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  1. The most common pathologic form of pulmonary fibrosis arises from excessive deposition of extracellular matrix proteins such as collagen. The 47 kDa heat shock protein 47 (HSP47) is a collagen-specific molecul...

    Authors: Satoshi Hagiwara, Hideo Iwasaka, Shigekiyo Matsumoto and Takayuki Noguchi
    Citation: Respiratory Research 2007 8:37
  2. Heparin has been shown to modify fundamental biologic processes ranging from blood coagulation and cell proliferation to fibrogenesis and asthma. The goal of this study was to identify specific or broad biolog...

    Authors: Amir A Gabr, Mathew Reed, Donna R Newman, Jan Pohl, Jody Khosla and Philip L Sannes
    Citation: Respiratory Research 2007 8:36
  3. Antidepressants are heavily prescribed drugs and have been shown to affect inflammatory signals. We examined whether these have anti-inflammatory properties in animal models of septic shock and allergic asthma...

    Authors: Caroline Roumestan, Alain Michel, Florence Bichon, Karine Portet, Maëlle Detoc, Corinne Henriquet, Dany Jaffuel and Marc Mathieu
    Citation: Respiratory Research 2007 8:35
  4. Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes ...

    Authors: Jennifer L Ingram, Aurita Antao-Menezes, Elizabeth A Turpin, Duncan G Wallace, James B Mangum, Linda J Pluta, Russell S Thomas and James C Bonner
    Citation: Respiratory Research 2007 8:34
  5. In the diagnosis of early-stage lung cancer photosensitizer-enhanced fluorescence bronchoscopy with inhaled 5-aminolevolinic acid (5-ALA) increases sensitivity when compared to white-light bronchoscopy. This i...

    Authors: Hubert Hautmann, Josef P Pichler, Herbert Stepp, Reinhold Baumgartner, Fernando Gamarra and Rudolf M Huber
    Citation: Respiratory Research 2007 8:33
  6. Recently, it has been shown that increasing body mass index (BMI) in asthma is associated with reduced exhaled NO. Our objective in this study was to determine if the BMI-related changes in exhaled NO differ a...

    Authors: Sushma Komakula, Sumita Khatri, Joel Mermis, Samira Savill, Shireen Haque, Mauricio Rojas, LouAnn Brown, Gerald W Teague and Fernando Holguin
    Citation: Respiratory Research 2007 8:32
  7. Proteinase-activated receptors (PARs; PAR1–4) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases inclu...

    Authors: Seijitsu Ando, Hitomi Otani, Yasuhiro Yagi, Kenzo Kawai, Hiromasa Araki, Shirou Fukuhara and Chiyoko Inagaki
    Citation: Respiratory Research 2007 8:31
  8. For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic revie...

    Authors: Milo A Puhan, Daniela Vollenweider, Tsogyal Latshang, Johann Steurer and Claudia Steurer-Stey
    Citation: Respiratory Research 2007 8:30
  9. Interleukin 1 beta (IL-1β) is found in bronchoalveolar lavage fluids from asthmatic patients and plays an important role in normal immunoregulatory processes but also in pathophysiological inflammatory respons...

    Authors: Yaping Zhang, Lars-Olaf Cardell and Mikael Adner
    Citation: Respiratory Research 2007 8:29
  10. Nitric oxide (NO) is generally increased during inflammatory airway diseases. This increased NO stimulates the secretion of mucin from the goblet cell and submucosal glands but the mechanism is still unknown p...

    Authors: Jeong Sup Song, Chun Mi Kang, Moon Bin Yoo, Seung Joon Kim, Hyung Kyu Yoon, Young Kyoon Kim, Kwan Hyung Kim, Hwa Sik Moon and Sung Hak Park
    Citation: Respiratory Research 2007 8:28
  11. We tested the hypothesis that maternal interleukin-1β (IL-1β) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs.

    Authors: Reshma Bhattacharjee, Tianbo Li, Shyny Koshy, LaMonta L Beard, Kapil Sharma, Ethan P Carter, Chrystelle Garat and Hans G Folkesson
    Citation: Respiratory Research 2007 8:27
  12. Skeletal muscle depletion is an important complication of chronic obstructive pulmonary disease (COPD) but little prospective data exists about the rate at which it occurs and the factors that promote its deve...

