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  1. Content type: Research

    Alveolar type 2 (AT2) cells play important roles in maintaining adult lung homeostasis. AT2 cells isolated from the lung have revealed the cell-specific functions of AT2 cells. Comprehensive molecular and tran...

    Authors: Koichi Hasegawa, Atsuyasu Sato, Kazuya Tanimura, Kiyoshi Uemasu, Yoko Hamakawa, Yoshinori Fuseya, Susumu Sato, Shigeo Muro and Toyohiro Hirai

    Citation: Respiratory Research 2017 18:150

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  2. Content type: Research

    Diffuse alveolar damage (DAD), which is the histological surrogate for acute respiratory distress syndrome (ARDS), has a multifactorial aetiology. Therefore it is possible that the immunopathology differs amon...

    Authors: Monique Buttignol, Ruy Camargo Pires-Neto, Renata Calciolari Rossi e Silva, Marina Ballarin Albino, Marisa Dolhnikoff and Thais Mauad

    Citation: Respiratory Research 2017 18:147

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  3. Content type: Review

    Omics approaches are high-throughput unbiased technologies that provide snapshots of various aspects of biological systems and include: 1) genomics, the measure of DNA variation; 2) transcriptomics, the measur...

    Authors: Mengyuan Kan, Maya Shumyatcher and Blanca E. Himes

    Citation: Respiratory Research 2017 18:149

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  4. Content type: Letter to the Editor

    The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the osc...

    Authors: Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee and Man Yong Han

    Citation: Respiratory Research 2017 18:148

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  5. Content type: Research

    Methacholine dose-response curves illustrate pharmacologic bronchoprotection against methacholine-induced airway hyperresponsiveness and can be used to quantitate changes in airway sensitivity (position), reac...

    Authors: Christianne M. Blais, Beth E. Davis and Donald W. Cockcroft

    Citation: Respiratory Research 2017 18:146

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  6. Content type: Research

    Muscarinic-receptor antagonists and β-adrenoceptor agonists are used, alone or in combination, as first-line treatment for chronic obstructive pulmonary disease. Both drugs decrease airway smooth muscle tone b...

    Authors: Michele Baroffio, Giovanni Barisione and Vito Brusasco

    Citation: Respiratory Research 2017 18:145

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  7. Content type: Research

    Ambient particulate matter exposure has been shown to increase the risks of respiratory diseases. However, the role of the lung microbiome and the immune response to inhaled particulate matter are largely unex...

    Authors: Naijian Li, Fang He, Baoling Liao, Yuming Zhou, Bing Li and Pixin Ran

    Citation: Respiratory Research 2017 18:143

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  8. Content type: Research

    Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respi...

    Authors: T. B. M. Tilanus, J. T. Groothuis, J. M. C. TenBroek-Pastoor, T. B. Feuth, Y. F. Heijdra, J. P. L. Slenders, J. Doorduin, B. G. Van Engelen, M. J. Kampelmacher and J. Raaphorst

    Citation: Respiratory Research 2017 18:144

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  9. Content type: Research

    Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based on a-priori knowledg...

    Authors: K. de Jong, J.M. Vonk, M. Imboden, L. Lahousse, A. Hofman, G.G. Brusselle, N.M. Probst-Hensch, D.S. Postma and H.M. Boezen

    Citation: Respiratory Research 2017 18:142

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  10. Content type: Research

    Dual bronchodilation combining a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by the Global Initiative for Chronic Obstructive Lung...

    Authors: Claus F. Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M. Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens and Konstantinos Kostikas

    Citation: Respiratory Research 2017 18:140

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  11. Content type: Research

    Interstitial lung disease (ILD) can be a severe extra-articular disease manifestation in Rheumatoid Arthritis (RA). A potential role of fibrocytes in RA associated ILD (RA-ILD) has not previously been describe...

    Authors: Søren Andreas Just, Hanne Lindegaard, Eva Kildall Hejbøl, Jesper Rømhild Davidsen, Niels Bjerring, Søren Werner Karlskov Hansen, Henrik Daa Schrøder, Inger Marie Jensen Hansen, Torben Barington and Christian Nielsen

    Citation: Respiratory Research 2017 18:141

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  12. Content type: Research

    The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary ...

