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  1. Asthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs. Eosinophils, a type of immune cell, play a critica...

    Authors: Kunlu Shen, Mengyuan Zhang, Ruiheng Zhao, Yun Li, Chunxiao Li, Xin Hou, Bingqing Sun, Bowen Liu, Min Xiang and Jiangtao Lin
    Citation: Respiratory Research 2023 24:231
  2. Triple therapy is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite dual therapy. The optimal timing of triple therapy following an exacerbation of COPD ...

    Authors: Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey and David M. G. Halpin
    Citation: Respiratory Research 2023 24:229
  3. Authors: Stefania Lo Cicero, Germana Castelli, Giovanna Blaconà, Sabina Maria Bruno, Giovanni Sette, Riccardo Pigliucci, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Francesca Spadaro, Ruggero De Maria, Mauro Biffoni, Giuseppe Cimino, Felice Amato, Marco Lucarelli and Adriana Eramo
    Citation: Respiratory Research 2023 24:228

    The original article was published in Respiratory Research 2023 24:217

  4. Functional alveolar regeneration is essential for the restoration of normal lung homeostasis after acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Lung is a relatively quiescent organ a...

    Authors: Jianhui Sun, Huacai Zhang, Di Liu, Wenyi Liu, Juan Du, Dalin Wen, Luoxi Li, Anqiang Zhang, Jianxin Jiang and Ling Zeng
    Citation: Respiratory Research 2023 24:227
  5. Small airways disease plays a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and is a major cause of obstruction; therefore, it is a critical pharmacotherapy target. This study ev...

    Authors: Omar Usmani, Grace Li, Jan De Backer, Hosein Sadafi, Libo Wu and Jonathan Marshall
    Citation: Respiratory Research 2023 24:226
  6. Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in ...

    Authors: Meropi Karakioulaki, Caroline Maria Berkemeier, Ingmar Heijnen, Leticia Grize, Eleni Papakonstantinou, Antonis Goulas, Michael Tamm and Daiana Stolz
    Citation: Respiratory Research 2023 24:225
  7. Muscle loss is prevalent in chronic obstructive pulmonary disease (COPD). Prior studies evaluating musculoskeletal dysfunction in COPD have focused on individuals with baseline low muscle mass. Currently, ther...

    Authors: Richard H. Zou, S. Mehdi Nouraie, Chad Karoleski, Yingze Zhang, Frank C. Sciurba, Daniel E. Forman and Jessica Bon
    Citation: Respiratory Research 2023 24:224
  8. Achieving and maintaining a low-risk profile is associated with favorable outcome in pulmonary arterial hypertension (PAH). The effects of treatment on risk profile are variable among patients.

    Authors: Agustin R. Garcia, Isabel Blanco, Lluis Ramon, Jesús Pérez-Sagredo, Francisco J. Guerra-Ramos, Clara Martín-Ontiyuelo, Olga Tura-Ceide, Francisco Pastor-Pérez, Pilar Escribano-Subías and Joan A. Barberà
    Citation: Respiratory Research 2023 24:223
  9. Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic stra...

    Authors: Mingting Wu, Zhenyan Wang, Xiaoqian Shi, Danni Zan, Hong Chen, Shuqiao Yang, Fangping Ding, Liu Yang, Pingping Tan, Runlin Z. Ma, Jing Wang, Lishuang Ma, Yingmin Ma and Jiawei Jin
    Citation: Respiratory Research 2023 24:222
  10. Although asthma and chronic obstructive pulmonary disease (COPD) are two distinct chronic airway inflammatory diseases, they often co-exist in a patient and the condition is referred to as asthma-COPD overlap ...

    Authors: Surajit Dey, Wenying Lu, Greg Haug, Collin Chia, Josie Larby, Heinrich C. Weber, Archana Vijay Gaikwad, Prem Bhattarai, Affan Mahmood Shahzad, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen and Sukhwinder Singh Sohal
    Citation: Respiratory Research 2023 24:221
  11. Pulmonary arterial hypertension is a major cause of death in systemic lupus erythematosus, but there are no tools specialized for predicting survival in systemic lupus erythematosus-associated pulmonary arteri...

