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  1. Content type: Research

    Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the ...

    Authors: Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He and Depeng Jiang

    Citation: Respiratory Research 2018 19:47

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  2. Content type: Research

    Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be ...

    Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada and Masakazu Ichinose

    Citation: Respiratory Research 2018 19:52

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    The Correction to this article has been published in Respiratory Research 2018 19:116

  3. Content type: Review

    Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative st...

    Authors: Alessandro G. Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A. Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru and Angelo Zinellu

    Citation: Respiratory Research 2018 19:51

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  4. Content type: Research

    Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability...

    Authors: Phuwanat Sakornsakolpat, Jarrett D. Morrow, Peter J. Castaldi, Craig P. Hersh, Yohan Bossé, Edwin K. Silverman, Ani Manichaikul and Michael H. Cho

    Citation: Respiratory Research 2018 19:46

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  5. Content type: Research

    Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...

    Authors: Valérie Besnard, Alain Calender, Diane Bouvry, Yves Pacheco, Catherine Chapelon-Abric, Florence Jeny, Hilario Nunes, Carole Planès and Dominique Valeyre

    Citation: Respiratory Research 2018 19:44

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  6. Content type: Letter to the Editor

    Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in bo...

    Authors: Bart de Brouwer, Marjolein Drent, Jody M. W. van den Ouweland, Petal A. Wijnen, Coline H. M. van Moorsel, Otto Bekers, Jan C. Grutters, Eric S. White and Rob Janssen

    Citation: Respiratory Research 2018 19:45

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  7. Content type: Research

    Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the...

    Authors: A. Padilla-Galo, C. Olveira, L. Fernández de Rota-Garcia, I. Marco-Galve, A. J. Plata, A. Alvarez, F. Rivas-Ruiz, A. Carmona-Olveira, J. J. Cebrian-Gallardo and M. A. Martinez-Garcia

    Citation: Respiratory Research 2018 19:43

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  8. Content type: Research

    Smoking is a leading cause of respiratory infections worldwide. Tobacco particulate matter disrupts iron homeostasis in the lungs and increases the iron content in the airways of smokers. The airway epithelia ...

    Authors: Luis G. Vargas Buonfiglio, Jennifer A. Borcherding, Mark Frommelt, Gavin J. Parker, Bryce Duchman, Oriana G. Vanegas Calderón, Ruth Fernandez-Ruiz, Julio E. Noriega, Elizabeth A. Stone, Alicia K. Gerke, Joseph Zabner and Alejandro P. Comellas

    Citation: Respiratory Research 2018 19:42

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  9. Content type: Research

    Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD).

    Authors: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, C. Magnus Sköld and Åsa M. Wheelock

    Citation: Respiratory Research 2018 19:40

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  10. Content type: Research

    Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms o...

    Authors: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, Sven Nyrén, C. Magnus Sköld and Åsa M. Wheelock

    Citation: Respiratory Research 2018 19:39

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  11. Content type: Research

    Our previous screening study suggested that the cell-adhesions protein Dihydropyrimidinase-like 3 (DPYSL3) was a candidate metastatic lung cancer related molecule. This study aimed to analyze the correlation b...

    Authors: Yang Yang, Yan Jiang, Dong Xie, Ming Liu, Nan Song, Junjie Zhu, Jiang Fan and Chenfang Zhu

    Citation: Respiratory Research 2018 19:41

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  12. Content type: Research

    Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). This Phase IIb study investigated...

    Authors: Edward M. Kerwin, Selwyn Spangenthal, Christine Kollar, Earl St Rose and Colin Reisner

    Citation: Respiratory Research 2018 19:38

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  13. Content type: Research

    The contribution of airway remodeling in chronic obstructive pulmonary disease (COPD) has been well documented, with airway smooth muscle cell proliferation and migration playing a role in the remodeling proce...

    Authors: Xiuqin Ye, Wei Hong, Binwei Hao, Gongyong Peng, Lingmei Huang, Zhuxiang Zhao, Yumin Zhou, Mengning Zheng, Chenglong Li, Chunxiao Liang, Erkang Yi, Jinding Pu, Bing Li and Pixin Ran

    Citation: Respiratory Research 2018 19:37

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  14. Content type: Research

    The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited...

