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  1. Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteogl...

    Authors: Anna-Karin Larsson-Callerfelt, Oskar Hallgren, Annika Andersson-Sjöland, Lena Thiman, Johan Björklund, Josefine Kron, Kristian Nihlberg, Leif Bjermer, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2013 14:21
    Content type: Research Published on:

  2. Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role in the ...

    Authors: Xue-Feng Xu, Ying Lv, Wei-Zhong Gu, Li-Li Tang, Jia-Kai Wei, Li-Yan Zhang and Li-Zhong Du
    Citation: Respiratory Research 2013 14:20
    Content type: Research Published on:

  3. Individuals with deficiencies of pulmonary surfactant protein C (SP-C) develop interstitial lung disease (ILD) that is exacerbated by viral infections including respiratory syncytial virus (RSV). SP-C gene tar...

    Authors: Stephan W Glasser, Albert P Senft, Melissa D Maxfield, Teah L Ruetschilling, John E Baatz, Kristen Page and Thomas R Korfhagen
    Citation: Respiratory Research 2013 14:19
    Content type: Research Published on:

  4. The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographica...

    Authors: Yuan Zhang, Xianqiu Chen, Yang Hu, Shanshan Du, Li Shen, Yifan He, Yuxuan Zhang, Xia Zhang, Huiping Li and Rex C Yung
    Citation: Respiratory Research 2013 14:18
    Content type: Research Published on:

  5. Severe asthma is a heterogeneous disease and the relationship between airway inflammation and airway remodelling is poorly understood. We sought to define sputum mediator profiles in severe asthmatics categori...

    Authors: Dhananjay Desai, Sumit Gupta, Salman Siddiqui, Amisha Singapuri, William Monteiro, James Entwisle, Sudha Visvanathan, Harsukh Parmar, Radhika Kajekar and Christopher E Brightling
    Citation: Respiratory Research 2013 14:17
    Content type: Research Published on:

  6. No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB) in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during ...

    Authors: Simone Accordini, Angelo Guido Corsico, Isa Cerveri, Leonardo Antonicelli, Francesco Attena, Roberto Bono, Lucio Casali, Marcello Ferrari, Alessandro Fois, Pierpaolo Marchetti, Pietro Pirina, Roberta Tassinari, Giuseppe Verlato and Roberto de Marco
    Citation: Respiratory Research 2013 14:16
    Content type: Research Published on:

  7. Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune responses from BECs to RV infection are critical in limi...

    Authors: Katherine J Baines, Alan C-Y Hsu, Melinda Tooze, Lakshitha P Gunawardhana, Peter G Gibson and Peter AB Wark
    Citation: Respiratory Research 2013 14:15
    Content type: Research Published on:

  8. We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might benefit from antioxidant supplementation. This study aim...

    Authors: Hortensia Moreno-Macías, Douglas W Dockery, Joel Schwartz, Diane R Gold, Nan M Laird, Juan J Sienra-Monge, Blanca E Del Río-Navarro, Matiana Ramírez-Aguilar, Albino Barraza-Villarreal, Huiling Li, Stephanie J London and Isabelle Romieu
    Citation: Respiratory Research 2013 14:14
    Content type: Research Published on:

  9. Toll-like receptors (TLRs) on T cells can modulate their responses, however, the extent and significance of TLR expression by lung T cells, NK cells, or NKT cells in chronic obstructive pulmonary disease (COPD...

    Authors: Christine M Freeman, Fernando J Martinez, MeiLan K Han, George R Washko, Jr, Alexandra L McCubbrey, Stephen W Chensue, Douglas A Arenberg, Catherine A Meldrum, Lisa McCloskey and Jeffrey L Curtis
    Citation: Respiratory Research 2013 14:13
    Content type: Research Published on:

  10. Increased airway wall thickness (AWT) and parenchymal lung destruction bothcontribute to airflow limitation. Advances in computed tomography (CT)post-processing imaging allow to quantify these features. The ai...