    Authors: Jingge Qu, Mengtao Li, Xiao Zhang, Miaojia Zhang, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Junyan Qian…
    Citation: Respiratory Research 2023 24:220
  12. Serum biomarkers in the evaluation of organ involvement and prognostic monitoring of sarcoidosis have not been determined. The purpose of this study was to identify common biomarkers that could be used to asse...

    Authors: Ying Zhou, Xianqiu Chen, Mengmeng Zhao, Elyse E. Lower and Robert P. Baughman
    Citation: Respiratory Research 2023 24:219
  13. Environmental co-exposure to allergen and traffic-related air pollution is common globally and contributes to the exacerbation of respiratory diseases. Individual responses to environmental insults remain vari...

    Authors: Andrew Robinson, Ryan D. Huff, Min Hyung Ryu and Chris Carlsten
    Citation: Respiratory Research 2023 24:218
  14. Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR-modulating drugs may overcome specific defects, such as the case of Trikafta, which is a c...

    Authors: Stefania Lo Cicero, Germana Castelli, Giovanna Blaconà, Sabina Maria Bruno, Giovanni Sette, Riccardo Pigliucci, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Francesca Spadaro, Ruggero De Maria, Mauro Biffoni, Giuseppe Cimino, Felice Amato, Marco Lucarelli and Adriana Eramo
    Citation: Respiratory Research 2023 24:217

    The Correction to this article has been published in Respiratory Research 2023 24:228

  15. Macrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the pathogenesis of asthma. However, it is unclear whethe...

    Authors: Jin Liu, Yuqian Chen, Huan Chen, Yan Wang, Danyang Li, Qianqian Zhang, Limin Chai, Yuanjie Qiu, Jia Zhang, Nirui Shen, Qingting Wang, Jian Wang and Manxiang Li
    Citation: Respiratory Research 2023 24:216
  16. X-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conv...

    Authors: Trishul Siddharthan, Kyle Grealis, Jason P. Kirkness, Tamás Ötvös, Darko Stefanovski, Alex Tombleson, Molly Dalzell, Ernesto Gonzalez, Kinjal Bhatt Nakrani, David Wenger, Michael G. Lester, Bradley W. Richmond, Andreas Fouras and Naresh M. Punjabi
    Citation: Respiratory Research 2023 24:215
  17. Idiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor prognosis, and a paucity of efficacious treatment options. Dexmedetomi...

    Authors: Xiaofan Lai, Yingying Lin, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang and Wenqi Huang
    Citation: Respiratory Research 2023 24:214
  18. The airway epithelium is composed of diverse cell types with specialized functions that mediate homeostasis and protect against respiratory pathogens. Human airway epithelial (HAE) cultures at air–liquid inter...

    Authors: Rachel A. Prescott, Alec P. Pankow, Maren de Vries, Keaton M. Crosse, Roosheel S. Patel, Mark Alu, Cynthia Loomis, Victor Torres, Sergei Koralov, Ellie Ivanova, Meike Dittmann and Brad R. Rosenberg
    Citation: Respiratory Research 2023 24:213
  19. Previous studies have shown that IL-25 levels are increased in patients with asthma with fixed airflow limitation (FAL). However, the mechanism by which IL-25 contributes to airway remodeling and FAL remains u...

    Authors: Xiujuan Yao, Qinglin Chen, Xiangdong Wang, Xiaofang Liu and Luo Zhang
    Citation: Respiratory Research 2023 24:212
  20. Pulmonary fibrosis is a progressive disease characterized by lung remodeling due to excessive deposition of extracellular matrix. Although the etiology remains unknown, aberrant angiogenesis and inflammation p...

