Articles

Simple circuits to maintain isocapnia regardless of ventilation

Authors: JA Fisher, A Vesely, H Sasano, R Somogyi, G Volgyesi, L Fedorko and S Iscoe

Abdominal muscle spindle discharge does not affect abdominal motoneuronal discharge in decerebrate cats

Authors: S Iscoe

Abstract not submitted for publication

Authors:

Synaptic interactions of retrogradely labeled genioglossus motoneurons with substance P-like immunoreactive terminals in the cat: a double labeling immunoelectron microscopic study

Authors: PJ Gatti and KA Richardson

The effect of volitional breathing on the breathlessness-ventilation relationship during progressive exercise in healthy subjects

Authors: JW Reed and MMF Subhan

Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia

Authors: T O'Hare, M McGuire, KD O'Halloran and A Bradford

Neonatal maternal separation alters development of the hypercapnic ventilatory response in awake adult rats

Authors: SE Genest, R Gulemetova, S Laforest, G Drolet and R Kinkead

Prenatal hypoxia impairs the early postnatal development of the carotid chemoafferent pathway

Authors: JC Roux, J Peyronnet, J Mamet, D Perrin, H Lagercrantz, Y Dalmaz and JM Pequignot

Selective inhibition of the sodium proton exchanger subtype 3 (NHE3) as a tool to study central chemosensitivity

Authors: M Wiemann, H Kiwull-Schöne, P Kiwull and D Bingmann

Respiratory-related neuronal activity in the nucleus ambiguus-retroambigualis complex and their responses to peripheral and central stimulation in the rat

Authors: RJ Balnave, ZG Huang, SH Subramanian and AB Turman

Distribution and classification of respiratory neurones in the nucleus tractus solitarius of the rat medulla and their responses to central and periphereal stimuli

Authors: RJ Balnave, CM Chow, ZG Huang and SH Subramanian

Phase-coupling of the respiratory network by somatosensory receptors during locomotion

Authors: JT Potts and JFR Paton

Normobaric CO₂ and hyperbaric O₂ stimulate the same neurons in the solitary complex

Authors: JB Dean

CO₂chemotransduction in central neurons: role of intracellular pH (pH_i) and extracellular pH (pH_o)

Authors: RW Putnam

On synchronizing pH-sensitive subthreshold oscillations of membrane potential in locus coeruleus (LC) neurones

Authors: M Andrzejewski, D Ballantyne, K Mückenhoff and P Scheid

Regulation of tyrosine-hydroxylase (TH) gene expression by hypoxia and von Hippel-Lindau tumor suppressor complex

Authors: AL Bauer, MF Czyzyk-Krzeska, J Nash, WR Paulding, PO Schnell and JB Striet

CNS changes in chronic hypoxia

Authors: NM Aguilar N, CB Kim, FL Powell and SG Reid

Network interactions in inspiratory (I) and expiratory (E) neuron populations as indicated by high-frequency oscillations

Authors: MI Cohen, WR See, W-X Huang, Q Yu, AR Granata and K Nakazawa

Time domains of the sympatho-respiratory response to hypoxia: plasticity in phrenic and sympathetic nerve activities

Authors: TE Dick, SK Coles, Y-H Hsieh, S Morrison and N Prabhakar

Contribution of cholinergic systems to state-dependent modulation of respiratory networks

Authors: MC Bellingham, GD Funk, MF Ireland, GB Miles, DM Robinson and SR Selvaratnam

Oscillations in inspiratory synaptic inputs: role in controlling the repetitive firing behaviour of inspiratory motoneurons

Authors: GD Funk, JL Feldman, DM Robinson and MA Parkis

Substance P and NK₁receptor activation within the ventral medullary respiratory network prolongs expiratory time

Authors: P Boscan, JE Smith and JFR Paton

Site(s) and mechanism of changes in arterial chemo-sensitivity after carotid (CBD) and/or aortic (AOD) denervation

Authors: HV Forster, A Serra, T Lowry and R Franciosi

Carotid body dopaminergic mechanisms during acclimatization to hypoxia

Authors: GE Bisgard, JA Herman, PL Janssen and KD O'Halloran

Integral-differential calculus computations by short-term potentiation and depression in NTS-pontine pathways

Authors: C-S Poon

Serotonin-dependent respiratory plasticity

Authors: GS Mitchell, TL Baker, DD Fuller and RW Bavis

Central mechanisms controlling upper airway patency

Authors: M Dutschmann and JFR Paton

Distribution of calcium binding proteins, sodium channels and persistent sodium current in the rat ventral respiratory group

