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  1. Research

    Multiple biomarkers predict disease severity, progression and mortality in COPD

    Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severit...

    Rachel L. Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E. Miller, Ruth Tal-Singer and Russell P. Bowler

    Respiratory Research 2017 18:117

    Published on: 13 June 2017

  2. Letter to the Editor

    Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study

    The 1-min sit-to-stand (1-min STS) test and handgrip strength test have been proposed as simple tests of functional exercise performance in chronic obstructive pulmonary disease (COPD) patients. We assessed th...

    Sarah Crook, Anja Frei, Gerben ter Riet and Milo A. Puhan

    Respiratory Research 2017 18:112

    Published on: 2 June 2017

  3. Research

    VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells

    Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentia...

    Khadija Ourradi, Thomas Blythe, Caroline Jarrett, Shaney L. Barratt, Gavin I. Welsh and Ann B. Millar

    Respiratory Research 2017 18:116

    Published on: 2 June 2017

  4. Research

    Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy

    Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation of profibrotic myofibroblasts is a crucial proce...

    Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto…

    Respiratory Research 2017 18:114

    Published on: 2 June 2017

  5. Letter to the Editor

    Electronic applications for the CFQ-R scoring

    Patient reported outcomes (PROs) have become widely accepted outcome measures in cystic fibrosis (CF) and other respiratory diseases. The Cystic Fibrosis-Questionnaire-Revised (CFQ-R) is the best validated and...

    Andreas Ronit, Marco Gelpi, Jonathan Argentiero, Inger Mathiesen, Susanne D. Nielsen, Tanja Pressler and Alexandra L. Quittner

    Respiratory Research 2017 18:108

    Published on: 30 May 2017

  6. Research

    Which bronchodilator reversibility criteria can predict severe acute exacerbation in chronic obstructive pulmonary disease patients?

    It is unclear whether various bronchodilator reversibility (BDR) criteria affect the prognosis of chronic obstructive pulmonary disease (COPD). The aim of this study is to evaluate the impact of positive BDR d...

    Junghyun Kim, Woo Jin Kim, Chang-Hoon Lee, Sang Haak Lee, Myung-Goo Lee, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji-Hyun Lee, Seong Yong Lim, Ju Ock Na, Hun-Gyu Hwang, Yoonki Hong, Myoung Nam Lim, Chul-Gyu Yoo, Ki Suck Jung and Sang-Do Lee

    Respiratory Research 2017 18:107

    Published on: 30 May 2017

  7. Research

    Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori

    Helicobacter pylori (HP) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Azithromycin (AZ) is act...

    Seung Won Ra, Marc A. Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Shawn D. Aaron, Robert M. Reed, S. F. Paul Man…

    Respiratory Research 2017 18:109

    Published on: 30 May 2017

  8. Research

    Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling

    The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis of asthma. House dust mite (HDM), one of the most important allergens, could increase the airway epi...

    Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li and Shao-xi Cai

    Respiratory Research 2017 18:111

    Published on: 30 May 2017

  9. Research

    Evaluation of two strategies for the interpretation of tumour markers in pleural effusions

    Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help to identif...

    Jaume Trapé, Francesc Sant, Josefina Franquesa, Jesús Montesinos, Anna Arnau, Maria Sala, Oscar Bernadich, Esperanza Martín, Damià Perich, Concha Pérez, Joan Lopez, Sandra Ros, Enrique Esteve, Rafael Pérez, Jordi Aligué, Gabriel Gurt…

    Respiratory Research 2017 18:103

    Published on: 25 May 2017

  10. Research

    Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs

    In acute respiratory respiratory distress syndrome (ARDS) a sustained mismatch of alveolar ventilation and perfusion (VA/Q) impairs the pulmonary gas exchange. Measurement of endexpiratory lung volume (EELV) by m...

    Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David and Erik K. Hartmann

    Respiratory Research 2017 18:101

    Published on: 23 May 2017

  11. Research

    In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor

    Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The Sonic hedgehog (SHH) pathway is involved in vascular physiology. We sought to establish whether the SHH pathway has a...

    Priscilla Henno, Stanislas Grassin-Delyle, Emeline Belle, Marion Brollo, Emmanuel Naline, Edouard Sage, Philippe Devillier and Dominique Israël-Biet

    Respiratory Research 2017 18:102

    Published on: 23 May 2017

  12. Research

    Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients

    COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical manifestations of COPD and this classifica...

    Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers and Leo Koenderman

    Respiratory Research 2017 18:100

    Published on: 22 May 2017

  13. Research

    Reduced HDAC2 in skeletal muscle of COPD patients

    Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The...

    Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito and Peter J. Barnes

    Respiratory Research 2017 18:99

    Published on: 19 May 2017

  14. Research

    Genome-wide association study of subclinical interstitial lung disease in MESA

    We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis ...

    Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko…

    Respiratory Research 2017 18:97

    Published on: 18 May 2017

  15. Review

    Lung function imaging methods in Cystic Fibrosis pulmonary disease

    Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a cl...

    Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan and Bruce R. Thompson

    Respiratory Research 2017 18:96

    Published on: 17 May 2017

  16. Research

    Immunohistology and remodeling in fatal pediatric and adolescent asthma

    Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and ado...

    Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna and Mika J. Mäkelä

    Respiratory Research 2017 18:94

    Published on: 16 May 2017

  17. Research

    High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging

    The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world’s widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the i...

    Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall and David W. Parsons

    Respiratory Research 2017 18:95

    Published on: 16 May 2017

  18. Research

    Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation

    Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying ...

    Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan and Jeremy A. Hirota

    Respiratory Research 2017 18:92

    Published on: 15 May 2017

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