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  1. Content type: Research

    Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

    Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps and Joanna Floros

    Citation: Respiratory Research 2018 19:23

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  2. Content type: Research

    Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

    Authors: Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya and Koichi Omori

    Citation: Respiratory Research 2018 19:22

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  3. Content type: Research

    Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unk...

    Authors: Ashraf Fawzy, Nirupama Putcha, Laura M. Paulin, Carrie P. Aaron, Wassim W. Labaki, MeiLan K. Han, Robert A. Wise, Richard E. Kanner, Russell P. Bowler, R. Graham Barr and Nadia N. Hansel

    Citation: Respiratory Research 2018 19:20

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  4. Content type: Research

    Abnormal apoptosis of lung endothelial cells has been observed in emphysematous lung tissue and has been suggested to be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease...

    Authors: Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen and Ping Chen

    Citation: Respiratory Research 2018 19:21

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  5. Content type: Research

    Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patie...

    Authors: Peter R. Bremner, Ruby Birk, Noushin Brealey, Afisi S. Ismaila, Chang-Qing Zhu and David A. Lipson

    Citation: Respiratory Research 2018 19:19

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  6. Content type: Review

    Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential ...

    Authors: Julien Dimastromatteo, Eric J. Charles and Victor E. Laubach

    Citation: Respiratory Research 2018 19:17

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  7. Content type: Research

    Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...

    Authors: Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi and Lena Uller

    Citation: Respiratory Research 2018 19:16

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  8. Content type: Research

    We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of long-acting bronchodilators on exercise capacity in COPD patients.

    Authors: Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi and Stefano Centanni

    Citation: Respiratory Research 2018 19:18

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    The Correction to this article has been published in Respiratory Research 2018 19:70

  9. Content type: Research

    Accumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution. Their small size facilitates dispersal and subsequent exposur...

    Authors: Angela M. Fonceca, Graeme R. Zosky, Elizabeth M. Bozanich, Erika N. Sutanto, Anthony Kicic, Paul S. McNamara, Darryl A. Knight, Peter D. Sly, Debra J. Turner and Stephen M. Stick

    Citation: Respiratory Research 2018 19:15

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  10. Content type: Research

    Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

    Authors: Mark D. Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E. Lipson, Todd W. Seeley and Peter E. Huber

    Citation: Respiratory Research 2018 19:14

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  11. Content type: Research

    Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael Silva O.

    Citation: Respiratory Research 2018 19:13

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    The Correction to this article has been published in Respiratory Research 2018 19:77

  12. Content type: Review

    Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guideline...

    Authors: Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi and Claus F. Vogelmeier

    Citation: Respiratory Research 2018 19:11

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  13. Content type: Research

    Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increase...

    Authors: Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson and Christer Janson

    Citation: Respiratory Research 2018 19:12

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  14. Content type: Review

    Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in han...

    Authors: Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington and Richard Dekhuijzen

    Citation: Respiratory Research 2018 19:10

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  15. Content type: Letter to the Editor

    Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its tr...

    Authors: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates and Ann B. Millar

    Citation: Respiratory Research 2018 19:9

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  16. Content type: Commentary

    While the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) at rest is known to be associated with prognosis in pulmonary arterial hypertension (PAH), it is unclear if the NT-proBNP response to exercis...

    Authors: J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair and T. M. Berghaus

    Citation: Respiratory Research 2018 19:8

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  17. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. Patients present loss of lung function, dyspnea and dry cough. Diagnosis requires compatible radiologic imaging and, in undeter...

    Authors: Barbara Rindlisbacher, Cornelia Schmid, Thomas Geiser, Cédric Bovet and Manuela Funke-Chambour

    Citation: Respiratory Research 2018 19:7

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  18. Content type: Research

    There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our obje...

    Authors: Theresa A. Laguna, Cynthia B. Williams, Myra G. Nunez, Cole Welchlin-Bradford, Catherine E. Moen, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2018 19:6

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  19. Content type: Research

    Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress t...

    Authors: Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song and Jue Pan

    Citation: Respiratory Research 2018 19:5

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  20. Content type: Research

    Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a...

    Authors: Yinna Wang, Alyssa C. Rezey, Ruping Wang and Dale D. Tang

    Citation: Respiratory Research 2018 19:4

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  21. Content type: Research

    Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from p...

    Authors: E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage and Zissis C. Chroneos

    Citation: Respiratory Research 2018 19:3

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  22. Content type: Research

    Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed t...

    Authors: Manish Bodas, Steven Mazur, Taehong Min and Neeraj Vij

    Citation: Respiratory Research 2018 19:2

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  23. Content type: Letter to the Editor

    Hemokinin-1 (HK-1) is a novel neuropeptide produced by human bronchial cells and macrophages and causes contraction of human bronchi ex vivo. It is also generated by antigen/IgE-activated murine mast cells (MC...

    Authors: Wichayapha Manorak, Chizobam Idahosa, Kshitij Gupta, Saptarshi Roy, Reynold Panettieri Jr and Hydar Ali

    Citation: Respiratory Research 2018 19:1

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  24. Content type: Research

    Exposure to ambient ozone (O3) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O3 to trigger asthma exacerbations are sti...

    Authors: Aihua Bao, Hong Yang, Jie Ji, Yuqin Chen, Wuping Bao, Feng Li, Min Zhang, Xin Zhou, Qiang Li and Suqin Ben

    Citation: Respiratory Research 2017 18:216

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  25. Content type: Research

    SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However,...

    Authors: Zhilong Jiang, Zhihong Chen, Liyang Li, Wenjun Zhou and Lei Zhu

    Citation: Respiratory Research 2017 18:217

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