    Authors: Nicholas S Hopkinson, Rachel C Tennant, Mark J Dayer, Elisabeth B Swallow, Trevor T Hansel, John Moxham and Michael I Polkey
    Citation: Respiratory Research 2007 8:25
  13. Exposure to cigarette smoke is considered a major risk factor for the development of lung diseases, since its causative role has been assessed in the induction and maintenance of an inflamed state in the airwa...

    Authors: Giampiero La Rocca, Rita Anzalone, Francesca Magno, Felicia Farina, Francesco Cappello and Giovanni Zummo
    Citation: Respiratory Research 2007 8:23
  14. Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF). This study was designed to determine whether airway ...

    Authors: Hiroshi Kanazawa, Kazuhisa Asai and Saeko Nomura
    Citation: Respiratory Research 2007 8:22
  15. Acute exposure to chlorine (Cl2) gas causes epithelial injury and airway dysfunction. γδ T cells are present in the mucosal surface of the airways and may contribute to the injury/repair response of the epitheliu...

    Authors: Hossein Koohsari, Meiyo Tamaoka, Holly R Campbell and James G Martin
    Citation: Respiratory Research 2007 8:21
  16. There is growing epidemiological evidence that short-term and long-term exposure to high levels of air pollution may increase cardiovascular morbidity and mortality. In addition, epidemiological studies have s...

    Authors: Tamara Schikowski, Dorothea Sugiri, Ulrich Ranft, Ulrike Gehring, Joachim Heinrich, H-Erich Wichmann and Ursula Krämer
    Citation: Respiratory Research 2007 8:20
  17. Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood. Toll-like receptor 9 (TLR9) is a receptor for unmethylated CpG dinucleo...

    Authors: Mattias Fransson, Mikael Benson, Jonas S Erjefält, Lennart Jansson, Rolf Uddman, Sven Björnsson, Lars-Olaf Cardell and Mikael Adner
    Citation: Respiratory Research 2007 8:17
  18. Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high ...

    Authors: Lena Uller, Jesper Mosolff Mathiesen, Lisa Alenmyr, Magnus Korsgren, Trond Ulven, Thomas Högberg, Gunnar Andersson, Carl GA Persson and Evi Kostenis
    Citation: Respiratory Research 2007 8:16
  19. Chronic hypoxia induces pulmonary arterial hypertension (PAH). Smooth muscle cell (SMC) proliferation and hypertrophy are important contributors to the remodeling that occurs in chronic hypoxic pulmonary vascu...

    Authors: Renate Paddenberg, Philipp Stieger, Anna-Laura von Lilien, Petra Faulhammer, Anna Goldenberg, Harald H Tillmanns, Wolfgang Kummer and Ruediger C Braun-Dullaeus
    Citation: Respiratory Research 2007 8:15
  20. The aims of this study were to verify the feasibility of respiratory function tests and to assess their validity in the diagnosis of respiratory disorders in young children.

    Authors: Pavilio Piccioni, Alberto Borraccino, Maria Pia Forneris, Enrica Migliore, Carlo Carena, Elisabetta Bignamini, Stefania Fassio, Giorgio Cordola, Walter Arossa and Massimiliano Bugiani
    Citation: Respiratory Research 2007 8:14
  21. In patients with acute respiratory distress syndrome (ARDS), it is well known that only part of the lungs is aerated and surfactant function is impaired, but the extent of lung damage and changes in surfactant...

    Authors: Paola E Cogo, Gianna Maria Toffolo, Carlo Ori, Andrea Vianello, Marco Chierici, Antonina Gucciardi, Claudio Cobelli, Aldo Baritussio and Virgilio P Carnielli
    Citation: Respiratory Research 2007 8:13
  22. Medical and public health importance of pneumococcal infections justifies the implementation of measures capable of reducing their incidence and severity, and explains why the recently marketed heptavalent pne...

    Authors: Susanna Esposito, Alessandro Lizioli, Annalisa Lastrico, Enrica Begliatti, Alessandro Rognoni, Claudia Tagliabue, Laura Cesati, Vittorio Carreri and Nicola Principi
    Citation: Respiratory Research 2007 8:12
  23. Limited data are available concerning patients admitted to the intensive care unit (ICU) for severe haemoptysis. We reviewed a large series of patients managed in a uniform way to describe the clinical spectru...

