Skip to content



Page 5 of 51

  1. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition in which an important extra-pulmonary manifestation is cardiovascular disease. We hypothesized that COPD patients would have inc...

    Authors: Marie Fisk, Joseph Cheriyan, Divya Mohan, Carmel M. McEniery, Julia Forman, John R. Cockcroft, James H. F. Rudd, Ruth Tal-Singer, Nicholas S. Hopkinson, Michael I. Polkey and Ian B. Wilkinson

    Citation: Respiratory Research 2018 19:100

    Published on:

  2. Content type: Research

    Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function declin...

    Authors: Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang and Ji Ye Jung

    Citation: Respiratory Research 2018 19:99

    Published on:

  3. Content type: Research

    Asthma is a chronic respiratory condition, with airway hyperresponsiveness (AHR) and inflammation as hallmarks. The hypothesis that the substantially increased expression of arginase 1 in activated macrophages...

    Authors: Roy H. E. Cloots, Matthew E. Poynter, Els Terwindt, Wouter H. Lamers and S. Eleonore Köhler

    Citation: Respiratory Research 2018 19:98

    Published on:

  4. Content type: Research

    The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP...

    Authors: Nina S. Godtfredsen, Ditte V. Jørgensen, Kristoffer Marsaa, Charlotte S. Ulrik, Ove Andersen, Jesper Eugen-Olsen and Line J. H. Rasmussen

    Citation: Respiratory Research 2018 19:97

    Published on:

  5. Content type: Research

    Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently,...

    Authors: Stephanie Everaerts, Elise J. Lammertyn, Dries S. Martens, Laurens J. De Sadeleer, Karen Maes, Aernoud A. van Batenburg, Roel Goldschmeding, Coline H. M. van Moorsel, Lieven J. Dupont, Wim A. Wuyts, Robin Vos, Ghislaine Gayan-Ramirez, Naftali Kaminski, James C. Hogg, Wim Janssens, Geert M. Verleden…

    Citation: Respiratory Research 2018 19:95

    Published on:

  6. Content type: Research

    Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking o...

    Authors: Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He and Ping Yang

    Citation: Respiratory Research 2018 19:94

    Published on:

  7. Content type: Research

    Intrauterine infection/inflammation plays an important role in the development of lung injury and bronchopulmonary dysplasia (BPD) in preterm infants, While a multifactorial genesis is likely, mechanisms invol...

    Authors: Jiarong Pan, Canyang Zhan, Tianming Yuan, Weiyan Wang, Ying Shen, Yi Sun, Tai Wu, Weizhong Gu, Lihua Chen and Huimin Yu

    Citation: Respiratory Research 2018 19:93

    Published on:

  8. Content type: Research

    Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of huma...

    Authors: Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson and Jeffrey C. Horowitz

    Citation: Respiratory Research 2018 19:91

    Published on:

  9. Content type: Research

    Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affe...

    Authors: P. Heukels, J. A. C. van Hulst, M. van Nimwegen, C. E. Boorsma, B. N. Melgert, L. M. van den Toorn, K. A. T. Boomars, M. S. Wijsenbeek, H. Hoogsteden, J. H. von der Thüsen, R. W. Hendriks, M. Kool and B. van den Blink

    Citation: Respiratory Research 2018 19:90

    Published on:

  10. Content type: Research

    Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especi...

    Authors: Maria G. Belvisi, Katie Baker, Nicole Malloy, Kristof Raemdonck, Bilel Dekkak, Michael Pieper, Anthony T. Nials and Mark A. Birrell

    Citation: Respiratory Research 2018 19:89

    Published on:

  11. Content type: Research

    Preclinical data suggest that oncogene (EGFR and KRAS) events regulate tumor procoagulant activity. However, few studies have prospectively investigated the clinical relevance between the presence of EGFR or K...