    Authors: Laura Cucinotta, Deborah Mannino, Giovanna Casili, Alberto Repici, Lelio Crupi, Irene Paterniti, Emanuela Esposito and Michela Campolo
    Citation: Respiratory Research 2023 24:211
  21. Authors: Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata and Md Alfazal Khan
    Citation: Respiratory Research 2023 24:210

    The original article was published in Respiratory Research 2021 22:35

  22. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterised by decline in lung function. We evaluated trajectories of forced vital capacity (FVC) and diffusing capaci...

    Authors: Megan L Neely, Anne S Hellkamp, Shaun Bender, Jamie L Todd, Timothy Liesching, Tracy R Luckhardt, Justin M Oldham, Rishi Raj, Eric S White and Scott M Palmer
    Citation: Respiratory Research 2023 24:209
  23. Non-invasive ventilation (NIV) is an evidence-based treatment for acute respiratory failure in chronic obstructive pulmonary disease (COPD). However, suboptimal application of NIV in clinical practice, possibl...

    Authors: Judith Elshof, Judith M. Vonk, Anouschka van der Pouw, Cella van Dijk, Petra Vos, Huib A.M. Kerstjens, Peter J. Wijkstra and Marieke L. Duiverman
    Citation: Respiratory Research 2023 24:208
  24. Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated with rhinovirus (RV) infections. Despite these associations, the path...

    Authors: Ying Wang, Dennis K. Ninaber, Alen Faiz, Abraham C. van der Linden, Annemarie van Schadewijk, René Lutter, Pieter S. Hiemstra, Anne M. van der Does and Abilash Ravi
    Citation: Respiratory Research 2023 24:207
  25. Due to the high risk of COVID-19 patients developing thrombosis in the circulating blood, atherosclerosis, and myocardial infarction, it is necessary to study the lipidome of erythrocytes. Specifically, we exa...

    Authors: Alaa Khedr, Maan T. Khayat, Ahdab N. Khayyat, Hany Z. Asfour, Rahmah A. Alsilmi and Ahmed K. Kammoun
    Citation: Respiratory Research 2023 24:206
  26. Rhinovirus (RV) infection of airway epithelial cells triggers asthma exacerbations, during which airway smooth muscle (ASM) excessively contracts. Due to ASM contraction, airway epithelial cells become mechani...

    Authors: Alane Blythe C. Dy, Jason Girkin, Antonella Marrocco, Adam Collison, Chimwemwe Mwase, Michael J. O’Sullivan, Thien-Khoi N. Phung, Joerg Mattes, Cynthia Koziol-White, James E. Gern, Yury A. Bochkov, Nathan W. Bartlett and Jin-Ah Park
    Citation: Respiratory Research 2023 24:205
  27. Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. The aim of this study was to inve...

    Authors: Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang…
    Citation: Respiratory Research 2023 24:204
  28. A growing body of evidence suggests that use of race terms in spirometry reference equations underestimates disease burden in Black populations, which may lead to disparities in pulmonary disease outcomes. Dat...

    Authors: Allison J. Burbank, Claire E. Atkinson, Andre E. Espaillat, Stephen A. Schworer, Katherine Mills, Jennifer Rooney, Ceila E. Loughlin, Wanda Phipatanakul and Michelle L. Hernandez
    Citation: Respiratory Research 2023 24:203
  29. Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography is a commonly used tool for evaluating the risk hierarchy of PH. However, few studies have explored the dy...

    Authors: Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu…
    Citation: Respiratory Research 2023 24:202
  30. Alveolar macrophages (AMs) and AM-produced matrix metalloprotease (MMP)-12 are known to play critical roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). The apoptosis inhibitor of the m...

    Authors: Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura and Satoshi Konno
    Citation: Respiratory Research 2023 24:201
  31. Data from clinical trials of lumacaftor-ivacaftor (LUM-IVA) demonstrate improvements in lung clearance index (LCI) but not in FEV1 in children with Cystic Fibrosis (CF) aged 6–11 years and homozygous for the Phe5...

