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  1. Research

    Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort

    An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes.

    Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F. M. Wouters, Claus Vogelmeier…

    Respiratory Research 2017 18:14

    Published on: 13 January 2017

  2. Research

    Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

    Exposure to elevated levels of particulate matter (PM) is associated with increased risk of morbidity and mortality due to respiratory tract viral infections in infants. Recent identification of environmentall...

    Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I. Lee, Bishwas Shrestha and Stephania A. Cormier

    Respiratory Research 2017 18:15

    Published on: 13 January 2017

  3. Research

    Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD—a randomised controlled study

    Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on l...

    Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J. Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens and Martin Brutsche

    Respiratory Research 2017 18:13

    Published on: 11 January 2017

  4. Research

    End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis

    Cystic fibrosis (CF) lung disease is characterised by vigorous airway inflammation eventually resulting in severe lung damage. This study aimed to describe the diversity of the inflammatory pattern in end-stag...

    Elise J. Lammertyn, Elly Vandermeulen, Hannelore Bellon, Stephanie Everaerts, Stijn E. Verleden, Kathleen Van Den Eynde, Ken R. Bracke, Guy G. Brusselle, Pieter C. Goeminne, Erik K. Verbeken, Bart M. Vanaudenaerde and Lieven J. Dupont

    Respiratory Research 2017 18:10

    Published on: 10 January 2017

  5. Research

    Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples

    Preinvasive squamous cell cancer (PSCC) are local transformations of bronchial epithelia that are frequently observed in current or former smokers. Their different grades and sizes suggest a continuum of dyspl...

    Andre Koper, Leo A. H. Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A. Lindsay and Richard Booton

    Respiratory Research 2017 18:12

    Published on: 10 January 2017

  6. Research

    A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

    Long-acting muscarinic antagonist/long-acting β2-agonist combinations are recommended for patients whose chronic obstructive pulmonary disease (COPD) is not managed with monotherapy. We assessed the efficacy and ...

    Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Respiratory Research 2017 18:8

    Published on: 6 January 2017

  7. Research

    Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination

    Cigarette smoke suppresses innate immunity, making smokers more susceptible to infection. The NLRP3 inflammasome is a multi-protein complex that releases interleukin (IL) -1β and IL -18. These cytokines are cr...

    SeungHye Han, Jacob A. Jerome, Alyssa D. Gregory and Rama K. Mallampalli

    Respiratory Research 2017 18:2

    Published on: 5 January 2017

  8. Research

    The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)

    ICAM-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable Haemophilus influenzae, two major pathogens in COPD. Increased cell-surface expression of ICAM-1 in response to tobacco smoke exposure h...

    Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal and Eugene Haydn Walters

    Respiratory Research 2017 18:6

    Published on: 5 January 2017

  9. Research

    Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment

    Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) m...

    Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian and Jiang-Bo Liu

    Respiratory Research 2017 18:7

    Published on: 5 January 2017

  10. Research

    Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease

    Chronic obstructive pulmonary disease (COPD) is a progressive, irreversible chronic inflammatory disorder typified by increased recruitment of monocytes, lymphocytes and neutrophils. Because of this, as well a...

    Xiaomin Dang, Xiaoyan Qu, Weijia Wang, Chongbing Liao, Ying Li, Xiaojin Zhang, Dan Xu, Carolyn J. Baglole, Dong Shang and Ying Chang

    Respiratory Research 2017 18:4

    Published on: 5 January 2017

  11. Research

    Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify nove...

    Jong-Uk Lee, Hyun Sub Cheong, Eun-Young Shim, Da-Jeong Bae, Hun Soo Chang, Soo-Taek Uh, Young Hoon Kim, Jong-Sook Park, Bora Lee, Hyoung Doo Shin and Choon-Sik Park

    Respiratory Research 2017 18:3

    Published on: 5 January 2017

  12. Research

    Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice

    Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Atrial natriuretic peptide (ANP), a heart-derived secretory peptide used clinically in Ja...