    Authors: Akkelies E Dijkstra, Dirkje S Postma, Nick ten Hacken, Judith M Vonk, Matthijs Oudkerk, Peter MA van Ooijen, Pieter Zanen, Firdaus A Mohamed Hoesein, Bram van Ginneken, Michael Schmidt and Harry JM Groen
    Citation: Respiratory Research 2013 14:11
    Content type: Research Published on:

  11. The pathogenesis of COPD is complex and remains poorly understood. The European Respiratory Society Study on Chronic Obstructive Pulmonary Disease (EUROSCOP) investigated long-term effects of budesonide; 18% o...

    Authors: Fatemeh Fattahi, Nick H T ten Hacken, Claes-Göran Löfdahl, Machteld N Hylkema, Wim Timens, Dirkje S Postma and Judith M Vonk
    Citation: Respiratory Research 2013 14:10
    Content type: Research Published on:

  12. Mesenchymal stem cells (MSC) are in clinical trials for widespread indications including musculoskeletal, neurological, cardiac and haematological disorders. Furthermore, MSC can ameliorate pulmonary fibrosis ...

    Authors: Khondoker M Akram, Sohel Samad, Monica A Spiteri and Nicholas R Forsyth
    Citation: Respiratory Research 2013 14:9
    Content type: Research Published on:

  13. Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neu...

    Authors: Hikari Koga, Nobuaki Miyahara, Yasuko Fuchimoto, Genyo Ikeda, Koichi Waseda, Katsuichiro Ono, Yasushi Tanimoto, Mikio Kataoka, Erwin W Gelfand, Mitsune Tanimoto and Arihiko Kanehiro
    Citation: Respiratory Research 2013 14:8
    Content type: Research Published on:

  14. Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products...

    Authors: Isham Huizar, Anagha Malur, Janki Patel, Matthew McPeek, Larry Dobbs, Christopher Wingard, Barbara P Barna and Mary Jane Thomassen
    Citation: Respiratory Research 2013 14:7
    Content type: Research Published on:

  15. Reduced gas transfer in patients with pulmonary arterial hypertension (PAH) is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary ...

    Authors: Samar Farha, Daniel Laskowski, Deepa George, Margaret M Park, WH Wilson Tang, Raed A Dweik and Serpil C Erzurum
    Citation: Respiratory Research 2013 14:6
    Content type: Research Published on:

  16. Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it’s role in the inflammatory respons...

    Authors: Etsuko Kurimoto, Nobuaki Miyahara, Arihiko Kanehiro, Koichi Waseda, Akihiko Taniguchi, Genyo Ikeda, Hikari Koga, Hisakazu Nishimori, Yasushi Tanimoto, Mikio Kataoka, Yoichiro Iwakura, Erwin W Gelfand and Mitsune Tanimoto
    Citation: Respiratory Research 2013 14:5
    Content type: Research Published on:

  17. Human leukocyte antigen (HLA)-G is a nonclassical class I antigen with immunomodulatory roles including up-regulation of suppressor T regulatory lymphocytes. HLA-G was recently identified as an asthma suscepti...

    Authors: Steven R White, Dagan A Loisel, Randi Stern, Bharathi Laxman, Timothy Floreth and Bertha A Marroquin
    Citation: Respiratory Research 2013 14:4
    Content type: Research Published on:

  18. Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects...

    Authors: Nicole Pfarr, Christine Fischer, Nicola Ehlken, Tabea Becker-Grünig, Vanesa López-González, Matthias Gorenflo, Alfred Hager, Katrin Hinderhofer, Oliver Miera, Christian Nagel, Dietmar Schranz and Ekkehard Grünig
    Citation: Respiratory Research 2013 14:3
    Content type: Research Published on:

  19. Stromal interaction molecule 1 (STIM1) is a newly discovered Ca2+ sensor on the endoplasmic reticulum which is an indispensable part in the activation of store-operated Ca2+ channels (SOC). Recent studies demonst...

