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  1. Previous studies have found associations between asthma morbidity and air pollution especially in young population, (PLoS One 12:e0180522, 2017; Can J Public Health 103:4-8, 2012; Environ Health Perspect 118:4...

    Authors: Feifei Liu, Fangfang Qu, Huiran Zhang, Lingshan Chao, Rongqin Li, Fengxue Yu, Jitao Guan and Xixin Yan

    Citation: Respiratory Research 2019 20:122

    Content type: Research

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  2. A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease ...

    Authors: Junling Zhao, Miao Li, Zhihua Wang, Jinkun Chen, Jianping Zhao, Yongjian Xu, Xiang Wei, Jianmao Wang and Jungang Xie

    Citation: Respiratory Research 2019 20:120

    Content type: Research

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  3. Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1...

    Authors: Jin Jin, Shinsaku Togo, Kotaro Kadoya, Miniwan Tulafu, Yukiko Namba, Moe Iwai, Junko Watanabe, Kumi Nagahama, Takahiro Okabe, Moulid Hidayat, Yuzo Kodama, Hideya Kitamura, Takashi Ogura, Norikazu Kitamura, Kazuho Ikeo, Shinichi Sasaki…

    Citation: Respiratory Research 2019 20:119

    Content type: Research

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  4. The mechanisms of lung injury in acute respiratory distress syndrome (ARDS) are not well understood.Piezo1 was recently identified as a mechanotransduction protein. The present study found the expression of Pi...

    Authors: Guo-Peng Liang, Jing Xu, Li-li Cao, Yi-Hua Zeng, Bai-Xu Chen, Jing Yang, Zhong-Wei Zhang and Yan Kang

    Citation: Respiratory Research 2019 20:118

    Content type: Research

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  5. Connective tissue disease associated with interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD) alone have same pathological and imaging backgrounds. However, the differences between lung can...

    Authors: Won-Il Choi, Dong Yoon Lee, Hyun-Gi Choi and Choong Won Lee

    Citation: Respiratory Research 2019 20:117

    Content type: Research

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  6. Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung up...

    Authors: Monica P. Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M. D’Armiento and Lynne L. Johnson

    Citation: Respiratory Research 2019 20:116

    Content type: Research

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  7. Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...

    Authors: James E. Gern, Daniel J. Jackson, Robert F. Lemanske Jr, Christine M. Seroogy, Umberto Tachinardi, Mark Craven, Stephen Y. Hwang, Carol M. Hamilton, Wayne Huggins, George T. O’Connor, Diane R. Gold, Rachel Miller, Meyer Kattan, Christine C. Johnson, Dennis Ownby, Edward M. Zoratti…

    Citation: Respiratory Research 2019 20:115

    Content type: Study protocol

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  8. Chronic obstructive pulmonary disease (COPD) frequent exacerbators (FE) suffer increased morbidity and mortality compared to infrequent exacerbators (IE). The association between the oral and sputum microbiota...

    Authors: Alexa A. Pragman, Katherine A. Knutson, Trevor J. Gould, Richard E. Isaacson, Cavan S. Reilly and Chris H. Wendt

    Citation: Respiratory Research 2019 20:114

    Content type: Research

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  9. The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly und...

    Authors: Li Long, Hongmei Yao, Jing Tian, Wei Luo, Xinxin Yu, Fang Yi, Qiaoli Chen, Jiaxing Xie, Nanshan Zhong, Kian Fan Chung and Kefang Lai

    Citation: Respiratory Research 2019 20:112

    Content type: Research

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  10. Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PA...

    Authors: Annette D. Rieg, Nina A. Bünting, Christian Cranen, Said Suleiman, Jan W. Spillner, Heike Schnöring, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Paul W. Manley, Gereon Schälte, Rolf Rossaint, Stefan Uhlig and Christian Martin

    Citation: Respiratory Research 2019 20:111

    Content type: Research

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  11. Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model ...

    Authors: Fajer Al-Shamlan and Ahmed Z. El-Hashim

    Citation: Respiratory Research 2019 20:110

    Content type: Research

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  12. The differential diagnosis of paediatric respiratory conditions is difficult and suboptimal. Existing diagnostic algorithms are associated with significant error rates, resulting in misdiagnoses, inappropriate...

