Fig. 2
From: Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma
Upstream module-driving genes in the airways and parenchyma from HDM- compared to PBS-exposed mice. A Airway and B parenchyma compartments from HDM- (n = 10) compared to PBS-exposed mice (n = 12). Bubble plots for each differential gene expression cluster where the median adjusted p-value for all genes within a module was plotted against the median log fold-change, bubble size is representative of the number of genes within a module. ChIP-X Enrichment Analysis 3 (ChEA3) of the top ten predicted transcription factors with significant overlap with our driver gene signatures for A airway and B parenchyma compartments from HDM- (n = 10) compared to PBS-exposed mice (n = 12)