    Authors: Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner…

    Citation: Respiratory Research 2017 18:139

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  13. Content type: Research

    Mesenchymal stem cells (MSCs) attenuate lung injury in experimental models of bronchopulmonary dysplasia (BPD). Stromal derived factor-1 (SDF-1), a chemokine secreted by MSCs, modulates angiogenesis and stem c...

    Authors: Joel Reiter, Shelley Drummond, Ibrahim Sammour, Jian Huang, Victoria Florea, Polliana Dornas, Joshua M. Hare, Claudia O. Rodrigues and Karen C. Young

    Citation: Respiratory Research 2017 18:137

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  14. Content type: Research

    Various factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current envi...

    Authors: Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak and Holger Schulz

    Citation: Respiratory Research 2017 18:138

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  15. Content type: Research

    Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lun...

    Authors: Ahmed R. Alsuwaidi, Junu A. George, Saeeda Almarzooqi, Stacey M. Hartwig, Steven M. Varga and Abdul-Kader Souid

    Citation: Respiratory Research 2017 18:136

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  16. Content type: Research

    Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstr...

    Authors: Matthieu Hein, Jean-Pol Lanquart, Gwénolé Loas, Philippe Hubain and Paul Linkowski

    Citation: Respiratory Research 2017 18:135

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  17. Content type: Research

    Bronchial thermoplasty (BT) is an emerging bronchoscopic intervention for the treatment of severe asthma. The predictive factors for clinical response to BT are unknown. We examined the relationship between th...

    Authors: David Langton, Joy Sha, Alvin Ing, David Fielding, Francis Thien and Virginia Plummer

    Citation: Respiratory Research 2017 18:134

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  18. Content type: Letter to the Editor

    The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of inflammat...

    Authors: Sophie F. Demarche, Florence N. Schleich, Virginie A. Paulus, Monique A. Henket, Thierry J. Van Hees and Renaud E. Louis

    Citation: Respiratory Research 2017 18:133

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  19. Content type: Research

    Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provi...

    Authors: Phuong-Uyen C. Dinh, Jhon Cores, M. Taylor Hensley, Adam C. Vandergriff, Junnan Tang, Tyler A. Allen, Thomas G. Caranasos, Kenneth B. Adler, Leonard J. Lobo and Ke Cheng

    Citation: Respiratory Research 2017 18:132

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  20. Content type: Research

    Obstructive sleep apnea is characterized by intermittent hypoxia and hypercapnia. CO2 production, transport and elimination are influenced by the carbonic anhydrase enzyme. We hypothesized that elevated standard ...

    Authors: Davoud Eskandari, Ding Zou, Ludger Grote, Hartmut Schneider, Thomas Penzel and Jan Hedner

    Citation: Respiratory Research 2017 18:130

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  21. Content type: Research

    Azithromycin, an antibiotic used for multiple infectious disorders, exhibits anti-inflammatory effects, but the molecular basis for this activity is not well characterized. Azithromycin inhibits IL-1β-mediated...

    Authors: Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer and Rama K. Mallampalli

    Citation: Respiratory Research 2017 18:131

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  22. Content type: Research

    An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in ute...

    Authors: Alexandra Noël, Rui Xiao, Zakia Perveen, Hasan Zaman, Viviana Le Donne and Arthur Penn

    Citation: Respiratory Research 2017 18:104

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  23. Content type: Research

    Tuberculosis (TB) is one of the most common infectious diseases worldwide. During active tuberculosis, T helper (Th) 17 cells are decreased, however the association with inhibitory immune regulation is unclear.

    Authors: Chin-Chung Shu, Ming-Fang Wu, Jann-Yuan Wang, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang and Chong-Jen Yu

    Citation: Respiratory Research 2017 18:128

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  24. Content type: Research

    Treatment of severe asthma may include high dose systemic-steroid therapy which is associated with substantial additional morbidity. This study estimates the additional healthcare costs associated with steroid...

    Authors: L. E. Barry, J. Sweeney, C. O’Neill, D. Price and L. G. Heaney

    Citation: Respiratory Research 2017 18:129

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  25. Content type: Research

    Pulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes ...

    Authors: Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan and Xiaolu Li

    Citation: Respiratory Research 2017 18:127

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