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  1. Short PLUNC1 (SPLUNC1) is the founding member of a family of proteins (PLUNCS) expressed in the upper respiratory tract and oral cavity, which may function in host defence. It is one of the most highly express...

    Authors: Lynne Bingle, Frances A Barnes, Simon S Cross, Doris Rassl, William A Wallace, Michael A Campos and Colin D Bingle
    Citation: Respiratory Research 2007 8:79
  2. Contents of the epithelial lining fluid (ELF) of the bronchi are of central interest in lung diseases, acute lung injury and pharmacology. The most commonly used technique broncheoalveolar lavage is invasive a...

    Authors: Stig S Tyvold, Erik Solligård, Oddveig Lyng, Sigurd L Steinshamn, Sigurd Gunnes and Petter Aadahl
    Citation: Respiratory Research 2007 8:78
  3. Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell (PASMC) in vivo and in vitro, and prostacyclin analogues are thought to inhibit the growth of PASMC. Previous studies suggest that p27kip...

    Authors: Maiko Kadowaki, Shiro Mizuno, Yoshiki Demura, Shingo Ameshima, Isamu Miyamori and Takeshi Ishizaki
    Citation: Respiratory Research 2007 8:77
  4. Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood. Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides wh...

    Authors: Ziemowit Zietkowski, Roman Skiepko, Maria M Tomasiak and Anna Bodzenta-Lukaszyk
    Citation: Respiratory Research 2007 8:76
  5. Sepsis remains the leading cause of death in critically ill patients. One of the primary organs affected by sepsis is the lung, presenting as the Acute Respiratory Distress Syndrome (ARDS). Organ damage in sep...

    Authors: Luminita Eid, Zohar Bromberg, Mahmoud Abd EL-Latif, Evelyn Zeira, Ariella Oppenheim and Yoram G Weiss
    Citation: Respiratory Research 2007 8:74
  6. Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant ...

    Authors: John M Nicholls, Anthony J Bourne, Honglin Chen, Yi Guan and JS Malik Peiris
    Citation: Respiratory Research 2007 8:73
  7. Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9). This leads in particular...

    Authors: Pascal Knuefermann, Georg Baumgarten, Alexander Koch, Markus Schwederski, Markus Velten, Heidi Ehrentraut, Jan Mersmann, Rainer Meyer, Andreas Hoeft, Kai Zacharowski and Christian Grohé
    Citation: Respiratory Research 2007 8:72
  8. IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, rem...

    Authors: Hugues Chanteux, Amélie C Guisset, Charles Pilette and Yves Sibille
    Citation: Respiratory Research 2007 8:71
  9. Surfactant protein D (SP-D) deficient mice develop emphysema-like pathology associated with focal accumulations of foamy alveolar macrophages, an excess of surfactant phospholipids in the alveolar space and bo...

    Authors: Lars Knudsen, Matthias Ochs, Rosemarie MacKay, Paul Townsend, Roona Deb, Christian Mühlfeld, Joachim Richter, Fabian Gilbert, Samuel Hawgood, Kenneth Reid and Howard Clark
    Citation: Respiratory Research 2007 8:70
  10. Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and is thought to participate in innate pulmonary host defense. We hypothesized th...

    Authors: Hanna Müller, Caroline End, Marcus Renner, Burkhard M Helmke, Nikolaus Gassler, Christel Weiss, Dominik Hartl, Matthias Griese, Mathias Hafner, Annemarie Poustka, Jan Mollenhauer and Johannes Poeschl
    Citation: Respiratory Research 2007 8:69
  11. Airway hyper-responsiveness (AHR) is a key feature of asthma and a causal relationship between airway inflammation and AHR has been identified. The aim of the current study was to clarify the effect of proinfl...

    Authors: Natalie Smith, Claudia A Browning, Nathalie Duroudier, Ceri Stewart, Samantha Peel, Caroline Swan, Ian P Hall and Ian Sayers
    Citation: Respiratory Research 2007 8:68
  12. Few studies have compared treatment strategies in patients with asthma poorly controlled on low dose inhaled corticosteroids, and little is known about the effects of different treatments on airway inflammatio...

