Table 2 Potential Pharmacological Therapies to Reduce ASMC Migration

Corticosteroids [17, 88]

• Fluticasone

• Dexamethasone

• Budenoside

• Fluticasone and Dexamethasone shown to inhibit PDGF-stimulated ASMC migration in vitro [17]; promote inhibitory effect of Salmeterol on PDGF-stimulated ASMC migration in vitro [17]

• Treatment of asthmatics with combined Budenoside and Formoterol reduced myofibrolasts in airway submucosa [88]

Beta-Agonist [17, 88]

• Salmeterol

• Formoterol

• Inhibition of PDGF-stimulated ASMC migration in vitro [17]

• Treatment of asthmatics with combined Budenoside and Formoterol reduced myofibrolasts in airway submucosa [88]

Adenylyl Cyclase Analogue [17]

• Forkskolin

• Inhibition of PDF-induced ASMC migration in vitro [17]

PDE₄ Inhibitor [87]

• Cilomolast

• Inhibition of non-PDGF stimulated ASMC migration in vitro [87]

CysLT Receptor Antagonist [16]

• Montelukast

• Priming effect of LTE4 on PDGF-induced ASMC migration was inhibited following treatment with Montelukast in vitro [16]

DP₂/CRTH₂ Receptor Antagonist [16]

• BWA868C

• Inhibition of PGD₂-stimulated ASMC migration in vitro [16]

PPAR Agonist [110]

• Ciglitazone

• 15-deoxy-D12, 14-prostaglandin J2

• WY-14643

• Inhibition of PDF-induced ASMC migration in vitro [110]