Skip to main content

A biomarker basing on radiomics for the prediction of overall survival in non–small cell lung cancer patients



This study aimed at predicting the survival status on non-small cell lung cancer patients with the phenotypic radiomics features obtained from the CT images.


A total of 186 patients’ CT images were used for feature extraction via Pyradiomics. The minority group was balanced via SMOTE method. The final dataset was randomized into training set (n = 223) and validation set (n = 75) with the ratio of 3:1. Multiple random forest models were trained applying hyperparameters grid search with 10-fold cross-validation using precision or recall as evaluation standard. Then a decision threshold was searched on the selected model. The final model was evaluated through ROC curve and prediction accuracy.


From those segmented images of 186 patients, 1218 features were obtained via feature extraction. The preferred model was selected with recall as evaluation standard and the optimal decision threshold was set 0.56. The model had a prediction accuracy of 89.33% and the AUC score was 0.9296.


A hyperparameters tuning random forest classifier had greater performance in predicting the survival status of non-small cell lung cancer patients, which could be taken for an automated classifier promising to stratify patients.


Lung cancer, one of the highest risky cancers, is the leading cause of cancer death with a high mortality rate of 82.3% in 5 years after diagnosis (National Cancer Institute). [Noone AM, Howlader N, Krapcho M, et al. SEER Cancer Statistics Review, 1975–2015,] Non-small cell lung cancer is a subtype lung cancer, which accounts for 85% among lung cancers [1]. The 5-year survival rate decreases dramatically as the cancer entering advanced, from 40% for stage I to only 1% for stage IV [2, 3]. It was reported that CT texture analysis could be helpful to further classification of treatment as it provided information on the intratumor heterogeneity [4] which might be the reason for disparate outcomes of patients. Thibaud P. Coroller and etc. used 7 radiomic features to predict pathological response after chemoradiation [5].

In the past 10 years, medical digital image analysis has grown dramatically as advancement of the pattern recognition tools and increase of the data collection. Radiomics offers unlimited imaging biomarkers which are promising to help cancer detection, prognosis and prediction of treatment response [6, 7]. With the high-throughput computing, it’s possible to quickly extract various quantitative features from digital images such as MRI and CT. Since cancers are more likely to be temporal and spatial heterogeneous, the use of biopsy might be limited. Furthermore, medical digital imaging could give a whole picture of the tumor shape, texture and volume, and it is also a noninvasive way to get comprehensive tumor information [8]. Some researches indicated that there was a relationship between radiomic features and tumor grades, histology, metabolism, and patient survival and clinical outcomes [9,10,11]. Kitty Huang et al. also found high risk CT features were significantly associated with local recurrence [12]. Chintan et al. studied the prognostic characteristics of radiomic features between lung cancer and head & neck cancer and found association among 11–13 features and prognosis, histology and stage [13]. Jiangdian et al. investigated the prognostic and predictive ability of phenotypic CT features in non-small cell lung cancer patients and reported an overall clinical stage prediction accuracy of 80.33% [14]. Those previous studies have shown that medical image analysis has a promising ability in improving cancer diagnosis, detection, prognostic prediction on oncology [8].

With those antecedent studies, radiomics displayed its hopeful and cost-effective potential in the area of precision oncology. Even though there have been already numerous researches on the prediction of cancer diagnosis or stage classification, most of them used default parameter or manual selection which might not efficient enough. Most of the time default parameters could give us great result, but the ability of the model would be maximized by parameters optimization when we conduct the training stage [15]. This study intended to construct an automatic grid search [16] hyper-parameters tuning classifier to make detections on the survival status of non-small cell lung cancer patients based on the radiomics features. The dataset was randomized into training set and validation set. A random forest classifier with hyperparameters tuning was used to make classification of survival status of non-small cell lung cancer patients in training set. The model was assessed on the validation data by ROC curve as well as the prediction accuracy.


Data sets

The study included 186 non-small cell lung cancer (NSCLC) patients from two merged datasets R01 and AMC. The patient characteristics and CT images were obtained from the cancer imaging archive (TCIA) database ( Clinical data of all 186 NSCLC patients are provided in Table 1, including the gender, smoking history, histology, treatment, and overall survival data. Additional file 1: Table S1 shows detailed staging information.

