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  1. Content type: Research

    The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis of asthma. House dust mite (HDM), one of the most important allergens, could increase the airway epi...

    Authors: Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li and Shao-xi Cai

    Citation: Respiratory Research 2017 18:111

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  2. Content type: Review

    Alpha-1 antitrypsin deficiency (AATD) is a common hereditary disorder caused by mutations in the SERPINA1 gene, which encodes alpha-1 antitrypsin (AAT; also known as alpha 1-proteinase inhibitor, A1-PI). An impor...

    Authors: Franck F. Rahaghi and Marc Miravitlles

    Citation: Respiratory Research 2017 18:105

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  3. Content type: Research

    Helicobacter pylori (HP) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Azithromycin (AZ) is act...

    Authors: Seung Won Ra, Marc A. Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Shawn D. Aaron, Robert M. Reed, S. F. Paul Man…

    Citation: Respiratory Research 2017 18:109

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  4. Content type: Research

    Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help to identif...

    Authors: Jaume Trapé, Francesc Sant, Josefina Franquesa, Jesús Montesinos, Anna Arnau, Maria Sala, Oscar Bernadich, Esperanza Martín, Damià Perich, Concha Pérez, Joan Lopez, Sandra Ros, Enrique Esteve, Rafael Pérez, Jordi Aligué, Gabriel Gurt…

    Citation: Respiratory Research 2017 18:103

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  5. Content type: Research

    Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The Sonic hedgehog (SHH) pathway is involved in vascular physiology. We sought to establish whether the SHH pathway has a...

    Authors: Priscilla Henno, Stanislas Grassin-Delyle, Emeline Belle, Marion Brollo, Emmanuel Naline, Edouard Sage, Philippe Devillier and Dominique Israël-Biet

    Citation: Respiratory Research 2017 18:102

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  6. Content type: Research

    In acute respiratory respiratory distress syndrome (ARDS) a sustained mismatch of alveolar ventilation and perfusion (VA/Q) impairs the pulmonary gas exchange. Measurement of endexpiratory lung volume (EELV) by m...

    Authors: Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David and Erik K. Hartmann

    Citation: Respiratory Research 2017 18:101

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  7. Content type: Research

    COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical manifestations of COPD and this classifica...

    Authors: Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers and Leo Koenderman

    Citation: Respiratory Research 2017 18:100

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  8. Content type: Research

    Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The...

    Authors: Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito and Peter J. Barnes

    Citation: Respiratory Research 2017 18:99

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  9. Content type: Research

    We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis ...

    Authors: Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko…

    Citation: Respiratory Research 2017 18:97

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  10. Content type: Review

    Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a cl...

    Authors: Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan and Bruce R. Thompson

    Citation: Respiratory Research 2017 18:96

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  11. Content type: Research

    The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world’s widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the i...

    Authors: Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall and David W. Parsons

    Citation: Respiratory Research 2017 18:95

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  12. Content type: Research

    Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and ado...

    Authors: Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna and Mika J. Mäkelä

    Citation: Respiratory Research 2017 18:94

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  13. Content type: Research

    Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying ...

    Authors: Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan and Jeremy A. Hirota

    Citation: Respiratory Research 2017 18:92

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  14. Content type: Research

    The rising incidence of pulmonary Mycobacterium avium-intracellulare complex (MAI) infection is unexplained but parallels the growing world-wide epidemic of allergic disease. We hypothesized an association betwee...

    Authors: Paul E. Pfeffer, Susan Hopkins, Ian Cropley, David M. Lowe and Marc Lipman

    Citation: Respiratory Research 2017 18:93

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  15. Content type: Research

    Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA me...

    Authors: Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang and Changfu Hao

    Citation: Respiratory Research 2017 18:91

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  16. Content type: Research

    Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of...

    Authors: Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo and Dave Singh

    Citation: Respiratory Research 2017 18:90

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  17. Content type: Research

    In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved th...

    Authors: Marta Camprubí–Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch and Antonio Artigas

    Citation: Respiratory Research 2017 18:89

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  18. Content type: Research

    The pulmonary neuroepithelial body (NEB) microenvironment (ME) consists of innervated cell clusters that occur sparsely distributed in the airway epithelium, an organization that has so far hampered reliable s...

    Authors: Line Verckist, Robrecht Lembrechts, Sofie Thys, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns and Dirk Adriaensen

    Citation: Respiratory Research 2017 18:87

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  19. Content type: Research

    Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bact...

    Authors: Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Citation: Respiratory Research 2017 18:88

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  20. Content type: Research

    Reducing rescue medication use is a guideline-defined goal of asthma treatment, however, little is known about the validity of rescue medicine use as a marker of symptoms in chronic obstructive pulmonary disea...

    Authors: Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya and Paul W. Jones

    Citation: Respiratory Research 2017 18:86

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  21. Content type: Research

    Pulmonary hypertension (PH) associated with lung disease has the worst prognosis of all types of PH. Pulmonary arterial vasculopathy is an early event in the natural history of chronic obstructive pulmonary di...

    Authors: Enric Domingo, Juan C. Grignola, Rio Aguilar, Manuel López Messeguer and Antonio Roman

    Citation: Respiratory Research 2017 18:85

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  22. Content type: Research

    The Rhinovirus C (RV-C), first identified in 2006, produce high symptom burdens in children and asthmatics, however, their primary target host cell in the airways remains unknown. Our primary hypotheses were t...

    Authors: Theodor F. Griggs, Yury A. Bochkov, Sarmila Basnet, Thomas R. Pasic, Rebecca A. Brockman-Schneider, Ann C. Palmenberg and James E. Gern

    Citation: Respiratory Research 2017 18:84

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  23. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is associated with several extra-pulmonary effects of which skeletal muscle wasting is one of the most common and contributes to reduced quality of life, increased ...

    Authors: Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos and Roberto A. Rabinovich

    Citation: Respiratory Research 2017 18:81

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