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  1. Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in the airways and subsequent respiratory infection. The recently approved triple therapy Elexacaftor–Tezacaftor–Ivacaftor (ETI) ha...

    Authors: Christian Martin, Douglas V. Guzior, Cely T. Gonzalez, Maxwell Okros, Jenna Mielke, Lienwil Padillo, Gabriel Querido, Marissa Gil, Ryan Thomas, Marc McClelland, Doug Conrad, Stefanie Widder and Robert A. Quinn
    Citation: Respiratory Research 2023 24:317
    Content type: Research Published on:

  2. Over the last ten years an increasing prevalence and incidence of non-tuberculous mycobacteria (NTM) has been reported among patients with cystic fibrosis (CF) Viviani (J Cyst Fibros, 15(5):619–623, 2016). NTM...

    Authors: Andrea Gramegna, Sofia Misuraca, Andrea Lombardi, Chiara Premuda, Ivan Barone, Margherita Ori, Francesco Amati, Mariangela Retucci, Erica Nazzari, Gianfranco Alicandro, Maurizio Ferrarese, Luigi Codecasa, Alessandra Bandera, Stefano Aliberti, Valeria Daccò and Francesco Blasi
    Citation: Respiratory Research 2023 24:316
    Content type: Review Published on:

  3. The two-way communications along the gut-lung axis influence the immune function in both gut and lung. However, the shared genetic characteristics of lung function with gastrointestinal tract (GIT) diseases re...

    Authors: Minghui Jiang, Xingjie Hao, Yi Jiang, Si Li, Chaolong Wang and Shanshan Cheng
    Citation: Respiratory Research 2023 24:315
    Content type: Research Published on:

  4. Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibr...

    Authors: Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson and Kevin K. Kim
    Citation: Respiratory Research 2023 24:314
    Content type: Research Published on:

  5. Sporadic studies have examined the impact of OSA on ACS patients by homocysteine (Hcy) level. This study attempted to comprehensively evaluate the effects of the interaction between Hcy and OSA on long-term ca...

    Authors: Xiuhuan Chen, Lei Zhen, Hui Ai, Bin Que, Jingyao Fan, Xiao Wang, Yan Yan, Siyi Li, Zekun Zhang, Yun Zhou, Wei Gong and Shaoping Nie
    Citation: Respiratory Research 2023 24:313
    Content type: Research Published on:

  7. Severe asthma and COPD exacerbations requiring hospitalization are linked to increased disease morbidity and healthcare costs. We sought to identify Electronic Health Record (EHR) features of severe asthma and...

    Authors: Kevin Lopez, Huan Li, Zachary Lipkin-Moore, Shannon Kay, Haseena Rajeevan, J. Lucian Davis, F. Perry Wilson, Carolyn L. Rochester and Jose L. Gomez
    Citation: Respiratory Research 2023 24:311
    Content type: Research Published on:

  8. Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. A large number of studies have shown that pulmonary vascular...

    Authors: Lei Ma, Yanxia Wang, Xiaoqian Li, Zefang Wang, Bo Zhang, Ying Luo, Yousheng Wu, Zhichao Li and Wen Niu
    Citation: Respiratory Research 2023 24:310
    Content type: Research Published on:

  9. Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease. α-defensins are ...

    Authors: Jungnam Lee, Naweed Mohammad, Yuanqing Lu, Regina Oshins, Alek Aranyos and Mark Brantly
    Citation: Respiratory Research 2023 24:309
    Content type: Research Published on:

  10. Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signal...

    Authors: Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman…
    Citation: Respiratory Research 2023 24:308
    Content type: Research Published on:

  11. Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates. Although lung transplantation is a life-saving treatment for selected patients with IL...

    Authors: Hyeon Hwa Kim, Ho Cheol Kim, Tae Sun Shim, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Geun Dong Lee, Dong Kwan Kim, Seung-Il Park and Sehoon Choi
    Citation: Respiratory Research 2023 24:307
    Content type: Research Published on:

  12. Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious respiratory diseases such as influenza. Our previous studies have shown tha...