    Authors: Muriel Fartoukh, Antoine Khalil, Laurence Louis, Marie-France Carette, Bernard Bazelly, Jacques Cadranel, Charles Mayaud and Antoine Parrot
    Citation: Respiratory Research 2007 8:11
  24. Cigarette smoke disrupts the protective barrier established by the airway epithelium through direct damage to the epithelial cells, leading to cell death. Since the morphology of the airway epithelium of smoke...

    Authors: Brian D Gelbman, Adriana Heguy, Timothy P O'Connor, Joseph Zabner and Ronald G Crystal
    Citation: Respiratory Research 2007 8:10
  25. Surfactant protein D (SP-D) plays important roles in innate host defense against influenza A virus (IAV) infection. Common human polymorphisms of SP-D have been found in many human populations and associated w...

    Authors: Kevan L Hartshorn, Mitchell R White, Tesfaldet Tecle, Ida Tornoe, Grith L Sorensen, Erika C Crouch and Uffe Holmskov
    Citation: Respiratory Research 2007 8:9
  26. Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH...

    Authors: William Raoul, Orianne Wagner-Ballon, Guitanouch Saber, Anne Hulin, Elisabeth Marcos, Stéphane Giraudier, William Vainchenker, Serge Adnot, Saadia Eddahibi and Bernard Maitre
    Citation: Respiratory Research 2007 8:8
  27. Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of ...

    Authors: Mark D Eisner, Paul D Blanc, Steve Sidney, Edward H Yelin, Phenius V Lathon, Patricia P Katz, Irina Tolstykh, Lynn Ackerson and Carlos Iribarren
    Citation: Respiratory Research 2007 8:7
  28. Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are members of the Pneumovirinae subfamily of Paramyxoviridae and can cause severe respiratory disease, especially in infants and young children....

    Authors: Barbara Huck, Dieter Neumann-Haefelin, Annette Schmitt-Graeff, Markus Weckmann, Jörg Mattes, Stephan Ehl and Valeria Falcone
    Citation: Respiratory Research 2007 8:6
  29. Existing data on the effect of treatment of latent tuberculosis infection (LTBI) on T-cell responses to Mycobacterium tuberculosis (MTB)-specific antigens are contradictory. Differences in technical aspects of th...

    Authors: Delia Goletti, M Pasquale Parracino, Ornella Butera, Federica Bizzoni, Rita Casetti, Duilio Dainotto, Gianfranco Anzidei, Carla Nisii, Giuseppe Ippolito, Fabrizio Poccia and Enrico Girardi
    Citation: Respiratory Research 2007 8:5
  30. The rapid desensitization of the human prostacyclin (IP) in response to agonist binding has been shown in cell culture. Phosphorylation of the IP receptor by protein kinase C (PKC) has been suggested to be inv...

    Authors: Ralph T Schermuly, Soni S Pullamsetti, Susanne C Breitenbach, Norbert Weissmann, Hossein A Ghofrani, Friedrich Grimminger, Sigrid M Nilius, Karsten Schrör, Jutta Meger-Kirchrath, Werner Seeger and Frank Rose
    Citation: Respiratory Research 2007 8:4
  31. Intranasal inoculation of Streptococcus pneumoniae D39 serotype 2 causes fatal pneumonia in mice. The cytotoxic and inflammatory properties of pneumolysin (PLY) have been implicated in the pathogenesis of pneumoc...

    Authors: María del Mar García-Suárez, Noelia Flórez, Aurora Astudillo, Fernando Vázquez, Roberto Villaverde, Kevin Fabrizio, Liise-Anne Pirofski and Francisco J Méndez
    Citation: Respiratory Research 2007 8:3
  32. Understanding the environmental and genetic risk factors of accelerated lung function decline in the general population is a first step in a prevention strategy against the worldwide increasing respiratory pat...

    Authors: Medea Imboden, Sara H Downs, Oliver Senn, Gabor Matyas, Otto Brändli, Erich W Russi, Christian Schindler, Ursula Ackermann-Liebrich, Wolfgang Berger and Nicole M Probst-Hensch
    Citation: Respiratory Research 2007 8:2
  33. Epithelial to mesenchymal transition (EMT) in alveolar epithelial cells (AECs) has been widely observed in patients suffering interstitial pulmonary fibrosis. In vitro studies have also demonstrated that AECs ...