    Authors: Ian Pavord, Ashley Woodcock, Debbie Parker and Leanne Rice
    Citation: Respiratory Research 2007 8:67
  13. The therapeutic effect of inhaled corticosteroids (ICS) may be affected by the metabolism of the drug in the target organ. We investigated the in vitro metabolism of beclomethasone dipropionate (BDP), budesonide ...

    Authors: Ruediger Nave, Robyn Fisher and Nigel McCracken
    Citation: Respiratory Research 2007 8:65
  14. Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome characterized by varying degrees of airflow limitation and diffusion impairment. There is increasing evidence to suggest that COPD is al...

    Authors: Janet S Lee, Matthew R Rosengart, Venkateswarlu Kondragunta, Yingze Zhang, Jessica McMurray, Robert A Branch, Augustine MK Choi and Frank C Sciurba
    Citation: Respiratory Research 2007 8:64
  15. Inspiratory occlusion evoked cortical potentials (the respiratory related-evoked potentials, RREPs) bear witness of the processing of changes in respiratory mechanics by the brain. Their impairment in children...

    Authors: Brigitte Fauroux, Francis Renault, Pierre Yves Boelle, Christine Donzel-Raynaud, Frédéric Nicot, Annick Clément, Christian Straus and Thomas Similowski
    Citation: Respiratory Research 2007 8:61

    The Correction to this article has been published in Respiratory Research 2008 9:22

  16. Vascular endothelial growth factor (VEGF), a substance that stimulates new blood vessel formation, is an important survival factor for endothelial cells. Although overexpressed VEGF in the lung induces pulmona...

    Authors: Hidefumi Koh, Sadatomo Tasaka, Naoki Hasegawa, Wakako Yamada, Mie Shimizu, Morio Nakamura, Makoto Yonemaru, Eiji Ikeda, Yoshiyuki Adachi, Seitaro Fujishima, Kazuhiro Yamaguchi and Akitoshi Ishizaka
    Citation: Respiratory Research 2007 8:60
  17. In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this v...

    Authors: Craig P Hersh, Dawn L DeMeo, John J Reilly and Edwin K Silverman
    Citation: Respiratory Research 2007 8:59
  18. Circulating Endothelial Precursors (PB-EPCs) are involved in the maintenance of the endothelial compartment being promptly mobilized after injuries of the vascular endothelium, but the effects of a brief normo...

    Authors: Michele M Ciulla, Michela Cortiana, Ilaria Silvestris, Emanuela Matteucci, Elisa Ridolfi, Fabrizio Giofrè, Maddalena Zanardelli, Roberta Paliotti, Agostino Cortelezzi, Alberto Pierini, Fabio Magrini and Maria Alfonsina Desiderio
    Citation: Respiratory Research 2007 8:58
  19. Vaccination against Pseudomonas aeruginosa is a desirable albeit challenging strategy for prevention of airway infection in patients with cystic fibrosis. We assessed the immunogenicity of a nasal vaccine based o...

    Authors: Ulrich Baumann, Kerstin Göcke, Britta Gewecke, Joachim Freihorst and Bernd Ulrich von Specht
    Citation: Respiratory Research 2007 8:57
  20. Offspring of asthmatic mothers have increased risk of developing asthma, based on human epidemiologic data and experimental animal models. The objective of this study was to determine whether maternal allergy ...

    Authors: Robert H Lim, Mohamed S Arredouani, Alexey Fedulov, Lester Kobzik and Cedric Hubeau
    Citation: Respiratory Research 2007 8:56
  21. Alterations to pulmonary surfactant composition have been encountered in the Acute Respiratory Distress Syndrome (ARDS). However, only few data are available regarding the time-course and duration of surfactan...

    Authors: Reinhold Schmidt, Philipp Markart, Clemens Ruppert, Malgorzata Wygrecka, Tim Kuchenbuch, Dieter Walmrath, Werner Seeger and Andreas Guenther
    Citation: Respiratory Research 2007 8:55
  22. Patients with bronchitis type of chronic obstructive pulmonary disease (COPD) have raised vascular endothelial growth factor (VEGF) levels in induced sputum. This has been associated with the pathogenesis of C...

