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  1. Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive statins. ...

    Authors: AJN Raymakers, D. D. Sin, M. Sadatsafavi, JM FitzGerald, C. A. Marra and L. D. Lynd
    Citation: Respiratory Research 2020 21:118
    Content type: Research Published on:

  2. Targeted lung denervation (TLD), a novel bronchoscopic procedure which attenuates pulmonary nerve input to the lung to reduce the clinical consequences of neural hyperactivity, may be an important emerging tre...

    Authors: Martin L. Mayse, Holly S. Norman, Alexander D. Peterson, Kristina T. Rouw and Philip J. Johnson
    Citation: Respiratory Research 2020 21:117
    Content type: Research Published on:

  4. This study was conducted to evaluate the relationship between nasal resistance in different posture and optimal positive airway pressure (PAP) level. Other potential factors were also assessed for possible inf...

    Authors: Yen-Bin Hsu, Stanley Yung-Chuan Liu, Ming-Ying Lan, Yun-Chen Huang, I-Shiang Tzeng and Ming-Chin Lan
    Citation: Respiratory Research 2020 21:115
    Content type: Research Published on:

  6. High FiO2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E1 (PGE1) can improve oxy...

    Authors: Pengyi Li, Lianbing Gu, Qingming Bian, Jing Tan, Dian Jiao, Fei Wu, Zeping Xu and Lijun Wang
    Citation: Respiratory Research 2020 21:113
    Content type: Research Published on:

  7. Authors: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit
    Citation: Respiratory Research 2020 21:112
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:122

    The original article was published in Respiratory Research 2020 21:27

    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:114

  8. Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number o...

    Authors: Ryan Brown, Sridesh Nath, Alnardo Lora, Ghassan Samaha, Ziyad Elgamal, Ryan Kaiser, Clifford Taggart, Sinéad Weldon and Patrick Geraghty
    Citation: Respiratory Research 2020 21:111
    Content type: Review Published on:

  9. The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective i...

    Authors: Sirous Sadeghian Chaleshtori, Mohammad Reza Mokhber Dezfouli and Massoumeh Jabbari Fakhr
    Citation: Respiratory Research 2020 21:110
    Content type: Review Published on:

  10. The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

    Authors: Liang Chen, Xiudi Han, Yan Li Li, Chunxiao Zhang and Xiqian Xing
    Citation: Respiratory Research 2020 21:109
    Content type: Research Published on:

  11. Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

    Authors: Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese, Carmel B. Nanthakumar, Vikki J. Barrett, Robert B. Good, Sarah Brockbank, Simon Cruwys, Henrik Jessen, Grith Lykke Sorensen, Morten Asser Karsdal, Diana Julie Leeming and Jannie Marie Bülow Sand
    Citation: Respiratory Research 2020 21:108
    Content type: Research Published on:

  12. Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

    Authors: Julie Weidner, Linda Ekerljung, Carina Malmhäll, Nicolae Miron and Madeleine Rådinger
    Citation: Respiratory Research 2020 21:107
    Content type: Research Published on:

  13. In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...

    Authors: Timm Greulich, Julia Tüffers, Sina Mager, Anna Eder, Michael Maxheim, Peter Alter, Bernd Schmeck and Claus F. Vogelmeier
    Citation: Respiratory Research 2020 21:106
    Content type: Research Published on:

  15. Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

    Authors: Nirmal S. Sharma, Grant Vestal, Keith Wille, Kapil N. Patel, Feng Cheng, Srinivas Tipparaju, Sultan Tousif, Mudassir M. Banday, Xin Xu, Landon Wilson, Viswam S. Nair, Casey Morrow, Don Hayes Jr, Andreas Seyfang, Stephen Barnes, Jessy S. Deshane…
    Citation: Respiratory Research 2020 21:104
    Content type: Research Published on:

  16. Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

    Authors: Mariaelena Occhipinti, Matteo Paoletti, James D. Crapo, Barry J. Make, David A. Lynch, Vito Brusasco, Federico Lavorini, Edwin K. Silverman, Elizabeth A. Regan and Massimo Pistolesi
    Citation: Respiratory Research 2020 21:103
    Content type: Research Published on:

