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  1. Inhalation of crystalline silica induces a pulmonary fibrotic degeneration called silicosis caused by the inability of alveolar macrophages to dissolve the crystalline structure of phagocytosed quartz particle...

    Authors: Sonia Scarfì, Mirko Magnone, Chiara Ferraris, Marina Pozzolini, Federica Benvenuto, Umberto Benatti and Marco Giovine
    Citation: Respiratory Research 2009 10:25
  2. The abnormal regulation of neutrophil apoptosis may contribute to the ineffective resolution of inflammation in chronic lung diseases. Multiple signalling pathways are implicated in regulating granulocyte apop...

    Authors: Vanessa Brown, J Stuart Elborn, Judy Bradley and Madeleine Ennis
    Citation: Respiratory Research 2009 10:24
  3. Multiple evidences indicate that inflammation is an event occurring prior to infection in patients with cystic fibrosis. The self-perpetuating inflammatory cycle may play a pathogenic part in this disease. The...

    Authors: Mathilde Rottner, Jean-Marie Freyssinet and M Carmen Martínez
    Citation: Respiratory Research 2009 10:23
  4. Airborne particles entering the respiratory tract may interact with the apical plasma membrane (APM) of epithelial cells and enter them. Differences in the entering mechanisms of fine (between 0.1 μm and 2.5 μ...

    Authors: Christina Brandenberger, Barbara Rothen-Rutishauser, Fabian Blank, Peter Gehr and Christian Mühlfeld
    Citation: Respiratory Research 2009 10:22
  5. Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term ...

    Authors: Alireza Sadeghnejad, Jill A Ohar, Siqun L Zheng, David A Sterling, Gregory A Hawkins, Deborah A Meyers and Eugene R Bleecker
    Citation: Respiratory Research 2009 10:21
  6. Chronic obstructive pulmonary disease (COPD) is a respiratory inflammatory condition with autoimmune features including IgG autoantibodies. In this study we analyze the complexity of the autoantibody response ...

    Authors: Petra Leidinger, Andreas Keller, Sabrina Heisel, Nicole Ludwig, Stefanie Rheinheimer, Veronika Klein, Claudia Andres, Jürg Hamacher, Hanno Huwer, Bernhard Stephan, Ingo Stehle, Hans-Peter Lenhof and Eckart Meese
    Citation: Respiratory Research 2009 10:20
  7. Bronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury (VILI) in very preterm infants. The greatest risk of VILI may be in the immediate period after birth, when the lungs a...

    Authors: Megan J Wallace, Megan E Probyn, Valerie A Zahra, Kelly Crossley, Timothy J Cole, Peter G Davis, Colin J Morley and Stuart B Hooper
    Citation: Respiratory Research 2009 10:19
  8. Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory re...

    Authors: Changsuk Moon, Jeong Ran Han, Hyun-Jung Park, Jong Sik Hah and Jihee Lee Kang
    Citation: Respiratory Research 2009 10:18
  9. Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p...

    Authors: Shiro Mizuno, Herman J Bogaard, Norbert F Voelkel, Yukihiro Umeda, Maiko Kadowaki, Shingo Ameshima, Isamu Miyamori and Takeshi Ishizaki
    Citation: Respiratory Research 2009 10:17
  10. The present document is the result of a consensus reached by a panel of experts from European and non-European countries on Occupational Rhinitis (OR), a disease of emerging relevance which has received little...

    Authors: Gianna Moscato, Olivier Vandenplas, Roy Gerth Van Wijk, Jean-Luc Malo, Luca Perfetti, Santiago Quirce, Jolanta Walusiak, Roberto Castano, Gianni Pala, Denyse Gautrin, Hans De Groot, Ilenia Folletti, Mona Rita Yacoub and Andrea Siracusa
    Citation: Respiratory Research 2009 10:16
  11. To evaluate the sensitivity, specificity and predictive values of fractional exhaled nitric oxide (FENO) for the diagnosis of asthma in general practice.

    Authors: Antonius Schneider, Lisa Tilemann, Tjard Schermer, Lena Gindner, Gunter Laux, Joachim Szecsenyi and Franz Joachim Meyer
    Citation: Respiratory Research 2009 10:15
  12. Recent evidence has underscored the role of hypoxia and angiogenesis in the pathogenesis of idiopathic fibrotic lung disease. Inhibitor of growth family member 4 (ING4) has recently attracted much attention as...