    Authors: Xianhua Hou, Jian Chen, Yongjun Luo, Fuyu Liu, Gang Xu and Yuqi Gao
    Citation: Respiratory Research 2013 14:2
    Content type: Research Published on:

  20. Both chronic hypoxia and allergic inflammation induce vascular remodeling in the lung, but only chronic hypoxia appears to cause PH. We investigate the nature of the vascular remodeling and the expression and ...

    Authors: Daniel J Angelini, Qingning Su, Kazuyo Yamaji-Kegan, Chunling Fan, John T Skinner, Andre Poloczek, Hazim El-Haddad, Chris Cheadle and Roger A Johns
    Citation: Respiratory Research 2013 14:1
    Content type: Research Published on:

  21. Quantifying the improvements in lower limb or quadriceps muscle mass following resistance training (RT), is an important outcome measure in COPD. Ultrasound is a portable, radiation free imaging technique that...

    Authors: Manoj K Menon, Linzy Houchen, Samantha Harrison, Sally J Singh, Michael D Morgan and Michael C Steiner
    Citation: Respiratory Research 2012 13:119
    Content type: Research Published on:

  22. Guaifenesin is a component of medicines used to improve symptoms associated with upper respiratory tract infections. Patient-reported outcome instruments are valuable for evaluating symptom improvements; howev...

    Authors: Helmut Albrecht, Margaret Vernon and Gail Solomon
    Citation: Respiratory Research 2012 13:118
    Content type: Research Published on:

  23. There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of...

    Authors: Kim DG van de Kant, Linda JTM van der Sande, Quirijn Jöbsis, Onno CP van Schayck and Edward Dompeling
    Citation: Respiratory Research 2012 13:117
    Content type: Review Published on:

  24. Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas...

    Authors: Paul Stoll, Urs Wuertemberger, Kai Bratke, Christiana Zingler, J Christian Virchow and Marek Lommatzsch
    Citation: Respiratory Research 2012 13:116
    Content type: Research Published on:

  25. Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstr...

    Authors: Earl S Ford, Anne G Wheaton, David M Mannino, Letitia Presley-Cantrell, Chaoyang Li and Janet B Croft
    Citation: Respiratory Research 2012 13:115
    Content type: Research Published on:

  26. The effectiveness of strategies for treatment of the altered static lung volume and against the development of bronchial hyperreactivity (BHR) following a left ventricular dysfunction (LVD) induced by myocardi...

    Authors: Ferenc Petak, Gergely Albu, Eniko Lele, Maurice Beghetti and Walid Habre
    Citation: Respiratory Research 2012 13:114
    Content type: Research Published on:

  27. Haemophilus influenzae is the most common colonizing bacteria of the bronchial tree in chronic obstructive pulmonary disease (COPD), and positive cultures for this potentially pathogenic microorganism (PPM) has b...

    Authors: Laura Millares, Alicia Marin, Judith Garcia-Aymerich, Jaume Sauleda, José Belda and Eduard Monsó
    Citation: Respiratory Research 2012 13:113
    Content type: Research Published on:

  28. The study aimed at prospectively evaluating the evolution of asthma control in Italy, to evaluate the reasons for lack of asthma control, perceived quality of life (QoL) and association with level of asthma co...

    Authors: Claudio Terzano, Giovanni Cremonesi, Giuseppe Girbino, Eleonora Ingrassia, Serafino Marsico, Gabriele Nicolini and Luigi Allegra
    Citation: Respiratory Research 2012 13:112
    Content type: Commentary Published on:

  29. Prognostic assessment is important for the management of patients with acute pulmonary embolism (APE). Pulmonary Embolism Severity Index (PESI) and simple PESI (sPESI) are new emerged prognostic assessment too...

    Authors: Xiao-Yu Zhou, Su-Qin Ben, Hong-Lin Chen and Song-Shi Ni
    Citation: Respiratory Research 2012 13:111
    Content type: Research Published on:

  30. Docosahexaenoic acid (DHA) and DHA-derived lipid mediators have recently been shown to possess anti-inflammatory and pro-resolving properties. In fact, DHA can down-regulate lipolysaccharide (LPS)-induced acti...

