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Table 3 Characteristics of the pulmonary blood flow (PBF) waveform in fetuses before during (at selected time points) and after in uter o ventilation (IUV).

From: Pulmonary hemodynamic responses to in utero ventilation in very immature fetal sheep

 

RESPONDERS

NON RESPONDERS

 

PRE-IUV

20 min

2 hrs

11 hrs

POST IUV

PRE-IUV

20 min

2 hrs

11 hrs

POST-IUV

Peak systolic flow (mL/min)

179 ± 54a

234 ± 65b

173 ± 54a

174 ± 54a

159 ± 46a

203 ± 19xy

220 ± 14xy

187 ± 36x

181 ± 33xy

247 ± 1x

Post-systolic minimum flow (mL/min)

-65.9 ± 22

11.5 ± 14

-52.9 ± 12

-75.0 ± 19

-66.2 ± 20

-71.6 ± 11

-90.3 ± 14

-89.8 ± 24

-88.5 ± 21

-94.0 ± 16

End-diastolic flow (mL)

-22.6 ± 6.5a

11.5 ± 10.9b

-19.1 ± 5.0a

-28.1 ± 8.8a

-24.2 ± 7.4a

-33.2 ± 1.3

-38.8 ± 0.7

-35.3 ± 13.1

-34.1 ± 9.6

-29.9 ± 5.6

Mean diastolic flow (mL)

-10.9 ± 4.7a

49.0 ± 16.5b

-6.1 ± 2.7a

-15.3 ± 2.3a

-15.4 ± 4.7a

-26.8 ± 4.0

-22.4 ± 5.2

-21.2 ± 4.2

-15.7 ± 6.2

-17.7 ± 10.7

Pulsatility index

1.4 ± 0.0a

1.0 ± 0.0b

1.0 ± 0.1b

1.5 ± 0.0a

1.4 ± 0.0a

1.5 ± 0.0

1.4 ± 0.0

1.2 ± 0.2

1.5 ± 0.0

1.4 ± 0.1

Pulse amplitude (mL/min)

193 ± 54

162 ± 34

167 ± 47

170 ± 44

165 ± 48

227 ± 24

230 ± 15

216 ± 46

212 ± 35

242 ± 2

  1. Values that do not share a common letter are significantly different from each other (p< 0.05). Overall in all parameters measured, the responding fetuses were significantly different to the non-responding fetuses (p<0.001).