    Authors: Shunwang Li, Xiangwu Ju, Qiang Liu, Yiwu Yan, Cong Zhang, Yuhao Qin, Xingyu Deng, Chang Li, Mingyao Tian, Yanli Zhang, Ningyi Jin and Chengyu Jiang
    Citation: Respiratory Research 2023 24:306
    Content type: Research Published on:

  13. Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizuma...

    Authors: Ayobami Akenroye, Tanawin Nopsopon, Laura Cho, Matthew Moll and Scott T. Weiss
    Citation: Respiratory Research 2023 24:305
    Content type: Research Published on:

  14. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical out...

    Authors: Anlin Feng, Yesenia Moreno Caro, Colin Gardner, Garrett Grischo, Ying Liang, Praveen D. Wickremasinghe, Michaela Polmann, Mrinalini Kala, Timothy Marlowe, Stephen M. Black, Kenneth S. Knox and Ting Wang
    Citation: Respiratory Research 2023 24:304
    Content type: Research Published on:

  15. Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immun...

    Authors: Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro and Peter G. Gibson
    Citation: Respiratory Research 2023 24:303
    Content type: Research Published on:

  16. Air pollution, weather, pollen, and influenza are typical aggravating factors for asthma. Previous studies have identified risk factors using regression-based and ensemble models. However, studies that conside...

    Authors: Hyemin Hwang, Jae-Hyuk Jang, Eunyoung Lee, Hae-Sim Park and Jae Young Lee
    Citation: Respiratory Research 2023 24:302
    Content type: Research Published on:

  17. It is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke extract (CSE). However, the mechanisms underlying th...

    Authors: Congping Li, Fei Chen, Liangfen Lin, Jiwei Li, Yamei Zheng and Qingyun Chen
    Citation: Respiratory Research 2023 24:301
    Content type: Research Published on:

  18. The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of lung-resident mesenchymal stem cells (LR-MSCs) has been identified as a critical sourc...

    Authors: Yi Lu, Zeyu Liu, Yunjiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang and Tao Ren
    Citation: Respiratory Research 2023 24:300
    Content type: Research Published on:

  19. Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM fro...

    Authors: Bin Chen, Ziyi Liu, Jinjuan Lu, Zhihao Li, Kaiming Kuang, Jiancheng Yang, Zengmao Wang, Yingli Sun, Bo Du, Lin Qi and Ming Li
    Citation: Respiratory Research 2023 24:299
    Content type: Research Published on:

  20. IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled fibrosis. Fibroblasts and t...

    Authors: Fama Thiam, Sakshi Phogat, Filsan Ahmed Abokor and Emmanuel Twumasi Osei
    Citation: Respiratory Research 2023 24:298
    Content type: Review Published on:

  21. Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung disease, is a leading cause of morbidity and mortality worldwide. Prolonged cigarette smoking (CS) that causes irreversible airway remo...

    Authors: Wensi Zhu, Linxiao Han, Yuanyuan Wu, Lin Tong, Ludan He, Qin Wang, Yu Yan, Ting Pan, Jie Shen, Yuanlin Song, Yao Shen, Qiaoliang Zhu and Jian Zhou
    Citation: Respiratory Research 2023 24:297
    Content type: Research Published on:

  22. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience acute exacerbations (AE), which result in severe lung damage...

    Authors: Xu Ye, Mingrui Zhang, Huimin Gu, Mengying Liu, Yichao Zhao, Yanchen Shi, Shufei Wu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang and Mengshu Cao
    Citation: Respiratory Research 2023 24:296
    Content type: Review Published on:

  24. Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe ...

    Authors: Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andréanne Côté, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou and Jamila Chakir
    Citation: Respiratory Research 2023 24:294
    Content type: Research Published on:

  25. People living with chronic obstructive pulmonary disease (COPD) have an increased risk of experiencing cardiovascular (CV) events, particularly after an exacerbation. Such CV burden is not yet known for incide...

