Skip to main content

Table 2 Potential Pharmacological Therapies to Reduce ASMC Migration

From: Regulation of human airway smooth muscle cell migration and relevance to asthma

Therapies Summary of findings
Corticosteroids [17, 88]
• Fluticasone
• Dexamethasone
• Budenoside
• Fluticasone and Dexamethasone shown to inhibit PDGF-stimulated ASMC migration in vitro [17]; promote inhibitory effect of Salmeterol on PDGF-stimulated ASMC migration in vitro [17]
• Treatment of asthmatics with combined Budenoside and Formoterol reduced myofibrolasts in airway submucosa [88]
Beta-Agonist [17, 88]
• Salmeterol
• Formoterol
• Inhibition of PDGF-stimulated ASMC migration in vitro [17]
• Treatment of asthmatics with combined Budenoside and Formoterol reduced myofibrolasts in airway submucosa [88]
Adenylyl Cyclase Analogue [17]
• Forkskolin
• Inhibition of PDF-induced ASMC migration in vitro [17]
PDE4 Inhibitor [87]
• Cilomolast
• Inhibition of non-PDGF stimulated ASMC migration in vitro [87]
CysLT Receptor Antagonist [16]
• Montelukast
• Priming effect of LTE4 on PDGF-induced ASMC migration was inhibited following treatment with Montelukast in vitro [16]
DP2/CRTH2 Receptor Antagonist [16]
• BWA868C
• Inhibition of PGD2-stimulated ASMC migration in vitro [16]
PPAR Agonist [110]
• Ciglitazone
• 15-deoxy-D12, 14-prostaglandin J2
• WY-14643
• Inhibition of PDF-induced ASMC migration in vitro [110]