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  1. Asthma was originally described as an inflammatory disease that predominantly involves the central airways. Pathological and physiological evidence reported during the past few years suggests that the inflamma...

    Authors: Meri K Tulic, Pota Christodoulopoulos and Qutayba Hamid
    Citation: Respiratory Research 2001 2:333
  2. Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been ...

    Authors: Harald Renz
    Citation: Respiratory Research 2001 2:265
  3. The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tac...

    Authors: R Stokes Peebles Jr and Barney S Graham
    Citation: Respiratory Research 2001 2:245
  4. The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105→Val105 substitution are associated with the asthma pheno...

    Authors: Anja Hemmingsen, Anthony A Fryer, Michael Hepple, Richard C Strange and Monica A Spiteri
    Citation: Respiratory Research 2001 2:255
  5. Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve activity can be subclassified into compounds that...

    Authors: Bradley J Undem and Michael J Carr
    Citation: Respiratory Research 2001 2:234
  6. Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertens...

    Authors: Mark W Geraci, Bifeng Gao, Yasushi Hoshikawa, Michael E Yeager, Rubin M Tuder and Norbert F Voelkel
    Citation: Respiratory Research 2001 2:210
  7. The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmon...

    Authors: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget and Norbert Verbeke
    Citation: Respiratory Research 2001 2:198
  8. X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency caused by disruption of the Bruton's tyrosine kinase (BTK) gene. Typical XLA patients suffer recurrent and severe bacterial infections in childhood.

    Authors: Kazuhiro Usui, Yoji Sasahara, Ryushi Tazawa, Koichi Hagiwara, Satoshi Tsukada, Toshio Miyawaki, Shigeru Tsuchiya and Toshihiro Nukiwa
    Citation: Respiratory Research 2001 2:188
  9. The hygiene hypothesis, as originally proposed, postulated an inverse relation between the incidence of infectious diseases in early life and the subsequent development of allergies and asthma. New evidence fr...

    Authors: Fernando D Martinez
    Citation: Respiratory Research 2001 2:129
  10. The availability of molecular tools to carry out genotyping has led to a flurry of association studies between specific genes and clinical indices of disease or disease susceptibility. Human studies, for the m...

    Authors: Mitchell L Drumm
    Citation: Respiratory Research 2001 2:125

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