Table 1 Demographic characteristics

Feature extraction

One thousand, two hundred eighteen tumor characteristics were quantified by extracted features from the lesion segmented from patients’ CT images. The radiomic features can be categorized into four types such as intensity, shape, texture and wavelet. An open-source package in Python, Pyradiomics was used for various features extraction from CT images [17]. A list of 50 quantitative features including first order features, shape features, Gray Level Size Zone Matrix (GLSZM) features, Features Gray Level Run Length Matrix (GLRLM) features and etc. were extracted. The shape descriptors were extracted from the label mask and also not associated with gray value.

Data balance and data splitting

Extracted features were then weighted differently as a result of data balancing. In machine learning, algorithms assume the distributions of groups are similar. In practice, when the disproportion of classes happens, the learning algorithms tend to be biased towards the majority class. But in this study, we are more interested in the minority class with more adverse events take place [18]. Due to sample imbalance (the number of being alive is much less than that of being dead), rather than simply applying over-sampling with replacement for data balance, we conducted a synthetic minority over-sampling (SMOTE) method to increase the size of the minority group. SMOTE can be used when the number of the category is larger than 6 since it generated the new examples by taking samples of the feature space for the target class and its 5 nearest neighbors. SMOTE has an advantage of making the decision region of the minority class more general [19, 20]. The final size of the dataset was n = 298. Because the minority group was oversampled thus the dataset was randomized into training set (n = 223) and validation set (n = 75). The distribution of being alive and dead between training and validation set was also plotted.

Classifier construction

Based on the radiomics features, we aimed to build a radiomics-based survival status prediction model using random forest classifier and hyperparameters tuning in Python [21]. Random forest creates multiple decision trees by randomly choosing subsets of features to make the classification based on the mode (for classification) or the mean (for regression) from all the smaller trees [22, 23]. It has the advantage of being less vulnerable to overfitting problem compared to decision-trees. A generic random forest classifier was constructed first. Parameter estimation using grid search with 10-fold cross-validation was applied to the training data for parameters tunings such as the number of features to consider for the best split (max_feature), the number of trees in the forest (n_estimators), the maximum depth of the tree (max_depth), the minimum number of samples required to split an internal node (min_sample_split). Precision and recall score were used as evaluation standard for parameters tuning respectively. The two best models with different optimal hyperparameters can be acquired by the top mean precision or recall score respectively. The final preferred model was selected by comparing their performance on the validation data.

Decision threshold adjustment

Instead of directly adopting the absolute predictions, this study also applied for decision value tuning to balance the trade-off between precision and recall. A function of decision values was used to determine the decision threshold of the chosen model to maximize the precision with high recall.

Radiomics model assessment

Model performance was evaluated in terms of the operator characteristic curve (ROC), the area under the curve (AUC) and accuracy, which could quantify the prediction performance of the classifier model.


Class distribution

The class distribution of each class before (Fig. 1a) and after oversampling (Fig. 1b) were presented. It was obvious that after SMOTE method, the number of patient being dead was similar to the number of those being alive. To be note, the sample size after oversampling was 298.

Fig. 1
figure 1

Survival Status Distribution of Patients. a Before oversampling. b After oversampling. X axis is the survival status of the patients: the blue bar represents the alive group and the orange bar represents dead group; Y axis is the number of patients in each survival group

Construction of the survival status prediction model

The construction of the classifier was conducted using a training set consisting of 223 patients with different survive status of NSCLC. Random forest and automatic parameters tuning were applied on the training data to obtain the optimal model. The partial results can be seen in Tables 2 and 3. The confusion matrixes of parameter tuning based on different evaluation standards could be seen in Fig. 2. Comparing the performance of these two models on the validation data, it could draw a conclusion that the model obtained based on recall standard outperformed slightly better than that of precision (The number of correct prediction was slightly larger and false negative was less). The final random forest classifier was constructed using the parameters: ‘max_depth’: 5, ‘max_features’: 20, ‘min_samples_split’: 3 and ‘n_estimators’: 100. Figure 3 displayed the fifty most important features generated in the random forest by Gini importance. As can be seen from the plot, two large area low gray level emphasis features ranked first and second respectively as the most important features in the prediction model but this did not mean that other features were much less important. Since when there were multiple correlated features, once a feature was selected the extent to which other features could lead to impurity decreasing dramatically.