    Authors: Paul McNally, Barry Linnane, Michael Williamson, Basil Elnazir, Christopher Short, Clare Saunders, Laura Kirwan, Rea David, Mariette P. C. Kemner-Van de Corput, Harm A.W.M. Tiddens, Jane C Davies and Des W Cox
    Citation: Respiratory Research 2023 24:199
  32. The primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if symptoms such as airway hyperreactivity (AHR) and increased airway smooth mus...

    Authors: Elizabeth L. Kramer, Kristin M. Hudock, Cynthia R. Davidson and John P. Clancy
    Citation: Respiratory Research 2023 24:198
  33. Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and ...

    Authors: Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage-Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko and Efrat Eliyahu
    Citation: Respiratory Research 2023 24:197
  34. Coronavirus disease 2019 (COVID-19) patients can develop pulmonary fibrosis (PF), which is associated with impaired outcome. We assessed specific leukocytic transcriptome profiles associated with PF and the in...

    Authors: Emma J. Kooistra, Kilian Dahm, Antonius E. van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L. Smeets, Sjef van der Velde, Maarten J. W. van den Berg, Johannes G. van der Hoeven, Anna C. Aschenbrenner, Joachim L. Schultze, Thomas Ulas, Matthijs Kox and Peter Pickkers
    Citation: Respiratory Research 2023 24:196
  35. Acute pulmonary embolism (APE) is a hazardous disorder with a high mortality. Combination of clinical, radiological, and serological parameters can improve risk stratification of APE. Most of the proposed comb...

    Authors: Alexey Surov, Maximilian Thormann, Caroline Bär, Andreas Wienke and Jan Borggrefe
    Citation: Respiratory Research 2023 24:195
  36. Oxidative stress and persistent airway inflammation are thought to be important contributors to the development of chronic obstructive pulmonary disease (COPD). This review summarizes the evidence for targetin...

    Authors: Mario Cazzola, Clive P. Page, Jadwiga A. Wedzicha, Bartolome R. Celli, Antonio Anzueto and Maria Gabriella Matera
    Citation: Respiratory Research 2023 24:194
  37. Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal...

    Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort and Ian M. Adcock
    Citation: Respiratory Research 2023 24:193
  38. Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic po...

    Authors: Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu…
    Citation: Respiratory Research 2023 24:192
  39. Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urina...

    Authors: Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom and Sailesh Kotecha
    Citation: Respiratory Research 2023 24:191
  40. Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in ...

    Authors: Arianne K. Baldomero, David M. MacDonald, Adam Kaplan, Eric Lock, Michael H. Cho, Russell Bowler, Lucas Gillenwater, Ken M. Kunisaki and Chris H. Wendt
    Citation: Respiratory Research 2023 24:190
  41. Accumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains sparsely studied. We tested effects of Chronic Intermittent Hypoxia (CIH)...

    Authors: Mihaela Teodorescu, Ruolin Song, Jacqueline A. Brinkman and Ronald L. Sorkness
    Citation: Respiratory Research 2023 24:189
  42. Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of ad...

    Authors: Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig and György Haskó
    Citation: Respiratory Research 2023 24:186
  43. Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious and prolonged respiratory complications among survivors. Given that...

    Authors: Eugene Becker Jr., Maroof Husain, Nathaniel Bone, Samuel Smith, Peter Morris and Jaroslaw W. Zmijewski
    Citation: Respiratory Research 2023 24:185
  44. Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving ...

    Authors: Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland and Anthony Bosco
    Citation: Respiratory Research 2023 24:184
  45. The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about th...

    Authors: Rajesh Shigdel, Ane Johannessen, Huang Lin, Shyamal Peddada, Francisco Gómez Real, Tamar Ringel-Kulka, Cecilie Svanes and Randi Jacobsen Bertelsen
    Citation: Respiratory Research 2023 24:183
  46. Alveolar epithelial barrier is a potential therapeutic target for acute respiratory distress syndrome (ARDS). However, an effective intervention against alveolar epithelial barrier has not been developed. Here...

    Authors: Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng and Liang Dong
    Citation: Respiratory Research 2023 24:182

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