    Authors: Paul Porter, Udantha Abeyratne, Vinayak Swarnkar, Jamie Tan, Ti-wan Ng, Joanna M. Brisbane, Deirdre Speldewinde, Jennifer Choveaux, Roneel Sharan, Keegan Kosasih and Phillip Della

    Citation: Respiratory Research 2019 20:81

    Content type: Research

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  13. Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously ...

    Authors: Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch and Fumito Ichinose

    Citation: Respiratory Research 2019 20:109

    Content type: Research

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  14. Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and ...

    Authors: Xiao-feng Xiong, Min Zhu, Hong-xia Wu, Li-li Fan and De-yun Cheng

    Citation: Respiratory Research 2019 20:108

    Content type: Research

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  15. Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships...

    Authors: Laurie Snyder, Megan L. Neely, Anne S. Hellkamp, Emily O’Brien, Joao de Andrade, Craig S. Conoscenti, Thomas Leonard, Shaun Bender, Mridu Gulati, Daniel A. Culver, Robert J. Kaner, Scott Palmer and Hyun Joo Kim

    Citation: Respiratory Research 2019 20:105

    Content type: Research

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  16. Tumor chemo-resistance is a hallmark of malignant tumors as well as the major cause of poor survival rates in lung cancer. Transmembrane-4 L-six family member-1 (TM4SF1), an antigen that serves as an oncogene, ma...

    Authors: Lin Ye, Chunyun Pu, Jun Tang, Yan Wang, Can Wang, Zhu Qiu, Tingxiu Xiang, Yunmei Zhang and Weiyan Peng

    Citation: Respiratory Research 2019 20:106

    Content type: Research

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  17. To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in ch...

    Authors: Paola Rogliani, Maria Gabriella Matera, Clive Page, Ermanno Puxeddu, Mario Cazzola and Luigino Calzetta

    Citation: Respiratory Research 2019 20:104

    Content type: Research

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  18. Surveys and retrospective studies of patients with idiopathic pulmonary fibrosis (IPF) have shown a significant diagnostic delay. However, the causes and risk factors for this delay are not known.

    Authors: Nils Hoyer, Thomas Skovhus Prior, Elisabeth Bendstrup, Torgny Wilcke and Saher Burhan Shaker

    Citation: Respiratory Research 2019 20:103

    Content type: Research

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  19. Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypot...

    Authors: Petra Um-Bergström, Jenny Hallberg, Melvin Pourbazargan, Eva Berggren-Broström, Giovanni Ferrara, Maria J. Eriksson, Sven Nyrén, Jing Gao, Gunnar Lilja, Anders Lindén, Åsa M. Wheelock, Erik Melén and C. Magnus Sköld

    Citation: Respiratory Research 2019 20:102

    Content type: Research

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  20. The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry,...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, Ronald A. Karwoski, Cosimo Nardi, Riccardo Inchingolo, Anna R. Larici, Gianna Camiciottoli, Federico Lavorini, Stefano Colagrande, Vito Brusasco and Massimo Pistolesi

    Citation: Respiratory Research 2019 20:101

    Content type: Research

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  21. Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calc...

    Authors: Merry-Lynn N. McDonald, Emiel F. M. Wouters, Erica Rutten, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Marcas Bamman, Bartolome Celli, Alvar Agusti, Ruth Tal-Singer, Craig P. Hersh, Mark Dransfield and Edwin K. Silverman

    Citation: Respiratory Research 2019 20:100

    Content type: Research

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  22. Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin serum levels. Interestingly, patients with Chronic Obstr...

    Authors: Cédric Vonarburg, Marius Loetscher, Martin O. Spycher, Alain Kropf, Marlies Illi, Sharon Salmon, Sean Roberts, Karin Steinfuehrer, Ian Campbell, Sandra Koernig, Joseph Bain, Monika Edler, Ulrich Baumann, Sylvia Miescher, Dennis W. Metzger, Alexander Schaub…

    Citation: Respiratory Research 2019 20:99

    Content type: Research

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  23. Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and ...

    Authors: Wilfried Karmaus, Nandini Mukherjee, Vimala Devi Janjanam, Su Chen, Hongmei Zhang, Graham Roberts, Ramesh J. Kurukulaaratchy and Hasan Arshad

    Citation: Respiratory Research 2019 20:98

    Content type: Research

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  24. We recently showed that intravenous sodium nitroprusside treatment (SNP) could relieve the pulmonary vasospasm of pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions in a rabbit massive pulmona...