    Authors: Karin M. A. Swart, Brenda N. Baak, Louise Lemmens, Fernie J. A. Penning-van Beest, Camilla Bengtsson, Muriel Lobier, Fabian Hoti, Dina Vojinovic, Lindy van Burk, Kirsty Rhodes, Edeltraut Garbe, Ron M. C. Herings, Clementine Nordon and Sami O. Simons
    Citation: Respiratory Research 2023 24:293
    Content type: Research Published on:

  26. COVID-19 infections are associated with accrued inflammatory responses which may result in cardiac injury. Immune response to infection appears different between men and women, suggesting that COVID-19 patient...

    Authors: Mathieu Jozwiak, Denis Doyen, Pierre Denormandie, Antoine Goury, Jonathan Marey, Frédéric Pène, Alain Cariou, Jean-Paul Mira, Jean Dellamonica and Lee S. Nguyen
    Citation: Respiratory Research 2023 24:292
    Content type: Research Published on:

  27. Several observational studies have found that physical inactivity and sedentary time are associated with idiopathic pulmonary fibrosis (IPF) risk. However, the causality between them still requires further inv...

    Authors: Wanyang Lei, Mei Yang, Ziyu Yuan, Runlin Feng, Xiao Kuang, Zhiqiang Liu, Zongqi Deng, Xianglin Hu and Wenlin Tai
    Citation: Respiratory Research 2023 24:291
    Content type: Research Published on:

  28. FOOTPRINTS® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation/lung tissue destruction and chronic obstructive pulmonary disease (COPD) severity and progress...

    Authors: James D. Crapo, Abhya Gupta, David A. Lynch, Alice M. Turner, Robert M. Mroz, Wim Janssens, Andrea Ludwig-Sengpiel, Harald Koegler, Anastasia Eleftheraki, Frank Risse and Claudia Diefenbach
    Citation: Respiratory Research 2023 24:290
    Content type: Research Published on:

  29. Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is associated with the malignant phenotypes of pulmonary vascular cells. Rece...

    Authors: Congke Zhao, Xiangyang Le, Mengqi Li, Yuanbo Hu, Xiaohui Li, Zhuo Chen, Gaoyun Hu, Liqing Hu and Qianbin Li
    Citation: Respiratory Research 2023 24:289
    Content type: Research Published on:

  30. We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung damage before. However, limited knowledge exists concerning the biological role of S100A8/A...

    Authors: Jiang Yu, Boying Zhao, Qiangzhong Pi, Guoxiang Zhou, Zhe Cheng, Can Qu, Xiaowen Wang, Lingwen Kong, Suxin Luo, Dingyuan Du and Yongzheng Guo
    Citation: Respiratory Research 2023 24:288
    Content type: Research Published on:

  31. Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) ...

    Authors: Rachel Z. Blumhagen, Jonathan S. Kurche, Carlyne D. Cool, Avram D. Walts, David Heinz, Tasha E. Fingerlin, Ivana V. Yang and David A. Schwartz
    Citation: Respiratory Research 2023 24:287
    Content type: Research Published on:

  33. Hospital-acquired and ventilator-associated-pneumonia (HAP/VAP) are one of the most prevalent health-care associated infections in the intensive care unit (ICU). Culture-independent methods were therefore deve...

    Authors: Morgane Heitz, Albrice Levrat, Vladimir Lazarevic, Olivier Barraud, Stéphane Bland, Emmanuelle Santiago-Allexant, Karen Louis, Jacques Schrenzel and Sébastien Hauser
    Citation: Respiratory Research 2023 24:285
    Content type: Research Published on:

  34. Bronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsupervised machine learning approach, we created BPD subclasses (e.g., endotypes) by clust...