Table 2 Model ranking based on mean precision score
Table 3 Model Ranking Based on Mean Recall Score
Fig. 2
figure 2

Confusion Matrix of Parameter Tuning Based on Different Evaluation. a Based on precision. b Based on recall. The horizontal line means the number of predicted in each group; the vertical line means the actual number of each survival group. The leading diagonal represents correct prediction; the minor diagonal represents incorrect prediction

Fig. 3
figure 3

Fifty Features with Top Gini Importance Values. X axis is the name of features and Y axis represents the Gini-importance score

Figure 4 listed radiology images from separate body sections of three samples which were chosen randomly and all had certain information and features, such as histology, survival status, first order feature, GLSZM feature and etc. The survival status of (A) was alive, while that of (B) and (C) was dead. In common clinical diagnosis, researchers can make predictions based on the morphology of the lesions. As we can see through picture (A) and (B), size of tumor of (B) was significantly larger than that of (a), and clinicians with few experience could easily make difference of similar cases. However, once there was no distinguishing feature in the radiology images, clinicians hardly could diagnose the illness by naked eye. Through a set of comparison, this study found that a small part of image features had greater ability in prognosis. As a result, features extracted from radiology images were needed for further prognosis. Take (a) and (c) as an example, they are very similar in shape and size, whilst as shown in Table 4, difference in some of their features, like original_glszm_Large Area Low Gray Level Emphasis, wavelet.LLH_glszm_Large Area Low Gray Level Emphasis, wavelet. HHH_glcm_Cluster Prominence, wavelet.LLL_glszm_Large Area Emphasis and log.sigma. AreLowGrayLevelEmphasis is remarkable.

Fig. 4
figure 4

The Radiological Images of Three Certain Samples. a-c The patients’ living statuses from (a-c) are Alive, Dead, Dead

Table 4 Basic information and the value of certain features of three cases

Decision threshold adjustment

After deciding the random forest classifier, we searched for the decision threshold for a trade-off between precision and recall. The default decision threshold in random forest was 0.5. Figure 5 showed precision and recall as a function of decision values, where x represented threshold value and y was the score of precision or recall. The optimal decision threshold was obtained as 0.56 from the intersection point and the precision of the model achieved nearly 90% when recall was around 90%, which was further verified by the precision and recall curve as well as the confusion matrix in Fig. 6.

Fig. 5
figure 5

Precision and Recall Score as a Function of Decision Values. Blue dashed line: precision score; Green line: recall score. Y axis in the score value and X axis is decision threshold value. The intersection of the two curves are the optimal point where the trade-off of precision and recall is achieved

Fig. 6
figure 6

Precision and Recall with the Determined Decision Threshold. a Precision and Recall Curve (This curve shows how recall and precision changes as the decision threshold value changes. The triangle represents the decision threshold we chose). b Confusion Matrix. The horizontal line means the number of predicted in each group; the vertical line means the actual number of each survival group. The leading diagonal represents correct prediction; the minor diagonal represents incorrect prediction

Performance of Radiomics prediction model

The performance of the classifier constructed was validated according to the receiver operating characteristic (ROC) metrics in the validation set consisting 42 patients. Figure 7 presented the performance results (AUC: area under the ROC curve) obtained in the validation set for the radiomics model. The prediction accuracy was 89.33% (The percentage of correct classification). The AUC score for this model was 0.9296, which meant the model had a great ability of predicting being alive or being dead.

Fig. 7
figure 7

The ROC curve for Random Forest Model Performance on the Validation Data. X axis represents false positive rate (\( \frac{\mathrm{FP}}{\mathrm{TN}+\mathrm{FP}} \)) and Y axis is true positive rate (\( \frac{\mathrm{TP}}{\mathrm{TP}+\mathrm{FN}} \)). The diagonal dashed line means random prediction


Radiomics has gained great attention as a potential method to promote personal medicine. Its image signatures derived from digital images are promising to help diagnostics and prognostics [24]. It has been shown that features such as texture, shape and intensity had prognostic power in independent data of lung and head-and-neck cancer patients since they were able to capture the intratumor heterogeneity [25]. Applying machine learning techniques on the output data from radiomics has also become a hot topic in oncology, personalized medicine and computer aided diagnosis since its compatibility with the big data generated from digital images [26].