    Atsuko Okamoto, Takashi Nojiri, Kazuhisa Konishi, Takeshi Tokudome, Koichi Miura, Hiroshi Hosoda, Jun Hino, Mikiya Miyazato, Yohkoh Kyomoto, Kazuhisa Asai, Kazuto Hirata and Kenji Kangawa

    Respiratory Research 2017 18:1

    Published on: 3 January 2017

  13. Research

    Evidence for harm reduction in COPD smokers who switch to electronic cigarettes

    Electronic cigarettes (ECs) are battery-operated devices designed to vaporise nicotine, which may help smokers quitting or reducing their tobacco consumption. There is a lack of data on the health effects of E...

    Riccardo Polosa, Jaymin Bhagwanji Morjaria, Pasquale Caponnetto, Umberto Prosperini, Cristina Russo, Alfio Pennisi and Cosimo Marcello Bruno

    Respiratory Research 2016 17:166

    Published on: 16 December 2016

  14. Research

    Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

    Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be...

    Matthew J. Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S. Barnathan, Vedrana S. Susulic, Philip E. Silkoff, Peter J. Sterk and Frédéric Baribaud

    Respiratory Research 2016 17:165

    Published on: 15 December 2016

  15. Research

    The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

    Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown.

    Ling Zeng, Xue-tao Yang, Hai-sheng Li, Yong Li, Ce Yang, Wei Gu, Yin-han Zhou, Juan Du, Hai-yan Wang, Jian-hui Sun, Da-lin Wen and Jian-xin Jiang

    Respiratory Research 2016 17:164

    Published on: 7 December 2016

  16. Review

    The Microbiome and the Pathophysiology of Asthma

    Asthma is a chronic respiratory disease whose prevalence is increasing in the western world. Recently research has begun to focus on the role the microbiome plays in asthma pathogenesis in the hope of further ...

    Ashley Sullivan, Eoin Hunt, John MacSharry and Desmond M. Murphy

    Respiratory Research 2016 17:163

    Published on: 5 December 2016

  17. Research

    Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin

    Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenot...

    Olivier Burgy, Pierre-Simon Bellaye, Sebastien Causse, Guillaume Beltramo, Guillaume Wettstein, Pierre-Marie Boutanquoi, Françoise Goirand, Carmen Garrido and Philippe Bonniaud

    Respiratory Research 2016 17:162

    Published on: 29 November 2016

  18. Review

    Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ

    A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approac...

    Paula N. Nonaka, Juan J. Uriarte, Noelia Campillo, Vinicius R. Oliveira, Daniel Navajas and Ramon Farré

    Respiratory Research 2016 17:161

    Published on: 28 November 2016

  19. Research

    Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia

    Variable ventilation has been shown to improve pulmonary function and reduce lung damage in different models of acute respiratory distress syndrome. Nevertheless, variable ventilation has not been tested durin...

    Raquel F. de Magalhães, Cynthia S. Samary, Raquel S. Santos, Milena V. de Oliveira, Nazareth N. Rocha, Cintia L. Santos, Jamil Kitoko, Carlos A. M. Silva, Caroline L. Hildebrandt, Cassiano F. Goncalves-de-Albuquerque, Adriana R. Silva, Hugo C. Faria-Neto, Vanessa Martins, Vera L. Capelozzi, Robert Huhle, Marcelo M. Morales…

    Respiratory Research 2016 17:158

    Published on: 25 November 2016

  20. Research

    Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease

    The airway epithelium of chronic obstructive pulmonary disease (COPD) patients undergoes aberrant repair and remodeling after repetitive injury following exposure to environmental factors. Abnormal airway rege...

    Qixiao Liu, Haijun Li, Qin Wang, Yuke Zhang, Wei Wang, Shuang Dou and Wei Xiao

    Respiratory Research 2016 17:159

    Published on: 25 November 2016

  21. Research

    Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma

    Fluticasone furoate is a once-daily inhaled corticosteroid. This report provides an overview of safety and efficacy data that support the use of once-daily fluticasone furoate 100 μg or 200 μg in adult and ado...

    Paul M. O’Byrne, Loretta Jacques, Caroline Goldfrad, Namhee Kwon, Michael Perrio, Louisa J. Yates and William W. Busse

    Respiratory Research 2016 17:157

    Published on: 24 November 2016

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