    Authors: Alvaro G. Moreira, Tanima Arora, Shreyas Arya, Caitlyn Winter, Charles T. Valadie and Przemko Kwinta
    Citation: Respiratory Research 2023 24:284
    Content type: Research Published on:

  35. Multiple prolonged symptoms are observed in patients who recover from acute coronavirus disease 2019 (COVID-19), defined as long COVID. Cough and sputum are presented by patients with long COVID during the acu...

    Authors: Mayuko Watase, Jun Miyata, Hideki Terai, Keeya Sunata, Emiko Matsuyama, Takanori Asakura, Ho Namkoong, Katsunori Masaki, Kazuma Yagi, Keiko Ohgino, Shotaro Chubachi, Ichiro Kawada, Takao Mochimaru, Ryosuke Satomi, Yoshitaka Oyamada, Keigo Kobayashi…
    Citation: Respiratory Research 2023 24:283
    Content type: Research Published on:

  36. To build prediction models with radiomics features, clinical/conventional radiographic signs and combined scores for the discrimination of micropapillary or solid subtypes (high-risk subtypes) of lung adenocar...

    Authors: Zhe Wang, Ning Zhang, Junhong Liu and Junfeng Liu
    Citation: Respiratory Research 2023 24:282
    Content type: Research Published on:

  37. Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally sma...

    Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Ellen Caroline Toledo do Nascimento, Jôse Mara de Brito, Leila Antonangelo, Caroline Silvério Faria, Jhonatas Sirino Monteiro, João Carlos Setubal, João Renato Rebello Pinho, Roberta Verciano Pereira, Marilia Seelaender, Gabriela Salim de Castro, Joanna D. C. C. Lima, Renata Aparecida de Almeida Monteiro, Amaro Nunes Duarte-Neto, Paulo Hilário Nascimento Saldiva…
    Citation: Respiratory Research 2023 24:281
    Content type: Research Published on:

  38. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal disease with limited therapeutic options. The infiltration of monocytes and fibroblasts into the injured lungs is implicated in IPF. Enolase-1 (ENO1) is a...

    Authors: Wei-Ching Huang, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Mao-Lin Chen, Tung-Yueh Chuang, Xiu-Li Yang, Yu-Yau Chou, Chih-Hsin Liu, Nai-Yu Chen, Chun-Jen Chen and Ta-Tung Yuan
    Citation: Respiratory Research 2023 24:280
    Content type: Research Published on:

  39. Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking.

    Authors: Theodoros Karampitsakos, Apostolos Galaris, Serafeim Chrysikos, Ourania Papaioannou, Ioannis Vamvakaris, Ilianna Barbayianni, Paraskevi Kanellopoulou, Sofia Grammenoudi, Nektarios Anagnostopoulos, Grigoris Stratakos, Matthaios Katsaras, Fotios Sampsonas, Katerina Dimakou, Effrosyni D. Manali, Spyridon Papiris, Bochra Tourki…
    Citation: Respiratory Research 2023 24:279
    Content type: Research Published on:

  40. Several risk factors for Coronavirus-2019 (COVID-19) disease have been highlighted in clinical evidence. Among the various risk factors are advanced age, metabolic illness such as diabetes, heart disease, and ...

    Authors: Antonio Vitiello, Michela Sabbatucci, Andrea Silenzi, Annalisa Capuano, Francesco Rossi, Andrea Zovi, Francesco Blasi and Giovanni Rezza
    Citation: Respiratory Research 2023 24:278
    Content type: Review Published on:

  41. Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid peroxidation. The molecular mechanisms underlying ferroptosis regulation in non-small cell lung cancer (NSCLC) are poo...

    Authors: Guangyao Shan, Guoshu Bi, Guangyin Zhao, Jiaqi Liang, Yunyi Bian, Huan Zhang, Xing Jin, Zhengyang Hu, Guangyu Yao, Hong Fan and Cheng Zhan
    Citation: Respiratory Research 2023 24:277
    Content type: Research Published on:

  42. Lung cancer represents a significant public health issue in China, given its high incidence and mortality rates. Circular RNAs (circRNAs) have been recently proposed to participate in the development and progr...