    Authors: Argyris Tzouvelekis, Vassilis Aidinis, Vagelis Harokopos, Andreas Karameris, George Zacharis, Dimitrios Mikroulis, Fotios Konstantinou, Paschalis Steiropoulos, Ioannis Sotiriou, Marios Froudarakis, Ioannis Pneumatikos, Rodoula Tringidou and Demosthenes Bouros
    Citation: Respiratory Research 2009 10:14
  13. Decreased infiltration of Foxp3+ T regulatory cell (Treg) is considered to be critical for the Th1/Th2 dysregulation of nasal polyps, while the cellular mechanism underlying Foxp3+ Treg insufficiency is curren...

    Authors: Geng Xu, Jiahong Xia, Xiaoyang Hua, Han Zhou, Chuanzhao Yu, Zheng Liu, Kemin Cai, Jianbo Shi and Huabin Li
    Citation: Respiratory Research 2009 10:13
  14. Oral corticosteroids and inhaled bronchodilators with or without antibiotics represent standard treatment of COPD exacerbations of moderate severity. Frequent courses of oral steroids may be a safety issue. We...

    Authors: Björn Ställberg, Olof Selroos, Claus Vogelmeier, Eva Andersson, Tommy Ekström and Kjell Larsson
    Citation: Respiratory Research 2009 10:11
  15. Pneumocystis spp. are opportunistic pathogens that cause pneumonia in immunocompromised humans and animals. Pneumocystis colonization has also been detected in immunocompetent hosts and may exacerbate other pulm...

    Authors: Michael J Linke, Alan D Ashbaugh, Jeffery A Demland and Peter D Walzer
    Citation: Respiratory Research 2009 10:10
  16. Alveolar epithelial cells are known as progenitor cells for the restoration from the damage in the lung. Calcitonin gene-related peptide (CGRP) has been reported to play an important role in the proliferation ...

    Authors: Yukiko Kawanami, Yasuo Morimoto, Heungnam Kim, Takehiro Nakamura, Kazuhiko Machida, Takashi Kido, Etsuko Asonuma, Kazuhiro Yatera, Chiharu Yoshii and Masamitsu Kido
    Citation: Respiratory Research 2009 10:8
  17. Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations...

    Authors: Lars Lüthje, Tobias Raupach, Hellmuth Michels, Bernhard Unsöld, Gerd Hasenfuss, Harald Kögler and Stefan Andreas
    Citation: Respiratory Research 2009 10:7
  18. Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for inter...

    Authors: Laurent Savale, Ly Tu, Dominique Rideau, Mohamed Izziki, Bernard Maitre, Serge Adnot and Saadia Eddahibi
    Citation: Respiratory Research 2009 10:6
  19. Asthma can be difficult to diagnose, but bronchial provocation with methacholine, exercise or mannitol is helpful when used to identify bronchial hyperresponsiveness (BHR), a key feature of the disease. The ut...

    Authors: Sandra D Anderson, Brett Charlton, John M Weiler, Sara Nichols, Sheldon L Spector and David S Pearlman
    Citation: Respiratory Research 2009 10:4
  20. Asthma is a chronic airway inflammatory disease characterized by an imbalance in both Th1 and Th2 cytokines. Exhaled nitric oxide (NO) is elevated in asthma, and is a potentially useful non-invasive marker of ...

    Authors: Jingjing Jiang, Nikita Malavia, Vinod Suresh and Steven C George
    Citation: Respiratory Research 2009 10:3
  21. Peripheral blood monocytes (PBMo) originate from the bone marrow, circulate in the blood and emigrate into various organs where they differentiate into tissue resident cellular phenotypes of the mononuclear ph...

    Authors: Zbigniew Zasłona, Jochen Wilhelm, Lidija Cakarova, Leigh M Marsh, Werner Seeger, Jürgen Lohmeyer and Werner von Wulffen
    Citation: Respiratory Research 2009 10:2
  22. Anxiety and depression are common and treatable risk factors for re-hospitalisation and death in patients with COPD. The degree of lung function impairment does not sufficiently explain anxiety and depression....

    Authors: Georg-Christian Funk, Kathrin Kirchheiner, Otto Chris Burghuber and Sylvia Hartl
    Citation: Respiratory Research 2009 10:1
  23. IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal t...

    Authors: Barry J Moynihan, Barbara Tolloczko, Souad El Bassam, Pascale Ferraro, Marie-Claire Michoud, James G Martin and Sophie Laberge
    Citation: Respiratory Research 2008 9:84
  24. Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The T...