    Authors: Zenglin Liao, Jiajia Dong, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen
    Citation: Respiratory Research 2012 13:110
    Content type: Research Published on:

  31. Relationships between improvements in lung function and other clinical outcomes in chronic obstructive pulmonary disease (COPD) are not documented extensively. We examined whether changes in trough forced expi...

    Authors: Paul W Jones, James F Donohue, Jerry Nedelman, Steve Pascoe, Gregory Pinault and Cheryl Lassen
    Citation: Respiratory Research 2012 12:161
    Content type: Research Published on:

  32. Only 10-15% of smokers develop chronic obstructive pulmonary disease (COPD) which indicates genetic susceptibility to the disease. Recent studies suggested an association between COPD and polymorphisms in CHRNA c...

    Authors: Jing Zhang, Hanssa Summah, Ying-gang Zhu and Jie-Ming Qu
    Citation: Respiratory Research 2012 12:158
    Content type: Research Published on:

  34. Increased pulmonary arterial vascular smooth muscle (PAVSM) cell proliferation is a key pathophysiological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PH). The long-acting β2-ad...

    Authors: Elena A Goncharova, Irene S Khavin, Dmitry A Goncharov and Vera P Krymskaya
    Citation: Respiratory Research 2012 13:109
    Content type: Research Published on:

  35. Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment ...

    Authors: Cheng Yuan, Lin Zhou, Jiyun Cheng, Jingying Zhang, Yue Teng, Mao Huang, Ian M Adcock, Peter J Barnes and Xin Yao
    Citation: Respiratory Research 2012 13:108
    Content type: Review Published on:

  37. An association between innate immunity including Toll-like receptors (TLRs) and COPD is reported recently; TLR4 deficiency in lung can cause emphysema in animals, which is not evident in humans. We analyzed th...

    Authors: Sei Won Lee, Dal Rae Kim, Tae Jung Kim, Jin Ho Paik, Jin-Haeng Chung, Sanghoon Jheon, Jin Won Huh, Jae-Ho Lee and Choon-Taek Lee
    Citation: Respiratory Research 2012 13:106
    Content type: Research Published on:

  38. Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fi...

    Authors: Seung-Ick Cha, Christopher J Ryerson, Joyce S Lee, Jasleen Kukreja, Sophia S Barry, Kirk D Jones, Brett M Elicker, Dong Soon Kim, Feroz R Papa, Harold R Collard and Paul J Wolters
    Citation: Respiratory Research 2012 13:105
    Content type: Research Published on:

  39. Snail is a transcriptional factor which is known to influence the epitheliomesenchymal transition (EMT) by regulating adhesion proteins such as E-cadherin and claudins as well as matrix metalloproteases (MMP).

    Authors: Heta Merikallio, Taina Turpeenniemi-Hujanen, Paavo Pääkkö, Riitta Mäkitaro, Kaarteenaho Riitta, Sirpa Salo, Tuula Salo, Terttu Harju and Ylermi Soini
    Citation: Respiratory Research 2012 13:104
    Content type: Research Published on:

  40. Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a ...

    Authors: Kayoko Shimodaira, Yoichiro Okubo, Eri Ochiai, Haruo Nakayama, Harutaka Katano, Megumi Wakayama, Minoru Shinozaki, Takao Ishiwatari, Daisuke Sasai, Naobumi Tochigi, Tetsuo Nemoto, Tsutomu Saji, Katsuhiko Kamei and Kazutoshi Shibuya
    Citation: Respiratory Research 2012 13:103
    Content type: Research Published on:

  41. Chronic Obstructive Pulmonary Disease (COPD) is defined by post-bronchodilator spirometry. Data on “normal values” come predominantly from pre-bronchodilator spirometry. The effects of this on diagnosis are un...

