Skip to content

Advertisement

Articles

Page 5 of 48

  1. Content type: Research

    Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive ...

    Authors: Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki and Péter Engelmann

    Citation: Respiratory Research 2017 18:197

    Published on:

  2. Content type: Research

    Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodate...

    Authors: Marc Miravitlles, Gerard Urrutia, Alexander G. Mathioudakis and Julio Ancochea

    Citation: Respiratory Research 2017 18:196

    Published on:

  3. Content type: Research

    The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling...

    Authors: Shinkichi Ishikawa, Kanae Ishimori and Shigeaki Ito

    Citation: Respiratory Research 2017 18:195

    Published on:

  4. Content type: Research

    Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of cor...

    Authors: Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo and Kian Fan Chung

    Citation: Respiratory Research 2017 18:194

    Published on:

  5. Content type: Research

    Despite their growing popularity, the potential respiratory toxicity of electronic cigarettes (e-cigarettes) remains largely unknown. One potential aspect of e-cigarette toxicity is the effect of e-cigarette v...

    Authors: Rebecca J. Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya and Amir M. Farnoud

    Citation: Respiratory Research 2017 18:193

    Published on:

  6. Content type: Research

    Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsibl...

    Authors: Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq and Philippe Gosset

    Citation: Respiratory Research 2017 18:191

    Published on:

  7. Content type: Commentary

    Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more re...

    Authors: Ianthe Piscaer, Emiel F. M. Wouters, Cees Vermeer, Wim Janssens, Frits M. E. Franssen and Rob Janssen

    Citation: Respiratory Research 2017 18:189

    Published on:

  8. Content type: Letter to the Editor

    The main symptoms of patients with idiopathic pulmonary fibrosis (IPF) are cough and dyspnea. IPF leads to a restrictive lung disorder impacting daytime and nocturnal breathing patterns. In this pilot study we...

    Authors: Anke Schertel, Manuela Funke-Chambour, Thomas Geiser and Anne-Kathrin Brill

    Citation: Respiratory Research 2017 18:190

    Published on:

  9. Content type: Research

    The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and conse...

    Authors: Stephane Esnault, Ksenija Bernau, Elizabeth E. Torr, Yury A. Bochkov, Nizar N. Jarjour and Nathan Sandbo

    Citation: Respiratory Research 2017 18:188

    Published on:

  10. Content type: Research

    Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to respond to standard vasodilator therapy tar...

    Authors: Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel and Robbert J. Rottier

    Citation: Respiratory Research 2017 18:187

    Published on:

  11. Content type: Research

    Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of cope...

    Authors: Jacob A. Winther, Jon Brynildsen, Arne Didrik Høiseth, Heidi Strand, Ivar Følling, Geir Christensen, Ståle Nygård, Helge Røsjø and Torbjørn Omland

    Citation: Respiratory Research 2017 18:184

    Published on:

  12. Content type: Research

    Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, wh...

    Authors: Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva and Patricia Rieken Macedo Rocco

    Citation: Respiratory Research 2017 18:185

    Published on:

  13. Content type: Research

    Revefenacin is a once-daily long-acting muscarinic antagonist (LAMA) in clinical development for the treatment of patients with chronic obstructive pulmonary disease (COPD). In a dose-ranging study, nebulized ...

    Authors: Krishna K. Pudi, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Edward Kerwin

    Citation: Respiratory Research 2017 18:182

    Published on:

  14. Content type: Letter to the Editor

    Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the ...

    Authors: Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp…

    Citation: Respiratory Research 2017 18:181

    Published on:

  15. Content type: Research

    Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in...

    Authors: Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P. Comellas, Prescott Woodruff, Wanda O’Neal, Dawn L. DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J. Castaldi, Craig Hersh, Edwin K. Silverman, James D. Crapo, Katerina Kechris and Russell P. Bowler

    Citation: Respiratory Research 2017 18:180

    Published on:

  16. Content type: Research

    Bilirubin is a potent anti-oxidant and higher serum concentrations of bilirubin have been associated with better lung function, slower lung function decline, and lower incidence of chronic obstructive pulmonar...

    Authors: Kirstin E. Brown, Don D. Sin, Helen Voelker, John E. Connett, Dennis E. Niewoehner and Ken M. Kunisaki

    Citation: Respiratory Research 2017 18:179

    Published on:

  17. Content type: Research

    Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of th...

