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  1. Research

    Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling

    The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis of asthma. House dust mite (HDM), one of the most important allergens, could increase the airway epi...

    Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li and Shao-xi Cai

    Respiratory Research 2017 18:111

    Published on: 30 May 2017

  2. Research

    Evaluation of two strategies for the interpretation of tumour markers in pleural effusions

    Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help to identif...

    Jaume Trapé, Francesc Sant, Josefina Franquesa, Jesús Montesinos, Anna Arnau, Maria Sala, Oscar Bernadich, Esperanza Martín, Damià Perich, Concha Pérez, Joan Lopez, Sandra Ros, Enrique Esteve, Rafael Pérez, Jordi Aligué, Gabriel Gurt…

    Respiratory Research 2017 18:103

    Published on: 25 May 2017

  3. Research

    In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor

    Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The Sonic hedgehog (SHH) pathway is involved in vascular physiology. We sought to establish whether the SHH pathway has a...

    Priscilla Henno, Stanislas Grassin-Delyle, Emeline Belle, Marion Brollo, Emmanuel Naline, Edouard Sage, Philippe Devillier and Dominique Israël-Biet

    Respiratory Research 2017 18:102

    Published on: 23 May 2017

  4. Research

    Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs

    In acute respiratory respiratory distress syndrome (ARDS) a sustained mismatch of alveolar ventilation and perfusion (VA/Q) impairs the pulmonary gas exchange. Measurement of endexpiratory lung volume (EELV) by m...

    Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David and Erik K. Hartmann

    Respiratory Research 2017 18:101

    Published on: 23 May 2017

  5. Research

    Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients

    COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical manifestations of COPD and this classifica...

    Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers and Leo Koenderman

    Respiratory Research 2017 18:100

    Published on: 22 May 2017

  6. Research

    Reduced HDAC2 in skeletal muscle of COPD patients

    Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The...

    Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito and Peter J. Barnes

    Respiratory Research 2017 18:99

    Published on: 19 May 2017

  7. Research

    Genome-wide association study of subclinical interstitial lung disease in MESA

    We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis ...

    Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko…

    Respiratory Research 2017 18:97

    Published on: 18 May 2017

  8. Review

    Lung function imaging methods in Cystic Fibrosis pulmonary disease

    Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a cl...

    Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan and Bruce R. Thompson

    Respiratory Research 2017 18:96

    Published on: 17 May 2017

  9. Research

    High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging

    The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world’s widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the i...

    Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall and David W. Parsons

    Respiratory Research 2017 18:95

    Published on: 16 May 2017

  10. Research

    Immunohistology and remodeling in fatal pediatric and adolescent asthma

    Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and ado...

    Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna and Mika J. Mäkelä

    Respiratory Research 2017 18:94

    Published on: 16 May 2017

  11. Research

    Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

    Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying ...

    Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan and Jeremy A. Hirota

    Respiratory Research 2017 18:92

    Published on: 15 May 2017

  12. Research

    Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages

    Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA me...

    Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang and Changfu Hao

    Respiratory Research 2017 18:91

    Published on: 12 May 2017

  13. Research

    COPD monocytes demonstrate impaired migratory ability

    Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of...

    Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo and Dave Singh

    Respiratory Research 2017 18:90

    Published on: 11 May 2017

  14. Research

    Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury

    In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved th...

    Marta Camprubí–Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch and Antonio Artigas

    Respiratory Research 2017 18:89

    Published on: 10 May 2017

  15. Research

    Selective gene expression analysis of the neuroepithelial body microenvironment in postnatal lungs with special interest for potential stem cell characteristics

    The pulmonary neuroepithelial body (NEB) microenvironment (ME) consists of innervated cell clusters that occur sparsely distributed in the airway epithelium, an organization that has so far hampered reliable s...

    Line Verckist, Robrecht Lembrechts, Sofie Thys, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns and Dirk Adriaensen

    Respiratory Research 2017 18:87

    Published on: 8 May 2017

  16. Research

    Blood and sputum eosinophils in COPD; relationship with bacterial load

    Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bact...

    Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Respiratory Research 2017 18:88

    Published on: 8 May 2017

  17. Research

    Rhinovirus C targets ciliated airway epithelial cells

    The Rhinovirus C (RV-C), first identified in 2006, produce high symptom burdens in children and asthmatics, however, their primary target host cell in the airways remains unknown. Our primary hypotheses were t...

    Theodor F. Griggs, Yury A. Bochkov, Sarmila Basnet, Thomas R. Pasic, Rebecca A. Brockman-Schneider, Ann C. Palmenberg and James E. Gern

    Respiratory Research 2017 18:84

    Published on: 4 May 2017

  18. Research

    Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

    Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associ...

    Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman and Darryl A. Knight

    Respiratory Research 2017 18:82

    Published on: 3 May 2017

  19. Research

    2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

    Chronic obstructive pulmonary disease (COPD) is associated with several extra-pulmonary effects of which skeletal muscle wasting is one of the most common and contributes to reduced quality of life, increased ...

    Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos and Roberto A. Rabinovich

    Respiratory Research 2017 18:81

    Published on: 3 May 2017

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