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  1. Content type: Review

    Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allo...

    Authors: Jean-Michel Sallenave

    Citation: Respiratory Research 2000 1:5

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  2. Content type: Commentary

    Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent oxidative stress. Although NO• is known to have ant...

    Authors: Albert van der Vliet, Jason P Eiserich and Carroll E Cross

    Citation: Respiratory Research 2000 1:1

    Published on:

  3. Content type: Review

    Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathol...

    Authors: Kate Blease, Nicholas W Lukacs, Cory M Hogaboam and Steven L Kunkel

    Citation: Respiratory Research 2000 1:13

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  4. Content type: Review

    The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quant...

    Authors: Yassine Amrani, Hang Chen and Reynold A Panettieri Jr

    Citation: Respiratory Research 2000 1:12

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  5. Content type: Commentary

    PM10 (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies...

    Authors: Kenneth Donaldson, M Ian Gilmour and William MacNee

    Citation: Respiratory Research 2000 1:5

    Published on:

  6. Content type: Review

    The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opp...

    Authors: Edward Gabrielson

    Citation: Respiratory Research 2000 1:10

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  7. Content type: Commentary

    The limitations of currently available treatment for severe respiratory infection are demonstrated by the relatively fixed mortality associated with these infections despite advances in nutrition, vaccines, an...

    Authors: K Kolls Jay and Steve Nelson

    Citation: Respiratory Research 2000 1:4

    Published on:

  8. Content type: Review

    Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of...

    Authors: Alison M Condliffe, Karen A Cadwallader, Trevor R Walker, Robert C Rintoul, Andrew S Cowburn and Edwin R Chilvers

    Citation: Respiratory Research 2000 1:8

    Published on:

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