    Authors: Yuting Wang, Delong Yu, Yijun Yu, Wusong Zou, Xiaohui Zeng, Liqun Hu and Ye Gu

    Citation: Respiratory Research 2019 20:97

    Content type: Research

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  25. Nitric oxide is a mediator of potential importance in numerous physiological and inflammatory processes in the lung. Aminoguanidine (AG) has been shown to have anti-inflammation and radical scavenging properti...

    Authors: Saeideh Saadat, Farimah Beheshti, Vahid Reza Askari, Mahmoud Hosseini, Nema Mohamadian Roshan and Mohammad Hossein Boskabady

    Citation: Respiratory Research 2019 20:96

    Content type: Research

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  26. Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflam...

    Authors: Lei Liu, Xin Zhang, Ying Liu, Li Zhang, Jing Zheng, Ji Wang, Philip M. Hansbro, Lei Wang, Gang Wang and Alan Chen-Yu Hsu

    Citation: Respiratory Research 2019 20:95

    Content type: Research

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  27. Tobacco smoke exposure impairs the lung’s innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has antimicrobial activi...

    Authors: Patrick J. Moore, Juliana Sesma, Neil E. Alexis and Robert Tarran

    Citation: Respiratory Research 2019 20:94

    Content type: Research

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  28. One of the known weaknesses of spirometry is its dependence on patients’ cooperation, which can only partially be alleviated by educational efforts. Therefore, procedures less dependent on cooperation might be...

    Authors: Christina Kellerer, Neele Jankrift, Rudolf A. Jörres, Klaus Klütsch, Stefan Wagenpfeil, Klaus Linde and Antonius Schneider

    Citation: Respiratory Research 2019 20:92

    Content type: Research

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  29. Wheezing among children below the age of six (pre-schoolers) is common and often triggered by environmental factors. Moreover, evidence on which to base recommendations for its management is limited, resulting...

    Authors: Sonia Trabelsi, Lidia Casas, Benoit Nemery, Tim S. Nawrot and Isabelle Thomas

    Citation: Respiratory Research 2019 20:90

    Content type: Research

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  30. The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Init...

    Authors: Florin Mihaltan, Yochai Adir, Adam Antczak, Konstantinos Porpodis, Vesna Radulovic, Nuno Pires, Geeuwke Jan de Vries, Andreas Horner, Samuel De Bontridder, Yunqin Chen, Anat Shavit, Silviu Alecu and Lukasz Adamek

    Citation: Respiratory Research 2019 20:89

    Content type: Research

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  31. While additional oxygen supply is often required for the survival of very premature infants in intensive care, this also brings an increasing risk of progressive lung diseases and poor long-term lung outcomes....

    Authors: Stefanie Endesfelder, Evelyn Strauß, Till Scheuer, Thomas Schmitz and Christoph Bührer

    Citation: Respiratory Research 2019 20:88

    Content type: Research

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  32. Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechani...

    Authors: Eva Schruf, Victoria Schroeder, Christian A. Kuttruff, Sabine Weigle, Martin Krell, Maryke Benz, Tom Bretschneider, Alexander Holweg, Michael Schuler, Manfred Frick, Paul Nicklin, James P. Garnett and Mirko C. Sobotta

    Citation: Respiratory Research 2019 20:87

    Content type: Research

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  33. Platelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between p...

    Authors: Ashraf Fawzy, Julie A. Anderson, Nicholas J. Cowans, Courtney Crim, Robert Wise, Julie C. Yates and Nadia N. Hansel

    Citation: Respiratory Research 2019 20:86

    Content type: Research

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  34. Although bronchodilator inhaler therapy can improve lung function in patients with tuberculous destroyed lung (TDL), its effect on mortality has not been studied. We evaluated the effect of tiotropium inhaler ...

    Authors: Ho Cheol Kim, Tae Hoon Kim, Ye-Jee Kim, Chin Kook Rhee and Yeon-Mok Oh

    Citation: Respiratory Research 2019 20:85

    Content type: Research

    Published on:

  35. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction ca...

    Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang and Qin Wang

    Citation: Respiratory Research 2019 20:84

    Content type: Research

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  36. An inverse relationship between oral corticosteroid (OCS) dose and peripheral blood eosinophil (PBE) count is widely recognized in patients with severe eosinophilic asthma; however, there are limited data avai...