    Authors: Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang and Pau-Chung Chen

    Citation: Respiratory Research 2017 18:178

    Published on:

  18. Content type: Research

    Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome (ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-induced vascular injury. Recently, endothelial...

    Authors: Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi and James West

    Citation: Respiratory Research 2017 18:177

    Published on:

  19. Content type: Research

    Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate fact...

    Authors: Rosario Menéndez, Raúl Méndez, Eva Polverino, Edmundo Rosales-Mayor, Isabel Amara-Elori, Soledad Reyes, Tomás Posadas, Laia Fernández-Barat and Antoni Torres

    Citation: Respiratory Research 2017 18:176

    Published on:

  20. Content type: Research

    Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for cardiovascular (CV) disease, one of the most frequent causes of death in COPD patients. The goal of the present study was to evalu...

    Authors: Jorge Zagaceta, Gorka Bastarrika, Javier J. Zulueta, Inmaculada Colina, Ana B. Alcaide, Arantza Campo, Miguel Divo, Ciro Casanova, José M. Marin, Victor M. Pinto-Plata, Bartolome R. Celli and Juan P. de-Torres

    Citation: Respiratory Research 2017 18:175

    Published on:

  21. Content type: Research

    Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors N...

    Authors: Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma and Hong Ye

    Citation: Respiratory Research 2017 18:174

    Published on:

  22. Content type: Research

    Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway...

    Authors: S. Vamsee Raju, Lawrence Rasmussen, Peter A. Sloane, Li Ping Tang, Emily Falk Libby and Steven M. Rowe

    Citation: Respiratory Research 2017 18:173

    Published on:

  23. Content type: Research

    Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR...

    Authors: Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara and Yasuhiko Nishioka

    Citation: Respiratory Research 2017 18:172

    Published on:

  24. Content type: Research

    Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients w...

    Authors: Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A. Jörres, Timm Greulich, Claus F. Vogelmeier and Robert Bals

    Citation: Respiratory Research 2017 18:171

    Published on:

  25. Content type: Research

    Regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in idiopathic pulmonary fibrosis (IPF) is unclear. This study was designed to explore the role of T...

    Authors: Ziliang Hou, Qiao Ye, Meihua Qiu, Yu Hao, Junyan Han and Hui Zeng

    Citation: Respiratory Research 2017 18:170

    Published on:

  26. Content type: Research

    Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at dete...

    Authors: Eman A. Toraih, Mohammad H. Hussein, Essam Al Ageeli, Eman Riad, Nouran B. AbdAllah, Ghada M. Helal and Manal S. Fawzy

    Citation: Respiratory Research 2017 18:169

    Published on:

  27. Content type: Review

    Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have demonstrated that deficiency of ITSN-1s is a cruci...

    Authors: Niranjan Jeganathan, Dan Predescu and Sanda Predescu

    Citation: Respiratory Research 2017 18:168

    Published on:

  28. Content type: Review

    Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the va...

    Authors: Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei and Judit E. Pongracz

    Citation: Respiratory Research 2017 18:167

    Published on:

  29. Content type: Research

    Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical i...

    Authors: Xin Lv, Tao Wen, Jiong Song, Dong Xie, Liang Wu, Xuemei Jiang, Ping Jiang and Zongmei Wen

    Citation: Respiratory Research 2017 18:165

    Published on:

  30. Content type: Research

    Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS)...

    Authors: Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou and Jordan P. Metcalf

    Citation: Respiratory Research 2017 18:166

    Published on:

  31. Content type: Research

    Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...

    Authors: Solveig Tangedal, Marianne Aanerud, Rune Grønseth, Christine Drengenes, Harald G. Wiker, Per S. Bakke and Tomas M. Eagan

    Citation: Respiratory Research 2017 18:164

    Published on:

  32. Content type: Research

    Tracheal obstruction resulting from expiratory tracheal deformation has been associated with respiratory symptoms and severe airway exacerbations. In chronic obstructive pulmonary disease (COPD), acute exacerb...

    Authors: Paul Leong, Anne Tran, Jhanavi Rangaswamy, Laurence E. Ruane, Michael W. Fernando, Martin I. MacDonald, Kenneth K. Lau and Philip G. Bardin

    Citation: Respiratory Research 2017 18:163

    Published on:

  33. Content type: Research

    COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors.