    Authors: Feifei Dou, Huiqiao Li, Min Zhu, Lirong Liang, Yuan Zhang, Jiawen Yi and Yuhui Zhang

    Citation: Respiratory Research 2018 19:88

    Published on:

  12. Content type: Research

    Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder associated with high pulmonary artery pressure. Genetic testing enables early diagnosis and offers an opportunity for family screening....

    Authors: Hang Yang, Qixian Zeng, Yanyun Ma, Bingyang Liu, Qianlong Chen, Wenke Li, Changming Xiong and Zhou Zhou

    Citation: Respiratory Research 2018 19:87

    Published on:

  13. Content type: Research

    Cardiovascular disease are common co-morbidities in bronchiectasis and contribute substantially to disease burden and mortality. Brachial-ankle pulse wave velocity (baPWV), a measure of arterial stiffness, has...

    Authors: Yong-hua Gao, Juan-juan Cui, Ling-yun Wang, Ke-qin Yin, Li Wang, Guo-jun Zhang and Shao-xia Liu

    Citation: Respiratory Research 2018 19:86

    Published on:

  14. Content type: Research

    COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the ...

    Authors: Mark M. Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J. Halayko, Ian Adcock and Kian Fan Chung

    Citation: Respiratory Research 2018 19:85

    Published on:

  15. Content type: Research

    The REVOLENS study compared lung volume reduction coil treatment to usual care in patients with severe emphysema at 1 year, resulting in improved quality-adjusted life-year (QALY) and higher costs. Durability ...

    Authors: Julie Bulsei, Sylvie Leroy, Jeanne-Marie Perotin, Hervé Mal, Charles-Hugo Marquette, Hervé Dutau, Arnaud Bourdin, Jean-Michel Vergnon, Christophe Pison, Romain Kessler, Vincent Jounieaux, Mathieu Salaün, Armelle Marceau, Sylvain Dukic, Coralie Barbe, Margaux Bonnaire…

    Citation: Respiratory Research 2018 19:84

    Published on:

  16. Content type: Research

    Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm characterized by the pulmonary infiltration of smooth muscle-like cells (LAM cells) and cystic destruction. Patients usually present with airway obstructi...

    Authors: Ellen Caroline Toledo do Nascimento, Bruno Guedes Baldi, Alessandro Wasum Mariani, Raquel Annoni, Ronaldo Adib Kairalla, Suzana Pinheiro Pimenta, Luiz Fernando Ferraz da Silva, Carlos Roberto Ribeiro Carvalho and Marisa Dolhnikoff

    Citation: Respiratory Research 2018 19:83

    Published on:

  17. Content type: Research

    Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease a...

    Authors: Jannie M. B. Sand, Yoshinori Tanino, Morten A. Karsdal, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Xintao Wang, Diana J. Leeming and Mitsuru Munakata

    Citation: Respiratory Research 2018 19:82

    Published on:

  18. Content type: Research

    Pneumonia is responsible for approximately 230,000 deaths in Europe, annually. Comprehensive and comparable reports on pneumonia mortality trends across the European Union (EU) are lacking.

    Authors: Dominic C. Marshall, Ross J. Goodson, Yiwang Xu, Matthieu Komorowski, Joseph Shalhoub, Mahiben Maruthappu and Justin D. Salciccioli

    Citation: Respiratory Research 2018 19:81

    Published on:

  19. Content type: Research

    Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implic...

    Authors: Judith J. M. Ceelen, Annemie M. W. J. Schols, Nathalie G. M. Thielen, Astrid Haegens, Douglas A. Gray, Marco C. J. M. Kelders, Chiel C. de Theije and Ramon C. J. Langen

    Citation: Respiratory Research 2018 19:80

    Published on:

  20. Content type: Correction

    In the original publication [1] is an error in table 1. The correct version can be found in this Erratum:

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael O. Silva

    Citation: Respiratory Research 2018 19:77

    Published on:

    The original article was published in Respiratory Research 2018 19:13

  21. Content type: Research

    In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify...