    Authors: Nikoletta Rovina, Andreas Papapetropoulos, Androniki Kollintza, Makrina Michailidou, Davina CM Simoes, Charis Roussos and Christina Gratziou
    Citation: Respiratory Research 2007 8:53
  23. This study compared the effect of inhaled fluticasone propionate (FP) with the combination of salmeterol/fluticasone propionate (SFC) on lung function parameters in patients with mild asthma.

    Authors: Catherine M Houghton, Naomi Lawson, Zoe L Borrill, Claire L Wixon, Sally Yoxall, Stephen J Langley, Ashley Woodcock and Dave Singh
    Citation: Respiratory Research 2007 8:52
  24. The pleiotrophic cytokine interleukin (IL)-13 features prominently in allergic and inflammatory diseases. In allergic asthma, IL-13 is well established as an inducer of airway inflammation and tissue remodelin...

    Authors: Brian W Booth, Tracy Sandifer, Erika L Martin and Linda D Martin
    Citation: Respiratory Research 2007 8:51
  25. Bone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells ...

    Authors: Christian M Kähler, Jutta Wechselberger, Wolfgang Hilbe, Andreas Gschwendtner, Daniela Colleselli, Harald Niederegger, Eva-Maria Boneberg, Gilbert Spizzo, Albrecht Wendel, Eberhard Gunsilius, Josef R Patsch and Jürg Hamacher
    Citation: Respiratory Research 2007 8:50
  26. Tobacco smoke is the principal risk factor for chronic obstructive pulmonary disease (COPD), though the mechanisms of its toxicity are still unclear. The ABC transporters multidrug resistance-associated protei...

    Authors: Margaretha van der Deen, Wim Timens, Hetty Timmer-Bosscha, Barry W van der Strate, Rik J Scheper, Dirkje S Postma, Elisabeth G de Vries and Huib A Kerstjens
    Citation: Respiratory Research 2007 8:49
  27. The major contribution to oxidant related lung damage in COPD is from the oxidant/antioxidant imbalance and possibly impaired antioxidant defence. Glutathione (GSH) is one of the most important antioxidants in...

    Authors: Terttu H Harju, Mirva J Peltoniemi, Paula H Rytilä, Ylermi Soini, Kaisa M Salmenkivi, Philip G Board, Lloyd W Ruddock and Vuokko L Kinnula
    Citation: Respiratory Research 2007 8:48
  28. Although the contribution of alveolar type II epithelial cell (AEC II) activities in various aspects of respiratory immune regulation has become increasingly appreciated, our understanding of the contribution ...

    Authors: Marcus Gereke, Lothar Gröbe, Silvia Prettin, Michael Kasper, Stefanie Deppenmeier, Achim D Gruber, Richard I Enelow, Jan Buer and Dunja Bruder
    Citation: Respiratory Research 2007 8:47
  29. Improving patients' health-related quality of life (HRQoL) is recognized as a fundamental part of asthma management. The aims of this study were to evaluate the long-term efficacy (including symptom-free days ...

    Authors: David B Price, Angela E Williams and Sally Yoxall
    Citation: Respiratory Research 2007 8:46
  30. Non-small cell lung cancer (NSCLC) causes most of cancer related deaths in humans and is characterized by poor prognosis regarding efficiency of chemotherapeutical treatment and long-term survival of the patie...

    Authors: Dagmar S Lang, Daniel Droemann, Holger Schultz, Detlev Branscheid, Christian Martin, Anne R Ressmeyer, Peter Zabel, Ekkehard Vollmer and Torsten Goldmann
    Citation: Respiratory Research 2007 8:43
  31. Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). W...

    Authors: Kondwani C Jambo, Neil French, Ed Zijlstra and Stephen B Gordon
    Citation: Respiratory Research 2007 8:42
  32. Azithromycin reduces the severity of illness in patients with inflammatory lung disease such as cystic fibrosis and diffuse panbronchiolitis. Bronchopulmonary dysplasia (BPD) is a pulmonary disorder which caus...

    Authors: Hubert O Ballard, Michael I Anstead and Lori A Shook
    Citation: Respiratory Research 2007 8:41
  33. Repeated bronchoalveolar lavage (BAL) has been used in animals to induce surfactant depletion and to study therapeutical interventions of subsequent respiratory insufficiency. Intratracheal administration of s...