This study intended to predict the non-small cell lung cancer survival status with radiomics features. A total of 1218 features were obtained after feature derivation using Pyradiomics. And those features captured the information about tumor shape, intensity and texture. Data imbalance is always a common problem in classification problem since most interested events like disease, network intrusion and etc. are rare. When sample size is large enough, slight or medium imbalance is not a big problem for training since there is enough information for learning from the minority class. However, when sample size is small, especially for decision tree the leaves that predict the minority class are likely to be pruned [27]. Thus, in this study, a SMOTE oversampling method was necessary to decrease the training fit error. The model was trained with automatic hyperparameters tuning aiming to make use of the best potential of our model. One common problem with hyperparameter tuning is overfitting, which means that the model performs well on the training data but poorly on the test data. This issue can be amended by using cross-validation where the model performance is evaluated by averaging k models. This study skipped the part of feature selection for two reasons: one was that the sample feature ratio was not low to introduce overfitting and another one was that random forest with parameters tuning was powerful since it optimized the number of tress and selected the best feature at each node. The final result of our study also proved that the model without feature selection had a great generalization on the test data.

Moreover, we studied how the adjustment of decision values impacted the precision and accuracy because a good classification model was not only evaluated on the accuracy. Precision and recall are further standards for model evaluation but there is a trade-off between them. Precision decreases as recall increases [28]. For survival status prediction, it is important to differentiate the death to stratify the patient into high risk group automatically. Thus, it might be more cost expensive to misidentify the high-risk patients. Without further test data validation, the result after decision threshold adjustment could be optimistic. However, this study gave a reference for the decision threshold of a non-small cell patient not being alive based on the radiomic feature. This may indicate that radiomics is promising into automatic computer aided patient risk stratification in a non-invasive way. For hyperparameters tuning, this study used grid search, which performed well in low dimensional space. When the dimension space is large or unknown, random search could be considered [2].

Despite of the satisfactory model performance, the study had a few limitations. First, since all training and testing data were acquired from one study, it may not be generalized to all cases [29] with a more heterogeneous dataset, and the accuracy might be lower than the current study. The extents to which the data we used are representative to the real situation also affect how well the trained model could perform in the practical use. Thus, different CT images from different sources are needed to construct a more rigorous and general classification model. The second limitation of the study is disproportion of patients at different disease stages. According to Table 2, the number of people with specific characteristic was far more than the rest, which means patient with a certain stage of the cancer might have more images or more pathologic images. For instance, there were 154 Adenocarcinoma patients, 29 Squamous cell carcinoma patients, and 3 not otherwise specified (NOS) patients.

For future research, more data from diverse patients’ background, different databases, and multiple image modalities should be utilized for further testing and validation. Other mathematical model can be developed to improve feature extraction. Our model can be adopted to improve the performance of classifier. The most relevant features can provide useful information for future exploration to develop a better detection method. Also, with larger dataset, different classification criteria can be tuned according to the different types of lung cancer and disease stages.


To conclude, this study intended to construct a survival status classifier with automatic hyperparameters tuning. In order to optimize classification outcomes, the tuning of decision threshold can serve as a reference for future work. Our classification methods has the potential to contribute to a survival prediction model, which is beneficial to better palliative care and treatment decision.



Area under the curve


Gray Level Run Length Matrix


Gray Level Size Zone Matrix


Non-small cell lung cancer


Receiver operating characteristic


Synthetic minority over-sampling


The cancer imaging archive


  1. 1.

    Parmar C, Leijenaar RTH, Grossmann P, Rios Velazquez E, Bussink J, Rietveld D, Rietbergen MM, Haibe-Kains B, Lambin P, Aerts HJWL. Radiomic feature clusters and prognostic signatures specific for lung and head & neck cancer. Sci Rep. 2015;5:11044.

    Article  PubMed Central  Google Scholar 

  2. 2.