    Authors: Jie Zhou, Peiwei Li, Xiaogang Zhao, Yuanhao Zhao, Junwen Luo, Yupeng Deng, Ning Jiang, Zhaohua Xiao, Wenhao Zhang, Yongjia Zhou, Jiangfeng Zhao, Peichao Li, Yuliang Li and Zhongxian Tian
    Citation: Respiratory Research 2023 24:276
    Content type: Research Published on:

  43. Objective cough frequency has been reported in several respiratory conditions but the amount that healthy individuals cough daily is unclear. Seventy-nine healthy volunteers (38 males, median [IQR] age 41y [IQ...

    Authors: Kimberley J. Holt and Jaclyn A. Smith
    Citation: Respiratory Research 2023 24:275
    Content type: Correspondence Published on:

  44. Balloon pulmonary angioplasty (BPA) has beneficial effects on pulmonary hemodynamics, exercise capacity, and quality of life (QOL) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Recent...

    Authors: Kazutoshi Hirose, Shun Minatsuki, Akihito Saito, Hiroki Yagi, Norifumi Takeda, Masaru Hatano and Issei Komuro
    Citation: Respiratory Research 2023 24:274
    Content type: Correspondence Published on:

  45. Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) genera...

    Authors: Valentine Mismetti, Xavier Delavenne, David Montani, Souad Bezzeghoud, Olivier Delezay, Sophie Hodin, David Launay, Sylvain Marchand-Adam, Hilario Nunes, Edouard Ollier, Martine Reynaud-Gaubert, Jean Pastre, Julie Traclet, Sébastien Quetant, Sabrina Zeghmar, Laurent Bertoletti…
    Citation: Respiratory Research 2023 24:273
    Content type: Research Published on:

  46. SARS-CoV-2, the agent responsible for the COVID-19 pandemic, enters cells through viral spike glycoprotein binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). Given the lack of effective ...

    Authors: Niayesh Razi, Weizhong Li, Maxinne A. Ignacio, Jeffrey M. Loube, Eva L. Agostino, Xiaoping Zhu, Margaret A. Scull and Jeffrey J. DeStefano
    Citation: Respiratory Research 2023 24:272
    Content type: Research Published on:

  47. Interstitial lung disease (ILD) may be difficult to distinguish from other respiratory diseases due to overlapping clinical presentation. Recognition of ILD is often late, causing delay which has been associat...

    Authors: Iris G. van der Sar, Marlies S. Wijsenbeek, Gert-Jan Braunstahl, Jason O. Loekabino, Anne-Marie C. Dingemans, Johannes C. C. M. In ‘t Veen and Catharina C. Moor
    Citation: Respiratory Research 2023 24:271
    Content type: Research Published on:

  48. Right heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently of the underlying disease. However, the process of RHF development and progression is not fu...

    Authors: Xiaohui Zeng, Ruiyue Zhao, Zhixiong Wu, Zhuoji Ma, Chunxian Cen, Shanshan Gao, Wanxian Hong, Yanrong Yao, Kexin Wen, Shangwei Ding, Jian Wang, Wenju Lu, Xinlu Wang and Tao Wang
    Citation: Respiratory Research 2023 24:270
    Content type: Research Published on:

  49. Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq, we found that asthmatic lungs display lower levels of Isthmin-1 (ISM1) ...

    Authors: Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y. W. Lam, Wupeng Liao, Yuansheng Yang, W. S. Fred Wong and Ruowen Ge
    Citation: Respiratory Research 2023 24:269
    Content type: Research Published on:

  50. Forced vital capacity (FVC) reflects respiratory health, but the long-term trend and heterogeneity in FVC of Chinese students were understudied.

    Authors: Siying Zhang, Lihong Wu, Yumei Zhong, Meirou Shao, Zhiyi Wei, Wenfeng Dong, Aiping Zhu, Fang-biao Tao and Xiulong Wu
    Citation: Respiratory Research 2023 24:268
    Content type: Research Published on:
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