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  1. The link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose rangin...

    Authors: Mark A Birrell, Cliff H Battram, Paul Woodman, Kerryn McCluskie and Maria G Belvisi

    Citation: Respiratory Research 2003 4:2

    Content type: Research

    Published on:

  2. Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expres...

    Authors: Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine and Joseph B Shrager

    Citation: Respiratory Research 2003 4:3

    Content type: Research

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  3. Chronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α is considered to play a role. In the presen...

    Authors: Mehmet Küçükaycan, Michiel Van Krugten, Herman-Jan Pennings, Tom WJ Huizinga, Wim A Buurman, Mieke A Dentener and Emiel FM Wouters

    Citation: Respiratory Research 2002 3:28

    Content type: Research

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  4. The predictive role of many cytokines and adhesion molecules has not been studied systematically in acute respiratory distress syndrome (ARDS).

    Authors: Panagiotis Agouridakis, Despina Kyriakou, Michael G Alexandrakis, Athanasios Prekates, Kostas Perisinakis, Nikolaos Karkavitsas and Demosthenes Bouros

    Citation: Respiratory Research 2002 3:27

    Content type: Research

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  5. Chronic lung disease (CLD) of prematurity is a major problem of neonatal care. Bacterial infection and inflammatory response have been thought to play an important role in the development of CLD and steroids h...

    Authors: Ying-Hua Li, Zhong-Qun Yan, Annelie Brauner and Kjell Tullus

    Citation: Respiratory Research 2002 3:16

    Content type: Research

    Published on:

  6. Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared. Additionally, the role of...

    Authors: Susanne Kruse, Sandra Braun and Klaus A Deichmann

    Citation: Respiratory Research 2002 3:17

    Content type: Research

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  7. Neutrophils constitute the first line of defense against invading microorganisms. Whereas these cells readily undergo apoptosis under homeostatic conditions, their survival is prolonged during inflammatory rea...

    Authors: Vasanthi R Sunil, Agnieszka J Connor, Peihong Zhou, Marion K Gordon, Jeffrey D Laskin and Debra L Laskin

    Citation: Respiratory Research 2002 3:14

    Content type: Research

    Published on:

  8. To demonstrate the involvement of tobacco smoking in the pathophysiology of lung disease, the responses of pulmonary epithelial cells to cigarette smoke condensate (CSC) — the particulate fraction of tobacco s...

    Authors: Gary R Hellermann, Szilvia B Nagy, Xiaoyuan Kong, Richard F Lockey and Shyam S Mohapatra

    Citation: Respiratory Research 2002 3:15

    Content type: Research

    Published on:

  9. Respiratory syncytial virus (RSV) is the most common viral pathogen that causes lower respiratory tract infections in infants. Studies have implicated severe RSV infections early in life as a risk factor for s...

    Authors: Lone Graff Stensballe

    Citation: Respiratory Research 2002 3(Suppl 1):8

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  10. The incidence, prevalence, and mortality of asthma have increased in children over the past three to four decades, although there has been some decline in the most recent decade. These trends are particularly ...

    Authors: Rosalind L Smyth

    Citation: Respiratory Research 2002 3(Suppl 1):7

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  11. Asthma is a leading cause of morbidity and mortality among children worldwide, as is respiratory syncytial virus (RSV). This report reviews controlled retrospective and prospective studies conducted to investi...

    Authors: Nele Sigurs

    Citation: Respiratory Research 2002 3(Suppl 1):5

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  12. There is substantial epidemiological evidence supporting the concept that respiratory syncytial virus (RSV) lower respiratory tract infection in infancy may be linked to the development of reactive airway dise...

    Authors: Giovanni Piedimonte

    Citation: Respiratory Research 2002 3(Suppl 1):4

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  13. Viral bronchiolitis is the most common cause of hospitalization in infants under 6 months of age, and 70% of all cases of bronchiolitis are caused by respiratory syncytial virus (RSV). Early RSV infection is a...

    Authors: Peter JM Openshaw

    Citation: Respiratory Research 2002 3(Suppl 1):3

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  14. Respiratory syncytial virus (RSV) is the primary cause of hospitalization for acute respiratory tract illness in general and specifically for bronchiolitis in young children. The link between RSV bronchiolitis...

    Authors: Jan LL Kimpen

    Citation: Respiratory Research 2002 3(Suppl 1):2

    Content type: Supplement

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  15. Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three pre...

    Authors: Alissa K Greenberg, Herman Yee and William N Rom

    Citation: Respiratory Research 2002 3:13

    Content type: Review

    Published on:

  16. Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely infla...

    Authors: Gehan Devendra and Roger G Spragg

    Citation: Respiratory Research 2002 3:11

    Content type: Review

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  17. Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (I...

    Authors: Roberto Cruz-Gervis, Arlene A Stecenko, Ryszard Dworski, Kirk B Lane, James E Loyd, Richard Pierson, Gayle King and Kenneth L Brigham

    Citation: Respiratory Research 2002 3:9

    Content type: Research

    Published on:

  18. The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at...

    Authors: Michael C Iannuzzi, Mary Maliarik and Benjamin Rybicki

    Citation: Respiratory Research 2002 3:7

    Content type: Review

    Published on:

  19. Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been...

    Authors: Panagiotis Pantelidis, Srihari Veeraraghavan and Roland M du Bois

    Citation: Respiratory Research 2001 3:14

    Content type: Review

    Published on:

  20. The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease (COPD). COPD is caused by cigarette smoking, evidenced by deterioration in lung function. Lung ...

    Authors: David Hele

    Citation: Respiratory Research 2001 3:12

    Content type: Meeting report

    Published on:

  21. The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmac...

    Authors: Ian P Hall

    Citation: Respiratory Research 2001 3:10

    Content type: Review

    Published on:

  22. Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing...

    Authors: W Craig Hooper and Christine De Staercke

    Citation: Respiratory Research 2001 3:8

    Content type: Commentary

    Published on:

  23. Pulmonary surfactant is a unique mixture of lipids and surfactant-specific proteins that covers the entire alveolar surface of the lungs. Surfactant is not restricted to the alveolar compartment; it also reach...

    Authors: Jens M Hohlfeld

    Citation: Respiratory Research 2001 3:4

    Content type: Review

    Published on:

  24. The acute respiratory distress syndrome (ARDS) is a frequent, life-threatening disease in which a marked increase in alveolar surface tension has been repeatedly observed. It is caused by factors including a l...

    Authors: Andreas Günther, Clemens Ruppert, Reinhold Schmidt, Philipp Markart, Friedrich Grimminger, Dieter Walmrath and Werner Seeger

    Citation: Respiratory Research 2001 2:353

    Content type: Review

    Published on:

  25. Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growt...

    Authors: Tushar J Desai and Wellington V Cardoso

    Citation: Respiratory Research 2001 3:2

    Content type: Commentary

    Published on:

  26. Previous studies have revealed that tumour necrosis factor (TNF)-α is upregulated in fibrosing alveolitis (FA) in humans. The aim of this study was to compare the TNF-α secretory profile of alveolar macrophage...

    Authors: Panos Pantelidis, Deirdre S McGrath, Anne Marie Southcott, Carol M Black and Roland M du Bois

    Citation: Respiratory Research 2001 2:365

    Content type: Research

    Published on:

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