  17. In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

    Authors: Yanan Yin, Ganesh Vilas Shelke, Cecilia Lässer, Hjalmar Brismar and Jan Lötvall
    Citation: Respiratory Research 2020 21:101
    Content type: Research Published on:

  18. Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

    Authors: Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko…
    Citation: Respiratory Research 2020 21:100
    Content type: Research Published on:

  19. There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

    Authors: Jing Xu, Tingting Pan, Xiaoling Qi, Ruoming Tan, Xiaoli Wang, Zhaojun Liu, Zheying Tao, Hongping Qu, Yi Zhang, Hong Chen, Yihui Wang, Jingjing Zhang, Jie Wang and Jialin Liu
    Citation: Respiratory Research 2020 21:99
    Content type: Research Published on:

  20. Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...

    Authors: David I. Kasahara and Stephanie A. Shore
    Citation: Respiratory Research 2020 21:98
    Content type: Research Published on:

  21. Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor pro...

    Authors: Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian and Jill A. Poole
    Citation: Respiratory Research 2020 21:97
    Content type: Research Published on:

  22. The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease pr...

    Authors: Jing Gao, Jun-Qiang Liu, Heng-Jun Wen, Hua Liu, Wei-Dong Hu, Xia Han, Chuan-Xing Li and Xiao-Jun Wang
    Citation: Respiratory Research 2020 21:96
    Content type: Letter to the Editor Published on:

  23. It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and ...

    Authors: Xiaomin Dang, Beibei He, Qian Ning, Ya Liu, Jianxin Guo, Gang Niu and Mingwei Chen
    Citation: Respiratory Research 2020 21:95
    Content type: Research Published on:

  24. A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO2/FlO2, and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasi...

    Authors: Hyeontaek Hwang, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Sang-Min Lee
    Citation: Respiratory Research 2020 21:94
    Content type: Research Published on:

  25. COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.

    Authors: Alexander J. Mackay, Konstantinos Kostikas, Nicolas Roche, Stefan-Marian Frent, Petter Olsson, Pascal Pfister, Pritam Gupta, Francesco Patalano, Donald Banerji and Jadwiga A. Wedzicha
    Citation: Respiratory Research 2020 21:93
    Content type: Research Published on:

  26. Macrophage migration inhibitory factor (MIF) has been implicated as a protective factor in the development of bronchopulmonary dysplasia (BPD) and is known to be regulated by MicroRNA-451 (miR-451). The aim of...

    Authors: Margaret Gilfillan, Pragnya Das, Dilip Shah, Mohammad Afaque Alam and Vineet Bhandari
    Citation: Respiratory Research 2020 21:92
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2020 21:121

  27. Idiopathic pulmonary fibrosis (IPF) specific version of St. George’s Respiratory Questionnaire (SGRQ-I) and King’s Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Ole Hilberg, Saher Burhan Shaker, Jesper Rømhild Davidsen and Elisabeth Bendstrup
    Citation: Respiratory Research 2020 21:91
    Content type: Research Published on:

  28. Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obs...

    Authors: Andreas Scherr, Desiree M. Schumann, Meropi Karakioulaki, Léo Franchetti, Werner Strobel, Michael Zellweger, Michael Tamm and Daiana Stolz
    Citation: Respiratory Research 2020 21:90
    Content type: Research Published on:

  30. Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in th...

    Authors: Andrzej S. Swinarew, Arkadiusz J. Stanula, Jadwiga Gabor, Paweł Raif, Jarosław Paluch, Jakub Karpiński, Klaudia Kubik, Hubert Okła, Andrzej Ostrowski, Ewaryst Tkacz, Szymon Skoczyński, Zbigniew Waśkiewicz, Thomas Rosemann, Pantelis T. Nikolaidis and Beat Knechtle
    Citation: Respiratory Research 2020 21:88
    Content type: Research Published on:

  31. Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatme...