    Authors: Charlene M. Prazma, Elisabeth H. Bel, Robert G. Price, Eric S. Bradford, Frank C. Albers and Steven W. Yancey

    Citation: Respiratory Research 2019 20:83

    Content type: Letter to the Editor

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  37. Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Antibiotics are losing their effectiveness due to the emerging infectious diseases, the scarcity of novel antibiotics...

    Authors: Yali Zheng, Pu Ning, Qiongzhen Luo, Yukun He, Xu Yu, Xiaohui Liu, Yusheng Chen, Xiaorong Wang, Yu Kang and Zhancheng Gao

    Citation: Respiratory Research 2019 20:82

    Content type: Research

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  38. Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap...

    Authors: Hye-Rim Kang, Sung-Hyun Hong, So-Young Ha, Tae-Bum Kim and Eui-Kyung Lee

    Citation: Respiratory Research 2019 20:80

    Content type: Research

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  39. C-X-C chemokine receptor type 4 (CXCR4) may be involved in the development of pulmonary arterial hypertension (PAH). CXCR4 inhibitor AMD3100 was described to have a positive effect on the prevention of pulmona...

    Authors: Tingting Zhang, Nanako Kawaguchi, Kenji Yoshihara, Emiko Hayama, Yoshiyuki Furutani, Kayoko Kawaguchi, Takeshi Tanaka and Toshio Nakanishi

    Citation: Respiratory Research 2019 20:79

    Content type: Research

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  40. In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance. High-resolution computed tomography (HRCT) of the lung c...

    Authors: Ernesto Crisafulli, Elisabetta Teopompi, Silvia Luceri, Francesco Longo, Panagiota Tzani, Paolo Pagano, Antonella Ielpo, Chiara Longo, Marcello Di Paolo, Nicola Sverzellati, Paolo Palange, Alfredo Chetta and Giovanna Pisi

    Citation: Respiratory Research 2019 20:78

    Content type: Research

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  41. Decreased airway lumen size and increased lung volume are major structural changes in chronic obstructive pulmonary disease (COPD). However, even though the outer wall of the airways is connected with lung par...

    Authors: Naoya Tanabe, Susumu Sato, Tsuyoshi Oguma, Hiroshi Shima, Atsuyasu Sato, Shigeo Muro and Toyohiro Hirai

    Citation: Respiratory Research 2019 20:77

    Content type: Research

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  42. Exposure to fine particulate matter (PM2.5) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM2.5-induced toxicity may provide ...

    Authors: Juan Li, Hang Li, Haibin Li, Weili Guo, Zhen An, Xiang Zeng, Wen Li, Huijun Li, Jie Song and Weidong Wu

    Citation: Respiratory Research 2019 20:76

    Content type: Research

    Published on:

  43. It is not known if the endogenous surfactant pool available early in life is associated with the RDS clinical course in preterm neonates treated with CPAP. We aim to clarify the clinical factors affecting surf...

    Authors: Roberto Raschetti, Roberta Centorrino, Emmanuelle Letamendia, Alexandra Benachi, Anne Marfaing-Koka and Daniele De Luca

    Citation: Respiratory Research 2019 20:75

    Content type: Research

    Published on:

  44. Pulmonary vascular abnormalities are a characteristic feature of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most important risk factor for COPD. It is believed that its constant exp...

    Authors: Olga Tura-Ceide, Sandra Pizarro, Jéssica García-Lucio, Josep Ramírez, Laureano Molins, Isabel Blanco, Yolanda Torralba, Marta Sitges, Cristina Bonjoch, Victor I. Peinado and Joan Albert Barberà

    Citation: Respiratory Research 2019 20:74

    Content type: Research

    Published on:

  45. Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unk...

    Authors: Joseph Jude, Danielle Botelho, Nikhil Karmacharya, Gao Yuan Cao, William Jester and Reynold A. Panettieri Jr

    Citation: Respiratory Research 2019 20:72

    Content type: Research

    Published on:

  46. Given the broad definition of an acute exacerbation of IPF, it is likely that acute exacerbations are heterogeneous in their aetiology, severity and clinical course. We used pooled data from the INPULSIS® tria...

    Authors: Michael Kreuter, Harald Koegler, Matthias Trampisch, Silke Geier and Luca Richeldi

    Citation: Respiratory Research 2019 20:71

    Content type: Research

    Published on:

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