    Song J, Liu Z, Zhong W, Huang Y, Ma Z, Dong D, Liang C, Tian J. Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis. Sci Rep. 2016;6:38282.

  3. 3.

    Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359:1367-80.

    CAS  Article  PubMed Central  Google Scholar 

  4. 4.

    Cetin K, Ettinger DS, Hei Y, O’Malley CD. Survival by histologic subtype in stage IV nonsmall cell lung cancer based on data from the surveillance, epidemiology and end results program. Clin Epidemiol. 2011;3:139–48.

    Article  PubMed Central  Google Scholar 

  5. 5.

    Miles KA. How to use CT texture analysis for prognostication of non-small cell lung cancer. Cancer Imaging. 2016;16:10.

    Article  PubMed Central  Google Scholar 

  6. 6.

    Xu X, Huang Z, Graves D, Pedrycz W. A clustering-based graph Laplacian framework for value function approximation in reinforcement learning. IEEE Trans Cybern. 2014;44:2613–25.

    Article  PubMed Central  Google Scholar 

  7. 7.

    Bergstra J, Bengio Y. Random search for hyper-parameter optimization. J Mach Learn Res. 2012;13:281–305.

    Google Scholar 

  8. 8.

    Gillies RJ, Kinahan PE, Hricak H. Radiomics: images are more than pictures, they are data. Radiology. 2016;278:563–77.

    Article  Google Scholar 

  9. 9.

    Leijenaar RT, Carvalho S, Velazquez ER, van Elmpt WJ, Parmar C, Hoekstra OS, Hoekstra CJ, Boellaard R, Dekker AL, Gillies RJ. Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol. 2013;52:1391–7.

    CAS  Article  PubMed Central  Google Scholar 

  10. 10.

    Kazachkina S, Balakhonova T, Lupanov V, Pogorelova O, Rogoza A, Naumov V. High quality machine-robust image features: identification in nonsmall cell lung cancer computed tomography images. BMC Health Serv Res. 2015;15:1–10.

    Article  Google Scholar 

  11. 11.

    Alic L, Niessen WJ, Veenland JF. Quantification of heterogeneity as a biomarker in tumor imaging: a systematic review. PLoS One. 2014;9:e110300.

    Article  PubMed Central  Google Scholar 

  12. 12.

    Segal E, Sirlin CB, Ooi C, Adler AS, Gollub J, Chen X, Chan BK, Matcuk GR, Barry CT, Chang HY. Decoding global gene expression programs in liver cancer by noninvasive imaging. Nat Biotechnol. 2007;25:675.

    CAS  Article  PubMed Central  Google Scholar 

  13. 13.

    Hui L, Zhu Y, Burnside ES, Drukker K, Hoadley KA, Cheng F, Conzen SD, Whitman GJ, Sutton EJ, Net JM. MR imaging Radiomics signatures for predicting the risk of breast Cancer recurrence as given by research versions of MammaPrint, Oncotype DX, and PAM50 gene assays. Radiology. 2016;281:152110.

    Google Scholar 

  14. 14.

    Huang K, Senthi S, Palma DA, Spoelstra FO, Warner A, Slotman BJ, Senan S. High-risk CT features for detection of local recurrence after stereotactic ablative radiotherapy for lung cancer. Radiother Oncol J Eur Soc Ther Radiol Oncology. 2013;87:S204.

    Google Scholar 

  15. 15.

    Fried DV, Tucker SL, Zhou S, Liao Z, Mawlawi O, Ibbott G, Court LE. Prognostic value and reproducibility of pretreatment CT texture features in stage III non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;90:834–42.

    Article  PubMed Central  Google Scholar 

  16. 16.

    Coroller TP, Agrawal V, Narayan V, Hou Y, Grossmann P, Lee SW, Mak RH, Aerts HJ. Radiomic phenotype features predict pathological response in non-small cell lung cancer. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2016;119:480–6.

    Article  Google Scholar 

  17. 17.

    Jjm VG, Fedorov A, Parmar C, Hosny A, Aucoin N, Narayan V, Rgh BT, Fillion-Robin JC, Pieper S, Hjwl A. Computational Radiomics system to decode the radiographic phenotype. Cancer Res. 2017;77:e104.