    Authors: Hye Yun Park, Suh-Young Lee, Danbee Kang, Juhee Cho, Hyun Lee, Seong Yong Lim, Ho Il Yoon, Seung Won Ra, Ki Uk Kim, Yeon-Mok Oh, Don D. Sin, Sang-Do Lee and Yong Bum Park

    Citation: Respiratory Research 2018 19:36

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  15. Content type: Letter to the Editor

    We would like to comment on the article entitled “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 stud...

    Authors: Luigi Mario Castello and Mattia Bellan

    Citation: Respiratory Research 2018 19:35

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  16. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers repo...

    Authors: Youhei Takahashi, Atsushi Saito, Hirofumi Chiba, Koji Kuronuma, Kimiyuki Ikeda, Tomofumi Kobayashi, Shigeru Ariki, Motoko Takahashi, Yasushi Sasaki and Hiroki Takahashi

    Citation: Respiratory Research 2018 19:34

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  17. Content type: Research

    Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both ‘obese’ animal mo...

    Authors: Amanda Giesler, Manali Mukherjee, Katherine Radford, Luke Janssen and Parameswaran Nair

    Citation: Respiratory Research 2018 19:33

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  18. Content type: Review

    Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor progn...

    Authors: Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone and Luca Richeldi

    Citation: Respiratory Research 2018 19:32

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  19. Content type: Research

    COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical ...

    Authors: Kristoffer Ostridge, Nicholas P. Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C. Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson

    Citation: Respiratory Research 2018 19:31

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  20. Content type: Research

    The literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations an...

    Authors: Fernando Sergio Leitao Filho, Seung Won Ra, Andre Mattman, Robert S. Schellenberg, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Janice M. Leung, S. F. Paul Man, Shawn D. Aaron, Robert M. Reed and Don D. Sin

    Citation: Respiratory Research 2018 19:30

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  21. Content type: Research

    ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

    Authors: Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand and Cornelius J. Busch

    Citation: Respiratory Research 2018 19:29

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  22. Content type: Research

    Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

    Authors: Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning and Jie Cao

    Citation: Respiratory Research 2018 19:28

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  23. Content type: Research

    Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

    Authors: Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng and Guodong Hu

    Citation: Respiratory Research 2018 19:27

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  24. Content type: Research

    A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...

    Authors: Kate M. Johnson, Stirling Bryan, Shahzad Ghanbarian, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:26

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  25. Content type: Research

    Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

    Authors: Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey and Toby M. Maher

    Citation: Respiratory Research 2018 19:25

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  26. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...

    Authors: Javier Milara, Gracia Hernandez, Beatriz Ballester, Anselm Morell, Inés Roger, P. Montero, Juan Escrivá, José M. Lloris, Maria Molina-Molina, Esteban Morcillo and Julio Cortijo

    Citation: Respiratory Research 2018 19:24

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  27. Content type: Research

    Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

    Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps and Joanna Floros

    Citation: Respiratory Research 2018 19:23

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  28. Content type: Research

    Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

    Authors: Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya and Koichi Omori

    Citation: Respiratory Research 2018 19:22

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  29. Content type: Research

    Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unk...

    Authors: Ashraf Fawzy, Nirupama Putcha, Laura M. Paulin, Carrie P. Aaron, Wassim W. Labaki, MeiLan K. Han, Robert A. Wise, Richard E. Kanner, Russell P. Bowler, R. Graham Barr and Nadia N. Hansel

    Citation: Respiratory Research 2018 19:20

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  30. Content type: Research

    Abnormal apoptosis of lung endothelial cells has been observed in emphysematous lung tissue and has been suggested to be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease...

    Authors: Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen and Ping Chen

    Citation: Respiratory Research 2018 19:21

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  31. Content type: Research

    Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patie...

    Authors: Peter R. Bremner, Ruby Birk, Noushin Brealey, Afisi S. Ismaila, Chang-Qing Zhu and David A. Lipson

    Citation: Respiratory Research 2018 19:19

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  32. Content type: Review

    Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential ...