    Authors: Andreas Horner, Joan B. Soriano, Milo A. Puhan, Michael Studnicka, Bernhard Kaiser, Lowie E. G. W. Vanfleteren, Louisa Gnatiuc, Peter Burney, Marc Miravitlles, Francisco García-Rio, Julio Ancochea, Ana M. Menezes, Rogelio Perez-Padilla, Maria Montes de Oca, Carlos A. Torres-Duque, Andres Caballero…

    Citation: Respiratory Research 2017 18:162

    Published on:

  34. Content type: Research

    Autoimmune serologies are often obtained in the initial evaluation of uncharacterized interstitial lung disease (ILD). Whether this practice is helpful in delineating connective-tissue disease related ILD (CTD...

    Authors: Mohammad Alsumrain, Federica De Giacomi, Shireen Mirza and Teng Moua

    Citation: Respiratory Research 2017 18:161

    Published on:

  35. Content type: Research

    Cigarette smoking has been associated with the risk of idiopathic pulmonary fibrosis (IPF). Certain comorbidities have been associated with reduced survival although some studies have indicated that current sm...

    Authors: Miia Kärkkäinen, Hannu-Pekka Kettunen, Hanna Nurmi, Tuomas Selander, Minna Purokivi and Riitta Kaarteenaho

    Citation: Respiratory Research 2017 18:160

    Published on:

  36. Content type: Research

    Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction.

    Authors: Emmanuel Briend, G. John Ferguson, Michiko Mori, Gautam Damera, Katherine Stephenson, Natasha A. Karp, Sanjay Sethi, Christine K. Ward, Matthew A. Sleeman, Jonas S. Erjefält and Donna K. Finch

    Citation: Respiratory Research 2017 18:159

    Published on:

  37. Content type: Erratum

    Authors: Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Citation: Respiratory Research 2017 18:158

    Published on:

    The original article was published in Respiratory Research 2017 18:8

  38. Content type: Research

    Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover stu...

    Authors: Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose and Ubaldo Martin

    Citation: Respiratory Research 2017 18:157

    Published on:

  39. Content type: Review

    Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the ...

    Authors: Brittany Salter, Cara Pray, Katherine Radford, James G. Martin and Parameswaran Nair

    Citation: Respiratory Research 2017 18:156

    Published on:

  40. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that th...

    Authors: Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu and Zhijun Jie

    Citation: Respiratory Research 2017 18:155

    Published on:

  41. Content type: Review

    Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over...

    Authors: Seyed M. Moosavi, Pavan Prabhala and Alaina J. Ammit

    Citation: Respiratory Research 2017 18:154

    Published on:

  42. Content type: Research

    Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice...

    Authors: Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf and Koustav Ganguly

    Citation: Respiratory Research 2017 18:152

    Published on:

  43. Content type: Research

    Interleukin-1 receptor 1 (IL-1R1) inhibition is a potential strategy for treating patients with chronic obstructive pulmonary disease (COPD). MEDI8968, a fully human monoclonal antibody, binds selectively to I...

    Authors: Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold and René van der Merwe

    Citation: Respiratory Research 2017 18:153

    Published on:

  44. Content type: Research

    Alveolar type 2 (AT2) cells play important roles in maintaining adult lung homeostasis. AT2 cells isolated from the lung have revealed the cell-specific functions of AT2 cells. Comprehensive molecular and tran...

    Authors: Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro and Toyohiro Hirai

    Citation: Respiratory Research 2017 18:150

    Published on:

  45. Content type: Review

    The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after l...

    Authors: Nicole E. Speck, Macé M. Schuurmans, Christian Benden, Cécile A. Robinson and Lars C. Huber

    Citation: Respiratory Research 2017 18:151

    Published on:

  46. Content type: Review

    Omics approaches are high-throughput unbiased technologies that provide snapshots of various aspects of biological systems and include: 1) genomics, the measure of DNA variation; 2) transcriptomics, the measur...

    Authors: Mengyuan Kan, Maya Shumyatcher and Blanca E. Himes

    Citation: Respiratory Research 2017 18:149

    Published on:

  47. Content type: Letter to the Editor

    The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the osc...

    Authors: Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee and Man Yong Han

    Citation: Respiratory Research 2017 18:148

    Published on:

2017 Journal Metrics

Advertisement