    Authors: Alison G. Lee, Blake Le Grand, Hsiao-Hsien Leon Hsu, Yueh-Hsiu Mathilda Chiu, Kasey J. Brennan, Sonali Bose, Maria José Rosa, Kelly J. Brunst, Itai Kloog, Ander Wilson, Joel Schwartz, Wayne Morgan, Brent A. Coull, Robert O. Wright, Andrea A. Baccarelli and Rosalind J. Wright

    Citation: Respiratory Research 2018 19:76

    Published on:

  22. Content type: Research

    Whole lung lavage is the current standard therapy for pulmonary alveolar proteinosis (PAP) that is characterized by the alveolar accumulation of surfactant. Rituximab showed promising results in auto-immune PA...

    Authors: Berenice Soyez, Raphael Borie, Cedric Menard, Jacques Cadranel, Leonidas Chavez, Vincent Cottin, Emmanuel Gomez, Sylvain Marchand-Adam, Sylvie Leroy, Jean-Marc Naccache, Hilario Nunes, Martine Reynaud-Gaubert, Laurent Savale, Abdellatif Tazi, Lidwine Wemeau-Stervinou, Marie-Pierre Debray…

    Citation: Respiratory Research 2018 19:74

    Published on:

  23. Content type: Research

    Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with variou...

    Authors: Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke and Michael Kreuter

    Citation: Respiratory Research 2018 19:73

    Published on:

  24. Content type: Research

    Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death...

    Authors: L. Torre-Bouscoulet, W. R. Muñoz-Montaño, D. Martínez-Briseño, F. J. Lozano-Ruiz, R. Fernández-Plata, J. A. Beck-Magaña, C. García-Sancho, A. Guzmán-Barragán, E. Vergara, M. Blake-Cerda, L. Gochicoa-Rangel, F. Maldonado, M. Arroyo-Hernández and O. Arrieta

    Citation: Respiratory Research 2018 19:72

    Published on:

  25. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory ...

    Authors: Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe…

    Citation: Respiratory Research 2018 19:71

    Published on:

  26. Content type: Correction

    In the original publication [1] is an incorrect sentence in the abstract under Conclusions.

    Authors: Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi and Stefano Centanni

    Citation: Respiratory Research 2018 19:70

    Published on:

    The original article was published in Respiratory Research 2018 19:18

  27. Content type: Research

    Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possibl...

    Authors: Olga Rafikova, Anup Srivastava, Ankit A. Desai, Ruslan Rafikov and Stevan P. Tofovic

    Citation: Respiratory Research 2018 19:69

    Published on:

  28. Content type: Research

    Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and...

    Authors: Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord and Lena Gustavsson

    Citation: Respiratory Research 2018 19:68

    Published on:

  29. Content type: Research

    In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we...

    Authors: Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg and Claudia A. Staab-Weijnitz

    Citation: Respiratory Research 2018 19:67

    Published on:

  30. Content type: Letter to the Editor

    Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternativ...

    Authors: Elena Mitsi, Raphael Kamng’ona, Jamie Rylance, Carla Solórzano, J. Jesus Reiné, Henry C. Mwandumba, Daniela M. Ferreira and Kondwani C. Jambo

    Citation: Respiratory Research 2018 19:66

    Published on:

  31. Content type: Research

    Corticosteroids increase the expression of β2-adrenoceptors (β2-ARs) and protect them against down-regulation. Conversely, β2-AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it ...

    Authors: Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola and Paola Rogliani

    Citation: Respiratory Research 2018 19:65

    Published on:

  32. Content type: Research

    The imbalance between proteases and anti-proteases is considered to contribute to the development of COPD. Our aim was to evaluate the protease MMP-9, the antiprotease TIMP-1 and the MMP-9/TIMP-1-ratio as biom...

