Figure 1

CpG ODN protect mice from lethal BLM-induced lung injury. 0.05 U of BLM was delivered into the lungs of C57BL/6 mice via the intra-tracheal route on day 0. A) Five days earlier, mice were injected i.p. with 200 μg of control or CpG ODN. B) Mice were treated with 0 - 200 μg of CpG ODN 5 days before BLM. C) Mice were treated with 200 μg of CpG ODN 5 days before, at the same time, or 5 days after BLM instillation. Data represent combined results from 2-3 independent experiments involving a total of 11-20 mice/group. Survival was analyzed with Kaplan-Meier statistics using the log rank test. *; p < 0.05, **; p < 0.005.