    Authors: Henrik Watz, Jens M. Hohlfeld, Dave Singh, Jutta Beier, Zuzana Diamant, Jinming Liu, Shucheng Hua, Khalid Abd-Elaziz, Pascale Pinot, Ieuan Jones and Hanns-Christian Tillmann
    Citation: Respiratory Research 2020 21:87
    Content type: Letter to the Editor Published on:

  32. Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism,...

    Authors: Yipeng Ding, Yixiu Yang, Quanni Li, Qiong Feng, Dongchuan Xu, Cibing Wu, Jie Zhao, Xiaoli Zhou, Huan Niu, Ping He, Jianfang Liu and Hongxia Yao
    Citation: Respiratory Research 2020 21:86
    Content type: Research Published on:

  33. Intraoperative Extracorporeal membrane oxygenation (ECMO) is increasingly being applied as life-support for lung transplantation patients. However, factors associated with this procedure in lung transplantatio...

    Authors: Rong Zhang, Yonghao Xu, Ling Sang, Sibei Chen, Yongbo Huang, Lingbo Nong, Chun Yang, Xuesong Liu, Dongdong Liu, Yin Xi, Weiqun He, Bing Wei, Jianxing He, Yimin Li and Xiaoqing Liu
    Citation: Respiratory Research 2020 21:85
    Content type: Research Published on:

  34. Chronic obstructive pulmonary disease (COPD) is airway inflammation characterized and low daily physical activity. Most pulmonary rehabilitation (PR) programs are often provided to stable patients, but fewer t...

    Authors: Lan-Fang Tung, Sheng-Yeh Shen, Hui-Hsuan Shih, Yen-Ting Chen, Chia-te Yen and Shu-Chuan Ho
    Citation: Respiratory Research 2020 21:84
    Content type: Research Published on:

  35. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The car...

    Authors: Lei Gao, Dan Jiang, Xue-song Wen, Xiao-cheng Cheng, Min Sun, Bin He, Lin-na You, Peng Lei, Xiao-wei Tan, Shu Qin, Guo-qiang Cai and Dong-ying Zhang
    Citation: Respiratory Research 2020 21:83
    Content type: Research Published on:

  36. Diabetes mellitus causes the deterioration of smooth muscle cells and interstitial matrix proteins, including collagen. Collagen and smooth muscle cells are abundant in the lungs, but the effect of diabetes on...

    Authors: Roberta Südy, Álmos Schranc, Gergely H. Fodor, József Tolnai, Barna Babik and Ferenc Peták
    Citation: Respiratory Research 2020 21:82
    Content type: Research Published on:

  37. Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of A...

    Authors: Adrien Carla, Bruno Pereira, Hanifa Boukail, Jules Audard, Nathalie Pinol-Domenech, Manuela De Carvalho, Raiko Blondonnet, Ruoyang Zhai, Dominique Morand, Céline Lambert, Vincent Sapin, Lorraine B. Ware, Carolyn S. Calfee, Julie A. Bastarache, John G. Laffey, Nicole P. Juffermans…
    Citation: Respiratory Research 2020 21:81
    Content type: Study protocol Published on:

  38. Adolescence is a significant period for the gender-dependent development of lung function. Prior studies have shown that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phos...

    Authors: Shadia Khan Sunny, Hongmei Zhang, Faisal I. Rezwan, Caroline L. Relton, A. John Henderson, Simon Kebede Merid, Erik Melén, Jenny Hallberg, S. Hasan Arshad, Susan Ewart and John W. Holloway
    Citation: Respiratory Research 2020 21:80
    Content type: Research Published on:

  39. Chronic respiratory diseases constitute a considerable part in the practice of pulmonologists and primary care physicians; spirometry is integral for the diagnosis and monitoring of these diseases, yet remains...

    Authors: Konstantinos P. Exarchos, Athena Gogali, Agni Sioutkou, Christos Chronis, Sofia Peristeri and Konstantinos Kostikas
    Citation: Respiratory Research 2020 21:79
    Content type: Research Published on:

  40. Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced n...