    Authors: Mario Rüdiger, Sebastian Wendt, Lars Köthe, Wolfram Burkhardt, Roland R Wauer and Matthias Ochs
    Citation: Respiratory Research 2007 8:40
  34. Mucin hypersecretion and mucus plugging in the airways are characteristic features of chronic respiratory diseases like cystic fibrosis (CF) and contribute to morbidity and mortality. In CF, Pseudomonas aeruginos...

    Authors: Daniel Tetaert, Maud Pierre, Dominique Demeyer, Marie-Odile Husson, Laurent Béghin, Claude Galabert, Frédéric Gottrand, Christopher Beermann, Benoit Guery and Jean-Luc Desseyn
    Citation: Respiratory Research 2007 8:39
  35. Developing strategies for controlling the severity of pandemic influenza is a global public health priority. In the event of a pandemic there may be a place for inexpensive, readily available, effective adjunc...

    Authors: Paul Rennie, Philip Bowtell, David Hull, Duane Charbonneau, Robert Lambkin-Williams and John Oxford
    Citation: Respiratory Research 2007 8:38
  36. The most common pathologic form of pulmonary fibrosis arises from excessive deposition of extracellular matrix proteins such as collagen. The 47 kDa heat shock protein 47 (HSP47) is a collagen-specific molecul...

    Authors: Satoshi Hagiwara, Hideo Iwasaka, Shigekiyo Matsumoto and Takayuki Noguchi
    Citation: Respiratory Research 2007 8:37
  37. Heparin has been shown to modify fundamental biologic processes ranging from blood coagulation and cell proliferation to fibrogenesis and asthma. The goal of this study was to identify specific or broad biolog...

    Authors: Amir A Gabr, Mathew Reed, Donna R Newman, Jan Pohl, Jody Khosla and Philip L Sannes
    Citation: Respiratory Research 2007 8:36
  38. Antidepressants are heavily prescribed drugs and have been shown to affect inflammatory signals. We examined whether these have anti-inflammatory properties in animal models of septic shock and allergic asthma...

    Authors: Caroline Roumestan, Alain Michel, Florence Bichon, Karine Portet, Maëlle Detoc, Corinne Henriquet, Dany Jaffuel and Marc Mathieu
    Citation: Respiratory Research 2007 8:35
  39. Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes ...

    Authors: Jennifer L Ingram, Aurita Antao-Menezes, Elizabeth A Turpin, Duncan G Wallace, James B Mangum, Linda J Pluta, Russell S Thomas and James C Bonner
    Citation: Respiratory Research 2007 8:34
  40. In the diagnosis of early-stage lung cancer photosensitizer-enhanced fluorescence bronchoscopy with inhaled 5-aminolevolinic acid (5-ALA) increases sensitivity when compared to white-light bronchoscopy. This i...

    Authors: Hubert Hautmann, Josef P Pichler, Herbert Stepp, Reinhold Baumgartner, Fernando Gamarra and Rudolf M Huber
    Citation: Respiratory Research 2007 8:33
  41. Recently, it has been shown that increasing body mass index (BMI) in asthma is associated with reduced exhaled NO. Our objective in this study was to determine if the BMI-related changes in exhaled NO differ a...

    Authors: Sushma Komakula, Sumita Khatri, Joel Mermis, Samira Savill, Shireen Haque, Mauricio Rojas, LouAnn Brown, Gerald W Teague and Fernando Holguin
    Citation: Respiratory Research 2007 8:32
  42. Proteinase-activated receptors (PARs; PAR1–4) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases inclu...

    Authors: Seijitsu Ando, Hitomi Otani, Yasuhiro Yagi, Kenzo Kawai, Hiromasa Araki, Shirou Fukuhara and Chiyoko Inagaki
    Citation: Respiratory Research 2007 8:31
  43. For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic revie...

    Authors: Milo A Puhan, Daniela Vollenweider, Tsogyal Latshang, Johann Steurer and Claudia Steurer-Stey
    Citation: Respiratory Research 2007 8:30

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