    Authors: Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie F. Behndig, Anders Blomberg and Anne Lindberg

    Citation: Respiratory Research 2018 19:64

    Published on:

  33. Content type: Research

    Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencin...

    Authors: James D. Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson and Alicia Gayle

    Citation: Respiratory Research 2018 19:63

    Published on:

  34. Content type: Research

    Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypo...

    Authors: Alejandro A. Diaz, Carlos H. Martinez, Rola Harmouche, Thomas P. Young, Merry-Lynn McDonald, James C. Ross, Mei Lan Han, Russell Bowler, Barry Make, Elizabeth A. Regan, Edwin K. Silverman, James Crapo, Aladin M. Boriek, Gregory L. Kinney, John E. Hokanson, Raul San Jose Estepar…

    Citation: Respiratory Research 2018 19:62

    Published on:

  35. Content type: Research

    Obstructive sleep apnea (OSA) is highly prevalent in patients with coronary artery disease (CAD) and is associated with recurrent cardiovascular risk. However, whether treatment with continuous positive airway...

    Authors: Xiao Wang, Ying Zhang, Zhimin Dong, Jingyao Fan, Shaoping Nie and Yongxiang Wei

    Citation: Respiratory Research 2018 19:61

    Published on:

  36. Content type: Research

    It is unknown if the plasma lipidome is a useful tool for improving our understanding of the acute respiratory distress syndrome (ARDS). Therefore, we measured the plasma lipidome of individuals with ARDS at t...

    Authors: Michael D. Maile, Theodore J. Standiford, Milo C. Engoren, Kathleen A. Stringer, Elizabeth S. Jewell, Thekkelnaycke M. Rajendiran, Tanu Soni and Charles F. Burant

    Citation: Respiratory Research 2018 19:60

    Published on:

  37. Content type: Research

    Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the gene...

    Authors: Ma’en Obeidat, Guohai Zhou, Xuan Li, Nadia N. Hansel, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré and Don D. Sin

    Citation: Respiratory Research 2018 19:59

    Published on:

  38. Content type: Research

    Chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in world. Cigarette smoke is known to cause oxidative stress and deplete glutathione (GSH) levels. Nuclear erythroid-rel...

    Authors: Mahin Dianat, Maryam Radan, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati and Masoumeh Ahmadizadeh

    Citation: Respiratory Research 2018 19:58

    Published on:

  39. Content type: Research

    Gastric contents aspiration in humans has variable consequences depending on the volume of aspirate, ranging from subclinical pneumonitis to respiratory failure with up to 70% mortality. Several experimental a...

    Authors: Pedro Ayala, Jorge Torres, Raúl Vivar, Manuel Meneses, Pablo Olmos, Tamara San Martin and Gisella R. Borzone

    Citation: Respiratory Research 2018 19:57

    Published on:

  40. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to e...

    Authors: Maxine J. Roberts, Rebecca E. Broome, Toby C. Kent, Steven J. Charlton and Elizabeth M. Rosethorne

    Citation: Respiratory Research 2018 19:56

    Published on:

  41. Content type: Research

    A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, th...

    Authors: Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier and Henrik Watz

    Citation: Respiratory Research 2018 19:55

    Published on:

  42. Content type: Review

    In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered i...

    Authors: Alexandra McCarron, Martin Donnelley and David Parsons

    Citation: Respiratory Research 2018 19:54

    Published on:

  43. Content type: Research

    Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway sm...

    Authors: Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala and Kentaro Mizuta

    Citation: Respiratory Research 2018 19:53

    Published on:

  44. Content type: Research

    Patients with chronic obstructive pulmonary disease (COPD) experience symptoms that vary over the day. Symptoms at the start of the day might influence physical activity during the rest of the day. Therefore, ...

    Authors: Amanda R. van Buul, Marise J. Kasteleyn, Niels H. Chavannes and Christian Taube

    Citation: Respiratory Research 2018 19:49

    Published on:

2017 Journal Metrics