From: Smoking-associated increase in mucins 1 and 4 in human airways
Factor | Airway cell phenotype | Demographic association |
---|---|---|
MUC1 | Basal cell | ↑ Smokers and Chronic bronchitis Correlated negatively with lung functions in male Smokers Correlated positively with pack-years |
MUC4 | Goblet cells | ↑ Smokers |
EGFR1 | Basal cells | No change |
EGFR2 | Basal and ciliated cells | ↑ Healthy Correlated positively with lung functions Correlated negatively with pack-years and current cigarette consumption |