the present study w...

    Authors: Karin M Vermeulen, Wendy J Post, Mark M Span, Wim van der Bij, Gerard H Koëter and Elisabeth M TenVergert
    Citation: Respiratory Research 2005 6:101
  23. Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors ...

    Authors: Mattias Fransson, Mikael Adner, Jonas Erjefält, Lennart Jansson, Rolf Uddman and Lars-Olaf Cardell
    Citation: Respiratory Research 2005 6:100
  24. The GOLD classification of COPD severity introduces a stage 0 (at risk) comprising individuals with productive cough and normal lung function. The aims of this study were to investigate total mortality risks i...

    Authors: Marie Ekberg-Aronsson, Kerstin Pehrsson, Jan-Åke Nilsson, Peter M Nilsson and Claes-Göran Löfdahl
    Citation: Respiratory Research 2005 6:98
  25. The pulmonary surfactant protein (SP)-A has potent immunomodulatory activities but its role and regulation during allergic airway inflammation is unknown.

    Authors: Seth Thomas Scanlon, Tatyana Milovanova, Sonja Kierstein, Yang Cao, Elena N Atochina, Yaniv Tomer, Scott J Russo, Michael F Beers and Angela Haczku
    Citation: Respiratory Research 2005 6:97
  26. A progressive lung disease and a worse survival have been observed in patients with systemic sclerosis and alveolitis. The objective of this study was to define the functional, radiological and biological mark...

    Authors: Maria De Santis, Silvia Bosello, Giuseppe La Torre, Anna Capuano, Barbara Tolusso, Gabriella Pagliari, Riccardo Pistelli, Francesco Maria Danza, Angelo Zoli and Gianfranco Ferraccioli
    Citation: Respiratory Research 2005 6:96
  27. Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and ...

    Authors: Roberto de Marco, Francesca Locatelli, Lucia Cazzoletti, Massimilian Bugianio, Aurelia Carosso and Alessandra Marinoni
    Citation: Respiratory Research 2005 6:95
  28. Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP β-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR allel...

    Authors: Massimo Amicosante, Floriana Berretta, Milton Rossman, Richard H Butler, Paola Rogliani, Ella van den Berg-Loonen and Cesare Saltini
    Citation: Respiratory Research 2005 6:94
  29. Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion of the MCP-1 receptor CCR2 pro...

    Authors: Dominik Hartl, Matthias Griese, Thomas Nicolai, Gernot Zissel, Christine Prell, Dietrich Reinhardt, Dolores J Schendel and Susanne Krauss-Etschmann
    Citation: Respiratory Research 2005 6:93
  30. Improved outcomes with expanding treatment options for patients with pulmonary arterial hypertension present the opportunity to consider additional end-points in approaching therapy, including factors that inf...

    Authors: Darren B Taichman, Jennifer Shin, Laryssa Hud, Christine Archer-Chicko, Sandra Kaplan, Jeffery S Sager, Robert Gallop, Jason Christie, John Hansen-Flaschen and Harold Palevsky
    Citation: Respiratory Research 2005 6:92
  31. Inflammation is a hallmark of acute lung injury and chronic airway diseases. In chronic airway diseases, it is associated with profound tissue remodeling. Peroxisome proliferator-activated receptor-α (PPARα) i...

    Authors: Carine Delayre-Orthez, Julien Becker, Isabelle Guenon, Vincent Lagente, Johan Auwerx, Nelly Frossard and Françoise Pons
    Citation: Respiratory Research 2005 6:91
  32. Fas receptor-mediated eosinophil apoptosis is currently forwarded as a mechanism resolving asthma-like inflammation. This view is based on observations in vitro and in airway lumen with unknown translatability to...

    Authors: Lena Uller, Kristina Rydell-Törmänen, Carl GA Persson and Jonas S Erjefält
    Citation: Respiratory Research 2005 6:90
  33. Theophylline has been used widely as a bronchodilator for the treatment of bronchial asthma and has been suggested to modulate immune response. While the importance of macrophages in asthma has been reappraise...