    Authors: Richard Tuttle, Luca Popescu, Scott Hill, Amber Slanczka, Jeffrey Jankowski, Katherine Barre, Erika Krueger, Desmond Slade, Claire Croutch, Matthew Robben, Zack Mesa, Michael Mesa and Kenneth L. Dretchen
    Citation: Respiratory Research 2020 21:78
    Content type: Research Published on:

  41. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage. Increasing evidence shows that the microbiota plays a rol...

    Authors: Jerome Bouquet, David E. Tabor, Jonathan S. Silver, Varsha Nair, Andrey Tovchigrechko, M. Pamela Griffin, Mark T. Esser, Bret R. Sellman and Hong Jin
    Citation: Respiratory Research 2020 21:77
    Content type: Research Published on:

  42. The mechanism for symptomatic improvement after bronchial thermoplasty (BT) is unclear, since spirometry reveals little or no change. In this study, the effects of BT on airway resistance were examined using t...

    Authors: David Langton, Kim Bennetts, Peter Noble, Virginia Plummer and Francis Thien
    Citation: Respiratory Research 2020 21:76
    Content type: Research Published on:

  43. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement...

    Authors: Toby M. Maher, Juliet K. Simpson, Joanna C. Porter, Frederick J. Wilson, Robert Chan, Rhena Eames, Yi Cui, Sarah Siederer, Simon Parry, Julia Kenny, Robert J. Slack, Jagdeep Sahota, Lyn Paul, Peter Saunders, Philip L. Molyneaux, Pauline T. Lukey…
    Citation: Respiratory Research 2020 21:75
    Content type: Research Published on:

  44. Since December 2019, 2019 novel coronavirus pneumonia emerged in Wuhan city and rapidly spread throughout China and even the world. We sought to analyse the clinical characteristics and laboratory findings of ...

    Authors: Gemin Zhang, Jie Zhang, Bowen Wang, Xionglin Zhu, Qiang Wang and Shiming Qiu
    Citation: Respiratory Research 2020 21:74
    Content type: Research Published on:

  45. Interstitial lung disease (ILD) is a heterogeneous group of mainly chronic lung diseases differing in disease course and prognosis. For most subtypes, evidence on relevance and outcomes of hospitalisations is ...

    Authors: Julia Wälscher, Sabine Witt, Larissa Schwarzkopf and Michael Kreuter
    Citation: Respiratory Research 2020 21:73
    Content type: Research Published on:

  46. Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characteri...

    Authors: Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz and Dave Singh
    Citation: Respiratory Research 2020 21:72
    Content type: Research Published on:

  47. Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, right ventricular hypertrophy and failure. So far no effective treatment exists for this disease; hence...

    Authors: Shanshan Zhang, Xiaoli Liu, Li Li Ge, Kailin Li, Yongchao Sun, Fang Wang, Ying Han, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Chaoyue Xu, Yuan Chen, Ou chen, Zhaohua Zhang and Yun Luan
    Citation: Respiratory Research 2020 21:71
    Content type: Research Published on:

  49. Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior thera...

    Authors: Kevin J. Anstrom, Imre Noth, Kevin R. Flaherty, Rex H. Edwards, Joan Albright, Amanda Baucom, Maria Brooks, Allan B. Clark, Emily S. Clausen, Michael T. Durheim, Dong-Yun Kim, Jerry Kirchner, Justin M. Oldham, Laurie D. Snyder, Andrew M. Wilson, Stephen R. Wisniewski…
    Citation: Respiratory Research 2020 21:68
    Content type: Study protocol Published on:

  50. The use of electronic cigarettes (ECIGs) is increasing, but the impact of ECIG-vapor on cellular processes like inflammation or host defense are less understood. The aim of the present study was to compare the...

    Authors: Christian Herr, Konstantinos Tsitouras, Julia Niederstraßer, Christina Backes, Christoph Beisswenger, Li Dong, Loïc Guillot, Andreas Keller and Robert Bals
    Citation: Respiratory Research 2020 21:67
    Content type: Research Published on:
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