Skip to main content
Fig. 3 | Respiratory Research

Fig. 3

From: d-Limonene inhibits the occurrence and progression of LUAD through suppressing lipid droplet accumulation induced by PM2.5 exposure in vivo and in vitro

Fig. 3

PM2.5 promoted N-SREBP1 translocation into the nucleus, inducing lipid droplet formation. A Western blot analysis showed that N-SREBP1, FASN, ACACA and SCAP proteins were upregulated in H1975 and A549 cells after PM2.5 treatment. B Fluorescent staining showed that N-SREBP1 in the nucleus of A549 and H1975 cells was increased significantly after PM2.5 treatment. C Oil red O staining showed that the production of intracellular lipid droplets was reduced after SREBF1 or FASN was knocked down. D–F After SREBF1 or FASN was knocked down, the migration, colony formation and invasion abilities induced by PM2.5 treatment were inhibited. Scale bar = 50 μm. *P < 0.05; **P < 0.01

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us