    Authors: Pei-Li Yao, Meng-Feng Tsai, Yi-Chen Lin, Chien-Hsun Wang, Wei-Yu Liao, Jeremy JW Chen and Pan-Chyr Yang
    Citation: Respiratory Research 2005 6:89
  34. Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acut...

    Authors: Nicholas W Morrell, Matthew A Higham, Peter G Phillips, B Haleema Shakur, Paul J Robinson and Ray J Beddoes
    Citation: Respiratory Research 2005 6:88
  35. Studies from our laboratory have shown that human alveolar macrophages (AM) and bronchial epithelial cells (HBEC) exposed to ambient particles (PM10) in vitro increase their production of inflammatory mediators a...

    Authors: Hiroshi Ishii, Shizu Hayashi, James C Hogg, Takeshi Fujii, Yukinobu Goto, Noriho Sakamoto, Hiroshi Mukae, Renaud Vincent and Stephan F van Eeden
    Citation: Respiratory Research 2005 6:87
  36. The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS de...

    Authors: Norbert Weissmann, Nermin Kuzkaya, Beate Fuchs, Vedat Tiyerili, Rolf U Schäfer, Hartwig Schütte, Hossein A Ghofrani, Ralph T Schermuly, Christian Schudt, Akylbek Sydykov, Bakytbek Egemnazarow, Werner Seeger and Friedrich Grimminger
    Citation: Respiratory Research 2005 6:86
  37. In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously foun...

    Authors: Dedmer Schaafsma, Reinoud Gosens, I Sophie T Bos, Herman Meurs, Johan Zaagsma and S Adriaan Nelemans
    Citation: Respiratory Research 2005 6:85
  38. Lung fibrosis is characterized by tissue remodeling resulting from an imbalance between synthesis and degradation of extracellular organic matrices. To examine whether cathepsin(s) (Cat) are important in the d...

    Authors: Sybille van den Brûle, Pierre Misson, Frank Bühling, Dominique Lison and François Huaux
    Citation: Respiratory Research 2005 6:84
  39. The separation of emphysema from fibrosis is not as clear-cut as it was thought in early studies. These two pathologies may be present at the same time in human lungs and in mice either instilled with elastoly...

    Authors: Monica Lucattelli, Barbara Bartalesi, Eleonora Cavarra, Silvia Fineschi, Benedetta Lunghi, Piero A Martorana and Giuseppe Lungarella
    Citation: Respiratory Research 2005 6:83
  40. Recent studies suggest that HMG-CoA reductase inhibitors ("statins") may have beneficial effects for patients at risk for some types of infections. We examined the effect of prior outpatient use of statins on ...

    Authors: Eric M Mortensen, Marcos I Restrepo, Antonio Anzueto and Jacqueline Pugh
    Citation: Respiratory Research 2005 6:82
  41. Several studies have implicated a role of inflammation in the pathogenesis of lung damage in idiopathic pulmonary fibrosis (IPF). Parenchymal lung damage leads to defects in mechanics and gas exchange and clin...

    Authors: Zoe Daniil, Panagiota Kitsanta, George Kapotsis, Maria Mathioudaki, Androniki Kollintza, Marilena Karatza, Joseph Milic-Emili, Charis Roussos and Spyros A Papiris
    Citation: Respiratory Research 2005 6:81
  42. Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung diseases. The profile of these p...

    Authors: Matthias Griese, Silja Schumacher, Mohammed Tredano, Manuela Steinecker, Annika Braun, Susan Guttentag, Michael F Beers and Michel Bahuau
    Citation: Respiratory Research 2005 6:80
  43. Exhaled breath condensate (EBC) is a non-invasive method to assess airway inflammation and oxidative stress and may be useful in the assessment of childhood asthma.

    Authors: Sukhbir K Shahid, Sergei A Kharitonov, Nicola M Wilson, Andrew Bush and Peter J Barnes
    Citation: Respiratory Research 2005 6:79
  44. The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an...

    Authors: Argyris Tzouvelekis, George Kouliatsis, Stavros Anevlavis and Demosthenes Bouros
    Citation: Respiratory Research 2005 6:78

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