    Authors: Andre Zandvoort, Dirkje S Postma, Marnix R Jonker, Jacobien A Noordhoek, Johannes TWM Vos and Wim Timens
    Citation: Respiratory Research 2008 9:83
  25. CD8+ T cells may participate in cigarette smoke (CS) induced-lung inflammation in mice. CXCL10/IP-10 (IFNγ-inducible protein 10) and CXCL9/Mig (monokine induced by IFN-γ) are up-regulated in CS-induced lung in...

    Authors: Li Nie, Ruolan Xiang, Weixun Zhou, Bao Lu, Deyun Cheng and Jinming Gao
    Citation: Respiratory Research 2008 9:82
  26. Oxidative stress plays a potential role in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Glutathione S-transferases (GSTs) detoxify toxic compounds in tobacco smoke via glut...

    Authors: Terttu Harju, Witold Mazur, Heta Merikallio, Ylermi Soini and Vuokko L Kinnula
    Citation: Respiratory Research 2008 9:80
  27. Extracellular adenosine 5'-triphosphate (ATP) is an endogenous signaling molecule involved in multiple biological phenomena, including inflammation. The effects of extracellular ATP in the lung have not been f...

    Authors: Hiroki Matsuyama, Fumimasa Amaya, Soshi Hashimoto, Hiroshi Ueno, Satoru Beppu, Mitsuhiko Mizuta, Nobuaki Shime, Akitoshi Ishizaka and Satoru Hashimoto
    Citation: Respiratory Research 2008 9:79
  28. The aim of this study, conducted in Europe, was to develop a validated risk factor based model to predict RSV-related hospitalisation in premature infants born 33–35 weeks' gestational age (GA).

    Authors: Eric AF Simões, Xavier Carbonell-Estrany, John R Fullarton, Johannes G Liese, Jose Figueras-Aloy, Gunther Doering and Juana Guzman
    Citation: Respiratory Research 2008 9:78
  29. Surfactant protein A (SP-A) enhances phagocytosis of bacteria, including Klebsiella pneumoniae, by alveolar macrophages. Ozone, a major air pollutant, can cause oxidation of surfactant and may influence lung immu...

    Authors: Anatoly N Mikerov, Rizwanul Haque, Xiaozhuang Gan, Xiaoxuan Guo, David S Phelps and Joanna Floros
    Citation: Respiratory Research 2008 9:77
  30. Many cystic fibrosis (CF) patients display airway hyperresponsiveness and have symptoms of asthma such as cough, wheezing and reversible airway obstruction. Chronic airway bacterial colonization, associated wi...

    Authors: Vasanthi Govindaraju, Marie-Claire Michoud, Pasquale Ferraro, Janine Arkinson, Katherine Safka, Hector Valderrama-Carvajal and James G Martin
    Citation: Respiratory Research 2008 9:76
  31. Taffic-related air pollution has been related to adverse respiratory outcomes; however, there is still uncertainty concerning the type of vehicle emission causing most deleterious effects.

    Authors: Maria-Consuelo Escamilla-Nuñez, Albino Barraza-Villarreal, Leticia Hernandez-Cadena, Hortensia Moreno-Macias, Matiana Ramirez-Aguilar, Juan-Jose Sienra-Monge, Marlene Cortez-Lugo, Jose-Luis Texcalac, Blanca del Rio-Navarro and Isabelle Romieu
    Citation: Respiratory Research 2008 9:74
  32. Many patients with chronic obstructive pulmonary disease (COPD) are treated with twice daily (BID) inhaled corticosteroids (ICS). This study evaluated whether daily PM mometasone furoate administered via a dry...

    Authors: Peter MA Calverley, Stephen Rennard, Harold S Nelson, Jill P Karpel, Eduardo H Abbate, Paul Stryszak and Heribert Staudinger
    Citation: Respiratory Research 2008 9:73
  33. Despite its reported pro-inflammatory activity, cyclooxygenase (COX)-2 has been proposed to play a protective role in asthma. Accordingly, COX-2 might be down-regulated in the airway cells of asthmatics. This,...

    Authors: Rosa Torres, Aida Herrerias, Mariona Serra-Pagès, Jordi Roca-Ferrer, Laura Pujols, Alberto Marco, César Picado and Fernando de Mora
    Citation: Respiratory Research 2008 9:72
  34. Sidestream smoke is closely associated with airway inflammation and hyperreactivity. The present study was designed to investigate if the Raf-1 inhibitor GW5074 and the anti-inflammatory drug dexamethasone sup...