    Article  Google Scholar 

  18. 18.

    Krawczyk B. Learning from imbalanced data: open challenges and future directions. Prog Artif Int. 2016;5:1–12.

    Article  Google Scholar 

  19. 19.

    Chawla NV, Bowyer KW, Hall LO, Kegelmeyer WP. SMOTE: synthetic minority over-sampling technique. J Artif Intell Res. 2002;16:321–57.

    Article  Google Scholar 

  20. 20.

    Lemaitre G, Nogueira F, Aridas CK. Imbalanced-learn: a python toolbox to tackle the curse of imbalanced datasets in machine learning. J Mach Learn Res. 2017;18(1):559–63.

    Google Scholar 

  21. 21.

    Pedregosa F, Gramfort A, Michel V, Thirion B, Grisel O, Blondel M, Prettenhofer P, Weiss R, Dubourg V, Vanderplas J. Scikit-learn: machine learning in Python. J Mach Learn Res. 2012;12:2825–30.

    Google Scholar 

  22. 22.

    Quadrianto N, Ghahramani Z. A very simple safe-Bayesian random Forest. IEEE Trans Pattern Anal Mach Intell. 2015;37:1297–303.

    Article  PubMed Central  Google Scholar 

  23. 23.

    Liu X, Song M, Tao D, Liu Z, Zhang L, Chen C, Bu J. Random forest construction with robust semisupervised node splitting. IEEE Trans Image Process. 2015;24:471–83.

    Article  PubMed Central  Google Scholar 

  24. 24.

    Lambin P, Leijenaar RTH, Deist TM, Peerlings J, Jong EECD, Timmeren JV, Sanduleanu S, Larue RTHM, Even AJG, Jochems A. Radiomics: the bridge between medical imaging and personalized medicine. Nat Rev Clin Oncol. 2017;14:749.

    Article  Google Scholar 

  25. 25.

    Aerts HJWL, Velazquez ER, Leijenaar RTH, Parmar C, Grossmann P, Cavalho S, Bussink J, Monshouwer R, Haibekains B, Rietveld D. Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun. 2014;5:4006.

    CAS  Article  PubMed Central  Google Scholar 

  26. 26.

    Parmar C, Grossmann P, Bussink J, Lambin P, Aerts HJ. Machine learning methods for quantitative Radiomic biomarkers. Sci Rep. 2015;5:13087.

    CAS  Article  PubMed Central  Google Scholar 

  27. 27.

    SUN Y, AKC WONG, MS KAMEL. Classification of imbalanced data: a review. Int J Pattern Recognit Artif Intell. 2009;23:687–719.

    Article  Google Scholar 

  28. 28.

    Davis J, Goadrich M. The relationship between Precision-Recall and ROC curves. In ICML '06 : Proceedings of the International Conference on Machine Learning. New York: 2006. p. 233-40.

  29. 29.

    Yu KH, Zhang C, Berry GJ, Altman RB, Ré C, Rubin DL, Snyder M. Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features. Nat Commun. 2016;7:12474.

    CAS  Article  PubMed Central  Google Scholar 

Download references


This work was supported by Yunnan Provincial Health Science and Technology Project (2009NS102, 2010NS027, 2011WS0042 & 2012WS0017) and Scientific Research Projects of Research Institutes in Yunnan Medical and Health Units (2017NS037).

Availability of data and materials

The patient characteristics and CT images were obtained from the cancer imaging archive (TCIA) database, which is a public database with no patient identification, institutional review board approval is not required for this data set.

Author information




Substantial contribution to the conception and design of the work: BH + JYP; Analysis and interpretation of the data: DH + ZGZ; Drafting the manuscript: BH + YMJ; Revising the work critically for important intellectual content: WZ; Collection of grants: WZ; Final approval of the work: all authors. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Wei Zhao.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

The authors agree to publication.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Additional file

Additional file 1:

Table S1. Demographic Information of the patients. (DOCX 15 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

He, B., Zhao, W., Pi, JY. et al. A biomarker basing on radiomics for the prediction of overall survival in non–small cell lung cancer patients. Respir Res 19, 199 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Non-small cell lung cancer
  • Radiomics
  • CT
  • Random forest
  • Survival status