    Authors: Julien Dimastromatteo, Eric J. Charles and Victor E. Laubach

    Citation: Respiratory Research 2018 19:17

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  33. Content type: Research

    Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...

    Authors: Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi and Lena Uller

    Citation: Respiratory Research 2018 19:16

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  34. Content type: Research

    We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of long-acting bronchodilators on exercise capacity in COPD patients.

    Authors: Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi and Stefano Centanni

    Citation: Respiratory Research 2018 19:18

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    The Correction to this article has been published in Respiratory Research 2018 19:70

  35. Content type: Research

    Accumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution. Their small size facilitates dispersal and subsequent exposur...

    Authors: Angela M. Fonceca, Graeme R. Zosky, Elizabeth M. Bozanich, Erika N. Sutanto, Anthony Kicic, Paul S. McNamara, Darryl A. Knight, Peter D. Sly, Debra J. Turner and Stephen M. Stick

    Citation: Respiratory Research 2018 19:15

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  36. Content type: Research

    Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

    Authors: Mark D. Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E. Lipson, Todd W. Seeley and Peter E. Huber

    Citation: Respiratory Research 2018 19:14

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  37. Content type: Research

    Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael Silva O.

    Citation: Respiratory Research 2018 19:13

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    The Correction to this article has been published in Respiratory Research 2018 19:77

  38. Content type: Review

    Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guideline...

    Authors: Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi and Claus F. Vogelmeier

    Citation: Respiratory Research 2018 19:11

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  39. Content type: Research

    Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increase...

    Authors: Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson and Christer Janson

    Citation: Respiratory Research 2018 19:12

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  40. Content type: Review

    Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in han...

    Authors: Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington and Richard Dekhuijzen

    Citation: Respiratory Research 2018 19:10

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  41. Content type: Letter to the Editor

    Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its tr...

    Authors: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates and Ann B. Millar

    Citation: Respiratory Research 2018 19:9

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  42. Content type: Commentary

    While the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) at rest is known to be associated with prognosis in pulmonary arterial hypertension (PAH), it is unclear if the NT-proBNP response to exercis...

    Authors: J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair and T. M. Berghaus

    Citation: Respiratory Research 2018 19:8

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  43. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. Patients present loss of lung function, dyspnea and dry cough. Diagnosis requires compatible radiologic imaging and, in undeter...

    Authors: Barbara Rindlisbacher, Cornelia Schmid, Thomas Geiser, Cédric Bovet and Manuela Funke-Chambour

    Citation: Respiratory Research 2018 19:7

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  44. Content type: Research

    There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our obje...

    Authors: Theresa A. Laguna, Cynthia B. Williams, Myra G. Nunez, Cole Welchlin-Bradford, Catherine E. Moen, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2018 19:6

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  45. Content type: Research

    Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress t...

    Authors: Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song and Jue Pan

    Citation: Respiratory Research 2018 19:5

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  46. Content type: Research

    Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a...

    Authors: Yinna Wang, Alyssa C. Rezey, Ruping Wang and Dale D. Tang

    Citation: Respiratory Research 2018 19:4

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  47. Content type: Research

    Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from p...

    Authors: E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage and Zissis C. Chroneos

    Citation: Respiratory Research 2018 19:3

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  48. Content type: Research

    Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed t...

    Authors: Manish Bodas, Steven Mazur, Taehong Min and Neeraj Vij

    Citation: Respiratory Research 2018 19:2

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  49. Content type: Letter to the Editor

    Hemokinin-1 (HK-1) is a novel neuropeptide produced by human bronchial cells and macrophages and causes contraction of human bronchi ex vivo. It is also generated by antigen/IgE-activated murine mast cells (MC...

    Authors: Wichayapha Manorak, Chizobam Idahosa, Kshitij Gupta, Saptarshi Roy, Reynold Panettieri Jr and Hydar Ali

    Citation: Respiratory Research 2018 19:1

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  50. Content type: Research

    SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However,...

    Authors: Zhilong Jiang, Zhihong Chen, Liyang Li, Wenjun Zhou and Lei Zhu

    Citation: Respiratory Research 2017 18:217

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