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Table 3 Multivariate models of association of GDF-15 with CAC score among different subgroups of COPDGene participants with COPD

From: GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

 

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Female participants (n = 327)

Participants without diabetes (n = 634)

Participants not currently smoking (n = 487)

Participants with no walking limitation (n = 304)

GDF-15 level (in tertiles)

 Lower tertile

Ref.

Ref.

Ref.

Ref.

 Intermediate tertile

2.36 (0.84, 6.64)

1.95 (0.99, 3.84)

1.40 (0.66, 2.98)

1.48 (0.57, 3.87)

 Higher tertile

4.56 (1.62, 12.8)

4.00 (2.06, 7.78)

2.41 (1.13, 5.12)

3.76 (1.63, 10.4)

  1. All entries represent risk ratio of being in the higher group of CAC and its 95% CI, based on multinomial logistic regression models
  2. All models additionally adjusted for race, GOLD spirometry stage, pack-years smoked, chronic bronchitis symptoms, history of exacerbations, and co-morbidities (asthma, GERD, mobility-related diseases)
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Respiratory Research

ISSN: 1465-993X

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