Authors: DR McCrimmon, GF Alheid, K Ptak, PA Gray, G Zummo, S Escobar and JL Feldman

Prenatal nicotine exposure up-regulates catecholaminergic traits in peripheral arterial chemoreceptors of newborn rat pups

Authors: EB Gauda, R Cooper, PR Akins and G Wu

Phylogeny of central CO₂/pH chemoreception in vertebrates

Authors: WK Milsom

Early development of respiratory rhythm generation in mice and chicks

Authors: J Champagnat, G Fortin, S Jungbluth, V Abadie, F Chatonnet, E Dominquez-del-Toro and L Guimarães

Small airway inflammation in asthma

Asthma was originally described as an inflammatory disease that predominantly involves the central airways. Pathological and physiological evidence reported during the past few years suggests that the inflamma...

Authors: Meri K Tulic, Pota Christodoulopoulos and Qutayba Hamid

The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea

Obstructive sleep apnoea is a common and serious breathing problem that is caused by effects of sleep on pharyngeal muscle tone in individuals with narrow upper airways. There has been increasing focus on deli...

Authors: Richard L Horner

'CFTR-opathies': disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations

Cystic fibrosis is a genetic disease that is associated with abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into genotype/phenotype relat...

Authors: Peadar G Noone and Michael R Knowles

Glycosylation and the cystic fibrosis transmembrane conductance regulator

The cystic fibrosis transmembrane conductance regulator (CFTR) has been known for the past 11 years to be a membrane glycoprotein with chloride channel activity. Only recently has the glycosylation of CFTR bee...

Authors: Thomas F Scanlin and Mary Catherine Glick

Airway obstruction in asthma: does the response to a deep inspiration matter?

Airway hyperresponsiveness in asthma may not be a problem of too much airway smooth muscle strength. Rather, it may be a problem of too little of the factors that oppose muscle shortening. The weight of availa...

Authors: Jeffrey J Fredberg

Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease

Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cel...

Authors: Elizabeth S Klings and Harrison W Farber

Tumor necrosis factor-α and muscle wasting: a cellular perspective

Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct eff...

Authors: Michael B Reid and Yi-Ping Li

Neurotrophins in bronchial asthma

Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been ...

Authors: Harald Renz

Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to evidence?

Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been reported between the intake of fruit, fish, ant...

Authors: Henriëtte A Smit

Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco

The program at this year's American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lun...

Authors: Ian Woolhouse

New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18-23, San Francisco

The 97^th American Thoracic Society meeting proved to be an excellent meeting, providing a wealth of new information on inflammatory diseases of the airways. Once again there appeared to be an increased emphasis o...

Authors: David J Hele

Viruses, dendritic cells and the lung

The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tac...

Authors: R Stokes Peebles Jr and Barney S Graham

Early immune development, atopy and asthma: insights from ATS 2001, May 18-23, San Francisco

There is rising evidence that the initiation of atopy and asthma may occur in early life or even during fetal life. At the American Thoracic Society meeting 2001 in San Francisco, multiple reports addressed ep...

Authors: Christian H Schroeter and Patricia W Finn

Primary ciliary dyskinesia: a report from ATS 2001, May 18–23, San Francisco

Primary ciliary dyskinesia (PCD) is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in oto-sino-pulmonary disease, and infertility. The di...

Authors: Peadar G Noone

Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitutions using an amplification refractory mutation systempolymerase chain reactionassay: studies in patients with asthma

The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105→Val105 substitution are associated with the asthma pheno...

Authors: Anja Hemmingsen, Anthony A Fryer, Michael Hepple, Richard C Strange and Monica A Spiteri

Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension

Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology that is associated with the inheritance an...

Authors: Mark De Caestecker and Barbara Meyrick

Pharmacology of airway afferent nerve activity

Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve activity can be subclassified into compounds that...

Authors: Bradley J Undem and Michael J Carr

Gene expression in epithelial cells in response to pneumovirus infection

Respiratory syncytial virus (RSV) and pneumonia virus of mice (PVM) are viruses of the family Paramyxoviridae, subfamily pneumovirus, which cause clinically important respiratory infections in humans and roden...

Authors: Joseph B Domachowske, Cynthia A Bonville and Helene F Rosenberg

Skeletal muscle dysfunction in chronic obstructive pulmonary disease

It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatig...

Authors: M Jeffery Mador and Erkan Bozkanat