    Authors: Bernet Kato, Amund Gulsvik, William Vollmer, Christer Janson, Michael Studnika, Sonia Buist and Peter Burney
    Citation: Respiratory Research 2012 13:102
    Content type: Research Published on:

  42. Chronic Obstructive Pulmonary Disease (COPD) is characterized by an enhanced inflammatory response to smoking that persists despite quitting. The resolution of inflammation (catabasis) is a complex and highly ...

    Authors: Aina Noguera, Cristina Gomez, Rosa Faner, Borja Cosio, Ana González-Périz, Joan Clària, Angel Carvajal and Alvar Agustí
    Citation: Respiratory Research 2012 13:101
    Content type: Research Published on:

  43. Lipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease. A therapeutic targeting of this enzyme was ...

    Authors: Zhilong Jiang, Melane L Fehrenbach, Giulia Ravaioli, Blerina Kokalari, Imre G Redai, Steven A Sheardown, Stephen Wilson, Colin Macphee and Angela Haczku
    Citation: Respiratory Research 2012 13:100
    Content type: Research Published on:

  44. Studies have shown that epinephrine release is impaired in patients with asthma. The pregnancy of female rats (dams) with asthma promotes in their pups the differentiation of adrenal medulla chromaffin cells (...

    Authors: Jun-Tao Feng, Xiu-Ming Wu, Xiao-Zhao Li, Ye-Qiang Zou, Ling Qin and Cheng-Ping Hu
    Citation: Respiratory Research 2012 13:99
    Content type: Research Published on:

  45. Therapeutic intervention in the pathophysiology of airway mucus hypersecretion is clinically important. Several types of drugs are available with different possible modes of action. We examined the effects of ...

    Authors: JeanClare Seagrave, Helmut H Albrecht, David B Hill, Duncan F Rogers and Gail Solomon
    Citation: Respiratory Research 2012 13:98
    Content type: Research Published on:

  46. Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP ...

    Authors: Arne Didrik Høiseth, Torbjørn Omland, Tor-Arne Hagve, Pål H Brekke and Vidar Søyseth
    Citation: Respiratory Research 2012 13:97
    Content type: Research Published on:

  47. Usual interstitial pneumonia (UIP), is a necessary feature pathologically or radiologically for the diagnosis of idiopathic pulmonary fibrosis (IPF). The predictive value of transbronchial biopsy (TBB) in iden...

    Authors: Sara Tomassetti, Alberto Cavazza, Thomas V Colby, Jay H Ryu, Oriana Nanni, E Scarpi, Paola Tantalocco, Matteo Buccioli, Alessandra Dubini, Sara Piciucchi, Claudia Ravaglia, Christian Gurioli, Gian Luca Casoni, Carlo Gurioli, Micaela Romagnoli and Venerino Poletti
    Citation: Respiratory Research 2012 13:96
    Content type: Research Published on:

  48. Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general ...

    Authors: Pierachille Santus, Antonio Russo, Enzo Madonini, Luigi Allegra, Francesco Blasi, Stefano Centanni, Antonio Miadonna, Gianfranco Schiraldi and Sandro Amaducci
    Citation: Respiratory Research 2012 13:95
    Content type: Research Published on:

  49. Inbred mouse strains are used in different models of respiratory diseases but the variation of critical respiratory leukocyte subpopulations across different strains is unknown.

    Authors: Holger Hackstein, Andreas Wachtendorf, Sabine Kranz, Jürgen Lohmeyer, Gregor Bein and Nelli Baal
    Citation: Respiratory Research 2012 13:94
    Content type: Research Published on:

  50. Systemic neovascularization of the lung during chronic ischemia has been observed in all mammals studied. However, the proteins that orchestrate the complex interaction of new vessel growth and tunneling throu...

    Authors: Clarke G Tankersley, Aigul Moldobaeva and Elizabeth M Wagner
    Citation: Respiratory Research 2012 13:93
    Content type: Research Published on:
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Respiratory Research

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