Table 1 Demographic and clinical characteristics of 203 lung transplant recipients
Overall (n = 203) | Male (n = 122) | Female (n = 81) | p value | |
|---|---|---|---|---|
Preoperative characteristics | ||||
Age, y | 54 ± 15 | 56 ± 14 | 51 ± 16 | 0.020 |
BMI, kg/m2 | 25 ± 5 | 26 ± 5 | 25 ± 6 | 0.170 |
Primary disease | ||||
Cystic fibrosis or COPD | 80 (39) | 41 (66) | 39 (52) | 0.029 |
Restrictive lung disease | 123 (61) | 81 (34) | 42 (48) | |
Pulmonary vascular disease | 7 (3) | 2 (2) | 5 (6) | |
Lung allocation score | 44 ± 14 | 45 ± 15 | 43 ± 10 | 0.766 |
Condition at time of transplant | ||||
Hospitalized or in ICU | 25 (12) | 15 (12) | 10 (12) | 1.0 |
Not hospitalized | 178 (88) | 107 (88) | 71 (88) | |
Life support before transplanta | 20 (10) | 14 (12) | 6 (7) | 0.472 |
Pulmonary hypertensionb | 150 (74) | 86 (71) | 64 (79) | 0.234 |
Mean PAP, mmHg | 27 (10) | 26 (10) | 28 (9) | 0.194 |
Preoperative immunosuppression agents | 83 (41) | 40 (33) | 43 (53) | 0.005 |
Type of immunosuppression | ||||
Mycophenolate | 12 (14) | 4 (10) | 8 (19) | 0.611 |
Steroid | 43 (52) | 20 (50) | 23 (53) | |
Steroid + mycophenolate | 19 (23) | 10 (25) | 9 (21) | |
Steroid + mycophenolate + tacrolimus | 4 (5) | 3 (8) | 1 (2) | |
Others | 5 (6) | 3 (8)c | 2 (5)d | |
Prior surgery | 47 (23) | 30 (25) | 17 (21) | 0.612 |
Prior cardiac surgery | 4 (2) | 3 (2) | 1 (1) | 1.0 |
Prior lung surgerye | 36 (18) | 24 (20) | 12 (15) | 0.45 |
Prior lung transplant | 3 (1) | 2 (2) | 1 (1) | 1.0 |
Donor characteristics | ||||
Age, y | 35 ± 13 | 35 ± 13 | 36 ± 13 | 0.587 |
Extended criteria donorf | 80 (39) | 47 (39) | 33 (41) | 0.865 |
Ever smoked | 107 (53) | 70 (57) | 37 (46) | 0.136 |
Donor sex | ||||
Male | 127 (63) | 96 (79) | 31 (38) | < 0.001 |
Female | 86 (37) | 26 (21) | 50 (62) | |
Donation after circulatory death | 11 (5) | 6 (5) | 5 (6) | 0.710 |
Ex vivo lung perfusion | 27 (13) | 13 (11) | 14 (17) | 0.250 |
Chest radiography findings | ||||
Not abnormal | 120 (60) | 73 (60) | 47 (58) | 0.870 |
Abnormal single lung | 39 (19) | 22 (18) | 17 (21) | |
Abnormal both lungs | 44 (22) | 27 (22) | 17 (21) | |
Respiratory secretions | ||||
None or scantg | 143 (72) | 89 (74) | 54 (69) | 0.180 |
Thick but clear | 52 (26) | 28 (23) | 24 (31) | |
Repooling | 3 (2) | 3 (3) | 0 (0) | |
Bronchoscopy findingsh | ||||
Not abnormal | 136 (69) | 88 (73) | 48 (62) | 0.257 |
Abnormali single lung | 22 (11) | 11 (9) | 11 (14) | |
Abnormal both lungs | 36 (18) | 18 (15) | 18 (23) | |
Abnormal anatomy/other lesions | 4 (2) | 3 (3) | 1 (1) | |
Operative details | ||||
Type of transplant | ||||
Single | 42 (21) | 27 (22) | 15 (19) | 0.656 |
Bilateral | 161 (79) | 95 (78) | 66 (82) | |
Type of intraoperative support | ||||
Off-pump | 47 (23) | 31 (25) | 16 (20) | 0.443 |
CPB | 124 (61) | 71 (58) | 53 (65) | |
Modified bypass | 18 (9) | 13 (11) | 5 (6) | |
ECMO | 14 (7) | 7 (6) | 7 (9) | |
Total ischemic time, min | 339 ± 136 | 336 ± 124 | 343 ± 153 | 0.673 |
Units of RBC | ||||
< 2 | 115 (57) | 74 (61) | 41 (51) | 0.086 |
2–5 | 72 (35) | 36 (30) | 36 (44) | |
6–10 | 12 (6) | 10 (8) | 2 (2) | |
> 10 | 4 (2) | 2 (2) | 2 (2) | |
Total intraoperative fluid volume, mL | 3201 ± 1837 | 3372 ± 2038 | 2943 ± 1450 | 0.215 |
Type of intraoperative fluidsj | ||||
Colloids | 31 | 19 | 12 | 0.713 |
Crystalloids | 1 | 1 | 0 | |
Combination | 170 | 102 | 68 | |