Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus
© Veith et al.; licensee BioMed Central Ltd. 2014
Received: 20 February 2014
Accepted: 20 July 2014
Published: 5 August 2014
Surfactant protein A has been shown to enhance opsonization and clearance of Staphylococcus aureus in vitro. Here, the phagocytosis of alveolar S. aureus was investigated in vivo using intravital microscopy. Fluorescence labelled S. aureus Newman cells were intratracheally administered to anesthetized mice and the alveolar surface was observed for fifteen minutes. Confirming previously reported in vitro data, surfactant protein A-deficient mice showed a significantly reduced uptake of bacteria compared to wild-type mice.
The authors thank Ann Soether for editing the language. This study was supported by a grant of the German Ministry for Education and Research (BMBF) #01 KI 070103 and by a grant of the Deutsche Forschungsgemeinschaft (DFG) SFB-TR 84, TP C06.
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