    Authors: Zhuang Wu, Leilei Yang, Lin Cai, Min Zhang, Xuan Cheng, Xiao Yang and Jun Xu
    Citation: Respiratory Research 2007 8:1
  34. Several studies have demonstrated that long-acting β2-agonists such as salmeterol are beneficial in chronic obstructive pulmonary disease (COPD). A meta-analysis was therefore conducted to review studies in COPD ...

    Authors: Robert A Stockley, Philip J Whitehead and Michael K Williams
    Citation: Respiratory Research 2006 7:147
  35. Overactivation of nuclear factor κB (NF-κB) orchestrates airway eosinophilia, but does not dampen airway hyperresponsiveness in asthma. NF-κB repression by arsenic trioxide (As2O3) contributes to apoptosis of eos...

    Authors: Lin-Fu Zhou, Yi Zhu, Xue-Fan Cui, Wei-Ping Xie, Ai-Hua Hu and Kai-Sheng Yin
    Citation: Respiratory Research 2006 7:146
  36. Adult-derived bone marrow stem cells are capable of reconstituting the haematopoietic system. However there is ongoing debate in the literature as to whether bone marrow derived cells have the ability to popul...

    Authors: Heather MacPherson, Pamela A Keir, Carol J Edwards, Sheila Webb and Julia R Dorin
    Citation: Respiratory Research 2006 7:145
  37. Survival remains an issue in pulmonary hypertension, a chronic disorder that often affects aged human adults. In young adult mice and rats, chronic 50% hypoxia (11% FIO2 or 0.5 atm) induces pulmonary hypertens...

    Authors: Edouard H Debonneuil, Janine Quillard and Etienne-Emile Baulieu
    Citation: Respiratory Research 2006 7:144
  38. Several studies have reported an association between asthma and gastro-oesophageal reflux, but it is unclear which condition develops first. The role of obesity in mediating this association is also unclear. W...

    Authors: Robert J Hancox, Richie Poulton, D Robin Taylor, Justina M Greene, Christene R McLachlan, Jan O Cowan, Erin M Flannery, G Peter Herbison, Malcolm R Sears and Nicholas J Talley
    Citation: Respiratory Research 2006 7:142
  39. The long-acting β2-agonist (LABA) formoterol has an onset of effect comparable to that of salbutamol. Consequently, the combination of formoterol and budesonide in one inhaler, approved for maintenance use, can p...

    Authors: René E Jonkers, Theo A Bantje and René Aalbers
    Citation: Respiratory Research 2006 7:141
  40. Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsib...

    Authors: Jiska B Snoeck-Stroband, Dirkje S Postma, Thérèse S Lapperre, Margot ME Gosman, Henk A Thiadens, Henk F Kauffman, Jacob K Sont, Désirée F Jansen and Peter J Sterk
    Citation: Respiratory Research 2006 7:140
  41. Functional deterioration in cystic fibrosis (CF) may be reflected by increasing bronchial obstruction and, as recently shown, by ventilation inhomogeneities. This study investigated which physiological factors...

    Authors: Richard Kraemer, David N Baldwin, Roland A Ammann, Urs Frey and Sabina Gallati
    Citation: Respiratory Research 2006 7:138
  42. Leukotrienes are increased locally in idiopathic pulmonary fibrosis. Furthermore, a role for these arachidonic acid metabolites has been thoroughly characterized in the animal bleomycin model of lung fibrosis ...

    Authors: Marco Failla, Tiziana Genovese, Emanuela Mazzon, Elisa Gili, Carmelo Muià, Mariangela Sortino, Nunzio Crimi, Achille P Caputi, Salvatore Cuzzocrea and Carlo Vancheri
    Citation: Respiratory Research 2006 7:137
  43. Inflammation is considered to be of primary pathogenic importance in COPD but the evidence on which current understanding is based does not distinguish between cause and effect, and no single mechanism can acc...

    Authors: David G Parr, Andrew J White, Darren L Bayley, Peter J Guest and Robert A Stockley
    Citation: Respiratory Research 2006 7:136
  44. The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently been identified, called Th17 cells, producing IL-17A...

    Authors: Dominique MA Bullens, Els Truyen, Liesbeth Coteur, Ellen Dilissen, Peter W Hellings, Lieven J Dupont and Jan L Ceuppens
    Citation: Respiratory Research 2006 7:135

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