    Authors: Ying Lei, Yong-Xiao Cao, Cang-Bao Xu and Yaping Zhang
    Citation: Respiratory Research 2008 9:71
  35. In airway epithelial cells, calcium mobilization can be elicited by selective autocrine and/or paracrine activation of apical or basolateral membrane heterotrimeric G protein-coupled receptors linked to phosph...

    Authors: Fabrice Antigny, Caroline Norez, Anne Cantereau, Frédéric Becq and Clarisse Vandebrouck
    Citation: Respiratory Research 2008 9:70
  36. Bile-duct ligated (BDL) rats recruit pulmonary intravascular macrophages (PIMs) and are highly susceptible to endotoxin-induced mortality. The mechanisms of this enhanced susceptibility and mortality in BDL ra...

    Authors: Sukhjit S Gill, Sarabjeet S Suri, Kyathanahalli S Janardhan, Sarah Caldwell, Tanya Duke and Baljit Singh
    Citation: Respiratory Research 2008 9:69
  37. There is no optimal screening tool for the assessment of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc). A decreasing transfer factor of the lung for CO (TLCO) is associated wi...

    Authors: Maria J Overbeek, Herman Groepenhoff, Alexandre E Voskuyl, Egbert F Smit, Jochem WL Peeters, Anton Vonk-Noordegraaf, Marieke D Spreeuwenberg, Ben C Dijkmans and Anco Boonstra
    Citation: Respiratory Research 2008 9:68
  38. There is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and...

    Authors: Tricia M McKeever, Sarah A Lewis, Henriette A Smit, Peter Burney, Patricia A Cassano and John Britton
    Citation: Respiratory Research 2008 9:67
  39. We have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial cells (HBECs), and that IL-6/STAT3 signal...

    Authors: Xiangde Liu, Shinsaku Togo, Mona Al-Mugotir, Huijung Kim, QiuHong Fang, Tetsu Kobayashi, XingQi Wang, Lijun Mao, Peter Bitterman and Stephen Rennard
    Citation: Respiratory Research 2008 9:66
  40. Surfactant protein D (SP-D) plays an important role in innate defense against influenza A viruses (IAVs) and other pathogens.

    Authors: Kevan L Hartshorn, Richard Webby, Mitchell R White, Tesfaldet Tecle, Clark Pan, Susan Boucher, Rodney J Moreland, Erika C Crouch and Ronald K Scheule
    Citation: Respiratory Research 2008 9:65
  41. In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airw...

    Authors: Margot ME Gosman, Dirkje S Postma, Judith M Vonk, Bea Rutgers, Monique Lodewijk, Mieke Smith, Marjan A Luinge, Nick HT ten Hacken and Wim Timens
    Citation: Respiratory Research 2008 9:64
  42. To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snori...

    Authors: Karl A Franklin, Christer Janson, Thórarinn Gíslason, Amund Gulsvik, Maria Gunnbjörnsdottir, Birger N Laerum, Eva Lindberg, Eva Norrman, Lennarth Nyström, Ernst Omenaas, Kjell Torén and Cecilie Svanes
    Citation: Respiratory Research 2008 9:63
  43. Guidelines on COPD diagnosis and management encourage primary care physicians to detect the disease at an early stage and to treat patients according to their condition and needs. Problems in guideline impleme...

    Authors: Rupert CM Jones, Maria Dickson-Spillmann, Martin JC Mather, Dawn Marks and Bryanie S Shackell
    Citation: Respiratory Research 2008 9:62
  44. Accidental chlorine (Cl2) gas inhalation is a common cause of acute airway injury. However, little is known about the kinetics of airway injury and repair after Cl2 exposure. We investigated the time course of ai...

    Authors: Stephanie A Tuck, David Ramos-Barbón, Holly Campbell, Toby McGovern, Harry Karmouty-Quintana and James G Martin
    Citation: Respiratory Research 2008 9:61
  45. Secretory leukoproteinase inhibitor (SLPI) is an important inhibitor of neutrophil elastase (NE), a proteinase implicated in the pathogenesis of lung diseases such as COPD. SLPI also has antimicrobial and anti...

    Authors: Anita L Sullivan, Timothy Dafforn, Pieter S Hiemstra and Robert A Stockley
    Citation: Respiratory Research 2008 9:60
  46. Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets. Mice with genetic deletions of scavenge...

    Authors: Timothy H Sulahian, Amy Imrich, Glen DeLoid, Aaron R Winkler and Lester Kobzik
    Citation: Respiratory Research 2008 9:59

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    Journal Impact Factor: 4.7
    5-year Journal Impact Factor: 5.3
    Source Normalized Impact per Paper (SNIP): 1.192
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